ABSTRACT BACKGROUND: Down syndrome (DS) is a non-rare genetic condition that affects approximately 1 in every 800 live births worldwide. Further, it is associated with comorbidities, anatomical alterations of the respiratory tract, and immunological dysfunctions that make individuals more susceptible to respiratory infections. OBJECTIVE: To systematize the current scientific knowledge about the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among individuals with DS. DESIGN AND SETTING: This integrative review was conducted at the Universidade Federal de São Carlos, São Paulo, Brazil. METHODS: This review was conducted in the following databases: the Virtual Health Library (Biblioteca Virtual em Saúde, BVS), PubMed, and Web of Science, using MeSH descriptors. The search included English or Portuguese studies published between January 1, 2020, and October 14, 2022. RESULTS: A total of 55 articles from 24 countries were selected, comprising 21 case-control or cohort studies, 23 case reports or series, and 11 narrative reviews or opinion studies. The articles were grouped into five categories: previous comorbidities, coronavirus disease 2019 (COVID-19) clinical features and evolution, cytokine storm and interleukins, living in institutions as a risk factor, and behavioral actions as a protective factor against SARS-CoV-2 infection. CONCLUSION: Individuals with DS are more susceptible to COVID-19 infection due to variables such as previous comorbidities, immunological factors, and their habitable environments. These aspects confer a higher risk of infection and an unfavorable clinical course. The precise pathways involved in the pathophysiology of COVID-19 in individuals with DS are not clear, thus requiring further studies. SYSTEMATIC REVIEW REGISTRATION: The Open Science Framework registered the research protocol (https://osf.io/jyb97/). BACKGROUND (DS nonrare non rare 80 worldwide Further comorbidities tract infections OBJECTIVE SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 SETTING Carlos Paulo Brazil METHODS databases Biblioteca Saúde BVS, BVS , BVS) PubMed descriptors 2020 14 2022 RESULTS 5 selected casecontrol control series categories 201 COVID19 COVID 19 (COVID-19 evolution interleukins SARS-CoV- CONCLUSION COVID-1 factors environments course clear REGISTRATION https//osf.io/jyb97/. httpsosfiojyb97 httpsosfiojyb https //osf.io/jyb97/ . osf io jyb97 jyb (https://osf.io/jyb97/) 8 (SARS-CoV- 202 20 COVID1 (COVID-1 SARS-CoV COVID- https//osf.io/jyb97/ httpsosfiojyb9 osfiojyb97 osfiojyb //osf.io/jyb97 jyb9 (https://osf.io/jyb97/ (SARS-CoV (COVID- https//osf.io/jyb97 osfiojyb9 //osf.io/jyb9 (https://osf.io/jyb97 (COVID https//osf.io/jyb9 //osf.io/jyb (https://osf.io/jyb9 https//osf.io/jyb (https://osf.io/jyb

RESUMO Objetivo: analisar a abordagem fonoaudiológica por meio da telessaúde em pacientes com disfagia e determinar as aplicações e efeitos desta prática. Métodos: para seleção foram utilizados os descritores: Telerehabilitation, Telemedicine, "Remote Consultation", "Delivery of Health Care", "Distance Counseling", "Therapy, Computer-Assisted", “Speech-Language Pathology”, "Speech Therapy", "Deglutition Disorders", Dysphagia, “Bottle Feeding" e "Enteral Nutrition” nas bases de dados PubMed, MedLine, Scopus e Web of Science e na literatura cinzenta, por meio do Google Acadêmico e ProQuest. Foram selecionados estudos sem delimitação de tempo, nas línguas português, inglês e espanhol, que descrevessem a aplicabilidade e/ou efeitos da telessaúde na prática fonoaudiológica junto à pacientes com alteração da deglutição/disfagia, sem restrição de sexo e idade. Para análise considerou-se: nível de evidência científica e recomendação, modalidade de telessaúde, objetivos, métodos e resultados/conclusão. Revisão da Literatura: foram encontrados 490 artigos e, após exclusão de duplicatas, análise dos títulos, resumos e leitura completa dos artigos, 22 estudos foram selecionados. Os artigos foram classificados nas modalidades da telessaúde: tele-educação, telediagnóstico, teleconsultoria, telerregulação e telemonitoramento. Conclusão: as modalidades de telessaúde descritas tiveram grande potencial para promover melhoras significativas em pacientes com alteração de deglutição/disfagia, sugerindo-as como viáveis para serviços fonoaudiológicos. Entre elas, a teleconsulta foi a menos explorada. Objetivo Métodos descritores Telerehabilitation Telemedicine Remote Consultation, Consultation , Consultation" Delivery Care, Care Care" Distance Counseling, Counseling Counseling" Therapy, Therapy "Therapy ComputerAssisted, ComputerAssisted Computer Assisted Computer-Assisted" SpeechLanguage Speech Language Pathology, Pathology Pathology” Therapy" Deglutition Disorders, Disorders Disorders" Dysphagia Bottle Feeding Enteral Nutrition PubMed MedLine cinzenta ProQuest tempo português espanhol eou ou deglutiçãodisfagia deglutição deglutição/disfagia idade considerouse considerou se considerou-se recomendação objetivos resultadosconclusão resultados conclusão resultados/conclusão Literatura 49 duplicatas títulos 2 teleeducação, teleeducação tele educação, educação tele-educação telediagnóstico teleconsultoria telemonitoramento Conclusão sugerindoas sugerindo fonoaudiológicos elas explorada Computer-Assisted 4

ABSTRACT Purpose: to analyze the telehealth speech therapy approach in patients with oropharyngeal dysphagia and determine the applications and effects of this practice. Methods: the following descriptors were used for selection: Telerehabilitation, Telemedicine, "Remote Consultation", "Healthcare Delivery", "Distance Counseling", "Therapy, Computer-Assisted", "Speech-Language Pathology", "Speech Therapy", "Swallowing Disorders", Dysphagia, “Bottle Feeding" and "Enteral Nutrition” in PubMed, MedLine, Scopus and Web of Science databases and in the gray literature, by Google Scholar and ProQuest. Studies were selected without time limits, in Portuguese, English and Spanish, that described the applicability and/or effects of telehealth in speech therapy practice in patients with swallowing disorders/dysphagia, regardless of gender and age. For analysis, the following were considered: level of scientific evidence and recommendation, telehealth modality, objectives, methods and results/conclusion. Literature Review: 490 articles were found and, after exclusion of duplicates, analysis of titles, abstracts and reading of full articles, 22 studies were selected. The articles were classified into telehealth modalities: tele-education, telediagnosis, teleconsulting, teleregulation and telemonitoring. Conclusion: the telehealth modalities described had a great potential to promote significant improvements in patients presented with swallowing disorders/dysphagia, suggesting them as viable for speech therapy services. Among them, teleconsultation was the least addressed. Purpose Methods selection Telerehabilitation Telemedicine Remote Consultation, Consultation , Consultation" Healthcare Delivery, Delivery Delivery" Distance Counseling, Counseling Counseling" Therapy, Therapy "Therapy ComputerAssisted, ComputerAssisted Computer Assisted Computer-Assisted" SpeechLanguage Speech Language Pathology, Pathology Pathology" Therapy" Swallowing Disorders, Disorders Disorders" Dysphagia Bottle Feeding Enteral Nutrition PubMed MedLine literature ProQuest limits Portuguese Spanish andor or disordersdysphagia disorders disorders/dysphagia age considered recommendation modality objectives resultsconclusion results conclusion results/conclusion Review 49 duplicates titles 2 teleeducation, teleeducation tele education, education tele-education telediagnosis teleconsulting telemonitoring Conclusion services addressed Computer-Assisted 4

Abstract The total cost of processes that use lipases can be reduced by using the mycelium or not purified crude extract with lipolytic activity. These catalysts can be used without complex purification and can show desirable properties to emerging applications like hydrolysis and biotransformation of vegetable oils. To explore the potential of multiple forms of lipases (produced by the same filamentous fungus species), this work investigated intracellular and extracellular lipases produced by Trichoderma koningii (intracellular lipases were never studied), Penicillium spp. F02 (isolated from industrial grease trap) and Aspergillus niger. For this, batch fermentations were conducted for 96h using olive oil as a carbon source. The submerged culture was interrupted with vacuum filtration to isolate the mycelium and crude extract. The lipolytic activities were determined by the hydrolysis method of olive oil. The best results were obtained for intracellular activity with T. koningii (81.5 U/g of dry biomass) and for extracellular activity with A. niger (10.6 U/mL of crude extract). Both were attained in 96h of fermentation. T. koningii showed an accumulation of intracellular lipases and a depreciated extracellular activity in the initial 24 hours, which can be reasonable indications that there is strong retention of lipases in the mycelium. Statistical analysis within the range of 37°C to 44°C associated with pH from 7.8 to 8.0 favored the activity of lipases from T. koningii. All these findings are promising for future studies in the enzymatic synthesis of biodiesel with lipases (intracellular and extracellular) from T. koningii. oils species, species , species) studied, studied studied) spp F F0 isolated trap h source T 81.5 815 81 5 (81. Ug U g biomass A 10.6 106 10 6 (10. UmL mL . extract) fermentation 2 hours 37C C 37 44C 44 78 7 8 7. 80 0 8. 81. (81 10. 1 (10 3 4 (8 (1 (

Abstract At low concentrations used for in-office bleaching gels, such as 6% HP, gingival barrier continues to be performed. If we take into account that, in the at-home bleaching technique, no barrier is indicated, it seems that the use of a gingival barrier fails to make much sense when bleaching gel in low concentration is used for in-office bleaching. Objective This double-blind, split-mouth, randomized clinical trial evaluated the gingival irritation (GI) of in-office bleaching using 6% hydrogen peroxide (HP) with and without a gingival barrier in adolescents, as well as color change and the impact of oral condition on quality of life. Methodology Overall, 60 participants were randomized into which side would or would not receive the gingival barrier. In-office bleaching was performed for 50 minutes with 6% HP in three sessions. The absolute risk and intensity of GI were assessed with a visual analogue scale. Color change was assessed using a digital spectrophotometer and color guides. The impact of oral condition on quality of life was assessed using the Brazilian version of the Oral Health Impact Profile (α=0.05). Results The proportion of patients who presented GI for the “with barrier” group was 31.6% and for the “without barrier” group, 30% (p=1.0). There is an equivalence for the evaluated groups regarding GI intensity (p<0.01). Color change was detected with no statistical differences (p>0.29). There was a significant impact of oral condition on quality of life after bleaching (p<0.001). Conclusions The use or not of the gingival barrier for in-office bleaching with 6% HP was equivalent for GI, as well as for bleaching efficacy, with improvement in the impact of oral condition on quality of life. inoffice office gels 6 athome at home technique indicated doubleblind, doubleblind double blind, blind double-blind splitmouth, splitmouth split mouth, mouth split-mouth (GI (HP adolescents Overall Inoffice In 5 sessions scale guides α=0.05. α005 α α=0.05 . 0 05 (α=0.05) 316 31 31.6 30 p=1.0. p10 p p=1.0 1 (p=1.0) p<0.01. p001 p<0.01 01 (p<0.01) p>0.29. p029 p>0.29 29 (p>0.29) p<0.001. p0001 p<0.001 001 (p<0.001) efficacy α00 α=0.0 (α=0.05 3 31. p1 p=1. (p=1.0 p00 p<0.0 (p<0.01 p02 p>0.2 2 (p>0.29 p000 p<0.00 00 (p<0.001 α0 α=0. (α=0.0 p=1 (p=1. p0 p<0. (p<0.0 p>0. (p>0.2 (p<0.00 α=0 (α=0. p= (p=1 p<0 (p<0. p>0 (p>0. α= (α=0 (p= p< (p<0 p> (p>0 (α= (p (p< (p> (α

Resumo Antecedentes O StepWatch Activity Monitor (SAM) é utilizado para medir a mobilidade de pacientes hemiparéticos crônicos e a escala Life Space Assessment (LSA) avalia o deslocamento de pacientes hemiparéticos em diferentes contextos por meio de autorrelato. Não foram encontrados estudos que tenham aplicado a LSA remotamente nem que a correlacionam com o número de passos mensurados pelo SAM. Objetivo Avaliar as propriedades de medida da LSA aplicada remotamente e avaliar a correlação entre o escore da escala LSA e o número de passos mensurados pelo SAM em pacientes com hemiparesia crônica pós-AVC. Métodos Dezenove participantes responderam a LSA remotamente e, posteriormente, presencialmente. O SAM mediu os passos dados pelos participantes durante um período de três dias consecutivos. A correlação entre a LSA e o SAM foi realizada por meio da correlação de Pearson. As propriedades de medida calculadas da LSA aplicada remotamente foram o coeficiente de correlação intraclasse (ICC), alfa de Cronbrach, erro do padrão de medida (SEM) e menor diferença real (SRD). Resultados A reprodutibilidade da escala LSA entre as aplicações remotas e presenciais foi considerada excelente com ICC = 0,85 (IC 95% 0,62-0,94); SEM = 8,4; SRD = 23,2 e alfa de Cronbrach = 0,85. A correlação entre SAM e a LSA foi positiva, considerada moderada (r = 0,51) e significativa (p= 0,025). Conclusão A LSA é uma medida reprodutível para pacientes hemiparéticos crônicos pós-AVC mesmo se aplicada remotamente e pode ser usada como uma medida remota de mobilidade em ambiente real para pessoas com hemiparesia crônica após AVC. (SAM (LSA autorrelato pósAVC. pósAVC pós AVC posteriormente presencialmente consecutivos Pearson ICC, , (ICC) (SEM SRD. . (SRD) 085 0 85 0,8 IC 95 0,620,94 062094 0,62 0,94 62 94 0,62-0,94) 8,4 84 8 4 232 23 2 23, positiva r 0,51 051 51 p= p (p 0,025. 0025 0,025 025 0,025) (ICC (SRD 08 0, 9 620 0,620,9 06209 062 0,6 094 0,9 6 0,62-0,94 8, 0,5 05 5 002 0,02 02 0,620, 0620 06 09 0,62-0,9 00 0,0 0,620 0,62-0, 0,62-0 0,62-

Abstract Background StepWatch Activity Monitor (SAM) is used to measure the mobility of chronic hemiparetic patients and the Life Space Assessment (LSA) scale was developed to assess the displacement of hemiparetic patients in different contexts through self-reporting. Studies that apply the LSA remotely and correlate it with the number of steps measured by the SAM were not found. Objective To evaluate the measurement properties of the LSA applied remotely and to evaluate the correlation between the LSA scale score and the number of steps measured by the SAM in post-stroke chronic hemiparetic patients. Methods Nineteen patients participated in the study. The LSA scale was applied remotely and later, face to face. The SAM measured the steps taken by the participants over a period of three consecutive days. The correlation between the LSA and the SAM was performed using Pearson's correlation. The measurement properties calculated of remote LSA were the intraclass correlation coefficient (ICC), Cronbrach's alpha, standard error of measurement (SEM), and smallest real difference (SRD). Results The reproducibility of the LSA scale between remote and face-to-face applications was considered excellent with ICC = 0.85 (IC 95% 0.62-0.94); SEM = 8.4; SRD = 23.2, and Cronbach's alpha = 0.85. The correlation between SAM and LSA was positive, considered moderate (r = 0.51) and significant (p = 0.025). Conclusion The LSA is a reproducible measure for post-stroke chronic hemiparetic patients even if applied remotely and can be used as a remote measurement for mobility in a real-world environment for people with chronic hemiparesis after stroke. (SAM (LSA selfreporting. selfreporting self reporting. reporting self-reporting found poststroke post stroke study later days Pearsons Pearson s ICC, , (ICC) Cronbrachs Cronbrach SEM, (SEM) SRD. . (SRD) facetoface 085 0 85 0.8 IC 95 0.620.94 062094 0.62 0.94 62 94 0.62-0.94) 8.4 84 8 4 232 23 2 23.2 Cronbachs Cronbach positive r 0.51 051 51 p 0.025. 0025 0.025 025 0.025) realworld world (ICC (SEM (SRD 08 0. 9 620 0.620.9 06209 062 0.6 094 0.9 6 0.62-0.94 8. 23. 0.5 05 5 002 0.02 02 0.620. 0620 06 09 0.62-0.9 00 0.0 0.620 0.62-0. 0.62-0 0.62-

RESUMO: O lúpulo é cultivado principalmente para o mercado cervejeiro devido à rica composição química que confere aroma e amargor à cerveja. O Brasil é um dos maiores produtores e consumidores de cerveja do mundo e um dos maiores importadores de lúpulo. Há crescente demanda e interesse na produção de lúpulo para abastecimento interno; porém, como essa cultura é originária de clima temperado e do Hemisfério Norte, é importante a realização de pesquisas que descrevam o desenvolvimento do lúpulo em clima tropical para fornecer informações sobre seu cultivo no Brasil, bem como determinar seu comportamento em cultivo orgânico cultivo. Adotou-se o delineamento em blocos ao acaso, e os tratamentos consistiram em dois sistemas de cultivo, convencional e orgânico, para a variedade Hallertau Mittelfrueh, com quatro blocos e três plantas por parcela. Análises de trocas gasosas de plantas sob ambos os sistemas de cultivo foram realizadas para obter medidas de A, gs, Ci, E, WUE e A/Ci, análises morfométricas e de produção também foram realizadas. Em comparação com as plantas do sistema orgânico, as plantas do cultivo convencional apresentaram maior eficiência fotossintética. No entanto, as práticas adotadas no sistema de cultivo orgânico proporcionaram maior capacidade produtiva às plantas. RESUMO interno porém Norte Adotouse Adotou se acaso Mittelfrueh parcela A gs Ci E ACi A/Ci fotossintética entanto

ABSTRACT: Hops are grown mainly for the brewing market due to the rich chemical composition that gives beer aroma and bitterness. Brazil is one of the largest beer producers and consumers in the world and one of the largest hop importers. There is growing demand and interest in producing hops for domestic supply; however, as this crop originates from a temperate climate and the Northern Hemisphere, it is important to carry out research that describes the development of hops in a tropical climate to provide information on its cultivation in Brazil, as well as to determine its behavior in organic cultivation. A randomized block design was adopted, the treatments consisted of two cropping systems, conventional and organic, for Hallertau Mittelfrueh variety cultivation, with four blocks and three plants per plot. Gas exchange analyzes of plants under both cultivation systems were performed to obtain measurements of A, g s , Ci, E, WUE and A/Ci, morphometric and yield analyzes were also carried out. In comparison with the plants of the organic system, the plants of the conventional cultivation had greater photosynthetic efficiency; however, the practices adopted in the organic cultivation system provided the plants with greater productive capacity. ABSTRACT bitterness importers supply however Hemisphere plot Ci E ACi A/Ci efficiency capacity

ABSTRACT The wet beneficiation process of ornamental stone generates waste in the form of sludge that, after drying, becomes a non-biodegradable fine powder. Its improper disposal can lead to various negative environmental impacts. Therefore, new destinations for waste should be evaluated in search of innovation and sustainability. In Brazil, this issue is of particular interest since the country stands out globally as one of the largest producers of ornamental stone, generating significant quantities of waste annually. Thus, mortars with replacement percentages (5, 10, 15, and 20 wt.%) of Portland cement (PC) by ornamental stone waste (OSW) were analyzed as supplementary cementitious material (SCM). The analysis included compressive strength tests, ultrasonic pulse velocity (UPV) at 7- and 28-day curing, X-ray diffraction, and a simplified carbon dioxide (CO2) emissions analysis. The results indicated that the partial replacement of PC by OSW up to 20% resulted in compressive strengths at 28 days statistically equal to the control sample, which can be attributed to the formation of AFm phases. When analyzing the CO2 emissions of the samples, higher substitution percentages were associated with lower reported emissions, reaching a reduction of 61.4% when comparing the 20% replacement with the reference. drying nonbiodegradable non biodegradable powder impacts Therefore sustainability Brazil annually Thus 5, 5 (5 10 15 2 wt.% wt (PC (OSW SCM. SCM . (SCM) tests UPV (UPV 7 28day day curing Xray X ray diffraction CO (CO2 sample phases samples 614 61 4 61.4 reference ( 1 wt. (SCM (CO 6 61.

RESUMO Este trabalho considera o aspecto probabilístico da organização do texto a partir da instanciação. Cada instância manifesta de texto se associa à tipologia textual, tanto pelo contexto - como se registra amplamente na literatura - quanto pela configuração linguística mais provável, que é o foco deste trabalho. Descrever como a organização de probabilidade e frequência, assim como os mecanismos pelos quais as frequências emergem, motiva uma configuração linguística e determina como um texto é instanciado torna-se passo necessário para incluir propriedades quantitativas na modelagem. O artigo parte de um corpus de procedimentos, Subcorpus1 - experimentos científicos e receitas; e Subcorpus2 - referente à atividade social de “assar bolo”. Em seguida, identifica o perfil metafuncional dos textos e estabelece regras de associação entre os sistemas para identificar sua chavicidade. Por fim, aplica a metodologia da dinâmica de sistemas. Nos resultados, descrevem-se os mecanismos de subpotencialização, bem como determinam as probabilidades para uma instância ao mesmo tempo em que são constrangidos pela variação do registro. O trabalho aponta a alternativa complementar à análise dos gêneros para se compreender como os textos se organizam e são estruturados. instanciação textual provável frequência emergem tornase torna modelagem procedimentos Subcorpus receitas assar bolo. bolo . bolo” seguida chavicidade fim resultados descrevemse descrevem subpotencialização registro estruturados

ABSTRACT The paper departs from instantiation to explore text in relation to the quantitative properties of language - more specifically how probability plays a part in the matching of an instance and a particular socially-oriented use. Such matching not only links instantiation and stratification, but also helps explaining how different context configurations (patterns of register and genre) are accordingly related to steps in subpotentialization. The fact that language is an inherently probabilistic system may yield a quantitative account of this process if a more complete modelling of language is to be obtained. As part of our exploration, we compiled a corpus of procedures and applied dynamics modelling to tease out quantitative properties of instances associated with context. We described some properties of instantiation - reweighting, association, and dynamics -, which determine the probabilities of an instance configuration, as they also behave following register variation. The paper goes on to show quantitatively how the process of subpotentialization is obtained, leading up to a complementary definition of ‘text’ as a probable unit of instantiation. sociallyoriented socially oriented use stratification patterns genre obtained exploration reweighting association , configuration variation ‘text

Resumo Objetivo: descrever sentimentos expressos por profissionais de saúde no atendimento a vítimas infantojuvenis da violência sexual na perspectiva teórica do Interacionismo Simbólico. Método: pesquisa qualitativa realizada com 30 mulheres profissionais da saúde. Foi aplicado instrumento composto de questões fechadas para dados sociodemográficos e roteiro com perguntas abertas para a entrevista. Os dados foram organizados e analisados no software Nvivo versão 12, de acordo com a proposta de Bardin, sob a ótica do Interacionismo Simbólico na obra de Charles Morris. O projeto foi aprovado por Comitê de Ética em Pesquisa. Resultados: emergiram cinco categorias temáticas que revelaram sentimentos de empatia, medo, indignação, sofrimento e consternação. Tais sentimentos permaneceram na memória das entrevistadas, tornando o atendimento a vítimas infantojuvenis da violência sexual uma experiência tocante, difícil e que marca profundamente a vida do profissional de saúde. Conclusão: há necessidade de adotar estratégias de apoio à saúde mental de profissionais que atuam em serviços que prestam atendimento geral a crianças e adolescentes, considerando que existe a possibilidade de estes atenderem a vítimas infantojuvenis da violência sexual em respeito às políticas públicas preexistentes. Objetivo Método 3 entrevista 12 Bardin Morris Pesquisa Resultados empatia medo indignação consternação entrevistadas tocante Conclusão adolescentes preexistentes 1

Abstract Objective: to describe the feelings expressed by health professionals when caring for child and adolescent victims of sexual violence from the theoretical perspective of Symbolic Interactionism. Method: qualitative research carried out with 30 female health professionals. An instrument was used consisting of closed questions for sociodemographic data and a script with open questions for interviews. The data was organized and analyzed using Nvivo software version 12, according to Bardin’s proposal, from the perspective of Symbolic Interactionism in the work of Charles Morris. The project was approved by the Research Ethics Committee. Results: five thematic categories emerged, revealing feelings of empathy, fear, indignation, suffering, and consternation. These feelings remained in the interviewees’ memories, making caring for child and adolescent victims of sexual violence a moving and difficult experience that deeply marks the life of the health professional. Conclusion: there is a need to adopt strategies to support the mental health of professionals who work in services that provide general care to children and adolescents, considering that there is a possibility that they will provide care to child and adolescent victims of sexual violence in compliance with pre-existing public policies. Objective Method 3 interviews 12 Bardins Bardin s proposal Morris Committee Results emerged empathy fear indignation suffering consternation interviewees memories professional Conclusion adolescents preexisting pre existing policies 1

Resumen Objetivo: describir los sentimientos expresados por los profesionales de la salud en la atención a víctimas infantojuveniles de violencia sexual desde la perspectiva teórica del Interaccionismo Simbólico. Métodos: investigación cualitativa realizada con 30 profesionales de salud. Se utilizó un instrumento compuesto por preguntas cerradas para los datos sociodemográficos y un guión con preguntas abiertas para la entrevista. Los datos fueron organizados y analizados utilizando el software Nvivo versión 12, de acuerdo con la propuesta de Bardin, desde la perspectiva del Interaccionismo Simbólico en la obra de Charles Morris. El proyecto fue aprobado por el Comité de Ética de la Investigación. Resultados: surgieron cinco categorías temáticas que revelaron sentimientos de empatía, miedo, indignación, sufrimiento y consternación. Estos sentimientos permanecieron en la memoria de los entrevistados, convirtiendo la atención a infantojuveniles víctimas de violencia sexual en una experiencia conmovedora y difícil que marca profundamente la vida del profesional de salud. Conclusión: es necesario adoptar estrategias de apoyo a la salud mental de los profesionales que actúan en servicios de atención general a infantojuveniles, considerando que existe la posibilidad de que atiendan a infantojuveniles víctimas de violencia sexual en cumplimiento de políticas públicas preexistentes. Objetivo Métodos 3 entrevista 12 Bardin Morris Investigación Resultados empatía miedo indignación consternación entrevistados Conclusión preexistentes 1

Abstract Introduction Ileostomy formation is performed for multiple purposes related to intestinal pathology, such as obstructive malignant or benign tumors, inflammatory bowel diseases, intestinal ischemia, and, for the most part, as a protective stoma in high-risk anastomosis. The creation of this surgical opening, despite being considered a simple procedure, is undoubtedly followed by complications in certain cases. Materials and Methods We conducted an electronic literature search in the MEDLINE database using the PubMed search engine. A total of 43 articles were included in the present review. Results/Discussion Over the course of the present work, we were able to explore different types of complications that can arise in patients with an ileostomy. High-output stomas were found to be associated with dehydration and electrolyte imbalance. Skin-related morbidity was shown to be present in a great percentage of patients. More severe complications, such as peristomal pyoderma gangrenosum and necrosis, are less frequent and require urgent management. Several risk factors were identified in cases of retraction, obstruction, prolapse, and parastomal herniation. Conclusion Even though ileostomies may present numerous benefits in certain patients, they are also associated with many complications, which should be avoided and quickly managed, because they can severely affect the quality of life of the patients. Surveillance and follow-up by a multidisciplinary team is strongly advisable, bearing in mind that a good performance on the part of the responsible surgeon is also a key factor. pathology tumors diseases ischemia highrisk high anastomosis opening procedure engine 4 review ResultsDiscussion Results Discussion work ileostomy Highoutput High output imbalance Skinrelated Skin necrosis management retraction obstruction prolapse herniation managed followup follow up advisable factor

Abstract The objective of the present study was to investigate the frequency of oral leukoplakia and oral erythroplakia among young patients from three Brazilian reference centers in Oral and Maxillofacial Pathology. A retrospective study was carried out from 2011 to 2021 on 861 patients diagnosed with oral leukoplakia and oral erythroplakia. Demographic and clinicopathological data were evaluated. Fisher’s exact test was used to evaluate the association among sex, age, anatomical location, and histopathological diagnosis. A total of 83 (9.64%) cases involved young patients (aged <40 years). Among these, biopsy records were included in 31 (37.34%) cases, all of which received a clinical diagnosis of oral leukoplakia. Seventeen (54.84%) patients were female, mostly in their fourth decade of life (n = 22/70.97%), and their mean age at diagnosis was 32.61(± 5.21) years. Among informed cases, seven (22.58%) patients were smokers. The lateral border of the tongue (n = 9/29.03%) was the most affected site. In 13 (41.94%) cases, oral leukoplakias showed a homogeneous appearance. The mean size of the lesions was 1.47 cm (0.2–3.0 cm) and the mean time of disease progression was 64.37 (± 65.90) months. The histopathological analysis showed that 11 cases (35.48%) exhibited some degree of epithelial dysplasia. Acanthosis and/or hyperkeratosis were observed in 20 cases (64.52%). No significant associations were observed between sex and anatomical location, age and anatomical location, nor between sex and histological diagnosis (p > 0.05). Oral leukoplakia and oral erythroplakia are uncommon diseases in young patients. In this population, oral leukoplakia shows a slight predilection for women aged between 30 and 39 years. Pathology 201 202 86 evaluated Fishers Fisher s location 8 9.64% 964 9 64 (9.64% 40 <4 years . years) these 3 37.34% 3734 37 34 (37.34% 54.84% 5484 54 84 (54.84% female n 22/70.97%, 227097 22/70.97% , 22 70 97 22/70.97%) 32.61± 3261 32.61 ± 32 61 32.61( 5.21 521 5 21 22.58% 2258 58 (22.58% smokers 9/29.03% 92903 29 03 site 1 41.94% 4194 41 94 (41.94% appearance 147 47 1.4 0.2–3.0 0230 0 2 (0.2–3. 6437 64.3 ( 65.90 6590 65 90 months 35.48% 3548 35 48 (35.48% dysplasia andor or 64.52%. 6452 64.52% 52 (64.52%) p 0.05. 005 0.05 05 0.05) population 9.64 96 6 (9.64 4 < 37.34 373 (37.34 54.84 548 (54.84 22709 22/70.97 7 326 32.6 5.2 22.58 225 (22.58 9/29.03 9290 41.94 419 (41.94 14 1. 0.2–3. 023 (0.2–3 643 64. 65.9 659 35.48 354 (35.48 645 64.52 (64.52% 00 0.0 9.6 (9.6 37.3 (37.3 54.8 (54.8 2270 22/70.9 32. 5. 22.5 (22.5 9/29.0 929 41.9 (41.9 0.2–3 02 (0.2– 65. 35.4 (35.4 64.5 (64.52 0. 9. (9. 37. (37. 54. (54. 227 22/70. 22. (22. 9/29. 92 41. (41. 0.2– (0.2 35. (35. (64.5 (9 (37 (54 22/70 (22 9/29 (41 0.2 (0. (35 (64. (3 (5 22/7 (2 9/2 (4 (0 (64 22/ 9/ (6

Abstract Objective The present study aimed to investigate FOXO3a deregulation in Uterine Smooth Muscle Tumors (USMT) and its potential association with cancer development and prognosis. Methods The authors analyzed gene and protein expression profiles of FOXO3a in 56 uterine Leiomyosarcomas (LMS), 119 leiomyomas (comprising conventional and unusual leiomyomas), and 20 Myometrium (MM) samples. The authors used techniques such as Immunohistochemistry (IHC), FISH/CISH, and qRT-PCR for the present analyses. Additionally, the authors conducted an in-silico analysis to understand the interaction network involving FOXO3a and its correlated genes. Results This investigation revealed distinct expression patterns of the FOXO3a gene and protein, including both normal and phosphorylated forms. Expression levels were notably elevated in LMS, and Unusual Leiomyomas (ULM) compared to conventional Leiomyomas (LM) and Myometrium (MM) samples. This upregulation was significantly associated with metastasis and Overall Survival (OS) in LMS patients. Intriguingly, FOXO3a deregulation did not seem to be influenced by EGF/HER-2 signaling, as there were minimal levels of EGF and VEGF expression detected, and HER-2 and EGFR were negative in the analyzed samples. In the examination of miRNAs, the authors observed upregulation of miR-96-5p and miR-155-5p, which are known negative regulators of FOXO3a, in LMS samples. Conversely, the tumor suppressor miR-let7c-5p was downregulated. Conclusions In summary, the outcomes of the present study suggest that the imbalance in FOXO3a within Uterine Smooth Muscle Tumors might arise from both protein phosphorylation and miRNA activity. FOXO3a could emerge as a promising therapeutic target for individuals with Unusual Leiomyomas and Leiomyosarcomas (ULM and LMS), offering novel directions for treatment strategies. FOXOa FOXO USMT (USMT prognosis 5 , (LMS) 11 comprising leiomyomas, leiomyomas) 2 MM (MM samples IHC, IHC (IHC) FISHCISH FISH CISH FISH/CISH qRTPCR qRT PCR analyses Additionally insilico silico genes forms ULM LM (LM OS (OS patients Intriguingly EGF/HER2 EGFHER2 EGFHER EGF/HER HER EGF/HER- signaling detected HER2 HER- miRNAs miR965p miRp miR 96 5p p miR1555p, miR1555p 155 5p, miR-155-5p Conversely miRlet7c5p miRletcp let7c let c downregulated summary activity LMS) strategies (LMS 1 (IHC 9 15 miRlet letc

ABSTRACT Purpose: This study evaluated the prevalence of complications in the postoperative period of esophagogastric oncological surgeries. Methods: We conducted a retrospective cross-sectional study, adhering to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines. The study size implied 163 patients who underwent surgical treatment for esophageal and gastric cancer and experienced postoperative complications between January 2018 and December 2022. These patients were treated at the Liga Norte Riograndense Contra o Câncer, a high-complexity oncology center and a reference for cancer treatment in Northeast Brazil. Results: The prevalence found was 88.3%. The most prevalent complications were Clavien-Dindo I and II, and infection was the most common. According to our statistics analysis, hypoalbuminemia showed a positive correspondence with the occurrence of postoperative complications (odds ratio = 8.60; 95% confidence interval 1.35–54.64, p = 0.0358). Conclusions: Postoperative complications of gastroesophageal surgeries increase patient morbidity and mortality. Purpose Methods crosssectional cross sectional STROBE (STROBE guidelines 16 201 2022 Câncer highcomplexity high complexity Brazil Results 883 88 3 88.3% ClavienDindo Clavien Dindo II common analysis odds 8.60 860 8 60 95 1355464 1 35 54 64 1.35–54.64 0.0358. 00358 0.0358 . 0 0358 0.0358) Conclusions mortality 20 202 88.3 8.6 86 6 9 135546 5 1.35–54.6 0035 0.035 035 2 88. 8. 13554 1.35–54. 003 0.03 03 1355 1.35–54 00 0.0 135 1.35–5 0. 13 1.35– 1.35 1.3 1.

RESUMO Objetivo: Conhecer as estratégias utilizadas acerca das subnotificações por uso de agrotóxicos no meio rural. Método: Estudo qualitativo realizado em oito unidades básicas de regiões rurais e duas unidades de pronto atendimento de um município do sul do Brasil. A coleta de dados deu-se em 2023, por entrevistas. Participaram 20 profissionais enfermeiros. Os dados foram submetidos à análise de conteúdo. Resultados: Apontaram como estratégias a realização da educação permanente e continuada dos profissionais que realizam a notificação, a busca ativa e a capacitação dos trabalhadores que lidam diretamente com esse tipo de substância, a informatização da notificação por meio do preenchimento das fichas online e a realização de pesquisas acerca da temática. Considerações Finais: Os enfermeiros desempenham um papel importante na notificação de acidentes de trabalho pelo uso de agrotóxicos, melhorando a segurança ocupacional no meio rural. Objetivo rural Método Brasil deuse deu se 2023 entrevistas 2 conteúdo Resultados substância temática Finais 202

ABSTRACT Objective: To learn the strategies used regarding underreporting of pesticide use in rural areas. Methods: A qualitative study was carried out in eight primary healthcare units in rural areas and two emergency care units in a municipality in southern Brazil. Data collection took place in 2023 through interviews. Twenty professional nurses participated. The data was submitted to content analysis. Results: The strategies identified were lifelong and continuing education for the professionals who carry out the notification, active search and training of workers who deal directly with this type of substance, computerizing the notification by filling in the forms online, and carrying out research on the subject. Final considerations: Nurses play an important role in reporting occupational accidents caused by the use of pesticides, improving occupational safety in rural areas. Objective Methods Brazil 202 interviews participated analysis Results substance online subject considerations pesticides 20 2

RESUMEN Objetivo: Conocer las estrategias utilizadas para el subregistro del uso de plaguicidas en áreas rurales. Métodos: Estudio cualitativo realizado en ocho unidades de atención primaria en áreas rurales y dos unidades de atención de emergencia en un municipio del sur de Brasil. La recopilación de datos se realizó en 2023 mediante entrevistas. Participaron 20 profesionales de enfermería. Los datos fueron sometidos a análisis de contenido. Resultados: Las estrategias identificadas fueron la educación continua y permanente de los profesionales que realizan la notificación, la búsqueda activa y la capacitación de los trabajadores que tratan directamente con este tipo de sustancia, la informatización de la notificación mediante el llenado de los formularios en línea y la realización de investigaciones sobre el tema. Consideraciones finales: Los enfermeros desempeñan un papel importante en la notificación de accidentes laborales causados por el uso de plaguicidas, mejorando la seguridad laboral en las zonas rurales. Objetivo Métodos Brasil 202 entrevistas 2 enfermería contenido Resultados sustancia tema finales

Abstract Paper aims The present study addresses this challenge by delving into the influential factors guiding small and medium-sized manufacturing companies towards MES adoption in the context of Industry 4.0. Originality Given the longstanding existence of Manufacturing Execution Systems (MES) for two decades before the development of Industry 4.0 (I4.0) concept, the already complex understanding of MES in the market, particularly among manufacturing companies, has become even more intricate. This complexity is exacerbated when considering MES as a pivotal element for vertical integration within the realm of I4.0. Research method Through in-depth qualitative interviews, six professionals deeply engaged with MES systems, including three from a system development company and three SME experts utilizing the product, were consulted. Main findings The results shed light on how manufacturing SMEs are embracing MES. Drawing upon the technological, organizational, and environmental dimensions, as well as the innovation diffusion process, an integrative model was crafted. This model serves as a lens to scrutinize the intricate process of MES adoption. Implications for theory and practice the article advances the diffusion of innovation theory and the technological-organizational-environment framework, because it brings a consolidated vision of both for the implementation of systems in Industry 4.0. mediumsized medium sized 40 4 0 (MES 4. I4.0 I40 I I4 (I4.0 concept market indepth depth interviews product consulted technological organizational dimensions crafted technologicalorganizationalenvironment environment framework I4. (I4. (I4 (I