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Abstract Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters. diseases (TG lowdensity density LDL. LDL . (LDL) Highdensity High (HDL antiinflammatory anti inflammatory HDLc c performed risk mass addition LDLc nonHDLc, nonHDLc non c, non-HDL-c nonesterified esterified acids glucose nonHDLc/HDLc nonHDLcHDLc c/HDL ApoB/ApoAI. ApoBApoAI ApoB/ApoA I. ApoB ApoA I ApoB/ApoA-I Time Furthermore size parameters (LDL cHDL ApoAI ApoB/ApoAI ApoBApoA

https://doi.org/10.1590/s2175-97902022e20488

Tyramine exerts hypolipidemic and anti-obesity effects in vivo
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Morais, Thamires Maria Fontenele

; Melo, Tiago Sousa

; Dantas, Mariana Brito

; Ferreira, Jamile Magalhães

; Sousa, Daniel Freire de

; Magalhães, Emanuel Paula

; Menezes, Ramon Róseo Paula Pessoa Bezerra de

; Pessoa, Otília Deusdênia Loiola

; Feitosa, Mariana Lima

; Sousa, Francisca Cléa Florenço de

; Sampaio, Tiago Lima

; Queiroz, Maria Goretti Rodrigues de

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e201191

Abstract: En | Text: En | PDF: En

Abstract Obesity and dyslipidemia are conditions often associated with cardiovascular risk, inflammation, oxidative stress, and death. Thus, a new approach has been highlighted to promote research and development of pharmacological tools derived from natural sources. Among the most widely studied groups of substances, polyphenols such as tyramine stand out. This study investigated hypolipidemic and anti-obesity properties of tyramine. Oral toxicity evaluation, models of dyslipidemia and obesity were used. To induce dyslipidemia, Poloxamer-407 (P-407) was administered intraperitoneally. In the hypercholesterolemic and obesity model, specific diet and oral tyramine were provided. After 24h of P-407 administration, tyramine 2 mg/kg (T2) decreased triglycerides (TG) (2057.0 ± 158.5 mg/dL vs. 2838 ± 168.3 mg/dL). After 48h, TG were decreased by T2 (453.0 ± 35.47 vs. 760.2 ± 41.86 mg/dL) and 4 mg/kg (T4) (605.8 ± 26.61 760.2 ± 41.86 mg/dL). T2 reduced total cholesterol (TC) after 24h (309.0 ± 11.17 mg/dL vs. 399.7 ± 15.7 mg/dL); After 48h, 1 mg/kg (T1) (220.5 ± 12.78 mg/dL), T2 (205.8 ± 7.1 mg/dL) and T4 (216.8 ± 12.79 mg/dL), compared to P-407 (275.5 ± 12.1 mg/dL). The treatment decreased thiobarbituric acid reactive substances and nitrite in liver, increased superoxide dismutase, reduced the diet-induced dyslipidemia, decreasing TC around 15%. Tyramine reduced body mass, glucose, and TC after hypercaloric feed. Treatment with 5 mg/L (0.46 ± 0.04 ng/dL) and 10 mg/L (0.44 ± 0.02 ng/dL) reduced plasma insulin (1.18 ± 0.23 ng/dL). Tyramine increased adiponectin at 5 mg/L (1.02 ± 0.02 vs. 0.83 ± 0.02 ng/mL) and 10mg/L (0.96 ± 0.04 ng/mL). In conclusion, tyramine has low toxicity in rodents, has antioxidant effect, reduces plasma triglycerides and cholesterol levels. However, further studies should be conducted in rodents and non-rodents to better understand the pharmacodynamic and pharmacokinetic properties of tyramine.

https://doi.org/10.1590/s2175-97902022e201191

Atualização das Diretrizes Brasileiras de Valvopatias – 2020
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Tarasoutchi, Flavio

; Montera, Marcelo Westerlund

; Ramos, Auristela Isabel de Oliveira

; Sampaio, Roney Orismar

; Rosa, Vitor Emer Egypto

; Accorsi, Tarso Augusto Duenhas

; Santis, Antonio de

; Fernandes, João Ricardo Cordeiro

; Pires, Lucas José Tachotti

; Spina, Guilherme S.

; Vieira, Marcelo Luiz Campos

; Lavitola, Paulo de Lara

; Ávila, Walkiria Samuel

; Paixão, Milena Ribeiro

; Bignoto, Tiago

; Togna, Dorival Júlio Della

; Mesquita, Evandro Tinoco

; Esteves, William Antônio de Magalhães

; Atik, Fernando

; Colafranceschi, Alexandre Siciliano

; Moises, Valdir Ambrósio

; Kiyose, Alberto Takeshi

; Pomerantzeff, Pablo M. A.

; Lemos, Pedro A.

; Brito Junior, Fabio Sandoli de

; Weksler, Clara

; Brandão, Carlos Manuel de Almeida

; Poffo, Robinson

; Simões, Ricardo

; Rassi, Salvador

; Leães, Paulo Ernesto

; Mourilhe-Rocha, Ricardo

; Pena, José Luiz Barros

; Jatene, Fabio Biscegli

; Barbosa, Márcia de Melo

; Abizaid, Alexandre

; Ribeiro, Henrique Barbosa

; Bacal, Fernando

; Rochitte, Carlos Eduardo

; Fonseca, José Honório de Almeida Palma da

; Ghorayeb, Samira Kaissar Nasr

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Spina, Salvador Vicente

; Pignatelli, Ricardo H.

; Saraiva, José Francisco Kerr

Arquivos Brasileiros de Cardiologia

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oct 2020, Volume 115 N. 4 Pages 720 - 775

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201047 17824 downloads

Sistema de Informação de Vigilância da Qualidade da Água para Consumo Humano (Sisagua): características, evolução e aplicabilidade
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Oliveira Júnior, Aristeu de

; Magalhães, Tiago de Brito

; Mata, Renan Neves da

; Santos, Fabiana Sherine Ganem dos

; Oliveira, Daniel Cobucci de

; Carvalho, Jonas Lotufo Brant de

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2019, Volume 28 N. 1 elocation e2018117

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O Sistema de Informação de Vigilância da Qualidade da Água para Consumo Humano (Sisagua) é um instrumento utilizado no Brasil para registro das formas de abastecimento de água e dos dados de monitoramento da qualidade da água preconizados na norma de potabilidade. Essas informações são utilizadas no gerenciamento de riscos à saúde associados ao abastecimento de água no país e subsidiam a atuação da vigilância da qualidade da água para consumo humano, a estruturação de políticas públicas na área de saúde ambiental e saneamento, a prevenção de doenças de veiculação hídrica, e a caracterização da qualidade da água consumida pela população brasileira. Este artigo descreve o histórico do Sisagua e apresenta as principais características da atual versão (Sisagua 4) em relação à coleta e processamento dos dados, às variáveis, aos usos e acessos, à cobertura e qualidade dos dados, bem como focaliza as aplicabilidades, as limitações e os desafios do sistema.

Abstract The Drinking Water Quality Surveillance Information System (SISAGUA) is an instrument used in Brazil to record forms of water supply and water quality monitoring data recommended by the potable water standard. This information is used in the management of health risks associated with water supply in the country and supports the surveillance of drinking water quality, the structuring of public policies in the area of environmental health and sanitation, the prevention of waterborne diseases, and the characterization of the quality of water consumed by the Brazilian population. This article describes the history of SISAGUA and presents the main features of its current version (SISAGUA 4) regarding data collection and processing, variables, uses and accesses, data coverage and quality, as well as the system’s applicability, limitations and challenges.

Resumen El Sistema de Información de Vigilancia de la Calidad del Agua para Consumo Humano (Sisagua) es un instrumento utilizado en Brasil para registrar las formas de abastecimiento de agua y de los datos de monitoreo de la calidad del agua preconizados en la norma de potabilidad. Esta información se utiliza en la gestión de riesgos a la salud asociados al abastecimiento de agua en el país y da base a la actuación de la vigilancia de la calidad del agua para consumo humano, a la estructuración de políticas públicas en el área de salud ambiental y el saneamiento, a la prevención de enfermedades de transmisión hídrica, y a la caracterización de la calidad del agua consumida por la población brasileña. En este artículo se describe el histórico del Sisagua y se presentan las principales características de la actual versión (Sisagua 4) en relación a la recolección y el procesamiento de los datos, a las variables, a los usos y accesos, a la cobertura y calidad de los datos, así como a las aplicabilidad, limitaciones y los desafíos del sistema.

https://doi.org/10.5123/s1679-49742019000100024

Sistema de Informação de Vigilância da Qualidade da Água para Consumo Humano (Sisagua): características, evolução e aplicabilidade
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Oliveira Júnior, Aristeu de

; Magalhães, Tiago de Brito

; Mata, Renan Neves da

; Santos, Fabiana Sherine Ganem dos

; Oliveira, Daniel Cobucci de

; Carvalho, Jonas Lotufo Brant de

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2019, Volume 28 N. 1 elocation e2018117

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.5123/s1679-49742019000100024 6599 downloads

Atualização das Diretrizes Brasileiras de Valvopatias: Abordagem das Lesões Anatomicamente Importantes
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Tarasoutchi, Flavio

; Montera, Marcelo Westerlund

; Ramos, Auristela Isabel de Oliveira

; Sampaio, Roney Orismar

; Rosa, Vitor Emer Egypto

; Accorsi, Tarso Augusto Duenhas

; Lopes, Antonio Sergio de Santis Andrade

; Fernandes, João Ricardo Cordeiro

; Pires, Lucas José Tachotti

; Spina, Guilherme Sobreira

; Vieira, Marcelo Luiz Campos

; Lavitola, Paulo de Lara

; Bignoto, Tiago Costa

; Togna, Dorival Julio Della

; Mesquita, Evandro Tinoco

; Esteves, William Antonio de Magalhães

; Atik, Fernando Antibas

; Colafranceschi, Alexandre Siciliano

; Moisés, Valdir Ambrósio

; Kiyose, Alberto Takeshi

; Pomerantzeff, Pablo Maria Alberto

; Lemos Neto, Pedro Alves

; Brito Júnior, Fábio Sândoli de

; Weksler, Clara

; Brandão, Carlos Manuel de Almeida

; Poffo, Robinson

; Simões, Ricardo

; Rassi, Salvador

; Leães, Paulo Ernesto

; Rocha, Ricardo Mourilhe

; Pena, José Luiz Barros

; Jatene, Fabio Biscegli

; Barbosa, Márcia de Melo

; Souza Neto, João David de

; Saraiva, José Francisco Kerr

; Ghorayeb, Samira Kaissar Nasr

Arquivos Brasileiros de Cardiologia

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2017, Volume 109 N. 6 Pages 1 - 34

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.5935/abc.20180007 46086 downloads

Gestão das ações do setor saúde em situações de seca e estiagem
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Grigoletto, Jamyle Calencio

; Cabral, Adriana Rodrigues

; Bonfim, Camila Vicente

; Rohlfs, Daniela Buosi

; Silva, Eliane Lima e

; Queiroz, Fernanda Barbosa de

; Francischetti, Jaqueline

; Daniel, Mariely Helena Barbosa

; Resende, Rodrigo Matias de Sousa

; Andrade, Rosane Cristina de

; Magalhães, Tiago de Brito

Ciência & Saúde Coletiva

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mar 2016, Volume 21 N. 3 Pages 709 - 718

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A água é essencial para o desenvolvimento socioeconômico de um território e, também, para sobrevivência do ser humano. A escassez hídrica causa impactos diretos e indiretos sobre o ambiente, a economia e a saúde humana, podendo alterar o perfil de morbidade e mortalidade das doenças, além de impactar a oferta de serviços públicos essenciais à qualidade de vida. Este estudo visa contextualizar a ocorrência de estiagem e seca no Brasil, os efeitos à saúde humana, bem como ações a serem desenvolvidas pelo setor saúde para reduzir o risco de exposição da população das áreas atingidas, com ênfase nas ações de vigilância da qualidade da água para consumo humano. Trata-se de estudo descritivo, qualitativo, com base documental. Foram pesquisados documentos elaborados com base em iniciativas da Secretaria de Vigilância em Saúde do Ministério da Saúde até 2014. Considera-se necessário fortalecer a capacidade de atuação do Sistema Único de Saúde para o desenvolvimento de respostas oportunas para a redução do risco à saúde da população.

Abstract Water is essential for the socio-economic development of a region and also for the survival of human beings. Water scarcity has direct and indirect impacts on the environment, the economy and human health. It can change the profile of morbidity and mortality of diseases, as well as having an impact on the supply of services that are essential public to the quality of life. This study aims to contextualize the occurrence of drought in Brazil, its effects on human health, as well as actions to be developed by the health sector to reduce the risk to those living in affected areas, with an emphasis on the monitoring of the quality of drinking water. This is a descriptive, qualitative study with a documental basis. The documents that were researched were related to initiatives by the Health Surveillance Secretariat of the Ministry of Health up until 2014. It is necessary to strengthen the performance capacity of the Unified Health System (SUS) in order to develop timely responses to reduce the risk to public health.

https://doi.org/10.1590/1413-81232015213.26212015 5929 downloads

Gestão das ações do setor saúde em situações de seca e estiagem
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Grigoletto, Jamyle Calencio

; Cabral, Adriana Rodrigues

; Bonfim, Camila Vicente

; Rohlfs, Daniela Buosi

; Silva, Eliane Lima e

; Queiroz, Fernanda Barbosa de

; Francischetti, Jaqueline

; Daniel, Mariely Helena Barbosa

; Resende, Rodrigo Matias de Sousa

; Andrade, Rosane Cristina de

; Magalhães, Tiago de Brito

Ciência & Saúde Coletiva

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mar 2016, Volume 21 N. 3 Pages 709 - 718

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232015213.26212015 1025 downloads

Tratamento de esgotos sanitários em sistemas reatores UASB/wetlands construídas de fluxo horizontal: eficiência e estabilidade de remoção de matéria orgânica, sólidos, nutrientes e coliformes
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Calijuri, Maria Lúcia

; Bastos, Rafael Kopschitz Xavier

; Magalhães, Tiago de Brito

; Capelete, Bruna Cesca

; Dias, Edgard Henrique Oliveira

Engenharia Sanitaria e Ambiental

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sep 2009, Volume 14 N. 3 Pages 421 - 430

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Este trabalho apresentou os resultados de um estudo realizado durante 19 meses sobre o comportamento de wetlands construídas na remoção de matéria orgânica, sólidos, nutrientes e coliformes, em unidades em escala piloto de fluxo horizontal, subsuperficial e superficial, com tempo de detenção hidráulica entre 1,3 a 5,3 dias, operando como pós-tratamento de efluentes de reatores UASB (esgotos sanitários). A remoção de matéria orgânica e de sólidos mostrou-se elevada e estável, com eficiências médias de 70, 80 e 60% para SST, DBO5 e DQO, respectivamente. A remoção de nutrientes, após início promissor, mostrou-se instável e aparentemente influenciada pela temperatura. O sistema de tratamento revelou elevado potencial de remoção de coliformes, embora com variações relativamente amplas ao longo do período de operação: ≈ 2 log10 de remoção de coliformes totais e 2-4 log10 de remoção de Escherichia coli.

This work presented the results of a 19-month study on the performance of constructed wetlands in terms of organic matter, solids, nutrients and coliforms removal in pilot scale unities with horizontal, subsurface and surface flow, with hydraulic retention time from 1.3 to 5.3 days, as post-treatment of UASB effluents (domestic wastewater). Organic matter and solids were effectively and consistently removed, with average values of 70, 80 and 60% for TSS, BOD5 and COD, respectively. Nutrients removal, after a promising start up, became unstable and apparently influenced by temperature. The treatment system has also shown high potential to remove coliforms, although with relatively wide variations over the study period: ≈ 2 log10 reduction of total coliforms and 2-4 log10 reduction of Escherichia coli.

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