ABSTRACT Objective. To create and validate criteria for prioritizing problems related to policies and management of the health workforce. Methods. This methodological study was divided into three stages. First, the criteria were elaborated by means of a systematized literature review. Second, the criteria were evaluated online by a committee of judges comprised of eight specialists. In the third stage, an evaluation was carried out by the target audience in a hybrid workshop. The participants evaluated the material using the Suitability Assessment of Materials instrument, adapted for the research. Results. Three prioritization criteria (relevance, window of opportunity and acceptability) and a scoring scale were developed based on the literature review. In the evaluation by the committee of judges, the approval percentage of the criteria and prioritization method was 84%. Modifications were made based on suggestions in relation to the material presented to the specialists. In the pre-test stage, the approval percentage varied by item, with six of them reaching a maximum approval of 100% (corresponding to approximately 46% of the items), four reaching 92% and three achieving 83% each, indicating positive results. Conclusions. The developed criteria were considered valid for use in the context of policies and management in the area of human resources for health.

RESUMO Objetivo. Criar e validar critérios para priorizar problemas relacionados a políticas e gerenciamento da força de trabalho em saúde. Métodos. O presente estudo metodológico foi dividido em três fases. Primeiro, foram elaborados critérios por meio de revisão sistematizada da literatura. A seguir, os critérios foram avaliados on-line por uma comissão de juízes composta por oito especialistas. Na terceira fase, o público-alvo fez uma avaliação dos critérios em uma oficina de formato híbrido. Os participantes avaliaram o material usando o instrumento Suitability Assessment of Materials, adaptado para esta pesquisa. Resultados. Com base na revisão da literatura, foram elaborados três critérios de priorização (relevância, janela de oportunidade e aceitabilidade) e uma escala de pontuação. Na avaliação da comissão de juízes, a porcentagem de aprovação dos critérios e do método de priorização foi de 84%. Foram feitas alterações com base em sugestões relacionadas ao material apresentado aos especialistas. Na fase de pré-teste, a porcentagem de aprovação variou de acordo com o item. Seis deles (aproximadamente 46% dos itens) atingiram aprovação máxima de 100%, quatro atingiram 92% e três atingiram 83%, indicando resultados positivos. Conclusões. Os critérios desenvolvidos foram considerados válidos para uso no contexto de políticas e gerenciamento na área de recursos humanos em saúde.

RESUMEN Objetivo. Crear y validar criterios para priorizar los problemas relacionados con las políticas y la gestión de los recursos humanos para la salud. Métodos. Este estudio metodológico se dividió en tres etapas. En la primera se elaboraron los criterios mediante una revisión sistematizada de la bibliografía. En la segunda un comité de ocho especialistas evaluó en línea los criterios. Y la tercera consistió en una evaluación por parte del público destinatario en un taller híbrido. Los participantes evaluaron el material utilizando el instrumento de evaluación de la idoneidad de los materiales, que fue adaptado para la investigación. Resultados. Sobre la base de la revisión de la bibliografía, se elaboraron tres criterios para la asignación de prioridades (relevancia, ventana de oportunidad y aceptabilidad) y una escala de puntuación. En la evaluación realizada por el comité de especialistas, el porcentaje de aprobación de los criterios y del método de asignación de prioridades fue del 84%. Se realizaron modificaciones basadas en sugerencias planteadas con respecto al material presentado a los especialistas. En la etapa posterior de prueba preliminar, el porcentaje de aprobación varió en los distintos puntos, de tal manera que en seis puntos (es decir, en aproximadamente el 46% de los puntos) se alcanzó una aprobación máxima del 100%, en cuatro una aprobación del 92% y en tres una aprobación del 83% en cada uno, lo que indica unos resultados positivos. Conclusiones. Se consideró que los criterios elaborados son válidos para su uso en el contexto de las políticas y la gestión en el ámbito de los recursos humanos para la salud.

Resumo Objetivo: analisar a disponibilidade (estoque e composição) e acessibilidade (distribuição geográfica) da força de trabalho de enfermagem no Brasil. Método: estudo descritivo e transversal, com coleta retrospectiva de dados, identificados por meio da combinação de bancos de dados disponíveis em sites institucionais e estruturados de acordo com indicadores das “Contas Nacionais da Força de Trabalho em Saúde” da Organização Mundial da Saúde. Consideraram-se, para o estudo, profissionais de enfermagem de nível superior (enfermeiros) e nível médio (auxiliares e técnicos de enfermagem). Indicadores de estoque, composição, distribuição (por faixa etária e sexo) e razão de enfermeiros para médicos foram incluídos. Resultados: houve aumento no número de profissionais, entre 2005 e 2010, principalmente nos profissionais de nível médio e técnico. Há mais profissionais entre 36 e 55 anos, com predominância do sexo feminino em todas as categorias, apesar do aumento do sexo masculino. Observou-se distribuição desigual de profissionais nas regiões do país, sendo a região Sudeste a com maior número de profissionais. A razão de enfermeiros por médico é inferior a um nas regiões Sul e Sudeste. Conclusão: apesar do elevado contingente de enfermeiros, sua distribuição é desigual. O crescimento de técnicos de enfermagem superou significativamente o de enfermeiros, indicando políticas de formação técnica mais intensivas que as encontradas no ensino superior. Objetivo estoque composição geográfica Brasil Método transversal Contas Saúde Consideraramse, Consideraramse Consideraram se, se Consideraram-se (enfermeiros auxiliares enfermagem. . enfermagem) incluídos Resultados 200 2010 técnico 3 5 anos categorias masculino Observouse Observou país Conclusão 20 201 2

Abstract Objective: to analyze the availability (in terms of stock and composition) and accessibility (in terms of geographical distribution) of the nursing workforce in Brazil. Method: this is a descriptive, cross-sectional study with retrospective data collection, identified by combining databases available on institutional websites and structured according to indicators from the World Health Organization’s “National Health Workforce Accounts”. The study considered nursing professionals at senior level (nurses) and middle level (nursing auxiliaries and technicians). Indicators of stock, composition, distribution (by age group and gender) and the ratio of nurses to doctors were included. Results: there was an increase in the number of personnel between 2005 and 2010, mainly in middle and technical level professionals. There are more personnel aged between 36 and 55, with a predominance of women in all categories, despite the increase in men. There was an uneven distribution of personnel across the country’s regions, with the Southeast having the largest number of professionals. The ratio of nurses to doctors is less than one in the South and Southeast. Conclusion: despite the large number of nurses, their distribution is uneven. The growth of nursing technicians has significantly outstripped that of nurses, indicating more intensive technical training policies than those found in higher education. Objective composition Brazil Method descriptive crosssectional cross sectional collection Organizations Organization s National Accounts. Accounts . Accounts” (nurses technicians. technicians) gender included Results 200 2010 3 55 categories men countrys country regions Conclusion education 20 201 5 2

Resumen Objetivo: analizar la disponibilidad (en términos de número y composición) y accesibilidad (en términos de distribución geográfica) de la fuerza de trabajo de enfermería en Brasil. Método: estudio descriptivo y transversal, con recolección retrospectiva de datos, identificados a través de una combinación de bases de datos disponibles en sitios web institucionales y estructurados en función de los indicadores de las “Cuentas Nacionales del Personal de Salud” de la Organización Mundial de la Salud. La población del estudio fueron profesionales de enfermería de nivel superior (enfermeros) y nivel medio (auxiliares y técnicos en enfermería). Se incluyeron indicadores de número, composición, distribución (por franja etaria y sexo) y razón entre enfermeros y médicos. Resultados: aumentó el número de personal entre 2005 y 2010, principalmente la de nivel medio y técnico. La mayoría del personal tiene entre 36 y 55 años y predomina el sexo femenino en todas las categorías, pese a que aumentó la cantidad de trabajadores do sexo masculino. Se observó que la distribución de personal en las diferentes regiones de Brasil era desigual y la región Sudeste es la que tiene la mayor cantidad de profesionales. La proporción de enfermeros por médico es inferior a uno en las regiones Sur y Sudeste. Conclusión: a pesar de que la cantidad de enfermeros es elevada, la distribución es desigual. El aumento de la cantidad de técnicos en enfermería superó significativamente al de enfermeros, lo que indica que las políticas de formación técnica son más intensivas que las observadas en la educación superior. Objetivo composición geográfica Método transversal Cuentas Salud (enfermeros auxiliares enfermería. . enfermería) médicos Resultados 200 2010 técnico 3 5 categorías masculino Conclusión elevada 20 201 2

Abstract The aim of this review was to update knowledge about the prevalence of periodontitis in Latin America and the Caribbean. A critical review of was performed of all cross-sectional or cohort studies selected, pertaining to the region, and thirty-five studies conducted in 12 countries were selected. The countries with nationally representative studies were Brazil, Chile, Colombia, and Uruguay. The prevalence of periodontal disease or need for periodontal treatment varied between the different studies and countries depending on the age group, the methodology used, and the case definition. The prevalence of severe periodontitis aged between 5.8% and 49.7% in adults. In adolescents, the prevalence of moderate to severe periodontitis was 15.3%. Furthermore, a high prevalence of gingival bleeding in adolescents was reported. When analyzing the studies that used the Community Periodontal Index (CPI), Centers for Diseases Control and American Academy Periodontology (CDC/AAP) case definition, it was observed that as the age of the individuals analyzed increased, the prevalence of periodontal disease also increased. Whereas this rereview revealed that although the number of regional and nationally representative studies that analyzed the prevalence of periodontitis has risen in recent years, their methodological heterogeneity prevents global conclusions to be drawn concerning the region. Therefore, this ratifies the need to generate alliances between countries with the purpose of joining individual efforts to achieve collective goals which, among other objectives, will translate into conducting multicenter studies. These studies would allow description and monitoring of the epidemiological behavior of periodontitis in Latin America and the Caribbean. Caribbean crosssectional cross sectional selected region thirtyfive thirty five 1 Brazil Chile Colombia Uruguay group definition 58 5 8 5.8 497 49 7 49.7 adults 153 15 3 15.3% Furthermore reported CPI, CPI , (CPI) CDC/AAP CDCAAP CDC AAP (CDC/AAP increased years Therefore which objectives 5. 4 49. 15.3 (CPI 15.

Abstract Public health policies are crucial for the well-being of the general population; however, the health systems of developed countries still do not include oral health in its system. Thus, it is necessary to understand the process of decision-making in oral health policies to create opportunities for countries to achieve an overall positive health outcome, including oral health. This study aimed to identify the factors influencing the inclusion of oral health on the political agenda in Brazil, Colombia, and Chile. The study sample involved decision-makers at political, technical, and academic levels. The extracted data were analyzed using the software Maxqda® and Kingdon´s theoretical model; defining interactive variables that produce a “window of opportunity” to define the agenda and the insertion of theme in formulating public policies. The decision-making process regarding oral health is influenced by many factors like the need to improve the overall oral health of the population, identified through national epidemiological studies, and the importance of individuals in positions involving political decision-making, who advocate for oral health. Strategies were developed in partnership with the academy that focused on the health rights of the population provided by law; territorial and national programs were also developed. The inclusion and creation of oral health policies depend on actors who advocate for thematic and scientific evidence to support decision-making. A close relationship between academia and stakeholders and knowledge translation is important for the development of public policies that can be effective for health systems. wellbeing well being however system Thus decisionmaking decision making outcome Brazil Colombia Chile decisionmakers makers technical levels Maxqda Kingdons Kingdon s model window opportunity studies decisionmaking, making, law decisionmaking. making.

Resumo Fundamento A Doença de Chagas (DC) é uma causa importante de transplante cardíaco (TC). O principal obstáculo é a reativação da DC (RDC), normalmente associada a altas doses de imunossupressores. Estudos anteriores sugeriram uma associação do micofenolato de mofetila com aumento na RDC. No entanto, preditores de mortalidade são desconhecidos. Objetivos Identificar os fatores de risco de mortalidade em pacientes com DC após o TC e o impacto do regime antiproliferativo sobre a sobrevida. Métodos Estudo retrospectivo com pacientes chagásicos submetidos ao TC entre janeiro de 2004 e setembro de 2020, em protocolo de imunossupressão que priorizava o uso de azatioprina e sua mudança para micofenolato de mofetila em caso de rejeição. Realizamos regressão univariada para identificar preditores de mortalidade e comparamos sobrevida, rejeição, e evidência RDC entre os pacientes que usavam azatioprina, micofenolato de mofetila, e aqueles que mudaram de azatioprina para micofenolato (grupo “Mudança”) após a alta. Um valor de p<0,05 foi considerado estatisticamente significativo. Resultados Foram incluídos 85 pacientes, 54,1% homens, idade mediana 49 (39-57) anos, e 91,8% com prioridade na lista de espera. Dezenove (22,4%) usavam azatioprina, 37 (43,5%) micofenolato de mofetila, e 29 (34,1%) trocaram a terapia; a sobrevida não foi diferente entre os grupos, 2,9 (1,6-5,0) x 2,9 (1,8-4,8) x 4,2 (2,0-5,0) anos, respectivamente; p=0,4. Não houve diferença na taxa de rejeição (42%, 73% e 59% respectivamente; p=0,08) ou de RDC (T. cruzi positiva na biópsia endomiocárdica 5% x 11% x 7%; p=0,7; uso benzonidazol 58% x 65% x 69%; p=0,8; PCR positiva para T. cruzi 20% x 68% x 42% respectivamente; p=0,1). Conclusões Este estudo retrospectivo com pacientes com DC e TC não mostrou diferença na sobrevida entre os diferentes regimes antiproliferativos. O uso de micofenolato de mofetila não foi associado com taxas significativamente mais altas de RDC ou rejeição do enxerto nesta coorte. Novos ensaios randomizados são necessários para abordar essa questão. (DC TC. . (TC) RDC, , (RDC) imunossupressores entanto desconhecidos 200 2020 grupo Mudança “Mudança” alta p005 p 0 05 p<0,0 significativo 8 541 54 1 54,1 homens 4 3957 39 57 (39-57 anos 918 91 91,8 espera 22,4% 224 22 (22,4% 3 43,5% 435 43 5 (43,5% 2 34,1% 341 34 (34,1% terapia grupos 9 2, 1,65,0 1650 1,6 5,0 6 (1,6-5,0 1,84,8 1848 1,8 4,8 (1,8-4,8 42 4, 2,05,0 2050 2,0 (2,0-5,0 respectivamente p04 p=0,4 42%, (42% 73 59 p=0,08 p008 08 T (T 11 7% 7 p=0,7 p07 58 65 69% 69 p=0,8 p08 20 68 p=0,1. p01 p=0,1 p=0,1) antiproliferativos coorte questão (TC (RDC 202 “Mudança p00 p<0, 54, 395 (39-5 91, 22,4 (22,4 43,5 (43,5 34,1 (34,1 1,65, 165 16 1, 50 5, (1,6-5, 84 1,84, 184 18 48 (1,8-4, 2,05, 205 (2,0-5, p0 p=0, (42 p=0,0 p<0 (39- 22, (22, 43, (43, 34, (34, 1,65 (1,6-5 1,84 (1,8-4 2,05 (2,0-5 p=0 (4 p< (39 (22 (43 (34 (1,6- (1,8- (2,0- p= ( (3 (2 (1,6 (1,8 (2,0 (1, (2, (1

Abstract Background Chagas’ disease (CD) is an important cause of heart transplantation (HT). The main obstacle is Chagas’ disease reactivation (CDR), usually associated to high doses of immunosuppressants. Previous studies have suggested an association of mycophenolate mofetil with increased CDR. However, mortality predictors are unknown. Objectives To identify mortality risk factors in heart transplant patients with CD and the impact of antiproliferative regimen on survival. Methods Retrospective study with CD patients who underwent HT between January 2004 and September 2020, under immunosuppression protocol that prioritized azathioprine and change to mycophenolate mofetil in case of rejection. We performed univariate regression to identify mortality predictors; and compared survival, rejection and evidence of CDR between who received azathioprine, mycophenolate mofetil and those who changed from azathioprine to mycophenolate mofetil after discharge (“Change” group). A p-value < 0.05 was considered statistically significant. Results Eighty-five patients were included, 54.1% men, median age 49 (39-57) years, and 91.8% were given priority in waiting list. Nineteen (22.4%) used azathioprine, 37 (43.5%) mycophenolate mofetil and 29 (34.1%) switched therapy; survival was not different between groups, 2.9 (1.6-5.0) x 2.9 (1.8-4.8) x 4.2 (2.0-5.0) years, respectively; p=0.4. There was no difference in rejection (42%, 73% and 59% respectively; p=0.08) or in CDR (T. cruzi positive by endomyocardial biopsy 5% x 11% x 7%; p=0.7; benznidazole use 58% x 65% x 69%; p=0.8; positive PCR for T. cruzi 20% x 68% x 42% respectively; p=0.1) rates. Conclusions This retrospective study did not show difference in survival in heart transplant patients with CD receiving different antiproliferative regimens. Mycophenolate mofetil was not associated with statistically higher rates of CDR or graft rejection in this cohort. New randomized clinical trials are necessary to address this issue. Chagas (CD HT. . (HT) CDR, , (CDR) immunosuppressants However unknown 200 2020 Change (“Change group. group group) pvalue p value 005 0 05 0.0 significant Eightyfive Eighty five included 541 54 1 54.1 men 4 3957 39 57 (39-57 years 918 91 8 91.8 list 22.4% 224 22 (22.4% 3 43.5% 435 43 5 (43.5% 2 34.1% 341 34 (34.1% therapy groups 9 2. 1.65.0 1650 1.6 5.0 6 (1.6-5.0 1.84.8 1848 1.8 4.8 (1.8-4.8 42 4. 2.05.0 2050 2.0 (2.0-5.0 respectively p04 p=0.4 42%, (42% 73 59 p=0.08 p008 08 T (T 11 7% 7 p=0.7 p07 58 65 69% 69 p=0.8 p08 20 68 p=0.1 p01 regimens cohort issue (HT (CDR 202 00 0. 54. 395 (39-5 91. 22.4 (22.4 43.5 (43.5 34.1 (34.1 1.65. 165 16 1. 50 5. (1.6-5. 84 1.84. 184 18 48 (1.8-4. 2.05. 205 (2.0-5. p0 p=0. (42 p=0.0 p00 (39- 22. (22. 43. (43. 34. (34. 1.65 (1.6-5 1.84 (1.8-4 2.05 (2.0-5 p=0 (4 (39 (22 (43 (34 (1.6- (1.8- (2.0- p= ( (3 (2 (1.6 (1.8 (2.0 (1. (2. (1

Abstract Oral cancer is one of the most prevalent cancers in Brazil. An understanding of how public policies are implemented to address this problem can contribute to the construction of solutions. The “Programa de Melhoria do Acesso e da Qualidade” (PMAQ-AB and PMAQ-CEO) at the level of primary and secondary care are evaluations that also collect data on prevention and monitoring strategies for oral cancer. This study aimed to analyze the results of the incorporation of oral health teams to evaluate the strategies adopted by Brazil regarding the impact on the diagnosis of oral cancer. Of the 17,202 family health teams evaluated, 72.10% had oral health teams (OHT). Considering the strategies for prevention, screening, campaign, and follow-up of suspected cases, 72.27% of the campaign teams and 59.09% of the teams who accompanied suspected cases had OHT. In secondary care, more than 65% of the teams in the Southeast and South regions registered cases of oral cancer, and the referral network was more represented. The inclusion of OHT had a positive impact on campaign actions, follow-up, referral to specialists, and registration of suspected cases throughout Brazil.

This “short communication” describes the possibilities of using Teleodontology to expand and qualify health care in oral health care networks. WHO already recommended to its member countries, including Brazil, even before the pandemic, the use of Telehealth as a strategy to improve the quality of its services, especially in the context of universal health systems, as the Unified Health System In the current context, Teleodontology opens opportunities for oral health to resume the offer of various services, remotely, such as: 1. tracking, active search, monitoring users of priority groups, at risk and with systemic problems, monitoring of suspected cases of COVID-19 and its contacts, via telemonitoration; 2. initial listening, individual and collective educational activities, among others, through teleorientation; 3. discussion of clinical cases to define the opportune moment to perform operative procedures among professionals of different levels of care, matrix support, sharing and soluting doubts between professionals or between professionals and teaching and research institutions, through teleconsulting, among others . In addition to a literature review on Teleodontology in the context of the pandemic, an important contribution of this “short communication” is the conceptualization of the terms used and possibilities they offer to SUS professionals, in addition to specifying the possible protocols for recording these activities, in order to provide service managers with secure data for monitoring and evaluating the work process. In addition, we bring a brief discussion with some promising experiences, carried out in the pre- and trans-pandemic context, which can consolidate themselves as important strategies for the resumption of oral health in the post-pandemic scenario.

Este “short communication” descreve as possibilidades de utilização da Teleodontologia para ampliação e qualificação do cuidado em saúde nas redes de atenção à saúde bucal. A OMS já recomendava aos seus países membros, mesmo antes da pandemia, o Telessaúde como estratégia para melhorar a qualidade dos serviços, especialmente nos sistemas universais, como é o caso do Sistema Único de Saúde. A Teleodontologia abre oportunidades para que a saúde bucal retome a oferta de diversos serviços, de forma remota, como: 1. rastreamento, busca ativa, monitoramento de usuários prioritários, de risco e com problemas sistêmicos, de suspeitas de COVID-19 e contactantes, através do Telemonitamento; 2. escuta inicial, atividades educativas individuais ou coletivas, através da Teleorientação; 3. discussão de casos clínicos para a definição da oportunidade/necessidade de procedimentos operatórios, matriciamento, compartilhamento, solução de dúvidas entre profissionais e entre estes e instituições de ensino e pesquisa, por Teleconsultorias, entre outros. Além de uma revisão sobre a Teleodontologia no contexto da pandemia, conceituamos os termos utilizados e possibilidades que oferecem aos profissionais do SUS, além de especificar os protocolos possíveis para registro dessas atividades, a fim de fornecer dados seguros para seu monitoramento e avaliação. Ademais, trazemos uma breve discussão com experiências promissoras, realizadas nos contextos pré e trans pandemia, que podem ser importantes estratégias para a retomada da saúde bucal no cenário pós pandemia.

Abstract This paper describes the possibilities of using Teledentistry to expand and qualify health care in oral health care networks. WHO already recommended to its member countries, even before the pandemic, Telehealth as a strategy to improve the quality of services, especially in universal systems, as the Unified Health System (SUS). Teledentistry opens opportunities for oral health to resume the provision of various services, remotely, such as: 1) Tracking, active search, monitoring of priority users, those at risk and with systemic problems, suspicions of COVID-19 and contacts, through Telemonitation; 2) Initial listening, individual or collective educational activities, through Teleorientation; 3) Discussion of clinical cases for the definition of the opportunity / need for operative procedures, matrix support, sharing, solution of doubts among professionals and between these and teaching and research institutions, by Teleconsulting, among others. In addition to a review of Teledentistry in the context of the pandemic, we conceptualized the terms used and possibilities offered to SUS professionals, in addition to specifying the possible protocols for recording these activities to provide safe data for their monitoring and evaluation. Besides, we bring a brief discussion with promising experiences, carried out in the pre- and trans-pandemic contexts, which can be important strategies for the resumption of oral health in the post-pandemic scenario.

Abstract: Objective: To describe the population that reports to have visited tobacco points of sale (POS) in Argentina and their perception of tobacco advertising. Materials and methods: We used data from the 2013 National Risk Factor Survey. Results: We included 31 167 respondents (96% of the total) who attended a store that sells cigarettes in the previous 30 days. Overall, 54.1% (67.3% of current smokers, 55.1% of former smokers and 49% of non smokers) referred having seen tobacco advertising at the POS. Males (OR=1.2) and current smokers (OR=1.9 vs. non smokers) were more likely to report having seen tobacco advertising at the POS. Those who were exposed to second hand smoke in bars and restaurants (OR=1.2) were also more likely to have seen advertising. We found that younger people (age 18 - 24) were more likely to be exposed (OR=2.8 vs older than 65). Among smokers, those who referred to have seen the advertising were more likely to have tried to quit smoking during the previous year. Conclusions: It is important to regulate advertising at the POS to limit exposure, particularly among young people.

Resumen: Objetivo: Describir las características de la población que refiere haber acudido a los puntos de venta (PV) de tabaco en relación con la percepción de la publicidad en Argentina. Material y métodos: Se analizaron datos de la Encuesta Nacional de Factores de Riesgo de 2013. Resultados: Se incluyeron 31 167 encuestados que acudieron a comercios donde venden cigarrillos en los últimos 30 días. De éstos, 54.1% dijo haber visto publicidad de cigarrillos. Los varones (RM=1.2) y los fumadores actuales (RM=1.9 vs. no fumador) tuvieron más posibilidad de percibirla. Aquéllos que refirieron estar expuestos al humo de tabaco en bares y restaurantes (RM= 1.2) tuvieron más posibilidad de ver publicidad de tabaco en los puntos de venta. Hubo un gradiente en relación con la edad: los jóvenes de 18 a 24 fueron más susceptibles a referir exposición (RM=2.8 vs >65 años). Entre los fumadores, aquéllos que percibieron publicidad refirieron con mayor frecuencia haber intentado dejar de fumar en el último año. Conclusiones: Es importante que la regulación de la publicidad en los PV sea más estricta para limitar la exposición a la publicidad, particularmente en los jóvenes.

Abstract: Objective: To describe the population that reports to have visited tobacco points of sale (POS) in Argentina and their perception of tobacco advertising. Materials and methods: We used data from the 2013 National Risk Factor Survey. Results: We included 31 167 respondents (96% of the total) who attended a store that sells cigarettes in the previous 30 days. Overall, 54.1% (67.3% of current smokers, 55.1% of former smokers and 49% of non smokers) referred having seen tobacco advertising at the POS. Males (OR=1.2) and current smokers (OR=1.9 vs. non smokers) were more likely to report having seen tobacco advertising at the POS. Those who were exposed to second hand smoke in bars and restaurants (OR=1.2) were also more likely to have seen advertising. We found that younger people (age 18 - 24) were more likely to be exposed (OR=2.8 vs older than 65). Among smokers, those who referred to have seen the advertising were more likely to have tried to quit smoking during the previous year. Conclusions: It is important to regulate advertising at the POS to limit exposure, particularly among young people.

Resumen: Objetivo: Describir las características de la población que refiere haber acudido a los puntos de venta (PV) de tabaco en relación con la percepción de la publicidad en Argentina. Material y métodos: Se analizaron datos de la Encuesta Nacional de Factores de Riesgo de 2013. Resultados: Se incluyeron 31 167 encuestados que acudieron a comercios donde venden cigarrillos en los últimos 30 días. De éstos, 54.1% dijo haber visto publicidad de cigarrillos. Los varones (RM=1.2) y los fumadores actuales (RM=1.9 vs. no fumador) tuvieron más posibilidad de percibirla. Aquéllos que refirieron estar expuestos al humo de tabaco en bares y restaurantes (RM= 1.2) tuvieron más posibilidad de ver publicidad de tabaco en los puntos de venta. Hubo un gradiente en relación con la edad: los jóvenes de 18 a 24 fueron más susceptibles a referir exposición (RM=2.8 vs >65 años). Entre los fumadores, aquéllos que percibieron publicidad refirieron con mayor frecuencia haber intentado dejar de fumar en el último año. Conclusiones: Es importante que la regulación de la publicidad en los PV sea más estricta para limitar la exposición a la publicidad, particularmente en los jóvenes.

Introducción: La obesidad puede entenderse como el resultado de personas respondiendo normalmente al contexto obesogénico en el que se encuentran inmersas. Objetivo: Describir la situación epidemiológica de la obesidad y el sobrepeso en adultos y adolescentes en la Argentina. Material y métodos: Se estimó la prevalencia de obesidad y sobrepeso y factores asociados en adultos y estudiantes de 13 a 15 años a partir de datos de la Encuesta Nacional de Factores de Riesgo (ENFR) de enfermedades no transmisibles y de la Encuesta Mundial de Salud Escolar. Resultados: En 2013, la prevalencia de sobrepeso (37,1%) y de obesidad (20,8%) fue mayor que la observada en ediciones previas de la ENFR. Ambos indicadores fueron más frecuentes en varones y en personas de mayor edad. El nivel educativo y de ingresos se asoció en forma independiente con una prevalencia mayor de obesidad en mujeres. En adolescentes, en 2012, la prevalencia de sobrepeso fue del 22,8% y la de obesidad, del 5,9%. Esta última fue mayor en estudiantes con madres con primario incompleto (8,9% vs. 4,6% en hijos de mujeres con secundario completo, p = 0,002). Conclusiones: Son necesarias acciones multisectoriales de gran escala para frenar la tendencia en aumento de la epidemia de obesidad. Aunque la evidencia aún es escasa, se han propuesto varias estrategias poblacionales: campañas de comunicación y educación, regulación del precio de alimentos mediante subsidios o impuestos, etiquetado y advertencias sanitarias, regulación de la publicidad dirigida a niños y adolescentes, mejoras en el entorno alimentario escolar y laboral, reformulación de productos ultraprocesados, entre otros.

Diarrhea is a frequent and potentially severe complication of kidney transplantation. We describe here, in a cross-sectional study, the epidemiological and microbiological characteristics of acute and persistent diarrhea in 52 inpatients with kidney and kidney-pancreas transplant in a hospital in Buenos Aires, 42 (80.8%) of whom had received a kidney and 10 (19.2%) a kidney-pancreas transplant. Diarrhea was the reason of admission of 34 cases (65.4%). The etiology could be studied in 50 patients: 25 (50%) had no etiological diagnosis of diarrhea and 18 (36%) had a specific infectious etiology: 3 (6%) cytomegalovirus disease, 6 (12%) diarrhea attributed to cytomegalovirus, 5 (10%) to rotavirus and 4 (8%) to Clostridium difficile. In 7 (14%) diarrhea was attributed to drugs (mycophenolate mofetil and sirolimus). Patients with infectious diarrhea had recently received high doses of immunosuppressive therapy more frequently than the rest (p = 0.048). Those with diarrhea attributed to drugs were more frequently on mycophenolate mofetil than the rest (p = 0.039). Empirical modification of the immunosuppressive treatment was done in 16 (30.8%) and empirical antibiotic therapy was given to 47 patients (90.4%). Median length of hospital stay was 6 days. Seven patients (14.6%) persisted with diarrhea at the fifth day of admission. At hospital discharge all cases had complete resolution of symptoms and one third persisted with kidney failure. Information provided in this study can be useful as a starting point for improving preventive, diagnostic and therapeutic measures in these patients.

La diarrea es una complicación frecuente y potencialmente grave del trasplante renal. Se describen aquí, en un estudio de corte transversal, las características epidemiológicas y microbiológicas de la diarrea aguda y persistente en pacientes internados con trasplante renal o reno-páncreas. Se incluyeron 52 pacientes internados en un hospital de la Ciudad de Buenos Aires, 42 (80.8%) habían recibido un trasplante renal y 10 (19.2%) reno-páncreas. La diarrea fue el motivo de ingreso en 34 casos (65.4%). La etiología de la diarrea pudo estudiarse en 50 pacientes: en 25 (50%) no se arribó a un diagnóstico etiológico y en 18 (36%) se constató diarrea con causa microbiológica específica: 3 (6%) enfermedad por citomegalovirus, 6 (12%) diarrea atribuida a citomegalovirus, 5 (10%) a rotavirus y 4 (8%) a Clostridium difficile. En 7 (14%) la diarrea fue atribuida a fármacos (mofetil micofenolato y sirolimus). Aquellos con diarrea con causa microbiológica habían recibido recientemente inmunosupresores a altas dosis con mayor frecuencia que el resto (p = 0.048). Los pacientes con diarrea atribuida a fármacos recibían más frecuentemente mofetil micofenolato (p = 0.039). En 16 (30.8%) se realizaron modificaciones de los inmunosupresores como medida terapéutica, y a 47 (90.4%) se les indicó antibioticoterapia empírica. La mediana de duración de internación fue de 6 días y 7 pacientes (14.6%) persistieron con diarrea al quinto día. Todos tuvieron resolución de la diarrea al alta y un tercio persistió con insuficiencia renal. La información de este estudio puede servir para mejorar las medidas preventivas, diagnósticas y terapéuticas en estos pacientes.

Influenza epidemics cause not only both morbidity and mortality but also have a great socio-economic impact. Occasionally, influenza infections become pandemics, such as the case of the last influenza (H1N1) 2009 virus outbreak. Taking into account the current available evidence, and being the flu syndrome a main cause of epidemiologic impact of maximum relevance for health services managers, the evaluation of health and social resources use and its associated costs should be a priority. With the objective of addressing that need, this study was set in motion. Its research protocol is presented in this manuscript. It is an observational, longitudinal and multicentric study, that aims to compare the sanitary costs with those derived from loss of productivity; as well as to estimate the incremental costs and cost-utility of prevention and treatments interventions; in both hospitalized and outpatients. Socio-demographic and clinical variables, use of resources and health status of patients will be collected (baseline and follow-up evaluations). Analyses will be conducted from the society prospective, and incidence approach. Unitary costs will be imputed to the use frequency for the monetary assessment. Incremental costs of prevention strategies and treatments will also be calculated. Cost-utility will be estimated from the loss of utility; and also loss of quality-adjusted life years will be analyzed. Our study will contribute with original information for estimating the economic impact of flu, and help health management decision making.

Las epidemias de gripe son causa de morbi-mortalidad y tienen un gran impacto socio-económico. Ocasionalmente, los brotes de gripe generan pandemias. La última originada por el virus de la Gripe (H1N1)2009. Teniendo en cuenta la evidencia actualmente disponible y siendo la gripe una de las enfermedades de mayor impacto epidemiológico y máxima relevancia en la gestión de los servicios sanitarios, la evaluación de la utilización de recursos socio-sanitarios y sus costes asociados debería ser prioritaria. Con el objetivo de dar respuesta a esta necesidad se puso en marcha este estudio, cuyo protocolo de investigación se detalla en este manuscrito. Se trata de un estudio observacional, longitudinal y multicéntrico que pretende comparar los costes sanitarios con los derivados de la pérdida de productividad, así como estimar los costes incrementales y el coste-utilidad de las intervenciones de prevención y tratamiento, todo ello en pacientes hospitalizados y ambulatorios. Se recogerá (evaluación basal y seguimiento) información sociodemográfica, clínica, de utilización de recursos socio-sanitarios y estado de salud. Los análisis se realizarán bajo la perspectiva de la sociedad y el enfoque de la incidencia. Para la valoración monetaria se imputará el coste unitario a la frecuencia de utilización. Se calcularán los costes incrementales de las estrategias de prevención y tratamiento. El coste-utilidad se estimará a partir de la pérdida de utilidad y se analizará la pérdida global de años de vida ajustados por calidad. Nuestro estudio aportará información original que permitirá estimar el impacto económico de la gripe y ayudará en la toma de decisiones en la gestión sanitaria.