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RESUMO Introdução: Doenças pulmonares são comuns em pacientes com doença renal em estágio terminal (DRET), dificultando o diagnóstico diferencial com COVID-19. Este estudo descreve achados de tomografia computadorizada de tórax (TC) em pacientes com DRET em terapia renal substitutiva (TRS) hospitalizados com suspeita de COVID-19. Métodos: Indivíduos maiores de 18 anos com DRET, encaminhados ao pronto-socorro com suspeita de COVID-19 foram incluídos. Dados clínicos e epidemiológicos foram extraídos de registros eletrônicos de saúde. A TC foi classificada como típica, indeterminada, atípica, negativa. Comparamos achados tomográficos de pacientes com COVID-19 positivos e negativos. Resultados: Recrutamos 109 pacientes (62,3% COVID-19-positivos) entre março e dezembro de 2020, idade média de 60 ± 12,5 anos, 43% mulheres. A etiologia mais comum da DRET foi diabetes. Tempo médio em diálise foi 36 meses, intervalo interquartil = 12–84. A lesão pulmonar mais comum foi opacidades em vidro fosco. O padrão típico de TC foi mais comum em pacientes com COVID-19 (40 (61%) vs. 0 (0%) em pacientes sem COVID-19, p < 0,001). Sensibilidade 60,61% (40/66), especificidade 100% (40/40). Valores preditivos positivos e negativos foram 100% e 62,3%, respectivamente. Padrão atípico de TC foi mais frequente em pacientes COVID-19-negativos (9 (14%) vs. 24 (56%) em COVID-19-positivos, p < 0,001), enquanto padrão indeterminado foi semelhante em ambos os grupos (13 (20%) vs. 6 (14%), p = 0,606), e padrão negativo foi mais comum em pacientes COVID-19-negativos (4 (6%) vs. 12 (28%), p = 0,002). Conclusões: Em pacientes com DRET em TRS hospitalizados, um padrão atípico de TC de tórax não pode excluir adequadamente o diagnóstico de COVID-19. Introdução , (DRET) COVID19. COVID19 COVID 19. 19 (TC (TRS Métodos 1 prontosocorro pronto socorro COVID-1 incluídos saúde típica indeterminada atípica negativa Resultados 10 62,3% 623 62 3 (62,3 COVID19positivos COVIDpositivos COVID-19-positivos 2020 125 5 12, 43 mulheres diabetes meses 1284 84 12–84 fosco 40 61% 61 (61% vs 0% (0% COVID19, 19, 0,001. 0001 0,001 . 001 0,001) 6061 60,61 40/66, 4066 40/66 66 (40/66) 100 40/40. 4040 40/40 (40/40) respectivamente COVID19negativos COVIDnegativos 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positivos, positivos, 0,001, 13 (1 20% 20 (20% 14%, 0,606, 0606 0,606 606 0,606) 4 6% (6% 28%, 28 28% (28%) 0,002. 0002 0,002 002 0,002) Conclusões (DRET COVID1 COVID- 62,3 (62, 202 128 8 12–8 (61 (0 000 0,00 00 60,6 406 40/6 (40/66 404 40/4 (40/40 (14 (56 (20 060 0,60 (6 (28% 62, (62 12– 0,0 60, 40/ (40/6 (40/4 (5 (2 06 0,6 (28 0, (40/

ABSTRACT Introduction: Lung diseases are common in patients with end stage kidney disease (ESKD), making differential diagnosis with COVID-19 a challenge. This study describes pulmonary chest tomography (CT) findings in hospitalized ESKD patients on renal replacement therapy (RRT) with clinical suspicion of COVID-19. Methods: ESKD individuals referred to emergency department older than 18 years with clinical suspicion of COVID-19 were recruited. Epidemiological baseline clinical information was extracted from electronic health records. Pulmonary CT was classified as typical, indeterminate, atypical or negative. We then compared the CT findings of positive and negative COVID-19 patients. Results: We recruited 109 patients (62.3% COVID-19-positive) between March and December 2020, mean age 60 ± 12.5 years, 43% female. The most common etiology of ESKD was diabetes. Median time on dialysis was 36 months, interquartile range = 12–84. The most common pulmonary lesion on CT was ground glass opacities. Typical CT pattern was more common in COVID-19 patients (40 (61%) vs 0 (0%) in non-COVID-19 patients, p < 0.001). Sensitivity was 60.61% (40/66) and specificity was 100% (40/40). Positive predictive value and negative predictive value were 100% and 62.3%, respectively. Atypical CT pattern was more frequent in COVID-19-negative patients (9 (14%) vs 24 (56%) in COVID-19-positive, p < 0.001), while the indeterminate pattern was similar in both groups (13 (20%) vs 6 (14%), p = 0.606), and negative pattern was more common in COVID-19-negative patients (4 (6%) vs 12 (28%), p = 0.002). Conclusions: In hospitalized ESKD patients on RRT, atypical chest CT pattern cannot adequately rule out the diagnosis of COVID-19. Introduction ESKD, , (ESKD) COVID19 COVID 19 COVID-1 challenge (CT RRT (RRT COVID19. 19. Methods 1 records typical Results 10 62.3% 623 62 3 (62.3 COVID19positive COVIDpositive COVID-19-positive 2020 125 5 12. 43 female diabetes months 1284 84 12–84 opacities 40 61% 61 (61% 0% (0% nonCOVID19 nonCOVID non non-COVID-1 0.001. 0001 0.001 . 001 0.001) 6061 60.61 40/66 4066 66 (40/66 100 40/40. 4040 40/40 (40/40) respectively COVID19negative COVIDnegative 9 ( 14% 14 (14% 2 56% 56 (56% COVID19positive, positive, 0.001, 13 (1 20% 20 (20% 14%, 0.606, 0606 0.606 606 0.606) 4 6% (6% 28%, 28 28% (28%) 0.002. 0002 0.002 002 0.002) Conclusions (ESKD COVID1 COVID- 62.3 (62. 202 128 8 12–8 (61 (0 nonCOVID1 non-COVID- 000 0.00 00 60.6 40/6 406 (40/6 404 40/4 (40/40 (14 (56 (20 060 0.60 (6 (28% 62. (62 12– non-COVID 0.0 60. 40/ (40/ (40/4 (5 (2 06 0.6 (28 0.

https://doi.org/10.1590/2175-8239-jbn-2023-0029en

Digital tools used on the teaching-learning process in geotechnical engineering teachinglearning teaching learning
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Lemos, Carolina Crissafe dos Santos

; Dias, Luiz Otávio Fontes

; Barbosa, Paulo Sérgio de Almeida

; Marques, Eduardo Antonio Gomes

; Ferraz, Roberto Lopes

; Nalon, Gustavo Henrique

Soils and Rocks

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2024, Volume 47 N. 2 elocation e2024004923

Abstract: En | Text: En | PDF: En

Abstract This article presents the incorporation of information and communication technologies on the teaching-learning process of geotechnical engineering to improve the quality of education and provide practical knowledge to civil engineering students. The content of this paper is divided into three main modules, which are: Treatment of laboratory tests results, Slope stability and Rock mass stability. For this, some software were used, including 2D limit equilibrium stability analysis, stability analysis of rock wedges and a dynamic mathematics, to obtain and analyze soil shear strength parameters, among others. Furthermore, a digital tool was developed to analyze the results gathered in compaction, one-dimensional consolidation, and direct soil shear tests, in order to clarify the relationship between theoretical concepts and practical results of the tests and analyses and to help students on doubts, in addition to increase their interest and motivation to perform the complete interpretation of the collected data. The activities were conducted in classes of geotechnical disciplines of the undergraduate course in Civil Engineering at the Federal University of Viçosa, aiming to promote active learning and improve teaching quality. Based on the results of an applied feedback questionnaire, it was observed that most students were satisfied with the resources used in the classroom, demonstrating that the implemented digital tools work as a didactic instrument that facilitates learning and comprehension of practical problems, in addition to enabling the resolution of several geotechnical engineering problems much more quickly and efficiently. teachinglearning modules are D mathematics parameters others Furthermore compaction onedimensional one dimensional consolidation doubts data Viçosa questionnaire classroom efficiently

https://doi.org/10.28927/sr.2024.004923

Inconstitucionalidade da criminalização do médico pela prática de eutanásia
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Araújo, Paulo Roberto Lemos de

Revista Bioética

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2024, Volume 32 elocation e3640PT

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este estudo objetivou evidenciar a inconstitucionalidade da aplicação dos arts. 121 e 122 do Código Penal brasileiro à prática de eutanásia. Para isso, realizou-se análise crítica desses artigos, considerando os fundamentos constitucionais e casos de paciente com doença grave e incurável acometido por sofrimento insuportável. Serviram de base a Constituição Federal brasileira, a doutrina do direito constitucional e a Ação Direta de Inconstitucionalidade 3.510-DF/2008. Após a análise, verificou-se a incompatibilidade dos referidos artigos com a moldura constitucional, concluindo-se que a aplicação desses dispositivos legais à prática de eutanásia usurpa a autonomia do cidadão para proteger apenas uma dimensão da vida, às custas da violação de direitos fundamentais: dignidade da pessoa humana, liberdade, inviolabilidade da vida privada e não ser submetido a tortura nem a tratamento desumano ou degradante. arts 12 isso realizouse realizou se insuportável brasileira 3.510DF/2008. 3510DF2008 DF 3.510 DF/2008. 3 510 2008 3.510-DF/2008 verificouse verificou concluindose concluindo fundamentais humana liberdade degradante 1 510DF 3.510DF/2008 3510DF200 3510 3.51 DF2008 DF/2008 51 200 3.510-DF/200 3.510DF/200 3510DF20 351 3.5 DF200 DF/200 5 20 3.510-DF/20 3.510DF/20 3510DF2 35 3. DF20 DF/20 2 3.510-DF/2 3.510DF/2 3510DF DF2 DF/2 3.510-DF/ 3.510DF/ DF/ 3.510-DF 3.510DF

Abstract This study aimed to show the unconstitutionality of applying arts. 121 and 122 of the Brazilian Penal Code to the practice of euthanasia. To this end, we carried out a critical analysis of these articles, considering the constitutional foundations and cases of patients with severe and incurable diseases affected by unbearable suffering. It was based on the Brazilian Federal Constitution, the doctrine of constitutional law, and the Direct Action for the Declaration of Unconstitutionality 3,510-DF/2008. After the analysis, we found incompatibility of these articles with the constitutional framework, concluding that the application of these legal provisions to the practice of euthanasia usurps citizen autonomy to protect only one dimension of life, at the expense of violating fundamental rights: dignity of the human person, freedom, inviolability of private life, and not being subjected to torture or inhuman or degrading treatment. arts 12 end suffering Constitution law 3,510DF/2008. 3510DF2008 DF 3,510 DF/2008. 3 510 2008 3,510-DF/2008 framework life rights person freedom treatment 1 510DF 3,510DF/2008 3510DF200 3510 3,51 DF2008 DF/2008 51 200 3,510-DF/200 3,510DF/200 3510DF20 351 3,5 DF200 DF/200 5 20 3,510-DF/20 3,510DF/20 3510DF2 35 3, DF20 DF/20 2 3,510-DF/2 3,510DF/2 3510DF DF2 DF/2 3,510-DF/ 3,510DF/ DF/ 3,510-DF 3,510DF

Resumen Este estudio tuvo como objetivo poner de manifiesto la inconstitucionalidad de la aplicación de los artículos 121 y 122 del Código Penal brasileño a la práctica de eutanasia. Para ello, se llevó a cabo un análisis crítico de estos artículos, teniendo en cuenta los fundamentos constitucionales y casos de paciente con enfermedad grave e incurable que padecen un sufrimiento insoportable. Se utilizaron como base la Constitución Federal brasileña, la doctrina del derecho constitucional y la Acción Directa de Inconstitucionalidad 3.510-DF/2008. Tras el análisis, se comprobó la incompatibilidad de dichos artículos con el marco constitucional y se llegó a la conclusión de que la aplicación de estas disposiciones legales a la práctica de eutanasia usurpa la autonomía del ciudadano para proteger una sola dimensión de la vida, a expensas de la violación de derechos fundamentales: la dignidad de la persona humana, la libertad, la inviolabilidad de la vida privada y el derecho a no ser sometido a tortura ni a trato inhumano o degradante. 12 ello insoportable brasileña 3.510DF/2008. 3510DF2008 DF 3.510 DF/2008. 3 510 2008 3.510-DF/2008 fundamentales humana libertad degradante 1 510DF 3.510DF/2008 3510DF200 3510 3.51 DF2008 DF/2008 51 200 3.510-DF/200 3.510DF/200 3510DF20 351 3.5 DF200 DF/200 5 20 3.510-DF/20 3.510DF/20 3510DF2 35 3. DF20 DF/20 2 3.510-DF/2 3.510DF/2 3510DF DF2 DF/2 3.510-DF/ 3.510DF/ DF/ 3.510-DF 3.510DF

https://doi.org/10.1590/1983-803420243640pt

Elevada expressão de galectina-3 em cicatrizes excessivas: Um estudo piloto galectina3 galectina 3 galectina- excessivas
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FERREIRA, VICTOR FREIRE SALOMÃO

; LEMOS, FELIPE SIMÕES

; RIBEIRO, ROBERTO STEFAN DE ALMEIDA

; DE-ARAÚJO, SILVIO RENAN PINHEIRO VICTOR

; FIGUEREDO, FABIO SANTIAGO

; SILVA, MARIA LIDIA DE ABREU

; DE-OLIVEIRA, FELIPE LEITE

; AMADEU, THAÍS PORTO

Revista Brasileira de Cirurgia Plástica

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2024, Volume 39 N. 3 elocation e0936

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: Cicatrizes hipertróficas e queloides são tipos de cicatrizes excessivas de cicatrização anormal da pele. Galectina-3 (gal-3) é uma proteína da família das lectinas capaz de identificar carboidratos, que podem se combinar e atuar em diversas moléculas. Na literatura, a ação da gal-3 como principal agente regulador da fibrogênese já foi descrita, sendo atualmente utilizada na terapia antifibrótica de diversos órgãos como pulmão e fígado. O objetivo deste estudo piloto foi mostrar resultados preliminares encontrados na expressão de gal-3 em cicatrizes exacerbadas. Método: Foram coletadas 20 amostras de biópsias de cicatrizes excessivas (16 queloides e 4 cicatrizes hipertróficas) e 9 amostras de cicatrizes normais de 22 mulheres e 7 homens. Essas amostras foram processadas para análise histopatológica de rotina por imuno-histoquímica para detectar gal-3. As células positivas para gal-3 foram quantificadas pelo método estereológico utilizando uma grade de 36 pontos. Resultados: A imuno-histoquímica mostrou alta expressão de gal-3 em células endoteliais e epiteliais de todas as amostras de cicatrizes, bem como expressão em células distribuídas pela derme. Maior expressão de gal-3 foi encontrada em amostras de queloides (28% de células positivas) em comparação com cicatrizes normais (18%) e hipertróficas (22%) (p = 0,0075). Os resultados foram obtidos de um pequeno número de pacientes, por se tratar de um estudo piloto. Conclusão: Os dados sugerem que a gal-3 participa do processo de cicatrização e, devido à sua maior presença em amostras de queloides, pode ser um potencial biomarcador para formação de queloides e um alvo terapêutico promissor a ser explorado. Introdução pele Galectina3 Galectina 3 Galectina- gal3 gal (gal-3 carboidratos moléculas literatura gal- descrita fígado exacerbadas Método 2 16 (1 homens imunohistoquímica imuno histoquímica gal3. 3. pontos Resultados derme 28% 28 (28 18% 18 (18% 22% (22% p 0,0075. 00075 0,0075 . 0 0075 0,0075) pacientes Conclusão explorado (gal- 1 ( (2 (18 (22 0007 0,007 007 (gal 000 0,00 00 0,0 0,

ABSTRACT Introduction: Hypertrophic scars and keloids are types of excessive scars from abnormal skin healing. Galectin-3 (gal-3) is a protein from the lectin family capable of identifying carbohydrates, which can combine and act on different molecules. In the literature, the action of gal-3 as the main regulatory agent of fibrogenesis has already been described and is currently used in anti-fibrotic therapy for various organs such as the lung and liver. The objective of this pilot study was to show preliminary results found in the expression of gal-3 in exacerbated scars. Method: Twenty biopsy samples from excessive scars (16 keloids and 4 hypertrophic scars) and 9 samples from normal scars were collected from 22 women and 7 men. These samples were processed for routine histopathological analysis by immunohistochemistry to detect gal-3. Gal-3 positive cells were quantified by the stereological method using a 36-point grid. Results: Immunohistochemistry showed high expression of gal-3 in endothelial and epithelial cells of all scar samples, as well as expression in cells distributed throughout the dermis. Higher gal-3 expression was found in keloid samples (28% positive cells) compared to normal (18%) and hypertrophic (22%) scars (p = 0.0075). The results were obtained from a small number of patients, as this was a pilot study. Conclusion: The data suggest that gal-3 participates in the healing process and, due to its greater presence in keloid samples, it may be a potential biomarker for keloid formation and a promising therapeutic target to be explored. Introduction Galectin3 Galectin 3 Galectin- gal3 gal (gal-3 carbohydrates molecules literature gal- antifibrotic anti fibrotic liver Method 16 (1 2 men gal3. 3. Gal3 Gal Gal- 36point point 36 grid Results dermis 28% 28 (28 18% 18 (18% 22% (22% p 0.0075. 00075 0.0075 . 0 0075 0.0075) patients Conclusion explored (gal- 1 ( (2 (18 (22 0007 0.007 007 (gal 000 0.00 00 0.0 0.

https://doi.org/10.5935/2177-1235.2024rbcp0936-pt

REPERCUSSÕES PSICOSSOCIAIS DO TRANSTORNO MENTAL EM ADOLESCENTES NAS RELAÇÕES FAMILIARES: REVISÃO DE ESCOPO FAMILIARES
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Leite, Roberto Corrêa

; Saidel, Maria Giovana Borges

; Oliveira, Danielle Leite de Lemos

; Jamarim, Michelle Ferraz Martins

; Campos, Claudinei José Gomes

; Lima, Gerusa Marcondes Pimentel de Abreu

Cogitare Enfermagem

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2024, Volume 29 elocation e94004

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO: Objetivo: Mapear a produção científica acerca das repercussões psicossociais do transtorno mental em adolescentes nas relações familiares. Método: Revisão de escopo baseada no referencial do instituto Joanna Briggs, realizada nas bases de dados: Biblioteca Virtual em Saúde (BVS), PubMed, Cumulative Index to Nursing & Allied Health Literature (CINAHL), Scopus, Web of Science e PsycInfo. Os artigos publicados entre janeiro de 2015 a julho de 2023, foram selecionados de forma independente por dois revisores. Resultados: Foram incluídos 19 estudos que revelaram três categorias temáticas, constituídas por repercussões emocionais no bem-estar subjetivo das relações familiares, repercussões emocionais desfavoráveis nas relações familiares e repercussões sociais. Conclusão: Deve-se buscar a melhoria nas interações triádicas entre a família, o adolescente e os profissionais de saúde, a fim de apoiá-los na solução dos dilemas e das repercussões psicossociais desfavoráveis, bem como, primar pela proteção e fortalecimento do bem-estar e da qualidade nas relações. RESUMO Objetivo Método Briggs dados BVS, BVS , (BVS) PubMed CINAHL, CINAHL (CINAHL) Scopus PsycInfo 201 2023 revisores Resultados 1 temáticas bemestar estar sociais Conclusão Devese Deve se família saúde apoiálos apoiá los como (BVS (CINAHL 20 202 2

ABSTRACT Objective: Map the scientific production about the psychosocial repercussions of mental disorder in adolescents in family relationships. Method: Scope review based on the Joanna Briggs Institute framework, conducted in the databases: Virtual Health Library (VHL), PubMed, Cumulative Index to Nursing & Allied Health Literature (CINAHL), Scopus, Web of Science, and PsycInfo. Two reviewers independently selected the articles published between January 2015 and July 2023. Results: Nineteen studies were included, revealing three thematic categories, consisting of emotional repercussions on the subjective well-being of family relationships, unfavorable emotional repercussions in family relationships, and social repercussions. Conclusion: One should seek improvement in the triadic interactions between the family, the adolescent, and health professionals to support them in solving dilemmas and unfavorable psychosocial repercussions, as well as prioritize the protection and strengthening of well-being and quality in relationships. Objective relationships Method framework databases VHL, VHL , (VHL) PubMed CINAHL, CINAHL (CINAHL) Scopus Science PsycInfo 201 2023 Results included categories wellbeing being Conclusion adolescent (VHL (CINAHL 20 202 2

RESUMEN Objetivo: Mapear la producción científica sobre las repercusiones psicosociales del trastorno mental en adolescentes en las relaciones familiares. Método: Revisión de alcance basada en el marco de referencia del instituto Joanna Briggs, realizada en las bases de datos: Biblioteca Virtual en Salud (BVS), PubMed, Cumulative Index to Nursing & Allied Health Literature (CINAHL), Scopus, Web of Science y PsycInfo. Los artículos publicados entre enero de 2015 y julio de 2023, fueron seleccionados de forma independiente por dos revisores. Resultados: Se incluyeron 19 estudios que revelaron tres categorías temáticas, constituidas por repercusiones emocionales en el bienestar subjetivo de las relaciones familiares, repercusiones emocionales desfavorables en las relaciones familiares y repercusiones sociales. Conclusión: Se debe buscar la mejora en las interacciones triádicas entre la familia, el adolescente y los profesionales de salud, a fin de apoyarlos en la solución de los dilemas y de las repercusiones psicosociales desfavorables, así como, velar por la protección y fortalecimiento del bienestar y de la calidad en las relaciones. Objetivo Método Briggs datos BVS, BVS , (BVS) PubMed CINAHL, CINAHL (CINAHL) Scopus PsycInfo 201 2023 revisores Resultados 1 temáticas sociales Conclusión familia salud como (BVS (CINAHL 20 202 2

https://doi.org/10.1590/ce.v29i0.94004

Haff disease: overview and clinical features disease
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Aguiar, Gabriel Rotsen Fortes

; Silva, Roberto Cesar de Moura

; Petruccelli, Karla Cristina Silva

; Oliveira, Michael Nascimento

; Brito, Gabriel Antônio Uchôa de

; Albuquerque, Polianna Lemos Moura Moreira

; Daher, Elizabeth De Francesco

; Silva Junior, Geraldo Bezerra da

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e52

Abstract: En | Text: En | PDF: En

ABSTRACT Haff disease was first described at the beginning of the twentieth century in Europe. Almost a century later, thousands of cases have now been reported in different countries. In Brazil, most cases are observed in the Amazon region, and its associated factors remain to be fully understood. This disease is an uncommon syndrome characterized by intense myalgia and rhabdomyolysis, which manifests within 24 h after consuming some types of freshwater or saltwater fish and crustaceans. A possible heat-stable toxin contained in seafood may be the cause of Haff disease, but this hypothesis is not yet completely proven. This review will describe the clinical and epidemiological aspects of Haff disease with updated literature. Europe later countries Brazil region understood rhabdomyolysis 2 crustaceans heatstable heat stable proven literature

https://doi.org/10.1590/s1678-9946202466052

Induction of puberty vs. induction of ovulation using steroid hormones in beef heifers: a comprehensive review vs heifers
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Sartori, Roberto

; Alves, Rodrigo Lemos Olivieri Rodrigues

; Lopes, Ana Luíza Müller

Animal Reproduction

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2024, Volume 21 N. 3 elocation e20240072

Abstract: En | Text: En | PDF: En

Abstract This review elucidates the physiological and endocrinological processes intrinsic to puberty and ovulation induction protocols in Bos indicus and Bos taurus beef heifers. Puberty is a complex physiological event involving gonadotropic and metabolic changes that lead to sexual maturity, first ovulation, and regular reproductive cycles, enabling females to reproduce. Exposure to progesterone-based hormonal protocols, with or without additional hormones, can reduce the age at first ovulation and improve sexual maturity through stimuli in the hypothalamus-pituitary-gonadal (HPG) axis and uterine development. However, inducing puberty differs from inducing ovulation, as it does not ensure the heifer will continue cycling or be ready to establish and maintain pregnancy after hormonal exposure. Regardless of the pharmacological basis, studies consistently report that beef heifers that had a corpus luteum (CL) prior to the timed-artificial insemination (TAI) protocol, have greater expression of estrus in response to synchronization and greater pregnancy per AI compared to heifers without a CL. The combination of P4 and E2 significantly impacts uterine development, increasing reproductive efficiency. Exposure to P4 causes a positive effect on inducing ovulation. However, studies indicate that the addition of E2 esters at the time of P4 device removal increases the ovulation rate. In general, the studies showed that fertility varied according to the type of the ovulation induction protocol used, but with inconsistent results. Although ovulation induction protocols are strategic tools to accelerate sexual maturity, a holistic view of the entire system is extremely important, combining integration with genetics and nutrition to enhance the reproductive outcomes of beef heifers. Future research is needed to understand and refine these protocols, driving the efficiency of beef cattle production systems. cycles reproduce progesteronebased progesterone based hormones hypothalamuspituitarygonadal hypothalamus pituitary gonadal HPG (HPG development However exposure basis CL (CL timedartificial timed artificial TAI (TAI P E rate general used results important systems

https://doi.org/10.1590/1984-3143-ar2024-0072

Hepatitis A, B and C prevalence among transgender women and travestis in five Brazilian capitals between 2019-2021 A 20192021 2019 2021 2019-202 2019202 201 202 2019-20 201920 20 2019-2 20192 2 2019-
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Moreira, Regina Célia

; Veras, Maria Amélia de Sousa Mascena

; Amianti, Carolina

; McCartney, Daniel Jason

; Silva, Vanessa Cristina Martins

; Lemos, Marcilio Figueiredo

; Compri, Adriana Parise

; Oliveira, Elaine Lopes de

; Bassichetto, Katia Cristina

; Leal, Andréa Fachel

; Knauth, Daniela Ruva

; Magno, Laio

; Dourado, Inês

; Galan, Lenice

; Fonseca, Paula Andrea Morelli

; Queiroz, Rita Suely Bacuri de

; Silva, Roberto José Carvalho da

; Araujo, Sandra

; Miyachi, Marcia Eiko

; Soares, Claudio de Sousa

; Ahagon, Luciana Mitie Kawai

; Mayaud, Philippe

; Sperandei, Sandro

; Motta-Castro, Ana Rita Coimbra

Revista Brasileira de Epidemiologia

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2024, Volume 27 Suppl. 1 elocation e240005.supl.1

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Estimar as prevalências e fatores associados com as hepatites A, B e C em mulheres trans e travestis em cinco regiões do Brasil. Métodos: Estudo transversal com mulheres trans e travestis em cinco capitais brasileiras (Campo Grande, Manaus, Porto Alegre, Salvador e São Paulo), entre dezembro/2019 e julho/2021. As amostras foram submetidas à detecção de marcadores das infecções pelos vírus das hepatites A (HAV), B (HBV) e C (HCV), utilizando-se testes rápidos e quimioluminescência. Amostras positivas foram submetidas à detecção de HBV-DNA e HCV-RNA por PCR em tempo real e genotipadas por sequenciamento de Sanger. Resultados: As análises de 1.317 amostras indicaram taxas de prevalências nas mulheres trans e travestis recrutadas de 69,1%, 24,4% e 1,5% para exposição ao HAV, HBV e HCV, respectivamente. Elevada taxa de suscetibilidade ao HBV (35,7%) e baixa prevalência do marcador vacinal (40,0%) foram observadas. Mostraram-se associadas à presença de anti-HAV: idade maior que 26 anos, autodeclarar-se preta-parda, ter apenas educação básica, história de encarceramento e uso de preservativo na última relação sexual com parceiro casual. Quanto à exposição ao HBV, foi associada a idade maior que 26 anos, cor da pele preto-parda, ter sido profissional do sexo e história de encarceramento. Idade maior de 37 anos, história de abuso sexual e consumo frequente de álcool foram associadas ao HCV. Conclusão: As maiores prevalências de HAV nessa população encontram-se nas regiões Norte e Nordeste. Com relação ao HBV, a prevalência encontrada foi superior à encontrada na população geral, sugerindo maior vulnerabilidade. A prevalência do HCV foi semelhante à encontrada na população geral. Objetivo Brasil Métodos Campo Grande Manaus Alegre Paulo, Paulo , Paulo) dezembro2019 dezembro 2019 dezembro/201 julho2021 julho 2021 julho/2021 (HAV) (HBV (HCV) utilizandose utilizando se quimioluminescência HBVDNA DNA HCVRNA RNA Sanger Resultados 1317 1 317 1.31 691 69 69,1% 244 24 4 24,4 15 5 1,5 respectivamente 35,7% 357 35 7 (35,7% 40,0% 400 40 0 (40,0% observadas Mostraramse Mostraram antiHAV anti anti-HAV 2 anos autodeclararse autodeclarar pretaparda, pretaparda preta parda, parda preta-parda básica casual pretoparda, pretoparda preto preto-parda 3 Conclusão encontramse encontram Nordeste geral vulnerabilidade dezembro201 201 dezembro/20 julho202 202 julho/202 (HAV (HCV 131 31 1.3 6 69,1 24, 1, 35,7 (35,7 40,0 (40,0 dezembro20 20 dezembro/2 julho20 julho/20 13 1. 69, 35, (35, 40, (40, dezembro2 dezembro/ julho2 julho/2 (35 (40 julho/ (3 (4 (

ABSTRACT Objective: To estimate the prevalence and factors associated with hepatitis A, B, and C in transgender women and travestis's networks, in 5 regions of Brazil. Methods: This cross-sectional study includedtransgender women and travestis in five Brazilian capitals (Campo Grande, Manaus, Porto Alegre, Salvador, and São Paulo), between December/2019 and July/2021. All samples were subjected to detection of serological markers of hepatitis virus A (HAV), B (HBV), and C (HCV) infections through rapid tests and chemiluminescent microparticle immunoassays. Positive samples in the screening tests were submitted to detect HBV DNA and HCV-RNA by real-time PCR and genotyped by Sanger sequencing. Results: Analysis of 1,317 samples showed network prevalence rates of 69.1%, 25.1%, and 1.5% for HAV, HBV, and HCV exposure, respectively. A high susceptibility rate to HBV infection (35.7%) and low prevalence of vaccine response markers (40%) were also observed. Age greater than 26 years, self-declared black/brown skin color, having only primary education, history of incarceration, and use of a condom in the last sexual intercourse with a casual partner were associated with total anti-HAV. Exposure to HBV was associated with age greater than 26 years, self-declared black/brown, history of being a sex worker, and incarceration. Age > 37 years, history of sexual abuse, and frequent alcohol consumption were associated with hepatitis C infection. Conclusion: The highest prevalence of HAV in this population was found in the North and Northeast regions, and the prevalence found was higher than that in the general population, suggesting greater vulnerability. The prevalence of HCV infection in our study was similar to that observed in the general population. Objective travestiss s networks Brazil Methods crosssectional cross sectional Campo Grande Manaus Alegre Salvador Paulo, Paulo , Paulo) December2019 December 2019 December/201 July2021 July 2021 July/2021 (HAV) (HBV) (HCV immunoassays HCVRNA RNA realtime real time sequencing Results 1317 1 317 1,31 691 69 69.1% 251 25 25.1% 15 1.5 exposure respectively 35.7% 357 35 7 (35.7% 40% 40 (40% 2 years selfdeclared self declared blackbrown black brown color education incarceration antiHAV. antiHAV anti HAV. anti-HAV worker 3 abuse Conclusion vulnerability December201 201 December/20 July202 202 July/202 (HAV (HBV 131 31 1,3 6 69.1 25.1 1. 35.7 (35.7 4 (40 December20 20 December/2 July20 July/20 13 1, 69. 25. 35. (35. (4 December2 December/ July2 July/2 (35 ( July/ (3

https://doi.org/10.1590/1980-549720240005.supl.1

Roteiros experimentais imagéticos: contribuições semióticas sobre o ensino de reações químicas para alunos surdos imagéticos
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Ferreira, Leonardo Matos

; Rodrigues, Gustavo Fernandes

; Pereira, Lidiane de Lemos Soares

; Benite, Claudio Roberto Machado

Revista Brasileira de Estudos Pedagógicos

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2024, Volume 105 elocation e6008

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O estudo se propõe a analisar, à luz da semiótica peirceana, a compreensão conceitual sobre as reações químicas e as diferentes evidências que comprovam suas ocorrências, com base na realização de experimentos orientados por roteiros imagéticos contendo procedimentos experimentais descritos com recursos visuais. A investigação com elementos da pesquisa participante foi desenvolvida em um centro educacional bilíngue de surdos e contou com a participação de nove alunos da 2ª série do ensino médio, a professora regente, um professor em formação inicial e um em formação continuada. Os dados consistiram na transcrição das interações discursivas coletadas por meio da videogravação e foram submetidos à análise da conversação. Os resultados demonstram que os alunos surdos conseguem executar autonomamente os experimentos por meio do roteiro imagético e evidenciam a manifestação dos conceitos peirceanos de primeiridade, secundidade e terceiridade durante a realização da intervenção pedagógica, o que comprova a potencialidade do uso do roteiro experimental imagético para a elaboração conceitual dos alunos surdos. Resumo analisar peirceana ocorrências visuais ª médio regente continuada conversação primeiridade pedagógica

Abstract: The study proposes to analyze, in light of Peircean semiotics, the conceptual comprehension of chemical reactions and the different evidence that proves their occurrence, by carrying out experiments guided by imagery scripts containing experimental procedures described with visual resources. Our investigation employs elements of participatory research and was developed in a bilingual educational center for the deaf, while the participants were nine second-year high school students, the head teacher, a teacher in initial training and another in continuing training. Data consisted of the transcription of discursive interactions collected from video recordings, which were subjected to conversation analysis. Our results demonstrate that deaf students are able to autonomously execute experiments based on the imagery script, illustrating the manifestation of Peirce's concepts of firstness, secondness and thirdness during pedagogical intervention, ultimately proving the potential of using imagery experimental scripts for the conceptual elaboration of deaf students. Abstract analyze semiotics occurrence resources secondyear second year recordings analysis script Peirces Peirce s firstness intervention

Resumen: El estudio propone analizar, a la luz de la semiótica peirceana, la comprensión conceptual de las reacciones químicas y las diferentes evidencias que prueban sus ocurrencias, a partir de la realización de experimentos orientados por guiones de imágenes que contienen procedimientos experimentales descritos con recursos visuales. La búsqueda con elementos de investigación participativa se desarrolló en un centro educativo bilingüe para sordos y contó con la participación de nueve estudiantes de segundo año de secundaria, la profesora titular, un docente en formación inicial y otro en formación continua. Los datos consistieron en la transcripción de interacciones discursivas recopiladas mediante grabación de vídeo y fueron sometidas a análisis de conversación. Los resultados indican que los estudiantes sordos son capaces de llevar a cabo experimentos basados en el guion de imágenes y demuestran la manifestación de los conceptos peirceanos de primeridad, segundidad y terceridad durante la intervención pedagógica, concluyendo el potencial del uso del guion experimental de imágenes para la elaboración conceptual de los estudiantes sordos. Resumen analizar peirceana ocurrencias visuales secundaria titular continua conversación primeridad pedagógica

https://doi.org/10.24109/2176-6681.rbep.105.6008

10.

Hepatitis A, B and C prevalence among transgender women and travestis in five Brazilian capitals between 2019-2021
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Moreira, Regina Célia

; Veras, Maria Amélia de Sousa Mascena

; Amianti, Carolina

; McCartney, Daniel Jason

; Silva, Vanessa Cristina Martins

; Lemos, Marcilio Figueiredo

; Compri, Adriana Parise

; Oliveira, Elaine Lopes de

; Bassichetto, Katia Cristina

; Leal, Andréa Fachel

; Knauth, Daniela Ruva

; Magno, Laio

; Dourado, Inês

; Galan, Lenice

; Fonseca, Paula Andrea Morelli

; Queiroz, Rita Suely Bacuri de

; Silva, Roberto José Carvalho da

; Araujo, Sandra

; Miyachi, Marcia Eiko

; Soares, Claudio de Sousa

; Ahagon, Luciana Mitie Kawai

; Mayaud, Philippe

; Sperandei, Sandro

; Motta-Castro, Ana Rita Coimbra

Revista Brasileira de Epidemiologia

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2024, Volume 27 Suppl. 1 elocation e240005.supl.1

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/1980-549720240005.supl.1

11.

Is Age Associated with Complications of Atrial Fibrillation Catheter Ablation? Ablation
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Lovatto, Carlos Volponi

; Baldon, Vinicius Louback

; Henriques, Júlia

; Vassallo, Fabrício

; Serpa, Eduardo

; Simões, Aloyr

; Carloni, Hermes

; Cunha, Christiano Lemos

; Gasparini, Dalbian

; Barbosa, Roberto

; Calil, Osmar Araujo

; Serpa, Renato Giestas

; Barbosa, Luiz Fernando Machado

International Journal of Cardiovascular Sciences

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2023, Volume 36 elocation e20210241

Abstract: En | Text: En | PDF: En

Abstract Background Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence increases with age. The management of AF in the elderly is challenging, as it is normally associated with comorbidities and frailty. AF catheter ablation (CA) is a safe and superior alternative to antiarrhythmic drugs (AADs) for the maintenance of sinus rhythm. Objectives To evaluate the rate of complications associated with CA for AF across different age groups. Methods A retrospective analysis of 219 patients who underwent CA for AF between 2016 and 2020 were divided into 3 age groups: less than 60 years, 60 to 70 years, and > 70 years. All the included patients underwent radiofrequency ablation using an electroanatomic mapping system. Categorical variables were evaluated with chi-square and Fisher’s test, and continuous variables were evaluated by Kruskal-Wallis and post-hoc Tamhane’s T2. P values less than 0.05 were considered significant. Results We found an overall total complication rate of 4.6%. The total complication rate was 3.3% in patients < 60 years of age, 5.7% in patients between 60 and 70 years, and 5.2% in patients > 70 years (p = 0.742). No deaths occurred. Conclusion There was no significant difference in the AF CA-related complications when comparing the patients by age group. (AF arrhythmia challenging frailty (CA AADs (AADs rhythm groups 21 201 202 6 7 system chisquare chi square Fishers Fisher s test KruskalWallis Kruskal Wallis posthoc post hoc Tamhanes Tamhane T2 T 005 0 05 0.0 46 4 4.6% 33 3.3 57 5 5.7 52 2 5.2 p 0.742. 0742 0.742 . 742 0.742) occurred CArelated related group 20 00 0. 4.6 3. 5. 074 0.74 74 4. 07 0.7

https://doi.org/10.36660/ijcs.20210241

12.

Delay in the diagnosis and treatment of tuberculosis in prisons in Mato Grosso do Sul, Brazil Sul
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Ribeiro, Carla Celina

; Santos, Andrea da Silva

; Tshua, Daniel Henrique

; Oliveira, Roberto Dias de

; Lemos, Everton Ferreira

; Bourdillon, Paul

; Laranjeira, Alexandre

; Gonçalves, Crhistinne Cavalheiro Maymone

; Andrews, Jason

; Ko, Albert

; Croda, Julio

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0015-2023

Abstract: En | Text: En | PDF: En

ABSTRACT Background: The number of tuberculosis (TB) cases in prisons is higher than that in the general population and has been reported as the most common cause of death in prisons. This study evaluated the delay in the diagnosis and treatment of TB in Brazilian prisons. Methods: A retrospective cohort study was conducted between 2007 and 2015 using data from the five largest male prisons in Mato Grosso do Sul, Brazil. TB case data was collected from the National Database of Notifiable Diseases (SINAN), GAL-LACEN, and prison medical records. The following variables were recorded: prison, year of diagnosis, age, race, education, HIV status, smoking status, comorbidities, number of symptoms, percentage of cures, delay in diagnosis, patient delay, provider delay, laboratory delay, and delay in treatment. Descriptive statistics were used for the variables of interest. Results: A total of 362 pulmonary TB cases were identified. The average time between the first symptom and reporting of data was 94 days. The mean time between symptom onset and laboratory diagnosis was 91 days. The average time from symptom onset to first consultation was 80 days. The time between diagnosis and treatment initiation was 5 days. Conclusions: Delays were significant between reporting of the first symptoms and diagnosis and significantly smaller from the time between notification and start of treatment. Control strategies should be implemented to diagnose cases through active screening, to avoid delays in diagnosis and treatment, and to reduce TB transmission. Background (TB Methods 200 201 Sul Brazil SINAN, SINAN , (SINAN) GALLACEN, GALLACEN GAL LACEN, LACEN GAL-LACEN records recorded age race education status comorbidities cures interest Results 36 identified 9 days 8 Conclusions screening transmission 20 (SINAN 3 2

https://doi.org/10.1590/0037-8682-0015-2023

13.

Comparison of the upper extremity physical performance tests between asymptomatic adults with and without scapular dyskinesis
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Barbosa, Glauber Marques Paraizo

; Matheus, João Paulo Chieregato

; Lemos, Thiago Vilela

; Barbosa, Gladiston Marques Paraizo

; Silva, João Victor Ferreira e

; Souza Júnior, José Roberto de

Fisioterapia em Movimento

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2023, Volume 36 elocation e36121

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução Os testes de desempenho físico (PPTs) são instrumentos de triagem amplamente disponíveis, de fácil aplicação e que podem ser realizados em diferentes ambientes e contextos. A discinesia escapular pode estar relacionada a alterações na angulação glenoumeral, tensão na articulação acromioclavicular, dimensão do espaço subacromial, força/ativação muscular do ombro e posição/movimento umeral. Poucos estudos foram desenvolvidos para entender a influência de aspectos como força, estabilidade, mobilidade e discinese escapular nos escores dos PPTs de membros superiores. Objetivo Comparar o desempenho no Teste de Estabilidade de Extremidade Superior de Cadeia Cinética Fechada (CKCUEST), Teste de Arremesso de Medicine Ball Sentada (SMBT) e Teste de Equilíbrio em Y do Quarto Superior (UQYBT) entre adultos assintomáticos com e sem discinesia escapular. Métodos Estudo transversal com amostra de 20 indivíduos assintomáticos: 10 com discinesia escapular e 10 sem discinesia escapular. Comparou-se o número médio de toques, número de toques normalizados pela altura e pontuação de potência no CKCUEST, distância percorrida pela bola no SMBT, alcance nas direções medial, inferolateral e superolateral, excursão total e escore composto do UQYBT entre ambos os grupos. Resultados Não foram encontradas diferenças significativas para todas as variáveis (p > 0,05). Tamanho de efeito pequeno a moderado foi encontrado para os escores do CKCUEST (d = 0,16-0,78), tamanho de efeito pequeno foi encontrado para a distância no SBMT (d = 0,12) e tamanho de efeito pequeno a moderado foi encontrado para as pontuações do UQYBT (d = 0,02-0,43). O grupo com discinesia escapular apresentou melhor desempenho em todos os testes. Conclusão A pre-sença de discinesia escapular em indivíduos assintomáticos não é um fator relacionado a piores escores em testes de desempenho físico de membros superiores. (PPTs disponíveis contextos glenoumeral acromioclavicular subacromial forçaativação força ativação posiçãomovimento posição movimento umeral estabilidade superiores , (CKCUEST) SMBT (SMBT (UQYBT 2 1 Comparouse Comparou se medial superolateral grupos p 0,05. 005 0,05 . 0 05 0,05) d 0,160,78, 016078 0,16 0,78 16 78 0,16-0,78) 0,12 012 12 0,020,43. 002043 0,02 0,43 02 43 0,02-0,43) presença pre sença (CKCUEST 00 0,0 160 0,160,78 01607 016 0,1 078 0,7 7 0,16-0,78 01 020 0,020,43 00204 002 043 0,4 4 0,02-0,43 0, 0,160,7 0160 07 0,16-0,7 0,020,4 0020 04 0,02-0,4 0,160, 0,16-0, 0,020, 0,02-0, 0,160 0,16-0 0,020 0,02-0 0,16- 0,02-

Abstract Introduction Physical performance tests (PPTs) are screening tools widely available, easy to apply, and that can be performed in different environments and contexts. Scapular dyskinesis can be related to changes in glenohumeral angulation, acromioclavicular joint strain, subacromial space dimension, shoulder muscle strength/activation and humeral position/motion. Few studies were developed to understand the influence of aspects such as strength, stability mobility, and scapular dyskinesis on the scores of the upper extremity PPTs. Objective To compare the performance in the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), Seated Medicine Ball Throw Test (SMBT) and Upper Quarter Y Balance Test (UQYBT) between asymptomatic adults with and without scapular dyskinesis. Methods Cross-sectional study with 20 asymptomatic individuals: 10 with scapular dyskinesis and 10 without scapular dyskinesis. The average number of touches, number of touches normalized by height, and power score in the CKCUEST, distance covered by the ball in the SMBT, reach in the medial, inferolateral, and superolateral directions, total excursion and composite score of the UQYBT were compared between both groups. Results No significant differences were found for all variables (p > 0.05). Small to moderate effect sizes were found for the scores of the CKCUEST (d = 0.16-0.78), a small effect size was found for the distance in the SBMT (d = 0.12), and small to moderate effect sizes were found for the scores of the UQYBT (d = 0.02-0.43). The scapular dyskinesis group presented better performance in all tests. Conclusion The presence of scapular dyskinesis in asymptomatic individuals is not a factor related to worse scores in upper extremity physical performance tests. PPTs (PPTs available apply contexts angulation strain dimension strengthactivation strength activation positionmotion position motion position/motion mobility , (CKCUEST) SMBT (SMBT (UQYBT Crosssectional Cross sectional 2 1 height medial inferolateral directions groups p 0.05. 005 0.05 . 0 05 0.05) d 0.160.78, 016078 0.16 0.78 16 78 0.16-0.78) 0.12, 012 0.12 12 0.12) 0.020.43. 002043 0.02 0.43 02 43 0.02-0.43) (CKCUEST 00 0.0 160 0.160.78 01607 016 0.1 078 0.7 7 0.16-0.78 01 020 0.020.43 00204 002 043 0.4 4 0.02-0.43 0. 0.160.7 0160 07 0.16-0.7 0.020.4 0020 04 0.02-0.4 0.160. 0.16-0. 0.020. 0.02-0. 0.160 0.16-0 0.020 0.02-0 0.16- 0.02-

https://doi.org/10.1590/fm.2023.36121

14.

Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas – 2023 202 20 2
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Marin-Neto, José Antonio

; Rassi Jr, Anis

; Oliveira, Gláucia Maria Moraes

; Correia, Luís Claudio Lemos

; Ramos Júnior, Alberto Novaes

; Luquetti, Alejandro Ostermayer

; Hasslocher-Moreno, Alejandro Marcel

; Sousa, Andréa Silvestre de

; Paola, Angelo Amato Vincenzo de

; Sousa, Antônio Carlos Sobral

; Ribeiro, Antonio Luiz Pinho

; Correia Filho, Dalmo

; Souza, Dilma do Socorro Moraes de

; Cunha-Neto, Edecio

; Ramires, Felix Jose Alvarez

; Bacal, Fernando

; Nunes, Maria do Carmo Pereira

; Martinelli Filho, Martino

; Scanavacca, Maurício Ibrahim

; Saraiva, Roberto Magalhães

; Oliveira Júnior, Wilson Alves de

; Lorga-Filho, Adalberto Menezes

; Guimarães, Adriana de Jesus Benevides de Almeida

; Braga, Adriana Lopes Latado

; Oliveira, Adriana Sarmento de

; Sarabanda, Alvaro Valentim Lima

; Pinto, Ana Yecê das Neves

; Carmo, Andre Assis Lopes do

; Schmidt, Andre

; Costa, Andréa Rodrigues da

; Ianni, Barbara Maria

; Markman Filho, Brivaldo

; Rochitte, Carlos Eduardo

; Macêdo, Carolina Thé

; Mady, Charles

; Chevillard, Christophe

; Virgens, Cláudio Marcelo Bittencourt das

; Castro, Cleudson Nery de

; Britto, Constança Felicia De Paoli de Carvalho

; Pisani, Cristiano

; Rassi, Daniela do Carmo

; Sobral Filho, Dário Celestino

; Almeida, Dirceu Rodrigues de

; Bocchi, Edimar Alcides

; Mesquita, Evandro Tinoco

; Mendes, Fernanda de Souza Nogueira Sardinha

; Gondim, Francisca Tatiana Pereira

; Silva, Gilberto Marcelo Sperandio da

; Peixoto, Giselle de Lima

; Lima, Gustavo Glotz de

; Veloso, Henrique Horta

; Moreira, Henrique Turin

; Lopes, Hugo Bellotti

; Pinto, Ibraim Masciarelli Francisco

; Ferreira, João Marcos Bemfica Barbosa

; Nunes, João Paulo Silva

; Barreto-Filho, José Augusto Soares

; Saraiva, José Francisco Kerr

; Lannes-Vieira, Joseli

; Oliveira, Joselina Luzia Menezes

; Armaganijan, Luciana Vidal

; Martins, Luiz Cláudio

; Sangenis, Luiz Henrique Conde

; Barbosa, Marco Paulo Tomaz

; Almeida-Santos, Marcos Antonio

; Simões, Marcos Vinicius

; Yasuda, Maria Aparecida Shikanai

; Moreira, Maria da Consolação Vieira

; Higuchi, Maria de Lourdes

; Monteiro, Maria Rita de Cassia Costa

; Mediano, Mauro Felippe Felix

; Lima, Mayara Maia

; Oliveira, Maykon Tavares de

; Romano, Minna Moreira Dias

; Araujo, Nadjar Nitz Silva Lociks de

; Medeiros, Paulo de Tarso Jorge

; Alves, Renato Vieira

; Teixeira, Ricardo Alkmim

; Pedrosa, Roberto Coury

; Aras Junior, Roque

; Torres, Rosalia Morais

; Povoa, Rui Manoel dos Santos

; Rassi, Sergio Gabriel

; Alves, Silvia Marinho Martins

; Tavares, Suelene Brito do Nascimento

; Palmeira, Swamy Lima

; Silva Júnior, Telêmaco Luiz da

; Rodrigues, Thiago da Rocha

; Madrini Junior, Vagner

; Brant, Veruska Maia da Costa

; Dutra, Walderez Ornelas

; Dias, João Carlos Pinto

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 6 elocation e20230269

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230269

15.

Neonatal screening for spinal muscular atrophy: A pilot study in Brazil atrophy
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Oliveira Netto, Alice Brinckmann

; Brusius-Facchin, Ana Carolina

; Lemos, Júlia F.

; Pasetto, Fernanda B.

; Brasil, Carolina S.

; Trapp, Franciele B.

; Saute, Jonas Alex Morales

; Donis, Karina Carvalho

; Becker, Michele Michelin

; Wiest, Paloma

; Coutinho, Vivian L. S.

; Castro, Simone Martins de

; Ferreira, Juliana

; Silveira, Cynthia

; Bittar, Maria Fernanda R.

; Wang, Cristina

; Lana, Janaina M.

; França Junior, Marcondes Cavalcante

; Giugliani, Roberto

Genetics and Molecular Biology

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2023, Volume 46 N. 3 elocation e20230126

Abstract: En | Text: En | PDF: En

Abstract Spinal muscular atrophy (SMA) is considered one of the most common autosomal recessive disorders, with an estimated incidence of 1 in 10,000 live births. Testing for SMA has been recommended for inclusion in neonatal screening (NBS) panels since there are several therapies available and there is evidence of greater efficacy when introduced in the pre/early symptomatic phases. In Brazil, the National Neonatal Screening Program tests for six diseases, with a new law issued in 2021 stating that it should incorporate more diseases, including SMA. In the present study, dried blood spot (DBS) samples collected by the Reference Services of Neonatal Screening of RS and SP, to perform the conventional test were also screened for SMA, using real-time PCR, with SALSA MC002 technique. A total of 40,000 samples were analyzed, enabling the identification of four positive cases of SMA, that were confirmed by MLPA. Considering our sampling, Brazil seems to have an incidence comparable to the described in other regions. This work demonstrated that the use of the MC002 technique in samples routinely collected for the conventional NBS program is suitable to screen for SMA in our conditions and can be included in the expansion of the neonatal screening programs. (SMA disorders 10000 10 000 10,00 births (NBS preearly pre early phases diseases 202 study DBS (DBS SP realtime real time PCR MC MC00 40000 40 40,00 analyzed MLPA sampling regions programs 1000 00 10,0 20 MC0 4000 4 40,0 100 0 10, 2 400 40,

https://doi.org/10.1590/1678-4685-gmb-2023-0126

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