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ABSTRACT BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. OBJECTIVES: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. DESIGN AND SETTING: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. METHODS: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student’s t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. RESULTS: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. CONCLUSIONS: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases. BACKGROUND Brazil OBJECTIVES Thus Fulniô Fulni ô SETTING crosssectional cross sectional Populations METHODS biopsy ShapiroWilk, ShapiroWilk Shapiro Wilk, Wilk Shapiro-Wilk MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney Students Student s ttests t tests used described 5 5% RESULTS 10 940 94 0 94.0% 844 84 4 84.4% Fiftyone Fifty one CONCLUSIONS cases 1 9 94.0 8 84.4 94. 84.

https://doi.org/10.1590/1516-3180.2022.0355.r1.10042023

TECHNOLOGY FOR SAFE CARE IN CATASTROPHIC SITUATIONS: PROTOTYPE MEDIATED BY SOFT DESIGN SCIENCE RESEARCH SITUATIONS
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Costa, Cássia Janne Nonato da

; Mendes, Vanessa Alves

; Oliveira, Patrícia Rosa de

; Santos, Emílio Carlos Alves dos

; Guimarães, Michelly Kim de Oliveira Rosa

; Martins, Edna Thais Jeremias

; Ribeiro, Mara Regina Rosa

; Ferreira, Gímerson Erick

Texto & Contexto - Enfermagem

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2024, Volume 33 elocation e20230335

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Objetivo: producir tecnología que promueva la seguridad del cuidado en la atención hospitalaria en situaciones catastróficas. Método: investigación aplicada realizada en un hospital público ubicado en la región Centro-Oeste de Brasil, entre los meses de septiembre de 2020 y agosto de 2021, mediante la aplicación de la Soft Design Science Research, en siete etapas: perfilamiento del problema, con análisis descriptivo de indicadores hospitalarios; explicación del problema como un conjunto específico de requisitos, mediante la aplicación de escalas con 108 profesionales de la salud y 75 profesionales de enfermería, y análisis descriptivo e inferencial; generalización del problema, mediante revisión de alcance para sistematizar una clase de problemas; estructuración de los componentes de la solución a través de un taller guiado por el design thinking; comparación entre el problema específico y los requisitos generales para alinear la solución; definición de la solución; construcción de la solución. Resultados: la inmersión en el problema reveló resultados que anuncian el empeoramiento de las condiciones de salud de los pacientes y la percepción negativa de trabajadores y gestores sobre el clima de seguridad en situaciones catastróficas, acentuada por la insatisfacción del equipo de enfermería con el soporte ofrecido por la organización. La proyección de este escenario fue fundamental para sistematizar las soluciones que potencien la seguridad, ya producidas para este fin, y para realizar experimentos orientados al diseño, alineación, estructuración, prototipado e iteración del prototipo construido. Conclusión: se formó un Equipo de Respuesta Rápida que, en situaciones catastróficas, permite intervenir ante el empeoramiento de las condiciones clínicas del paciente, lo que favorece el aumento de la tasa de supervivencia y brinda seguridad. Objetivo catastróficas Método CentroOeste Centro Oeste Brasil 202 2021 Research etapas hospitalarios 10 7 inferencial problemas thinking Resultados organización fin diseño alineación construido Conclusión paciente 20 1 2

ABSTRACT Objective: to produce technology that promotes safe hospital care in catastrophic situations. Method: an applied study carried out in a public hospital located in Brazil's Midwest region, between September 2020 and August 2021, using Soft Design Science Research in seven stages: outlining the problem, with descriptive analysis of hospital indicators; explaining the problem as a specific set of requirements, through the application of scales with 108 health professionals and 75 nursing staff, and descriptive and inferential analysis; generalizing the problem, through a scope review to systematize a class of problems; structuring the components of the solution through a workshop guided by design thinking; comparing the specific problem and general requirements to align the solution; defining the solution; building the solution. Results: immersion in the problem revealed outcomes that heralded the worsening of patients' health conditions and the negative perception of workers and managers regarding the safety climate in catastrophic situations, accentuated by the nursing team's dissatisfaction with the support offered by the organization. The projection of this scenario was essential for the systematization of security-enhancing solutions already produced for this purpose, and for carrying out design-oriented experiments in alignment, structuring, prototyping and iteration of the prototype built. Conclusion: a Rapid Response Team has been set up which, in catastrophic situations, makes it possible to intervene when the patient's clinical condition worsens, which helps to increase the survival rate and promotes safety. Objective situations Method Brazils Brazil s region 202 2021 stages indicators 10 7 staff problems thinking Results patients teams team organization securityenhancing security enhancing purpose designoriented oriented alignment built Conclusion patient worsens 20 1 2

RESUMO Objetivo: produzir tecnologia propulsora de segurança do cuidado na atenção hospitalar em situações catastróficas. Método: pesquisa de natureza aplicada realizada em um hospital público situado na região centro-oeste, Brasil, entre os meses de setembro de 2020 a agosto de 2021, por meio da aplicação da Soft Design Science Research, em sete etapas: delineamento do problema, com análise descritiva de indicadores hospitalares; explicitação do problema como um conjunto específico de requisitos, mediante aplicação de escalas com 108 profissionais de saúde e 75 de enfermagem, e análise descritiva e inferencial; generalização do problema, através de revisão de escopo para sistematização de uma classe de problemas; estruturação dos componentes da solução por meio de workshop orientado pelo design thinking; comparação entre o problema específico e requisitos gerais para alinhamento da solução; definição da solução; construção da solução. Resultados: a imersão no problema evidenciou desfechos que anunciam o agravamento da condição de saúde dos pacientes e percepção negativa de trabalhadores e gestores em relação ao clima de segurança em situações catastróficas, acentuado pela insatisfação da equipe de enfermagem com o suporte oferecido pela organização. A projeção deste cenário foi essencial para sistematização de soluções potencializadoras de segurança já produzidas com esta finalidade, e para a realização de experimentações orientadas pelo design, em alinhamento, estruturação, prototipagem e iteração do protótipo construído. Conclusão: produziu-se um Time de Resposta Rápida que, em situações catastróficas, permite intervir frente ao agravamento de condições clínicas do paciente, o que favorece a ampliação da taxa de sobrevida e é propulsor de segurança. Objetivo catastróficas Método centrooeste, centrooeste centro oeste, oeste centro-oeste Brasil 202 2021 Research etapas hospitalares 10 7 inferencial problemas thinking Resultados organização finalidade construído Conclusão produziuse produziu se paciente 20 1 2

https://doi.org/10.1590/1980-265x-tce-2023-0335en

Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves

; Guimarães, Camila

; Rêgo, Jozelia

; Machado, Ketty Lysie Libardi Lira

; Miyamoto, Samira Tatiyama

; Burian, Ana Paula Neves

; Dias, Laiza Hombre

; Pretti, Flavia Zon

; Batista, Danielle Cristina Filgueira Alves

; Mill, José Geraldo

; Oliveira, Yasmin Gurtler Pinheiro de

; Gadelha, Carolina Strauss Estevez

; Gouveia, Maria da Penha Gomes

; Moulin, Anna Carolina Simões

; Souza, Bárbara Oliveira

; Aguiar, Laura Gonçalves Rodrigues

; Vieira, Gabriel Smith Sobral

; Grillo, Luiza Lorenzoni

; Lima, Marina Deorce de

; Pasti, Laís Pizzol

; Surlo, Heitor Filipe

; Faé, Filipe

; Moulaz, Isac Ribeiro

; Macabú, Mariana de Oliveira

; Ribeiro, Priscila Dias Cardoso

; Magalhães, Vanessa de Oliveira

; Aguiar, Mariana Freitas de

; Biegelmeyer, Erika

; Peixoto;, Flávia Maria Matos Melo Campos

; Kayser, Cristiane

; Souza, Alexandre Wagner Silva de

; Castro, Charlles Heldan de Moura

; Ribeiro, Sandra Lúcia Euzébio

; Telles, Camila Maria Paiva França

; Bühring, Juliana

; Lima, Raquel Lima de

; Santos, Sérgio Henrique Oliveira Dos

; Dias, Samuel Elias Basualto

; Melo, Natália Seixas de

; Sanches, Rosely Holanda da Silva

; Boechat, Antonio Luiz

; Sartori, Natália Sarzi

; Hax, Vanessa

; Dória, Lucas Denardi

; Rezende, Rodrigo Poubel Vieira de

; Baptista, Katia Lino

; Fortes, Natália Rodrigues Querido

; Melo, Ana Karla Guedes de

; Melo, Tâmara Santos

; Vieira, Rejane Maria Rodrigues de Abreu

; Vieira, Adah Sophia Rodrigues

; Kakehasi, Adriana Maria

; Tavares, Anna Carolina Faria Moreira Gomes

; Landa, Aline Teixeira de

; Costa, Pollyana Vitoria Thomaz da

; Azevedo, Valderilio Feijó

; Martins-Filho, Olindo Assis

; Peruhype-Magalhães, Vanessa

; Pinheiro, Marcelo de Medeiros

; Monticielo, Odirlei André

; Reis-neto, Edgard Torres Dos

; Ferreira, Gilda Aparecida

; Souza, Viviane Angelina de

; Teixeira-Carvalho, Andréa

; Xavier, Ricardo Machado

; Sato, Emilia Inoue

; Valim, Valeria

; Pileggi, Gecilmara Salviato

; Silva, Nilzio Antonio da

Advances in Rheumatology

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2024, Volume 64 elocation 58

Abstract: En | Text: En | PDF: En

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26

https://doi.org/10.1186/s42358-024-00397-5

Análise da percepção de médicos do Sistema Único de Saúde sobre o uso da teleinterconsulta em Campo Grande-MS, Brasil
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Menezes, Leonardo Lima de

; Souza, Maria Isabel de Castro de

; Simas, Keith Bullia da Fonseca

; Mueller, Vanessa

; Guimarães, Emilene dos Santos

; Berry, Maria Cardoso de Castro

; Marques, David Tebaldi

Ciência & Saúde Coletiva

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2024, Volume 29 N. 11 elocation e03352024

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Abstract This study aimed to analyze the perception of the use of teleconsultation by physicians of the Unified Health System in Campo Grande-MS, as an auxiliary tool for the care of SUS patients, addressing effectiveness, satisfaction and access to results, directed to physicians of different specialties. Of a total population of 127 professionals, 100 voluntarily participated in the survey. The results demonstrated that teleconsultation was perceived as advantageous, highlighting the exchange of knowledge (44.1%) and the reduction of waiting time (42.5%). Disadvantages included low investment in the operational structure (25.2%) and technical difficulties of communication (23.6%). Teleconsultation proved to be innovative, providing intense exchange of knowledge and reducing waiting time. Although it presents technical challenges, most physicians perceived it as effective and safe.

Resumen El presente estudio tuvo como objetivo analizar la percepción sobre el uso de la teleconsulta por parte de los médicos del Sistema Único de Salud de Campo Grande-MS, como herramienta auxiliar para la atención a los pacientes del SUS, abordando la efectividad, la satisfacción y el acceso a los resultados, dirigido a médicos de diferentes especialidades. De una población total de 127 profesionales, 100 participaron voluntariamente en la investigación. Los resultados demostraron que la teleconsulta fue percibida como ventajosa, destacándose el intercambio de conocimientos (44,1%) y la reducción del tiempo de espera (42,5%). Las desventajas incluyeron baja inversión en la estructura operativa (25,2%) y dificultades de comunicación técnica (23,6%). La teleconsulta demostró ser innovadora, proporcionando un intenso intercambio de conocimientos y reduciendo los tiempos de espera. Aunque presenta desafíos técnicos, la mayoría de los médicos lo percibieron como eficaz y seguro.

https://doi.org/10.1590/1413-812320242911.03352024

Comparison of Locked Plates and Blade Plates for Varus Osteotomy of the Proximal Femur by the Finite Element Method
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Ribeiro Filho, Wilisson

; Wolf, Eduardo Henrique Silva

; Santili, Claudio

; Akari, Miguel

; Freitas, Vanessa Guimarães de

; Doudement, Leonel Vieira

Revista Brasileira de Ortopedia

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2024, Volume 59 N. 1 Pages 107 - 118

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Objective: The present study compared the difference in load and pressure distribution behavior of the blade plate and locked plate for varus osteotomy of the proximal femur per the finite element method. Methods: Modeling was performed by scanning a medium-sized left femur with medial valgus deformity made of polyurethane. Results: The stiffness of the locked plate is higher compared with that of the blade plate. However, this difference was not significant. In addition, the locked plate has proximal locking screws to ensure that the bending moments on the screws are smaller during loading. Conclusion: In summary, both plates are well-established and effective. However, the study using the finite element method plays a fundamental role in understanding the load and pressure distribution of the implant. Moreover, it opens up new possibilities for further studies, including surgical proposals and customized implant materials. Objective Methods mediumsized medium sized polyurethane Results However significant addition loading Conclusion summary wellestablished well established effective Moreover studies materials

Resumo Objetivo: Testar a diferença do comportamento de distribuição de cargas e pressões da placa lâmina comparativamente com a placa bloqueada para osteotomia varizante do fêmur proximal através do método de elementos finitos. Métodos: A modelagem foi realizada através do escaneamento de um fêmur esquerdo com deformidade medial em valgo fabricado em poliuretano de tamanho médio. Resultados: Como resultados, pode-se inferir que a rigidez da placa bloqueada é maior do que a da placa lâmina. No entanto, essa diferença não foi significativa e, além disso, a placa bloqueada possui parafusos de travamento proximal para garantir que os momentos de flexão que agem nos parafusos sejam ainda menores durante o carregamento. Conclusão: Em síntese, ambos os materiais são consagrados e eficazes para serem utilizados, porém o estudo pelo método de elementos finitos apresenta papel importante para compreendermos a situação de distribuição de cargas e pressões do implante e abre novas possibilidades para novos estudos, como, por exemplo, o estudo da proposta cirúrgica e materiais a serem implantados de forma individual e personalizada. Objetivo Métodos médio Resultados resultados podese pode se entanto disso carregamento Conclusão síntese utilizados estudos como exemplo personalizada

https://doi.org/10.1055/s-0043-1775889

Internal corrosion prevention in slurry pipelines using nitrogen gas: a case study gas
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Torres, Ayron Silva Guimarães

; Lins, Vanessa de Freitas Cunha

; Mattioli, Gabriela Goes

; Brandao, Paulo Roberto Gomes

REM - International Engineering Journal

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2024, Volume 77 N. 2 elocation e210002

Abstract: En | Text: En | PDF: En

Abstract The transport capacity of the slurry pipelines is related to the internal roughness of the pipe. Thus, the application of corrosion protection methods is of fundamental importance, both in the operational phase and in times of temporary shutdown. In addition, corrosion also affects the service life of the duct. The studied pipeline was hibernated with nitrogen using the ABNT NBR 15280-2 standard as a reference and remained hibernated for 3.5 years. Chemical, mineralogical, and microstructural analyses were carried out on samples of materials removed from the pipeline interior during the hibernation period. The most striking phase found was magnetite, with botrioidal morphology, formed by the oxidation of steel in the pipeline. After reactivation, the pipeline was inspected by smart pigs with ultrasound and MFL technologies. It was found that the corroded regions are more concentrated in the initial kilometers of the sections, where important depths of corrosion were also observed, as well as higher rates of corrosion and erosion, which show the influence of the operational phase in the development of the pipeline corrosive process and wear. Thus, the application of the nitrogen hibernation process in long-distance pipelines proved to be feasible for long periods of time. However, improvements are suggested in this article to make the process more robust. pipe Thus importance shutdown addition duct 152802 15280 2 15280- 35 3 5 3. years Chemical mineralogical period magnetite morphology reactivation technologies sections observed erosion wear longdistance distance time However robust 1528 152 15 1

https://doi.org/10.1590/0370-44672021770002

EZH2 immunoexpression in pleomorphic adenoma and adenoid cystic carcinoma and clinicopathological features EZH
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NORONHA, Mariana Saturnino de

; VIANA, Karolina Skarlet Silva

; AGUIAR, Maria Cássia Ferreira de

; SQUARIZE, Cristiane Helena

; ABREU, Mauro Henrique Nogueira Guimarães de

; MENDONÇA, Elismauro Francisco

; BERNARDES, Vanessa de Fátima

Brazilian Oral Research

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2024, Volume 38 elocation e018

Abstract: En | Text: En | PDF: En

Abstract The aim of this study was to evaluate the expression of the EZH2 protein and describe the clinical and microscopic characteristics of adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA). The study included 16 ACC cases and 12 PA. All ACC and PA cases were positive for EZH2 and the ACC samples showed significantly higher EZH2 expression. The clinical and microscopic covariates were described in relation to EZH2 staining in ACC samples. The highest mean values of EZH2 were observed in cases with local metastasis, recurrence, perineural invasion, and predominantly cribriform growth pattern without solid areas. EZH2 is a potential marker of malignancy. EZH (ACC . (PA) 1 metastasis recurrence invasion areas malignancy (PA

https://doi.org/10.1590/1807-3107bor-2024.vol38.0018

Análise da percepção de médicos do Sistema Único de Saúde sobre o uso da teleinterconsulta em Campo Grande-MS, Brasil GrandeMS, GrandeMS Grande MS, MS Grande-MS
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Menezes, Leonardo Lima de

; Souza, Maria Isabel de Castro de

; Simas, Keith Bullia da Fonseca

; Mueller, Vanessa

; Guimarães, Emilene dos Santos

; Berry, Maria Cardoso de Castro

; Marques, David Tebaldi

Ciência & Saúde Coletiva

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2024, Volume 29 N. 11 elocation e03352024

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumo O presente estudo visou analisar a percepção da utilização da teleinterconsulta por médicos do Sistema Único de Saúde em Campo Grande-MS, como ferramenta auxiliar para o atendimento de pacientes do SUS, abordando efetividade, satisfação e acesso a resultados, direcionados a médicos de diferentes especialidades. De uma população total de 127 profissionais, 100 participaram voluntariamente da pesquisa. Os resultados demonstraram que a teleinterconsulta foi percebida como vantajosa, destacando-se o intercâmbio de saberes (44,1%) e a redução do tempo de espera (42,5%). Desvantagens incluíram baixo investimento na estrutura operacional (25,2%) e dificuldades técnicas de comunicação (23,6%). A teleinterconsulta mostrou-se inovadora, proporcionando intensa troca de conhecimentos e redução do tempo de espera. Embora apresente desafios técnicos, a maioria dos médicos a percebeu como efetiva e segura. GrandeMS, GrandeMS Grande MS, MS Grande-MS SUS efetividade especialidades 12 profissionais 10 pesquisa vantajosa destacandose destacando se 44,1% 441 44 1 (44,1% 42,5%. 425 42,5% . 42 5 (42,5%) 25,2% 252 25 2 (25,2% 23,6%. 236 23,6% 23 6 (23,6%) mostrouse mostrou inovadora técnicos segura 44,1 4 (44,1 42,5 (42,5% 25,2 (25,2 23,6 (23,6% 44, (44, 42, (42,5 25, (25, 23, (23,6 (44 (42, (25 (23, (4 (42 (2 (23 (

https://doi.org/10.1590/1413-812320242911.03352024

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 N. 7 elocation s00441788586

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

10.

Inconsistencies in the quality of the information on package inserts of medicines for veterinary use commercialized in Brazil
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Thomazini, Vanessa Cola

; Mantovanelli, Vitória Ribeiro

; Dias, Marcela Saager

; Ávila, Letycia Fernandes Franklin

; Rocha, Vinycius Fernandes da

; Guimarães, Nayhara Madeira

; Cunha, Gabriel Mendes da

; Giuberti, Cristiane dos Santos

; Villanova, Janaína Cecília Oliveira

Brazilian Journal of Pharmaceutical Sciences

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2024, Volume 60 elocation e24041

Abstract: En | Text: En | PDF: En

Abstract This study examines the adequacy, readability, and quality of the information provided on package inserts for veterinary medicines in Brazil. It aims to identify the essential information required in these documents and assess non-compliance with regulatory standards. Initially, a documentary analysis was conducted to identify mandatory information as per Federal Decree No. 5,053/2004 and Normative Instruction No. 26/2009 of the Ministry of Agriculture, Livestock and Supply. Subsequently, 256 package inserts were analyzed to evaluate their suitability using descriptive quantitative analysis. This analysis showed a lack of essential technical and scientific information, necessary for the rational use of veterinary medicines. Mandatory elements supporting the correct use of veterinary medicines and essential information, such as a qualitative description of excipients, equivalence factors, the mass of active pharmaceutical ingredient per volume (when applicable), and information about the customer service center, were absent from these documents. This study found at least one non-conformity in the 252 evaluated package inserts. These findings underscore the significant lack of adherence to established rules and the low quality of technical-scientific information, reducing the comprehension of both prescribers and owners. The authors highlight the need for regulatory agencies to review and improve the guidelines that govern the format and content of package inserts. adequacy readability Brazil noncompliance non compliance standards Initially No 50532004 5 053 2004 5,053/200 262009 26 2009 26/200 Agriculture Supply Subsequently 25 excipients factors when applicable, applicable , applicable) center nonconformity conformity technicalscientific owners 5053200 05 200 5,053/20 26200 2 26/20 505320 0 20 5,053/2 2620 26/2 50532 5,053/ 262 26/ 5053 5,053 505 5,05 50 5,0 5,

https://doi.org/10.1590/s2175-97902024e24041

11.

Brazilian Society of Otology task force - Otosclerosis: evaluation and treatment Otosclerosis
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Silva, Vagner Antonio Rodrigues

; Pauna, Henrique Furlan

; Lavinsky, Joel

; Guimarães, Guilherme Corrêa

; Abrahão, Nicolau Moreira

; Massuda, Eduardo Tanaka

; Vianna, Melissa Ferreira

; Yudi Ikino, Cláudio Márcio

; Santos, Vanessa Mazanek

; Polanski, José Fernando

; Silva, Maurício Noschang Lopes da

; Sampaio, André Luiz Lopes

; Zanini, Raul Vitor Rossi

; Lourençone, Luiz Fernando Manzoni

; Denaro, Mariana Moreira de Castro

; Calil, Daniela Bortoloti

; Chone, Carlos Takahiro

; Castilho, Arthur Menino

Brazilian Journal of Otorhinolaryngology

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oct 2023, Volume 89 N. 5 elocation 101303

Abstract: En | Text: En | PDF: En

Abstract Objectives: To review and provide evidence-based recommendations for the diagnosis and treatment of otosclerosis. Methods: Task force members were educated on knowledge synthesis methods, including electronic database search, review and selection of relevant citations, and critical appraisal of selected studies. Articles written in English or Portuguese on otosclerosis were eligible for inclusion. The American College of Physicians’ guideline grading system and the American Thyroid Association’s guideline criteria were used for critical appraisal of evidence and recommendations for therapeutic interventions. Results: The topics were divided into 2 parts: 1) Diagnosis – audiologic and radiologic; 2) Treatment – hearing AIDS, pharmacological therapy, stapes surgery, and implantable devices - bone-anchored devices, active middle ear implants, and Cochlear Implants (CI). Conclusions: The pathophysiology of otosclerosis has not yet been fully elucidated, but environmental factors and unidentified genes are likely to play a significant role in it. Women with otosclerosis are not at increased risk of worsening clinical condition due to the use of contraceptives or during pregnancy. Drug treatment has shown little benefit. If the patient does not want to undergo stapedotomy, the use of hearing aids is well indicated. Implantable systems should be indicated only in rare cases, and the CI should be indicated in cases of profound deafness. Objectives evidencebased based Methods methods search citations studies inclusion Physicians Associations Association s interventions Results parts 1 radiologic AIDS therapy surgery boneanchored bone anchored implants CI. . (CI) Conclusions elucidated it pregnancy benefit stapedotomy deafness (CI

https://doi.org/10.1016/j.bjorl.2023.101303

12.

Conexões internacionais e feixes de poder no contexto das novas agendas urbanas
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Marx, Vanessa

; Guimarães, Roberta

Cadernos Metrópole

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aug 2023, Volume 25 N. 57 Pages 359 - 370

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/2236-9996.2023-5700

13.

Tensionamentos no cuidado em Saúde Mental relacionados ao uso de Substâncias Psicoativas: dificuldades identificadas por profissionais da saúde pública
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Oliveira, Vanessa

; Guimarães, Denise Alves

; Gama, Carlos Alberto Pegolo da

; Coelho, Vívian Andrade Araújo

; Coelho, Flávia borba Paulino

Saúde em Debate

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jun 2023, Volume 47 N. 137 Pages 133 - 145

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Analisaram-se, na percepção de profissionais da Atenção Primária à Saúde (APS), as dificuldades no cuidado em Saúde Mental relacionadas ao uso de Substâncias Psicoativas (SPA), à luz de reflexões sobre os tensionamentos presentes na saúde pública no que se refere ao seu uso. Foi conduzido estudo exploratório qualitativo em 11 municípios da Macrorregião de Saúde Oeste do estado de Minas Gerais, com entrevistas semiestruturadas e Grupos Focais com 145 profissionais da APS. O material foi analisado a partir do referencial de Análise de Conteúdo. As principais dificuldades identificadas estavam relacionadas à organização e à gestão do trabalho em saúde, ao estigma sobre usuários com demandas relacionadas ao uso de SPA, à falta de reflexões e práticas em saúde que considerem a realidade dos usuários em uso de SPA, à ‘cultura da medicação’ e à desarticulação da Rede de Atenção Psicossocial. É fundamental o desenvolvimento de políticas e práticas que permitam aos trabalhadores e às estruturas de saúde uma maior reflexão acerca da relação entre o uso de SPA e as possibilidades de lidar com o sofrimento, expresso de diferentes formas pelos usuários dos serviços de saúde.

ABSTRACT Difficulties found by healthcare professionals working at Primary Health Care (PHC) with respect to Mental Healthcare issues regarding Psychoactive Substances (PS) were analyzed considering a tensioning which pervaded those issues. An exploratory qualitative study was performed in 11 municipalities of the west macroregion of Minas Gerais state. Semi-structured interviews and focal groups with 145 PHC professionals. Data was analyzed through content analysis. The most relevant difficulties were related to health work organization and management, the stigma against users with demands related do the use of PS, the lack of reflections health practices which consider the user’s reality, the ‘medicine culture’ and a disjointed Psychosocial Attention Network. It is fundamental to develop policies and practices that allow workers and health structures to reflect more on the relationship between PS use and possibilities to cope with suffering, expressed in different ways by healthcare users.

https://doi.org/10.1590/0103-1104202313709

14.

Development and validation of the clinical report form for nodular thyroid pathologies
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Neto, Vanessa

; Esteves-Ferreira, Sara

; Inácio, Isabel

; Alves, Márcia

; Dantas, Rosa

; Azevedo, Teresa

; Guimarães, Joana

; Herdeiro, Maria Teresa

; Nunes, Alexandra

Archives of Endocrinology and Metabolism

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feb 2023, Volume 67 N. 1 Pages 136 - 142

Abstract: En | Text: En | PDF: En

Abstract Objectives: The aim of this study is to develop and validate a novel clinical report form in the format of a structured interview to enable the characterization of the Portuguese population of the Baixo Vouga region with different subtypes of nodular thyroid pathologies (NTyPs). Materials and methods: A structured interview was developed and to the best of our knowledge, this is the first structured interview built and validated for that purpose in Portugal. Results: This structured interview enables the identification of possible correlations between each subtype of nodular lesions and sociodemographic data, consumption habits and lifestyle, endocrine history, and family predisposition. Conclusion: The novel structured interview will simultaneously, enable a detailed characterization of the group of patients with nodular thyroid lesions and will support future metabolomic studies. Objectives NTyPs. NTyPs . (NTyPs) methods knowledge Portugal Results data lifestyle history predisposition Conclusion simultaneously studies (NTyPs

https://doi.org/10.20945/2359-3997000000534

15.

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal SISBIOTADiptera SISBIOTA Network longterm long term Amazon Cerrado
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists. SISBIOTABRASIL SISBIOTA BRASIL threeyear year multimilliondollar multimillion dollar endangeredunderstudied endangered understudied Brazil flora processes premise Sul Rondônia forest Savannah, Savannah , Savannah) relevance surveys Therefore literature lands 9 2 researchers postdocs students technicians 300000 300 000 300,00 60 ~6 Here 4 treated 2130 130 2,13 51 altogether 29 combined respectively Overall 1 speciesrich rich Tachinidae Cecidomyiidae Tabanidae Psychodidae Sarcophagidae Stratiomyidae Bombyliidae Syrphidae Tephritidae Asilidae Mycetophilidae Muscidae Dolichopodidae Chloropidae far 11 taxonomic phylogenetic specialists 30000 30 00 300,0 6 ~ 213 13 2,1 5 3000 3 0 300, 21 2,

https://doi.org/10.1590/1806-9665-rbent-2023-0051

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