Abstract The BAG3 gene encodes the BAG3 protein, a multifunctional chaperone involved in proteostasis and protection of cardiomyocytes. Pathogenic BAG3 variants have previously been associated with dilated cardiomyopathy (DCM), including peripartum cardiomyopathy (PPCM). We present the case of a woman who complained of palpitations during the late postpartum period and was diagnosed with left ventricular dysfunction; genetic testing revealed a pathogenic variant of the BAG3 gene. Several cases of sudden death were noted in her family history. After 3 years of follow-up, ventricular function was significantly improved with regular cardiovascular medication, and no symptoms were reported. We emphasize the role of genetic testing in this case. BAG protein cardiomyocytes DCM, DCM , (DCM) PPCM. PPCM . (PPCM) dysfunction history followup, followup follow up, up follow-up medication reported (DCM (PPCM

The objective of this study was to analyze the prevalence of dietary and nutritional profiles of Brazilian adolescents and their associations with sociodemographic, behavioral and sustainability factors. Data from 16,556 adolescents evaluated by the 2015 National Adolescent Health Survey were used. The information was generated from Descriptive and Correspondence Analysis of the main variables - food and nutritional profiles (combination of dietary pattern categories with nutritional status categories) - and secondary. The most prevalent profile was identified as the type of dietary pattern (BP) with the lowest nutritional risk (NB) with normal weight, grouping 42.6% (95%CI: 41.3-43.7) of the adolescents, followed by the PA profiles of higher NB with normal weight (28.1%; 95%CI: 27.1-29.0), BP of lower NB with excess weight (17.5%; 95%CI: 16.7-18.3), BP of higher NB with excess weight (9.2%; 95%CI: 8.6-9.8), BP of lower NB with thinness (1.5%; 95%CI: 1.3-1.8) and BP of greater NB with thinness (1.1%; 95%CI: 0.9-1.4). These food and nutritional profiles coexist with different ways of life among Brazilian adolescents marked by sociodemographic, behavioral and sustainability aspects. The identification of these profiles and how they are distributed in the population allows for a better diagnosis of the realities of adolescents and the planning of more targeted and resolute feeding actions.

O objetivo desse trabalho foi analisar as prevalências dos perfis alimentares e nutricionais de adolescentes brasileiros e suas associações com fatores sociodemográficos, comportamentais e de sustentabilidade. Foram utilizados dados de 16.556 adolescentes avaliados pela Pesquisa Nacional de Saúde do Escolar 2015. As informações foram geradas a partir de Análise descritiva e de Correspondência das variáveis principais – perfis alimentares e nutricionais (combinação de categorias do padrão alimentar com categorias do estado nutricional) - e secundárias. Identificou-se como perfil mais prevalente o tipo padrão alimentar (PA) de menor risco nutricional (RN) com eutrofia agrupando 42,6% (IC95%: 41,3-43,7) dos adolescentes, esse foi seguido pelos perfis PA de maior RN com eutrofia (28,1%; IC95%: 27,1-29,0), PA de menor RN com excesso de peso (17,5%; IC95%:16,7-18,3), PA de maior RN com excesso de peso (9,2%; IC95%:8,6-9,8), PA de menor RN com magreza (1,5%; IC95%:1,3-1,8) e PA de maior RN com magreza (1,1%; IC95%: 0,9-1,4). Esses perfis alimentares e nutricionais coexistem com formas de vida diferentes entre os adolescentes brasileiros marcadas por aspectos sociodemográficos, comportamentais e de sustentabilidade. A identificação desses perfis e como se distribuem na população permite um melhor diagnósticos das realidades dos adolescentes e ao planejamento de ações de alimentação mais direcionadas e resolutivas.

OBJECTIVE: To correlate the perceptions related to dietary intake with the domains and subscales of health-related quality of life (HRQL) in women with breast neoplasms receiving chemotherapy. METHODS: In this prospective study, 55 women with breast cancer were followed up during chemotherapy at three different times (T0, T1, T2). Before chemotherapy, perceptions related to food consumption were evaluated. HRQL was analyzed with the EORTC QLQ-C30 and Br23 instruments 21 days after each investigated cycle. The differences (T2-T0) in the subscales and HRQL domains were correlated with the differences (T2-T0) in the appetite scores. Spearman’s correlation was used to verify a possible correlation between differences in functional and overall HRQL domains (T2-T0) and differences in appetite scores for certain foods and between the differences in some subscales of EORTC QLQ-C30 and Br23 (T2-T0) and differences in appetite scores for certain food groups (T2-T0). RESULTS: Correlations between pain and appetite for bitter taste and between an increased appetite for juices and pain intensification or fatigue were identified, and pain was correlated with an appetite for starchy foods. An appetite for vegetables, legumes and meat/eggs was correlated with physical function. The only significant correlation with social functions occurred between the appetite for sweet foods and these functions. We found a correlation between overall health, emotional function, social function and physical function and the appetite for juices. CONCLUSION: Chemotherapy alters the individual’s relationship with food and, consequently, the individual’s HRQL.

Resumo O objetivo deste estudo foi analisar o consumo alimentar e o estado nutricional de mulheres com câncer de mama (CM) em quimioterapia (QT). A avaliação dietética quantitativa foi realizada de acordo com as Dietary Reference Intakes (DRI) e a avaliação qualitativa pelo Índice de Qualidade da Dieta Revisado (IQD-R). Dentre o total de pacientes (n = 20), 60% (n = 12) apresentaram circunferência da cintura igual ou superior a 88 cm. Foi verificado 75% (n = 15) de indivíduos com excesso de peso. A média da ingestão de cálcio, cobre, ferro, fibra alimentar, magnésio, potássio, vitamina A, niacina, vitamina B6 e zinco encontrava-se abaixo da recomendação de ingestão adequada e o consumo de vitamina C, fósforo, manganês, sódio e tiamina encontrava-se acima. Quanto à análise do IQD-R, 80% (n = 16) das pacientes apresentaram uma “dieta que requer modificações”, enquanto que 20% (n = 4) apresentaram uma “dieta saudável”. Observou-se elevado excesso de peso, desequilíbrio na ingestão de micronutrientes e dieta que necessita melhorias. Dessa forma, a criação e a utilização de um protocolo de intervenção nutricional são de grande relevância para melhorar a dieta de pacientes com CM que realizam QT.

Abstract The objective behind this study was the analysis of food intake and the nutritional status of women with breast cancer (BC) undergoing chemotherapy (CT). The quantitative dietary evaluation was performed in accordance with Dietary Reference Intakes (DRI), whereas the qualitative evaluation was performed through the Brazilian Healthy Eating Index – Revised (BHEI-R).From among the total number of patients (n = 20), 60% (n = 12) presented waist circumference, equal to or higher than 88cm. It was noted that 75% (n = 15) individuals were overweight. The average intake for calcium, copper, iron, dietary fiber, magnesium, potassium, vitamin A, niacin, vitamin B6 and zinc, were found to be below adequate intake levels, while the intake of vitamin C, phosphorus, manganese, sodium and thiamine were all found to be above DRIs recommendations. As for the analysis of the BHEI-R, 80% (n = 16) of the patients presented a “diet that needs modifications”, while 20% (n = 4) presented a “healthy diet”. Noted from these observations was the presence of a high overweight rate, a discrepancy in the intake of micronutrients and a diet that needed improvements. In this manner, the establishment and use of a nutritional intervention protocol are very important when it comes to the improvement of the diet in patients with BC and who are undergoing CT.

Resumo O objetivo deste estudo foi analisar o consumo alimentar e o estado nutricional de mulheres com câncer de mama (CM) em quimioterapia (QT). A avaliação dietética quantitativa foi realizada de acordo com as Dietary Reference Intakes (DRI) e a avaliação qualitativa pelo Índice de Qualidade da Dieta Revisado (IQD-R). Dentre o total de pacientes (n = 20), 60% (n = 12) apresentaram circunferência da cintura igual ou superior a 88 cm. Foi verificado 75% (n = 15) de indivíduos com excesso de peso. A média da ingestão de cálcio, cobre, ferro, fibra alimentar, magnésio, potássio, vitamina A, niacina, vitamina B6 e zinco encontrava-se abaixo da recomendação de ingestão adequada e o consumo de vitamina C, fósforo, manganês, sódio e tiamina encontrava-se acima. Quanto à análise do IQD-R, 80% (n = 16) das pacientes apresentaram uma “dieta que requer modificações”, enquanto que 20% (n = 4) apresentaram uma “dieta saudável”. Observou-se elevado excesso de peso, desequilíbrio na ingestão de micronutrientes e dieta que necessita melhorias. Dessa forma, a criação e a utilização de um protocolo de intervenção nutricional são de grande relevância para melhorar a dieta de pacientes com CM que realizam QT.

Abstract The objective behind this study was the analysis of food intake and the nutritional status of women with breast cancer (BC) undergoing chemotherapy (CT). The quantitative dietary evaluation was performed in accordance with Dietary Reference Intakes (DRI), whereas the qualitative evaluation was performed through the Brazilian Healthy Eating Index – Revised (BHEI-R).From among the total number of patients (n = 20), 60% (n = 12) presented waist circumference, equal to or higher than 88cm. It was noted that 75% (n = 15) individuals were overweight. The average intake for calcium, copper, iron, dietary fiber, magnesium, potassium, vitamin A, niacin, vitamin B6 and zinc, were found to be below adequate intake levels, while the intake of vitamin C, phosphorus, manganese, sodium and thiamine were all found to be above DRIs recommendations. As for the analysis of the BHEI-R, 80% (n = 16) of the patients presented a “diet that needs modifications”, while 20% (n = 4) presented a “healthy diet”. Noted from these observations was the presence of a high overweight rate, a discrepancy in the intake of micronutrients and a diet that needed improvements. In this manner, the establishment and use of a nutritional intervention protocol are very important when it comes to the improvement of the diet in patients with BC and who are undergoing CT.