RESUMO A solução fundamental para o problema do entupimento do emissor é explorar o projeto ideal da estrutura do emissor e melhorar sua capacidade anti-entupimento. O objetivo da pesquisa foi selecionar a forma estrutural ideal do caminho de fluxo do emissor em sistemas de irrigação por gotejamento utilizando fontes de água de qualidade inferior, proporcionando suporte teórico para melhorar a capacidade anti-obstrução do próprio emissor e para o projeto de novos produtos de emissores. A seleção da estrutura do caminho do fluxo do emissor não tem sido conduzida com base na determinação do modelo de simulação apropriado com a condição complexa de qualidade da água. Para tanto, determinou-se o modelo de movimento interno do fluido adequado do emissor, e avaliou-se de forma abrangente o desempenho hidráulico e o desempenho anti-entupimento das cinco estruturas representativas da trajetória de fluxo no país e no exterior, e finalmente determinou-se a estrutura ótima da trajetória de fluxo do emissor. Os resultados da pesquisa indicaram que o modelo RNG k-ε foi o mais adequado para simular a área do fluxo no emissor por meio da análise abrangente da lacuna entre os valores simulados e os valores medidos, da precisão do cálculo e da eficiência computacional. A trajetória de fluxo fractal foi relativamente ótima para o desempenho hidráulico e para o desempenho anti-entupimento. Este estudo pode fornecer suporte teórico para melhorar a própria habilidade anti-obstrução do emissor e o projeto de novo produto de emissor. antientupimento. antientupimento anti entupimento. inferior antiobstrução obstrução emissores tanto determinouse determinou se avaliouse avaliou exterior kε k ε medidos computacional

ABSTRACT The fundamental solution to the problem of emitter clogging is to explore the optimal structure design of emitter and improve its anti-clogging ability. The research objective was to select the optimal structural form of the emitter flow path in drip irrigation systems using inferior water sources, which can provide theoretical support for improving the anti-clogging ability of the emitter itself and designing new emitter products. The selection of the flow path structure of the emitter has not been conducted on the basis of determining the appropriate simulation model with the condition of complex water quality. Therefore, the appropriate internal fluid movement model of the emitter was determined, the hydraulic performance and anti-clogging performance of the five nationally and internationally representative flow path structures were comprehensively evaluated, and finally the optimal structure of the emitter flow path was determined. The research results indicated that RNG k - ε model was the most suitable to simulate the flow field in the emitter by comprehensive analysis of the gap between simulated values and the measured values, the calculation accuracy and computational efficiency. The fractal flow path was relatively optimal for hydraulic performance and for anti-clogging performance. This study can provide theoretical support for improving the anti-clogging ability of the emitter itself and the design of the new emitter product. anticlogging anti sources products quality Therefore determined evaluated efficiency product

RESUMO: Com base nos dados do investimento da China em terras aráveis no exterior em 47 países ao longo do “Cinturão e Rota”, o modelo Tobit é utilizado para analisar os efeitos da distância cultural e das cidades amigas nas taxas de produção de terras aráveis contratadas no investimento da China em terras aráveis no exterior. Os resultados mostram que as diferenças na distância cultural, na distância de poder e no grau de prevenção de incertezas têm efeitos positivos significativos sobre as taxas de produção de terras aráveis contratadas no investimento em terras aráveis no exterior da China, e as diferenças no individualismo têm um efeito negativo significativo sobre as taxas de produção. As cidades amigas têm um efeito positivo, mas insignificante, sobre as taxas de produção, enquanto estas podem enfraquecer o impacto positivo da distância cultural sobre as taxas de produção de terras aráveis contratadas no investimento em terras aráveis no exterior da China. A proporção de investimento cooperativo entre a China e o país anfitrião, o nível econômico e o ambiente institucional do país anfitrião terão um impacto sobre as taxas de produção. Por fim, são propostas recomendações para promover as taxas de produção das terras aráveis contratadas, tais como a concentração no papel positivo da distância cultural, a criação de cidades da amizade e o investimento em países de acolhimento com elevado potencial. RESUMO 4 Cinturão Rota, Rota , Rota” insignificante fim potencial

ABSTRACT: Based on the data of China’s overseas arable land investment in 47 countries along the “Belt and Road”, the Tobit model is used to analyze the effects of cultural distance and friendship cities on the production rates of contracted arable land in China’s overseas arable land investment. This study provided theoretical basis and empirical support for promoting China’s agricultural “going abroad” and improving the production rates of contracted arable land in China’s overseas arable land investment. The results show that differences in cultural distance, power distance and the degree of uncertainty avoidance have significant positive effects on the production rates of contracted arable land in China’s overseas arable land investment, and differences in individualism have a significant negative effect on the production rates. Friendship city has a positive but insignificant effect on the production rates, meanwhile, it also weaken the positive impact of cultural distance on production rates of contracted arable land in China’s overseas arable land investment. The proportion of joint ventures with host country, the economic level and institutional environment of the host country will all have an impact on the production rates. Finally, recommendations are proposed to promote the production rates of contracted arable land, such as focusing on the positive role of cultural distance, establishing friendship cities, and investing host countries with high potential precisely. ABSTRACT Chinas China s 4 Belt Road, Road , Road” going abroad meanwhile Finally precisely

BiOCl/KBiO3 p-n heterostructures with hierarchical mesoporous architectures were successfully synthesized via a facile in situ method. The X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and scanning electron microscope (SEM) results indicate the formation of heterojunctions between BiOCl and KBiO3. The photocatalytic performance of the as-prepared samples was investigated by the degradation of dye Rhodamine B (RhB) under visible light irradiation. BiOCl/KBiO3 composite has never been used to photodegrade the RhB which is a common dye and very difficult to degrade. The results demonstrated that KBiO3 combined with proper amount of BiOCl nanosheets exhibited high efficiency in the photocatalytic process, and BiOCl/KBiO3 with the molar ratio of 70/30 demonstrated the highest photocatalytic activity due to its large surface area, excellent charge separation characteristics and the suppressed recombination of electron-hole pairs. The results of active species detection reveal that the superoxide radical anions (O2-), hydroxyl free radicals (·OH), photogenerated holes (h+) and photogenerated electrons (e-) reactive species work together for the photocatalytic degradation of RhB. A possible and new mechanism of photocatalysis that differs from other teams was also explored and proposed. The present study will benefit the development of the new p-n heterojunction photocatalysts and would be of great importance to meet ever-increasing environmental demands in the future. BiOClKBiO3 BiOClKBiO KBiO BiOCl/KBiO pn p n method Xray X ray XRD, XRD , (XRD) XPS (XPS SEM (SEM asprepared as prepared (RhB irradiation degrade process 7030 70 30 70/3 area electronhole hole pairs O2, O2 O (O2-) ·OH, OH ·OH (·OH) h+ h (h+ e (e- proposed everincreasing ever increasing future (XRD 703 7 3 70/ (O2- (·OH (h (e (O2 (O

Abstract The mental health for workers in healthcare was affected by the overload derived from care for COVID-19 patients. It is recognized that there was no knowledge about the disease or labor systems prepared to deal with the pandemic. Mental health problems among of a group of eight nursing workers (6 women and 2 men) employed at a state health institution was addressed through a mutual help group created as an emotional support network. The information co-created by the group across 10 sessions was analyzed through narratives using a relativistic approach, with the thematic axes of emotional discomfort in the face of uncertainties and aggressions; need to be and moral dilemmas; courage to overcome institutional disorganization; emotional overload and the recovery of strategies and resources. The implications of the process narrated by the group resulted in an effective strategy for improving the mental health of the participants and the need to have virtual services to cope with needs or circumstances such as those triggered by a pandemic as well as the strength of the group process are discussed.

Resumen La salud mental del personal sanitario quedó afectada ante la sobrecarga derivada de la atención a pacientes por COVID-19. Se entiende que no había conocimientos sobre la enfermedad ni sistemas laborales preparados para atender la pandemia. La problemática de salud mental de un grupo de 8 profesionales de enfermería (6 mujeres y 2 hombres), laborando en una institución de salud estatal, fue atendida a través de un grupo de ayuda mutua creado como dispositivo de contención emocional. Se analiza la información co-creada por el proceso grupal de 10 sesiones a través de las narrativas desde un enfoque relativista, con los ejes temáticos del malestar emocional ante las incertidumbres y las agresiones; el deber ser y las disyuntivas morales; el coraje impulsor ante la desorganización institucional, la sobrecarga emocional y la recuperación de estrategias y recursos. Se discuten las implicaciones del proceso narrado por el grupo constituido como una estrategia efectiva para la mejora en la salud mental de los participantes y la necesidad de tener dispositivos virtuales ante necesidades o circunstancias como las detonadas por una pandemia, así como la fortaleza del proceso grupal.

Resumen Introducción. La contaminación por metales pesados es un problema que ha ido en aumento, debido a las actividades antrópicas. Las plantas pueden eliminar, destruir o transformar contaminantes del suelo, agua y aire. Con el empleo de reguladores del crecimiento vegetal y agentes quelantes se puede reducir la toxicidad por metales pesados. Objetivo. Evaluar el efecto de la aplicación de una mezcla de oligogalacturónidos sobre la actividad peroxidasa y los contenidos de malondialdehido, proteinas totales y clorofilas, en plantas de tomate (Solanum lycopersicum L.) var. Amalia sometidas a altos niveles de metales pesados. Materiales y métodos. Se colectó suelo contaminado con Cu, Cd y el Fe, en la Empresa cerámica blanca Adalberto Vidal de Mayabeque, Cuba en el año 2020. El experimento se desarrolló en bolsas de 7 kg de capacidad y se utilizaron plantas de tomate, en condiciones semi controladas en áreas del Instituto Nacional de Ciencias Agrícolas (INCA), con un diseño experimental completamente aleatorizado con siete tratamientos y diez réplicas. Los tratamientos del producto a base de oligogalacturónidos (Ogal) fueron: aplicación al suelo (30 mg kg-1); aspersión foliar (20 mg L-1), la combinación de estas formas de aplicación y un testigo. A los 35 y 56 días de emergidas las plantas, se determinó la actividad peroxidasa y los contenidos de malondialdehido, proteinas totales y clorofilas. Resultados. El efecto que provocan el Cu, Cd y el Fe en las plántulas, fue atenuado por todas las variantes de uso de la mezcla Ogal, por lo que las mismas han desarrollado mecanismos de adaptación ante las altas concentraciones metálicas que le permiten subsistir al estrés abiótico. Conclusiones. La mezcla de Ogal atenuó el efecto que provocan los metales pesados en la actividad peroxidasa, el contenido malondialdehido, proteínas totales y clorofilas en plantas de tomate var. Amalia.

Abstract Introduction. Heavy metal pollution is a growing problem due to human activities. Plants can remove, destroy, or transform contaminants from soil, water, and air. By using plant growth regulators and chelating agents, heavy metal toxicity can be reduced. Objective. To evaluate the effect of applying a mixture of oligogalacturonides on peroxidase activity and the contents of malondialdehyde, total protein, and chlorophylls in tomato plants (Solanum lycopersicum L.) var. Amalia subjected to high levels of heavy metals. Materials and methods. Soil contaminated with Cu, Cd, and Fe was collected from the Adalberto Vidal White Ceramic Company in Mayabeque, Cuba, in 2020. The experiment was conducted in 7 kg capacity bags using tomato plants, under semi-controlled conditions at the Instituto Nacional de Ciencias Agrícolas (INCA), with a completely randomized experimental design with each treatment having ten replicates. The treatments with the oligogalacturonides (Ogal) were soil application (30 mg kg-1); foliar spray (20 mg L-1), the combination of these application forms, and a control. Peroxidase activity and the contents of malondialdehyde, total protein, and chlorophylls were determined at 35 and 56 days after the plant’s emergence. Results. The effect of Cu, Cd, and Fe on the seedlings was attenuated by all the use of the Ogal mixture variants use, indicating that they have developed adaptation mechanisms to high metal concentrations which allows to withstand abiotic stress. Conclusions. The Ogal mixture attenuated the effect of heavy metals on peroxidase activity, malondialdehyde content, total proteins, and chlorophylls in Amalia tomato plants.

ABSTRACT Introduction: We aim to compare the safety and effectiveness of the KangDuo (KD)-Surgical Robot-01 (KD-SR-01) system and the da Vinci (DV) system for robot-assisted radical nephroureterectomy (RARNU). Materials and Methods: This multicenter prospective randomized controlled trial was conducted between March 2022 and September 2023. Group 1 included 29 patients undergoing KD-RARNU. Group 2 included 29 patients undergoing DV-RARNU. Patient demographic and clinical characteristics, perioperative data, and follow-up outcomes were collected prospectively and compared between the two groups. Results: There were no significant differences in patient baseline demographic and preoperative characteristics between the two groups. The success rates in both groups were 100% without conversion to open or laparoscopic surgery or positive surgical margins. No significant difference was observed in docking time [242 (120-951) s vs 253 (62-498) s, P = 0.780], console time [137 (55-290) min vs 105 (62-220) min, P = 0.114], operative time [207 (121-460) min vs 185 (96-305) min, P = 0.091], EBL [50 (10-600) mL vs 50 (10-700) mL, P = 0.507], National Aeronautics and Space Administration Task Load Index scores, and postoperative serum creatinine levels between the two groups. None of the patients showed evidence of distant metastasis, local recurrence, or equipment-related adverse events during the four-week follow-up. One (3.4%) patient in Group 2 experienced postoperative enterovaginal and enterovesical fistulas (Clavien-Dindo grade III). Conclusions: The KD-SR-01 system is safe and effective for RARNU compared to the DV Si or Xi system. Further randomized controlled studies with larger sample sizes and longer durations are required. Introduction KDSurgical KD Surgical Robot01 Robot 01 Robot-0 KDSR01 KDSR SR (KD-SR-01 (DV robotassisted robot assisted RARNU. . (RARNU) Methods 202 2023 KDRARNU. KDRARNU KD-RARNU DVRARNU. DVRARNU DV-RARNU data followup follow up Results 100 margins 242 [24 120951 120 951 (120-951 25 62498 62 498 (62-498 0.780, 0780 0.780 , 0 780 0.780] 137 [13 55290 55 290 (55-290 10 62220 220 (62-220 0.114, 0114 0.114 114 0.114] 207 [20 121460 121 460 (121-460 18 96305 96 305 (96-305 0.091, 0091 0.091 091 0.091] [5 10600 600 (10-600 5 10700 700 (10-700 0.507, 0507 0.507 507 0.507] scores metastasis recurrence equipmentrelated equipment related fourweek four week followup. up. 3.4% 34 3 4 (3.4% ClavienDindo Clavien Dindo III. III III) Conclusions KD-SR-0 required Robot0 Robot- KDSR0 (KD-SR-0 (RARNU 20 24 [2 12095 12 95 (120-95 6249 6 49 (62-49 078 0.78 78 13 [1 5529 (55-29 6222 22 (62-22 011 0.11 11 12146 46 (121-46 9630 9 30 (96-30 009 0.09 09 [ 1060 60 (10-60 1070 70 (10-70 050 0.50 3.4 (3.4 KD-SR- (KD-SR- 1209 (120-9 624 (62-4 07 0.7 7 552 (55-2 622 (62-2 0.1 1214 (121-4 963 (96-3 00 0.0 106 (10-6 107 (10-7 05 0.5 3. (3. KD-SR (KD-SR (120- (62- 0. (55- (121- (96- (10- (3 (120 (62 (55 (121 (96 (10 ( (12 (6 (5 (9 (1

Abstract Objective To assess the outcome of patients with cancer-related sepsis requiring continuous renal replacement therapy (CRRT) in a single-center pediatric intensive care unit (PICU). Method Children with sepsis who necessitate CRRT from January 2017 to December 2021 were enrolled. The patients with leukemia/lymphoma or solid tumors were defined as underlying cancer. Multivariate logistic regression analysis was performed to identify the death risk factors in patients with cancer-related sepsis. Results A total of 146 patients were qualified for inclusion. Forty-six (31.5%) patients with cancer-related sepsis and 100 (68.5%) non-cancer-related sepsis. The overall PICU mortality was 28.1% (41/146), and mortality was significantly higher in cancer-related sepsis patients compared with non-cancer patients (41.3% vs. 22.0%, p = 0.016). Need mechanical ventilation, p-SOFA, acute liver failure, higher fluid overload at CRRT initiation, hypoalbuminemia, and high inotropic support were associated with PICU mortality in cancer-related sepsis patients. Moreover, levels of IL-6, total bilirubin, creatinine, blood urea nitrogen, and international normalized ratio were significantly higher in non-survivors than survivors. In multivariate logistic regression analysis, pediatric sequential organ failure assessment (p-SOFA) score (OR:1.805 [95%CI: 1.047-3.113]) and serum albumin level (OR: 0.758 [95%CI: 0.581 -0.988]) were death risk factors in cancer-related sepsis receiving CRRT, and the AUC of combined index of p-SOFA and albumin was 0.852 (95% CI: 0.730-0.974). Conclusion The overall PICU mortality is high in cancer-related sepsis necessitating CRRT. Higher p-SOFA and lower albumin were independent risk factors for PICU mortality. cancerrelated cancer related (CRRT singlecenter single center PICU. . (PICU) 201 202 enrolled leukemialymphoma leukemia lymphoma 14 inclusion Fortysix Forty six 31.5% 315 31 5 (31.5% 10 68.5% 685 68 (68.5% noncancerrelated non 281 28 1 28.1 41/146, 41146 41/146 , 41 (41/146) noncancer 41.3% 413 3 (41.3 vs 220 22 0 22.0% 0.016. 0016 0.016 016 0.016) ventilation pSOFA, pSOFA SOFA, SOFA initiation hypoalbuminemia Moreover IL6, IL6 IL 6, 6 IL-6 bilirubin creatinine nitrogen nonsurvivors survivors (p-SOFA OR1.805 OR1805 OR 1.805 805 (OR:1.80 95%CI 95CI CI 95 [95%CI 1.0473.113 10473113 1.047 3.113 047 113 1.047-3.113] (OR 0758 758 0.75 0581 581 0.58 0.988 0988 988 -0.988] 0852 852 0.85 95% (95 0.7300.974. 07300974 0.730 0.974 730 974 0.730-0.974) (PICU 20 31.5 (31.5 68.5 (68.5 2 28. 4114 41/14 4 (41/146 41.3 (41. 22.0 001 0.01 01 IL- OR1 OR1.80 OR180 1805 1.80 80 (OR:1.8 9 0473 1.0473.11 1047311 1047 1.04 3113 3.11 04 11 1.047-3.113 075 75 0.7 058 58 0.5 0.98 098 98 -0.988 085 85 0.8 (9 7300 0.7300.974 0730097 0730 0.73 0974 0.97 73 97 0.730-0.974 31. (31. 68. (68. 411 41/1 (41/14 41. (41 22. 00 0.0 OR1.8 OR18 180 1.8 8 (OR:1. 1.0473.1 104731 104 1.0 311 3.1 1.047-3.11 07 7 0. 05 0.9 09 -0.98 08 ( 0.7300.97 073009 073 097 0.730-0.97 (31 (68 41/ (41/1 (4 OR1. 18 1. (OR:1 1.0473. 10473 3. 1.047-3.1 -0.9 0.7300.9 07300 0.730-0.9 (3 (6 (41/ 1.0473 1.047-3. -0. 0.7300. 0.730-0. 1.047-3 -0 0.7300 0.730-0 1.047- - 0.730-

ABSTRACT Cercospora leaf spot (CLS) disease and bruchids are the common disease and insect pest causing yield loss in mung bean (Vigna radiata (L.) R. Wilczek). ‘KUML4’ is an improved mung bean cultivar grown in Thailand having high yield, early and highly synchronous maturity, large seed size, but susceptible to CLS disease and bruchids. This study was conducted to improve ‘KUML4’ through introgression of VrTAF5 for CLS resistance and VrPGIP2 for bruchid (Callosobruchus maculatus) resistance from landrace mung bean accessions ‘V4718’ and ‘V2808’, respectively, by marker-assisted backcrossing (MABC). In the MABC, foreground selections were performed using VrTAF5- and VrPGIP2-specific markers. The BC3F3 pyramided lines with KUML4 background carrying both VrTAF5 and VrPGIP2 genes were developed and evaluated for agronomic and yield-related traits, CLS resistance, and bruchid resistance. Three BC3F3 lines, KUML4-2020-21, KUML4-2020-23, and KUML4-2020-60, exhibiting superior agronomic and yield-related traits, CLS resistance, and bruchid resistance than ‘KUML4’ were successfully obtained via MABC. Under the CLS outbreak, these lines showed 248.5%-331.7% higher seed yield than ‘KUML4’. The lines expressed nearly perfect resistance to bruchid (< 5% seeds damaged). These lines can be developed into new resistant mung bean cultivars in the future.

Abstract Introduction: The combination of norethisterone enanthate (50mg), estradiol valerate (5mg) (Mesigyna®) is a contraceptive with extensive real-life use. However, the use of contraceptives in Peru is below the regional average. Objective: Evaluate the safety profile of the combination of norethisterone enanthate (50 mg), estradiol valerate (5 mg) (Mesigyna®), as a contraceptive method in clinical practice in Peru. Method: A prospective, observational, longitudinal study was conducted in women of childbearing age treated with Mesigyna®. Sociodemographic, drug, follow-up and safety variables were collected. Qualitative variables are reported in frequencies, and adverse events in incidence rates. Results: A total of 237 patients were eligible for the safety profile analysis, with a mean age of 26.5 ± 5.9 years. No pregnancies were reported. 32.9% (n = 78) of patients had 213 adverse events (95% CI: 26.97-39.29%), with an incidence of 285.7 per 100 person-years (95% CI: 248.8-326.6). The incidence of serious adverse events was 4.0 per 100 person-years (95% CI: 0.8-11.7). Conclusions: Mesigyna® is a contraceptive method with a favorable safety profile, according with the results observed in clinical studies of the molecule and in the literature.

Resumen Introducción: La combinación de enantato de noretisterona (50mg) y valerato de estradiol (5mg) (Mesigyna®), es un anticonceptivo con amplio uso en vida real. Sin embargo, el uso de anticonceptivos en Perú esta por debajo de la media regional. Objetivo: Evaluar el perfil de seguridad de la combinación de enantato de noretisterona (50 mg), valerato de estradiol (5 mg) (Mesigyna®) como método anticonceptivo en la práctica clínica en Perú. Método: Se realizó un estudio prospectivo, observacional, longitudinal, en mujeres en edad fértil tratadas con Mesigyna®. Se recolectaron variables sociodemográficas, del medicamento, de seguimiento y seguridad. Las variables cualitativas se reportan en frecuencias, y los eventos adversos en tasas de incidencia. Resultados: Un total 237 pacientes fueron elegibles para analizar el perfil de seguridad, con una edad media de 26,5 ± 5,9 años. No se reportaron embarazos. El 32,9% (n = 78) de las pacientes presentaron 213 eventos adversos (IC95%: 26,97-39,29%), con una incidencia de 285.7 por 100 personas-año (IC95%: 248.8-326.6). La incidencia de eventos adversos serios fue de 4.0 por 100 personas-año (IC95%: 0.8-11.7). Conclusiones: Mesigyna® es un método anticonceptivo con un perfil de seguridad favorable, de acuerdo con los resultados observados en los estudios clínicos de la molécula y en la literatura.

Abstract Introduction: Heart failure, a disease with high prevalence and mortality, presents low incorporation of palliative care (PC) despite its necessity. In Colombia, the lack of indicators to monitor the integration of PC in the treatment of heart failure hinders the implementation of effective strategies. It is proposed to use a classification model to monitor the integration of palliative care in the Colombian health system. Objective: To reach a consensus on a set of indicators evaluated for their relevance and feasibility to monitor the integration of palliative care in heart failure in the Colombian health system. Method: A Delphi consensus process was carried out in two rounds, including experts from different regions of the country. An online survey was used on nine indicators related to the integration of palliative care in heart failure in the Colombian health system. Each indicator was evaluated for its relevance and feasibility. Results: Seventeen experts from all regions of Colombia participated, 76% were physicians and 24% nursing professionals; the vast majority (65%) belonged to scientific societies such as the Colombian Association of Palliative Care. All the indicators scored > 7.0 with respect to their relevance and feasibility. The Advance directives in people with heart failure indicator was considered the most relevant and feasible followed by home palliative care for people with heart failure. Conclusions: Based on feasibility and relevance there was consensus on eight of the nine indicators proposed to evaluate the integration of palliative care in the treatment of heart failure in Colombia.

Resumen Introducción: La insuficiencia cardíaca, enfermedad con alta prevalencia y mortalidad, presenta baja incorporación de cuidados paliativos (CP) a pesar de su necesidad. En Colombia, la falta de indicadores para monitorear la integración de CP en el tratamiento de la insuficiencia cardíaca dificulta la implementación de estrategias efectivas. Se propone utilizar un modelo de clasificación para monitorear la integración de CP en el sistema de salud colombiano. Objetivo: Consensuar un conjunto de indicadores evaluados por su relevancia y factibilidad para monitorear la integración de cuidados paliativos en insuficiencia cardíaca en el sistema de salud colombiano. Método: Se realizó un proceso de consenso Delphi en dos rondas, incluyendo expertos de las distintas regiones del país. Se utilizó una encuesta en línea sobre nueve indicadores relacionados con la integración de cuidados paliativos en insuficiencia cardíaca en el sistema de salud colombiano. Se valoró en cada indicador su relevancia y factibilidad. Resultados: Participaron 17 expertos de todas las regiones de Colombia, el 76% eran médicos y el 24% profesionales de enfermería; en su gran mayoría (65%) pertenecían a sociedades científicas como la Asociación Colombiana de Cuidados Paliativos. Todos los indicadores alcanzaron un puntaje > 7.0 con respecto a su relevancia y factibilidad. El indicador Voluntad anticipada en personas con insuficiencia cardíaca fue considerado el más relevante y factible, seguido de Cuidados paliativos domiciliarios para personas con insuficiencia cardíaca. Conclusiones: Se consensuaron ocho de los nueve indicadores propuestos para evaluar la integración de los cuidados paliativos en el tratamiento de insuficiencia cardíaca en Colombia.

Replacing traditional stirrups with high-strength rectangular spiral stirrups can improve the seismic performance of reinforced concrete columns. In order to study the seismic performance of high-strength spiral stirrup confined concrete columns, a validated finite element (FE) method was proposed to establish the FE model of reinforced concrete columns. Combined with the measured data of two existing specimens, parameter analysis was conducted on 19 specimens. The axial compression ratio, shear span ratio, stirrup spacing, and stirrup diameter were variable parameters. Based on a reliable model, internal stress analysis was conducted, and the influence of different variables on the seismic performance of reinforced concrete columns was revealed. The FE results suggest that, when the axial compression ratio is not greater than 0.6, the requirement of ductility greater than 3 in the Chinese Standard GB 50011-2010 can be met. The recommended shear span ratio for optimal ductility was around 4.5. The reinforcement ratio of high-strength spiral stirrups ranges from 1.0% to 2.2%. After completing the simulation of nearly 100 specimens (only calculating the ductility coefficient), a matching relationship between the axial compression ratio limit and the shear span ratio was proposed.

Resumen El FIRES (síndrome epiléptico relacionado con una infección febril) es un síndrome epiléptico poco frecuente que ocurre a cualquier edad en pacientes previamente sanos. Clínicamente presenta episodios febriles en un periodo de 24 horas a dos semanas previas al inicio del estatus epiléptico. Se consideran dos estadios de la enfermedad: estadio agudo, donde existe refractariedad al tratamiento de las convulsiones durante varias semanas, seguido por un estadio crónico en el cual la epilepsia es intratable, acompañado de diferentes grados de deterioro cognitivo. El estadio agudo se caracteriza por un estudio de resonancia magnética (RM) cerebral normal en la mayoría de los casos. Sin embargo el lóbulo temporal, así como las estructuras temporo-mesiales e hipocampo, pueden verse afectados. En el estadio crónico de la enfermedad, la atrofia difusa y/o esclerosis temporo-mesial unilateral o bilateral puede ser el hallazgo principal; no obstante también es posible una evolución sin lesiones secuelares. Comprender estas anomalías en la RM permite respaldar el diagnóstico de FIRES en el contexto de un paciente con epilepsia refractaria, ya que es un diagnóstico de exclusión.

Abstract FIRES (febrile infection-related epilepsy syndrome) is a rare epileptic syndrome occurring at any age in previously healthy patients. Clinically it presents with febrile episodes within 24 hours to two weeks prior to the onset of status epilepticus. Two phases or stages of the disease are considered: in the acute phase there is refractoriness in the treatment of seizures for several weeks, followed by a chronic phase in which epilepsy is intractable, accompanied by varying degrees of cognitive impairment. The acute phase is characterized by a normal brain magnetic resonance imaging (MRI) study in most cases. The temporal lobe including the temporo-mesial structures and hippocampus may be affected. In the chronic phase of the disease diffuse atrophy and/or uni- or bilateral temporo-mesial sclerosis may be found, a course without sequelae lesions is also possible. It is necessary to understand these abnormalities on MRI to support the diagnosis of FIRES as it is a diagnosis of exclusion.

Resumen Las organizaciones están integrando cada vez más cuestiones ambientales en sus planes estratégicos. Así, esta investigación analiza cómo la estrategia de negocios sustentable (GBS, por sus siglas en inglés) y la responsabilidad social corporativa (CSR, por sus siglas en inglés) impactan en el rendimiento financiero (FP, por sus siglas en inglés). Además, se analiza el rol mediador de la CSR en la relación entre la GBS y el FP. El estudio empírico utiliza el modelado de ecuaciones estructurales en una muestra de 300 empresas manufactureras de México. Los resultados muestran relaciones positivas y significativas entre la GBS, la CSR y el FP, mientras que también se verificó el papel mediador significativamente positivo de la CSR. Por lo tanto, los objetivos ambientales establecidos por la GBS contribuyen al FP de las empresas manufactureras mexicanas. La CSR también colabora en este sentido, pero solo parcialmente al mediar la relación entre la GBS y el FP. Los hallazgos respaldan la importancia de incorporar cuestiones ambientales en la planeación estratégica de las empresas para garantizar no solo beneficios económicos, sino también sociales a través de las actividades de GBS y CSR.

Abstract Organizations are increasingly integrating environmental concerns in their strategic plans. This research analyzes how green business strategy (GBS) and corporate social responsibility (CSR) impact financial performance (FP). In addition, we analyze the mediating role of CSR in the relationship between GBS and FP. The empirical application uses structural equation modeling on a sample of 300 manufacturing firms from Mexico. The results show positive and significant relationships between GBS, CSR and FP, while the significantly positive mediating role of CSR was also verified. Thus, the environmental objectives set by the GBS contribute to the FP of Mexican manufacturing firms. CSR also collaborates to this end but only partially by mediating the relationship between GBS and FP. The findings support the importance of incorporating environmental concerns in businesses' strategic planning in order to ensure not only economic but also social benefits through GBS and CSR activities.

Resumen Introducción: El tabaquismo es un problema de salud pública. Existe una asociación entre el tabaquismo y el desarrollo de depresión perinatal. Objetivo: Estimar la prevalencia de la depresión prenatal y analizar los factores de riesgo que predicen el desarrollo de depresión prenatal en un grupo representativo de mujeres españolas gestantes fumadoras. Método: Se llevó a cabo un estudio transversal en una muestra de 1.524 de embarazadas en el primer trimestre de gestación. Se les administró el Cuestionario de salud del paciente (PHQ-9) y el Inventario revisado de predictores de depresión posparto (PDPI-R). Resultados: Se encontró una tasa de depresión antenatal en mujeres fumadoras del 25,6%. Se encontraron como predictores de depresión prenatal en fumadoras el estresor de enfermedad grave de un familiar y la falta de apoyo emocional de la pareja. Conclusiones: La falta de apoyo social y la carencia de estrategias adaptativas de afrontamiento del estrés es posible que hagan más proclive que la mujer continúe fumando en el embarazo y aumentan el riesgo de depresión perinatal.

Abstract Introduction: Smoking is a public health problem. There is an association between smoking and the development of perinatal depression. Objective: Estimate the prevalence of prenatal depression and analyze the risk factors that predict the development of prenatal depression in a representative group of Spanish pregnant women who smoke. Method: A cross-sectional study was carried out in a sample of 1,524 pregnant women in the first trimester of pregnancy. The Patient Health Questionnaire (PHQ-9) and the Revised Postpartum Depression Predictors Inventory (PDPI-R) were administered. Results: A rate of prenatal depression in smoking women was found to be 25.6%. The stressor of a serious illness in a family member and the lack of emotional support from the partner were found as predictors of prenatal depression in smokers. Conclusions: The lack of social support and the lack of adaptive strategies for coping with stress may make it more likely for women to continue smoking during pregnancy and increase the risk of perinatal depression.

Abstract This study aimed to evaluate the efficacy of nonpharmacological interventions beyond the known and effective lifestyle interventions, as an adjunct to the treatment of adult patients with hypertension, a significant risk factor for fatal cardiovascular diseases. The evaluated interventions included alternative therapies, like traditional Chinese medicine and acupuncture (three studies), mind-body therapy (10 studies) and dietetic/nutraceutical supplements (10 studies). The results suggest that some of these therapies may be promising adjuncts to antihypertensive treatment. Among the mentioned therapies, auricular acupressure, tai chi, yoga, qigong and meditation stand out. In addition, certain nutraceuticals and phytotherapeutic agents like omega-3 fatty acids, coenzyme Q10, vitamin C, probiotics, resveratrol, soy isoflavones, garlic extract and extra virgin olive oil may be recommended as part of a healthy diet, like the Mediterranean or DASH diet, known for its impact on cardiovascular risk. In conclusion, as far as public policies aimed at the comprehensive treatment of chronic noncommunicable diseases are concerned, these therapies, as part of nonpharmacological management, can effectively complement hypertension treatment, providing patients with additional options for controlling their blood pressure and improving their cardiovascular health. However, more research is needed to confirm their long-term efficacy and safety.

Resumen Este estudio se dirigió a evaluar la eficacia de intervenciones no farmacológicas más allá de las conocidas y efectivas intervenciones en el estilo de vida como complemento al tratamiento de pacientes adultos con diagnóstico de hipertensión arterial, factor de riesgo significativo para enfermedades cardiovasculares mortales. Entre las intervenciones evaluadas, se incluyeron las terapias alternativas, como la medicina tradicional china y la acupuntura (tres estudios), las terapias mente-cuerpo (diez estudios) y la suplementación con productos dietéticos/nutracéuticos (diez estudios). Los resultados sugieren que algunas de estas terapias pueden ser prometedoras como complemento al tratamiento antihipertensivo. Entre las terapias mencionadas, se destacan la acupresión auricular, el taichi, el yoga, el qigong y la meditación. Además, ciertos nutracéuticos y fitoterapéuticos, como los ácidos grasos omega 3, la coenzima Q10, la vitamina C, los probióticos, el resveratrol, las isoflavonas de soja, el extracto de ajo y el aceite de oliva extravirgen, pueden ser recomendados como parte de una dieta saludable, como la dieta mediterránea o DASH, reconocida por su impacto en el riesgo cardiovascular. En conclusión, en lo que respecta a las políticas públicas dirigidas al manejo integral de las enfermedades crónicas no transmisibles, estas terapias, dentro del manejo no farmacológico, pueden complementar eficazmente el tratamiento de la hipertensión arterial, brindando a los pacientes opciones adicionales para controlar su presión arterial y mejorar su salud cardiovascular. Sin embargo, se necesita más investigación para confirmar su eficacia y seguridad a largo plazo.