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Resumo Objetivos: avaliar a associação entre o consumo de alimentos ultraprocessados por gestantes e o peso de recém-nascidos. Métodos: estudo prospectivo com gestantes (n=214) selecionadas em Unidades Básicas de Saúde em Pinhais, Paraná. Dados socioeconômicos, demográfcos e de saúde foram coletados. Dados de consumo alimentar foram coletados por recordatório de 24-horas físico e entrados no software GloboDiet. O consumo diário relativo de energia proveniente de alimentos ultraprocessados foi estimado e a análise de regressão logística foi utilizada, considerando covariáveis como renda familiar e escolaridade. Resultados: o consumo de alimentos ultraprocessados pelas gestantes representou 26,9% da energia total. Cerca de 5,7% de recém-nascidos foram classifcados como pequenos para idade gestacional (PIG) e 10,7% como grandes para idade gestacional (GIG). Foi observada uma associação estatisticamente signifcativa limítrofe entre o peso dos recém-nascidos GIG e o consumo materno de alimentos ultraprocessados (OR= 1,027; p=0,048). Além disso, a renda familiar esteve associada com o consumo de alimentos ultraprocessados (OR=0,144; p=0,008). A cada 1% adicional de consumo de alimentos ultraprocessados, a probabilidade de as mães terem recém-nascidos GIG aumentou cerca de 2,7%. Conclusões: o estudo revela uma tendência de associação positiva entre o peso de recém-nascidos GIG e o consumo de alimentos ultraprocessados por mulheres grávidas, mas não para crianças PIG. Objetivos recémnascidos. recémnascidos recém nascidos. nascidos Métodos n=214 n214 n 214 (n=214 Pinhais Paraná socioeconômicos 24horas horas 24 GloboDiet utilizada escolaridade Resultados 269 26 9 26,9 total 57 5 7 5,7 PIG (PIG 107 10 10,7 GIG. . (GIG) OR= OR (OR 1,027 1027 1 027 p=0,048. p0048 p p=0,048 0 048 p=0,048) disso OR=0,144 OR0144 144 (OR=0,144 p=0,008. p0008 p=0,008 008 p=0,008) 27 2 2,7% Conclusões grávidas n=21 n21 21 (n=21 26, 5, 10, (GIG 1,02 102 02 p004 p=0,04 04 OR=0,14 OR014 14 (OR=0,14 p000 p=0,00 00 2,7 n=2 n2 (n=2 1,0 p00 p=0,0 OR=0,1 OR01 (OR=0,1 2, n= (n= 1, p0 p=0, OR=0, OR0 (OR=0, (n p=0 OR=0 (OR=0 p=

Abstract Objectives: to assess the association between pregnant women’s consumption of ultra-processed foods and newborn body weight. Methods: prospective study with pregnant women (n=214) selected from all Basic Health Units in the city of Pinhais, Paraná. Socioeconomic, demographic, and health data were collected. Food consumption data were assessed using a 24-hour dietary recall and tabulated with GloboDiet software. Daily relative energy intake of ultra-processed food was estimated and logistic regression analysis was utilized. The infuence of covariates on the association analysis was also explored (e.g., income and education). Results: ultra-processed foods contributed to 26.9% of pregnant women’s total energy intake. About 5.7% of newborns were classifed as small-for-gestational-age and 10.7% as large-for-gestational-age. A borderline statistically signifcant association was observed between large-for-gestational-age newborn weight and maternal consumption of ultra-processed foods (OR= 1.027; p=0.048). Additionally, family income was associated with the consumption of ultra-processed foods (OR= 0.144; p=0.008). With each additional 1% consumption of ultra-processed foods, mothers’ likelihood of having large-for-gestational-age babies increased by about 2.7%. Conclusions: the study reveals a trend of positive association between the weight of large-for-gestational-age newborns and the consumption of ultra-processed foods by pregnant women, but not for small-for-gestational-age children. Objectives womens s ultraprocessed ultra processed Methods n=214 n214 n 214 (n=214 Pinhais Paraná Socioeconomic demographic collected 24hour hour 24 software utilized e.g., eg e g (e.g. education. education . education) Results 269 26 9 26.9 57 5 7 5.7 smallforgestationalage small gestational age 107 10 10.7 largeforgestationalage. largeforgestationalage large age. OR= OR (OR 1.027 1027 1 027 p=0.048. p0048 p p=0.048 0 048 p=0.048) Additionally 0.144 0144 144 p=0.008. p0008 p=0.008 008 p=0.008) mothers 27 2 2.7% Conclusions children n=21 n21 21 (n=21 e.g. (e.g 26. 5. 10. 1.02 102 02 p004 p=0.04 04 0.14 014 14 p000 p=0.00 00 2.7 n=2 n2 (n=2 e.g 1.0 p00 p=0.0 0.1 01 2. n= (n= 1. p0 p=0. 0. (n p=0 p=

https://doi.org/10.1590/1806-9304202400000189-en

Identification and antimicrobial susceptibility profile of bacteria isolated from primary endodontic infections
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MARIANO, Lorena Souza Santos

; NAKAMURA-SILVA, Rafael

; MACEDO, Luciana Martins Domingues de

; OLIVEIRA-SILVA, Mariana de

; GOULART, Rafael da Silva

; PELISSON, Marsileni

; VESPERO, Eliana Carolina

; SILVA-SOUSA, Yara Teresinha Correa

; PITONDO-SILVA, André

Brazilian Oral Research

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2024, Volume 38 elocation e024

Abstract: En | Text: En | PDF: En

Abstract This study aimed to identify and characterize the antimicrobial susceptibility profile of bacteria found in primary endodontic infections in the teeth of patients treated at the Dental Clinic of the University of Ribeirão Preto, São Paulo, Brazil. From September to December 2019, samples were obtained from 21 patients with primary endodontic infections. The collections were carried out in triplicate using paper cones placed close to the total length of the root canal. Bacterial isolation was performed in Brain Heart Infusion agar, Blood agar, and other selective culture media cultured at 37°C for up to 48 h under aerobiosis and microaerophilic conditions. The bacterial species were identified using the Vitek 2 automated system. The disk diffusion method on agar Müeller–Hinton was used to assess antimicrobial susceptibility with the recommended antimicrobials for each identified bacterial species. A total of 49 antibiotics were evaluated. Fifteen of the 21 samples collected showed bacterial growth, and 17 bacterial isolates were found. There were 10 different bacterial species identified: Enterococcus faecalis (four isolates), Streptococcus mitis/oralis (three isolates), Streptococcus anginosus (three isolates) being the most common, followed by Staphylococcus epidermidis, Enterococcus faecium, Streptococcus constellatus, Streptococcus alactolyticus, Enterobacter cloacae, Klebsiella variicola, and Providencia rettgeri (one isolate of each species). The analysis demonstrated significant susceptibility to most of the tested antibiotics. However, some Enterococcus isolates resisted the antibiotic’s erythromycin, ciprofloxacin, and tetracycline. A Staphylococcus epidermidis isolate was characterized as multidrug-resistant. Five Streptococcus isolates were non-susceptible to all antibiotics tested. Preto Paulo Brazil 2019 canal 37C C 37 4 conditions system MüellerHinton Müeller Hinton evaluated growth 1 four isolates, , mitisoralis mitis oralis three common faecium constellatus alactolyticus cloacae variicola one . species) However antibiotic s erythromycin ciprofloxacin tetracycline multidrugresistant. multidrugresistant multidrug resistant. resistant multidrug-resistant nonsusceptible non susceptible 201 3 20

https://doi.org/10.1590/1807-3107bor-2024.vol38.0024

Methodological aspects in the food consumption assessment of pregnant women in the Multicenter Study of Iodine Deficiency
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Crispim, Sandra Patricia

; Silva, Débora Letícia Frizzi

; Macedo, Mariana de Souza

; Almeida, Claudia Choma Bettega

; Elias, Vanessa Cardozo Mendes

; Franceschini, Sylvia do Carmo Castro

Revista de Nutrição

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2024, Volume 37 elocation e230146

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Descrever com detalhes os aspectos metodológicos utilizados na avaliação do consumo alimentar de gestantes no Estudo Multicêntrico de Deficiência de Iodo para otimizar a reprodutibilidade deste e outros estudos. Métodos O Recordatório 24-horas foi utilizado como ferramenta para a avaliação do consumo alimentar de gestantes (n=2.247), em amostra de abrangência nacional. O método utilizado foi adaptado para aplicação no papel, seguido pela inserção dos dados no software GloboDiet. Em seguida, procedeu-se à verificação de notas de inconsistência e controle de qualidade dos dados (por exemplo, análise de Goldberg). Os alimentos também foram categorizados conforme a classificação NOVA e por grupos alimentares. Resultados Vários desafios foram observados na avaliação do consumo alimentar: adaptação da coleta no papel para entrada de dados no software, falta de composição de dados de iodo, dentre outros. Não obstante, destaca-se a padronização e detalhamento de dados coletados e gerados, bem como os tipos de medidas dietéticas que poderão ser geradas a partir dos bancos criados. Conclusão Acredita-se que o compartilhamento dessas informações pode favorecer a harmonização de dados dietéticos, bem como a comparação das evidências geradas entres os estudos brasileiros. 24horas horas 24 n=2.247, n2247 n n=2.247 , 2 247 (n=2.247) nacional GloboDiet seguida procedeuse procedeu se exemplo Goldberg. Goldberg . Goldberg) alimentares iodo obstante destacase destaca gerados criados Acreditase Acredita dietéticos brasileiros n224 n=2.24 (n=2.247 n22 n=2.2 (n=2.24 n2 n=2. (n=2.2 n=2 (n=2. n= (n=2 (n= (n

ABSTRACT Objective To describe in detail the methodological aspects used in the assessment of food consumption of pregnant women within the Multicenter Study of Iodine Deficiency to streamline the reproducibility of this work and other studies. Methods The 24-hour dietary recall (24hR) was used to assess pregnant women’s dietary intake (n=2,247) in a nationwide sample. The method was adapted for paper application, followed by data entry in the GloboDiet software. Subsequently, the data were verified for inconsistencies and submitted to quality control (e.g., Goldberg analysis). Foods were also categorized under the NOVA classification and food groups. Results Several challenges were observed in the study: adaptation of the print format-based data collection for the software data entry and the lack of iodine data composition. However, some potentialities of the collected data stand out, including the standardized, detailed collected data and the types of dietary indicators that can be generated from the created databases. Conclusion We expect the shared information to favor data harmonization and, therefore, enable the comparison of evidence generated among Brazilian studies. studies 24hour hour 24 24hR hR (24hR womens s n=2,247 n2247 n 2 247 (n=2,247 sample application Subsequently e.g., eg e g (e.g. analysis. analysis . analysis) groups study formatbased format based composition However out standardized databases therefore n=2,24 n224 (n=2,24 e.g. (e.g n=2,2 n22 (n=2,2 e.g n=2, n2 (n=2, n=2 (n=2 n= (n= (n

https://doi.org/10.1590/1678-9865202437e230146

COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020: study protocol and initial results
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Meireles, Adriana Lúcia

; Garcia Lourenção, Luciano

; Alves de Menezes Júnior, Luiz Antônio

; Nascimento Coletro, Hillary

; Sousa Justiniano, Irene Carolina

; Silva de Moura, Samara

; Popolino Diniz, Amanda

; da Silva Sabião, Thaís

; Sampaio Rocha, Ana Maria

; Batista, Aline Priscila

; Nunes Lage, Nara

; dos Santos Simões, Bárbara

; Ali Santos, Carolina

; de Deus Mendonça, Raquel

; de Souza Andrade, Amanda Cristina

; Furbino Barbosa, Keila

; Zumerle Masioli, Cássio

; Cardoso Carraro, Júlia Cristina

; Carvalho de Menezes, Mariana

; Rezende Macedo Nascimento, Renata Cristina

; Roever, Leonardo

; Teixeira Caiaffa, Waleska

; Lins Machado Coelho, George Luiz

Población y Salud en Mesoamérica

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dec 2023, Volume 21 N. 1 Pages 15 - 37

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Objective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.

Resumen Describir el protocolo de estudio y los resultados iniciales del proyecto de investigación COVID Inconfidentes. Método: Este artículo describe los procedimientos metodológicos adoptados y la prevalencia de la infección por SARS-CoV-2 en la población. Se realizó una encuesta domiciliaria entre octubre y diciembre de 2020, en dos ciudades históricas de la región minera de Brasil. El anticuerpo anti-SARS-CoV-2 se detectó mediante la prueba rápida Wondfo®. La entrevista cara a cara consistió en la administración de un cuestionario que contenía datos de registro, variables sociodemográficas y económicas, hábitos de vida, estado general de salud, salud mental, hábitos de sueño, alimentación y nutrición. Resultados: Se evaluaron 1.762 habitantes, de los cuales 764 (43,4 %) estaban en Mariana y 998 (56,6 %) en Ouro Preto. Para ambas ciudades, el 51,9 % de los entrevistados eran del sexo femenino, con predominio del rango de edad de 35 a 59 años (47,2 %). La prevalencia de la infección por SARS-CoV-2 fue del 5,5 % en ambos municipios, del 6,2 % en Ouro Preto y del 4,7 % en Mariana (p > 0,05). Conclusión: El estudio fue efectivo para estimar la seroprevalencia de infección por el virus y sus hallazgos permitirán analizar más las condiciones de salud de la población relacionadas con el aislamiento social y el riesgo de infección por SARS-CoV-2.

https://doi.org/10.15517/psm.v21i1.53127

Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review
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Lino, Ramon de Souza

; Silva, Mariana Sousa de Pina

; Jesus, Daniel Simões de

; Macedo, Rodrigo Colares de

; Lagares, Laura Souza

; Santos, Felipe Nunes Almeida dos

; Almeida, Luiz Alberto Bastos de

; Bomfim, Eric Simas

; Santos, Clarcson Plácido Conceição dos

Sao Paulo Medical Journal

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feb 2023, Volume 141 N. 1 Pages 78 - 86

Abstract: En | Text: En | PDF: En

Abstract BACKGROUND: Severe acute respiratory syndrome coronavirus 2 has several mechanisms of action related to inflammatory responses, especially in individuals diagnosed with obesity. This hyperinflammatory clinical profile resulting from the association between obesity and coronavirus disease 2019 (COVID-19) may be attenuated by regular physical activity. OBJECTIVE: The aim of this study was to review the evidence on the consequences of physical inactivity and physical activity on COVID-19 in patients with obesity. DESIGN AND SETTING: Narrative review at the Bahiana School of Medicine and Public Health in Salvador, Brazil. METHODS: We searched evidence on the association of COVID-19 with physical activity and obesity using the following keywords: “covid-19,” “physical activity,” and “obesity”. The databases used were MEDLINE (PubMed), ScienceDirect, and Virtual Health Library. Studies published from 2019 to 2021 and available in Portuguese, English, and Spanish were included. The final search was conducted on September 26, 2021. RESULTS: We identified 661 studies in the database, among which 71 were considered for inclusion in the narrative review of the molecular aspects of COVID-19 and its relationship with physical activity and obesity. CONCLUSION: This literature review enabled the perception of the relationship between the molecular mechanisms of COVID-19 and obesity. Regular physical activity had various benefits for the inflammatory condition of the studied population, highlighting moderate-intensity.

https://doi.org/10.1590/1516-3180.2021.1038.r1.06072022

Associação entre Hipertensão Arterial Sistêmica com Marcadores Laboratoriais, Composição Corporal, Apneia Obstrutiva do Sono e Variabilidade da Frequência Cardíaca em Adultos Obesos Laboratoriais Corporal
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Santos, Clarcson Plácido Conceição

; Lagares, Laura Souza

; Santos, Sarah Rafaela Mascarenhas

; Silva, Mariana Sousa de Pina

; Macedo, Rodrigo Colares de

; Almeida, Luiz Alberto Bastos de

; Bomfim, Eric Simas

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 7 elocation e20220728

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A hipertensão arterial sistêmica (HAS) é uma doença multifatorial, altamente prevalente e associada a riscos à saúde. Objetivo O objetivo deste estudo foi investigar a associação entre HAS e marcadores laboratoriais, antropométricos, de variabilidade da frequência cardíaca (VFC) e de apneia obstrutiva do sono e, em segundo plano, analisar a sensibilidade e especificidade das variáveis que são fatores independentes na associação. Métodos Estudo transversal com 95 pacientes obesos atendidos em um ambulatório de referência em obesidade em Salvador, BA, Brasil. Os dados da HAS foram obtidos dos prontuários eletrônicos. A amostra foi estratificada em Grupo Normotenso (GN) e Grupo Hipertenso (GH), sendo medidos marcadores laboratoriais, composição corporal, polissonografia e VFC para avaliar a associação da HAS com as variáveis preditoras. Para as análises, adotou-se p<0,05. Resultados A média da idade do GN foi de 36,3 ± 10,1 e GH 40,4 ± 10,6 anos, 73,7% eram mulheres no GN e 57,9% no GH; 82,4% no GH apresentavam resistência à insulina. No modelo de regressão logística multivariado com ajustes para idade, sexo, altura e saturação de oxi-hemoglobina, a HAS foi inversamente associada à glicose plasmática em jejum mg/dL (odds ratio [OR] = 0,96; intervalo de confiança de 95% [IC] = 0,92-0,99) e área de gordura visceral (AGV) cm2 (OR = 0,98; IC 95% = 0,97-0,99). A área sob a curva AGV foi de 0,728; IC 95% (0,620-0,836) e glicemia de jejum 0,693; IC 95% (0,582-0,804). Conclusão Menores concentrações de AGV e glicemia de jejum foram inversamente associadas à HAS. Além disso, tanto a glicemia de jejum quanto o AGV mostraram alta sensibilidade para triagem de HAS. (HAS multifatorial saúde laboratoriais antropométricos (VFC plano 9 Salvador BA Brasil eletrônicos (GN GH, , (GH) corporal preditoras análises adotouse adotou se p005 p 0 05 p<0,05 363 36 3 36, 101 10 1 10, 404 40 4 40, 106 6 anos 737 73 7 73,7 579 57 57,9 824 82 82,4 insulina sexo oxihemoglobina, oxihemoglobina oxi hemoglobina, hemoglobina oxi-hemoglobina mgdL mg dL odds OR [OR 0,96 096 96 [IC 0,920,99 092099 0,92 0,99 92 99 0,92-0,99 (AGV cm 0,98 098 98 0,970,99. 097099 0,97 . 97 0,97-0,99) 0,728 0728 728 0,6200,836 06200836 0,620 0,836 620 836 (0,620-0,836 0,693 0693 693 0,5820,804. 05820804 0,582 0,804 582 804 (0,582-0,804) disso (GH p00 p<0,0 73, 5 57, 8 82, 0,9 09 920 0,920,9 09209 092 099 0,92-0,9 970 0,970,99 09709 097 0,97-0,99 0,72 072 72 6200 0,6200,83 0620083 0620 0,62 0836 0,83 62 83 (0,620-0,83 0,69 069 69 5820 0,5820,804 0582080 0582 0,58 0804 0,80 58 80 (0,582-0,804 p0 p<0, 0, 0,920, 0920 0,92-0, 0,970,9 0970 0,97-0,9 0,7 07 0,6200,8 062008 062 0,6 083 0,8 (0,620-0,8 06 0,5820,80 058208 058 0,5 080 (0,582-0,80 p<0 0,920 0,92-0 0,970, 0,97-0, 0,6200, 06200 08 (0,620-0, 0,5820,8 05820 (0,582-0,8 p< 0,92- 0,970 0,97-0 0,6200 (0,620-0 0,5820, (0,582-0, 0,97- (0,620- 0,5820 (0,582-0 (0,620 (0,582- (0,62 (0,582 (0,6 (0,58 (0, (0,5 (0 (

Abstract Background Systemic arterial hypertension (SAH) is a multifactorial disease, highly prevalent and associated with health risks. Objective The purpose of this study was to investigate the association between SAH and laboratory, anthropometric, heart rate variability (HRV), and obstructive sleep apnea markers and, secondarily, to analyze the sensitivity and specificity of the variables that are independent factors in the association. Methods Cross-sectional study with 95 obese patients treated at an obesity referral clinic in Salvador, BA, Brazil. SAH data were obtained from electronic medical records. The sample was stratified in the Normotensive Group (NG) and the Hypertensive Group (HG), and laboratory markers, body composition, polysomnography, and HRV were measured to evaluate the association of SAH with the predictor variables. For the analysis, p<0.05 was adopted. Results The average age of the NG was 36.3 ± 10.1 and HG 40.4 ± 10.6 years; 73.7% were women in the NG and 57.9% in HG; 82.4% in HG had insulin resistance. In the multivarious logistics regression model with adjustments in age, sex, height, and oxyhemoglobin saturation, SAH was inversely associated with fasting plasma glucose mg/dL (odds ratio [OR] = 0.96; 95% confidence interval [CI] = 0.92-0.99) and visceral fat area (VFA) cm2(OR = 0.98; 95% CI = 0.97-0.99). The area under the VFA curve was 0.728; CI 95% (0.620-0.836); fasting plasma glucose 0.693;CI 95% (0.582-0.804). Conclusions Lower VFA and fasting plasma glucose concentrations were inversely associated with SAH. In addition, fasting plasma glucose and VFA showed a high sensitivity for SAH screening. (SAH disease risks anthropometric HRV, , (HRV) secondarily Crosssectional Cross sectional 9 Salvador BA Brazil records (NG HG, (HG) composition polysomnography analysis p005 p 0 05 p<0.0 adopted 363 36 3 36. 101 10 1 10. 404 40 4 40. 106 6 years 737 73 7 73.7 579 57 57.9 824 82 82.4 resistance sex height saturation mgdL mg dL odds OR [OR 0.96 096 96 [CI 0.920.99 092099 0.92 0.99 92 99 0.92-0.99 (VFA cm2OR cmOR cm2 cm 0.98 098 98 0.970.99. 097099 0.97 . 97 0.97-0.99) 0.728 0728 728 0.6200.836 06200836 0.620 0.836 620 836 (0.620-0.836) 0.693CI 0693CI 0.693 693 0.5820.804. 05820804 0.582 0.804 582 804 (0.582-0.804) addition screening (HRV (HG p00 p<0. 73. 5 57. 8 82. 0.9 09 920 0.920.9 09209 092 099 0.92-0.9 970 0.970.99 09709 097 0.97-0.99 0.72 072 72 6200 0.6200.83 0620083 0620 0.62 0836 0.83 62 83 (0.620-0.836 693CI 0693 0.69 69 5820 0.5820.804 0582080 0582 0.58 0804 0.80 58 80 (0.582-0.804 p0 p<0 0. 0.920. 0920 0.92-0. 0.970.9 0970 0.97-0.9 0.7 07 0.6200.8 062008 062 0.6 083 0.8 (0.620-0.83 069 0.5820.80 058208 058 0.5 080 (0.582-0.80 p< 0.920 0.92-0 0.970. 0.97-0. 0.6200. 06200 06 08 (0.620-0.8 0.5820.8 05820 (0.582-0.8 0.92- 0.970 0.97-0 0.6200 (0.620-0. 0.5820. (0.582-0. 0.97- (0.620-0 0.5820 (0.582-0 (0.620- (0.582- (0.620 (0.582 (0.62 (0.58 (0.6 (0.5 (0. (0 (

https://doi.org/10.36660/abc.20220728

IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M

; Nassar Jr, Antonio Paulo

; Lisboa, Thiago Costa

; Azevedo, Luciano César Pontes de

; Veiga, Viviane Cordeiro

; Catarino, Daniela Ghidetti Mangas

; Fogazzi, Debora Vacaro

; Arns, Beatriz

; Piastrelli, Filipe Teixeira

; Dietrich, Camila

; Negrelli, Karina Leal

; Jesuíno, Isabella de Andrade

; Reis, Luiz Fernando Lima

; Mattos, Renata Rodrigues de

; Pinheiro, Carla Cristina Gomes

; Luz, Mariane Nascimento

; Spadoni, Clayse Carla da Silva

; Moro, Elisângela Emilene

; Bueno, Flávia Regina

; Sampaio, Camila Santana Justo Cintra

; Silva, Débora Patrício

; Baldassare, Franca Pellison

; Silva, Ana Cecilia Alcantara

; Veiga, Thabata

; Barbante, Leticia

; Lambauer, Marianne

; Campos, Viviane Bezerra

; Santos, Elton

; Santos, Renato Hideo Nakawaga

; Laranjeiras, Ligia Nasi

; Valeis, Nanci

; Santucci, Eliana

; Miranda, Tamiris Abait

; Patrocínio, Ana Cristina Lagoeiro do

; Carvalho, Andréa de

; Sousa, Eduvirgens Maria Couto de

; Sousa, Ancelmo Honorato Ferraz de

; Malheiro, Daniel Tavares

; Bezerra, Isabella Lott

; Rodrigues, Mirian Batista

; Malicia, Julliana Chicuta

; Silva, Sabrina Souza da

; Gimenes, Bruna dos Passos

; Sesin, Guilhermo Prates

; Zavascki, Alexandre Prehn

; Sganzerla, Daniel

; Medeiros, Gregory Saraiva

; Santos, Rosa da Rosa Minho dos

; Silva, Fernanda Kelly Romeiro

; Cheno, Maysa Yukari

; Abrahão, Carolinne Ferreira

; Oliveira Junior, Haliton Alves de

; Rocha, Leonardo Lima

; Nunes Neto, Pedro Aniceto

; Pereira, Valéria Chagas

; Paciência, Luis Eduardo Miranda

; Bueno, Elaine Silva

; Caser, Eliana Bernadete

; Ribeiro, Larissa Zuqui

; Fernandes, Caio Cesar Ferreira

; Garcia, Juliana Mazzei

; Silva, Vanildes de Fátima Fernandes

; Santos, Alisson Junior dos

; Machado, Flávia Ribeiro

; Souza, Maria Aparecida de

; Ferronato, Bianca Ramos

; Urbano, Hugo Corrêa de Andrade

; Moreira, Danielle Conceição Aparecida

; Souza-Dantas, Vicente Cés de

; Duarte, Diego Meireles

; Coelho, Juliana

; Figueiredo, Rodrigo Cruvinel

; Foreque, Fernanda

; Romano, Thiago Gomes

; Cubos, Daniel

; Spirale, Vladimir Miguel

; Nogueira, Roberta Schiavon

; Maia, Israel Silva

; Zandonai, Cassio Luis

; Lovato, Wilson José

; Cerantola, Rodrigo Barbosa

; Toledo, Tatiana Gozzi Pancev

; Tomba, Pablo Oscar

; Almeida, Joyce Ramos de

; Sanches, Luciana Coelho

; Pierini, Leticia

; Cunha, Mariana

; Sousa, Michelle Tereza

; Azevedo, Bruna

; Dal-Pizzol, Felipe

; Damasio, Danusa de Castro

; Bainy, Marina Peres

; Beduhn, Dagoberta Alves Vieira

; Jatobá, Joana D’Arc Vila Nova

; Moura, Maria Tereza Farias de

; Rego, Leila Rezegue de Moraes

; Silva, Adria Vanessa da

; Oliveira, Luana Pontes

; Sodré Filho, Eliene Sá

; Santos, Silvana Soares dos

; Neves, Itallo de Lima

; Leão, Vanessa Cristina de Aquino

; Paes, João Lucidio Lobato

; Silva, Marielle Cristina Mendes

; Oliveira, Cláudio Dornas de

; Santiago, Raquel Caldeira Brant

; Paranhos, Jorge Luiz da Rocha

; Wiermann, Iany Grinezia da Silva

; Pedroso, Durval Ferreira Fonseca

; Sawada, Priscilla Yoshiko

; Prestes, Rejane Martins

; Nascimento, Glícia Cardoso

; Grion, Cintia Magalhães Carvalho

; Carrilho, Claudia Maria Dantas de Maio

; Dantas, Roberta Lacerda Almeida de Miranda

; Silva, Eliane Pereira

; Silva, Antônio Carlos da

; Oliveira, Sheila Mara Bezerra de

; Golin, Nicole Alberti

; Tregnago, Rogerio

; Lima, Valéria Paes

; Silva, Kamilla Grasielle Nunes da

; Boschi, Emerson

; Buffon, Viviane

; Machado, André Sant’Ana

; Capeletti, Leticia

; Foernges, Rafael Botelho

; Carvalho, Andréia Schubert de

; Oliveira Junior, Lúcio Couto de

; Oliveira, Daniela Cunha de

; Silva, Everton Macêdo

; Ribeiro, Julival

; Pereira, Francielle Constantino

; Salgado, Fernanda Borges

; Deutschendorf, Caroline

; Silva, Cristofer Farias da

; Gobatto, Andre Luiz Nunes

; Oliveira, Carolaine Bomfim de

; Dracoulakis, Marianna Deway Andrade

; Alvaia, Natália Oliveira Santos

; Souza, Roberta Machado de

; Araújo, Larissa Liz Cardoso de

; Melo, Rodrigo Morel Vieira de

; Passos, Luiz Carlos Santana

; Vidal, Claudia Fernanda de Lacerda

; Rodrigues, Fernanda Lopes de Albuquerque

; Kurtz, Pedro

; Shinotsuka, Cássia Righy

; Tavares, Maria Brandão

; Santana, Igor das Virgens

; Gavinho, Luciana Macedo da Silva

; Nascimento, Alaís Brito

; Pereira, Adriano J

; Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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dec 2022, Volume 34 N. 4 Pages 418 - 425

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.

ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,

https://doi.org/10.5935/0103-507x.20220209-pt

Molecular aspects of COVID-19 and its relationship with obesity and physical activity: a narrative review
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Lino, Ramon de Souza

; Silva, Mariana Sousa de Pina

; Jesus, Daniel Simões de

; Macedo, Rodrigo Colares de

; Lagares, Laura Souza

; Santos, Felipe Nunes Almeida dos

; Almeida, Luiz Alberto Bastos de

; Bomfim, Eric Simas

; Santos, Clarcson Plácido Conceição dos

Sao Paulo Medical Journal

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2022, N. ahead

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1516-3180.2021.1038.r1.06072022

Análise crítica dos indicadores do estado nutricional de iodo em indivíduos e populações: uma revisão sistemática
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Candido, Aline Carare

; Azevedo, Francilene Maria

; Macedo, Mariana de Souza

; Priore, Silvia Eloiza

; Franceschini, Sylvia do Carmo Castro

Ciência & Saúde Coletiva

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oct 2021, Volume 26 Suppl. 3 Pages 4859 - 4870

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste artigo é avaliar as potencialidades dos indicadores do estado nutricional de iodo em indivíduos ou populações. A revisão foi baseada no PRISMA. A busca pelos artigos ocorreu em janeiro de 2019, nas bases Pubmed, Scopus e LILACS, utilizando a combinação “indicadores AND estado nutricional AND iodo”. A seleção seguiu as etapas de exclusão dos duplicados, leitura de títulos e resumos e análise na íntegra. A qualidade metodológica dos estudos foi avaliada pelo instrumento de Downs e Black. Foram identificados 178 estudos e 20 foram incluídos. A Concentração Urinária de Iodo (CUI) foi analisada em 65% dos estudos e foi considerado o melhor indicador para avaliar o estado nutricional de iodo populacional. A tiroglobulina foi determinada em 20% dos estudos e refletiu o estado de iodo pregresso. O hormônio estimulante da tireoide foi verificado em 45% dos artigos e mostrou-se sensível para a vigilância de deficiência de iodo em recém-nascidos. Apenas um estudo avaliou o iodo no cabelo, útil para analisar a ingestão dietética em longo prazo. Na avaliação da qualidade metodológica, a menor pontuação foi 12, e a maior 16, em 17 pontos possíveis. Para diagnóstico de deficiência e excesso de iodo na população, recomenda-se a CUI.

Abstract The scope of this article is to evaluate the potentialities of indicators of the nutritional status of iodine in individuals or populations. The review was based on PRISMA. The search for articles occurred in January 2019, in the Pubmed, Scopus and LILACS databases, using the key words: indicators AND nutritional status AND iodine. The selection followed the stages of excluding the duplicates, reading the titles, abstracts and analyses in full. The methodological quality of the studies was evaluated by the Downs and Black instrument. A total of 178 studies were identified and 20 were included. Urinary Iodine Concentration (UIC) was analyzed in 65% of the studies and was considered the best indicator to evaluate the nutritional status of iodine in the population. Thyroglobulin was determined in 20% of the studies and reflected the pre-existing state of iodine. Thyroid stimulating hormone was verified in 45% of the articles and was important for the surveillance of iodine deficiency among newborns. Only one study evaluated capillary iodine, useful for analyzing long-term dietary intake. In the evaluation of methodological quality, the lowest score was 12 and the highest 16, in 17 possible points. The use of UIC is recommended for the diagnosis of deficiency and excess of iodine in the population.

https://doi.org/10.1590/1413-812320212611.3.16772019 1 downloads

10.

Análise crítica dos indicadores do estado nutricional de iodo em indivíduos e populações: uma revisão sistemática
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Candido, Aline Carare

; Azevedo, Francilene Maria

; Macedo, Mariana de Souza

; Priore, Silvia Eloiza

; Franceschini, Sylvia do Carmo Castro

Ciência & Saúde Coletiva

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oct 2021, Volume 26 Suppl. 3 Pages 4859 - 4870

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-812320212611.3.16772019

11.

[SciELO Preprints] - COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas during the pandemic first wave: study protocol and initial results
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Meireles, Adriana Lucia Lourenção, Luciano Garcia Menezes Junior, Luiz Antônio Alves de Coletro, Hillary Nascimento Justiniano, Irene Carolina Sousa Moura, Samara Silva de Diniz, Amanda Popolino Sabião, Thaís da Silva Rocha, Ana Maria Sampaio Batista, Aline Priscila Lage, Nara Nunes Simões, Bárbara dos Santos Santos, Carolina Ali Mendonça, Raquel de Deus Andrade, Amanda Cristina de Souza Barbosa, Keila Furbino Masioli, Cássio Zumerle Carraro, Júlia Cristina Cardoso Menezes, Mariana Carvalho de Nascimento, Renata Cristina Rezende Macedo Roever, Leonardo Caiaffa, Waleska Teixeira Machado-Coelho, George Luiz Lins

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Publication date: 2021-07-29

Abstract: En

Background: A population study is an important tool that can be used to understand the actual epidemiological scenario of the Covid-19 in different territories, identify its magnitude, understand its transmission dynamics, and its demographic, geographical, and social distribution. Objective: The aim of this study was to determine the prevalence and dynamics of SARS-CoV-2 infection in the population of two Brazilian cities during the pandemic first wave and subsequent socioeconomic and health effects. Materials & methods: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to-face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4%) were in Mariana and 998 (56.6%) in Ouro Preto. For both cities, 51.9% of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2%). The prevalence of the SARS-CoV-2 infection was 5.5% in all cities, 6.2% in Ouro Preto, and 4.7% in Mariana. The prevalence was similar between cities (P>0.05). Conclusion: The study was effective in verifying the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.

https://doi.org/10.1590/SciELOPreprints.2720

12.

Fatores associados ao estado nutricional de iodo no grupo materno-infantil: uma revisão sistemática
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Candido, Aline Carare

; Priore, Silvia Eloíza

; Macedo, Mariana de Souza

; Franceschini, Sylvia do Carmo Castro

Ciência & Saúde Coletiva

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apr 2021, Volume 26 N. 4 Pages 1381 - 1390

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste artigo é identificar os fatores sociodemográficos e alimentares associados ao estado nutricional de iodo do grupo materno-infantil. A revisão foi baseada no método PRISMA. As bases consultadas foram: Medline (PubMed), Scopus e Lilacs. A busca ocorreu em dezembro de 2018, utilizando os descritores estado nutricional, iodo, lactente, gestante e lactante. A seleção seguiu as etapas de exclusão dos duplicados, leitura dos títulos, resumos e análise na íntegra. Foram identificados 1.500 estudos e 26 contemplaram os critérios de inclusão. A qualidade metodológica dos estudos foi avaliada pelo questionário proposto por Downs e Black. Houve associação entre os fatores sociodemográficos renda, escolaridade, idade materna e gestacional, paridade e local de residência rural ou urbano com o estado nutricional de iodo. Já em relação aos fatores alimentares, o consumo de suplementos, sal iodado e alimentos fontes de iodo, em especial os produtos lácteos, exercem papel protetor contra a deficiência. É preciso criar estratégias mais específicas, efetivas e que contemplem todos esses fatores que afetam o estado nutricional de iodo para evitar as desordens provocadas pela deficiência.

Abstract This article sets out to identify the socio-demographic and nutritional factors associated with the nutritional status of iodine in the maternal-infant group. The review was based on the Prisma method and the Medline (PubMed), Scopus and Lilacs databases were consulted. The search was conducted in December 2018, using the key words nutritional status, iodine, infant, pregnant and lactating. The selection followed the stages of excluding duplicated articles, reading the titles, abstracts and texts in full. A total of 1,500 studies were identified and 26 met the inclusion criteria. The methodological quality of the studies was evaluated using the questionnaire proposed by Downs and Black. There was an association between the sociodemographic factors of income, education, maternal and gestational age, uniformity and place of residence in rural or urban areas with the nutritional state of iodine. In relation to dietary factors, the consumption of supplements, iodized salt and dietary sources of iodine, especially dairy products, play a protective role to avoid the deficiency. It is necessary to create more specific and effective strategies that address all the factors that affect the nutritional state of iodine to avoid the disorders resulting from the deficiency.

https://doi.org/10.1590/1413-81232021264.13482019 563 downloads

13.

RELATIONSHIP BETWEEN THE DIET QUALITY INDEX IN NURSING MOTHERS AND THE FATTY ACID PROFILE OF MATURE BREAST MILK
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Freitas, Ronilson Ferreira

; Macedo, Mariana de Souza

; Lessa, Angelina do Carmo

; Pinto, Nísia Andrade Villela Dessimoni

; Teixeira, Romero Alves

Revista Paulista de Pediatria

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2021, Volume 39 elocation e2019089

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a relação entre a qualidade da dieta materna e a composição do leite humano em ácidos graxos no primeiro trimestre de lactação. Métodos: Trata-se de um estudo epidemiológico observacional e transversal com nutrizes. Os instrumentos de coleta dos dados foram questionário semiestruturado para caracterização da amostra e o recordatório de ingestão habitual. A qualidade da dieta foi avaliada por meio do índice de alimentação saudável (IAS). Amostras de leite materno maduro foram obtidas por meio de ordenha manual. A extração da gordura do leite ocorreu mediante o método de Bligh-Dyer, e essa gordura foi metilada com metóxido de sódio 0,25 mol/L em metanol dietil éter. O perfil de ácidos graxos do leite foi determinado por um cromatógrafo a gás equipado com detector por ionização de chamas. Realizaram-se teste de correlação de Pearson e teste de Spearman para verificar associação entre as variáveis. Posteriormente se aplicaram o modelo de regressão linear múltiplo e a análise de regressão multivariada. Resultados: Foi possível observar relação inversa entre o consumo de frutas totais e o perfil de ácidos graxos poli-insaturados e relação direta entre o consumo de frutas totais e cereais totais e os ácidos monoinsaturados e saturados. Conclusões: Sugere-se que a qualidade da dieta reflete na composição de ácidos graxos do leite materno.

ABSTRACT Objective: To evaluate the relationship between the maternal diet quality and the fatty acid composition of breast milk in the first trimester of lactation. Methods: This is an observational cross-sectional epidemiological study of nursing mothers. The data collection instruments were a semi-structured questionnaire for sample characterization and a recall of usual intake. Diet quality was assessed based on the healthy eating index (HEI). Samples of mature breast milk were obtained by hand milking. Milk fat was extracted using the Bligh-Dyer method and methylated with 0.25 mol/L sodium methoxide in methanol diethyl ether. A gas chromatograph equipped with a flame ionization detector determined the milk fatty acid profile. Pearson’s and Spearman’s correlation tests evaluated association between the variables. Subsequently, a multiple linear regression model was built and multivariate regression analysis was applied. Results: Our findings revealed an inverse relationship between the consumption of total fruits and the polyunsaturated fatty acid profile and a direct association of the intake of total fruits and total grains with monounsaturated and saturated fatty acids. Conclusions: The results of this study suggest that maternal diet quality affects the fatty acid composition of breast milk.

https://doi.org/10.1590/1984-0462/2021/39/2019089 2683 downloads

14.

Brazilian Theraphosidae: a toxicological point of view
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Macedo, Keven Wender Rodrigues

; Costa, Lucas Jeferson de Lima

; Souza, Jéssica Oliveira de

; Vasconcelos, Isadora Alves de

; Castro, Jessica Schneider de

; Santana, Carlos José Correia de

; Magalhães, Ana Carolina Martins

; Castro, Mariana de Souza

; Pires Júnior, Osmindo Rodrigues

Journal of Venomous Animals and Toxins including Tropical Diseases

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2021, Volume 27 elocation e20210004

Abstract: En | Text: En | PDF: En

Abstract The Theraphosidae family includes the largest number of species of the Mygalomorphae infraorder, with hundreds of species currently catalogued. However, there is a huge lack on physiologic and even ecologic information available, especially in Brazil, which is the most biodiverse country in the world. Over the years, spiders have been presented as a source of multiple biologically active compounds with basic roles, such as primary defense against pathogenic microorganisms or modulation of metabolic pathways and as specialized hunters. Spider venoms also evolved in order to enable the capture of prey by interaction with a diversity of molecular targets of interest, raising their pharmaceutical potential for the development of new drugs. Among the activities found in compounds isolated from venoms and hemocytes of Brazilian Theraphosidae there are antimicrobial, antifungal, antiparasitic and antitumoral, as well as properties related to proteinase action and neuromuscular blockage modulated by ionic voltage-gated channel interaction. These characteristics are present in different species from multiple genera, which is strong evidence of the important role in spider survival. The present review aims to compile the main results of studies from the last decades on Brazilian Theraphosidae with special focus on results obtained with the crude venom or compounds isolated from both venom and hemocytes, and their physiological and chemical characterization.

https://doi.org/10.1590/1678-9199-jvatitd-2021-0004

15.

Fatores associados ao estado nutricional de iodo no grupo materno-infantil: uma revisão sistemática
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Candido, Aline Carare

; Priore, Silvia Eloíza

; Macedo, Mariana de Souza

; Franceschini, Sylvia do Carmo Castro

Ciência & Saúde Coletiva

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2021, Volume 26 N. 4 Pages 1381 - 1390

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021264.13482019

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