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Abstract Introduction: Donor shortage and organ allocation is the main problem in pediatric heart transplant. Mechanical circulatory support is known to increase waiting list survival, but it is not routinely used in pediatric programs in Latin America. Methods: All patients listed for heart transplant and supported by a mechanical circulatory support between January 2012 and March 2016 were included in this retrospective single-center study. The endpoints were mechanical circulatory support time, complications, heart transplant survival and discharge from the hospital. Results: Twenty-nine patients from our waiting list were assessed. Twelve (45%) patients were initially supported by extracorporeal membrane oxygenation (ECMO) and a centrifugal pump was implanted in 17 (55%) patients. Five patients initially supported by ECMO were bridged to another device. One was bridged to a centrifugal pump and four were bridged to Berlin Heart Excor®. Among the 29 supported patients, 18 (62%) managed to have a heart transplant. Thirty-day survival period after heart transplant was 56% (10 patients). Median support duration was 12 days (interquartile range [IQR] 4 - 26 days) per run and the waiting time for heart transplant was 9.5 days (IQR 2.5-25 days). Acute kidney injury was identified as a mortality predictor (OR=22.6 [CI=1.04-494.6]; P=0.04). Conclusion: Mechanical circulatory support was able to bridge most INTERMACS 1 and 2 pediatric patients to transplant with an acceptable complication rate. Acute renal failure increased mortality after mechanical circulatory support in our experience.

https://doi.org/10.21470/1678-9741-2018-0081 696 downloads

Enfoque de una salud en las acciones para enfrentar la resistencia a los antimicrobianos desde una óptica latinoamericana
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Ramon Pardo, Pilar

; Sati, Hatim

; Galas, Marcelo

Revista Peruana de Medicina Experimental y Salud Pública

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mar 2018, Volume 35 N. 1 Pages 103 - 109

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

ABSTRACT Antimicrobial resistance is a complex epidemiology problem worldwide which calls for a wide and integrated approach such as "One Health." Resistant organisms are present in humans, animals, food, and the environment, and the main impeller of this resistance is the use of antimicrobial agents. The occurrence and propagation of antimicrobial resistance continue incessantly in the world, leaving devastating economic and health consequences behind. In 2015, the WHO, in collaboration with key partners such as the FAO and the OIE, developed the World Action Plan in Antimicrobial Resistance, under the perspective of "One Health." This Plan was endorsed by several countries and seeks collaboration for the prevention and control of antimicrobial resistance. This article aims at explaining the scope of the "One Health" approach within the context of antimicrobial resistance, the reason behind its adoption and what is expected from it. One of the main conclusions is the significant lack of knowledge on the selection and propagation of resistant organisms in the environment, with an emphasis on the threats and risks that this represents to human and animal health. Efforts need to be strengthened in order to better define the risks, design interventions, and measure its impact on antimicrobial resistance.

RESUMEN La resistencia a los antimicrobianos es un problema global de epidemiología compleja, adecuado para un enfoque amplio e integrado de «Una Salud». Existen organismos resistentes en humanos, animales, alimentos y el medio ambiente, y el principal impulsor de esta resistencia es el uso de antimicrobianos. La aparición y propagación de la resistencia a los antimicrobianos continúa sin cesar en todo el mundo, dejando devastadores resultados de salud y económicos a su paso. En el 2015, la OMS, en colaboración con socios clave como la FAO y la OIE, desarrolló el Plan de Acción Mundial en Resistencia a los Antimicrobianos, bajo la perspectiva de «Una Salud». Este Plan fue endosado por los países y busca la colaboración para la prevención y control de la resistencia a los antimicrobianos. En este artículo, se pretende explicar el alcance del enfoque «Una Salud» en el contexto de la resistencia a los antimicrobianos, por qué se ha adoptado y qué se espera lograr con ello. Una de las conclusiones principales es la gran falta de conocimiento sobre la selección y propagación de organismos resistentes en el medio ambiente, con énfasis en las amenazas y riesgos que esto representa para la salud humana y animal. Se han de intensificar los esfuerzos para mejor definir los riesgos, diseñar las intervenciones y medir su impacto en la resistencia a los antimicrobianos.

https://doi.org/10.17843/rpmesp.2018.351.3605 66 downloads

Enfoque de Una Salud en las acciones para enfrentar la resistencia a los antimicrobianos desde una óptica latinoamericana
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Ramon Pardo, Pilar

; Sati, Hatim

; Galas, Marcelo

Revista Peruana de Medicina Experimental y Salud Publica

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jan 2018, Volume 35 N. 1 Pages 103 - 109

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Antimicrobial resistance is a complex epidemiology problem worldwide which calls for a wide and integrated approach such as "One Health." Resistant organisms are present in humans, animals, food, and the environment, and the main impeller of this resistance is the use of antimicrobial agents. The occurrence and propagation of antimicrobial resistance continue incessantly in the world, leaving devastating economic and health consequences behind. In 2015, the WHO, in collaboration with key partners such as the FAO and the OIE, developed the World Action Plan in Antimicrobial Resistance, under the perspective of "One Health." This Plan was endorsed by several countries and seeks collaboration for the prevention and control of antimicrobial resistance. This article aims at explaining the scope of the "One Health" approach within the context of antimicrobial resistance, the reason behind its adoption and what is expected from it. One of the main conclusions is the significant lack of knowledge on the selection and propagation of resistant organisms in the environment, with an emphasis on the threats and risks that this represents to human and animal health. Efforts need to be strengthened in order to better define the risks, design interventions, and measure its impact on antimicrobial resistance.

La resistencia a los antimicrobianos es un problema global de epidemiología compleja, adecuado para un enfoque amplio e integrado de «Una Salud». Existen organismos resistentes en humanos, animales, alimentos y el medio ambiente, y el principal impulsor de esta resistencia es el uso de antimicrobianos. La aparición y propagación de la resistencia a los antimicrobianos continúa sin cesar en todo el mundo, dejando devastadores resultados de salud y económicos a su paso. En el 2015, la OMS, en colaboración con socios clave como la FAO y la OIE, desarrolló el Plan de Acción Mundial en Resistencia a los Antimicrobianos, bajo la perspectiva de «Una Salud». Este Plan fue endosado por los países y busca la colaboración para la prevención y control de la resistencia a los antimicrobianos. En este artículo, se pretende explicar el alcance del enfoque «Una Salud» en el contexto de la resistencia a los antimicrobianos, por qué se ha adoptado y qué se espera lograr con ello. Una de las conclusiones principales es la gran falta de conocimiento sobre la selección y propagación de organismos resistentes en el medio ambiente, con énfasis en las amenazas y riesgos que esto representa para la salud humana y animal. Se han de intensificar los esfuerzos para mejor definir los riesgos, diseñar las intervenciones y medir su impacto en la resistencia a los antimicrobianos.

https://doi.org/10.17843/rpmesp.2018.351.3605

Brazilian Consensus on perioperative hemodynamic therapy goal guided in patients undergoing noncardiac surgery: fluid management strategy - produced by the São Paulo State Society of Anesthesiology (Sociedade de Anestesiologia do Estado de São Paulo - SAESP)
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Silva, Enis Donizetti

; Perrino, Albert Carl

; Teruya, Alexandre

; Sweitzer, Bobbie Jean

; Gatto, Chiara Scaglioni Tessmer

; Simões, Claudia Marquez

; Rezende, Ederlon Alves Carvalho

; Galas, Filomena Regina Barbosa Gomes

; Lobo, Francisco Ricardo

; Silva Junior, João Manoel da

; Taniguchi, Leandro Ultino

; Azevedo, Luciano Cesar Pontes de

; Hajjar, Ludhmila Abrahão

; Mondadori, Luiz Antônio

; Abreu, Marcelo Gama de

; Perez, Marcelo Vaz

; Dib, Regina El

; Nascimento Junior, Paulo do

; Rodrigues, Roseny dos Reis

; Lobo, Suzana Margareth

; Nunes, Rogean Rodrigues

; Assunção, Murillo Santucci Cesar de

Revista Brasileira de Anestesiologia

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dec 2016, Volume 66 N. 6 Pages 557 - 571

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1016/j.bjane.2016.09.007 8160 downloads

Post-cardiotomy ECMO in pediatric and congenital heart surgery: impact of team training and equipment in the results
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Miana, Leonardo Augusto

; Canêo, Luiz Fernando

; Tanamati, Carla

; Penha, Juliano Gomes

; Guimarães, Vanessa Alves

; Miura, Nana

; Galas, Filomena Regina Barbosa Gomes

; Jatene, Marcelo Biscegli

Brazilian Journal of Cardiovascular Surgery

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aug 2015, Volume 30 N. 4 Pages 409 - 416

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Falência ventricular pós-cardiotomia necessitando de suporte circulatório mecânico ocorre em cerca de 0,5% dos casos. Em nosso meio, o uso de ECMO tem aumentado nos últimos anos. Objetivo: Avaliar o impacto do investimento na formação profissional e melhoria dos equipamentos na taxa de desmame de ECMO e na sobrevida. Métodos: Estudo retrospectivo. Cinquenta e seis pacientes cardíacos pediátricos e/ou portadores de cardiopatias congênitas foram submetidos ao implante de ECMO pós-cardiotomia em nossa instituição entre novembro de 1999 e julho de 2014. Nós dividimos este período em duas fases: fase I, 36 casos (antes da estruturação do programa de ECMO) e fase II, 20 casos (após a instalação do programa ECMO com investimento em formação e equipamento). Foram considerados como desfechos primários: o desmame de ECMO e sobrevida até a alta hospitalar. Os resultados em ambas as fases foram comparados pelo teste Chi-quadrado. Para identificar o impacto das diferentes variáveis, foi usada análise de regressão logística binária. Resultados: Na fase I, 9 pacientes (25%) foram desmamados da ECMO, mas apenas 2 (5,5%) tiveram alta. Na fase II, ECMO foi usado em 20 pacientes, o desmame foi possível em 17 deles (85%), com 9 (45%) altas hospitalares. Quando analisamos o impacto das diversas variáveis sobre a sobrevida e desmame de ECMO, observa-se que a fase II foi um preditor independente de melhores resultados (P<0,001) e a necessidade de drenagem das cavidades esquerdas foi associada com pior sobrevida (P=0,045). Conclusão: O investimento na formação profissional e aperfeiçoamento de equipamentos melhorou significativamente os resultados de ECMO em nossa instituição.

Abstract Introduction: Post-cardiotomy myocardial dysfunction requiring mechanical circulatory support occurs in about 0.5% of cases. In our environment, the use of extracorporeal membrane oxygenation has been increasing in recent years. Objective: To evaluate the impact of investment in professional training and improvement of equipment in the rate of weaning from extracorporeal membrane oxygenation and survival. Methods: A retrospective study. Fifty-six pediatric and/or congenital heart patients underwent post-cardiotomy extracorporeal membrane oxygenation at our institution between November 1999 and July 2014. We divided this period into two phases: phase I, 36 cases (before the structuring of the extracorporeal membrane oxygenation program) and phase II, 20 cases (after the extracorporeal membrane oxygenation program implementation) with investment in training and equipment). Were considered as primary outcomes: extracorporeal membrane oxygenation weaning and survival to hospital discharge. The results in both phases were compared using Chi-square test. To identify the impact of the different variables we used binary logistic regression analysis. Results: Groups were comparable. In phase I, 9 patients (25%) were weaned from extracorporeal membrane oxygenation, but only 2 (5.5%) were discharged. In phase II, extracorporeal membrane oxygenation was used in 20 patients, weaning was possible in 17 (85%), with 9 (45%) hospital discharges (P<0.01). When the impact of several variables on discharge and weaning of extracorporeal membrane oxygenation was analyzed, we observe that phase II was an independent predictor of better results (P<0.001) and need for left cavities drainage was associated with worse survival (P=0.045). Conclusion: The investment in professional training and improvement of equipment significantly increased extracorporeal membrane oxygenation results.

https://doi.org/10.5935/1678-9741.20150053 2681 downloads

Use of Short-term Circulatory Support as a Bridge in Pediatric Heart Transplantation
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Canêo, Luiz Fernando

; Miana, Leonardo Augusto

; Tanamati, Carla

; Penha, Juliano Gomes

; Shimoda, Monica Satsuki

; Azeka, Estela

; Miura, Nana

; Galas, Filomena Regina Barbosa Gomes

; Guimarães, Vanessa Alves

; Jatene, Marcelo Biscegli

Arquivos Brasileiros de Cardiologia

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jan 2015, Volume 104 N. 1 Pages 78 - 84

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Introdução:O transplante cardíaco é o tratamento de escolha na insuficiência cardíaca terminal, porém a escassez de doadores limita o seu emprego, especialmente na população pediátrica. O implante de dispositivos de assistência circulatória mecânica (ACM) pode aumentar o tempo de espera e contribuir na redução da mortalidade.Objetivo:Estudar a evolução dos pacientes pediátricos com diagnóstico de miocardiopatia, com indicação de transplante e que evoluíram em Intermacs1 ou 2, comparando a utilização ou não de algum tipo de ACM de curta duração.Método:No período de janeiro de 2011 a dezembro de 2013, 40 pacientes com idade média de 4,5 anos foram admitidos com diagnóstico de miocardiopatia dilatada. Desses pacientes, 20 evoluíram em Intermacs 1 ou 2. Um faleceu em menos de 24 horas e 19 foram listados para transplante. Os pacientes foram divididos em dois grupos: A, pacientes manejados clinicamente em espera para o transplante; B, pacientes que utilizaram algum tipo de ACM de curta duração durante o tempo de espera em lista.Resultados:No grupo A (n=10), oito pacientes evoluíram para óbito aguardando o transplante e dois pacientes (20%) foram transplantados, sendo que nenhum recebeu alta hospitalar. No grupo B (n = 9), seis pacientes (66,7%; p = 0,04) foram transplantados e três receberam alta hospitalar (p = 0,049). As principais complicações foram insuficiência renal e sepse, no grupo A, e complicações neurológicas no grupo B.Conclusão:O emprego de ACM de curta duração aumentou a sobrevida dos pacientes priorizados e em fila de espera de transplante cardíaco pediátrico.

Background:Heart transplantation is considered the gold standard therapy for the advanced heart failure, but donor shortage, especially in pediatric patients, is the main limitation for this procedure, so most sick patients die while waiting for the procedure.Objective:To evaluate the use of short-term circulatory support as a bridge to transplantation in end-stage cardiomyopathy.Methods:Retrospective clinical study. Between January 2011 and December 2013, 40 patients with cardiomyopathy were admitted in our Pediatric Intensive Care Unit, with a mean age of 4.5 years. Twenty patients evolved during hospitalization with clinical deterioration and were classified as Intermacs 1 and 2. One patient died within 24 hours and 19 could be stabilized and were listed. They were divided into 2 groups: A, clinical support alone and B, implantation of short-term circulatory support as bridge to transplantation additionally to clinical therapy.Results:We used short-term mechanical circulatory support as a bridge to transplantation in 9. In group A (n=10), eight died waiting and 2 patients (20%) were transplanted, but none was discharged. In group B (n=9), 6 patients (66.7%) were transplanted and three were discharged.The mean support time was 21,8 days (6 to 984h). The mean transplant waiting list time was 33,8 days. Renal failure and sepsis were the main complication and causeof death in group A while neurologic complications were more prevalent en group B.Conclusion:Mechanical circulatory support increases survival on the pediatric heart transplantation waiting list in patients classified as Intermacs 1 and 2.

https://doi.org/10.5935/abc.20140165 2153 downloads

Situación epidemiológica de coqueluche y estrategias para su control: Argentina, 2002-2011
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Romanin, Viviana

; Agustinho, Vanina

; Califano, Gloria

; Sagradini, Sandra

; Aquino, Analía

; Juárez, María del Valle

; Antman, Julián

; Giovacchini, Carlos

; Galas, Marcelo

; Lara, Claudia

; Hozbor, Daniela

; Gentile, Ángela

; Vizzotti, Carla

Archivos argentinos de pediatría

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oct 2014, Volume 112 N. 5 Pages 413 - 420

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Introduction. Pertussis is a challenge for public health. Objectives: To describe pertussis-related morbidity and mortality and immunization coverage for the 2002-2011 period, profile of cases for 2011, and control strategies implemented by the Ministry of Health (MoH) of Argentina. Methods. Descriptive, epidemiological surveillance study. Morbidity data were obtained from the National Health Surveillance System, while mortality data were obtained from the MoH's Health Statistics and Information Department and official jurisdictional reports. Administrative immunization coverage was used based on the data provided by the MoH's jurisdictions. The Epi Info software, version 7.1.2, was used for analysis. Results. The number of reported cases of pertussis increased between 2002 and 2011, reaching its peak in 2011: an incidence of 16 x 100 000 inhabitants, and 76 deaths. Most deaths occurred in infants younger than 1 year old. Immunization coverage achieved at a national level with the third dose and the dose administered at the time of starting primary education was >90%, while the coverage achieved with the first booster dose was 80%-90%. In 2011, 2821 confirmed cases were reported (incidence of 7 x 100 000 inhabitants): 84% in infants <1 year old; 76 deaths: 97% in infants <1 year old (60.5% in infants <2 months old). Among the strategies that were deployed, a total of 906 clinical nodes and 405 laboratory nodes were consolidated; the use of the polymerase chain reaction as a diagnostic method and the differential classification of cases were implemented, and additional vaccine doses were administered. Conclusions . The number of pertussis cases increased between2002 and 2011; the highest morbidity and mortality occurred ininfants younger than 1 year old; immunization coverage reached 80%-90%. . The highest number of pertussis-related deaths was recorded in 2011. . The MoH strengthened the epidemiological surveillance and set guidelines for control measures.

Introducción. Coqueluche constituye un problema de salud pública. Objetivos: Describir la morbimortalidad y coberturas de vacunación entre 2002 y 2011, el perfil de los casos de 2011 y las estrategias de control implementadas por el Ministerio de Salud (MSN). Métodos. Estudio descriptivo de vigilancia epidemiológica. Los datos de morbilidad se tomaron del Sistema Nacional de Vigilancia, y los de mortalidad, de la Dirección de Estadística e Información en Salud del MSN y de los informes oficiales de las jurisdicciones. Se utilizó la cobertura administrativa de vacunación a partir de datos provistos por las jurisdicciones al MSN. Se analizó con Epiinfo 7.1.2. Resultados. Entre 2002 y 2011, la notificación de casos de coqueluche y de fallecimientos se incrementó y alcanzó los mayores valores en 2011: tasa de 16 x 100 000 habitantes y 76 fallecidos. Las muertes ocurrieron mayoritariamente en <1 año y las coberturas nacionales de vacunación para 3ra dosis e ingreso escolar fueron >90% y para el primer refuerzo, 80-90%. En 2011, se notificaron 2821 casos confirmados (incidencia 7 x 100 000 hab.): 84% <1 año; 76 fallecidos: 97% <1 año (60,5% <2 meses). Entre las estrategias implementadas, se consolidaron 906 nodos clínicos y 405 de laboratorio; se implementaron la reacción en cadena de la polimerasa como método diagnóstico y la clasificación diferencial de los casos, y se incorporaron dosis adicionales de vacunación. Conclusiones . Entre 2002 y 2011, aumentaron los casos de coqueluche; la mayor morbimortalidad fue en <1 año, con coberturas de vacunación de 80 y 90%. . El mayor número de fallecidos por coqueluche fue en el año 2011. . El MSN fortaleció la vigilancia epidemiológica y orientó las medidas de control.

https://doi.org/10.5546/aap.2014.413 950 downloads Cited 3 times in SciELO

10.

Recomendações brasileiras de ventilação mecânica 2013. Parte 2
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Barbas, Carmen Sílvia Valente

; Ísola, Alexandre Marini

; Farias, Augusto Manoel de Carvalho

; Cavalcanti, Alexandre Biasi

; Gama, Ana Maria Casati

; Duarte, Antonio Carlos Magalhães

; Vianna, Arthur

; Serpa Neto, Ary

; Bravim, Bruno de Arruda

; Pinheiro, Bruno do Valle

; Mazza, Bruno Franco

; Carvalho, Carlos Roberto Ribeiro de

; Toufen Júnior, Carlos

; David, Cid Marcos Nascimento

; Taniguchi, Corine

; Mazza, Débora Dutra da Silveira

; Dragosavac, Desanka

; Toledo, Diogo Oliveira

; Costa, Eduardo Leite

; Caser, Eliana Bernadete

; Silva, Eliezer

; Amorim, Fabio Ferreira

; Saddy, Felipe

; Galas, Filomena Regina Barbosa Gomes

; Silva, Gisele Sampaio

; Matos, Gustavo Faissol Janot de

; Emmerich, João Claudio

; Valiatti, Jorge Luis dos Santos

; Teles, José Mario Meira

; Victorino, Josué Almeida

; Ferreira, Juliana Carvalho

; Prodomo, Luciana Passuello do Vale

; Hajjar, Ludhmila Abrahão

; Martins, Luiz Claudio

; Malbouisson, Luis Marcelo Sá

; Vargas, Mara Ambrosina de Oliveira

; Reis, Marco Antonio Soares

; Amato, Marcelo Brito Passos

; Holanda, Marcelo Alcântara

; Park, Marcelo

; Jacomelli, Marcia

; Tavares, Marcos

; Damasceno, Marta Cristina Paulette

; Assunção, Murillo Santucci César

; Damasceno, Moyzes Pinto Coelho Duarte

; Youssef, Nazah Cherif Mohamed

; Teixeira, Paulo José Zimmermann

; Caruso, Pedro

; Duarte, Péricles Almeida Delfino

; Messeder, Octavio

; Eid, Raquel Caserta

; Rodrigues, Ricardo Goulart

; Jesus, Rodrigo Francisco de

; Kairalla, Ronaldo Adib

; Justino, Sandra

; Nemer, Sergio Nogueira

; Romero, Simone Barbosa

; Amado, Verônica Moreira

Revista Brasileira de Terapia Intensiva

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sep 2014, Volume 26 N. 3 Pages 215 - 239

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O suporte ventilatório artificial invasivo e não invasivo ao paciente grave tem evoluído e inúmeras evidências têm surgido, podendo ter impacto na melhora da sobrevida e da qualidade do atendimento oferecido nas unidades de terapia intensiva no Brasil. Isto posto, a Associação de Medicina Intensiva Brasileira (AMIB) e a Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) - representadas por seu Comitê de Ventilação Mecânica e sua Comissão de Terapia Intensiva, respectivamente, decidiram revisar a literatura e preparar recomendações sobre ventilação mecânica, objetivando oferecer aos associados um documento orientador das melhores práticas da ventilação mecânica na beira do leito, com base nas evidências existentes, sobre os 29 subtemas selecionados como mais relevantes no assunto. O projeto envolveu etapas que visaram distribuir os subtemas relevantes ao assunto entre experts indicados por ambas as sociedades, que tivessem publicações recentes no assunto e/ou atividades relevantes em ensino e pesquisa no Brasil, na área de ventilação mecânica. Esses profissionais, divididos por subtemas em duplas, responsabilizaram-se por fazer uma extensa revisão da literatura mundial. Reuniram-se todos no Fórum de Ventilação Mecânica, na sede da AMIB, na cidade de São Paulo (SP), em 3 e 4 de agosto de 2013, para finalização conjunta do texto de cada subtema e apresentação, apreciação, discussão e aprovação em plenária pelos 58 participantes, permitindo a elaboração de um documento final.

https://doi.org/10.5935/0103-507X.20140034 89689 downloads

11.

Estudio de seroprevalencia de coqueluche en adultos jóvenes, mujeres en puerperio inmediato y sangre del cordón umbilical
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Fallo, Aurelia

; Manonelles, Gabriela

; Hozbor, Daniela

; Lara, Claudia

; Huespe, Miguel

; Mazzeo, Silvina

; Canle, Oscar

; Galas, Marcelo

; López, Eduardo

Archivos argentinos de pediatría

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aug 2014, Volume 112 N. 4 Pages 315 - 322

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Pertussis is a vaccine-preventable disease that affects people of all ages. Young adults who have lost their immunity to pertussis are the major source of infection in infants. Given the steady increase of pertussis cases, new prevention strategies are required. Objective. To assess pertussis seroprevalence in adult blood donors, post-partum women, and umbilical cords. Metod. Measurement of total titers of anti-Bordetella spp. (Bordetella) antibodies using an enzyme-linked immunosorbent assay. Serum samples from 103 donors, 101 post-partum women and 100 umbilical cords were analyzed. Titers <80 were considered of low impact against the disease. The assessment included transplacental transfer of antibodies and the umbilical cord/maternal ratio of antibody titers. Results. Donors mean age was: 28 ± 6 years old. Mediananti-Bordetella titers: 320; interquartile range (IQR):160-320; 10% had titers <80. Post-partum women mean age was: 26 ± 6 years old. Median anti-Bordetella titers:160 (IQR:80-320), with titers significantly lower than in female donors (p= 0.00002). Titers <80 were found in 30% of post-partum women. Median anti-Bordetella titers in umbilical cords: 160 (IQR: 80-160). Titers <80 were more frequently found in umbilical cords than in mothers (44% versus 30%, p= 0.04). Transplacental transfer was 0.83. Umbilical cord titers were equal to maternal titers in 54% of cases, lower in 37%, and higher only in 8%. Conclusion. Titers of anti-Bordetella antibodies in post-partum women were significantly lower than in female blood donors. Titers <80 were found in 30% of post-partum women and 44% of umbilical cords. These data may account for the high rates of pertussis in young infants who have not yet completed their vaccination schedule.

La coqueluche es una enfermedad inmunopreve-nible que afecta a todas las edades. Los adultos jóvenes que han perdido su inmunidad contra pertussis son una importante fuente de infección para los lactantes. Ante el aumento sostenido de casos de coqueluche, se plantean nuevas estrategias de prevención. Objetivo. Evaluar la seroprevalencia de coqueluche en donantes de sangre adultos, puérperas y cordones. Métodos. Determinación de títulos de anticuerpos totales anti-Bordetella spp (Bordetella) mediante el ensayo por inmunoabsorción ligado a enzimas. Se evaluaron sueros de 103 donantes, 101 puérperas y 100 cordones. Los títulos < 80 fueron considerados de bajo impacto contra la enfermedad. El pasaje transplacentario de anticuerpos fue evaluado como la relación en los títulos de anticuerpos en cordones/madres. Resultados. Media de edad de los donantes: 28 ± 6 años. Mediana títulos anti-Bordetella: 320; rango intercuartil: 160-320 (RIC); 10% presentaron títulos < 80. Media de edad de las puérperas: 26 ± 6 años. Mediana títulos anti-Bordetella: 160 (RIC: 80320), títulos significativamente menores que las mujeres donantes (p= 0,00002). El 30% de las puérperas presentaron títulos < 80. Mediana anti-Bordetella cordones: 160 (RIC: 80160). Los cordones presentaron títulos < 80 más frecuentemente que sus madres (44% vs. 30%, p= 0,04). El pasaje transplacentario fue 0,83. El título en los cordones fue igual a sus madres en el 54%, menor en el 37% y mayor solo en el 8%. Conclusiones. Los títulos de anticuerpos anti-Bordetella en las puérperas fueron significativamente menores que en las donantes. Las madres y los cordones presentaron títulos < 80 en el 30% y el 44%, respectivamente. Estos datos podrían explicar las altas tasas de ataque en lactantes pequeños que no han completado su esquema de vacunación.

https://doi.org/10.5546/aap.2014.315 346 downloads Cited 2 times in SciELO

12.

Recomendações brasileiras de ventilação mecânica 2013. Parte I
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Barbas, Carmen Sílvia Valente

; Ísola, Alexandre Marini

; Farias, Augusto Manoel de Carvalho

; Cavalcanti, Alexandre Biasi

; Gama, Ana Maria Casati

; Duarte, Antonio Carlos Magalhães

; Vianna, Arthur

; Serpa Neto, Ary

; Bravim, Bruno de Arruda

; Pinheiro, Bruno do Valle

; Mazza, Bruno Franco

; Carvalho, Carlos Roberto Ribeiro de

; Toufen Júnior, Carlos

; David, Cid Marcos Nascimento

; Taniguchi, Corine

; Mazza, Débora Dutra da Silveira

; Dragosavac, Desanka

; Toledo, Diogo Oliveira

; Costa, Eduardo Leite

; Caser, Eliana Bernardete

; Silva, Eliezer

; Amorim, Fabio Ferreira

; Saddy, Felipe

; Galas, Filomena Regina Barbosa Gomes

; Silva, Gisele Sampaio

; Matos, Gustavo Faissol Janot de

; Emmerich, João Claudio

; Valiatti, Jorge Luis dos Santos

; Teles, José Mario Meira

; Victorino, Josué Almeida

; Ferreira, Juliana Carvalho

; Prodomo, Luciana Passuello do Vale

; Hajjar, Ludhmila Abrahão

; Martins, Luiz Cláudio

; Malbouisson, Luiz Marcelo Sá

; Vargas, Mara Ambrosina de Oliveira

; Reis, Marco Antonio Soares

; Amato, Marcelo Brito Passos

; Holanda, Marcelo Alcântara

; Park, Marcelo

; Jacomelli, Marcia

; Tavares, Marcos

; Damasceno, Marta Cristina Paulette

; Assunção, Murillo Santucci César

; Damasceno, Moyzes Pinto Coelho Duarte

; Youssef, Nazah Cherif Mohamad

; Teixeira, Paulo José Zimmermann

; Caruso, Pedro

; Duarte, Péricles Almeida Delfino

; Messeder, Octavio

; Eid, Raquel Caserta

; Rodrigues, Ricardo Goulart

; Jesus, Rodrigo Francisco de

; Kairalla, Ronaldo Adib

; Justino, Sandra

; Nemer, Sérgio Nogueira

; Romero, Simone Barbosa

; Amado, Verônica Moreira

Revista Brasileira de Terapia Intensiva

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apr 2014, Volume 26 N. 2 Pages 89 - 121

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O suporte ventilatório artificial invasivo e não invasivo ao paciente crítico tem evoluído e inúmeras evidências têm surgido, podendo ter impacto na melhora da sobrevida e da qualidade do atendimento oferecido nas unidades de terapia intensiva no Brasil. Isto posto, a Associação de Medicina Intensiva Brasileira (AMIB) e a Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) - representadas pelo seus Comitê de Ventilação Mecânica e Comissão de Terapia Intensiva, respectivamente, decidiram revisar a literatura e preparar recomendações sobre ventilação mecânica objetivando oferecer aos associados um documento orientador das melhores práticas da ventilação mecânica na beira do leito, baseado nas evidencias existentes, sobre os 29 subtemas selecionados como mais relevantes no assunto. O projeto envolveu etapas visando distribuir os subtemas relevantes ao assunto entre experts indicados por ambas as sociedades que tivessem publicações recentes no assunto e/ou atividades relevantes em ensino e pesquisa no Brasil na área de ventilação mecânica. Esses profissionais, divididos por subtemas em duplas, responsabilizaram-se por fazer revisão extensa da literatura mundial sobre cada subtema. Reuniram-se todos no Forum de Ventilação Mecânica na sede da AMIB em São Paulo, em 03 e 04 de agosto de 2013 para finalização conjunta do texto de cada subtema e apresentação, apreciação, discussão e aprovação em plenária pelos 58 participantes, permitindo a elaboração de um documento final.

Perspectives on invasive and noninvasive ventilatory support for critically ill patients are evolving, as much evidence indicates that ventilation may have positive effects on patient survival and the quality of the care provided in intensive care units in Brazil. For those reasons, the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB) and the Brazilian Thoracic Society (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT), represented by the Mechanical Ventilation Committee and the Commission of Intensive Therapy, respectively, decided to review the literature and draft recommendations for mechanical ventilation with the goal of creating a document for bedside guidance as to the best practices on mechanical ventilation available to their members. The document was based on the available evidence regarding 29 subtopics selected as the most relevant for the subject of interest. The project was developed in several stages, during which the selected topics were distributed among experts recommended by both societies with recent publications on the subject of interest and/or significant teaching and research activity in the field of mechanical ventilation in Brazil. The experts were divided into pairs that were charged with performing a thorough review of the international literature on each topic. All the experts met at the Forum on Mechanical Ventilation, which was held at the headquarters of AMIB in São Paulo on August 3 and 4, 2013, to collaboratively draft the final text corresponding to each sub-topic, which was presented to, appraised, discussed and approved in a plenary session that included all 58 participants and aimed to create the final document.

https://doi.org/10.5935/0103-507X.20140017 321115 downloads

13.

Clinical recommendations for postoperative care after heart transplantation in children: 21 years of a single-center experience
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Azeka, Estela

; Jatene, Marcelo Biscegli

; Tanaka, Ana Cristina

; Galas, Filomena Regina

; Hajjar, Ludhmilla Abrahao

; Miura, Nana

; Auler Junior, Jose Otavio Costa

Clinics

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jan 2014, Volume 69 Suppl. 1 Pages 47 - 50

Abstract: En | Text: En | PDF: En

Heart transplantation is an option for children with complex congenital heart disease and cardiomyopathies. A patient's quality of life and long-term survival depend on successful management of the surgical complications and adverse side effects of immunosuppression. The purpose of this review was to summarize the practical management of postoperative care in this patient population and to make recommendations for the future.

https://doi.org/10.6061/clinics/2014(Sup01)09 3349 downloads Cited 1 time in SciELO

14.

Terapia de reposição volêmica durante artroplastia de quadril usando hidroxietilamido (130/0,4) comparado com Ringer lactato diminui transfusão de sangue alogênico e infecção pós-operatória
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Hamaji, Adilson

; Hajjar, Ludhmila

; Caiero, Marcelo

; Almeida, Juliano

; Nakamura, Rosana Ely

; Osawa, Eduardo A

; Fukushima, Julia

; Galas, Filomena R

; Auler Junior, Jose Otavio Costa

Revista Brasileira de Anestesiologia

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feb 2013, Volume 63 N. 1 Pages 36 - 44

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

JUSTIFICATIVA E OBJETIVOS: O hidroxietilamido 130/0,4 (HES 130/0,4) é considerado um expansor plasmático efetivo quando comparado com cristaloides. Há controvérsia sobre sua superioridade em relação à otimização hemodinâmica e sobre possíveis efeitos prejudiciais na coagulação. O objetivo deste estudo foi comparar os efeitos do HES 130/0,4 com os da solução de Ringer lactato durante artroplastia de quadril em pacientes adultos sob raquianestesia e levou em consideração sangramento intraoperatório, parâmetros hemodinâmicos, coagulograma, necessidade de transfusão e desfechos clínicos. MÉTODOS: Neste estudo randômico e controlado, 48 pacientes agendados para artroplastia de quadril com raquianestesia foram alocados em dois grupos: 24 receberam uma pré-carga de HES 130/0,4 (15 mL.kg-1) e 24 receberam uma pré-carga de solução de Ringer lactato (30 mL. kg-1) antes da cirurgia. Mensurações hemodinâmicas, concentração de hemoglobina, parâmetros bioquímicos e testes de coagulação foram avaliados em três períodos durante o procedimento cirúrgico. Os pacientes receberam acompanhamento médico durante a internação e até 30 dias no período pós-operatório. O principal fator foi a necessidade de transfusão de hemácias entre os grupos durante a internação. Os fatores secundários foram parâmetros hemodinâmicos, tempo de internação, mortalidade e ocorrência de complicações clínicas. no período pós-operatório. O principal fator foi a necessidade de transfusão de hemácias entre os grupos durante a internação. Os fatores secundários foram parâmetros hemodinâmicos, tempo de internação, mortalidade e ocorrência de complicações clínicas. RESULTADOS: A transfusão de hemácias foi necessária em 17% dos pacientes do grupo HES e em 46% dos pacientes do grupo Ringer lactato (p = 0,029). Infecções pós-operatórias foram observadas com mais frequência no grupo de Ringer lactato (17%) em comparação com o grupo HES (0), p = 0,037. Não houve diferenças significativas entre os grupos em relação à mortalidade, ao tempo de internação e às complicações clínicas, exceto infecção. CONCLUSÕES: Durante a artroplastia de quadril, os pacientes tratados com hemodiluição hipervolêmica normal com hidroxietilamido 130/0,4 precisaram de menos transfusão e apresentaram índice menor de infecção em comparação com os pacientes que receberam Ringer lactato.

BACKGROUND AND OBJECTIVES: Hydroxyethyl starch (HES) 130/0.4 is considered an effective plasma expander when compared to crystalloids. There is controversy around its superiority regarding hemodynamic optimization and about possible detrimental effects on coagulation. The aim of this study was to compare the effects of HES 130/0.4 to lactated Ringer solution during hip arthroplasty in adult patients under spinal anesthesia regarding intraoperative bleeding, hemodynamic parameters, coagulation profile, transfusion requirements and clinical outcomes. METHODS: In this randomized, controlled trial, 48 patients scheduled for hip arthroplasty with spinal anesthesia were randomized into two groups: 24 patients were allocated to receive a preload of 15 mL.kg-1 of HES 130/0.4 and 24 patients received a preload of 30 mL.kg-1 lactated Ringer solution before surgery. Hemodynamic measurements, hemoglobin concentrations, biochemical parameters and coagulation tests were evaluated in three periods during surgical procedure. Patients received medical follow-up during their hospital stay and up to postoperative 30 days. Primary outcome was the requirement of red blood cell transfusion between groups during hospital stay. Secondary outcome were hemodynamic parameters, length of hospital stay, mortality and occurrence of clinical postoperative complications. RESULTS: Red blood cell transfusion was required in 17% of patients in the HES group and in 46% in the Ringer group (p = .029). Postoperative infections were more frequently observed in the Ringer group (17%) compared to the HES group (0), p = .037. There were no significant differences between groups in mortality, hospital length of stay and clinical complications other than infection. Conclusions: During hip arthroplasty, patients treated with hypervolemic hemodilution with hydroxyethyl starch 130/0.4 required less transfusion and presented lower infection rate compared to patients who received lactated Ringer.

JUSTIFICATIVA Y OBJETIVOS: El hidroxietilalmidón 130/0,4 (HES 130/0,4) está considerado como un expansivo plasmático efectivo cuando se le compara con los cristaloides. Existen controversias sobre su superioridad con relación a la optimización hemodinámica y sobre posibles efectos perjudiciales en la coagulación. El objetivo de este estudio, fue comparar los efectos del HES 130/0,4 con los de la solución de lactato de Ringer durante la artroplastia de cadera en pacientes adultos bajo raquianestesia, considerando el sangramiento intraoperatorio, los parámetros hemodinámicos, el coagulograma, la necesidad de transfusión y los resultados clínicos. MÉTODOS: En este estudio aleatorio y controlado, 48 pacientes citados para la artroplastia de cadera con raquianestesia fueron aleatoriamente divididos en dos grupos: 24 pacientes fueron ubicados para recibir una pre-carga de HES 130/0,4 (15 mL.kg-1) y 24 pacientes recibieron una pre-carga de solución de lactato de Ringer (30 mL.kg-1) antes de la cirugía. Las medidas hemodinámicas, concentración de hemoglobina, parámetros bioquímicos y los test de coagulación fueron evaluados en tres períodos durante el procedimiento quirúrgico. Los pacientes recibieron un acompañamiento médico durante el ingreso y de 30 días en el período del postoperatorio. El principal factor fue la necesidad de transfusión de hematíes entre los grupos durante el ingreso. Los factores secundarios fueron los parámetros hemodinámicos, tiempo de ingreso, mortalidad y aparecimiento de complicaciones clínicas. RESULTADOS: La transfusión de hematíes fue necesaria en un 17% de los pacientes del grupo HES y en un 46% de los pacientes del grupo lactato de Ringer (p = 0,029). Las infecciones postoperatorias fueron observadas con más frecuencia en el grupo lactato de Ringer (17%) en comparación con el grupo HES (0), p = 0,037. No hubo diferencias significativas entre los grupos con relación a la mortalidad, tiempo de ingreso y complicaciones clínicas, excepto en la infección. Conclusiones: Durante la artroplastia de cadera, los pacientes tratados con hemodilución hipervolémica normal con hidroxietilalmidón 130/0.4 necesitaron menos transfusión y presentaron un índice menor de infección en comparación con los pacientes que recibieron lactato de Ringer.

7726 downloads

15.

Respiratory failure after lung transplantation: extra-corporeal membrane oxygenation as a rescue treatment
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Pêgo-Fernandes, Paulo Manuel

; Hajjar, Ludhmila Abrahão

; Galas, Filomena Regina Barbosa Gomes

; Samano, Marcos Naoyuki

; Ribeiro, Alexandre Kazantzi Fonseca

; Park, Marcelo

; Soares, Rodolfo

; Osawa, Eduardo

; Jatene, Fabio Biscegli

Clinics

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dec 2012, Volume 67 N. 12 Pages 1529 - 1532

Abstract: En | Text: En | PDF: En

https://doi.org/10.6061/clinics/2012(12)32 2081 downloads

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