Objective: To assess the impact and correlation of socioeconomic vulnerability on COVID-19 outcomes and social distancing in Brazil. Methods: The Gini Coefficient (GC), the Social Vulnerability Index (SVI), epidemiological data on COVID-19 epidemic in Brazil, and the Social Distancing Index (SDI) were retrieved from online databases and assessed for each Brazilian state. Data was statistically analyzed through non-parametric tests and multiple linear regressions. Results: The mean values for the GC and SVI were 0.495 and 0.261, respectively. A positive statistically significant correlation between the socioeconomic indicators and the three variables related to the COVID-19 outbreak was found. States with very low social vulnerability presented fewer deaths per 100 thousand inhabitants due to COVID-19 than states with moderate social vulnerability. SVI was a predictor of accumulated cases, confirmed deaths, and social distancing in Brazilian states during COVID-19. Conclusions: The COVID-19 outcomes and SDI in Brazilian states are correlated to the socioeconomic condition. The pandemic impacts are more severe in less favored communities.

Objetivo: Avaliar o impacto e a correlação da vulnerabilidade socioeconômica nos desfechos da COVID-19 e no distanciamento social no Brasil. Materiais e Métodos: O Coeficiente de Gini (CG), o Índice de Vulnerabilidade Social (IVS), dados epidemiológicos sobre a epidemia da COVID-19 no Brasil e o Índice de Distanciamento Social (IDS) foram obtidos a partir de bases de dados online e avaliados para cada estado brasileiro. Os dados foram analisados estatisticamente através de testes não-paramétricos e de regressão logística linear. Resultados: Os valores médios para o CG e IVS foram 0.495 e 0.261, respectivamente. Uma correlação estatística positiva foi encontrada entre os indicadores socioeconômicos e as três variáveis relacionadas à epidemia de COVID-19. Os estados brasileiros com menores índices de vulnerabilidade social apresentaram uma quantidade menor de mortes pela COVID-19, para cada cem mil habitantes, quando comparados com estados com vulnerabilidade social moderada. O IVS foi um preditor para o acumulado de casos, mortes confirmadas e distanciamento social nos estados brasileiros durante a pandemia da COVID-19. Conclusão: Os desfechos da COVID-19 e o IDS nos estados brasileiros estão correlacionados com a condição socioeconômica. Os impactos da pandemia são mais severos nas localidades mais vulneráveis.

RESUMO O atendimento odontológico hospitalar é uma estratégia educativa e assistencial que tem como objetivo intervir, de forma multidisciplinar, no processo saúde-doença de indivíduos vulneráveis, uma vez que a saúde bucal insatisfatória é um fator de risco para infecções locais e sistêmicas. Pacientes em tratamento oncológico geralmente apresentam manifestações orais por causa das terapias antineoplásicas às quais são submetidos. Quimioterapia, radioterapia e cirurgia oncológica, quando realizadas na região da cabeça e pescoço, têm o potencial de gerar efeitos colaterais na cavidade bucal. Essas manifestações orais podem ser graves e interferir nos resultados da terapia medicamentosa, levando a importantes complicações sistêmicas, que podem aumentar a permanência hospitalar, os custos do tratamento e afetar a qualidade de vida. Diante dessa realidade, a incorporação do cirurgião-dentista na equipe multiprofissional em oncologia é fundamental para garantir a integralidade do cuidado em todas as etapas da terapia. Este artigo se propõe a relatar uma série de casos de pacientes atendidos no Serviço de Odontologia do Centro de Oncologia do Hospital Universitário Oswaldo Cruz da Universidade de Pernambuco, que exemplificam possibilidades de atuação do cirurgião-dentista em ambiente hospitalar, participando como membro ativo de uma equipe multidisciplinar em oncologia.

ABTRACT Hospital dental care is an educational and health care strategy whose purpose is to intervene, in a multidisciplinary way, in the health-disease process of vulnerable individuals, as unsatisfactory oral health is a risk factor for local and systemic infections. Patients in cancer treatment usually present oral manifestations because of the antineoplastic therapies to which they are submitted. Chemotherapy, radiation and cancer surgery, when the latter held in the head and neck region, have the potential to generate side effects in the oral cavity. These oral manifestations can be serious and interfere with the results of medical therapy, leading to important systemic complications, which can increase hospital stay, treatment costs, and affect the quality of life. In view of this reality, the incorporation of the dentist into the multiprofessional team in oncology is essential to guarantee the patient’s integral care in all stages of therapy. This article then proposes to report a series of cases of patients attended at the Dentistry Service of the Oncology Center of the Oswaldo Cruz University Hospital of the University of Pernambuco, that exemplify the dental surgeon performance in a hospital environment, participating as an active member of a multidisciplinary team in oncology.

ABSTRACT Lippia origanoides is a honey shrub which has showed hypotensive potential assessed by in vivo studies. The aim of this work is the development of a pharmaceutical formulation composed by an optimized extract obtained from aerial parts of L. origanoides. The quantification of the naringenin marker in the dry extract and tablets developed was performed, as well as the assessment of the oral acute toxicity in rats. The hydroalcoholic extract of L. origanoides was spray-dried with the addition of colloidal silicon dioxide (Lo-HAE/CSD), and then applied in the preparation of eight different lots of tablets. The influence of the diluent (cellulose or babassu mesocarp), the presence of binder, and the percentage of lubricant, as well as organoleptic and physicochemical characteristics were screened. For the quantification of the marker content both in Lo-HAE/CSD and in the tablets, an analytical curve of the naringenin standard was fitted, and the samples were then analyzed in UFLC. The toxicological assessment was performed in female Wistar rats according to the Acute Toxic Class Method from OECD. The developed tablets produced meet acceptable macroscopic characteristics, and the presence of babassu as diluent provided improved physicochemical properties. The best content of Lo-HAE/CSD in the tablet (100.27%) was identified for the lot containing babassu, composed by 1.0% magnesium stearate, without PVP binder in its formulation. Moreover, Lo-HAE/CSD showed no signs of toxicity. Therefore, the babassu mesocarp powder is a promising pharmaceutical excipient for the development of herbal tablets containing the Lippia origanoides extract.