Objective: Patients with chronic hepatitis C (CHC) have a poorer quality of life than those with other chronic liver diseases. However, some of the factors that determine health-related quality of life (HRQOL) in these patients, such as the degree of liver fibrosis, are still controversial. Therefore, the aim of the present study was to investigate the impact of CHC on HRQOL by conducting clinical, psychiatric, and sociodemographic evaluations. Methods: One hundred and twenty-four consecutive patients attending a referral center for hepatitis were evaluated using the Mini-International Neuropsychiatry Interview, the Hamilton Depression Rating Scale, the Hospital Anxiety and Depression Scale, and the Medical Outcomes Study 36-Item Short-Form Health Survey. Multiple linear regression analyses were used to quantify independent associations between HRQOL and the clinical, psychiatric, and sociodemographic variables of interest. Results: Reduced HRQOL was independently associated with major depressive disorder (MDD) and with elevated levels of alanine aminotransferase, but was not associated with hepatic cirrhosis. Conclusions: MDD rather than the grade of liver fibrosis was strongly associated with HRQOL impairment in patients with CHC. These findings highlight that, in patients with CHC, the psychological effects of the disease deserve more attention and the implementation of integrated medical, psychiatric, and psychological care may be helpful.

A abordagem antropológica foi empregada para investigar o universo de representações (maneiras de pensar) e comportamentos (maneiras de agir) associados à doença de Chagas, por um grupo de trabalhadores de um serviço público de Belo Horizonte (infectados/não infectados). Procurou-se também avaliar as repercussões deste universo de representações e comportamentos sobre a vida dos indivíduos infectados. A coleta e a análise dos dados, inspirou-se no modelo dos "sistemas de signos, significados e ações", elaborado por Corin et al. (1989, 1992). Foram entrevistados 16 informantes chave, selecionados entre os trabalhadores soro-positivos e 12 entre os trabalhadores soro-negativos, com o objetivo de comparar as maneiras de pensar e agir, predominantes nesses dois grupos. A análise dos dados, permitiu identificar diversos elementos do contexto que vêm maximizar as limitações impostas pela doença de Chagas, e que devem ser levados em conta no planejamento de campanhas educativas e na elaboração de modelos de atenção ao paciente chagásico.

An anthropological approach was employed to investigate the universe of representations (ways of thinking) and behaviors (ways of acting) associated with Chagas disease in a group of public service workers in Belo Horizonte (both infected and not infected with Trypanosoma cruzi). An attempt was also made to evaluate the repercussions of this universe of representations and behaviors on the lives of the infected individuals. The collection and analysis of the data followed the "systems of signs, meanings, and actions" model developed by Corin et al. (1989, 1992). Sixteen seropositive and 12 seronegative workers were interviewed to compare their ways of thinking and acting towards the disease. Data analysis allowed identification of diverse elements within a context that maximized the limitations imposed by Chagas disease. These should be taken into account in the planning of educational campaigns and elaboration of health care models for Chagas patients.

A abordagem antropológica foi empregada para investigar o universo de representações (maneiras de pensar) e comportamentos (maneiras de agir) associados à doença de Chagas, por um grupo de trabalhadores de um serviço público de Belo Horizonte (infectados/não infectados). Procurou-se também avaliar as repercussões deste universo de representações e comportamentos sobre a vida dos indivíduos infectados. A coleta e a análise dos dados, inspirou-se no modelo dos "sistemas de signos, significados e ações", elaborado por Corin et al. (1989, 1992). Foram entrevistados 16 informantes chave, selecionados entre os trabalhadores soro-positivos e 12 entre os trabalhadores soro-negativos, com o objetivo de comparar as maneiras de pensar e agir, predominantes nesses dois grupos. A análise dos dados, permitiu identificar diversos elementos do contexto que vêm maximizar as limitações impostas pela doença de Chagas, e que devem ser levados em conta no planejamento de campanhas educativas e na elaboração de modelos de atenção ao paciente chagásico.

An anthropological approach was employed to investigate the universe of representations (ways of thinking) and behaviors (ways of acting) associated with Chagas disease in a group of public service workers in Belo Horizonte (both infected and not infected with Trypanosoma cruzi). An attempt was also made to evaluate the repercussions of this universe of representations and behaviors on the lives of the infected individuals. The collection and analysis of the data followed the "systems of signs, meanings, and actions" model developed by Corin et al. (1989, 1992). Sixteen seropositive and 12 seronegative workers were interviewed to compare their ways of thinking and acting towards the disease. Data analysis allowed identification of diverse elements within a context that maximized the limitations imposed by Chagas disease. These should be taken into account in the planning of educational campaigns and elaboration of health care models for Chagas patients.