Search | SciELO

Abstract The recommendations in which the Mexican Society of Cardiology (SMC) in conjunction with the National Association of Cardiologists of Mexico (ANCAM) as well as different Mexican medical associations linked to cardiology are presented, after a comprehensive and consensual review and analysis of the topics related to cardiovascular diseases in the COVID-19 pandemic. Scientific positions are analyzed and responsible recommendations on general measures are given to patients, with personal care, healthy eating, regular physical activity, actions in case of cardio-respiratory arrest, protection of the patient and health personnel as well as precise indications in the use of non-invasive cardiovascular imaging, prescription of medications, care in specific topics such as systemic arterial hypertension, heart failure, arrhythmias and acute coronary syndromes, in addition to emphasizing electrophysiology, interventionism, cardiac surgery and in cardiac rehabilitation. The main interest is to provide the medical community with a general orientation on what to do in daily practice and patients with cardiovascular diseases in the setting of this unprecedented epidemiological crisis of COVID-19.

Resumen Se presentan las recomendaciones en las cuales la Sociedad Mexicana de Cardiología (SMC) en conjunto con la Asociación Nacional de Cardiólogos de México (ANCAM), así como diferentes asociaciones médicas mexicanas vinculadas con la cardiología, después de una revisión y análisis exhaustivo y consensuado sobre los tópicos relacionados con las enfermedades cardiovasculares en la pandemia de COVID-19, se analizan posturas científicas y se dan recomendaciones responsables sobre medidas generales a los pacientes, con cuidados personales, alimentación saludable, actividad física regular, acciones en caso de paro cardiorrespiratorio, la protección del paciente y del personal de salud así como las indicaciones precisas en el uso de la imagen cardiovascular no invasiva, la prescripción de medicamentos, cuidados en tópicos específicos como en la hipertensión arterial sistémica, insuficiencia cardiaca, arritmias y síndromes coronarios agudos, además de hacer énfasis en los procedimientos de electrofisiología, intervencionismo, cirugía cardiaca y en la rehabilitación cardiaca. El interés principal es brindar a la comunidad médica una orientación general sobre el quehacer en la práctica cotidiana y pacientes con enfermedades cardiovasculares en el escenario esta crisis epidemiológica sin precedentes de COVID-19.

https://doi.org/10.24875/acm.m20000057 445 downloads

La redefinición de lo posible: militancia política y movilización social en El Salvador (1970-2012). Por Kristina Pirker. México: Instituto de Investigaciones Dr. José María Luis Mora, 2017, 423 pp.
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Quintanilla Magaña, Ariel Alexander

Relaciones. Estudios de historia y sociedad

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2019, Volume 40 N. 160 Pages 221 - 223

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.24901/rehs.v40i160.681 64 downloads

Prevalencia de pacientes con tratamiento sustitutivo renal en El Salvador en 2014
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

García-Trabanino, Ramón

; Trujillo, Zulma

; Colorado, Ana Verónica

; Magaña Mercado, Salvador

; Henríquez, Carlos Atilio

Nefrología (Madrid)

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2016, Volume 36 N. 6 Pages 631 - 636

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract El Salvador has the highest renal failure mortality rate in the Americas. Five healthcare providers offer renal replacement therapy (RRT) in the country. The national RRT prevalence has never been reported. Aims: To determine the RRT prevalence in El Salvador and some basic characteristics. Methods: The association of nephrology coordinated a nationwide cross-sectional survey during the third quarter of 2014. 31 renal centres participated in the survey, covering 99.5% of patients. Results: National RRT prevalence: 595 per million population (pmp), N = 3807, average age 50.4 years, 67.5% male. By modality: peritoneal dialysis (PD) 289 pmp, haemodialysis (HD) 233 pmp, with functioning kidney transplantation 74 pmp (living donor only). Social security covers 25% of the population but treats 49.7% of RRT patients. Generally, higher prevalence was observed in municipalities with renal centres or located on the coast or lowlands. Ninety-five percent of HD patients receive fewer than 3 weekly sessions. Of PD patients, 59% do not belong to a continuous outpatient or automated programme, and 25% still use rigid catheter. Aetiology of chronic kidney disease: unavailable/undetermined 50%, hypertension 21.1%, diabetes 18.9%, glomerulonephritis 6.7%, obstructive causes 1.2%, tubulointerstitial 0.9%, polycystic 0.4% and other 0.7%. Discussion: Despite the increase in RRT services, the prevalence is lower than the Latin American average (660 pmp). Three quarters of HD and PD patients are under-dialysed. Obsolete RRT techniques are still used. The presence of Mesoamerican nephropathy influences the demographic characteristics (many young patients, two-thirds male, high prevalence in lowlands and coastlands).

Resumen El Salvador presenta la mortalidad por fallo renal más alta de América. Cinco proveedores de servicios de salud ofrecen tratamiento sustitutivo renal (TSR) en el país. La prevalencia nacional de TSR nunca ha sido reportada. Objetivos: Conocer la prevalencia de TSR en El Salvador y algunas características básicas. Métodos: La asociación de nefrología coordinó una encuesta nacional transversal durante el tercer trimestre de 2014; 31 centros renales participaron, que cubrían el 99,5% de los pacientes. Resultados: Prevalencia nacional de TSR: 595 por millón de población (pmp), N = 3.807, edad promedio 50,4 años, 67,5% hombres. Por modalidad: diálisis peritoneal (DP) 289 pmp; hemodiálisis (HD) 233 pmp; con trasplante renal funcionante 74 pmp (donante vivo solamente). La seguridad social cubre el 25% de la población, pero atiende al 49,7% de los pacientes en TSR. Generalmente observamos prevalencias más altas en municipios con centros renales, costeros o de zonas bajas. Un 95% de los pacientes en HD reciben menos de 3 sesiones semanales. Un 59% de los pacientes en DP no están en continua ambulatoria o programas automatizados y un 25% todavía utilizan catéter rígido. Etiología de la enfermedad renal crónica: no reportada/desconocida 50%, hipertensión 21,1%, diabetes 18,9%, glomerulonefritis 6,7%, obstructivas 1,2%, tubulointersticiales 0,9%, poliquísticas 0,4%, otras 0,7%. Discusión: A pesar del incremento de servicios de TSR, la prevalencia es inferior al promedio latinoamericano (660 pmp). Un 75% de los pacientes en HD y DP están infradializados. Todavía se utilizan técnicas anticuadas. La presencia de la nefropatía mesoamericana influye las características demográficas (muchos jóvenes, 2/3 hombres, alta prevalencia en zonas bajas y costeras).

https://doi.org/10.1016/j.nefro.2016.01.015 315 downloads

Concordancia entre la gasometría arterial y venosa central en sujetos postoperados de cirugía de revascularización miocárdica en condición estable
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics
- Dimensions
- PlumX
- Altmetric

Santos-Martínez, Luis Efren

; Guevara-Carrasco, Marlene

; Naranjo-Ricoy, Guillermo

; Baranda-Tovar, Francisco Martín

; Moreno-Ruíz, Luis Antonio

; Herrera-Velázquez, Marco Antonio

; Magaña-Serrano, José Antonio

; Valencia-Sánchez, Jesús Salvador

; Calderón-Abbo, Moisés Cutiel

Archivos de cardiología de México

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2014, Volume 84 N. 3 Pages 147 - 154

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Objective: The concordance between the parameters of arterial and central venous blood gases has not been defined yet. We studied the concordance between both parameters in post-surgical myocardial revascularization patients in stable condition. Methods: Consecutive subjects were studied in a cross-sectional design. The position of the central venous catheter was performed and simultaneously we obtained arterial and central venous blood samples prior to discharge from the intensive care unit. Data are expressed according to Bland-Altman statistical method and the intraclass correlation coefficient. Statistical result was accepted at P < .05. Results: Two hundred and six samples were studied of 103 post-surgical patients, pH and lactate had a mean difference (limits of agreement) 0.029 ± 0.048 (−0018, 0.077) and −0.12 ± 0.22 (−0.57, 0.33) respectively. The magnitude of the intraclass correlation coefficient was 0.904 and 0.943 respectively. The values related to oxygen pressure were 27.86 ± 6.08 (15.9, 39.8) and oxygen saturation 33.02 ± 6.13 (21, 45), with magnitude of 0.258 and 0.418 respectively. Conclusion: The best matching parameters between arterial and central venous blood samples were pH and lactate.

Objetivo: La concordancia entre los parámetros de la gasometría arterial y venosa central no se ha definido aún, por lo cual estudiamos la concordancia entre ambas en sujetos postoperados de cirugía de revascularización miocárdica en condición estable. Métodos: Se estudiaron sujetos de manera consecutiva con un diseño transversal. Se les determinó la posición del catéter venoso central y al mismo tiempo se obtuvo la muestra arterial y venosa central previa a su egreso de la terapia intensiva. Los datos se expresaron según el método estadístico de Bland-Altman y al coeficiente de correlación intraclase. El resultado estadístico aceptó una p < 0.05. Resultados: Se estudiaron 206 muestras de 103 sujetos postoperados, el pH y el lactato tuvieron una diferencia media (límites de acuerdo) de 0.029 ± 0.048 (−0.018, 0.077) y −0.12 ± 0.22 (−0.57, 0.33) respectivamente; la magnitud del coeficiente de correlación intraclase respectiva fue de 0.904 y 0.943; las relativas a la presión de oxígeno 27.86 ± 6.08 (15.9, 39.8) y la saturación de oxígeno 33.02 ± 6.13 (21, 45), magnitud 0.258 y 0.418. Conclusión: Los parámetros con mejor concordancia arterial y venosa central fueron el pH y el lactato.

https://doi.org/10.1016/j.acmx.2013.11.005 18103 downloads

Clinical characteristics of chronic kidney disease of nontraditional causes in Salvadoran farming communities
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Herrera, Raúl

; Orantes, Carlos M.

; Almaguer, Miguel

; Alfonso, Pedro

; Bayarre, Héctor D.

; Leiva, Irma M.

; Smith, Magaly J.

; Cubias, Ricardo A.

; MD, Carlos G. Torres

; Almendárez, Walter O.

; Cubias, Francisco R.

; Morales, Fabrizio E.

; Magaña, Salvador

; Amaya, Juan C.

; Perdomo, Edgard

; Ventura, Mercedes C.

; Villatoro, Juan F.

; Vela, Xavier F.

; Zelaya, Susana M.

; Granados, Delmy V.

; Vela, Eduardo

; Orellana, Patricia

; Hevia, Reynaldo

; Fuentes, E. Jackeline

; Mañalich, Reinaldo

; Bacallao, Raymed

; Ugarte, Mario

; Arias, María I.

; Chávez, Jackelin

; Flores, Nelson E.

; Aparicio, Claudia E.

MEDICC Review

Journal Metrics
- Sobre o periódico
- SciELO Analytics

apr 2014, Volume 16 N. 2 Pages 39 - 48

Abstract: En | Text: En | PDF: En

INTRODUCTION: Chronic kidney disease is a serious health problem in El Salvador. Since the 1990s, there has been an increase in cases unassociated with traditional risk factors. It is the second leading cause of death in men aged >18 years. In 2009, it was the first cause of in-hospital death for men and the fifth for women. The disease has not been thoroughly studied. OBJECTIVE: Characterize clinical manifestations (including extrarenal) and pathophysiology of chronic kidney disease of nontraditional causes in Salvadoran farming communities. METHODS: A descriptive clinical study was carried out in 46 participants (36 men, 10 women), identified through chronic kidney disease population screening of 5018 persons. Inclusion criteria were age 18 - 59 years; chronic kidney disease at stages 2, 3a and 3b, or at 3a and 3b with diabetes or hypertension and without proteinuria; normal fundoscopic exam; no structural abnormalities on renal ultrasound; and HIV-negative. Examinations included social determinants; psychological assessment; clinical exam of organs and systems; hematological and biochemical parameters in blood and urine; urine sediment analysis; markers of renal damage; glomerular and tubular function; and liver, pancreas and lung functions. Renal, prostate and gynecological ultrasound; and Doppler echocardiography and peripheral vascular and renal Doppler ultrasound were performed. RESULTS: Patient distribution by chronic kidney disease stages: 2 (32.6%), 3a (23.9%), 3b (43.5%). Poverty was the leading social determinant observed. Risk factor prevalence: agrochemical exposure (95.7%), agricultural work (78.3%), male sex (78.3%), profuse sweating during work (76.3%), malaria (43.5%), NSAID use (41.3%), hypertension (36.9%), diabetes (4.3%). General symptoms: arthralgia (54.3%), asthenia (52.2%), cramps (45.7%), fainting (30.4). Renal symptoms: nycturia (65.2%), dysuria (39.1%), foamy urine (63%). Markers of renal damage: macroalbuminuria (80.4%), β2 microglobulin (78.2%), NGAL (26.1%). Renal function: hypermagnesuria (100%), hyperphosphaturia (50%), hypernatriuria (45.7%), hyperkaluria (23.9%), hypercalciuria (17.4%), electrolyte polyuria (43.5%), metabolic alkalosis (45.7%), hyponatremia (47.8%), hypocalcemia (39.1%), hypokalemia (30.4%), hypomagnesemia (19.6%). Imaging: Ultrasound showed fatty liver (93.5%) and vascular Doppler showed tibial artery damage (66.7%). Neurological symptoms: abnormal tendon reflexes (45.6%), Babinski sign and myoclonus (6.5%), sensorineural hearing loss (56.5%). CONCLUSIONS: This chronic kidney disease studied behaves clinically like chronic tubulointerstitial nephropathy, but with systemic manifestations not attributable to kidney disease. While male agricultural workers predominated, women and adolescents were also affected. Findings support a hypothesis of multifactorial etiology with a key role played by nephrotoxic environmental agents.

1846 downloads

Histopathology of chronic kidney disease of unknown etiology in Salvadoran agricultural communities
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

López-Marín, Laura

; Chávez, Yudit

; García, Xenia A.

; Flores, Walter M.

; García, Yesenia M.

; Herrera, Raúl

; Almaguer, Miguel

; Orantes, Carlos M.

; Calero, Denis

; Bayarre, Héctor D.

; Amaya, Juan Carlos

; Magaña, Salvador

; Espinoza, Paul A.

; Serpas, Lisbeth

MEDICC Review

Journal Metrics
- Sobre o periódico
- SciELO Analytics

apr 2014, Volume 16 N. 2 Pages 49 - 54

Abstract: En | Text: En | PDF: En

INTRODUCTION: For at least a decade, a chronic kidney disease unassociated with diabetes mellitus, hypertension or any of the more common traditional causes, has been reported in Salvadoran agricultural communities. OBJECTIVE: Characterize histopathology of chronic kidney disease of unknown etiology in patients from Salvadoran agricultural communities, describe renal damage associated with each disease stage, and assess associations between histopathological alterations and sociodemographic variables. METHODS: The study involved 46 patients of both sexes, aged ≥18 years. After clinical, laboratory and imaging examinations, kidney biopsies were performed and renal tissue assessed for interstitial fibrosis, tubular atrophy, interstitial inflammatory infiltration, sclerosis, increase in glomerular size and extraglomerular vascular lesions (according to the Banff 97 classification used for kidney transplant rejection). Special staining was done: Schiff periodic acid, Masson trichrome and methenamine silver. Immunofluorescence techniques were used to evaluate IgA, IgG, IgM, complement C1q and C3, fibrin, and kappa and lambda light chain deposits. RESULTS: The main findings were interstitial fibrosis and tubular atrophy with or without inflammatory monocyte infiltration. In addition, generalized sclerosis, increased glomerular size, collapse of some glomerular tufts, and lesions of extraglomerular blood vessels (such as intimal proliferation and thickening and vacuolization of the tunica media) were observed. Interstitial fibrosis and glomerulosclerosis were associated with male sex. Sugarcane workers showed more interstitial fibrosis and tubular atrophy and less glomerulomegaly than other occupational groups. CONCLUSION: The morphological pattern in all biopsies was one of chronic tubulointerstitial nephropathy with secondary glomerular and vascular damage, in different stages of evolution of chronic kidney disease, independent of age, sex or occupation.

1740 downloads

Seeds stored in the forest floor in a natural stand of Pinus montezumae Lamb.
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Carrillo-Anzures, Fernando

; Vera-Castillo, Gil

; Salvador Magaña-Torres, Octavio

; Guldin, Jim M.

; Guries, Raymond P.

Ciencia forestal en México

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2009, Volume 34 N. 106 Pages 41 - 60

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Seed banks have been studied to a greater extent in agriculture than in forestry due to long-standing concerns about the threat to agricultural crops posed by weed species. However, in forest areas seed banks have an important influence on plant succession since the vegetation that colonizes a space after a major disturbance will arise at least partly from them. Knowledge about this condition can help land managers to prescribe site treatments that produce desired vegetation from the perspectives of wildlife habitat, reduced plant competition with crop tree species, and related management concerns. The variability of the soil seed bank of a Pinus montezumae forest was assessed using seedling-emergence method for soil samples. The number of species and seedling abundance were evaluated by sampling four plots in a natural regeneration area. A total of 43 species were recorded in the seed bank (2 trees, 17 shrubs, 1 grass and 23 herbs). Viable seeds of most species were contained in similar abundance in the humus and mineral soil layers. Dominant species in the stand (P. montezumae) and codominant species (P. ayacahuite, Abies religiosa, and Alnus firmifolia) were poorly represented in the soil seed bank which was dominated by seeds of an array of annual and perennial herbs. Regeneration of commercial species under any silvicultural method must come from current seed production, or seed produced off site, but not from the soil seed bank.

Los bancos de semillas han sido estudiados más en la agricultura que en el área forestal debido a la preocupación sobre el peligro de que los cultivos sean dominados por malas hierbas. Tienen una gran influencia en la sucesión vegetal que coloniza un área después de un disturbio. El conocimiento sobre bancos de semillas en el suelo puede ayudar a prescribir los tratamientos que propicien condiciones de vegetación deseadas desde la perspectiva de hábitat de fauna silvestre, reducción de competencia con especies de importancia y otros problemas relacionados con el manejo forestal. La variación del banco de semillas en el suelo de un bosque de Pinus montezumae fue evaluado por medio del método de emergencia en muestras de suelo; se determinó la abundancia y el número de taxa mediante el muestreo en cuatro parcelas en un área de regeneración natural. Los resultados indican 43 especies (dos de árboles, 17 de arbustos, una de pasto y 23 de hierbas). La abundancia de semillas viables fue similar para la mayoría de ellas en la capa de humus y suelo mineral; en tanto que las dominantes del rodal (P. montezumae) y codominantes (P. ayacahuite, Abies religiosa y Alnus firmifolia), no estuvieron presentes en el banco, en el cual dominaron herbáceas anuales y perennes. La regeneración de las especies comerciales para este tipo de bosque, bajo cualquier método silvícola, debe provenir de semilla producida en el año in situ o de áreas aledañas, pero no del banco de semillas.

4129 downloads Cited 3 times in SciELO

El cedro rojo (Cedrela odorata L.) como alternativa de reconversión de terrenos agrícolas en el sur de Tamaulipas
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Ramírez-García, Celene

; Vera-Castillo, Gil

; Carrillo-Anzures, Fernando

; Magaña-Torres, Octavio Salvador

Agricultura técnica en México

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2008, Volume 34 N. 2 Pages 243 - 250

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

The productive reconversion implies to modify the pattern of traditional production, through the establishment of alternative crops with higher agronomic viability, economic profitability and social viability. A reconversion option is the establishment of forest plantations. The objective of this work was to determine the feasibility of converting abandoned agricultural lands in commercial forest plantations, the study was conduced from 2000-2003. This feasibility was determined through the assessment of the survival, growth, health and vigour of a plantation of red cedar (Cedrela odorata L.) located in the Ejido Doroteo Arango, Tamaulipas. At three years of established the plantation, a survival of 93%, a growth diameter average of 1.72 cm and 1.46 m in height was found. Although attack of Hypsipyla grandella, 90.3% were healthy trees and the proportion of vigorous trees was 84.36%. The obtained values of survival, growth, sanity and vigour of the assessed plantation show that the red cedar has a good adaptation and growth; this allow to affirm that the establishment of commercial forest plantations of cedar in the south of Tamaulipas is a good option for abandoned agricultural lands.

La reconversión productiva implica modificar el patrón de producción tradicional, mediante el establecimiento de cultivos alternativos con mayor alternativa agronómica, rentabilidad económica y viabilidad social. Una opción de reconversión es el establecimiento de plantaciones forestales. El objetivo de este trabajo fue determinar la factibilidad de convertir terrenos agrícolas abandonados en plantaciones forestales comerciales, el estudio fue conducido de 2000-2003. Esta factibilidad se determinó mediante la evaluación de la supervivencia, el crecimiento, estado de sanidad y vigor de una plantación de cedro rojo (Cedrela odorata L.) ubicada en el Ejido Doroteo Arango, Tamaulipas. Los resultados del muestreo señalaron que, a tres años de establecida la plantación, se tiene una supervivencia de 93%, un crecimiento promedio en diámetro de 1.72 cm y 1.46 m en altura. Aún cuando se tuvo ataque de Hypsipyla grandella (Zeller), la proporción de árboles sanos es de 90.3% y la proporción de árboles vigorosos de 84.36%. Los valores obtenidos de supervivencia, crecimiento, sanidad y vigor muestran que el cedro rojo tiene una buena adaptación y crecimiento; lo que permite afirmar que el establecimiento de plantaciones forestales comerciales de cedro en el sur de Tamaulipas es una opción viable para reconvertir terrenos agrícolas abandonados.

35350 downloads Cited 2 times in SciELO

Polyamines as biomarkers of the antitumoral activity of bursera fagaroides
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Reynoso-Orozco, Ramón

; Santerre, Anne

; Delgado-Saucedo, Jorge Iván

; Casas Solís, Josefina

; Velázquez-Magaña, Salvador

; Puebla-Pérez, Ana María

Interciencia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

may 2008, Volume 33 N. 5 Pages 384 - 388

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

En células normales y tumorales las poliaminas (PAs) putresina (Pu), espermidina (Spd) y espermina (Spm) son requeridas en múltiples funciones fundamentales del ciclo celular. Altos niveles de Pas han sido reportados en varios tipos de cáncer, por lo que han sido propuestas como biomarcadores del desarrollo tumoral. En el presente trabajo se reporta su utilidad como biomarcadores de la evolución del linfoma murino L5178Y en diferentes fluidos, células y tejidos. Los hallazgos también fueron aplicados al seguimiento del efecto antitumoral de Bursera fagaroides, ya reportado previamente. Se utilizó cromatografía de intercambio iónico para determinar los niveles de PAs en orina, células peritoneales, linfocitos circulantes, esplenocitos, mesotelio e hígado de ratones BALB/c a los 10, 17 y 24 días de evolución del tumor y de ratones tratados con el extracto hidroalcohólico de la corteza de B. fagaroides administrado por vía oral o intaperitonealmente (i.p.) Los niveles urinarios de Spd y Spm no fueron detectables, mientras que el incremento de Pu en orina es el mejor biomarcador del crecimiento del linfoma. Además, los niveles urinarios de Pu disminuyeron significativamente en ratones tratados intraperitonealmente con B. fagaroides, lo cual refuerza resultados anteriores. En este modelo la variación de los niveles urinarios de Pu es un biomarcador efectivo del desarrollo neoplásico, dado que permite seguir la evolución del linfoma L5178Y. Además, proporciona una herramienta para estudiar in vivo, el efecto antitumoral de B. fagaroides y de otros fármacos.

In normal and tumoral cells, the polyamines (PAs) putrescine (Pu), spermidine (Spd) and spermine (Spm) are required in multiple fundamental cell cycle functions. High levels of PAs have been reported in many types of cancer, which is why they were proposed as biomarkers of cancer growth. In the present work, their utility as biomarkers of the evolution of the murine L5178Y lymphoma is reported in different body fluids, cells and tissues. Findings were also applied to the follow-up of the previously reported anti-tumor effect of Bursera fagaroides. Cation exchange chromatography was used to determine the PAs levels in urine, peritoneal cells, circulating lymphocytes, spleenocytes, mesothelium and liver of BALB/c mice at days 10, 17 and 24 of tumoral evolution. PAs levels were also measured in urine from mice treated, intraperitoneally or orally, with the hydroalcoholic extract of the bark of B. fagaroides. Spd and Spm urinary levels were not detectable, while Pu increase in urine is the best biomarker to detect lymphoma growth. Furthermore, Pu urinary levels decreased significantly in mice treated intraperitoneally with B. fagaroides. In this model, variations of the Pu urinary level is an effective biomarker of neoplastic growth as it allows to follow the evolution of L5178Y lymphoma, providing an in vivo assay for the antitumoral effect of B. fagaroides and other drugs.

Em células normais e tumorais as poliaminas (PAs) putrescina (Pu), espermidina (Spd) e espermina (Spm) são requeridas em múltiples funções fundamentais do ciclo celular. Altos níveis de Pas têm sido relatados em vários tipos de câncer, pelo que tem sido propostas como biomarcadores do desenvolvimento tumoral. No presente trabalho se relata sua utilidade como biomarcadores da evolução do linfoma murino L5178Y em diferentes fluídos, células e tecidos. As descobertas também foram aplicadas ao seguimento do efeito antitumoral de Bursera fagaroides, já relatado previamente. Utilizou-se cromatografia de intercambio iônico para determinar os níveis de PAs em urina, células peritoneais, linfócitos circulantes, esplenócitos, mesotélio e fígado de ratos BALB/c aos 10, 17 e 24 dias de evolução do tumor e de ratos tratados com o extrato hidroalcoólico da camada de B. fagaroides administrado por via oral ou i.p. Os níveis urinários de Spd e Spm não foram detectáveis, enquanto que o incremento de Pu na urina é o melhor biomarcador do crescimento do linfoma. Além disso, os níveis urinários de Pu diminuíram significativamente em ratos tratados intraperitonealmente com B. fagaroides, o qual reforça resultados anteriores. Neste modelo a variação dos níveis urinários de Pu são um biomarcador efetivo do desenvolvimento neoplásico, devido a que permite seguir a evolução do linfoma L5178Y. Alem disso, proporciona uma ferramenta para estudar in vivo, o efeito antitumoral de B. fagaroides e de outros fármacos.

358 downloads Cited 1 time in SciELO

10.

I Diretriz Latino-Americana para avaliação e conduta na insuficiência cardíaca descompensada
Facebook Twitter

Other social networks
Google+
LinkedIn
Reddit
StambleUpon
CiteULike
Mendeley
Other networks

Metrics
- SciELO Analytics

Bocchi, Edimar Alcides

; Vilas-Boas, Fábio

; Perrone, Sergio

; Caamaño, Angel G

; Clausell, Nadine

; Moreira, Maria da Consolação V

; Thierer, Jorge

; Grancelli, Hugo Omar

; Serrano Junior, Carlos Vicente

; Albuquerque, Denilson

; Almeida, Dirceu

; Bacal, Fernando

; Moreira, Luís Felipe

; Mendonza, Adonay

; Magaña, Antonio

; Tejeda, Arturo

; Chafes, Daniel

; Gomez, Efraim

; Bogantes, Erick

; Azeka, Estela

; Mesquita, Evandro Tinoco

; Reis, Francisco José Farias B

; Mora, Hector

; Vilacorta, Humberto

; Sanches, Jesus

; Souza Neto, David de

; Vuksovic, José Luís

; Paes Moreno, Juan

; Aspe y Rosas, Júlio

; Moura, Lidia Zytynski

; Campos, Luís Antonio de Almeida

; Rohde, Luis Eduardo

; Parioma Javier, Marcos

; Garrido Garduño, Martin

; Tavares, Múcio

; Castro Gálvez, Pablo

; Spinoza, Raul

; Miranda, Reynaldo Castro de

; Rocha, Ricardo Mourilhe

; Paganini, Roberto

; Guerra, Rodolfo Castano

; Rassi, Salvador

; Lagudis, Sofia

; Bordignon, Solange

; Navarette, Solon

; Fernandes, Waldo

; Barretto, Antonio Carlos Pereira

; Issa, Victor

; Guimarães, Jorge Ilha

Arquivos Brasileiros de Cardiologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

sep 2005, Volume 85 Suppl. 3 Pages 1 - 48

Abstract: Pt | Text: Pt | PDF: Pt

38786 downloads Cited 2 times in SciELO

Showing

itens per page

Page of 1 Next

Select one or more results

All Alphabetic

Results

Comparative chart Download CSV

Statistics of

Send result

To*

Use ; (semicolon) to insert more emails.

Send to email

This page

Selected records

All references (max. 300)

Your email

Subject

Comments

Export format:

RIS (for EndNote, ProCite, Reference Manager, RefWorks, Citavi, etc.)

BibTeX

Citation

CSV (for Excel, etc)

Export:

This page

Selected itens

All references (max. 2000)

Sem resultados

No documents were found for your search

Glossary and search help

You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.

For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

See below the complete list of search indexes that can be used:

Index code	Element
ti	article title
au	author
kw	article keywords
subject	subject (title words, abstract and keywords)
ab	abstract
ta	journal short title (e.g. Cad. Saúde Pública)
journal_title	journal full title (e.g. Cadernos de Saúde Pública)
la	publication language code (e.g. pt - Portuguese, es - Spanish)
type	document type
pid	publication identifier
publication_year	publication year of publication
sponsor	sponsor
aff_country	country code of the author's affiliation
aff_institution	author affiliation institution
volume	article volume
issue	article issue
elocation	elocation
doi	DOI number
issn	journal ISSN
in	SciELO colection code (e.g. scl - Brasil, col - Colômbia)
use_license	article usage license code

SciELO - Scientific Electronic Library Online
Rua Dr. Diogo de Faria, 1087 – 9º andar – Vila Clementino 04037-003 São Paulo/SP - Brasil
Email: scielo@scielo.org

All the contents of this site www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.
more »