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1.
Strain do Átrio Esquerdo pela Técnica de Speckle-Tracking: Contribuição para a Avaliação da Função Diastólica em Pacientes Pediátricos com Doença Renal Crônica SpeckleTracking Speckle Tracking Speckle-Tracking
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Penachio, Flora Maciel
; Diniz, Maria de Fátima Rodrigues
; Laurino, Rosana Sbruzzi Prado
; Watanabe, Andreia
; Sawamura, Karen Saori Shiraishi
; Lianza, Alessandro Cavalcanti
; Menezes, Carolina Rocha Brito
; Silva, Isabela de Sousa Lobo
; Leal, Gabriela Nunes
.
Resumo Fundamento: As complicações cardiovasculares são a principal causa de morte em pacientes pediátricos com doença renal crônica (DRC). A avaliação ecocardiográfica da função diastólica na DRC tem se limitado à avaliação espectral por Doppler espectral e por Doppler tecidual, técnicas sabidamente menos confiáveis na pediatria. O strain do átrio esquerdo (AE) pela técnica do speckle tracking bidimensional (2DST) foi recentemente confirmada como uma medida robusta da função diastólica. Objetivos: Investigar o papel do strain do AE na avaliação da função diastólica de crianças em diferentes estágios da DRC. Métodos: De fevereiro de 2019 a julho de 2022, 55 pacientes com DRC sem sintomas cardiovasculares e 55 controles foram avaliados por ecocardiografia convencional e por ecocardiografia com 2DST. O nível de significância adotado foi de 5% (p < 0,05). Resultados: Pacientes e controles tinham idade similares [9,78 (0,89 – 17,54) vs. 10,72 (1,03 –18,44) anos; p = 0,41] e sexo (36M:19F vs. 34M:21F; p = 0,84) similares. Havia 25 pacientes não dialíticos e 30 pacientes dialíticos. A fração de ejeção do ventrículo esquerdo foi ≥ 55% em todos. Em comparação aos controles, os pacientes com DRC apresentaram strain de reservatório mais baixo (48,22±10,62% vs. 58,52±10,70%) e índice de rigidez do AE mais alto [0,14 (0,08–0,48)%-1 vs. 0,11 (0,06–0,23) %-1]; p<0,0001. A hipertrofia ventricular esquerda associou-se com um strain de reservatório mais baixo (42,05±8,74% vs. 52,99±9,52%), e valores mais altos de índice de rigidez [0,23 (0,11 – 0,48)%-1 vs. 0,13 (0,08–0,23) %-1 e de índice de enchimento do AE (2,39±0,63 cm/s x %-1 vs. 1,74±0,47 cm/s x %-1; p<0,0001). Hipertensão não controlada associou-se com strain de reservatório do AE mais baixo (41,9±10,6% vs. 50,6±9,7; p=0,005). Conclusão: O strain do AE mostrou-se uma ferramenta útil na avaliação de pacientes pediátricos com DRC e associado com fatores de risco cardiovasculares conhecidos. Fundamento . (DRC) tecidual pediatria (AE 2DST DST (2DST Objetivos Métodos 201 2022 5 0,05. 005 0,05 0 05 0,05) Resultados 9,78 978 9 78 [9,7 0,89 089 89 (0,8 17,54 1754 17 54 vs 1072 10 72 10,7 1,03 103 1 03 (1,0 –18,44 1844 18 44 anos 0,41 041 41 36M19F MF 36M 19F M F 34M21F 34M 21F 34M:21F 0,84 084 84 2 3 todos 48,22±10,62% 48221062 48 22 62 (48,22±10,62 58,52±10,70% 58521070 58 52 70 0,14 014 14 [0,1 0,08–0,48%1 0080481 0,08–0,48 % 08 (0,08–0,48)%- 011 11 0,1 0,06–0,23 006023 06 23 (0,06–0,23 %1 %-1] p00001 0001 p<0,0001 associouse associou 42,05±8,74% 4205874 42 8 74 (42,05±8,74 52,99±9,52%, 5299952 52,99±9,52% , 99 52,99±9,52%) 0,23 023 [0,2 (0,1 0,48%1 0481 0,48 0,48)%- 013 13 0,08–0,23 008023 (0,08–0,23 %- 2,39±0,63 239063 39 63 (2,39±0,6 cms cm s 174047 47 1,74±0,4 p<0,0001) 41,9±10,6% 419106 6 (41,9±10,6 50,6±9,7 50697 50 7 p=0,005. p0005 p=0,005 p=0,005) Conclusão mostrouse mostrou conhecidos (DRC 20 202 00 0,0 9,7 97 [9, 0,8 (0, 17,5 175 107 10, 1,0 (1, –18,4 184 4 0,4 04 48,22±10,62 4822106 (48,22±10,6 58,52±10,70 5852107 01 [0, 0,08–0,48% 008048 0,08–0,4 (0,08–0,48)% 0, 0,06–0,2 00602 (0,06–0,2 p0000 000 p<0,000 42,05±8,74 420587 (42,05±8,7 529995 52,99±9,52 0,2 02 0,48% 048 0,48)% 0,08–0,2 00802 (0,08–0,2 2,39±0,6 23906 (2,39±0, 17404 1,74±0, 41,9±10,6 41910 (41,9±10, 50,6±9, 5069 p000 p=0,00 9, [9 (0 17, 1, (1 –18, 48,22±10,6 482210 (48,22±10, 58,52±10,7 585210 [0 00804 0,08–0, (0,08–0,48) 0,06–0, 0060 (0,06–0, p<0,00 42,05±8,7 42058 (42,05±8, 52999 52,99±9,5 0,48) 0080 (0,08–0, 2,39±0, 2390 (2,39±0 1740 1,74±0 41,9±10, 4191 (41,9±10 50,6±9 506 p00 p=0,0 [ ( –18 48,22±10, 48221 (48,22±10 58,52±10, 58521 0,08–0 (0,08–0,48 0,06–0 006 (0,06–0 p<0,0 42,05±8, 4205 (42,05±8 5299 52,99±9, 008 (0,08–0 2,39±0 239 (2,39± 174 1,74± 41,9±10 419 (41,9±1 50,6± p0 p=0, –1 48,22±10 4822 (48,22±1 58,52±10 5852 0,08– (0,08–0,4 0,06– (0,06– p<0, 42,05±8 420 (42,05± 529 52,99±9 (0,08– 2,39± (2,39 1,74 41,9±1 (41,9± 50,6 p=0 48,22±1 482 (48,22± 58,52±1 585 0,08 0,06 (0,06 p<0 42,05± (42,05 52,99± (0,08 2,39 (2,3 1,7 41,9± (41,9 50, p= 48,22± (48,22 58,52± (0,0 p< 42,05 (42,0 52,99 2,3 (2, 41,9 (41, 48,22 (48,2 58,52 42,0 (42, 52,9 2, (2 41, (41 48,2 (48, 58,5 42, (42 52, (4 48, (48 58,
Abstract Background: Cardiovascular complications are the leading cause of mortality in pediatric patients with chronic kidney disease (CKD). Echocardiographic assessment of diastolic function in CKD has been limited to spectral and tissue Doppler imaging, known to be less reliable techniques in pediatrics. Two-dimensional Speckle tracking echocardiography (2DST) derived left atrial (LA) strain has recently been confirmed as a robust measure of diastolic function. Objectives: To investigate LA strain role in diastolic assessment of children at different stages of CKD. Methods: From February 2019 to July 2022, 55 CKD patients without cardiovascular symptoms and 55 controls were evaluated by standard and 2DST echocardiograms. The level of significance was set at 5% (p<0.05). Results: Patients and controls had similar age [9.78 (0.89 – 17.54) vs. 10.72 (1.03 –18,44) years; p = 0.41] and gender (36M:19F vs. 34M:21F; p=0.84). There were 25 non-dialysis patients and 30 dialysis patients. Left ventricular ejection fraction was ≥ 55% in all of them. Comparing CKD and controls, LA reservoir strain was lower (48.22±10.62% vs. 58.52±10.70%) and LA stiffness index was higher [0.14 (0.08–0.48)%-1 vs. 0.11 (0.06–0.23) %-1]; p<0.0001. LV hypertrophy was associated with lower LA reservoir strain (42.05±8.74% vs. 52.99±9.52%), higher LA stiffness [0.23(0.11 – 0.48)%-1 vs. 0.13 (0.08–0.23) %-1 and filling indexes (2.39±0.63 cm/s x %-1 vs. 1.74±0.47 cm/s x %-1; p<0.0001. Uncontrolled hypertension was associated with lower LA reservoir strain (41.9±10.6% vs. 50.6±9.7; p=0.005). Conclusions: LA strain proved to be a feasible tool in the assessment of pediatric CKD patients and was associated with known cardiovascular risk factors. Background . (CKD) imaging pediatrics Twodimensional Two dimensional DST (2DST (LA Objectives Methods 201 2022 5 echocardiograms p<0.05. p005 p<0.05 0 05 (p<0.05) Results 9.78 978 9 78 [9.7 0.89 089 89 (0.8 17.54 1754 17 54 vs 1072 10 72 10.7 1.03 103 1 03 (1.0 –18,44 1844 18 44 years 0.41 041 41 36M19F MF 36M 19F M F 34M21F 34M 21F 34M:21F p=0.84. p084 p=0.84 84 p=0.84) 2 nondialysis non 3 them 48.22±10.62% 48221062 48 22 62 (48.22±10.62 58.52±10.70% 58521070 58 52 70 0.14 014 14 [0.1 0.08–0.48%1 0080481 0.08–0.48 % 08 (0.08–0.48)%- 011 11 0.1 0.06–0.23 006023 06 23 (0.06–0.23 %1 %-1] p00001 0001 p<0.0001 42.05±8.74% 4205874 42 8 74 (42.05±8.74 52.99±9.52%, 5299952 52.99±9.52% , 99 52.99±9.52%) 0.230.11 023011 0.23 [0.23(0.1 0.48%1 0481 0.48 0.48)%- 013 13 0.08–0.23 008023 (0.08–0.23 %- 2.39±0.63 239063 39 63 (2.39±0.6 cms cm s 174047 47 1.74±0.4 41.9±10.6% 419106 6 (41.9±10.6 50.6±9.7 50697 50 7 p=0.005. p0005 p=0.005 005 p=0.005) Conclusions factors (CKD 20 202 p00 p<0.0 (p<0.05 9.7 97 [9. 0.8 (0. 17.5 175 107 10. 1.0 (1. –18,4 184 4 0.4 04 p08 p=0.8 48.22±10.62 4822106 (48.22±10.6 58.52±10.70 5852107 01 [0. 0.08–0.48% 008048 0.08–0.4 (0.08–0.48)% 0. 0.06–0.2 00602 (0.06–0.2 p0000 000 p<0.000 42.05±8.74 420587 (42.05±8.7 529995 52.99±9.52 230 0.230.1 02301 023 0.2 [0.23(0. 0.48% 048 0.48)% 0.08–0.2 00802 (0.08–0.2 2.39±0.6 23906 (2.39±0. 17404 1.74±0. 41.9±10.6 41910 (41.9±10. 50.6±9. 5069 p000 p=0.00 00 p0 p<0. (p<0.0 9. [9 (0 17. 1. (1 –18, p=0. 48.22±10.6 482210 (48.22±10. 58.52±10.7 585210 [0 00804 0.08–0. (0.08–0.48) 0.06–0. 0060 (0.06–0. p<0.00 42.05±8.7 42058 (42.05±8. 52999 52.99±9.5 0.230. 0230 02 [0.23(0 0.48) 0080 (0.08–0. 2.39±0. 2390 (2.39±0 1740 1.74±0 41.9±10. 4191 (41.9±10 50.6±9 506 p=0.0 p<0 (p<0. [ ( –18 p=0 48.22±10. 48221 (48.22±10 58.52±10. 58521 0.08–0 (0.08–0.48 0.06–0 006 (0.06–0 42.05±8. 4205 (42.05±8 5299 52.99±9. 0.230 [0.23( 008 (0.08–0 2.39±0 239 (2.39± 174 1.74± 41.9±10 419 (41.9±1 50.6± p< (p<0 –1 p= 48.22±10 4822 (48.22±1 58.52±10 5852 0.08– (0.08–0.4 0.06– (0.06– 42.05±8 420 (42.05± 529 52.99±9 [0.23 (0.08– 2.39± (2.39 1.74 41.9±1 (41.9± 50.6 (p< 48.22±1 482 (48.22± 58.52±1 585 0.08 0.06 (0.06 42.05± (42.05 52.99± [0.2 (0.08 2.39 (2.3 1.7 41.9± (41.9 50. (p 48.22± (48.22 58.52± 0.0 (0.0 42.05 (42.0 52.99 2.3 (2. 41.9 (41. 48.22 (48.2 58.52 42.0 (42. 52.9 2. (2 41. (41 48.2 (48. 58.5 42. (42 52. (4 48. (48 58.
2.
Combinação de Ferramentas de Telecardiologia para Estratificação de Risco Cardiovascular na Atenção Primária: Dados do Estudo PROVAR+ Primária PROVAR
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Fraga, Lucas Leal
; Nascimento, Bruno Ramos
; Haiashi, Beatriz Costa
; Ferreira, Alexandre Melo
; Silva, Mauro Henrique Agapito
; Ribeiro, Isabely Karoline da Silva
; Silva, Gabriela Aparecida
; Vinhal, Wanessa Campos
; Coimbra, Mariela Mata
; Silva, Cássia Aparecida
; Machado, Cristiana Rosa Lima
; Pires, Magda C.
; Diniz, Marina Gomes
; Santos, Luiza Pereira Afonso
; Amaral, Arthur Maia
; Diamante, Lucas Chaves
; Fava, Henrique Leão
; Sable, Craig
; Nunes, Maria Carmo Pereira
; Ribeiro, Antonio Luiz P.
; Cardoso, Clareci Silva
.
Resumo Fundamento: As ferramentas de telecardiologia são estratégias valiosas para melhorar a estratificação de risco. Objetivo: Objetivamos avaliar a acurácia da tele-eletrocardiografia (ECG) para predizer anormalidades no ecocardiograma de rastreamento na atenção primária. Métodos: Em 17 meses, 6 profissionais de saúde em 16 unidades de atenção primária foram treinados em protocolos simplificados de ecocardiografia portátil. Tele-ECGs foram registrados para diagnóstico final por um cardiologista. Pacientes consentidos com anormalidades maiores no ECG pelo código de Minnesota e uma amostra 1:5 de indivíduos normais foram submetidos a um questionário clínico e ecocardiograma de rastreamento interpretado remotamente. A doença cardíaca grave foi definida como doença valvular moderada/grave, disfunção/hipertrofia ventricular, derrame pericárdico ou anormalidade da motilidade. A associação entre alterações maiores do ECG e anormalidades ecocardiográficas foi avaliada por regressão logística da seguinte forma: 1) modelo não ajustado; 2) modelo 1 ajustado por idade/sexo; 3) modelo 2 mais fatores de risco (hipertensão/diabetes); 4) modelo 3 mais história de doença cardiovascular (Chagas/cardiopatia reumática/cardiopatia isquêmica/AVC/insuficiência cardíaca). Foram considerados significativos valores de p < 0,05. Resultados: No total, 1.411 pacientes realizaram ecocardiograma, sendo 1.149 (81%) com anormalidades maiores no ECG. A idade mediana foi de 67 anos (intervalo interquartil de 60 a 74) e 51,4% eram do sexo masculino. As anormalidades maiores no ECG se associaram a uma chance 2,4 vezes maior de doença cardíaca grave no ecocardiograma de rastreamento na análise bivariada (OR = 2,42 [IC 95% 1,76 a 3,39]) e permaneceram significativas (p < 0,001) após ajustes no modelo 2 (OR = 2,57 [IC 95% 1,84 a 3,65]), modelo 3 (OR = 2,52 [IC 95% 1,80 a 3,58]) e modelo 4 (OR = 2,23 [IC 95% 1,59 a 3,19]). Idade, sexo masculino, insuficiência cardíaca e doença cardíaca isquêmica também foram preditores independentes de doença cardíaca grave no ecocardiograma. Conclusões: As anormalidades do tele-ECG aumentaram a probabilidade de doença cardíaca grave no ecocardiograma de rastreamento, mesmo após ajustes para variáveis demográficas e clínicas. Fundamento Objetivo teleeletrocardiografia tele eletrocardiografia (ECG Métodos meses portátil TeleECGs Tele ECGs cardiologista 15 5 1: remotamente moderadagrave moderada moderada/grave disfunçãohipertrofia disfunção hipertrofia ventricular motilidade forma idade/sexo idadesexo hipertensão/diabetes hipertensãodiabetes hipertensão diabetes (hipertensão/diabetes) Chagas/cardiopatia Chagascardiopatia Chagas cardiopatia reumáticacardiopatia reumática isquêmicaAVCinsuficiência AVC cardíaca. . cardíaca) 005 0 05 0,05 Resultados total 1411 411 1.41 1149 149 1.14 81% 81 (81% intervalo 74 514 51 51,4 masculino 24 2, OR 242 42 IC 95 176 76 1,7 3,39 339 39 3,39] 0,001 0001 001 257 57 2,5 184 84 1,8 3,65, 365 3,65 , 65 3,65]) 252 52 180 80 3,58 358 58 3,58] 223 23 2,2 159 59 1,5 3,19. 319 3,19 19 3,19]) Idade Conclusões teleECG clínicas (hipertensão/diabetes 00 0,0 141 41 1.4 114 14 1.1 8 (81 7 51, 9 1, 3,3 33 0,00 000 25 18 36 3,6 3,65] 3,5 35 22 31 3,1 3,19] 0, 1. 11 (8 3, (
Abstract Background: Tele-cardiology tools are valuable strategies to improve risk stratification. Objective: We aimed to evaluate the accuracy of tele-electrocardiography (ECG) to predict abnormalities in screening echocardiography (echo) in primary care (PC). Methods: In 17 months, 6 health providers at 16 PC units were trained on simplified handheld echo protocols. Tele-ECGs were recorded for final diagnosis by a cardiologist. Consented patients with major ECG abnormalities by the Minnesota code, and a 1:5 sample of normal individuals underwent clinical questionnaire and screening echo interpreted remotely. Major heart disease was defined as moderate/severe valve disease, ventricular dysfunction/hypertrophy, pericardial effusion, or wall-motion abnormalities. Association between major ECG and echo abnormalities was assessed by logistic regression as follows: 1) unadjusted model; 2) model 1 adjusted for age/sex; 3) model 2 plus risk factors (hypertension/diabetes); 4) model 3 plus history of cardiovascular disease (Chagas/rheumatic heart disease/ischemic heart disease/stroke/heart failure). P-values < 0.05 were considered significant. Results: A total 1,411 patients underwent echo; 1,149 (81%) had major ECG abnormalities. Median age was 67 (IQR 60 to 74) years, and 51.4% were male. Major ECG abnormalities were associated with a 2.4-fold chance of major heart disease on echo in bivariate analysis (OR = 2.42 [95% CI 1.76 to 3.39]), and remained significant after adjustments in models (p < 0.001) 2 (OR = 2.57 [95% CI 1.84 to 3.65]), model 3 (OR = 2.52 [95% CI 1.80 to3.58]), and model 4 (OR = 2.23 [95%CI 1.59 to 3.19]). Age, male sex, heart failure, and ischemic heart disease were also independent predictors of major heart disease on echo. Conclusions: Tele-ECG abnormalities increased the likelihood of major heart disease on screening echo, even after adjustments for demographic and clinical variables. Background Telecardiology Tele cardiology stratification Objective teleelectrocardiography tele electrocardiography (ECG (echo PC. . (PC) Methods months protocols TeleECGs ECGs cardiologist code 15 5 1: remotely moderatesevere moderate severe dysfunctionhypertrophy dysfunction hypertrophy dysfunction/hypertrophy effusion wallmotion wall motion follows age/sex agesex sex hypertension/diabetes hypertensiondiabetes hypertension diabetes (hypertension/diabetes) Chagas/rheumatic Chagasrheumatic Chagas rheumatic diseaseischemic diseasestrokeheart stroke failure. failure failure) Pvalues P values 005 0 05 0.0 Results 1411 411 1,41 1149 149 1,14 81% 81 (81% IQR 74 years 514 51 51.4 2.4fold 24fold fold 2.4 OR 242 42 95% 95 [95 176 76 1.7 3.39, 339 3.39 , 39 3.39]) p 0.001 0001 001 257 57 2.5 184 84 1.8 3.65, 365 3.65 65 3.65]) 252 52 180 80 to3.58, to358 to3.58 to3 58 to3.58]) 223 23 2.2 95%CI 95CI 159 59 1.5 3.19. 319 3.19 19 3.19]) Age Conclusions TeleECG variables (PC (hypertension/diabetes 00 0. 141 41 1,4 114 14 1,1 8 (81 7 51. 4fold 24 2. 9 [9 1. 33 3.3 3.39] 0.00 000 25 18 36 3.6 3.65] to35 to3.5 to3.58] 22 31 3.1 3.19] 1, 11 (8 [ 3. to3. (
3.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
4.
Posicionamento do Departamento de Imagem Cardiovascular da Sociedade Brasileira de Cardiologia sobre o Uso do Strain Miocárdico na Rotina do Cardiologista – 2023 202 20 2
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Almeida, André Luiz Cerqueira
; Melo, Marcelo Dantas Tavares de
; Bihan, David Costa de Souza Le
; Vieira, Marcelo Luiz Campos
; Pena, José Luiz Barros
; Del Castillo, José Maria
; Abensur, Henry
; Hortegal, Renato de Aguiar
; Otto, Maria Estefania Bosco
; Piveta, Rafael Bonafim
; Dantas, Maria Rosa
; Assef, Jorge Eduardo
; Beck, Adenalva Lima de Souza
; Santo, Thais Harada Campos Espirito
; Silva, Tonnison de Oliveira
; Salemi, Vera Maria Cury
; Rocon, Camila
; Lima, Márcio Silva Miguel
; Barberato, Silvio Henrique
; Rodrigues, Ana Clara
; Rabschkowisky, Arnaldo
; Frota, Daniela do Carmo Rassi
; Gripp, Eliza de Almeida
; Barretto, Rodrigo Bellio de Mattos
; Silva, Sandra Marques e
; Cauduro, Sanderson Antonio
; Pinheiro, Aurélio Carvalho
; Araujo, Salustiano Pereira de
; Tressino, Cintia Galhardo
; Silva, Carlos Eduardo Suaide
; Monaco, Claudia Gianini
; Paiva, Marcelo Goulart
; Fisher, Cláudio Henrique
; Alves, Marco Stephan Lofrano
; Grau, Cláudia R. Pinheiro de Castro
; Santos, Maria Veronica Camara dos
; Guimarães, Isabel Cristina Britto
; Morhy, Samira Saady
; Leal, Gabriela Nunes
; Soares, Andressa Mussi
; Cruz, Cecilia Beatriz Bittencourt Viana
; Guimarães Filho, Fabio Villaça
; Assunção, Bruna Morhy Borges Leal
; Fernandes, Rafael Modesto
; Saraiva, Roberto Magalhães
; Tsutsui, Jeane Mike
; Soares, Fábio Luis de Jesus
; Falcão, Sandra Nívea dos Reis Saraiva
; Hotta, Viviane Tiemi
; Armstrong, Anderson da Costa
; Hygidio, Daniel de Andrade
; Miglioranza, Marcelo Haertel
; Camarozano, Ana Cristina
; Lopes, Marly Maria Uellendahl
; Cerci, Rodrigo Julio
; Siqueira, Maria Eduarda Menezes de
; Torreão, Jorge Andion
; Rochitte, Carlos Eduardo
; Felix, Alex
.
5.
Cochlear radiation dose and hearing loss in patients with vestibular schwannoma undergoing radiosurgery: systematic review radiosurgery
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Cavalcanti, Gabriela Silva Teixeira
; Lemos, Andrea
; Moretti, Eduarda C.
; Lucena, Camilla Maria G.A.
; Gomes, João Gabriel R.
; Muniz, Lílian F.
; Venâncio, Leonardo G.A.
; Caldas, Silvio
; Leal, Mariana C.
.
Abstract Objectives: To determine the cut-off point of the cochlear radiation dose as a risk factor for hearing loss in patients with vestibular schwannoma treated with radiosurgery. Methods: A systematic review of the literature was performed without language or publication year restrictions in the MEDLINE/PubMed, EMBASE, Web of Science, LILACS/VHL and Cochrane Library databases. Studies that met the following criteria were included: 1) population: adults of both sexes who underwent radiosurgery for vestibular schwannoma treatment; 2) exposure: cochlear radiation; 3) outcome: hearing loss; 4) type of study: cohort. Two independent reviewers conducted the entire review process. The registration number in PROSPERO was CRD42020206128. Results: From the 333 articles identified in the searches, seven were included after applying the eligibility criteria. There was no standardization as to how to measure exposure or outcome in the included studies, and most studies did not present sufficient data to enable meta-analysis. Conclusion: It was not possible to determine a cut-off point for high cochlear dose that could be considered a risk factor for hearing loss. Objectives cutoff cut off Methods MEDLINEPubMed MEDLINE PubMed MEDLINE/PubMed EMBASE Science LILACSVHL LILACS VHL databases 1 population treatment 2 3 4 study cohort process CRD42020206128 CRD Results 33 searches metaanalysis. metaanalysis meta analysis. analysis meta-analysis Conclusion CRD4202020612 CRD420202061 CRD42020206 CRD4202020 CRD420202 CRD42020 CRD4202 CRD420 CRD42 CRD4
6.
Biodiversidad bacteriana en aguas de balnearios mineromedicinales de Ecuador y Venezuela
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Andueza-Leal, Félix Daniel
; Araque-Rangel, Judith
; González-Escudero, Marco
; Sacoto, Diana
; León-Leal, Andrés
; Gutiérrez, María Gabriela
; Flores, Sandra
; Escobar-Arrieta, Sandra
; Medina-Ramírez, Gerardo
.
Abstract The medicinal mineral waters in Ecuador and Venezuela have been used for centuries as medicines by the population of these countries. However, bacterial biodiversity is poorly understood. Therefore, the objective of the work was to know the bacterial biodiversity in the medicinal mineral water’s spas in Ecuador and Venezuela. Water samples were taken at various points in each spa. The microbiological studies were carried out following the schemes proposed by MacFaddin, complemented with the biochemical tests of the API and Microgen gallery. In the waters of the spas of Ecuador, 284 colonies of the genera Acidovorax, Acinetobacter, Actinomyces, Aeromonas, Alcaligenes, Bacillus, Brevibacterium, Brevundimonas, Budvicia, Burkholderia, Citrobacter, Corynebacterium, Edwardsiella, Ewingella, Flavobacterium, Kurthia, Micrococcus, Moraxella were identified. Proteus, Pseudomonas, Psychrobacter, Ralstonia, Staphylococcus, Vibrio, Yersinia, Yokonella and Xenorhabdus. In the waters of the Venezuelan spas, it was possible to identify 158 colonies of the genera Aeromonas, Alcaligenes, Bacillus, Brevundimonas, Burkolderia, Chromobacterium, Citrobacter, Comamonas, Edwardsiella, Enterobacter, Klebsiella, Kluyvera, Moraxella, Plesiomonas, Proteus, Pseudomonas, Ralstonia, Shewanella, Staphylococcus, Weeksella and Vibrio. A clear predominance of Gram-negative bacteria of the Gamma proteobacteria class was observed.
Resumen Las aguas mineromedicinales en Ecuador y Venezuela se utilizan desde hace siglos como medicamentos por la población de estos países. Sin embargo, la biodiversidad bacteriana es poco conocida. Por ello, el objetivo del trabajo fue conocer la biodiversidad bacteriana en el agua de balnearios mineromedicinales de Ecuador y Venezuela. Se tomaron muestras de agua en diversos puntos de cada balneario. Los estudios microbiológicos se realizaron siguiendo los esquemas propuestos por MacFaddin, complementadas con las pruebas bioquímicas de las galerías API y Microgen. En las aguas de los balnearios de Ecuador se identificaron un total de 284 colonias de los géneros Acidovorax, Acinetobacter, Actinomyces, Aeromonas, Alcaligenes, Bacillus, Brevibacterium, Brevundimonas, Budvicia, Burkholderia, Citrobacter, Corynebacterium, Edwardsiella, Ewingella, Flavobacterium, Kurthia, Micrococcus, Moraxella, Proteus, Pseudomonas, Psychrobacter, Ralstonia, Staphylococcus, Vibrio, Yersinia, Yokonella y Xenorhabdus. En las aguas de los balnearios de Venezuela, se logró identificar 158 colonias de los géneros Aeromonas, Alcaligenes, Bacillus, Brevundimonas, Burkolderia, Chromobacterium, Citrobacter, Comamonas, Edwardsiella, Enterobacter, Klebsiella, Kluyvera, Moraxella, Plesiomonas, Proteus, Pseudomonas, Ralstonia, Shewanella, Staphylococcus, Weeksella y Vibrio. Se observó un claro predominio de las bacterias Gram negativas de la clase Gama proteobacterias en los balnearios mineromedicinales de ambos países.
7.
Multisystem Inflammatory Syndrome in Children (MIS-C) temporally related to COVID-19: the experience at a pediatric reference hospital in Colombia
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Lozano-Espinosa, Diego Alejandro
; Camacho-Moreno, Germán
; López-Cubillos, Juan Francisco
; Díaz-Maldonado, Adriana Soraya
; León-Guerra, Oscar Javier
; Galvis-Trujillo, Diego Mauricio
; Sanguino-Lobo, Roy
; Arévalo-Leal, Oscar Guillermo
; del Castillo, Ana María Eraso-Díaz
; Reina-Ávila, María Fernanda
; Cárdenas-Hernández, Vicky Carolina
; Ivankovich-Escoto, Gabriela
; Tremoulet, Adriana H
; Ulloa-Gutiérrez, Rolando
.
Resumo Objetivo: Descrever as características clínicas e os diferentes fenótipos de crianças com síndrome inflamatória multissistêmica na criança temporalmente relacionada com a COVID-19 (do inglês multisystem inflammatory syndrome in children — MIS-C) e avaliar as condições de risco que favorecem a maior gravidade da doença durante um período de 12 meses em um hospital pediátrico de referência na Colômbia. Métodos: Estudo retrospectivo de 12 meses de observação de crianças menores de 18 anos que cumprem os critérios para o MIS-C. Resultados: Vinte e oito crianças foram apresentadas com os critérios do MIS-C. A idade média era de sete anos, e 54% eram do sexo masculino. Para além da febre (100%) (com início quatro dias antes da admissão), as características clínicas mais frequentes eram gastrointestinais (86%) e mucocutâneas (61%). Quatorze crianças (50%) apresentavam sintomas semelhantes aos de Kawasaki. As anomalias ecocardiográficas mais frequentes foram derrame pericárdico (64%), envolvimento valvar (68%), disfunção ventricular (39%) e anomalias coronárias (29%). Tinham linfopenia 75% das crianças. Todas tinham algum teste de coagulação anormal. A maioria recebeu imunoglobulina intravenosa (89%), glucocorticoides (82%), vasopressores (54%) e antibióticos (64%). Tiveram envolvimento mais grave 61% dos pacientes, que precisaram ser internados em unidade de terapia intensiva (mediana de quatro dias, média de seis dias); os preditores de gravidade foram pacientes com fenótipo inflamatório/ MIS-C (odds ratio — OR 26,5; intervalo de confiança — IC95% 1,4–503,7; p=0,029) e erupção cutânea (OR 14,7; IC95% 1,2–178,7; p=0,034). Dois pacientes (7%) apresentavam síndrome de ativação macrofágica. Conclusões: Alteração da artéria coronária, disfunção ventricular e internação na unidade de terapia intensiva foram frequentes, o que nos alerta sobre a importância da suspeita clínica precoce.
Abstract Objective: This study aimed to describe the clinical characteristics and the different phenotypes of children with multisystem inflammatory syndrome in children (MIS-C) temporally related to COVID-19 and to evaluate the risk conditions that favored a greater severity of the disease during a 12-month period at a pediatric reference hospital in Colombia. Methods: A 12-month retrospective observational study of children under the age of 18 years who met criteria for MIS-C. Results: A total of 28 children presented MIS-C criteria. The median age was 7 years. Other than fever (100%) (onset 4 days prior to admission), the most frequent clinical features were gastrointestinal (86%) and mucocutaneous (61%). Notably, 14 (50%) children had Kawasaki-like symptoms. The most frequent echocardiographic abnormalities were pericardial effusion (64%), valvular involvement (68%), ventricular dysfunction (39%), and coronary artery abnormalities (29%). In addition, 75% had lymphopenia. All had at least one abnormal coagulation test. Most received intravenous immunoglobulin (89%), glucocorticoids (82%), vasopressors (54%), and antibiotics (64%). Notably, 61% had a more severe form of the disease and were admitted to an intensive care unit (median 4 days, mean 6 days); the severity predictors were patients with the inflammatory/MIS-C phenotype (OR 26.5; 95%CI 1.40–503.7; p=0.029) and rash (OR 14.7; 95%CI 1.2–178.7; p=0.034). Two patients had macrophage activation syndrome. Conclusions: Coronary artery abnormalities, ventricular dysfunction, and intensive care unit admission were frequent, which needs to highlight the importance of early clinical suspicion.
8.
Post-natal prognostic factors in CDH: experience of 11 years in a referral center in Brazil Postnatal Post natal CDH 1
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Nam, Camila Pinho Brasileiro Martins
; Campos, Carolina Vieira
; Leal, Gabriela Nunes
; Tannuri, Uenis
; Ceccon, Maria Esther Jurfest Rivero
; Carvalho, Werther Brunow de
.
Abstract Objective To describe post-natal risk factors associated with death in Newborns (NB) with Congenital Diaphragmatic Hernia (CDH) in a Brazilian reference center. Methods In this retrospective cohort study, post-natal clinical factors of all NB diagnosed with CDH were reviewed in an 11-year period (2007‒2018). The primary outcome was death. Secondary outcomes included clinical features, prognostic indexes, type of mechanical ventilation, complications during hospitalization and surgical repair. Results After applying the exclusion criteria, the authors analyzed 137 charts. Overall mortality was 59% (81/137), and the highest rates were observed for low-birth-weight NB (87%), syndromic phenotype (92%), and those with major malformations (100%). Prognostic indexes such as Apgar, SNAPPE-II and 24hOI (best oxygenation index in 24 hours) were all associated with poor evolution. In a multivariate analysis, only birth weight and 24hOI were statistically significant risk factors for mortality, with a reduction in mortality risk of 17.1% (OR = 0.829, 95% IC 0.72‒0.955, p = 0.009) for each additional 100g at birth and an increase by 26.5% (OR = 1.265, 95% IC 1.113‒1.436, p = 0.0003) for each unitary increase at the 24hOI. Conclusion Prognostic indexes are an important tool for predicting outcomes and improving resource allocation. Post-natal risk factors may be more suitable for settings where antenatal diagnosis is not universal. Classical risk factors, such as prematurity, low birth weight, higher need for supportive care, and poorer prognostic indexes were associated with mortality in our CDH population. postnatal post natal (NB (CDH center study 11year year 11 2007‒2018. 20072018 2007‒2018 . 2007 2018 (2007‒2018) features ventilation repair criteria 13 charts 59 81/137, 81137 81/137 , 81 (81/137) lowbirthweight 87%, 87 87% (87%) 92%, 92 92% (92%) 100%. 100 100% (100%) Apgar SNAPPEII SNAPPE II hOI best 2 hours evolution analysis 171 17 1 17.1 OR 0829 0 829 0.829 95 0720955 72 955 0.72‒0.955 0.009 0009 009 g 265 26 5 26.5 1265 1.265 11131436 113 436 1.113‒1.436 0.0003 00003 0003 allocation Postnatal Post universal prematurity care population 2007201 2007‒201 200 201 (2007‒2018 8113 81/13 8 (81/137 (87% 9 (92% 10 (100% 17. 082 82 0.82 072095 7 0.72‒0.95 0.00 000 00 26. 126 1.26 1113143 43 1.113‒1.43 0.000 0000 200720 2007‒20 20 (2007‒201 811 81/1 (81/13 (87 (92 (100 08 0.8 07209 0.72‒0.9 0.0 12 1.2 111314 4 1.113‒1.4 20072 2007‒2 (2007‒20 81/ (81/1 (8 (9 (10 0. 0720 0.72‒0. 1. 11131 1.113‒1. 2007‒ (2007‒2 (81/ ( (1 072 0.72‒0 1113 1.113‒1 (2007‒ (81 07 0.72‒ 111 1.113‒ (2007 0.72 1.113 (200 0.7 1.11 (20 1.1 (2
9.
The risks of the new morbidities acquired during pediatric onco-critical care and their life-shortening effects oncocritical onco critical lifeshortening life shortening
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Santos, Gabriela Maria Virgílio Dias
; Araujo, Orlei Ribeiro de
; Leal, Priscila de Biasi
; Arduini, Rodrigo Genaro
; Sousa, Rosa Massa Kikuchi de
; Caran, Eliana Maria Monteiro
; Silva, Dafne Cardoso Bourguignon da
.
Abstract Objective: The authors investigated the functional status at ICU admission and at hospital discharge, and the impact of dysfunctions on survivors’ lifespan. Method: Single-center retrospective cohort. The FSS (Functional Status Scale) was calculated at ICU admission and at hospital discharge. A new morbidity was defined as an increase in FSS ≥ 3. Results: Among 1002 patients, there were 855 survivors. Of these, 194 (22.6%) had died by the end of the study; 45 (5.3%) had a new morbidity. Means in the motor domain at admission and discharge were 1.37 (SD: 0.82) and 1.53 (SD 0.95, p = 0.002). In the feeding domain, the means were 1.19 (SD 0.63) and 1.30 (SD 0.76), p = 0.002; global means were 6.93 (SD 2.45) and 7.2 (SD 2.94), p = 0.007. Acute respiratory failure requiring mechanical ventilation, the score PRISM IV, age < 5 years, and central nervous system tumors were independent predictors of new morbidity. New morbidity correlated with lower odds of survival after hospital discharge, considering all causes of death (p = 0.014), and was independently predictive of death (Cox hazard ratio = 1.98). In Weibull models, shortening in the life span of 14.2% (p = 0.014) was estimated as a new morbidity. Conclusions: New morbidities are related to age, disease severity at admission, and SNC tumors. New morbidities, in turn, correlate with lower probabilities of survival and shortening of the remaining life span. Physical rehabilitation interventions in this population of children may have the potential to provide an increase in lifespan. Objective survivors lifespan Method Singlecenter Single center cohort Functional Scale 3 Results 100 patients 85 these 19 22.6% 226 22 6 (22.6% study 4 5.3% 53 (5.3% 137 1 37 1.3 SD 0.82 082 0 82 153 1.5 095 95 0.95 0.002. 0002 0.002 . 002 0.002) 119 1.1 0.63 063 63 130 30 0.76, 076 0.76 , 76 0.76) 693 93 6.9 2.45 245 2 72 7 7. 2.94, 294 2.94 94 2.94) 0007 007 0.007 ventilation IV years 0.014, 0014 0.014 014 Cox 1.98. 198 1.98 98 1.98) models 142 14 14.2 Conclusions turn 10 8 22.6 (22.6 5.3 (5.3 13 1. 0.8 08 15 09 9 0.9 000 0.00 00 11 0.6 06 07 0.7 69 6. 2.4 24 29 2.9 001 0.01 01 1.9 14. 22. (22. 5. (5. 0. 0.0 2. (22 (5 (2 (
10.
In vitro embryo production in small ruminants: what is still missing? ruminants missing
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Souza-Fabjan, Joanna Maria Gonçalves
; Leal, Gabriela Ramos
; Monteiro, Clara Ana Santos
; Batista, Ribrio Ivan Tavares Pereira
; Barbosa, Nathalia Oliveira
; Freitas, Vicente José Figueirêdo
.
Abstract In vitro embryo production (IVEP) is an extremely important tool for genetic improvement in livestock and it is the biotechnology that has grown the most recently. However, multiple ovulation followed by embryo transfer is still considered the leading biotechnology for embryo production in small ruminants. This review aimed to identify what is still missing for more efficient diffusion of IVEP in small ruminants, going through the IVEP steps and highlighting the main factors affecting the outcomes. Oocyte quality is essential for the success of IVEP and an aspect to be considered in small ruminants is their reproductive seasonality and strategies to mitigate the effect of season. The logistics for oocyte collection from live females is more complex than in cattle, and tools to simplify this collection system and/or to promote an alternative way of recovering oocytes may be an important point in this scenario. The heterogeneity of oocytes collected from growing follicles in live females or from ovaries collected from abattoirs remains a challenge, and there is a demand to standardize/homogenize the hormonal stimulatory protocols and IVM protocols for each source of oocytes. The use of sexed semen is technically possible, however the low market demand associated with the high costs of the sexing process prevents the routine use of this technique, but its higher availability is an important aspect aiming for greater dissemination of IVEP. New noninvasive approaches for embryo selection are key factors since the selection for transfer or cryopreservation is another difficulty faced among laboratories. Embryo selection is based on morphological traits, although these are not necessarily reliable in predicting pregnancy. Several issues described in this review must be considered by researchers in other to promote the diffusion of IVEP in small ruminants. (IVEP recently However outcomes season cattle andor scenario challenge standardizehomogenize standardize homogenize possible technique laboratories traits pregnancy
11.
Documentação automatizada de parâmetros vitais em enfermarias utilizando estações portáteis - Efeito no acionamento adequado do time de resposta rápida: um protocolo de um ensaio clínico randomizado em clusters
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Ribeiro, José Cesar
; Sgorbissa, Cristina
; Silva, Karla Aparecida
; Braz, Maria de Lourdes Dias
; Horak, Ana Clara Peneluppi
; Nicola, Marina Lazzari
; Gurgel, Rodrigo Magalhães
; Tokunaga, Samira Martins
; Negrelli, Karina Leal
; Murizine, Gabriela Souza
; Medrado Júnior, Fernando
; Coli, Rita de Cassia Pires
; Cavalcanti, Alexandre Biasi
; Marcadenti, Aline
.
RESUMO Objetivo: Avaliar a eficácia da solução Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ em acionar o time de resposta rápida em tempo hábil, em comparação com o acionamento manual. Métodos: O estudo Hillrom é um ensaio clínico unicêntrico, aberto, de superioridade, randomizado em clusters em paralelo (taxa de alocação 1:1) realizado em um hospital terciário. Serão incluídos dois grupos de três enfermarias com 28 leitos (um grupo intervenção e um grupo controle). As enfermarias serão distribuídas aleatoriamente para utilizar a solução automatizada Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ (grupo intervenção) ou para manter a rotina habitual (grupo controle) em relação ao acionamento do time de resposta rápida. O desfecho primário será o número absoluto de ocorrências de acionamento do time de resposta rápida em tempo hábil. Como desfechos secundários, características clínicas como mortalidade, parada cardíaca, necessidade de internação em unidade de terapia intensiva e duração da hospitalização serão avaliadas de forma exploratória de acordo com os grupos. Estimou-se uma amostra de 216 acionamentos de time de resposta rápida, para identificar uma possível diferença entre os grupos. O protocolo foi aprovado pelo Comitê de Ética em Pesquisa institucional. Resultados esperados: Espera-se que a solução automatizada Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ seja mais eficaz no acionamento do sistema de chamada de enfermeiros, para acionar o time de resposta rápida em tempo hábil e de maneira adequada, em comparação com o acionamento manual (prática habitual). ClinicalTrials.gov: NCT04648579
ABSTRACT Objective: To evaluate the effectiveness of the Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ solution in activating the rapid response team in a timely manner compared to manual activation. Methods: The Hillrom study is a single-center, open-label, superiority, cluster-randomized, parallel-group (1:1 allocation ratio) clinical trial that will be conducted in a tertiary hospital. Two sets of three wards with 28 beds will be included (one as the intervention cluster and the other as the control). The wards will be randomly assigned to use the Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ automated solution (intervention cluster) or to maintain the usual routine (control cluster) regarding rapid response team activation. The primary outcome will be the absolute number of episodes of rapid response team triggering in an appropriate time; as secondary outcomes, clinical features (mortality, cardiac arrest, need for intensive care unit admission and duration of hospitalization) will be assessed according to clusters in an exploratory way. A sample size of 216 rapid response team activations was estimated to identify a possible difference between the groups. The protocol has been approved by the institutional Research Ethics Committee. Expected results: The Welch Allyn Connex® Spot Monitor/Hillrom Connecta™ automated solution is expected to be more effective in triggering the nurse call system to activate the rapid response team in a timely and adequate manner compared to manual triggering (usual practice). ClinicalTrials.gov: NCT04648579
12.
Consensus for the use of flash glucose monitoring in the Colombian adult population with type 1 and 2 diabetes mellitus
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GÓMEZ-MEDINA, ANA MARÍA
; YEPES-CORTÉS, CARLOS AUGUSTO
; DUARTE-OSORIO, ANDRÉS
; HENAO-CARRILLO, DIANA
; JARAMILLO-PARRA, PABLO
; STEPHENS-LEAL, INGRID
; GARCÍA-MORALES, OLGA MILENA PAOLA
; RUBIO-REYES, CLAUDIA
; SALEJ-DURÁN, VANESSA
; MONROY-RIVERA, GABRIELA
; ZULUAGA-MONTOYA, ISABELLA
; BOTERO-ARANGO, JOSÉ FERNANDO
; BONELO, KAREN FERIZ
.
Resumen Introducción: en Colombia las Guías de Práctica Clínica para el manejo del paciente con diabetes tipo 1 (DM1) y tipo 2 (DM2) no mencionan el uso del monitoreo de glucosa flash dado que dicho sistema no estaba disponible. El objetivo del presente trabajo fue establecer un grupo de recomendaciones sobre el uso del monitoreo intermitente flash en Colombia. Métodos: el grupo de expertos estuvo conformado por ocho médicos colombianos expertos en el manejo de pacientes con DM1 y DM2 de diversas ciudades de Colombia, una enfermera licenciada educadora en diabetes, una paciente con diagnóstico de DM1 y un experto metodológico. A través de Zoom Enterprise versión de la aplicación de videoconferencia Zoom (Zoom Video Communications, San Jose, California) el grupo generó las preguntas con metodología Metaplan. Posteriormente, se realizó una búsqueda sistemática de la literatura y análisis de la evidencia. Las recomendaciones se generaron mediante grupo nominal según el grado de evidencia y la formaleza de la recomendación siguiendo la metodología GRADE. Resultados: se generaron recomendaciones clínicas enfocadas a: a) paciente con diagnóstico de DM1 e hipoglucemia; b) paciente con diagnóstico de DM1 y mal control metabólico, c) paciente con diagnóstico de DM tipo 2 tratado con insulina, d) diabetes pregestacional, e) calidad de vida y f) uso intrahospitalario. Conclusiones: las recomendaciones clínicas del presente consenso orientan la toma de decisiones clínicas con respecto al uso de monitoreo intermitente flash en el paciente con diagnóstico de diabetes en diferentes escenarios clínicos. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2239).
Abstract Introduction: in Colombia, the Clinical Practice Guidelines for the treatment of patients with type 1 (DM1) and type 2 (DM2) diabetes do not mention the use of flash glucose monitoring, as this system was not available. The objective of this study was to establish a set of recommendations for the use of intermittent flash monitoring in Colombia. Methods: the group of experts consisted of eight Colombian physicians from different cities within Colombia, with expertise in the management of patients with DM1 and DM2; a certified diabetes nurse educator; a patient with DM1; and a methodological expert. Using the Zoom Enterprise video conferencing application (Zoom Video Communications, San Jose, California), the group generated questions through the Metaplan method, then carried out a systematic literature search and evidence review. The recommendations were made according to the degree of evidence and strength of the recommendation, following the GRADE method. Results: clinical recommendations were made for: a) patients with DM1 and hypoglycemia; b) patients with DM1 and poor metabolic control; c) patients with insulin-treated DM2; d) pregestational diabetes; e) quality of life; and f) inpatient use. Conclusions: this consensus's clinical recommendations guide clinical decision making with regard to the use of intermittent flash monitoring in patients with diabetes in various clinical settings. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2239).
13.
Impact of ERT and follow-up of 17 patients from the same family with a mild form of MPS II
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Stephan, Bruno de Oliveira
; Quaio, Caio Robledo
; Spolador, Gustavo Marquezani
; Paula, Ana Carolina de
; Curiati, Marco Antonio
; Martins, Ana Maria
; Leal, Gabriela Nunes
; Tenorio, Artur
; Finzi, Simone
; Chimelo, Flavia Teixeira
; Matas, Carla Gentile
; Honjo, Rachel Sayuri
; Bertola, Debora Romeo
; Kim, Chong Ae
.
Abstract Background: Mucopolysaccharidosis type II, also known as Hunter syndrome, is a rare X-linked recessive disorder caused by deficiency of the lysosomal enzyme Iduronate-2- Sulfatase (IDS), leading to progressive accumulation of Glycosaminoglycans (GAGs) in several organs. Over the years, Enzyme Replacement Therapy (ERT) has provided significant benefits for patients, retarding the natural progression of the disease. Results: The authors evaluated 17 patients from the same family with a mild form of MPS type II; the proband had developed acute decompensated heart failure refractory to clinical measurements at 23 years and needed a rather urgent heart transplant; however, he died from surgical complications shortly after the procedure. Nevertheless, subsequent to his tragic death, 16 affected male relatives were detected after biochemical tests identifying the low or absent activity of the IDS enzyme and confirmed by molecular analysis of the IDS gene. Following diagnosis, different options of treatment were chosen: 6 patients started ERT with Elaprase® (Idursulfase) soon after, while the other 10 remained without ERT. Eventually, 4 patients in the latter group began ERT with Hunterase® (Idursulfase Beta). None presented adverse effects to either form of the enzyme. Among the 6 individuals without any ERT, two died of natural causes, after reaching 70 years. Despite the variable phenotype within the same family (mainly heart dysfunctions and carpal tunnel syndrome), all 14 remaining patients were alive with an independent lifestyle. Conclusion: Here, the authors report the variable progress of the disease with and without ERT in a large Brazilian family with a slowly progressive form of MPS II, harboring the same missense variant in the IDS gene.
14.
Coxsackievirus A6 strains causing an outbreak of hand-foot-and-mouth disease in Northeastern Brazil in 2018
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Luchs, Adriana
; Azevedo, Lais Sampaio de
; Souza, Ellen Viana de
; Medeiros, Roberta Salzone
; Souza, Yasmin França Viana Pires de
; Teixeira, Dalane Loudal Florentino
; Carneiro, Thiago Franco de Oliveira
; Alencar, Gabriela Maria Fernandes de
; Morais, Fernanda Lúcia de Sousa Leite
; Pinto, Diana de Fátima Alves
; Okay, Thelma Suely
; Yamamoto, Lidia
; Morais, Vanessa dos Santos
; Araújo, Emerson Luiz Lima
; Leal, Elcio
; Costa, Antonio Charlys da
.
Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT Hand-foot-and-mouth disease (HFMD) is a highly contagious viral disease commonly associated to Enteroviruses (EV). During 2018, Brazil faced massive HFMD outbreaks spread across the country. This study aimed to characterize the EV responsible for the HFMD outbreak that occurred in Paraiba State, Brazilian Northeastern region, in 2018, followed by a phylogenetic analysis to detail information on its genetic diversity. A total of 49 serum samples (one from each patient) collected from children ≤ 15 years old, clinically diagnosed with HFMD were tested for EV using conventional RT-PCR and RT-qPCR. EV infection was confirmed in 71.4% (35/49) of samples. The mean and median ages were 1.83 years and one year old, respectively. Twenty-two EV-positive samples were successfully sequenced and classified as EV-A species; 13 samples were also identified with the CV-A6 genotype. The phylogenetic analysis (VP1 region) of three samples revealed that the detected CV-A6 strains belonged to sub-lineage D3. The CV-A6 strains detected here clustered with strains from South America, Europe and West Asia strains that were also involved in HFMD cases during the 2017-2018 seasons, in addition to the previously detected Brazilian CV-A6 strains from 2012 to 2017, suggesting a global co-circulation of a set of different CV-A6 strains introduced in the country at different times. The growing circulation of the emerging CV-A6 associated with HFMD, together with the detection of more severe cases worldwide, suggests the need for a more intense surveillance system of HFMD in Brazil. In addition, this investigation was performed exclusively on serum samples, and the analysis of whole blood samples should be considered and could have shown advantages when employed in the diagnosis of enteroviral HFMD outbreaks.
15.
SARS-CoV-2 and rhinovirus infections: are there differences in clinical presentation, laboratory abnormalities, and outcomes in the pediatric population?
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Pereira, Maria Fernanda Bádue
; Suguita, Priscila
; Litvinov, Nadia
; Farhat, Sylvia Costa Lima
; Paula, Camila Sanson Yoshino de
; Lázari, Carolina dos Santos
; Bedê, Pedro Vale
; Framil, Juliana Valeria de Souza
; Bueno, Catarina
; Branas, Priscila Cristina Abduch Adas
; Guimarães, Irina Monteiro da Costa
; Leite, Marcia Marques
; Navega, Ana Carolina Barsaglini
; Nanbu, Danilo Yamamoto
; Schvartsman, Claudio
; Pinho, João Renato Rebello
; Silva, Clovis Artur Almeida
; Marques, Heloisa Helena de Sousa
; Eisencraft, Adriana Pasmanik
; Rossi Jr, Alfio
; Delgado, Artur Figueiredo
; Leal, Gabriela Nunes
; Gibelli, Maria Augusta Cicaroni
; Palmeira, Patricia
; Sakita, Neusa Keico
; Santos, Emilly Henrique dos
; Rocha, Mussya Cisotto
; Kanunfre, Kelly Aparecida
; Okay, Thelma Suely
; Carneiro-Sampaio, Magda
; Carvalho, Werther Brunow de
.
Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT This study aims to assess COVID-19 and other respiratory viruses in pediatric patients. Between April 17 and September 30, 2020, we collected 1,566 respiratory samples from 1,044 symptomatic patients who were younger than 18 years old to assess SARS-CoV-2 infection. Of these, 919 were analyzed for other respiratory pathogens (ORP). Patients with laboratory-confirmed COVID-19 or ORP were included. We evaluated 76 pediatric COVID-19 infections and 157 other respiratory virus infections. Rhinovirus occurred in 132/157 (84%). COVID-19 patients who were significantly older, had more fevers, headaches and pneumonia than those with ORP. The median white blood cell count was lower in patients with SARS-CoV-2 than in those with ORP (6,470 versus 8,170; p=0.02). COVID-19 patients had significantly worse symptoms than those with ORP.
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You can enrich your search in a very simple way. Use the search indexes combined with the connectors (AND or OR) and specify more your search.
For example, if you want to search for articles about
cases of dengue in Brasil in 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
See below the complete list of search indexes that can be used:
Index code | Element |
---|---|
ti | article title |
au | author |
kw | article keywords |
subject | subject (title words, abstract and keywords) |
ab | abstract |
ta | journal short title (e.g. Cad. Saúde Pública) |
journal_title | journal full title (e.g. Cadernos de Saúde Pública) |
la | publication language code (e.g. pt - Portuguese, es - Spanish) |
type | document type |
pid | publication identifier |
publication_year | publication year of publication |
sponsor | sponsor |
aff_country | country code of the author's affiliation |
aff_institution | author affiliation institution |
volume | article volume |
issue | article issue |
elocation | elocation |
doi | DOI number |
issn | journal ISSN |
in | SciELO colection code (e.g. scl - Brasil, col - Colômbia) |
use_license | article usage license code |