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ABSTRACT Objective: The aim of this study was to correlate the different curve patterns presented in idiopathic scoliosis with the sagittal cervical parameters of patients with this pathology. Method: This was a cross-sectional, descriptive and retrospective study. Information was collected from medical records and lateral panoramic radiographs of 49 patients with idiopathic scoliosis were analyzed. The data was assessed quantitatively using the following cervical parameters: Cobb from C2-C7, the distance from the center of gravity of the head to C7, the T1 slope, the thoracic Inlet angle, the cervical version, C7-S1 SVA, the Cobb angle of the main curve, and the kyphosis at T1-T12. These parameters were analyzed in relation to the different curve types presented and the lumbar and sagittal modifiers, as described by Lenke’s classification for idiopathic scoliosis. All the results were statistically analyzed and the significance level adopted was 5% (p<0.05). Results: The Cobb C2-C7 values showed a decrease in cervical lordosis in these patients (p = 0.048) and also showed an inverse relationship with thoracic kyphosis (p = 0.027). There was a statistically significant relationship between T1 inclination and loss of cervical lordosis (p = 0.003) also with variations in the sagittal modifier (p < 0.05). Lenke 2 and Lenke 4 curves were related to loss of cervical lordosis (p = 0.038). Conclusion: There was a loss of cervical lordosis in the patients in this study, evidenced by the alteration of the cervical sagittal parameters in these patients. The T1 slope was the variable that showed the greatest correlation with cervical alignment parameters, varying mainly in relation to the type of curve and sagittal modifier. In addition, curves affecting the upper thoracic spine (Lenke 2 and Lenke 4) significantly altered the sagittal cervical alignment of patients with idiopathic scoliosis, and it is recommended that they be carefully observed. Level of Evidence VI; Retrospective Observational Study. Objective pathology Method crosssectional, crosssectional cross sectional, sectional cross-sectional C2C7, C2C7 CC C2 C7 C T version C7S1 CS S1 S C7-S SVA T1T12. T1T12 TT T12. T12 T1-T12 modifiers Lenkes s 5 p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Results C2-C 0.048 0048 048 0.027. 0027 0.027 027 0.027) 0.003 0003 003 0.05. 005 0.05 0.05) 0.038. 0038 0.038 038 0.038) Conclusion addition observed VI Study C2C C7S T1T1 T1-T1 p00 p<0.0 (p<0.05 0.04 004 04 002 0.02 02 0.00 000 00 0.0 0.03 03 T1T T1-T p0 p<0. (p<0.0 0. p<0 (p<0. p< (p<0 (p<

Resumen: Objetivo: Correlacionar los diferentes patrones de curvatura presentados en la escoliosis idiopática con los parámetros sagitales cervicales de los pacientes con esta patología. Método: Se trata de un estudio transversal, descriptivo y retrospectivo. Se recogió información de las historias clínicas y se analizaron las radiografias panorâmicas laterales de 49 pacientes con escoliosis idiopática. Los datos se evaluaron cuantitativamente mediante los siguientes parámetros cervicales: Cobb de C2-C7, la distancia del centro de gravedad de la cabeza a C7, la inclinación de T1, el ángulo Inlet torácico, la versión cervical, C7-S1 SVA, el ángulo de Cobb de la curva principal y la cifosis en T1-T12. Estos parámetros se analizaron en relación con los diferentes tipos de curva presentados y los modificadores lumbares y sagitales, según la clasificación de Lenke para la escoliosis idiopática. Todos los resultados fueron analizados estadísticamente y el nivel de significación adoptado fue del 5% (p<0,05). Resultados: Los valores encontrados para Cobb C2-C7 mostraron una disminución de la lordosis cervical en estos pacientes (p = 0,048) y también mostraron una relación inversa con la cifosis torácica (p = 0,027). Existía una relación estadísticamente significativa entre la inclinación T1 y la pérdida de lordosis cervical (p = 0,003) y también con las variaciones del modificador sagital (p < 0,05). Las curvas de Lenke 2 y Lenke 4 estaban relacionadas con la pérdida de lordosis cervical (p = 0,038). Conclusión: Hubo una pérdida de lordosis cervical en los pacientes de este estudio, evidenciada por la alteración de los parámetros sagitales cervicales en estos pacientes. La inclinación T1 fue la variable que mostró mayor correlación con los parámetros de alineación cervical, variando principalmente en relación al tipo de curva y modificador sagital. Además, las curvas que afectan a la columna torácica superior (Lenke 2 y Lenke 4) alteraron significativamente el alineamiento cervical sagital de los pacientes con escoliosis idiopática, por lo que se recomienda una cuidadosa observación. Nivel de Evidencia IV; Estudio Observacional Retrospectivo. Resumen Objetivo patología Método transversal retrospectivo C2C7, C2C7 CC C2 C7 C T torácico C7S1 CS S1 S C7-S SVA T1T12. T1T12 TT T12. T12 T1-T12 5 p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Resultados C2-C 0,048 0048 048 0,027. 0027 0,027 027 0,027) 0,003 0003 003 0,05. 005 0,05 0,05) 0,038. 0038 0,038 038 0,038) Conclusión Además observación IV Retrospectivo C2C C7S T1T1 T1-T1 p00 p<0,0 (p<0,05 0,04 004 04 002 0,02 02 0,00 000 00 0,0 0,03 03 T1T T1-T p0 p<0, (p<0,0 0, p<0 (p<0, p< (p<0 (p<

Resumo: Objetivo: Correlacionar os diferentes padrões de curva apresentados na escoliose idiopática com os parâmetros sagitais cervicais de pacientes portadores dessa patologia. Método: Este foi um estudo transversal, descritivo e retrospectivo. Foram coletadas informações de prontuários e analisadas radiografias panorâmicas laterais de 49 pacientes portadores de escoliose idiopática. Os dados foram avaliados quantitativamente usando os seguintes parâmetros cervicais: Cobb de C2-C7, a distância do centro de gravidade da cabeça até C7, a inclinação T1, o ângulo do Inlet torácico, a versão cervical, C7-S1 SVA, o ângulo de Cobb da curva principal, e a cifose em T1-T12. Tais parâmetros foram analisados em relação aos diferentes tipos de curva apresentados e aos modificadores lombar e sagital, conforme descrito pela classificação de Lenke para escoliose idiopática. Todos os resultados foram analisados estatisticamente e o nível de significância adotado foi de 5% (p<0,05). Resultados: Os valores encontrados para o Cobb C2-C7 evidenciaram uma diminuição da lordose cervical nesses pacientes (p=0,048) e apresentaram, ainda uma relação inversa com a cifose torácica (p = 0,027). Houve relação estatisticamente relevante entre a inclinação de T1 e a perda da lordose cervical (p = 0,003) e também com as variações do modificador sagital (p < 0,05). Curvas Lenke 2 e Lenke 4 apresentaram relação com a perda da lordose cervical (p = 0,038). Conclusão: Houve uma perda da lordose cervical nos pacientes deste estudo, evidenciada pela alteração dos parâmetros sagitais cervicais nesses pacientes. A inclinação de T1 foi a variável que mais apresentou correlação com os parâmetros do alinhamento cervical, variando principalmente em relação ao tipo de curva e modificador sagital. Além disso, curvas que acometem a coluna torácica alta (Lenke 2 e Lenke 4) alteraram significativamente o alinhamento cervical sagital de pacientes portadores de escoliose idiopática, sendo recomendado observá-las cuidadosamente. Nível de Evidência IV; Estudo Observacional Retrospectivo. Resumo Objetivo patologia Método transversal retrospectivo C2C7, C2C7 CC C2 C7 C T torácico C7S1 CS S1 S C7-S SVA principal T1T12. T1T12 TT T12. T12 T1-T12 5 p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Resultados C2-C p=0,048 p0048 048 (p=0,048 0,027. 0027 0,027 027 0,027) 0,003 0003 003 0,05. 005 0,05 0,05) 0,038. 0038 0,038 038 0,038) Conclusão disso observálas observá las cuidadosamente IV Retrospectivo C2C C7S T1T1 T1-T1 p00 p<0,0 (p<0,05 p=0,04 p004 04 (p=0,04 002 0,02 02 0,00 000 00 0,0 0,03 03 T1T T1-T p0 p<0, (p<0,0 p=0,0 (p=0,0 0, p<0 (p<0, p=0, (p=0, p< (p<0 p=0 (p=0 (p< p= (p=

https://doi.org/10.1590/s1808-185120252401290619

Priming seeds with hydrogen peroxide attenuates damage caused by salt stress in sorghum
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Limão, Marcelo A. R.

; Barbosa, Joicy L.

; Medeiros, Aldair de S.

; Maia Júnior, Sebastião de O.

; Magalhães, Ivomberg D.

; Pimenta, Thiago A.

; Gonzaga, Giordano B. M.

; Sousa, Valéria F. de O.

; Siqueira, Glécio M.

; Marques, Jordânio I.

; Sousa, Washington da S.

; Leite, Patrício G.

Revista Brasileira de Engenharia Agrícola e Ambiental

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apr 2024, Volume 28 N. 4 elocation e279087

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A salinidade afeta processos fisiológicos, como a fotossíntese, em diversas culturas agrícolas, como o sorgo, em todo o mundo. Dessa forma, técnicas mitigadoras como o condicionamento de sementes com peróxido de hidrogênio (H2O2) podem aumentar a tolerância das plantas ao estresse salino. Assim, o objetivo do presente estudo foi avaliar o condicionamento de sementes de sorgo com peróxido de hidrogênio nas trocas gasosas e na fitomassa da planta sob estresse salino. Os tratamentos foram distribuídos em delineamento de blocos casualizados, em arranjo fatorial 4 × 4, com quatro níveis de condutividade elétrica da água de irrigação (CEa- 0,3, 1,5, 3,5 e 5,5 dS m-1) e quatro concentrações de H2O2 (0, 6, 12 e 18 μM L-1), com três repetições. A salinidade da água reduziu as trocas gasosas, a massa fresca e seca da parte aérea, além do teor de água nas plantas de sorgo. Entretanto, o condicionamento das sementes com H2O2 melhorou as trocas gasosas e o acúmulo de massa seca das plantas. O condicionamento de sementes com dose de H2O2 de 8,2 µM aumenta a aclimatação de plantas de sorgo sob estresse salino. fisiológicos fotossíntese agrícolas mundo forma HO H (H2O2 salino Assim casualizados CEa (CEa 03 0 3 0,3 15 1 5 1,5 35 3, 55 5, m1 m m-1 H2O 0, (0 6 L1, L1 L , L-1) repetições aérea Entretanto 82 8 2 8, (H2O 1, m- ( L-1 L-

ABSTRACT Salinity affects physiological processes, such as photosynthesis, in various agricultural crops, such as sorghum, around the world. Thus, mitigating techniques such as priming seeds with hydrogen peroxide (H2O2) can increase plant tolerance to salt stress. Thus, the objective of present study was to evaluate the priming of seeds with hydrogen peroxide on gas exchange and shoot phytomass of sorghum grown under salt stress. The treatments were distributed in a randomized block design, in a 4 × 4 factorial arrangement, with four levels of electrical conductivity of irrigation water - (ECw- 0.3, 1.5, 3.5, and 5.5 dS m-1) and four concentrations of H2O2 (0, 6, 12, and 18 μM L-1), with three replications. The salinity of the water reduced gas exchange, shoot fresh and dry mass, in addition to shoot moisture content in sorghum plants. However, priming the seeds with H2O2 improved gas exchange and the accumulation of plant dry mass. Seed priming with H2O2 at dose of 8.2 µM increases the acclimatization of sorghum plants under salt stress. processes photosynthesis crops world Thus HO H O (H2O2 stress design arrangement ECw (ECw 03 0 3 0.3 15 1 5 1.5 35 3.5 55 5. m1 m m-1 H2O 0, (0 6 12 L1, L1 L , L-1) replications mass However 82 8 2 8. (H2O 0. 1. 3. m- ( L-1 L-

https://doi.org/10.1590/1807-1929/agriambi.v28n4e279087

Prospective, randomized, controlled trial assessing the effects of a driving pressure–limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan Prospective randomized pressurelimiting pressure limiting communityacquired community acquired STAMINA trial)
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Maia, Israel Silva

; Medrado Jr, Fernando Azevedo

; Tramujas, Lucas

; Tomazini, Bruno Martins

; Oliveira, Júlia Souza

; Sady, Erica Regina Ribeiro

; Barbante, Letícia Galvão

; Nicola, Marina Lazzari

; Gurgel, Rodrigo Magalhães

; Damiani, Lucas Petri

; Negrelli, Karina Leal

; Miranda, Tamiris Abait

; Santucci, Eliana

; Valeis, Nanci

; Laranjeira, Ligia Nasi

; Westphal, Glauco Adrieno

; Fernandes, Ruthy Perotto

; Zandonai, Cássio Luis

; Pincelli, Mariangela Pimentel

; Figueiredo, Rodrigo Cruvinel

; Bustamante, Cíntia Loss Sartori

; Norbin, Luiz Fernando

; Boschi, Emerson

; Lessa, Rafael

; Romano, Marcelo Pereira

; Miura, Mieko Cláudia

; Alencar Filho, Meton Soares de

; Dantas, Vicente Cés de Souza

; Barreto, Priscilla Alves

; Hernandes, Mauro Esteves

; Grion, Cintia Magalhães Carvalho

; Laranjeira, Alexandre Sanches

; Mezzaroba, Ana Luiza

; Bahl, Marina

; Starke, Ana Carolina

; Biondi, Rodrigo Santos

; Dal-Pizzol, Felipe

; Caser, Eliana Bernadete

; Thompson, Marlus Muri

; Padial, Andrea Allegrini

; Veiga, Viviane Cordeiro

; Leite, Rodrigo Thot

; Araújo, Gustavo

; Guimarães, Mário

; Martins, Priscilla de Aquino

; Lacerda, Fábio Holanda

; Hoffmann Filho, Conrado Roberto

; Melro, Livia

; Pacheco, Eduardo

; Ospina-Táscon, Gustavo Adolfo

; Ferreira, Juliana Carvalho

; Freires, Fabricio Jocundo Calado

; Machado, Flávia Ribeiro

; Cavalcanti, Alexandre Biasi

; Zampieri, Fernando Godinho

Critical Care Science

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2024, Volume 36 elocation e20240210en

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

Occurrence of arbovirus infections in two riverine populations in the municipality of Humaitá, Amazonas, Brazil Humaitá Amazonas
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Silva, Jaqueline Carvalho de Oliveira

; Siqueira, Igor Rodrigo Ferreira

; Dornelas, Leormando Fortunato

; Ribeiro, Cristhian Magalhães

; Gomes, João Pedro Berno

; Guadagnin, Iagor Wingenbah

; Pereira, Antonieta Relvas

; Julião, Genimar Rebouças

; Camargo, Juliana de Souza Almeida Aranha

; Basano, Sergio Almeida

; Camargo, Luís Marcelo Aranha

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00403-2024

Abstract: En | Text: En | PDF: En

ABSTRACT Background: The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations. Methods: This cross-sectional study was conducted in a riverside population in the Humaitá municipality of the Brazilian Amazon. More than 80% of the local population participated in this study. Entomological samples were collected to identify local mosquito vectors. Results: Analysis of 205 human serological samples revealed IgG antibodies against the dengue virus in 85 individuals. No molecular positivity was observed in human samples. Entomological analyses revealed 3,187 Diptera species, with Mansonia being the most frequent genus. Aedes aegypti and Aedes albopictus were not detected in the two collections. Conclusions: IgG antibodies against the dengue virus were highly prevalent, suggesting previous exposure. The absence of the arbovirus vectors Aedes aegypti and Aedes albopictus in the samples supports the hypothesis that the infections recorded likely occurred outside the riverside communities investigated. Background lakes Brazil Zika chikungunya surveillance Ig G populations Methods crosssectional cross sectional 80 Results 20 8 individuals 3187 3 187 3,18 species genus collections Conclusions prevalent exposure investigated 2 318 18 3,1 31 1 3,

https://doi.org/10.1590/0037-8682-0515-2023

Different profiles of chemokines, cytokines and cell growth factors in plasma samples from patients with leprosy, leprosy reactions and households contacts chemokines
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de Carvalho, Jairo Campos

; Pascoal-Xavier, Marcelo Antônio

; Araújo, Marcelo Grossi

; Teixeira-Carvalho, Andrea

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Coelho-dos-Reis, Jordana Grazziela Alves

; Araújo, Márcio Sobreira Silva

Memórias do Instituto Oswaldo Cruz

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2024, Volume 119 elocation e230129

Abstract: En | Text: En | PDF: En

BACKGROUND Leprosy is a highly neglected disease that is considered a serious public health problem in many countries. This illness is characterised by a variety of clinical and histopathological manifestations that are related to the patient immune response. OBJECTIVES This work aimed evaluate the profile of circulating immune mediators in the plasma from patients classified clinically as paucibacillary (PB), multibacillary (MB), households contacts (HHC), type1 leprosy reaction (T1R), type2 leprosy reaction (T2R) and control individuals without medical history of leprosy (CTL). METHODS To assessment of the plasma immune mediators was used multiplex microbeads immunoassay “Luminex”. FINDINGS The results showed that patients (PB) had a regulatory-biased profile, while MB revealed a pro-inflammatory trend of highly expressed biomarkers. HHC display conspicuously increased levels in the plasma of the chemokines (CCL2, CCL3, CCL4, CCL5 and CXCL8), pro-inflammatory cytokines (IFN-γ,TNF and IL-1β), modulating cytokines (IL-9 and IL-1Ra) and growth factors (PDGF, G-CSF and IL-2). Interestingly, HHC displayed superior production of IFN-γ as compared to other leprosy groups, indicating a putative protective role for this cytokine during chronic Mycobacterium leprae exposure. MAIN CONCLUSION Further investigations are currently underway to elucidate the potential of these mediators as biomarkers applicable to the diagnosis/prognosis of leprosy and also T1R and T2R leprosy reactions. countries response PB, PB , MB, (MB) HHC, (HHC) type T1R, TR T R (T1R) (T2R CTL. CTL . (CTL) Luminex. Luminex “Luminex” (PB regulatorybiased regulatory biased proinflammatory pro inflammatory CCL2, CCL2 CCL (CCL2 CCL3 CCL4 CXCL8, CXCL8 CXCL CXCL8) IFNγ,TNF IFNγTNF IFN γ,TNF γ TNF IL1β, IL1β ILβ IL 1β β IL-1β) IL9 9 (IL- IL1Ra ILRa 1Ra Ra IL-1Ra PDGF, PDGF (PDGF GCSF G CSF IL2. IL2 2 IL-2) Interestingly IFNγ groups exposure diagnosisprognosis diagnosis prognosis reactions (MB (HHC (T1R (CTL “Luminex (CCL γTNF IL-1β (IL IL-2 IL-

https://doi.org/10.1590/0074-02760230129

O MERCADO DAS ESCOLINHAS DE FUTEBOL EM BELO HORIZONTE
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Dias, Cleber

; Magalhães, Marcelo de Freitas Pires

; Castilho, Cesar Teixeira

; Parolini, Pedro Lucas

; Lima, Marcelo Rochael de Melo

Movimento

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2024, Volume 30 elocation e30002

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este estudo analisa a quantidade e a distribuição territorial das escolinhas de futebol em Belo Horizonte. O objetivo é examinar quantos estabelecimentos desse tipo existem na cidade, onde estão localizados e quais critérios seus proprietários empregam para essa decisão. Para isso, utilizamos dados quantitativos e qualitativos, baseados, respectivamente, em informações sobre a localização desses estabelecimentos e dados censitários, de um lado, e entrevistas semiestruturadas realizadas com proprietários de escolinhas de futebol da cidade, de outro. Nossa interpretação geral é a de que escolinhas de futebol se distribuem aleatoriamente pela cidade em razão de circunstâncias que impõem uma lógica oportunista na tomada de decisão acerca da abertura de um estabelecimento comercial desse tipo. Horizonte isso qualitativos baseados respectivamente censitários lado outro

Abstract The study analyzes the quantity and geographical distribution of “football schools” in Belo Horizonte. The objective is to examine how many of these establishments exist in the city, where they are located and what criteria their owners use to make this decision. For this, we used quantitative and qualitative data, based on information about the location of these establishments and census data, on the one hand, and semi-structured interviews with owners of soccer schools in the city, on the other. Our general interpretation is that football schools are distributed randomly throughout the city due to circumstances impose an opportunistic logic on decision-making. Horizonte decision data hand semistructured semi structured other decisionmaking. decisionmaking making. making decision-making

Resumen Este estudio analiza la cantidad y la distribución territorial de las “escuelas de fútbol” en Belo Horizonte. El objetivo es examinar cuántos establecimientos de este tipo existen en la ciudad, dónde están ubicados y qué criterios utilizan sus propietarios para esta decisión. Para ello, se utilizaron datos cuantitativos y cualitativos, basados en información sobre la ubicación de estos establecimientos y datos censales, por un lado, y entrevistas semiestructuradas a propietarios de escuelas de fútbol de la ciudad, por otro. Nuestra interpretación general es que las escuelas de fútbol se distribuyen aleatoriamente por la ciudad debido a circunstancias que imponen una lógica de opotunismo en la toma de decisiones sobre la apertura de un establecimiento comercial de este tipo. Horizonte decisión ello cualitativos censales lado otro

https://doi.org/10.22456/1982-8918.131964

USE OF TRANEXAMIC ACID IN ADULTS SCOLIOSIS SURGERY: SYSTEMATIC REVIEW AND META-ANALYSIS SURGERY METAANALYSIS META ANALYSIS
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Monteiro Neto, Geraldo Magella Villa Nova

; Araki, Jonathan Kioy Duarte

; Grana, Rafael Magalhães

; Mistro Neto, Sylvio

; Rosa, André Frazão

; Lima, Mauricio Coelho

; Tebet, Marcos Antônio

; Pasqualini, Wagner

; Cavali, Paulo Tadeu Maia

; Risso Neto, Marcelo Italo

Coluna/Columna

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2024, Volume 23 N. 2 elocation e285095

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: Avaliar os efeitos anti-hemorrágicos da utilização do ácido tranexâmico (TXA) nas cirurgias de escoliose em adultos. Nesta metanálise, considerou-se como principal desfecho o sangramento, utilizando-se o modelo fixo de Mantel-Haenszel. Também se empregou o teste Q de Cochran que apresenta como hipótese nula a afirmação de que os estudos que compõem a metanálise são homogêneos. Após a aplicação dos critérios de exclusão, dos 8 artigos previamente selecionados, 7 foram incluídos nas análises estatísticas, somando 911 pacientes (amplitude entre 76 e 355 pacientes). As taxas de incidência de eficácia entre os pacientes tratados experimentalmente foram, em média geométrica, de 45%. Em relação a perda de sangue, foram observados valores médios de 1302 ± 490 no grupo controle versus 1108 ± 150 mL no grupo experimental. Fatores biológicos como sexo masculino e tipo de cirurgia não influenciaram no desfecho protetor do TXA quanto à redução do sangramento (p > 0,05). Já a idade superior a 65 se mostrou estatisticamente significativa (p = 0,04) pelo teste de x2. Este estudo metanalítico demonstrou que a idade acima de 65 anos é um fator que aumenta o sangramento nessas cirurgias tendo o TXA pouca ação na redução do sangramento nesse grupo. Nível de Evidência I; Estudos Clínicos Randomizados e Controlados de Nível 1 cujos resultados foram homogêneos. RESUMO antihemorrágicos anti hemorrágicos (TXA adultos considerouse considerou utilizandose utilizando MantelHaenszel. MantelHaenszel Mantel Haenszel. Haenszel Mantel-Haenszel homogêneos exclusão selecionados estatísticas 91 amplitude 35 pacientes. . pacientes) geométrica 45 45% sangue 130 49 110 15 experimental p 0,05. 005 0,05 0 05 0,05) 6 0,04 004 04 x2 x I 9 3 4 13 11 00 0,0 0,

ABSTRACT To evaluate the effects of using tranexamic acid in scoliosis surgeries in adults. This meta-analysis considered bleeding as the main outcome, using the Mantel-Haenszel fixed model. Cochran’s Q test was also used, whose null hypothesis is that the studies that make up the meta-analysis are homogeneous. After applying the exclusion criteria, seven of the eight papers previously selected were included in the statistical analyses, adding up to 911 patients (76 to 355 patients). The incidence rates of efficacy among experimentally treated patients were a geometric mean of 45%. Concerning blood loss, mean values were 1302 ± 490 in the control group versus 1108 ± 150 mL in the experimental group. Biological factors such as male gender and type of surgery did not influence the protective outcome of tranexamic acid in terms of reducing bleeding (p > 0.05). Age over 65 was statistically significant (p = 0.04) using the x2 test. This meta-analytical study showed that age over 65 is a factor that negatively influences the effects of tranexamic acid in reducing bleeding in scoliosis correction surgeries. Level of Evidence I; Randomized and Controlled Clinical Studies with homogeneous results. adults metaanalysis meta analysis MantelHaenszel Mantel Haenszel model Cochrans Cochran s used criteria analyses 91 76 (7 35 patients. . patients) 45 45% loss 130 49 110 15 p 0.05. 005 0.05 0 05 0.05) 6 0.04 004 04 x metaanalytical analytical I results 9 7 ( 3 4 13 11 1 00 0.0 0.

RESUMEN: Evaluar los efectos del uso de ácido tranexámico (TXA) en cirugías de escoliosis en adultos. Este metaanálisis consideró la hemorragia como resultado principal, utilizando el modelo fijo de Mantel-Haenszel. También se utilizó la prueba Q de Cochran, cuya hipótesis nula es que los estudios que componen el metaanálisis son homogéneos. Tras aplicar los criterios de exclusión, de los 8 artículos previamente seleccionados, 7 fueron incluidos en los análisis estadísticos, totalizando 911 pacientes (rango de 76 a 355 pacientes). Las tasas de incidencia de la eficacia entre los pacientes tratados experimentalmente fueron de una media geométrica del 45%. En cuanto a la pérdida de sangre, se observaron valores medios de 1302 ± 490 en el grupo de control frente a 1108 ± 150 mL en el grupo experimental. Factores biológicos como el sexo masculino y el tipo de cirugía no influyeron en el resultado protector del TXA en cuanto a la reducción de la hemorragia (p > 0,05). La edad superior a 65 años fue estadísticamente significativa (p = 0,04) mediante la prueba x2. Este estudio metaanalítico demostró que la edad superior a 65 años es un factor que influye negativamente en los efectos del TXA en la reducción de la hemorragia en las cirugías de corrección de la escoliosis. Nivel de Evidencia I; Estudios Clínicos Aleatorizados y Controlados de Nivel 1 cuyos resultados fueron homogéneos. RESUMEN (TXA adultos principal MantelHaenszel. MantelHaenszel Mantel Haenszel. Haenszel Mantel-Haenszel Cochran homogéneos exclusión seleccionados estadísticos 91 rango 35 pacientes. . pacientes) 45 45% sangre 130 49 110 15 experimental p 0,05. 005 0,05 0 05 0,05) 6 0,04 004 04 x2 x I 9 3 4 13 11 00 0,0 0,

https://doi.org/10.1590/s1808-185120242302285095

Evaluation of Brazilian women’s participation in the CNPQ in the field of medical research womens women s
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Keffer, Gabriele Martins

; Sousa, Árlen Almeida Duarte de

; Oliveira, Fabrício Emanuel

; Magalhães, Marcelo José da Silva

; Oliveira, Eduardo Araújo

; Martelli Júnior, Hercílio

Revista Brasileira de Educação Médica

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2024, Volume 48 N. 2 elocation e028

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A produção científica brasileira apresentou crescimento substancial e visibilidade internacional. Contudo, em geral, a participação das mulheres em atividades científicas ainda é limitada. Objetivo: Este estudo objetivou avaliar os indicadores de produtividade científica de mulheres bolsistas do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) na área de medicina. Método: Foi realizado estudo transversal com 541 (211 mulheres, 39%) pesquisadores cadastrados como bolsistas de produtividade em medicina do CNPq conforme lista disponibilizada em dezembro de 2022. Resultado: Houve predomínio de pesquisadores do sexo masculino (n = 330; 61%). Em ambos os grupos, masculino e feminino, a maioria dos investigadores encontra-se no nível 2, sendo 62,5% mulheres e 47,2% homens (p = 0,018). Todos os 211 pesquisadores foram distribuídos em 37 instituições diferentes e publicaram 34.969 artigos em revistas científicas, com média de 165,7 artigos por pesquisador. De 2018 a 2022, foram publicados 9.679 artigos. Ao longo de suas carreiras, os 211 pesquisadores orientaram 5.440 alunos de iniciação científica, 4.144 alunos de mestrado e 2.923 alunos de doutorado. Houve diferença significativa entre os níveis de bolsas quanto ao desenvolvimento de recursos humanos em iniciação científica (p = 0,040), mestrado (p = 0,027) e doutorado (p < 0,001). Conclusão: Ainda há menor participação de mulheres do que de homens entre os pesquisadores médicos do CNPq. Contudo, foi possível observar participação substancial das mulheres em todos os quesitos avaliados, incluindo a produção técnica e científica e a formação de recursos humanos. Introdução internacional Contudo geral limitada Objetivo (CNPq Método 54 (21 39% 39 2022 Resultado n 330 61%. 61 61% . 61%) grupos feminino encontrase encontra se 2 625 62 5 62,5 472 47 47,2 p 0,018. 0018 0,018 0 018 0,018) 21 3 34969 34 969 34.96 1657 165 7 165, pesquisador 201 9679 9 679 9.67 carreiras 5440 440 5.44 4144 4 144 4.14 2923 923 2.92 0,040, 0040 0,040 , 040 0,040) 0,027 0027 027 0,001. 0001 0,001 001 0,001) Conclusão avaliados (2 202 33 6 62, 47, 0,01 01 3496 96 34.9 16 20 967 67 9.6 544 44 5.4 414 14 4.1 292 92 2.9 004 0,04 04 0,02 002 02 000 0,00 00 ( 0,0 349 34. 1 9. 5. 41 4. 29 2. 0,

Abstract Introduction: Brazilian scientific production has shown substantial growth and achieved international visibility. However, in general, the participation of women in scientific activities remains limited. Objective: This study aimed to evaluate the indicators of scientific productivity of women fellows of the Council for Scientific and Technological Development (CNPq) in the field of Medicine. Method: This cross-sectional study was conducted on 541 (211 women, 39%) researchers registered as recipients of CNPq research productivity (PQ) scholarships in Medicine according to a list provided in December 2022. Results: There was a predominance of male researchers (n=330; 61%). In both the male and female groups, most researchers were at level 2, with 62.5% women and 47.2% men (p=0.018). All 211 female PQ scholars were distributed among 37 different institutions and published 34,969 papers in scientific journals, averaging 165.7 articles per researcher. In the last five years of the study period (from 2018 to 2022), 9,679 papers were published. Over their careers, the 211 researchers supervised 5,440 undergraduate research students, 4,144 master’s degree students, and 2,923 PhD candidates. There was a significant difference between the scholarship levels for the development of human resources in undergraduate research (p=0.040), master’s degree (p=0.027), and PhD. (p<0.001). Conclusion: There are still less women participating in CNPq medical research than men. However, we observed a substantial participation of women in all the assessed items, including technical and scientific production and the human resources training. Introduction visibility However general limited Objective (CNPq Method crosssectional cross sectional 54 (21 39% 39 (PQ 2022 Results n=330 n330 n 330 (n=330 61%. 61 61% . 61%) groups 2 625 62 5 62.5 472 47 47.2 p=0.018. p0018 p p=0.018 0 018 (p=0.018) 21 3 34969 34 969 34,96 journals 1657 165 7 165. researcher from 201 2022, , 2022) 9679 9 679 9,67 careers 5440 440 5,44 students 4144 4 144 4,14 masters master s 2923 923 2,92 candidates p=0.040, p0040 p=0.040 040 (p=0.040) p=0.027, p0027 p=0.027 027 (p=0.027) p<0.001. p0001 p<0.001 001 (p<0.001) Conclusion items training (2 202 n=33 n33 33 (n=33 6 62. 47. p001 p=0.01 01 (p=0.018 3496 96 34,9 16 20 967 67 9,6 544 44 5,4 414 14 4,1 292 92 2,9 p004 p=0.04 04 (p=0.040 p002 p=0.02 02 (p=0.027 p000 p<0.00 00 (p<0.001 ( n=3 n3 (n=3 p00 p=0.0 (p=0.01 349 34, 1 9, 5, 41 4, 29 (p=0.04 (p=0.02 p<0.0 (p<0.00 n= (n= p0 p=0. (p=0.0 p<0. (p<0.0 (n p=0 (p=0. p<0 (p<0. p= (p=0 p< (p<0 (p= (p< (p

https://doi.org/10.1590/1981-5271v48.2-2023-0271.ing

Anatomical, karyotypic, and nuclear DNA content studies in four morphotypes of wild lettuce Anatomical karyotypic
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Avelar, Ramon Ivo Soares

; Mendes, Marcelo Henrique Avelar

; Souza, Douglas Correa de

; Ferraz, Raiy Magalhães

; Resende, Kátia Ferreira Marques de

; Castro, Elisa de Melo

; Martins, Adalvan Daniel

; Gavilanes, Manuel Losada

; Bittencourt, Wanderley José Mantovani

; Resende, Luciane Vilela

Ciência e Agrotecnologia

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2024, Volume 48 elocation e008324

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A alface silvestre (Lactuca aff. canadensis L.), pertencente à família Asteraceae, ocorre de forma subespontânea no Brasil e pode ser originária da África, Ásia, Europa e América do Norte. Popularmente conhecida como alface canadense, é um vegetal folhoso não convencional. Os estudos sobre esta espécie são escassos no Brasil e seu nome científico é debatido entre especialistas. Possui alta variabilidade morfológica e classificação botânica controversa. Este estudo caracterizou os estômatos, organizou o cariótipo e determinou o conteúdo de DNA nuclear de quatro morfotipos de alface silvestre para facilitar a classificação correta. O material genético utilizado foi adquirido do germoplasma vegetal não convencional da UFLA. As folhas dos morfotipos de alface silvestre são hipoanfiestomáticas com maior número de estômatos na epiderme abaxial. Houve semelhanças entre os morfotipos (verde e roxo) e entre os tipos roxos lisos (folha estreita e folha larga) quanto ao número e tamanho dos estômatos. Nenhuma variação foi encontrada no número de cromossomos (2n = 18) ou no conteúdo de DNA entre os quatro morfotipos. A separação dos morfotipos de alface silvestre não correspondeu à classificação morfológica nem aos dados cariológicos. Os quatro morfotipos avaliados foram colocados sob a mesma espécie, e os resultados obtidos quando comparados com outros estudos nos levaram a inferir que os quatro morfotipos de Lactuca selvagem pertenciam à espécie L. indica e não a L. canadensis como se supunha anteriormente. Investigações adicionais podem fornecer conhecimento sobre a história evolutiva desta espécie. aff L., L , L.) Asteraceae África Ásia Norte canadense especialistas controversa correta UFLA abaxial verde roxo larga 2n n 18 cariológicos anteriormente 1

ABSTRACT Wild lettuce (Lactuca aff. canadensis L.), belonging to the Asteraceae family, occurs subspontaneously in Brazil and may originate from Africa, Asia, Europe and North America. Popularly known as Canada lettuce, it is an unconventional leafy vegetable. Studies on this species are scarce in Brazil, and its scientific name is debated among experts. It has high morphological variability and controversial botanical classification. This study characterized the stomata, organized the karyotype, and determined the nuclear DNA content of four morphotypes of wild lettuce to facilitate correct classification. The genetic material used was acquired from the non-conventional vegetable germplasm in UFLA. The leaves of wild lettuce morphotypes are hypoamphiestomatic with a greater number of stomata in the abaxial epidermis. There were similarities between the morphotypes (green and purple) and between the smooth purple types (narrow leaf and broad leaf) for the number and size of stomata. No variation was found in the number of chromosomes (2n = 18) or DNA content among the four morphotypes. The separation of the morphotypes of wild lettuce did not match the morphological classification or the karyological data. The four morphotypes evaluated were placed under the same species, and the results obtained when compared to other studies led us to infer that the four morphotypes of wild Lactuca belonged to the species L. indica and not L. canadensis as previously assumed. Further investigation may provide insights into the evolutionary history of this species. aff L., L , L.) family Africa Asia America experts karyotype nonconventional non conventional UFLA epidermis green narrow 2n n 18 data assumed 1

https://doi.org/10.1590/1413-7054202448008324

10.

The Hunga Tonga–Hunga Haʻapai volcanic barometric pressure pulse and meteotsunami travel recorded in several Antarctic stations TongaHunga Tonga
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EVANGELISTA, HEITOR

; GRIGIONI, PAOLO

; PEZZI, LUCIANO

; DOURADO, FRANCISCO

; HEIL, PETRA

; VILLELA, FRANCO N.J.

; PASSOS, HEBER R.

; NOGUEIRA, JULIANA

; MAGALHÃES, NEWTON

; SANTINI, MARCELO

; SCHMITHÜSEN, HOLGER

; JAÑA, RICARDO

; NORTON, TAYLOR

; AMARAL, CESAR

Anais da Academia Brasileira de Ciências

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2024, Volume 96 Suppl. 2 elocation e20240556

Abstract: En | Text: En | PDF: En

Abstract The Hunga Tonga–Hunga/Hunga-Haʻapai eruption on January 15, 2022 sent off a plume of ash material up to the stratosphere and triggered a meteotsunami and barometric pressure pulse that rippled through the atmosphere and oceans all around the world. The nature of the volcanic event and its global impacts on the oceans, atmosphere, lithosphere and the cryosphere are a matter of debate. Here we present a first overview of the time travel of the sound atmospheric pressure wave through the Antarctic continent based on in situ measurements, which represented a unique event observed through the polar ice sheet during the instrumental meteorological era. In addition, we estimated the tsunami travel time of the Hunga-Tonga event from a first order model to infer its impact over the Antarctic Sea ice and ice shelves. One outcome from our observations and modeling is the detection of the meteotsunami in the Antarctic Peninsula and the impact of the continental relief over the atmospheric pressure wave dispersion. Tonga–Hunga/HungaHaʻapai TongaHungaHungaHaʻapai Tonga–Hunga/Hunga Haʻapai Tonga 15 202 world debate measurements era addition HungaTonga shelves dispersion HungaHaʻapai TongaHungaHunga 1 20 2

https://doi.org/10.1590/0001-3765202420240556

11.

Sterilization of free-ranging female capybaras (Hydrochoerus hydrochaeris): a comparison between two surgical techniques freeranging free ranging Hydrochoerus hydrochaeris hydrochaeris)
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Jorge, Fabiana Morse Gosson

; Passos-Nunes, Fernanda Battistella

; Jorge-Neto, Pedro Nacib

; Donoso, Flavia Maria Pia Montenegro

; Nunes, Mariana Passos

; Steiner, Alexia Gazzola

; Labruna, Marcelo Bahia

; Roman, Ana Clara Kohara

; Cristofoli, Marilú

; Alcobaça, Mayla Magalhães de Oliveira

; Pizzutto, Cristiane Schilbach

; Assis Neto, Antonio Chaves de

Animal Reproduction

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2024, Volume 21 N. 4 elocation e20240053

Abstract: En | Text: En | PDF: En

Abstract This study evaluated two surgical sterilization techniques in free-ranging female capybaras (n = 21). The first group underwent uterine horn ligature (HL; n = 11), while the second was subjected to partial salpingectomy (S; n = 10). We assessed total operative time, incision length, the ease of identifying reproductive structures, the adequacy of exposure for surgical performance through flank or midline approaches, and the extent of abdominal viscera manipulation for each method. The HL method emerged as faster, with an average operative time difference of 16 minutes. In the S group, a flank mini-laparotomy over the ovarian topography facilitated easy exposure of the ipsilateral ovary and uterine tube, enabling ligature and partial resection of the uterine tube but not the uterine horn exposure. However, accessing the contralateral uterine tube without a bilateral incision was impractical, thus prolonging the total operative time due to the need for patient repositioning and new antisepsis procedures. Conversely, a post-umbilical approach for the HL method necessitated only one mini-laparotomy incision, offering ample uterine exposure for hysterotomy in pregnant females. Both methods involved minimal abdominal viscera manipulation and resulted in no fatalities or postoperative complications. Although direct comparison is limited by the distinct sterilization techniques and surgical approaches, this study underscores the challenges and surgical access of each method. Our findings endorse the HL technique as an effective contraception method for female capybaras to prevent the birth of seronegative offspring that could amplify Rickettsia sp., the causative agent of Brazilian spotted fever. freeranging free ranging 21. 21 . 21) (HL 11, 11 , 11) (S 10. 10 10) length structures approaches faster 1 minutes minilaparotomy mini laparotomy However impractical procedures Conversely postumbilical post umbilical females complications sp sp. fever 2

https://doi.org/10.1590/1984-3143-ar2024-0053

12.

Diretriz de Tomografia Computadorizada e Ressonância Magnética Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia – 2024 202 20 2
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Magalhães, Tiago Augusto

; Carneiro, Adriano Camargo de Castro

; Moreira, Valéria de Melo

; Trad, Henrique Simão

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Nacif, Marcelo Souto

; Schvartzman, Paulo R.

; Chagas, Antônio Carlos Palandrini

; Costa, Isabela Bispo Santos da Silva

; Schmidt, André

; Shiozaki, Afonso Akio

; Montenegro, Sérgio Tavares

; Piegas, Leopoldo Soares

; Zapparoli, Marcelo

; Nicolau, José Carlos

; Fernandes, Fabio

; Hadlich, Marcelo Souza

; Ghorayeb, Nabil

; Mesquita, Evandro Tinoco

; Gonçalves, Luiz Flávio Galvão

; Ramires, Felix José Alvarez

; Fernandes, Juliano de Lara

; Schwartzmann, Pedro Vellosa

; Rassi, Salvador

; Torreão, Jorge Andion

; Mateos, José Carlos Pachón

; Beck-da-Silva, Luiz

; Silva, Marly Conceição

; Liberato, Gabriela

; Oliveira, Gláucia Maria Moraes de

; Feitosa Filho, Gilson Soares

; Carvalho, Hilka dos Santos Moraes de

; Markman Filho, Brivaldo

; Rocha, Ricardo Paulo de Sousa

; Azevedo Filho, Clerio Francisco de

; Taratsoutchi, Flávio

; Coelho-Filho, Otavio Rizzi

; Kalil Filho, Roberto

; Hajjar, Ludhmila Abrahão

; Ishikawa, Walther Yoshiharu

; Melo, Cíntia Acosta

; Jatene, Ieda Biscegli

; Albuquerque, Andrei Skromov de

; Rimkus, Carolina de Medeiros

; Silva, Paulo Savoia Dias da

; Vieira, Thiago Dieb Ristum

; Jatene, Fabio Biscegli

; Azevedo, Guilherme Sant Anna Antunes de

; Santos, Raul D.

; Monte, Guilherme Urpia

; Ramires, José Antonio Franchini

; Bittencourt, Marcio Sommer

; Avezum, Alvaro

; Silva, Leonardo Sara da

; Abizaid, Alexandre

; Gottlieb, Ilan

; Precoma, Dalton Bertolim

; Szarf, Gilberto

; Sousa, Antônio Carlos Sobral

; Pinto, Ibraim Masciarelli Francisco

; Medeiros, Fábio de Morais

; Caramelli, Bruno

; Parga Filho, José Rodrigues

; Santos, Tiago Senra Garcia dos

; Prazeres, Carlos Eduardo Elias dos

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Avila, Luiz Francisco Rodrigues de

; Scanavacca, Mauricio Ibrahim

; Gowdak, Luis Henrique Wolff

; Barberato, Silvio Henrique

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 9 elocation e20240608

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240608

13.

Evaluation of d-dimer as outcome biomarker in COVID-19 acute respiratory distress patients ddimer d dimer COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Diniz, Simone Magalhães

; Mauad, Vitor Augusto Queiroz

; Fernandes, Caio Cesar Ferreira

; Bacci, Marcelo Rodrigues

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e57

Abstract: En | Text: En | PDF: En

ABSTRACT Acute respiratory distress syndrome is a significant complication in critical care patients. COVID-19 (C19)-associated severe respiratory failure is related to it, and d-dimer rise predicts a worse outcome. To investigate the association between d-dimer and the severity of this respiratory syndrome, we conducted a study in C19 intubated patients. A retrospective, single-center observational study was conducted with 64 C19 adult intubated patients. Strata of d-dimer results between patients was evaluated using survival analysis. Survival was higher in mild respiratory distress patients. D-dimer showed poor sensitivity and specificity in predicting respiratory failure severity. Risk assessment for death showed a higher prevalence of admission d-dimer results (HR 1.335; 95% CI 0.695–2.564). Our sample confidently represented the medical profile of C19 severe patients. Sepsis development in C19 is associated with the inflammatory storm in respiratory distress syndrome. As the receiver operating curves show, the increase in d-dimer results is consistent with inflammation rather than a prognostic biomarker. As expected, severe respiratory distress patients presented higher mortality. In summary, d-dimer results are not associated with the prognosis of C19 respiratory distress syndrome patients. COVID19 COVID 19 COVID-1 C19associated Cassociated C it ddimer d dimer outcome C1 retrospective singlecenter single center 6 analysis Ddimer D HR 1.335 1335 1 335 95 0.695–2.564. 06952564 0.695–2.564 . 0 695 2 564 0.695–2.564) show biomarker expected mortality summary COVID1 COVID- 1.33 133 33 9 0695256 0.695–2.56 69 56 1.3 13 3 069525 0.695–2.5 5 1. 06952 0.695–2. 0695 0.695–2 069 0.695– 06 0.695 0.69 0.6 0.

https://doi.org/10.1590/s1678-9946202466057

14.

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila

; Rêgo, Jozelia

; Machado, Ketty Lysie Libardi Lira

; Miyamoto, Samira Tatiyama

; Burian, Ana Paula Neves

; Dias, Laiza Hombre

; Pretti, Flavia Zon

; Batista, Danielle Cristina Filgueira Alves

; Mill, José Geraldo

; Oliveira, Yasmin Gurtler Pinheiro de

; Gadelha, Carolina Strauss Estevez

; Gouveia, Maria da Penha Gomes

; Moulin, Anna Carolina Simões

; Souza, Bárbara Oliveira

; Aguiar, Laura Gonçalves Rodrigues

; Vieira, Gabriel Smith Sobral

; Grillo, Luiza Lorenzoni

; Lima, Marina Deorce de

; Pasti, Laís Pizzol

; Surlo, Heitor Filipe

; Faé, Filipe

; Moulaz, Isac Ribeiro

; Macabú, Mariana de Oliveira

; Ribeiro, Priscila Dias Cardoso

; Magalhães, Vanessa de Oliveira

; Aguiar, Mariana Freitas de

; Biegelmeyer, Erika

; Peixoto;, Flávia Maria Matos Melo Campos

; Kayser, Cristiane

; Souza, Alexandre Wagner Silva de

; Castro, Charlles Heldan de Moura

; Ribeiro, Sandra Lúcia Euzébio

; Telles, Camila Maria Paiva França

; Bühring, Juliana

; Lima, Raquel Lima de

; Santos, Sérgio Henrique Oliveira Dos

; Dias, Samuel Elias Basualto

; Melo, Natália Seixas de

; Sanches, Rosely Holanda da Silva

; Boechat, Antonio Luiz

; Sartori, Natália Sarzi

; Hax, Vanessa

; Dória, Lucas Denardi

; Rezende, Rodrigo Poubel Vieira de

; Baptista, Katia Lino

; Fortes, Natália Rodrigues Querido

; Melo, Ana Karla Guedes de

; Melo, Tâmara Santos

; Vieira, Rejane Maria Rodrigues de Abreu

; Vieira, Adah Sophia Rodrigues

; Kakehasi, Adriana Maria

; Tavares, Anna Carolina Faria Moreira Gomes

; Landa, Aline Teixeira de

; Costa, Pollyana Vitoria Thomaz da

; Azevedo, Valderilio Feijó

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Pinheiro, Marcelo de Medeiros

; Monticielo, Odirlei André

; Reis-neto, Edgard Torres Dos

; Ferreira, Gilda Aparecida

; Souza, Viviane Angelina de

; Teixeira-Carvalho, Andréa

; Xavier, Ricardo Machado

; Sato, Emilia Inoue

; Valim, Valeria

; Pileggi, Gecilmara Salviato

; Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

15.

Tuberculin skin test repetition after TNF-α inhibitors in patients with chronic inflammatory arthritis: a long-term retrospective cohort in endemic area TNFα TNF α arthritis longterm long term
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Magalhães, Vanessa de Oliveira

; Bonfiglioli, Karina Rossi

; Gomes, Carina More Frade

; Bonfá, Eloisa

; Medeiros-Ribeiro, Ana Cristina de

; Saad, Carla Gonçalves S.

; Pinheiro, Marcelo de Medeiros

Advances in Rheumatology

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2024, Volume 64 elocation 70

Abstract: En | Text: En | PDF: En

Abstract Objectives To evaluate the tuberculin skin test (TST) conversion in chronic inflammatory arthropathies (CIA) patients on TNFα inhibitors (TNFi) and without previous latent tuberculosis infection (LTBI) treatment. Methods Patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) with negative LTBI were retrospectively evaluated for TST conversion and active tuberculosis (TB) after six months of exposition to TNFi. Two groups were compared: patients who repeated TST (TST-repetition) during the follow-up and patients who did not (non-TST-repetition). Results A total of 355 CIA patients on TNFi were screened and 138 (38.9%) did not fulfill the inclusion criteria. Of the remaining 217 CIA patients, 81 (37.3%) repeated TST during TNFi treatment. TST conversion rate was observed in 18 (22.2%) patients without significant differences among CIA (p = 0.578). The number of TB cases was low (n = 10; 4.6%) and was similar in TST-repetition and non-TST-repetition groups [2 (2.5%) vs. 8 (5.9%), p = 0.328]. Of note, 30% of active TB occurred early (6–12 months of TNFi exposure) and the median (full range) time to incident TB was 1.3 (0.6–10.6) years, whereas the median (full range) time to TST repetition was later [3.3 (0.5–13.4) years]. The incidence of active TB was lower among RA patients than AS patients [342 (95% CI 41 − 1446) vs. 1.454 (95% CI 594-2993)/100,000 patient-years, p = 0.049]. Conclusion These results indicate that TST repetition is associated with a high conversion rate, suggesting the need for recommended treatment. The delayed repetition of TST and low number of active TB cases hampered the evaluation of this strategy effectiveness to prevent active infection. Larger studies with systematic repetition patterns are necessary. In addition, the study highlights the need for a greater surveillance for TB in AS patients. Key messages TST repetition is associated with a high conversion rate for positive LTBI after long-term TNFi. Active tuberculosis diagnosis occurs early (1.3 years) during TNFi therapy. AS patients require greater surveillance for incident TB. (TST (CIA (TNFi (LTBI treatment RA, , (RA) (AS PsA (PsA (TB compared TSTrepetition (TST-repetition followup follow up nonTSTrepetition. nonTSTrepetition non . (non-TST-repetition) 35 13 38.9% 389 38 9 (38.9% criteria 21 37.3% 373 37 3 (37.3% 1 22.2% 222 22 2 (22.2% 0.578. 0578 0.578 0 578 0.578) n 10 4.6% 46 4 6 [ 2.5% 25 5 (2.5% vs 5.9%, 59 5.9% (5.9%) 0.328. 0328 0.328 328 0.328] note 30 6–12 612 12 (6–1 exposure full range 1. 0.6–10.6 06106 (0.6–10.6 years 3.3 33 [3. 0.5–13.4 05134 (0.5–13.4 years. years] 342 [34 95% 95 (95 1446 1454 454 1.45 5942993/100,000 5942993100000 594 2993 /100,000 100 000 594-2993)/100,00 patientyears, patientyears patient patient-years 0.049. 0049 0.049 049 0.049] necessary addition longterm long term (1. therapy (RA (non-TST-repetition 38.9 (38.9 37.3 (37.3 22.2 (22.2 057 0.57 57 4.6 2.5 (2.5 5.9 (5.9% 032 0.32 32 6–1 61 (6– 0.6–10. 0610 (0.6–10. 3. [3 0.5–13. 0513 (0.5–13. 34 (9 144 145 45 1.4 5942993 5942993/100,00 594299310000 299 100000 /100,00 00 594-2993)/100,0 004 0.04 04 (1 38. (38. 37. (37. 22. (22. 05 0.5 4. 2. (2. 5. (5.9 03 0.3 6– (6 0.6–10 061 (0.6–10 0.5–13 051 (0.5–13 ( 14 594299 5942993/100,0 59429931000 29 10000 /100,0 594-2993)/100, 0.0 (38 (37 (22 0. (2 (5. 0.6–1 06 (0.6–1 0.5–1 (0.5–1 59429 5942993/100, 5942993100 1000 /100, 594-2993)/100 (3 (5 0.6– (0.6– 0.5– (0.5– 5942 5942993/100 594299310 /100 594-2993)/10 0.6 (0.6 (0.5 5942993/10 59429931 /10 594-2993)/1 (0. 5942993/1 /1 594-2993)/ (0 5942993/ / 594-2993) 594-2993 594-299 594-29 594-2 594-

https://doi.org/10.1186/s42358-024-00406-7

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