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Hepatitis autoinmune seronegativa
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Gómez Pastrana, Juan Carlos

; Beleño, Álvaro

; Martinez, Mauricio

; Cavanagh, Ignacio

; Jimenez, Juan

Medicina (Buenos Aires)

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aug 2024, Volume 84 N. 3 Pages 534 - 543

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La hepatitis autoinmune (HAI) es una enfermedad inflamatoria y necrótica del hígado, crónica e infre cuente caracterizada por la presencia de autoanti cuerpos. Su etiología es desconocida. Afecta a 1 de cada 200 000 personas anualmente en los EE. UU. y se presenta predominantemente en mujeres. Su presenta ción varía desde formas asintomáticas hasta la cirrosis y falla hepática aguda y su diagnóstico se basa en la medición de autoanticuerpos, como los autoanticuer pos antinucleares (ANA), anticuerpos antimúsculo liso (ASMA) y anticuerpos antimicrosomales de hígado y riñón (anti-LKM-1). El 10% de las HAI no presentan anti cuerpos, denominándose HAI seronegativa, necesitando biopsia hepática para el diagnóstico. Hasta la fecha la evidencia sigue siendo limitada y diferentes sociedades han emitido sugerencias y recomendaciones. Por tal motivo creemos relevante realizar una revisión biblio gráfica sobre el tema plasmando en este documento la información importante para la compresión y el manejo de esta patología.

Abstract Autoimmune hepatitis (AIH) is a rare, chronic, inflam matory, and necrotic liver disease characterized by the presence of autoantibodies. Its etiology is unknown. It affects 1 in 200 000 people annually in the US and oc curs predominantly in women. Its presentation varies from asymptomatic forms to cirrhosis and acute liver failure and its diagnosis is based on the measurement of autoantibodies, such as antinuclear autoantibod ies (ANA), anti-smooth muscle antibodies (ASMA) and anti-liver and kidney microsomal antibodies (anti-LKM). 1). 10% of HAIs do not present antibodies, being called seronegative HAI, requiring a liver biopsy for diagnosis. To date the evidence remains limited and different so cieties have issued suggestions and recommendations. For this reason, we believe it is relevant to carry out a bibliographic review on the subject, capturing in this document the important information for the under standing and management of this pathology.

Reflectance confocal microscopy - Consensus terminology glossary in Brazilian Portuguese for normal skin, melanocytic and non-melanocytic lesions skin nonmelanocytic non
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Braga, Juliana Casagrande Tavoloni

; Barcaui, Carlos B.

; Pinheiro, Ana Maria

; Sortino, Ana Maria Fagundes

; Abdalla, Cristina Martinez Zugaib

; Campos-do-Carmo, Gabriella

; Rezze, Gisele Gargantini

; Pineiro-Maceira, Juan

; Rocha, Lilian Licarião

; Maia, Marcus

; Sá, Bianca Costa Soares de

Anais Brasileiros de Dermatologia

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jan 2024, Volume 99 N. 1 Pages 100 - 110

Abstract: En | Text: En | PDF: En

Abstract Background: Currently, there is no uniform and official terminology in Portuguese for reflectance confocal microscopy analysis, despite the increasing number of Brazilian dermatologists using this new tool. Objective: To present the terminology in Brazilian Portuguese for the description of reflectance confocal microscopy and establish the first Brazilian consensus on terms related to normal skin and cutaneous tumors. Methods: 10 Brazilian specialists from different institutions and states of Brazil were selected to evaluate the best corresponding terms in Portuguese for normal skin, melanocytic and non-melanocytic tumors. The terms used were translated from international consensuses in the English language. The modified Delphi method was used to create the consensus in 3 steps. Results: The terms considered the most appropriate in the Portuguese language to describe the findings of normal skin, melanocytic and non-melanocytic lesions in the reflectance confocal microscopy analysis were presented. Study limitations: The limitations of the present study include the number of participants and limited regional representation (only two of the five Brazilian regions were represented). Conclusion: This Brazilian consensus represents an opportunity for dermatologists and physicians specializing in cutaneous oncology to become familiar with reflectance confocal microscopy, propagating the technique in clinical and research environments to stimulate national and international publications on this subject. Background Currently tool Objective tumors Methods 1 nonmelanocytic non steps Results presented only represented. represented . represented) Conclusion subject

https://doi.org/10.1016/j.abd.2023.05.001

Dermoscopy of pityriasis lichenoides et varioliformis acuta (PLEVA) PLEVA (PLEVA
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Arias-Rodriguez, Camilo

; Hoyos-Gaviria, Juan Guillermo

; Muñoz-Monsalve, Ana María

; Hernandez-Martinez, Alejandro

Anais Brasileiros de Dermatologia

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jan 2024, Volume 99 N. 1 Pages 120 - 123

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.abd.2022.04.017

Patients’ perception on stressful events for fibromyalgia development Patients
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Oliveira, Ana Julia Campi Nunes de

; Di-Giovanni, Thaís

; Vanzelli, Cassiano Henrique Giovanini

; Araujo, Bruno de Mendonça Moraes

; Gianini, Reinaldo José

; Martinez, José Eduardo

BrJP

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2024, Volume 7 elocation e20240051

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND AND OBJECTIVES: Fibromyalgia syndrome (FM) is a rheumatic disease with the following characteristics: generalized chronic pain, fatigue, non-restorative sleep and cognitive disturbances. It is often associated to distress followed chronic and acute stressors exposures. The objective of this study was to determine the patients’ perception if stressful events influence the development of FM. The secondary objective was to evaluate the impact of acute stress in determining the future severity of FM. METHODS: A cross-sectional study was carried out for the primary objective and a case-control study for the secondary objective. We used questionnaires on demographic data and instruments for assessing the severity and impact of FM (Fibromyalgia Index - FI, and Revised Fibromyalgia Impact Questionnaire - FIQr), instruments for assessing emotional aspects (PHQ-9 and GAD-7), and a questionnaire on patients’ perception of stressful events. RESULTS: Sixty-one patients were evaluated. About 59% reported the presence of acute stress as an aggravating factor. Patients mentioned grief for a close relative, financial problems, family conflicts, and being a victim of violence as aggravating events. There was a significant association between the presence of stressful incidents, FI and FIQr (p<0.05). The presence of aggravating circumstances increased the FIQr score by 2.72. CONCLUSION: It was observed a significant association between aggravating stressful events and higher index FM scores and their impact on the patients. OBJECTIVES (FM characteristics pain fatigue nonrestorative non restorative disturbances exposures METHODS crosssectional cross sectional casecontrol case control FIQr, , FIQr) PHQ9 PHQ 9 (PHQ- GAD7, GAD7 GAD 7 GAD-7) RESULTS Sixtyone Sixty one evaluated 59 factor relative problems conflicts incidents p<0.05. p005 p p<0.05 . 0 05 (p<0.05) 272 2 72 2.72 CONCLUSION (PHQ GAD-7 5 p00 p<0.0 (p<0.05 27 2.7 GAD- p0 p<0. (p<0.0 2. p<0 (p<0. p< (p<0 (p< (p

RESUMO JUSTIFICATIVA E OBJETIVOS: A síndrome da fibromialgia (FM) é uma doença reumática com as seguintes características: dor crônica generalizada, fadiga, sono não restaurador e distúrbios cognitivos. Ela é frequentemente associada à angústia após exposições a estressores crônicos e agudos. O objetivo deste estudo foi determinar a percepção dos pacientes se os eventos estressantes influenciam o desenvolvimento da FM. O objetivo secundário foi avaliar o impacto do estresse agudo na determinação da gravidade futura da FM. MÉTODOS: Foram realizados um estudo transversal para o objetivo primário e um estudo de caso controle para o objetivo secundário. Foram utilizados questionários sobre dados demográficos e instrumentos de avaliação da gravidade e impacto da FM (Índice Fibromiálgico - FI, e Revised Fibromyalgia Impact Questionnarie - FIQr), instrumentos de avaliação de aspectos emocionais (PHQ-9 e GAD-7), e um questionário sobre a percepção dos pacientes em relação aos eventos estressores. RESULTADOS: Sessenta e um pacientes foram avaliados. Cerca de 59% relataram a presença de estresse agudo como um fator agravante. Os pacientes mencionaram o luto por um parente próximo, problemas financeiros, conflitos familiares e serem vítimas de violência como eventos agravantes. Houve associação significativa entre a presença de incidentes estressantes, FI e FIQr (p<0,05). A presença de circunstâncias agravantes aumentou o escore do FIQr em 2,72. CONCLUSÃO: Foi observada associação significativa entre eventos estressantes agravantes e pontuações mais altas do índice de FM e seu impacto sobre os pacientes. OBJETIVOS (FM características generalizada fadiga cognitivos agudos MÉTODOS Índice FIQr, , FIQr) PHQ9 PHQ 9 (PHQ- GAD7, GAD7 GAD 7 GAD-7) RESULTADOS avaliados 59 agravante próximo financeiros p<0,05. p005 p p<0,05 . 0 05 (p<0,05) 272 2 72 2,72 CONCLUSÃO (PHQ GAD-7 5 p00 p<0,0 (p<0,05 27 2,7 GAD- p0 p<0, (p<0,0 2, p<0 (p<0, p< (p<0 (p< (p

https://doi.org/10.5935/2595-0118.20240051-en

Socioeconomic factors and COVID-19 mortality in immune-mediated rheumatic diseases patients: regional analysis from Argentina, Mexico and Brazil COVID19 COVID 19 COVID-1 immunemediated immune mediated patients Argentina COVID1 1 COVID-
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Martinez-Martinez, Marco Ulises

; Isnardi, Carolina Ayelen

; Alpizar-Rodriguez, Deshiré

; Pons-Estel, Guillermo Javier

; Virasoro, Belén María

; Alfaro, María Agustina

; Petkovic, Ingrid

; Quintana, Rosana

; Berbotto, Guillermo

; Salinas, María Jezabel Haye

; Ornella, Sofía

; Pera, Mariana

; Colunga-Pedraza, Iris Jazmín

; Irazoque-Palazuelos, Fedra

; Reyes-Cordero, Greta

; Rodriguez-Reyna, Tatiana S

; Veloz-Aranda, Jose Antonio

; Skinner-Taylor, Cassandra Michele

; Juárez-Mora, Ingrid Maribel

; Silveira, Luis H.

; Marques, Claudia Diniz Lopes

; Xavier, Ricardo Machado

; Kakehasi, Adriana Maria

; Gomides, Ana Paula

; Reis-Neto, Edgard Torres dos

; Pileggi, Gecilmara Salviato

; Ferreira, Gilda Aparecida

; Mota, Licia Maria Henrique da

; Pinheiro, Marcelo Medeiros

; Calderaro, Débora Cerqueira

Advances in Rheumatology

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2024, Volume 64 elocation 78

Abstract: En | Text: En | PDF: En

Abstract Background SARS-CoV-2 infection has become a major international issue, not only from a medical point of view, but also social, economic and political. Most of the available information comes from the United States, Europe, and China, where the population and the socioeconomic status are very different from Latin American countries. This study evaluates the effect of regional socioeconomic characteristics on mortality due SARS-CoV-2 infection in patients with immune-mediated rheumatic diseases (IMRD) from Argentina, Mexico and Brazil. Methods Data from three national registries, SAR-COVID (Argentina), CMR-COVID (Mexico) and ReumaCoV-Brasil (Brazil), were combined. Adult IMRD patients with SARS-CoV-2 infection were recruited. National data for each province/state, including population density, number of physicians per inhabitant, income, unemployment, GINI index, Municipal Human Development Index (MHDI), stringency index, vaccination rate and most frequent viral strains per period were assessed as risk factors for mortality due to COVID-19. Results A total of 4744 patients were included, 2534 (53.4%) from SAR-COVID, 1166 (24.6%) from CMRCOVID and 1044 (22.0%) from ReumaCoV-Brasil. Mortality due to COVID-19 was 5.4%. In the multivariable analysis, higher number of physicians per 1000 inhabitants and being infected during the vaccination period of each country were associated with lower mortality. After adjustment for socioeconomic factors, there was no association with country of residence and mortality. Conclusion These findings corroborate the complex interplay between socioeconomic factors, rheumatic disease activity, and regional disparities as determinants of death due to COVID-19 in Argentina, Brazil and Mexico. Thus, this research provides valuable insights for guiding public health policies and clinical practice in the ongoing fight against the COVID-19 pandemic. SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- issue view social political States Europe China countries immunemediated immune mediated (IMRD Argentina registries SARCOVID SAR COVID , (Argentina) CMR (Mexico ReumaCoVBrasil ReumaCoV Brasil Brazil, (Brazil) combined recruited provincestate province state province/state density inhabitant income unemployment index MHDI, MHDI (MHDI) COVID19. COVID19 19. 19 474 included 253 53.4% 534 53 4 (53.4% SARCOVID, COVID, 116 24.6% 246 24 6 (24.6% 104 22.0% 220 22 0 (22.0% ReumaCoVBrasil. Brasil. COVID-1 54 5 5.4% analysis 100 activity Thus pandemic SARS-CoV (Argentina (Brazil (MHDI COVID1 1 47 25 53.4 (53.4 11 24.6 (24.6 10 22.0 (22.0 COVID- 5.4 53. (53. 24. (24. 22. (22. 5. (53 (24 (22 (5 (2 (

https://doi.org/10.1186/s42358-024-00418-3

Rede social de famílias envolvidas na negligência contra crianças e adolescentes: construindo um olhar multidimensional adolescentes
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Sabino, Fabiano Henrique Oliveira

; Soares, Ana Paula de Miranda Araújo

; Pacheco, Ingrid

; Martinez, Nathalia Vitória de Carvalho

; Françoloso, Maísa Rodrigues

; Carlos, Diene Monique

Ciência & Saúde Coletiva

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2024, Volume 29 N. 7 elocation e03132024

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Neglect is one of the most frequently reported forms of violence against children and adolescents, although it has rarely been explored in national studies. In this light, the present study aimed to analyze the personal social network of families involved in negligence against children and adolescents. This work takes a qualitative approach, anchored in the Paradigm of Complexity, conducted with twenty families involved in negligence against children and adolescents in a municipality in the countryside of the state of São Paulo, Brazil. Data collection took place through minimal maps of the personal social network and semi-structured interviews in January 2021. The networks were limited, with little to no interaction among the different services and sectors, and were predominantly homogeneous. Because they have many weakened ties, they are relatively unsupportive, pointing out difficulties in access to work, education, and health. Due to the characteristics of the network, the complexity of the phenomenon of neglect was identified, in which elements condition and perpetuate experiences of absence and fragility. Interprofessional and intersectoral views and actions are requested and recommended. studies light approach Complexity Paulo Brazil semistructured semi structured 2021 limited sectors homogeneous ties unsupportive education health identified fragility recommended 202 20 2

Resumo A negligência constitui uma das violências contra crianças e adolescentes mais notificadas, entretanto ainda pouco explorada em estudos nacionais. O objetivo deste estudo foi analisar a rede pessoal social de famílias envolvidas na negligência contra crianças e adolescentes. Estudo qualitativo, ancorado no paradigma da complexidade, realizado junto a 20 familiares envolvidos na negligência contra crianças e adolescentes em município do interior de São Paulo, Brasil. A coleta de dados se deu por mapas mínimos da rede pessoal social e entrevistas semiestruturadas em janeiro de 2021. As redes se apresentaram reduzidas, com pouca ou nenhuma articulação entre os diferentes serviços e setores e predominantemente homogêneas. Por terem muitos vínculos fragilizados, mostrou-se pouco sustentadora, apontando dificuldades no acesso a trabalho, educação e saúde. Pelas características da rede, identificou-se a complexidade do fenômeno da negligência, em que elementos condicionam e perpetuam vivências de ausências e fragilidades. Olhares e ações interprofissionais e intersetoriais são pleiteadas e recomendadas. notificadas nacionais qualitativo 2 Paulo Brasil 2021 reduzidas homogêneas fragilizados mostrouse mostrou sustentadora trabalho saúde identificouse identificou fragilidades recomendadas 202

https://doi.org/10.1590/1413-81232024297.03132024

Unusual Anastomosis between Branches of the Ulnar Nerve (Kaplan Type Anastomotic Variant) – Case Report Kaplan Variant
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Oliveira, Kennedy Martinez

; Benevenuto, Gabriel das Chagas

; Ferreira de Almeida, Ana Clara

; Gonçalves de Oliveira, Daniel

; Bueno, Leonardo Braga

; Teixeira, Maria Fernanda Carvalho

Revista Brasileira de Ortopedia

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2024, Volume 59 Suppl. 1 Pages 65 - 67

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract The Kaplan anastomosis is a rare communication originally described between the superficial and dorsal branches of the ulnar nerve, distal to the ulnar tunnel, and in strict relation with the pisiform bone. It reveals, by its particular location, a formation of high clinical-surgical expressiveness. In this paper, we describe a Kaplan-type communication from a left upper limb with an unusual loop conformation between branches of the ulnar nerve in the pisiform bone. tunnel bone reveals location clinicalsurgical clinical surgical expressiveness paper Kaplantype type

Resumo A anastomose de Kaplan é uma rara comunicação originalmente descrita entre os ramos superficial e dorsal do nervo ulnar, distal ao túnel ulnar e em estreita relação com o osso pisiforme. O que revela, pela sua particular localização, uma formação de alta expressividade clínico-cirúrgica. Neste trabalho, uma comunicação do tipo Kaplan, porém, ainda não relatada, é descrita a partir de um membro superior esquerdo com uma inusual conformação em alça, ou um looping, entre ramos do nervo ulnar, no osso pisiforme. pisiforme revela localização clínicocirúrgica. clínicocirúrgica clínico cirúrgica. cirúrgica clínico-cirúrgica trabalho porém relatada alça looping

https://doi.org/10.1055/s-0042-1744295

Disseminated sporotrichosis with osteoarticular involvement in a patient with acquired immunodeficiency syndrome: a case report syndrome
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Santos, Ana Paula Freitas Bahia dos

; Mota, Ana Carolina de Oliveira

; Jesus, Gabriel Ramalho de

; Rocha, Matheus Dias Girão

; Durço, Daniela de Freitas Pereira Calheiros Ângelo

; Rezende, Luis Guilherme Rosifini Alves

; Silva, Anna Christina Tojal da

; Vilar, Fernando Crivelenti

; Bollela, Valdes Roberto

; Martinez, Roberto

Revista da Sociedade Brasileira de Medicina Tropical

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2024, Volume 57 elocation e00809-2024

Abstract: En | Text: En | PDF: En

ABSTRACT Sporotrichosis is caused by fungi belonging to the genus Sporothrix, and is generally acquired by traumatic inoculation. A 26-year-old man developed pustular lesions and a 6-kg weight loss after developing a lesion on his right hand 6 months previously. He was diagnosed with acquired human immunodeficiency syndrome (AIDS) and disseminated sporotrichosis cultures of bone and muscle biopsy and blood samples grew Sporothrix schenckii. The patient underwent reconstructive surgery and 9 months of treatment with amphotericin B and itraconazole, and showed complete wound healing and improved hand functionality. Suspicion of the disease is necessary in immunosuppressed patients living in endemic areas. inoculation 26yearold yearold 26 year old 6kg kg previously AIDS (AIDS schenckii itraconazole functionality areas 2

https://doi.org/10.1590/0037-8682-0120-2024

Vaccination status and outcomes in critical COVID-19 patients COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Costa, Pedro Nogueira

; Pereira, João Oliveira

; Cañigral, Aurea Higon

; Quintana, Elena Martinez

; Sanchez-Nieto, Juan Miguel

; Delis, Pablo Bayoumy

; Villarroya, Ana Renedo

; Gomez, Laura Lopez

; Fernandez, Nuria Alonso

; Alcaraz, Andrés Carrillo

Jornal Brasileiro de Pneumologia

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2024, Volume 50 N. 1 elocation e20230116

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To analyze the clinical characteristics and outcomes of patients with COVID-19-related acute respiratory failure on the basis of their vaccination status at the time of ICU admission. Methods: We conducted a retrospective observational study using a prospective database of patients admitted to the ICU of a university hospital in the city of Murcia, in Spain, between January 1, 2021 and September 1, 2022. Clinical, analytical, and sociodemographic data were collected and analyzed on the basis of patient vaccination status. We adjusted for confounding variables using propensity score matching and calculated adjusted ORs and 95% CIs. Results: A total of 276 patients were included in the study. Of those, 8.3% were fully vaccinated, 12% were partially vaccinated, and 79.7% were unvaccinated. Although fully vaccinated patients had more comorbidities, partially vaccinated patients had higher disease severity. The proportion of patients with severe acute respiratory failure was higher in the unvaccinated group, followed by the partially vaccinated group. No significant differences were found among the different groups regarding complications, duration of ventilatory support, or length of ICU/hospital stay. In the sample selected by propensity score matching, the number of patients with severe complications and the in-hospital mortality rate were higher in unvaccinated patients, but the differences were not significant. Conclusions: This study failed to show a significant improvement in outcomes in critically ill COVID-19 patients vaccinated against SARS-CoV-2. However, the CIs were wide and the mortality point estimates favored patients who received at least one dose of COVID-19 vaccine. Objective COVID19related COVIDrelated COVID 19 related admission Methods Murcia Spain 1 202 2022 Clinical analytical 95 Results 27 those 83 8 3 8.3 12 797 79 7 79.7 comorbidities severity group support ICUhospital stay inhospital Conclusions COVID19 COVID-1 SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. 2 SARS-CoV-2 However vaccine 20 9 8. 79. COVID1 COVID- SARS-CoV- SARS-CoV

RESUMO Objetivo: Analisar as características clínicas e desfechos de pacientes com insuficiência respiratória aguda por COVID-19 com base na situação vacinal no momento da admissão na UTI. Métodos: Estudo observacional retrospectivo com um banco de dados prospectivo de pacientes admitidos na UTI de um hospital universitário em Múrcia, na Espanha, entre 1º de janeiro de 2021 e 1º de setembro de 2022. Dados clínicos, analíticos e sociodemográficos foram coletados e analisados com base na situação vacinal dos pacientes. Por meio de pareamento por escore de propensão, foram realizados ajustes de modo a levar em conta as variáveis de confusão. Além disso, foram calculadas as OR ajustadas e IC95%. Resultados: Foram incluídos no estudo 276 pacientes. Destes, 8,3% apresentavam vacinação completa, 12% apresentavam vacinação incompleta e 79,7% não haviam sido vacinados. Embora os pacientes com vacinação completa apresentassem mais comorbidades, os com vacinação incompleta apresentavam doença mais grave. A proporção de pacientes com insuficiência respiratória aguda grave foi maior nos não vacinados, seguidos daqueles com vacinação incompleta. Não foram observadas diferenças significativas entre os diferentes grupos quanto a complicações, tempo de suporte ventilatório ou tempo de internação na UTI/hospital. Na amostra selecionada pelo pareamento por escore de propensão, o número de pacientes com complicações graves e a taxa de mortalidade hospitalar foram maiores em pacientes não vacinados, mas as diferenças não foram significativas. Conclusões: Este estudo não conseguiu demonstrar uma melhoria significativa dos desfechos em pacientes com COVID-19 em estado crítico e vacinados contra o SARS-CoV-2. No entanto, os IC foram amplos e as estimativas pontuais de mortalidade favoreceram os pacientes que receberam pelo menos uma dose de vacina contra a COVID-19. Objetivo COVID19 COVID 19 COVID-1 Métodos Múrcia Espanha º 202 2022 clínicos propensão confusão disso IC95 IC95% Resultados 27 Destes 83 8 3 8,3 12 797 79 7 79,7 comorbidades UTIhospital UTI/hospital Conclusões SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. 2 SARS-CoV-2 entanto COVID19. 19. COVID1 1 COVID- 20 IC9 8, 79, SARS-CoV- SARS-CoV

https://doi.org/10.36416/1806-3756/e20230116

10.

Rede social de famílias envolvidas na negligência contra crianças e adolescentes: construindo um olhar multidimensional
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Sabino, Fabiano Henrique Oliveira

; Soares, Ana Paula de Miranda Araújo

; Pacheco, Ingrid

; Martinez, Nathalia Vitória de Carvalho

; Françoloso, Maísa Rodrigues

; Carlos, Diene Monique

Ciência & Saúde Coletiva

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2024, Volume 29 N. 7 elocation e03132024

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1413-81232024297.03132024

11.

Revisores 2023
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Molas de la Quintana, Adriana Beatriz

; Jimenez Genchi, Alejandro

; Carrizales, Alexia

; Gotti, Amanda

; Martinez Ortiz, Ana

; Rocío Martínez Yacelga, Ana del

; Camilo Ciantelli, Ana Paula

; Jimenez Figueroa, Andres

; Neumann, Angélica Paula

; Parodi Svartman, Bernardo

; Vazquez Rodriguez, Carolina

; Da Silva, Cecilia

; Baroni, Cecilia

; Lanza Perez, Cintia Beatriz

; Mola, Débora

; Alarcón Rubio, David

; Perales Mejia, Felipe de Jesús

; Sarachu, Gerardo

; Gelpi, Gonzalo

; Sosa, Gustavo

; Viana Batista, Helder

; Moizéis, Heloísa Bárbara Cunha

; Carrasco, Jimena

; Ungaretti, Joaquín

; Moreira, Karen

; Tomatis, Karina

; Oros, Laura Beatriz

; Mazaro, Lisabelle Manente

; Chiavone, Luciana

; Perilla Toro, Lyria Esperanza

; Campagnoli, Mabel Alicia

; Ruiz Barbot, Mabela

; Brenlla, María Elena

; Folle Chavannes, María Ana

; Freytes Frey, Marcela

; Rossal, Marcelo

; Ortiz, Maria Victoria

; Nabergoi, Mariela

; Montenegro, Marisela

; Lladó, Mónica

; Freitas De León, Paribanú

; Solís García, Patricia

; Ruiz Santos, Paul

; Fiorati, Regina Célia

; Martins, Rita de Cássia Andrade

; Dominguez-Lara, Sergio Alexis

; Herranz, Silvana Melisa

; Yoma, Solana María

; Gondim, Sonia Maria Guedes

; Rostagnol, Susana

; Wittke, Tommy

; Ballesteros, Virginia

; Tamayo, William

Psicología, Conocimiento y Sociedad

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dec 2023, Volume 13 N. 3 Pages 116 - 118

Abstract: Es | Text: Es | PDF: Es

https://doi.org/10.26864/pcs.v13.n3.rev

12.

Eosinophilic enteritis presenting as intestinal obstruction: case report and review of the literature
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Rienzo-Madero, Beatriz de

; Kajomovitz-Bialostozky, Daniel

; Martinez-Munive, Ángel

; Pelaez-Luna, Mario

; Rivera-García-Granados, Ana

; Quijano-Orvañanos, Fernando

Cirugía y cirujanos

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oct 2023, Volume 91 N. 5 Pages 709 - 712

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La enteritis eosinofílica (EE) se caracteriza por infiltrado eosinofilico del tracto GI. Las manifestaciones clínicas dependen de la capa intestinal afectada. Se recomiendan esteroides sistémicos como primera línea de tratamiento, reservando la cirugía para complicaciones. Masculino de 84 años con antecedente de hemicolectomía derecha y dos episodios de oclusión intestinal acude al servicio de urgencias con dolor abdominal, distensión, náusea y vómito. Laboratorio reportó leucocitosis, sin eosinofilia. Tomografía con contraste evidenció estenosis, con engrosamiento de la pared del intestino delgado e imagen compatible con oclusión intestinal. La colonoscopía demostró ulceras en íleon terminal la cual reporto EE. Se inició tratamiento con budesonide y metronidazol, con adecuada respuesta y resolución a las 24 h.

Abstract Eosinophilic enteritis (EE) is characterized by intense eosinophilic infiltrate of the gastrointestinal tract. Clinical manifestations depend on the affected segment and intestinal layer. First-line treatment is systemic corticosteroids; surgery is reserved for complications. 84-year-old male patient with a history of right hemicolectomy and two episodes of intestinal obstruction presented to the ED with abdominal pain, distension, nausea, and vomiting. CBC showed leukocytosis and no eosinophilia. Contrast-enhanced CT revealed stenosis with thickening of the distal intestinal wall and partial intestinal obstruction. Colonoscopy found aphthous ulcers. Histopathology reported EE. The patient received budesonide and metronidazole, with resolution within 24 h.

https://doi.org/10.24875/ciru.21000723

13.

The COVID-19 pandemic’s risk factors for depression among postgraduate healthcare students
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Souza, Fernanda Rocha Anjos de Oliveira

; Nascimento, Vagner Ferreira do

; Espinosa, Mariano Martinez

; Pillon, Sandra Cristina

; Wagstaff, Chris

; Trettel, Ana Cláudia Pereira Terças

Salud mental

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aug 2023, Volume 46 N. 4 Pages 211 - 220

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción La pandemia ha generado desafíos que impactan en la salud mental de la población, incluidos los estudiantes de posgrado en salud. Objetivo Evaluar los factores asociados a la depresión en estudiantes de posgrado en salud durante la pandemia de COVID-19. Método Se trata de un estudio transversal con estudiantes de posgrado en salud, con una muestra de 117 participantes. Los datos fueron recolectados a través de un formulario en línea, entre septiembre y noviembre de 2021, utilizando cuestionarios semiestructurados con información sociodemográfica e información sobre la salud mental de los participantes, según lo definido por la Escala DSM-5, donde el dominio depresión fue considerado una variable para este estudiar. Las variables se probaron mediante el modelo de regresión múltiple de Poisson con varianza robusta en el análisis bivariado entre las variables dependientes e independientes (IC 95%). Resultados En el análisis bivariado, hubo asociación entre la depresión y no tener pareja, también una baja renta mensual, estudiar maestría o doctorado profesional y tener una relación laboral paralela al posgrado. En cuanto a la salud mental de los participantes, los siguientes factores se asociaron a la depresión: ira, manía, ansiedad, síntomas somáticos, ideación suicida, trastorno mental, memoria, pensamiento repetitivo, disociación, funcionamiento de la personalidad y uso de sustancias (p < .05). En el análisis múltiple se constató que la manía, la ansiedad y la disociación permanecieron estadísticamente asociadas a la depresión (p < .05). Discusión y conclusión Los factores asociados a la depresión en esta población elevan la importancia de las intervenciones de promoción de la salud mental para los estudiantes de posgrado en salud, quienes buscan ayuda tanto a través de los servicios de salud mental como a través de sus universidades.

Abstract Introduction The pandemic has generated challenges which impact the mental health of the population, including postgraduate healthcare students. Objective To evaluate the factors associated with depression in postgraduate healthcare students during the COVID-19 pandemic. Method This is a cross-sectional study with postgraduate healthcare students, with a sample of 117 participants. The data were collected through an online form, between September and November 2021, using semi-structured questionnaires with sociodemographic information and information regarding participants’ mental health, as defined by the DSM-5 Scale, where the depression domain was considered a variable for this study. The variables were tested using the Poisson multiple regression model with robust variance in the bivariate analysis between the dependent and independent variables (95% CI). Results In the bivariate analysis, there was an association between depression and not having a partner, also a low monthly income, studying for a master’s or professional doctorate and having an employment relationship parallel to the postgraduate course. Regarding the mental health of the participants, the following factors were associated with depression: anger, mania, anxiety, somatic symptoms, suicidal ideation, mental disorder, memory, repetitive thinking, dissociation, personality functioning, and substance use (p < .05). In the multiple analysis, it was found that mania, anxiety, and dissociation remained statistically associated with depression (p < .05). Discussion and conclusion Factors associated with depression in this population raise the importance of mental health promotion interventions for postgraduate healthcare students, who seek help both through mental health services and through their universities.

https://doi.org/10.17711/sm.0185-3325.2023.026

14.

In vitro cytotoxicity of resin cement and its influence on the expression of antioxidant genes
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Moralez, Priscila FA

; Kantovitz, Kamila R

; Martinez, Elizabeth F

; Teixeira, Lucas N

; Demasi, Ana PD

Acta Odontológica Latinoamericana

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aug 2023, Volume 36 N. 2 Pages 120 - 127

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: O objetivo deste estudo foi avaliar a toxicidade dos cimentos resinosos Rely X Ultimate 2, Rely X U200 e Variolink II, bem como sua influência na expressão de genes antioxidantes em fibroblastos gengivais humanos. Materiais e Método: Corpos de prova de cada cimento foram colocados em meio de cultura por 24 h e os extratos correspondentes foram aplicados aos fibroblastos. A viabilidade celular foi avaliada após 24, 48 e 72 h de exposição pelo ensaio de exclusão do azul de tripano e MTT. A expressão gênica foi avaliada por PCR quantitativo após 24 h de exposição aos extratos. Estes parâmetros foram comparados aos das células não expostas aos cimentos. Os dados foram submetidos ao teste ANOVA, seguido pelo pós-teste de Bonferroni (a≤0.05). Resultados: Os resultados demonstraram que todos os cimentos promoveram redução do número de células viáveis e da atividade mitocondrial nos períodos de 48 e de 72 h (p < 0,01), sendo que o Variolink II apresentou o menor efeito e os cimentos Rely X Ultimate e Rely X U200 promoveram similarmente os maiores efeitos. A análise de expressão gênica evidenciou influência significativa em todos os cimentos avaliados sobre os níveis de transcritos de PRDX1, SOD1, GPX1 e GSS (p> 0,05), com um aumento considerável no Rely X U200. Conclusão: A indução de genes antioxidantes está, pelo menos em parte, associada à citotoxicidade dos cimentos testados para a experiência de estresse oxidativo.

ABSTRACT Aim: This study evaluated cytotoxicity and antioxidant gene expression of resin cements on human gingival fibroblasts (hGF). Materials and Method: RelyX Ultimate™(RXU), Variolink™II(VLII), and RelyXU200™(RXU200) resin cements were incubated with culture medium for 24 h to obtain eluates. Then, the eluates were applied over hGF to assess cell viability at 24 h, 48 h, and 72 h and antioxidant gene expression at 24 h. hGF cultures non-exposed to the eluates were used as Control. Data were submitted to ANOVA and Bonferroni tests (α≤0.05). Results: RXU and RXU200 reduced the number of viable cells in 24 h. Longer exposure to cement extracts caused cell death. Gene expression showed peroxiredoxin 1 (PRDX1) induction by all resin cement types, and superoxide dismutase 1 (SOD1) induction by RXU200 and VLII. Moreover, RXU200 induced not only PRDX1 and SOD1, but also glutathione peroxidase 1 (GPX1), catalase (CAT), and glutathione synthetase (GSS). Conclusions: All resin cements showed toxicity, and induced antioxidant genes in hGF. Antioxidant gene induction is at least partly associated with cytotoxicity of tested cements to oxidative stress experience.

https://doi.org/10.54589/aol.36/2/120

15.

Efecto del sedentarismo sobre la interacción entre el gen FTO y niveles de adiposidad en adultos chilenos - Resultados del Estudio GENADIO
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Celis-Morales, Carlos

; Villagrán, Marcelo

; Mardones, Lorena

; Martínez-Sanguinetti, María Adela

; Leiva-Ordoñez, Ana María

; Carrasco-Marín, Fernanda

; Ulloa, Natalia

; Martorell, Miquel

; Lasserre-Laso, Nicole

; Díaz-Martinez, Ximena

; Cigarroa, Igor

; Concha-Cisternas, Yeny

; Troncoso-Pantoja, Claudia

; Lanuza, Fabian

; Vásquez-Gómez, Jaime

; Parra-Soto, Solange

; Petermann-Rocha, Fanny

Revista médica de Chile

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aug 2023, Volume 151 N. 8 Pages 980 - 991

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Background: The Fat-mass and obesity-associated-gene (FTO gene) and sedentary behavior time are associated with obesity. However, whether sedentary behavior time can modify the genetic predisposition to obesity in the Chilean population is unknown. Therefore, this study investigated the association between sedentary behavior, adiposity markers, and the FTO gene. Methods: This cross-sectional study included 409 participants from the Genes, Environment, Diabetes, and Obesity (GENADIO) study. Adiposity markers studied included body weight, body mass index (BMI), waist circumference (WC), and fat mass. Sedentary behaviors were measured using accelerometers. Using multiple regression, we evaluated the interaction between sedentary behaviors and the FTO gene (rs9939609) on adiposity markers. Results: Sedentary behaviors and the FTO genotype were positively associated with higher body weight, BMI, WC, and fat mass. However, the association between time of sedentary behavior and adiposity markers was higher in carriers of the risk variant for the FTO gene. For each hour of increment in sedentary behaviors, body weight increases by 1.36 kg ([95% CI: 0.27; 2.46], p = 0.015) and 2.95 kg ([95%CI: 1.24; 4.65], p = 0.001) in non-risk carriers (TT) versus risk carriers (AA), respectively. We observed similar results for WC, BMI, and body fat, but the interaction was significant only for WC. Conclusion: The association between sedentary behaviors and adiposity markers, especially body weight and WC, is higher in individuals who carry the risk variant of the FTO gene.

RESUMEN Antecedentes: Tanto el gen FTO (Fat-mass and obesity-associated-gene) y el tiempo sedente se asocian a obesidad, sin embargo, se desconoce si el tiempo sedente puede modificar la predisposición genética a la obesidad. Por ende, el objetivo de este estudio fue investigar si la asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad podrían ser modificados por el tiempo sedente. Métodos: Este estudio de corte transversal incluye a 409 participantes del estudio GENADIO. Los marcadores de adiposidad estudiados fueron peso corporal, índice de masa corporal (IMC), perímetro de cintura (PC) y porcentaje masa grasa. El tiempo sedente se determinó mediante acelerometría de movimiento. La interacción entre el gen FTO (rs9939609) y el tiempo sedente sobre los marcadores de adiposidad se determinó mediante análisis de regresión múltiple. Resultados: Tanto la variante de riesgo del gen FTO como el tiempo sedente se asociaron a mayor peso corporal, IMC, PC y masa grasa. Sin embargo, la asociación entre tiempo sedente y marcadores de adiposidad fue mayor en personas portadoras del alelo de riesgo del gen FTO. Por cada 1 hora de incremento en tiempo sedente, el peso corporal incrementa en 1,36 kg ([95% IC: 0,27; 2,46], p = 0,015) y 2,95 kg ([95% IC: 1,24; 4,65], p = 0,001) en personas con la variante protectora (TT) versus aquellos con la variante de riesgo (AA), respectivamente. Resultados similares se encontraron para (PC). Conclusión: La asociación entre la variante de riesgo de FTO y mayor nivel de adiposidad es más acentuada en individuos que presentan mayores niveles de sedentarismo.

https://doi.org/10.4067/s0034-98872023000800980

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