SUMMARY: This study aimed to explore the potential of Nasturtium officinale L. leaves extract (NOLE) in safeguarding hepatocytes against N-diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) by investigating its effects on biochemical, molecular, and antioxidant pathways. The study also delved into NOLE's role in modulating the HOTAIR/miR-124/Notch1 axis pathway. In this study, 50 Wistar rats were divided into five groups (n=10/group): normal, HCC-induced (100 mg/kg DEN), HCC rats treated with 100 and 200 mg/kg DEN + NOLE, and normal rats treated with 200 mg/kg NOLE. At the study's conclusion, serum levels of liver function markers (such as albumin, total protein, bilirubin, C-reactive protein, ALT, AST, and ALP), inflammatory cytokines (IL-6, IL- 1b, IL-10, and TNF-a), and oxidative parameters [including glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) enzyme activity, and nitric oxide (NO) levels] were assessed. The levels of HOTAIR, miR-124, Notch1, and Jagged1 genes and proteins in liver tissue were measured. Immunohistochemical analysis was used to evaluate P53-positive cells in liver hepatocytes. DEN administration led to significant alterations in body and liver weight, serum liver enzymes, antioxidant levels, inflammatory markers, and expression of genes/proteins related to the HOTAIR/miR-124/Notch1 axis in liver pathways. NOLE exhibited dose-dependent effects in mitigating these changes, notably enhancing weight, liver health, antioxidant capacity, and inflammatory responses, especially at the 200 mg/kg dosage. Histopathological assessments revealed structural improvements in liver tissue with NOLE treatment. In conclusion, our study highlights the potential of NOLE in exerting anti-cancer effects against DEN-induced HCC.

RESUMEN: Este estudio tuvo como objetivo explorar el potencial del extracto de hojas de Nasturtium officinale L. (NOLE) para proteger los hepatocitos contra el carcinoma hepatocelular (HCC) inducido por N-dietilnitrosamina (DEN) mediante la investigación de sus efectos sobre las vías bioquímicas, moleculares y antioxidantes. El estudio también profundizó en el papel de NOLE en la modulación de la vía del eje HOTAIR/miR-124/Notch1. En este estudio, 50 ratas Wistar se dividieron en cinco grupos (n=10/ grupo): ratas normales, inducidas por HCC (100 mg/kg de DEN), ratas con HCC tratadas con 100 y 200 mg/kg de DEN + NOLE y ratas normales tratadas con 200 mg/kg de NOLE. Al concluir el estudio, se midieron los niveles séricos de marcadores de función hepática (como albúmina, proteína total, bilirrubina, proteína C reactiva, ALT, AST y ALP), citoquinas inflamatorias (IL-6, IL-1β, IL-10 y TNF-α) y parámetros oxidativos [incluidos los niveles de glutatión peroxidasa (GPx), superóxido dismutasa (SOD), catalasa (CAT) y óxido nítrico (NO)]. Se midieron los niveles de los genes y proteínas HOTAIR, miR-124, Notch1 y Jagged1 en el tejido hepático. Se utilizó análisis inmunohistoquímico para evaluar las células P53 positivas en los hepatocitos del hígado. La administración de DEN provocó alteraciones significativas en el peso corporal y hepático, las enzimas hepáticas séricas, los niveles de antioxidantes, los marcadores inflamatorios y la expresión de genes/proteínas relacionadas con el eje HOTAIR/miR-124/Notch1 en las vías hepáticas. NOLE exhibió efectos dependientes de la dosis para mitigar estos cambios, en particular mejorando el peso, la salud del hígado, la capacidad antioxidante y las respuestas inflamatorias, especialmente en la dosis de 200 mg/kg. Las evaluaciones histopatológicas revelaron mejoras estructurales en el tejido hepático con el tratamiento NOLE. En conclusión, nuestro estudio destaca el potencial de NOLE para ejercer efectos anticancerígenos contra el CHC inducido por DEN.

More attention has been paid to immunotherapy for ovarian cancer and the development of tumor vaccines. We developed a trichostatin A (TSA)-modified tumor vaccine with potent immunomodulating activities that can inhibit the growth of ovarian cancer in rats and stimulate immune cell response in vivo. TSA-treated Nutu-19 cells inactivated by X-ray radiation were used as a tumor vaccine in rat ovarian cancer models. Prophylactic and therapeutic experiments were performed with TSA-modified tumor vaccine in rats. Flow cytometry and ELISpot assays were conducted to assess immune response. Immune cell expression in the spleen and thymus were detected by immunohistochemical staining. GM-CSF, IL-7, IL-17, LIF, LIX, KC, MCP-1, MIP-2, M-CSF, IP-10/CXCL10, MIG/CXCL9, RANTES, IL-4, IFN-γ, and VEGF expressions were detected with Milliplex Map Magnetic Bead Panel immunoassay. TSA vaccination in therapeutic and prophylactic models could effectively stimulate innate immunity and boost the adaptive humoral and cell-mediated immune responses to inhibit the growth and tumorigenesis of ovarian cancer. This vaccine stimulated the thymus into reactivating status and enhanced infiltrating lymphocytes in tumor-bearing rats. The expression of key immunoregulatory factors were upregulated in the vaccine group. The intensities of infiltrating CD4+ and CD8+ T cells and NK cells were significantly increased in the vaccine group compared to the control group (P<0.05). This protection was mainly dependent on the IFN-γ pathway and, to a much lesser extent, by the IL-4 pathway. The tumor cells only irradiated by X-ray as the control group still showed a slight immune effect, indicating that irradiated cells may also cause certain immune antigen exposure, but the efficacy was not as significant as that of the TSA-modified tumor vaccine. Our study revealed the potential application of the TSA-modified tumor vaccine as a novel tumor vaccine against tumor refractoriness and growth. These findings offer a better understanding of the immunomodulatory effects of the vaccine against latent tumorigenesis and progression. This tumor vaccine therapy may increase antigen exposure, synergistically activate the immune system, and ultimately improve remission rates. A vaccine strategy designed to induce effective tumor immune response is being considered for cancer immunotherapy. vaccines TSAmodified modified vivo TSAtreated treated Nutu19 Nutu 19 Nutu-1 Xray X ray staining GMCSF, GMCSF GM CSF, CSF GM-CSF IL7, IL7 IL 7, 7 IL-7 IL17, IL17 17, 17 IL-17 LIF LIX KC MCP1, MCP1 MCP 1, 1 MCP-1 MIP2, MIP2 MIP 2, 2 MIP-2 MCSF, MCSF M M-CSF IP10/CXCL10, IP10CXCL10 IPCXCL IP 10/CXCL10, 10 CXCL10 CXCL IP-10/CXCL10 MIGCXCL9 MIGCXCL MIG CXCL9 MIG/CXCL9 RANTES IL4, IL4 4, 4 IFNγ, IFNγ IFN γ, γ immunoassay cellmediated mediated tumorbearing bearing CD4 CD CD8 P<0.05. P005 P P<0.05 . 0 05 (P<0.05) extent IL- effect exposure progression system rates Nutu1 Nutu- IL1 IL-1 MCP- MIP- IP10 IP10/CXCL10 IP10CXCL1 10CXCL10 10/CXCL10 CXCL1 IP-10/CXCL1 MIG/CXCL P00 P<0.0 (P<0.05 IP1 IP10/CXCL1 IP10CXCL 10CXCL1 10/CXCL1 IP-10/CXCL P0 P<0. (P<0.0 IP10/CXCL 10CXCL 10/CXCL P<0 (P<0. P< (P<0 (P< (P

Abstract We aimed to develop a prognostic model for primary pontine hemorrhage (PPH) patients and validate the predictive value of the model for a good prognosis at 90 days. A total of 254 PPH patients were included for screening of the independent predictors of prognosis, and data were analyzed by univariate and multivariable logistic regression tests. The cases were then divided into training cohort (n=219) and validation cohort (n=35) based on the two centers. A nomogram was developed using independent predictors from the training cohort to predict the 90-day good outcome and was validated from the validation cohort. Glasgow Coma Scale score, normalized pixels (used to describe bleeding volume), and mechanical ventilation were significant predictors of a good outcome of PPH at 90 days in the training cohort (all P<0.05). The U test showed no statistical difference (P=0.892) between the training cohort and the validation cohort, suggesting the model fitted well. The new model showed good discrimination (area under the curve=0.833). The decision curve analysis of the nomogram of the training cohort indicated a great net benefit. The PPH nomogram comprising the Glasgow Coma Scale score, normalized pixels, and mechanical ventilation may facilitate predicting a 90-day good outcome. (PPH 9 25 tests n=219 n219 n 219 (n=219 n=35 n35 35 (n=35 centers 90day day score used volume, volume , volume) all P<0.05. P005 P P<0.05 . 0 05 P<0.05) P=0.892 P0892 892 (P=0.892 well area curve=0.833. curve0833 curve=0.833 833 curve=0.833) benefit 2 n=21 n21 21 (n=21 n=3 n3 3 (n=3 P00 P<0.0 P=0.89 P089 89 (P=0.89 curve083 curve=0.83 83 n=2 n2 (n=2 n= (n= P0 P<0. P=0.8 P08 8 (P=0.8 curve08 curve=0.8 (n P<0 P=0. (P=0. curve0 curve=0. P< P=0 (P=0 curve=0 P= (P= curve= (P

Abstract Objective MicroRNA-29a-3p has been reported in a variety of cancers, but its role in hypopharyngeal cancer remains unclear. This study was to determine the role of microRNA-29a-3p in the occurrence and development of hypopharyngeal cancer. Methods 40 patients with hypopharyngeal cancer who underwent surgery in the Affiliated Hospital of Jining Medical University from April 2013 to November 2017 were selected for this study. The cancer tissue samples of the patients were collected, and the patients were followed up for three years. The expression of microRNA-29a-3p in tissue samples was detected by in situ hybridization with fluorescent probe, and the relationships among microRNA-29a-3p and clinicopathological factors, postoperative recurrent-metastasis, survival time were studied. Immunohistochemical was used to detect the expression of Ki67 and E-cadherin in tissue samples. Results Combined with HE staining results showed that microRNA-29a-3p expression was relatively high in non-cancer tissue cells (red blood cells and fibroblasts in tumor interstitial vessels), but was relatively low in cancer tissue and cells. According to the follow-up data of 40 patients with hypopharyngeal cancer, tumor size, T-stage, tumor differentiation, postoperative recurrent-metastasis of hypopharyngeal cancer patients were significantly negatively correlated with microRNA-29a-3p (p< 0.05). Immunohistochemica results further confirmed that microRNA-29a-3p was negatively correlated with the expression of Ki67 and E-cadherin. The survival time of patients positively related with microRNA-29a-3p expression (p< 0.05). Moreover, ROC curve analysis showed that the area under the curve of the combined detection of miRNA-29a-3p+Ki67+E-cadherin was larger than that of the single detection of the three indexes. Conclusions The expression of microRNA-29a-3p is closely related to the occurrence, development and prognosis of hypopharyngeal cancer, and it affects the proliferation and invasion. This indicates that microRNA-29a-3p serves as a therapeutic target for the occurrence and development of hypopharyngeal cancer. The evidence of study designs of this study is IV using “Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence”. MicroRNA29a3p MicroRNAap MicroRNA 29a 3p p cancers unclear microRNA29a3p microRNAap microRNA 4 201 collected years probe factors recurrentmetastasis, recurrentmetastasis recurrent metastasis, metastasis studied Ki Ki6 Ecadherin E cadherin noncancer non red vessels, vessels , vessels) followup follow size Tstage, Tstage T stage, stage T-stage differentiation p< (p 0.05. 005 0.05 . 0 05 0.05) Ecadherin. cadherin. Moreover miRNA29a3p+Ki67+Ecadherin miRNA29a3pKi67Ecadherin miRNAapKiEcadherin miRNA 3p+Ki67+E indexes invasion Oxford EvidenceBased Evidence Based Evidence. Evidence” 20 00 0.0 miRNA29a3p pKi 3pKi67E pKiE 2 0. miRNAap

Résumé: L’image du “Dragon baignant le prince” est un thème important dans l’art bouddhique. L’image est née en Inde, et pendant le processus de propagation du bouddhisme vers l’est, elle est apparue dans le Xinjiang, le Gansu, le Qinghai, le Shanxi, le Shaanxi, le Henan, le Shandong, le Jiangsu, le Sichuan, le Tibet et d’autres endroits en Chine. Cependant, la forme et le contenu de ces images sont différents selon les régions et les périodes. L’étude de cette différence est non seulement propice à la compréhension du processus de sinisation de l’art bouddhiste indien, mais approfondit également la compréhension du contenu spécifique de l’échange de l’art bouddhiste l’art entre la Chine et l’Inde. Résumé Limage L image Dragon prince lart l art bouddhique Inde lest, lest est, l’est Xinjiang Gansu Qinghai Shanxi Shaanxi Henan Shandong Jiangsu Sichuan dautres d autres Cependant périodes Létude étude indien léchange échange lInde. lInde Inde. l’Inde

Abstract: The image of the “Nagas Bathing Siddhartha”, an important theme in Buddhist art, was produced in India and has appeared successively in Xinjiang, Gansu, Qinghai, Shanxi, Shaanxi, Henan, Shandong, Jiangsu, Sichuan, Tibet and other places in China during the process of Buddhism spreading to the east. However, its forms and contents differ in different regions and different periods. Therefore, it is conducive to understand the sinicization process of Indian Buddhist art and can deepen the understanding of the specific contents of Buddhist art exchanges to study the differences. The innovative point of view of this paper is that the distribution of “Nagas Bathing Siddhartha” is “regional,” and the variation of its style reflects the route and regional characteristics of Buddhist transmission. Abstract Nagas Siddhartha, Siddhartha , Xinjiang Gansu Qinghai Shanxi Shaanxi Henan Shandong Jiangsu Sichuan east However periods Therefore differences regional, “regional, transmission “regional

RESUMEN Introducción: El buen rendimiento de los estudiantes universitarios depende directamente de su integridad física, que está subordinada a una buena forma física y resistencia cardiopulmonar. Se cree que el entrenamiento aeróbico, una adaptación al aumento progresivo de la resistencia física, puede aportar beneficios a los estudiantes universitarios. Objetivo: Estudiar si la práctica del entrenamiento aeróbico puede afectar a la forma física y a la resistencia cardiopulmonar de los estudiantes universitarios. Métodos: Mediante comparación experimental, se compararon la forma física y la resistencia cardiopulmonar de los estudiantes de la clase optativa de aeróbic y de la clase optativa de atletismo universitario. Se midieron los índices corporales antes y después de la intervención, se trabajaron estadísticamente y se discutieron según la bibliografía. Resultados: Hubo cambios significativos en el tiempo de carrera de 50 metros de los estudiantes universitarios de la clase electiva de aeróbic, de 9,24±1,71 a 7,81±2,02, la carrera de cinco metros fue de 11,56±1,03 a 7,87±0,23, el salto de pie fue de 156,92±14,79 a 170,56±19,93, y la flexión en posición sentada de 14,07±1,98 a 17,52±3,79. Estos cambios acompañaron a los cambios de la resistencia cardiorrespiratoria en la clase optativa de aeróbic, mientras que los cambios de los indicadores en los alumnos de la clase optativa de atletismo no fueron tan evidentes. Conclusión: El entrenamiento aeróbico mostró un impacto positivo en la calidad física general, incluyendo la elevación de los índices de condición física y resistencia cardiopulmonar en estudiantes universitarios. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción Objetivo Métodos experimental universitario intervención bibliografía Resultados 5 924171 9 24 1 71 9,24±1,7 781202 7 81 2 02 7,81±2,02 1156103 11 56 03 11,56±1,0 787023 87 0 23 7,87±0,23 156921479 156 92 14 79 156,92±14,7 170561993 170 19 93 170,56±19,93 1407198 07 98 14,07±1,9 1752379 17 52 3 17,52±3,79 evidentes Conclusión general II tratamiento 92417 9,24±1, 78120 8 7,81±2,0 115610 11,56±1, 78702 7,87±0,2 15692147 15 156,92±14, 17056199 170,56±19,9 140719 14,07±1, 175237 17,52±3,7 9241 9,24±1 7812 7,81±2, 11561 11,56±1 7870 7,87±0, 1569214 156,92±14 1705619 170,56±19, 14071 14,07±1 17523 17,52±3, 924 9,24± 781 7,81±2 1156 11,56± 787 7,87±0 156921 156,92±1 170561 170,56±19 1407 14,07± 1752 17,52±3 9,24 78 7,81± 115 11,56 7,87± 15692 156,92± 17056 170,56±1 140 14,07 175 17,52± 9,2 7,81 11,5 7,87 1569 156,92 1705 170,56± 14,0 17,52 9, 7,8 11, 156,9 170,56 14, 17,5 7, 156, 170,5 17, 170,

RESUMO Introdução: O bom desempenho dos estudantes universitários depende diretamente de sua integridade física, que está subordinada a uma boa aptidão física e resistência cardiopulmonar. Acredita-se que o treinamento aeróbico, uma adaptação ao aumento progressivo da resistência física, possa trazer benefícios aos estudantes universitários. Objetivo: Estudar se a prática do treinamento aeróbico pode afetar a aptidão física e a resistência cardiopulmonar dos estudantes universitários. Métodos: Através de comparação experimental, a aptidão física e a resistência cardiopulmonar dos alunos da classe optativa de aeróbica e da classe optativa de atletismo universitário foram comparadas. Os índices corporais foram mensurados antes e após a intervenção, trabalhados estatisticamente e discutidos conforme a literatura. Resultados: Houveram alterações significativas no tempo de corrida 50 metros pelos estudantes universitários da classe eletiva de aeróbica, de 9,24±1,71 para 7,81±2,02, a de cinco metros foi de 11,56±1,03 para 7,87±0,23, o salto em pé foi de 156,92±14,79 para 170,56±19,93, e a flexão em posição sentada de 14,07±1,98 para 17,52±3,79. Essas alterações acompanharam as mudanças de resistência cardiorrespiratória na classe eletiva de aeróbica, enquanto as mudanças dos indicadores em alunos na classe eletiva de atletismo não foram tão evidentes. Conclusão: O treinamento em aeróbico mostrou um impacto positivo sobre a qualidade física geral, incluindo elevação dos índices de aptidão física e da resistência cardiopulmonar nos estudantes universitários. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução Acreditase Acredita Objetivo Métodos experimental comparadas intervenção literatura Resultados 5 924171 9 24 1 71 9,24±1,7 781202 7 81 2 02 7,81±2,02 1156103 11 56 03 11,56±1,0 787023 87 0 23 7,87±0,23 156921479 156 92 14 79 156,92±14,7 170561993 170 19 93 170,56±19,93 1407198 07 98 14,07±1,9 1752379 17 52 3 17,52±3,79 evidentes Conclusão geral II tratamento 92417 9,24±1, 78120 8 7,81±2,0 115610 11,56±1, 78702 7,87±0,2 15692147 15 156,92±14, 17056199 170,56±19,9 140719 14,07±1, 175237 17,52±3,7 9241 9,24±1 7812 7,81±2, 11561 11,56±1 7870 7,87±0, 1569214 156,92±14 1705619 170,56±19, 14071 14,07±1 17523 17,52±3, 924 9,24± 781 7,81±2 1156 11,56± 787 7,87±0 156921 156,92±1 170561 170,56±19 1407 14,07± 1752 17,52±3 9,24 78 7,81± 115 11,56 7,87± 15692 156,92± 17056 170,56±1 140 14,07 175 17,52± 9,2 7,81 11,5 7,87 1569 156,92 1705 170,56± 14,0 17,52 9, 7,8 11, 156,9 170,56 14, 17,5 7, 156, 170,5 17, 170,

ABSTRACT Introduction: The good performance of college students depends directly on their physical integrity, which is subordinated to good physical fitness and cardiopulmonary resistance. It is believed that aerobic training, an adaptation to the progressive increase of physical endurance, may benefit college students. Objective: Study whether aerobic training can affect college students’ physical fitness and cardiopulmonary endurance. Methods: Through experimental comparison, the physical fitness and cardiopulmonary endurance of students in the aerobics elective class and the university athletics elective class were compared. Body indexes were measured before and after the intervention, statistically analyzed, and discussed according to the literature. Results: There were significant changes in the 50-meter run time for university students in the elective aerobics class from 9.24±1.71 to 7.81±2.02, the five-meter run from 11.56±1.03 to 7.87±0.23, the standing jump from 156.92±14.79 to 170.56±19.93, and the sitting flexion from 14.07±1.98 to 17.52±3.79. These changes accompanied the changes in cardiorespiratory endurance in the aerobics elective class. In contrast, the changes in student indicators in the track and field elective class were not as evident. Conclusion: Aerobic training positively impacted overall physical quality, including elevation of fitness indices and cardiopulmonary endurance in college students. Level of evidence II; Therapeutic studies - investigation of treatment outcomes. Introduction integrity resistance Objective Methods comparison compared intervention analyzed literature Results 50meter meter 50 924171 9 24 1 71 9.24±1.7 781202 7 81 2 02 7.81±2.02 fivemeter five 1156103 11 56 03 11.56±1.0 787023 87 0 23 7.87±0.23 156921479 156 92 14 79 156.92±14.7 170561993 170 19 93 170.56±19.93 1407198 07 98 14.07±1.9 1752379 17 52 3 17.52±3.79 contrast evident Conclusion quality II outcomes 5 92417 9.24±1. 78120 8 7.81±2.0 115610 11.56±1. 78702 7.87±0.2 15692147 15 156.92±14. 17056199 170.56±19.9 140719 14.07±1. 175237 17.52±3.7 9241 9.24±1 7812 7.81±2. 11561 11.56±1 7870 7.87±0. 1569214 156.92±14 1705619 170.56±19. 14071 14.07±1 17523 17.52±3. 924 9.24± 781 7.81±2 1156 11.56± 787 7.87±0 156921 156.92±1 170561 170.56±19 1407 14.07± 1752 17.52±3 9.24 78 7.81± 115 11.56 7.87± 15692 156.92± 17056 170.56±1 140 14.07 175 17.52± 9.2 7.81 11.5 7.87 1569 156.92 1705 170.56± 14.0 17.52 9. 7.8 11. 156.9 170.56 14. 17.5 7. 156. 170.5 17. 170.

RESUMO Este trabalho teve como objetivo desenvolver um método para tratar e reutilizar efluentes industriais organofosforados não biodegradáveis usando o reator de microcanal. Como um importante intermediário farmacêutico e químico fino, o dietil hidroximetilfosfonato (DHP) produz grandes quantidades de efluentes industriais, o que representa uma séria ameaça ao ambiente natural e à saúde humana. É de grande valia encontrar um método de tratamento de efluentes industriais DHP com operação simples, boa segurança, baixo custo e ecologicamente correto. Neste estudo, o peróxido de hidrogênio e o efluente industrial DHP foram reagidos no reator de microcanal. As condições de reação foram otimizadas ajustando-se a temperatura de reação, o tempo de reação, a pressão de reação e a taxa de fluxo de amostragem. O efluente tratado foi posteriormente neutralizado por hidróxido de sódio. Após a reação de oxidação e neutralização das águas residuais industriais DHP, a taxa de remoção da demanda química de oxigênio nas águas residuais de tratamento pode chegar a 97,3%. Além disso, depois da secagem da solução tratada, o fosfato inorgânico sólido foi obtido com teor de fósforo tão alto quanto 92,1%. Pode-se reutilizar recursos de fósforo para as águas residuais industriais DHP. microcanal fino (DHP humana simples segurança correto estudo ajustandose ajustando se amostragem sódio 973 97 3 97,3% disso tratada 921 92 1 92,1% Podese Pode 9 97,3 92,1 97, 92,

ABSTRACT This study aimed to develop a method to treat and reuse non-biodegradable organophosphorus industrial wastewater using the micro-channel reactor. As an important pharmaceutical and fine chemical intermediate, diethyl hydroxymethylphosphonate (DHP) produces large amounts of industrial wastewater, which poses a serious threat to natural environment and human health. It is of great value to find a treatment method of the DHP industrial wastewater with simple operation, good safety, low cost, and environment friendly. In this study, hydrogen peroxide (H2O2) and DHP industrial wastewater were reacted in the micro-channel reactor. Reaction conditions were optimized by adjusting reaction temperature, reaction time, reaction pressure, and sampling flow rate. The treated wastewater was further neutralized by sodium hydroxide (NaOH). After the oxidation and neutralization reaction of the DHP industrial wastewater, the removal rate of chemical oxygen demand (COD) in treatment wastewater can reach 97.3%. Moreover, after the treated solution being dried, the inorganic phosphate solid was obtained with the phosphorus content as high as 92.1%. It can realize the reuse of phosphorus resources for the DHP industrial wastewater. nonbiodegradable non biodegradable microchannel micro channel reactor intermediate (DHP health operation safety cost friendly H2O2 HO H O (H2O2 temperature time pressure NaOH. NaOH . (NaOH) COD (COD 973 97 3 97.3% Moreover dried 921 92 1 92.1% H2O (H2O (NaOH 9 97.3 92.1 97. 92.

ABSTRACT Introduction: Remote ischemic preconditioning (RIPC) is a new noninvasive myocardial protection strategy that uses blood pressure cuf inflation to simulate transient non-fatal ischemia to protect the myocardium and reduce ischemia-reperfusion injury. Sulfonylureas may mask the effects of RIPC due to their cardioprotec-tive effect. This meta-analysis aimed to evaluate whether RIPC, in the absence of sulfonylureas, reduces troponin release in patients undergoing cardiac surgery. Methods: We conducted a meta-analysis of randomized controlled clinical trials to determine whether RIPC can reduce postoperative troponin release in cardiac surgery patients undergoing cardiopulmonary bypass without treatment with sulfonylureas. The data were normalized to equivalent units prior to the analysis. A random-effects model was used to provide more conservative estimate of the effects in the presence of known or unknown heterogeneity. Results: Six studies with a total of 570 participants were included. The analysis showed that troponin release was lower in the RIPC group than in the control group at six hours (test of standardized mean differences = 0, Z=3.64, P<0.001) and 48 hours (Z=2.72, P=0.007) postoperatively. When the mean of cross-clamping time was > 60 minutes, RIPC reduced troponin release at six hours (Z=2.84, P=0.005), 24 hours (Z=2.64, P=0.008), and 48 hours (Z=2.87, P=0.004) postoperatively. Conclusion: In cardiac surgery patients who are not taking sulfonylureas, RIPC can reduce troponin release at six and 48 hours postoperatively; hence, RIPC may serve significant benefits in certain cardiac surgery patients. Introduction (RIPC nonfatal non fatal ischemiareperfusion reperfusion injury cardioprotective cardioprotec tive effect metaanalysis meta sulfonylureas Methods randomeffects random heterogeneity Results 57 included test 0 Z364 Z 3 64 Z=3.64 P<0.001 P0001 P 001 4 Z=2.72, Z272 2 72 (Z=2.72 P=0.007 P0007 007 postoperatively crossclamping cross clamping 6 minutes Z=2.84, Z284 84 (Z=2.84 P=0.005, P0005 P=0.005 , 005 P=0.005) Z=2.64, Z264 (Z=2.64 P=0.008, P0008 P=0.008 008 P=0.008) Z=2.87, Z287 87 (Z=2.87 P=0.004 P0004 004 Conclusion hence 5 Z36 Z=3.6 P<0.00 P000 00 Z=2.72 Z27 7 (Z=2.7 P=0.00 Z=2.84 Z28 8 (Z=2.8 Z=2.64 Z26 (Z=2.6 Z=2.87 Z3 Z=3. P<0.0 P00 Z=2.7 Z2 (Z=2. P=0.0 Z=2.8 Z=2.6 Z=3 P<0. P0 Z=2. (Z=2 P=0. Z= P<0 Z=2 (Z= P=0 P< (Z P=

ABSTRACT Two-stage harvesting is the main method for performing the mechanized harvesting of peanuts, and the picking device is a core part of the combined harvester in China. In order to solve the problem of pod loss caused by the "stacking", "impact" and "throwing up" of peanut plants by a traditional cam-slide spring-finger cylinder picking device, the shovel-finger and cylinder peanut-picking device was developed and used in a picking-up performance test based on the study of peanut-plant strip-picking characteristics. The mathematical model of the mechanism was established by analyzing the structure of the mechanism and the peanut-plant strip-picking characteristics, and the parameters of the mechanism were optimized using the objective function method. The prototype was developed and tested. The experiments in which the prototype was used to collect peanut plants indicated that the phenomenon of peanut plants being stacked and thrown disappeared. Through a response surface analysis and prototype test, the optimal working parameters of the picking device were obtained: the forward speed V was 48.0 m/minute, the rotational speed N was 45.3 r/minute and the ground height H was -18 mm. The peanut-plant picking rate was 98.9% and the fruit loss rate was 2.8% under two different harvesting conditions for which the peanut-plant moisture content was 15~17%. Twostage Two stage peanuts China stacking, stacking , "stacking" impact "impact throwing up camslide cam slide springfinger spring finger shovelfinger shovel peanutpicking pickingup peanutplant plant strippicking strip characteristics tested disappeared obtained 480 48 0 48. mminute m minute m/minute 453 45 3 45. rminute r 18 -1 mm 989 98 9 98.9 28 2 8 2.8 1517 15 17 15~17% "stacking 4 1 - 98. 2. 151 15~17 15~1 15~

Abstract Using UPLC and PDA detector, the fingerprints of Dendrobium devonianum and Dendrobium officinale produced in the Longling area of Yunnan Province, China were obtained quickly and efficiently, and 26 common peaks in Dendrobium devonianum and Dendrobium officinale samples were obtained by automatic peak matching through the “Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System”. The relative peak areas of the common peaks were analyzed by PCA using R, and the results showed that Dendrobium devonianum and Dendrobium officinale could be well distinguished by PCA, which was consistent with the analysis results of OPLS-DA. The results fully demonstrate that Dendrobium devonianum and Dendrobium officinale grown in the same area can be effectively distinguished by using the method of common peaks combined with stoichiometry. The VIP value of the 13 common peaks is greater than 1.0, which has a significant contribution to the difference and it was differential marker in Dendrobium devonianum and Dendrobium officinale. At the same time, normal-phase silica gel column chromatography was used to separate and purify the compounds that are related to the common peaks, and a total of 7 compounds were identified, among which eupatolide and isoschaftoside belong to differential markers and characteristic compounds in Dendrobium devonianum and Dendrobium officinale, which have good biological health care activity. The successful identification of Dendrobium devonianum and Dendrobium officinale in Longling area of Yunnan Province and the discovery of related differential markers play an important role in the further research and development of Dendrobium devonianum as a new food raw material and its products. detector efficiently 2 Chinese System. System . System” R OPLSDA. OPLSDA OPLS DA. DA OPLS-DA stoichiometry 1 10 0 1.0 time normalphase normal phase identified activity products 1.

RESUMEN Introducción: El voleibol está constituido principalmente por actividades aeróbicas, causando impactos positivos en la resistencia cardiopulmonar y en la aptitud física de los estudiantes universitarios. Estudiar científicamente los impactos del entrenamiento de este deporte puede proporcionar una referencia científica en la que basar el entrenamiento de los alumnos. Objetivo: Estudiar los efectos del entrenamiento de voleibol sobre la aptitud física y la resistencia cardiopulmonar de estudiantes universitarios. Métodos: Para el experimento se seleccionaron aleatoriamente estudiantes de segundo curso de educación física de una universidad (n=50). Divididos en grupo experimental -que adoptó entrenamiento y práctica de voleibol- y control -con atletismo tradicional-, se sometieron a un semestre completo de actividades físicas dirigidas. Se realizaron pruebas de aptitud física y resistencia cardiopulmonar antes y después del experimento, se catalogaron los resultados de las baterías de pruebas y se confrontaron estadísticamente. Resultados: Los resultados de los alumnos de la clase experimental fueron superiores en las pruebas de aptitud física (P<0,05). La diferencia en el impacto sobre la resistencia cardiopulmonar final intergrupos no fue tan evidente, lo que demuestra que ambas intervenciones dieron lugar a un buen acondicionamiento. Conclusión: El entrenamiento de voleibol presentó impactos positivos sobre la aptitud física y la resistencia cardiopulmonar de los estudiantes universitarios. También aumentó el interés de los alumnos por el deporte, optimizando la calidad física de los universitarios y mejorando su resistencia cardiopulmonar. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción aeróbicas Objetivo Métodos n=50. n50 n n=50 . 50 (n=50) con tradicional, tradicional , tradicional- dirigidas estadísticamente Resultados P<0,05. P005 P P<0,05 0 05 (P<0,05) evidente acondicionamiento Conclusión II tratamiento n5 n=5 5 (n=50 P00 P<0,0 (P<0,05 n= (n=5 P0 P<0, (P<0,0 (n= P<0 (P<0, (n P< (P<0 (P< (P

RESUMO Introdução: O voleibol é constituído principalmente por atividades aeróbicas, causando impactos positivos sobre a resistência cardiopulmonar e aptidão física dos estudantes universitários. Estudar cientificamente os impactos do treinamento desse esporte pode fornecer uma referência científica para embasar o treinamento estudantil. Objetivo: Estudar os efeitos do treinamento de voleibol sobre a aptidão física e a resistência cardiopulmonar dos estudantes universitários. Métodos: Alunos do segundo ano de educação física em uma universidade foram selecionados aleatoriamente para o experimento (n=50). Divididos em grupo experimental – adotando treinamento e prática de voleibol e controle – com atletismo tradicional, foram submetidos a um semestre completo de atividades físicas direcionadas. Testes de aptidão física e resistência cardiopulmonar foram executados antes e após o experimento, os resultados das baterias de testes foram catalogados e confrontados estatisticamente. Resultados: Os resultados dos alunos da classe experimental foram superiores nas provas de aptidão física (P<0.05). A diferença no impacto sobre a resistência cardiopulmonar final inter-grupo não foi tão evidente, demonstrando que ambas intervenções acarretaram em um bom condicionamento. Conclusão: O treinamento de vôlei apresentou impactos positivos sobre a aptidão física e a resistência cardiopulmonar dos estudantes universitários. Também aumentou o interesse dos alunos pelo esporte, otimizando a qualidade física dos estudantes universitários e melhorando a sua resistência cardiopulmonar. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução aeróbicas estudantil Objetivo Métodos n=50. n50 n n=50 . 50 (n=50) tradicional direcionadas estatisticamente Resultados P<0.05. P005 P P<0.05 0 05 (P<0.05) intergrupo inter evidente condicionamento Conclusão II tratamento n5 n=5 5 (n=50 P00 P<0.0 (P<0.05 n= (n=5 P0 P<0. (P<0.0 (n= P<0 (P<0. (n P< (P<0 (P< (P

ABSTRACT Introduction: Volleyball consists mainly of aerobic activities, causing positive impacts on cardiopulmonary resistance and the physical fitness of college students. Studying scientifically the training impacts of this sport can provide a scientific reference to support student training. Objective: Study the effects of volleyball training on college students’ physical fitness and cardiopulmonary endurance. Methods: Second-year physical education students at a university were randomly selected for the experiment (n=50). Divided into the experimental group - adopting volleyball training and practice and control - with traditional athletics, they underwent a full semester of targeted physical activities. Physical fitness and cardiopulmonary endurance tests were performed before and after the experiment, and the results of the test batteries were cataloged and statistically confronted. Results: The experimental class students’ results were superior in the physical fitness tests(P<0.05). The difference in the impact on final inter-group cardiopulmonary resistance was not so evident, demonstrating that both interventions resulted in good conditioning. Conclusion: Volleyball training positively impacted college students’ physical fitness and cardiopulmonary endurance. It also increased the students’ interest in the sport, optimizing the college students’ physical quality and improving their cardiopulmonary resistance. Level of evidence II; Therapeutic studies - investigating treatment outcomes. Introduction activities Objective Methods Secondyear Second year n=50. n50 n n=50 . 50 (n=50) athletics confronted Results testsP<0.05. testsP005 testsP P<0.05 P 0 05 tests(P<0.05) intergroup inter evident conditioning Conclusion II outcomes n5 n=5 5 (n=50 testsP<0.05 testsP00 P005 P<0.0 tests(P<0.05 n= (n=5 testsP<0.0 testsP0 P00 P<0. tests(P<0.0 (n= testsP<0. P0 P<0 tests(P<0. (n testsP<0 P< tests(P<0 testsP< tests(P< tests(P

ABSTRACT Introduction: Remote ischemic preconditioning (RIPC) is a new noninvasive myocardial protection strategy that uses blood pressure cuf inflation to simulate transient non-fatal ischemia to protect the myocardium and reduce ischemia-reperfusion injury. Sulfonylureas may mask the effects of RIPC due to their cardioprotec-tive effect. This meta-analysis aimed to evaluate whether RIPC, in the absence of sulfonylureas, reduces troponin release in patients undergoing cardiac surgery. Methods: We conducted a meta-analysis of randomized controlled clinical trials to determine whether RIPC can reduce postoperative troponin release in cardiac surgery patients undergoing cardiopulmonary bypass without treatment with sulfonylureas. The data were normalized to equivalent units prior to the analysis. A random-effects model was used to provide more conservative estimate of the effects in the presence of known or unknown heterogeneity. Results: Six studies with a total of 570 participants were included. The analysis showed that troponin release was lower in the RIPC group than in the control group at six hours (test of standardized mean differences = 0, Z=3.64, P<0.001) and 48 hours (Z=2.72, P=0.007) postoperatively. When the mean of cross-clamping time was > 60 minutes, RIPC reduced troponin release at six hours (Z=2.84, P=0.005), 24 hours (Z=2.64, P=0.008), and 48 hours (Z=2.87, P=0.004) postoperatively. Conclusion: In cardiac surgery patients who are not taking sulfonylureas, RIPC can reduce troponin release at six and 48 hours postoperatively; hence, RIPC may serve significant benefits in certain cardiac surgery patients.

Abstract A chitosan-based edible coating was prepared by incorporating γ-polyglutamic acid and curcumin. The physical, mechanical and antimicrobial properties of the chitosan/γ-polyglutamic acid/curcumin edible coating were characterized. Furthermore, the effect of chitosan/γ-polyglutamic acid/curcumin edible coating on the shelf-life of fresh beef was investigated. The γ-polyglutamic acid and curcumin incorporation greatly improved the performance of chitosan coating, including coating formation and antimicrobial activity. After the application of coating, the chitosan/γ-polyglutamic acid/curcumin edible coating had a good protection effect on the color of beef and was conducive to prolonging the shelf life of beef with good quality compared to pure curcumin edible coating. These results revealed that application of chitosan/γ-polyglutamic acid/ curcumin edible coating will be a good way to preserve freshness of fresh beef.

RESUMO Introdução Métodos de exercício com postura incorreta ou movimentos repetitivos inadequados podem causar danos corporais irreversíveis à longo prazo. Há um crescente interesse sobre a ergonomia nas artes marciais porém o taekwondo carece de estudos. Objetivo Avaliar o impacto da ergonomia postural nas lesões e a reabilitação em atletas de taekwondo. Métodos 13 membros da equipe de taekwondo de uma academia esportiva tiveram suas posturas e características de lesão avaliadas. Usando método de pesquisa, experimental e estatística matemática, investigou-se os dados de diagnóstico postural e corporal dos esportistas confrontando as informações com o histórico de lesões, dor e tempo de lesão. Resultados Há 9 atletas que sofreram lesões e dores na cintura pélvica e articulações do tornozelo, as probabilidades são de 69,23%, as articulações da cintura pélvica e do tornozelo têm a maior frequência de lesões; seguida por lesões no joelho (46,15%), e as articulações dos pés (30,77%). Lesões nas coxas, articulações do pulso e ombros foram detectadas em 23,08% esportistas. Conclusões Os resultados deste estudo mostram que as disfunções posturais podem ser corrigidas com avaliação da função motora e a reabilitação precoce baseados na postura ergonômica do esporte. Nível de evidência II; Estudos Terapêuticos - Investigação de Resultados.

ABSTRACT Introduction Exercise methods with incorrect posture or inadequate repetitive movements may cause irreversible long-term body damage. There is a growing interest in ergonomics in martial arts, but taekwondo lacks studies. Objective Evaluate the postural ergonomics impact on injuries and rehabilitation in taekwondo athletes. Methods 13 taekwondo team members from a sports academy had their posture and injury characteristics evaluated. Research methods, experimental and mathematical statistics investigated the athletes’ postural and body diagnosis, confronting the information with their injury history, pain, and injury duration. Results Nine athletes suffered injuries and pain in the pelvic girdle and ankle joints; the odds are 69.23%, pelvic girdle and ankle joints have the highest frequency of injuries, followed by knee injuries (46.15%), and foot joints (30.77%). Injuries to the thigh, wrist, and shoulder joints were detected in 23.08% of athletes. Conclusions The results of this study indicate postural dysfunctions can be corrected with motor function evaluation and early rehabilitation based on ergonomic sports posture. Evidence Level II; Therapeutic Studies - Investigating the result.

RESUMEN Introducción Los métodos de ejercicio con posturas incorrectas o movimientos repetitivos inadecuados pueden causar daños corporales irreversibles a largo plazo. Existe un creciente interés por la ergonomía en las artes marciales, pero el taekwondo carece de estudios. Objetivo Evaluar el impacto de la ergonomía postural en las lesiones y en la rehabilitación de los atletas de taekwondo. Métodos Se evaluaron las posturas y las características de las lesiones de 13 miembros del equipo de taekwondo de una academia deportiva. Utilizando el método de investigación, experimental y estadística matemática, se investigaron los datos de diagnóstico postural y corporal de los atletas, confrontando la información con su historial de lesiones, el dolor y el tiempo de lesión. Resultados Hay 9 atletas que sufrieron lesiones y dolor en las articulaciones de la cintura pélvica y el tobillo, las probabilidades son del 69,23%, las articulaciones de la cintura pélvica y el tobillo tienen la mayor frecuencia de lesiones; seguidas de las lesiones de rodilla (46,15%), y las articulaciones del pie (30,77%). Se detectaron lesiones en las articulaciones del muslo, la muñeca y el hombro en el 23,08% de los atletas. Conclusiones Los resultados de este estudio muestran que las disfunciones posturales pueden corregirse con la evaluación de la función motora y la rehabilitación temprana basada en la postura deportiva ergonómica. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.

Resumen La cirugía desempeña un papel insustituible en la prevención, diagnóstico, estadificación, reconstrucción y rehabilitación en el tratamiento global del cáncer. Sin embargo, es difícil que cirujanos y personal de enfermería tengan en cuenta todos los aspectos de la gestión de la medicación, como el impacto de la cirugía en la función física del paciente y la complejidad del tratamiento antitumoral con sus comorbilidades. Los servicios de atención farmacéutica que anteriormente prestaban los farmacéuticos en oncología se centraban más en aspectos de la medicina interna, y no ampliamente en el ámbito quirúrgico. En la actualidad, el modo de trabajo farmacéutico en la cirugía oncológica aún no está definido en China, y existe una necesidad de mejorar la gestión de la medicación de todo el proceso asistencial. En 2015, la Asociación Farmacéutica de GuangDong propuso la creación del rol de farmacéutico quirúrgico en China y posteriormente creó su puesto de trabajo. En 2021, la Asociación Farmacéutica de GuangDong estableció una nueva disciplina denominada “farmacia quirúrgica”, que es el área de conocimiento de los farmacéuticos quirúrgicos, y también intentó diferenciar la farmacia quirúrgica en distintas subáreas, como la farmacia quirúrgica oncológica. Este artículo presenta el modo de trabajo de los farmacéuticos quirúrgicos en China, que proporciona servicios de atención farmacéutica en el periodo perioperatorio de los pacientes incorporando los distintos aspectos del tratamiento antitumoral, control de infecciones, anestesia, anticoagulación, control de la presión arterial y la glucosa en sangre, nutrición y tratamiento del dolor, con el objetivo de mejorar la calidad de vida de los pacientes.

Abstract Surgery plays an irreplaceable role in the prevention, diagnosis, staging, reconstruction, and rehabilitation in the overall management of cancer. Nevertheless, it is difficult for surgeons and nurses to take into account the details of medication management, considering the impact of surgery on the patient’s physical function and the complexity of anti-tumor treatment with comorbidity. The pharmaceutical care services previously provided by pharmacists in oncology focus more on the internal medicine system, not widely the surgical field. At present, the pharmaceutical working mode in oncology surgery has not well been formed around China, and the whole process medication management needs to be improved. In 2015, the GuangDong Pharmaceutical Association came up with the concept of surgical pharmacist in China and subsequently created its position. In 2021, the GuangDong Pharmaceutical Association established a new discipline termed “surgical pharmacy”, which is the knowledge system of surgical pharmacists, and also tried to differentiate surgical pharmacy into diverse areas, such as oncology surgical pharmacy. This article introduced a working mode of surgical pharmacists in China that providing pharmaceutical care services in perioperative period around anti-tumor, anti-infection, anesthesia, anticoagulation, blood pressure, blood glucose, nutrition, and pain management, to improve quality of life for patients.