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1.
Territórios Sustentáveis e Saudáveis no SUS: a relação intrínseca com a Agenda 2030 SUS 203 20 2
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RESUMO O artigo ressalta a vital importância de integrar os Objetivos de Desenvolvimento Sustentável da Agenda 2030 no âmbito do Sistema Único de Saúde, enfatizando a necessidade de ação comunitária e cooperação para promover o desenvolvimento sustentável e a saúde. A territorialização, aliada a tecnologias sociais, é crucial, como evidenciado por iniciativas da Fundação Oswaldo Cruz, destacando a essencialidade dessa abordagem para um futuro equitativo e sustentável. 203 Saúde saúde territorialização sociais crucial Cruz 20 2
ABSTRACT This article highlights the vital importance of integrating the Sustainable Development Goals of the 2030 Agenda within the scope of the Brazilian Unified Health System, emphasizing the need for community action and cooperation to promote sustainable development and health. Territorialization, combined with social technologies, is crucial, as evidenced by initiatives from Oswaldo Cruz Foundation, highlighting the essentiality of this approach for an equitable and sustainable future. 203 System health Territorialization technologies crucial Foundation future 20 2
2.
Repercussions of the Emergency neurological life support on scientific literature: a bibliometric study literature
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Ramos, Miguel Bertelli
; Rech, Matheus Machado
; Telles, João Paulo Mota
; Moraes, Willian Medeiros
; Teixeira, Manoel Jacobsen
; Figueiredo, Eberval Gadelha
.
Resumo Antecedentes Em 2012, a Neurocritical Care Society lançou uma compilação de protocolos sobre as questões centrais que devem ser abordadas nas primeiras horas de emergências neurológicas – Emergency neurological life support (ENLS). Objetivo Avaliar a repercussão do ENLS por meio de uma análise bibliométrica. Métodos A base de dados Scopus foi utilizada em outubro de 2022 para a busca por artigos mencionando o ENLS. As seguintes variáveis foram obtidas: número de citações; número de citações por ano; número de publicações por ano; ano de publicação; tipo de pesquisa; país do autor correspondente e sua categoria de renda; revista de publicação e seu fator de impacto de 5 anos (IF); e seção onde o ENLS apareceu. Resultados Os 421 artigos incluídos foram publicados de 2012 a 2022. A média de citações por artigo foi de 17.46 (intervalo de confiança (IC) 95% = 8.20–26.72), enquanto a de citações por ano por artigo foi de 4.05 (IC95% = 2.50–5.61). O IF médio por revista foi de 5.14 (IC95% = 4.19–6.09). A maioria dos artigos era de pesquisa secundária (57.48%; n= 242/421), dos quais a maioria eram revisões narrativas (71.90%; n= 174/242). Os países de alta renda foram os mais prolíficos (80.05%; n= 337/421 artigos). Não houve publicações de países de baixa ou média renda. Conclusão Embora ainda baixo, o número de publicações mencionando o ENLS vem aumentando recentemente. A maioria dos artigos foram publicados em revistas de medicina intensiva, neurologia, neurocirurgia e medicina de emergência. Artigos de pesquisa secundária foram os mais comuns, com revisões narrativas sendo o subtipo mais frequente. . (ENLS) bibliométrica 202 obtidas (IF) apareceu 42 201 1746 17 46 17.4 intervalo IC (IC 95 8.20–26.72, 8202672 8.20–26.72 , 8 20 26 72 8.20–26.72) 405 4 05 4.0 IC95% IC95 (IC95 2.50–5.61. 250561 2.50–5.61 2 50 61 2.50–5.61) 514 14 5.1 4.19–6.09. 419609 4.19–6.09 19 6 09 4.19–6.09) 57.48% 5748 57 48 (57.48% n 242/421, 242421 242/421 242 242/421) 71.90% 7190 71 90 (71.90% 174/242. 174242 174/242 174 174/242) 80.05% 8005 80 (80.05% 337421 337 337/42 artigos. artigos) baixo recentemente intensiva neurologia emergência comuns frequente (ENLS (IF 1 17. 9 820267 8.20–26.7 7 40 0 4. IC9 (IC9 25056 2.50–5.6 51 5. 41960 4.19–6.0 57.48 574 (57.48 24242 242/42 24 71.90 719 (71.90 17424 174/24 80.05 800 (80.05 33742 33 337/4 82026 8.20–26. 2505 2.50–5. 4196 4.19–6. 57.4 (57.4 2424 242/4 71.9 (71.9 1742 174/2 80.0 (80.0 3374 3 337/ 8202 8.20–26 250 2.50–5 419 4.19–6 57. (57. 242/ 71. (71. 174/ 80. (80. 820 8.20–2 25 2.50– 41 4.19– (57 (71 (80 82 8.20– 2.50 4.19 (5 (7 (8 8.20 2.5 4.1 ( 8.2 2. 8.
Abstract Background In 2012, the Neurocritical Care Society launched a compilation of protocols regarding the core issues that should be addressed within the first hours of neurological emergencies – the Emergency neurological life support (ENLS). Objective We aim to evaluate this repercussion through a bibliometric analysis. Methods We searched Scopus on October 2022 for articles mentioning ENLS. The following variables were obtained: number of citations; number of citations per year; number of publications per year; year of publication; research type; research subtype; country of corresponding author and its income category and world region; journal of publication and its 5-year impact factor (IF); and section where ENLS appeared. Results After applying eligibility criteria, we retrieved 421 articles, published from 2012 to 2022. The mean number of citations per article was 17.46 (95% Confidence Interval (CI) = 8.20–26.72), while the mean number of citations per year per article was 4.05 (95% CI = 2.50–5.61). The mean destiny journal 5-year IF was 5.141 (95% CI = 4.189–6.093). The majority of articles were secondary research (57.48%; n= 242/421) of which most were narrative reviews (71.90%; n= 174/242). High-Income countries were the most prominent (80.05%; n= 337/421 articles). There were no papers from low-income countries. There were no trials or systematic reviews from middle-income countries. Conclusion Although still low, the number of publications mentioning ENLS is increasing. Articles were mainly published in journals of intensive care medicine, neurology, neurosurgery, and emergency medicine. Most articles were published by authors from high-income countries. The majority of papers were secondary research, with narrative review as the most frequent subtype. . (ENLS) analysis 202 obtained type subtype region 5year 5 (IF) appeared criteria 42 201 1746 17 46 17.4 95% 95 (95 (CI 8.20–26.72, 8202672 8.20–26.72 , 8 20 26 72 8.20–26.72) 405 4 05 4.0 2.50–5.61. 250561 2.50–5.61 2 50 61 2.50–5.61) 5141 141 5.14 4.189–6.093. 41896093 4.189–6.093 189 6 093 4.189–6.093) 57.48% 5748 57 48 (57.48% n 242/421 242421 242 71.90% 7190 71 90 (71.90% 174/242. 174242 174/242 174 174/242) HighIncome High Income 80.05% 8005 80 (80.05% 337421 337 337/42 articles. articles) lowincome low middleincome middle increasing medicine neurology neurosurgery highincome high (ENLS (IF 1 17. 9 (9 820267 8.20–26.7 7 40 0 4. 25056 2.50–5.6 514 14 5.1 4189609 4.189–6.09 18 09 57.48 574 (57.48 242/42 24242 24 71.90 719 (71.90 17424 174/24 80.05 800 (80.05 33742 33 337/4 ( 82026 8.20–26. 2505 2.50–5. 51 5. 418960 4.189–6.0 57.4 (57.4 242/4 2424 71.9 (71.9 1742 174/2 80.0 (80.0 3374 3 337/ 8202 8.20–26 250 2.50–5 41896 4.189–6. 57. (57. 242/ 71. (71. 174/ 80. (80. 820 8.20–2 25 2.50– 4189 4.189–6 (57 (71 (80 82 8.20– 2.50 418 4.189– (5 (7 (8 8.20 2.5 41 4.189 8.2 2. 4.18 8. 4.1
3.
Territórios Sustentáveis e Saudáveis no SUS: a relação intrínseca com a Agenda 2030
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RESUMO O artigo ressalta a vital importância de integrar os Objetivos de Desenvolvimento Sustentável da Agenda 2030 no âmbito do Sistema Único de Saúde, enfatizando a necessidade de ação comunitária e cooperação para promover o desenvolvimento sustentável e a saúde. A territorialização, aliada a tecnologias sociais, é crucial, como evidenciado por iniciativas da Fundação Oswaldo Cruz, destacando a essencialidade dessa abordagem para um futuro equitativo e sustentável.
ABSTRACT This article highlights the vital importance of integrating the Sustainable Development Goals of the 2030 Agenda within the scope of the Brazilian Unified Health System, emphasizing the need for community action and cooperation to promote sustainable development and health. Territorialization, combined with social technologies, is crucial, as evidenced by initiatives from Oswaldo Cruz Foundation, highlighting the essentiality of this approach for an equitable and sustainable future.
4.
Homocysteine serum levels in patients with ruptured and unruptured intracranial aneurysms: a case-control study aneurysms casecontrol case control
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Telles, João Paulo Mota
; Rosi Junior, Jefferson
; Yamaki, Vitor Nagai
; Rabelo, Nicollas Nunes
; Teixeira, Manoel Jacobsen
; Figueiredo, Eberval Gadelha
.
RESUMO Antecedentes Existem poucos dados sobre a influência da homocisteína na formação e rotura de aneurismas intracranianos (AI). Objetivo Comparar os níveis de homocisteína entre pacientes com AI rotos e não rotos e influências no vasoespasmo e resultados funcionais. Métodos Estudo caso-controle, que avaliou as diferenças de homocisteinemia entre pacientes com aneurismas rotos e não rotos, além da associação entre níveis de homocisteína, vasoespasmo e estado funcional. Regressões logísticas foram realizadas. Resultados Um total de 348 participantes foram incluídos: 114 (32,8%) com aneurismas rotos e 234 (67,2%) não rotos. A homocisteína mediana foi de 10,75μmol/L (IQR = 4,59) nos rotos e 11,5μmol/L (IQR = 5,84) nos não rotos. Não houve associação significativa entre os níveis de homocisteína e o status de ruptura (OR = 0,99, 95% CI = 0,96-1,04). Nem a hiperhomocisteinemia leve (>15μmol/L; OR = 1,25, 95% CI = 0,32-4,12) nem a moderada (>30μmol/L; OR = 1,0, 95% CI = 0,54-1,81) mostraram correlações significativas com aneurismas rotos. Modelos univariados (OR = 0,86; 95% CI = 0,71-1,0) e multivariados ajustados por idade (OR = 0,91; 95% CI = 0,75-1,05) não evidenciaram associação entre homocisteína e vasoespasmo. A homocisteinemia não influenciou resultados funcionais excelentes em seis meses (mRS ≤ 1) (OR = 1,04; 95% CI = 0,94-1,16). Conclusão Não houve diferenças em relação à homocisteinemia entre pacientes com aneurismas intracranianos rotos e não rotos. Em pacientes com aneurismas rotos, a homocisteinemia não foi associada ao vasoespasmo ou resultados funcionais. AI. . (AI) casocontrole, casocontrole caso controle, controle caso-controle funcional realizadas 34 incluídos 11 32,8% 328 32 8 (32,8% 23 67,2% 672 67 2 (67,2% 1075μmolL μmolL 10 75μmol L μmol IQR 4,59 459 4 59 115μmolL 5μmol 5,84 584 5 84 099 0 99 0,99 95 0,961,04. 096104 0,96 1,04 96 1 04 0,96-1,04) >15μmol/L 15μmolL 15μmol (>15μmol/L 125 25 1,25 0,324,12 032412 0,32 4,12 12 0,32-4,12 >30μmol/L 30μmolL 30μmol (>30μmol/L 1,0 0,541,81 054181 0,54 1,81 54 81 0,54-1,81 0,86 086 86 0,711,0 07110 0,71 71 0,71-1,0 0,91 091 91 0,751,05 075105 0,75 1,05 75 05 0,75-1,05 mRS 104 0,941,16. 094116 0,94 1,16 94 16 0,94-1,16) (AI 3 32,8 (32,8 67,2 6 (67,2 4,5 45 5,8 58 09 9 0,9 961 0,961,04 09610 096 0,96-1,04 1,2 324 0,324,1 03241 032 0,3 412 4,1 0,32-4,1 1, 541 0,541,8 05418 054 0,5 181 1,8 0,54-1,8 0,8 08 711 0,711, 0711 071 0,7 7 0,71-1, 751 0,751,0 07510 075 105 0,75-1,0 941 0,941,16 09411 094 116 1,1 0,94-1,16 32, (32, 67, (67, 4, 5, 0, 0,961,0 0961 0,96-1,0 0,324, 0324 03 41 0,32-4, 0,541, 0541 18 0,54-1, 0,711 07 0,71-1 0,751, 0751 0,75-1, 0,941,1 0941 0,94-1,1 (32 (67 0,961, 0,96-1, 0,324 0,32-4 0,541 0,54-1 0,71- 0,751 0,75-1 0,941, 0,94-1, (3 (6 0,961 0,96-1 0,32- 0,54- 0,75- 0,941 0,94-1 ( 0,96- 0,94-
Abstract Background There is very few data regarding homocysteine's influence on the formation and rupture of intracranial aneurysms. Objective To compare homocysteine levels between patients with ruptured and unruptured intracranial aneurysms, and to evaluate possible influences of this molecule on vasospasm and functional outcomes. Methods This is a retrospective, case-control study. We evaluated homocysteinemia differences between patients with ruptured and unruptured aneurysms; and the association of homocysteine levels with vasospasm and functional outcomes. Logistic regressions were performed. Results A total of 348 participants were included: 114 (32.8%) with previous aneurysm rupture and 234 (67.2%) with unruptured aneurysms. Median homocysteine was 10.75μmol/L (IQR = 4.59) in patients with ruptured aneurysms and 11.5μmol/L (IQR = 5.84) in patients with unruptured aneurysms. No significant association was detected between homocysteine levels and rupture status (OR = 0.99, 95% CI = 0.96-1.04). Neither mild (>15μmol/L; OR = 1.25, 95% CI 0.32-4.12) nor moderate (>30μmol/L; OR = 1.0, 95% CI = 0.54-1.81) hyperhomocysteinemia demonstrated significant correlations with ruptured aneurysms. Neither univariate (OR = 0.86; 95% CI 0.71-1.0) nor multivariable age-adjusted (OR = 0.91; 95% CI = 0.75-1.05) models evidenced an association between homocysteine levels and vasospasm. Homocysteinemia did not influence excellent functional outcomes at 6 months (mRS≤1) (OR = 1.04; 95% CI = 0.94-1.16). Conclusion There were no differences regarding homocysteinemia between patients with ruptured and unruptured intracranial aneurysms. In patients with ruptured aneurysms, homocysteinemia was not associated with vasospasm or functional outcomes. homocysteines s retrospective casecontrol case control study performed 34 included 11 32.8% 328 32 8 (32.8% 23 67.2% 672 67 2 (67.2% 1075μmolL μmolL 10 75μmol L μmol IQR 4.59 459 4 59 115μmolL 5μmol 5.84 584 5 84 099 0 99 0.99 95 0.961.04. 096104 0.96 1.04 . 96 1 04 0.96-1.04) >15μmol/L 15μmolL 15μmol (>15μmol/L 125 25 1.25 0.324.12 032412 0.32 4.12 12 0.32-4.12 >30μmol/L 30μmolL 30μmol (>30μmol/L 1.0 0.541.81 054181 0.54 1.81 54 81 0.54-1.81 0.86 086 86 0.711.0 07110 0.71 71 0.71-1.0 ageadjusted age adjusted 0.91 091 91 0.751.05 075105 0.75 1.05 75 05 0.75-1.05 mRS≤1 mRS1 mRS (mRS≤1 104 0.941.16. 094116 0.94 1.16 94 16 0.94-1.16) 3 32.8 (32.8 67.2 (67.2 4.5 45 5.8 58 09 9 0.9 961 0.961.04 09610 096 0.96-1.04 1.2 324 0.324.1 03241 032 0.3 412 4.1 0.32-4.1 1. 541 0.541.8 05418 054 0.5 181 1.8 0.54-1.8 0.8 08 711 0.711. 0711 071 0.7 7 0.71-1. 751 0.751.0 07510 075 105 0.75-1.0 mRS≤ (mRS≤ 941 0.941.16 09411 094 116 1.1 0.94-1.16 32. (32. 67. (67. 4. 5. 0. 0.961.0 0961 0.96-1.0 0.324. 0324 03 41 0.32-4. 0.541. 0541 18 0.54-1. 0.711 07 0.71-1 0.751. 0751 0.75-1. (mRS 0.941.1 0941 0.94-1.1 (32 (67 0.961. 0.96-1. 0.324 0.32-4 0.541 0.54-1 0.71- 0.751 0.75-1 0.941. 0.94-1. (3 (6 0.961 0.96-1 0.32- 0.54- 0.75- 0.941 0.94-1 ( 0.96- 0.94-
5.
Streptococcus equi subspecies zooepidemicus: an emergent cause of meningoencephalitis in Northeastern Brazil zooepidemicus
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Farias, Luis Arthur Brasil Gadelha
; Sousa, Marcos Maciel
; Cavalcante, Karene Ferreira
; Jucá, Marina Pinheiro Catunda
; Castro, Aldenise de Olinda
; Mello, Liana Perdigão
; Mesquita, Rafael Ferreira
; Bandeira, Silviane Praciano
; Marchi, Ana Paula
; Coelho, Tânia Mara Silva
; Lima Neto, Antônio Silva
; Arruda, Érico Antonio Gomes de
; Costa, Silvia Figueiredo
; Oliveira, Maura Salaroli de
; Perdigão Neto, Lauro Vieira
.
Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT This study describes an outbreak of Streptococcus equi subspecies zooepidemicus infections that caused meningoencephalitis and bacteremia related to unpasteurized milk consumption in northeastern Brazil. Epidemiological investigations and a brief literature review were conducted. Strains with possible neurotropism had not been identified in Brazil before these cases; however, in 2023, another case of meningoencephalitis caused by Streptococcus equi sp. zooepidemicus was described, revealing the need to maintain surveillance and highlighting that these neurotropic strains continue to circulate in the environment. conducted cases however 2023 sp described environment 202 20 2
6.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
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; Molina, Flavio B.
; Passos, Flávio D.
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; Justo, Marcia C.N.
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; Bologna, Marco A.
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; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
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; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
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; Hamada, Neusa
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; Evangelista, Olivia
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; Silva, Paula K.R.
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; Corgosinho, Paulo H.C.
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; Boldrini, Rafael
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; Sepulveda, Tatiana A.
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ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
7.
Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and prognosis after aneurysmal subarachnoid hemorrhage: a cohort study Neutrophiltolymphocyte Neutrophil to lymphocyte platelettolymphocyte platelet hemorrhage
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Oliveira, Adilson Jose Manuel de
; Rabelo, Nicollas Nunes
; Telles, João Paulo Mota
; Solla, Davi Jorge Fontoura
; Coelho, Antonio Carlos Samaia da Silva
; Barbosa, Guilherme Bitencourt
; Barbato, Natália Camargo
; Yoshikawa, Marcia Harumy
; Teixeira, Manoel Jacobsen
; Figueiredo, Eberval Gadelha
.
Resumo Antecedentes O prognóstico da hemorragia subaracnoidea (HSA) permanece ruim. Vasoespasmo pode estar associado à inflamação. Razões neutrófilo-linfócito (NLR) e plaqueta-linfócito (PLR) têm sido estudadas como marcadores de inflamação e prognóstico. Objetivo Investigar NLR e PLR na admissão como preditores de vasoespasmo angiográfico e desfecho aos 6 meses. Métodos Este estudo de coorte incluiu pacientes consecutivos com HSA aneurismática de um centro terciário. Contagem de leucócitos, neutrófilos, linfócitos e plaquetas, proporção de neutrófilos para linfócitos e de plaquetas para linfócitos foram coletados como variáveis independentes. Ocorrência de vasoespasmo, escala de Rankin modificada, escala de desfecho de Glasgow e o escore de Hunt-Hess na admissão e 6 meses após a mesma foram registradas como variáveis dependentes. Modelos de regressão logística multivariável foram usados para ajustar potenciais fatores de confusão e avaliar valor prognóstico independente de NLR e PLR. Resultados Um total de 74,1% pacientes eram do sexo feminino, com idade média de 55,6 ± 12,4 anos. Na admissão, a pontuação média de Hunt-Hess foi de 2 (IQR 1) e a mediana de mFisher foi de 3 (IQR 1). Clipagem microcirúrgica foi o tratamento escolhido para 66,2% dos pacientes. A incidência de vasoespasmo angiográfico foi de 16,5%. Aos 6 meses, a escala de desfecho de Glasgow mediana era 4 (IQR 0,75) e a escala de Rankin modificada mediana era 3 (IQR 1,5). Vinte e um pacientes (15,1%) morreram. Os níveis de NLR e PLR não diferiram entre resultados funcionais favoráveis e desfavoráveis (mRS > 2 ou GOS < 4). Nenhuma variável foi significativamente associada ao vasoespasmo angiográfico. Conclusão Razão neutrófilo-linfócito e a PLR não apresentaram valor preditivo de desfecho funcional ou risco de vasoespasmo angiográfico. Mais pesquisas são necessárias neste campo. (HSA ruim neutrófilolinfócito neutrófilo linfócito (NLR plaquetalinfócito plaqueta (PLR terciário leucócitos independentes HuntHess Hunt Hess dependentes 741 74 1 74,1 feminino 556 55 55, 124 12 12, anos IQR 1. . 662 66 66,2 165 16 5 16,5% 0,75 075 0 75 1,5. 15 1,5 1,5) 15,1% 151 (15,1% morreram mRS 4. 4) campo 7 74, 66, 16,5 0,7 07 1, 15,1 (15,1 16, 0, 15, (15, (15 (1 (
Abstract Background Subarachnoid hemorrhage (SAH) prognosis remains poor. Vasospasm mechanism might be associated with inflammation. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been studied as inflammation markers and prognostic predictors. Objective We aimed to investigate NLR and PLR in admission as predictors of angiographic vasospasm and functional outcome at 6 months. Methods This cohort study included consecutive aneurysmal SAH patients admitted to a tertiary center. Complete blood count was recorded at admission before treatment. White blood cell count, neutrophil count, lymphocyte count, platelet count, NLR, and PLR were collected as independent variables. Vasospasm occurrence-modified Rankin scale (mRS), Glasgow outcome scale (GOS), and Hunt-Hess score at admission and at 6 months were recorded as dependent variables. Multivariable logistic regression models were used to adjust for potential confounding and to assess the independent prognostic value of NLR and PLR at admission. Results A total of 74.1% of the patients were female, with mean age of 55.6 ± 12.4 years. At admission, the median Hunt-Hess score was 2 (interquartile range [IQR] 1), and the median mFisher was 3 (IQR 1). Microsurgical clipping was the treatment for 66.2% of the patients. Angiographic vasospasm incidence was 16.5%. At 6 months, the median GOS was 4 (IQR 0.75), and the median mRS was 3 (IQR 1.5). Twenty-one patients (15.1%) died. Neutrophil-to-lymphocyte ratio and PLR levels did not differ between favorable and unfavorable (mRS > 2 or GOS < 4) functional outcomes. No variables were significantly associated with angiographic vasospasm. Conclusion Admission NLR and PLR presented no value for prediction of functional outcome or angiographic vasospasm risk. Further research is needed in this field. (SAH poor Neutrophiltolymphocyte Neutrophil (NLR platelettolymphocyte (PLR center occurrencemodified occurrence modified mRS, , (mRS) GOS, (GOS) HuntHess Hunt Hess 741 74 1 74.1 female 556 55 55. 124 12 12. years interquartile IQR [IQR 1, 1) 1. . 662 66 66.2 165 16 5 16.5% 0.75, 075 0.75 0 75 0.75) 1.5. 15 1.5 1.5) Twentyone Twenty one 15.1% 151 (15.1% died outcomes risk field (GOS 7 74. 66. 16.5 07 0.7 15.1 (15.1 16. 0. 15. (15. (15 (1 (
8.
[SciELO Preprints] - THE TEACHING THROUGH RESEARCH AND THE LIBERATING PEDAGOGY OF PAULO FREIRE: ANALYZING POSSIBLE PEDAGOGIC ARTICULATIONS
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Investigative teaching and Freirean pedagogy are teaching perspectives that, despite having started from different origins and contexts, with equally different purposes and having, to a certain extent, have been proposed to meet specific audiences and demands, it is possible to stablish articulations between their constructs. Thus, this paper proposes an analysis of these pedagogical articulations and intends to contribute to the discussions around teaching and learning science in contemporary times. For this analysis, common structuring elements between both proposals were selected, namely: the problem conception and problematization; the mobilization of prior knowledge; teacher mediation; the position occupied by the students and the intellectual freedom offered to such subjects and; the learning assessment process. The aforementioned analysis pointed to some approximations, especially with regard to the understanding around the problematization (covering the historical and social contextualization of such themes involved), the autonomy and valorization of previous knowledge, admittedly important for the genesis of knowledge in both perspectives . Also with regard to learning assessment procedures, both recommend that instruments be thought up that are able to involve students in this evaluative-formative process of recognition of potentialities/weaknesses and reframing of the error. It is argued, therefore, that investigative activities, in line with the Freirean perspective, may contribute to the scientific literacy process of students, by stimulating their active participation, argumentation, the development of cognitive skills, but, above all, involvement in scientific practices that problematize the reality in which they are inserted.
La enseñanza investigativa y la pedagogía freireana son perspectivas didácticas que, a pesar de haber partido de orígenes y contextos diferentes, con propósitos igualmente diversos y, en cierta medida, planteadas para atender a públicos y demandas específicas, pueden establecer articulaciones entre sus constructos. De mamera que este artículo propone un análisis de esas articulaciones pedagógicas, con la intención de contribuir a las discusiones en torno a la enseñanza y el aprendizaje de las ciencias en la contemporaneidad. Para este análisis, se seleccionaron elementos estructurantes comunes entre ambas propuestas, siendo estos: la concepción del problema y la problematización; la movilización de conocimientos previos; la mediación docente; la posición que ocupan los estudiantes y la libertad intelectual ofrecida a estos sujetos y; el proceso de evaluación del aprendizaje. El análisis mencionado apuntó para algunas aproximaciones, especialmente en lo que se refiere a la comprensión en torno de la problematización (abarcando la contextualización histórica y social de los temas involucrados), de la autonomía y valorización de los saberes previos, sin duda importantes para la génesis del conocimiento en ambas las perspectivas. También en lo que dice respecto a los procedimientos de evaluación del aprendizaje, ambos recomiendan que sean pensados instrumentos que sean capaces de involucrar a los estudiantes en este proceso evaluativo-formativo, de reconocimiento de potencialidades/debilidades y reformular el error. Defiéndese, por lo tanto, que las actividades investigativas, en línea con la perspectiva freireana, pueden contribuir con el proceso de alfabetización científica de los estudiantes, al estimular su participación activa, la argumentación, el desarrollo de habilidades cognitivas, pero, sobre todo, el involucramiento en las prácticas científicas que problematizan la realidad en la que se insertan.
O ensino investigativo e a pedagogia freiriana são perspectivas de ensino que, apesar de terem partido de origens e contextos distintos, com propósitos igualmente diversos e terem, em certa medida, sido propostas para atender a públicos e demandas específicas, pode-se estabelecer solidários entre seus construtos. De modo que o presente artigo propõe análise a estas discussões pedagógicas, pretendendo contribuir com as discussões em torno do ensino e aprender ciências na contemporaneidade. Para esta análise, foram selecionados elementos estruturantes comuns entre ambas as propostas, sendo estes: a concepção de problema e problematização; a mobilização de conhecimentos prévios; a mediação docente;a posição ocupada pelos discentes e a liberdade intelectual oferecida a estes sujeitos e; o processo de avaliação da aprendizagem. A análise apontada apontou para algumas aproximações, especialmente no que diz respeito ao entendimento em torno da problematização (abrangendo a contextualização histórica e social dos temas envolvidos), da autonomia e preservação dos saberes prévios, reconhecidamente importantes para a gênese de conhecimentos em ambas as perspectivas . Também não que diga respeito aos procedimentos de avaliação da aprendizagem, ambos recomendam que sejam instrumentos pensados que consigam envolver os alunos neste processo avaliativo-formativo, de reconhecimento de potencialidades/fragilidades e ressignificação do erro.Defende-se, portanto, que atividades investigativas, espontâneos à perspectiva freiriana, podem contribuir com o processo de alfabetização científica dos estudantes, por estimular-lhes a participação ativa, a argumentação, o desenvolvimento de habilidades cognitivas, mas, sobretudo, o envolvimento em práticas científicas que problematizam a realidade em que estão inseridos.
9.
Role of temporary arterial occlusion in subarachnoid hemorrhage outcomes: a prospective cohort study outcomes
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Yoshikawa, Marcia Harumy
; Rabelo, Nícollas Nunes
; Telles, João Paulo Mota
; Pipek, Leonardo Zumerkorn
; Barbosa, Guilherme Bitencourt
; Barbato, Natália Camargo
; Coelho, Antônio Carlos Samaia da Silva
; Teixeira, Manoel Jacobsen
; Figueiredo, Eberval Gadelha
.
ABSTRACT Purpose: Temporary arterial occlusion (TAO) is a widespread practice in the surgical treatment of intracranial aneurysms. This study aimed to investigate TAO’s role during ruptured aneurysm clipping as an independent prognostic factor on short- and long-term outcomes. Methods: This prospective cohort included 180 patients with ruptured intracranial aneurysms and an indication of microsurgical treatment. Patients who died in the first 12 hours after admission were excluded. Results: TAO was associated with intraoperative rupture (IOR) (odds ratio – OR = 10.54; 95% confidence interval – 95%CI 4.72–23.55; p < 0.001) and surgical complications (OR = 2.14; 95%CI 1.11–4.07; p = 0.01). The group with TAO and IOR had no significant difference in clinical (p = 0.06) and surgical (p = 0.94) complications compared to the group that had TAO, but no IOR. Among the 111 patients followed six months after treatment, IOR, number of occlusions, and total time of occlusion were not associated with Glasgow Outcome Scale (GOS) in the follow-up (respectively, p = 0.18, p = 0.30, and p = 0.73). Among patients who underwent TAO, IOR was also not associated with GOS in the follow-up (p = 0.29). Conclusions: TAO was associated with IOR and surgical complications, being the latter independent of IOR occurrence. In long-term analysis, neither TAO nor IOR were associated with poor clinical outcomes. Purpose (TAO TAOs s short longterm long term outcomes Methods 18 1 excluded Results (IOR odds 10.54 1054 10 54 95 95CI CI 4.72–23.55 4722355 4 72 23 55 0.001 0001 0 001 2.14 214 2 14 1.11–4.07 111407 11 07 0.01. 0.01 . 01 0.01) 0.06 006 06 0.94 094 94 occlusions (GOS followup follow up respectively, respectively (respectively 018 0.18 030 30 0.30 0.73. 073 0.73 73 0.73) 0.29. 029 0.29 29 0.29) Conclusions occurrence analysis 10.5 105 5 9 4.72–23.5 472235 7 0.00 000 00 2.1 21 1.11–4.0 11140 0.0 0.9 09 0.1 03 3 0.3 0.7 02 0.2 10. 4.72–23. 47223 2. 1.11–4. 1114 0. 4.72–23 4722 1.11–4 4.72–2 472 1.11– 4.72– 47 1.11 4.72 1.1 4.7 1. 4.
10.
A fatal case of COVID-19-associated meningoencephalitis in a patient coinfected with influenza A COVID19associated COVIDassociated COVID 19 associated 1
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Farias, Luís Arthur Brasil Gadelha
; Silva, Francisco José Cândido da
; Maia, Kelma Maria
; Cavalcante, Karene Ferreira
; Damasceno, Lisandra Serra
.
Revista do Instituto de Medicina Tropical de São Paulo
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ABSTRACT We report a case of COVID-19-associated meningoencephalitis with a fatal outcome in a male patient with concomitant influenza A, who had been hospitalized at the beginning of 2022, in the Northeastern region of Brazil. He died due to cardiopulmonary arrest after developing status epilepticus on the third day of hospitalization. The SARS-CoV-2 RNA was detected in cerebrospinal fluid and Influenza A was detected in the nasopharyngeal swab. Meningoencephalitis due to COVID-19 is a rare manifestation and physicians must be aware of this complication, mainly during the pandemic. In viral co-circulation situations, the possibility of respiratory coinfections should be remembered. COVID19associated COVIDassociated COVID 19 associated 2022 Brazil hospitalization SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- swab COVID19 COVID-1 complication pandemic cocirculation co circulation situations remembered 1 202 SARS-CoV COVID1 COVID- 20
11.
Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample Adolescence
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Cunha, Graccielle R.
; Caye, Arthur
; Pan, Pedro
; Fisher, Helen L.
; Pereira, Rivka
; Ziebold, Carolina
; Bressan, Rodrigo
; Miguel, Eurípedes Constantino
; Salum, Giovanni A.
; Rohde, Luis Augusto
; Kohrt, Brandon A.
; Mondelli, Valeria
; Kieling, Christian
; Gadelha, Ary
.
Objective: The Identifying Depression Early in Adolescence Risk Score (IDEA-RS) was recently developed in Brazil using data from the Pelotas 1993 Birth Cohort to estimate the individualized probability of developing depression in adolescence. This model includes 11 sociodemographic variables and has been assessed in longitudinal studies from four other countries. We aimed to test the performance of IDEA-RS in an independent, community-based, school-attending sample within the same country: the Brazilian High-Risk Cohort. Methods: Standard external validation, refitted, and case mix-corrected models were used to predict depression among 1442 youth followed from a mean age of 13.5 years at baseline to 17.7 years at follow-up, using probabilities calculated with IDEA-RS coefficients. Results: The area under the curve was 0.65 for standard external validation, 0.70 for the case mix-corrected model, and 0.69 for the refitted model, with discrimination consistently above chance for predicting depression in the new dataset. There was some degree of miscalibration, corrected by model refitting (calibration-in-the-large reduced from 0.77 to 0). Conclusion: IDEA-RS was able to parse individuals with higher or lower probability of developing depression beyond chance in an independent Brazilian sample. Further steps should include model improvements and additional studies in populations with high levels of subclinical symptoms to improve clinical decision making. Objective IDEARS IDEA RS (IDEA-RS 199 adolescence 1 countries communitybased, communitybased community based, based community-based schoolattending school attending country HighRisk High Methods validation mixcorrected mix 144 135 13 5 13. 177 17 7 17. followup, followup follow up, up follow-up coefficients Results 065 0 65 0.6 070 70 0.7 069 69 dataset miscalibration calibrationinthelarge calibration large 077 77 0. . 0) Conclusion making 19 14 06 6 07
12.
Chitosan microparticles loaded with essential oils inhibit duo-biofilms of Candida albicans and Streptococcus mutans duobiofilms duo biofilms
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GARCIA, Lana Glerieide Silva
; ROCHA, Maria Gleiciane da
; FREIRE, Rosemayre Souza
; NUNES, Paulo Iury Gomes
; NUNES, João Victor Serra
; FERNANDES, Mirele Rodrigues
; PEREIRA-NETO, Waldemiro Aquino
; SIDRIM, José Júlio Costa
; SANTOS, Flavia Almeida
; ROCHA, Marcos Fábio Gadelha
; RODRIGUES, Lidiany Karla Azevedo
; VIEIRA, Rodrigo Silveira
; BRILHANTE, Raimunda Sâmia Nogueira
.
Abstract Oral candidiasis is a common fungal infection that affects the oral mucosa, and happens when Candida albicans interacts with bacteria in the oral microbiota, such as Streptococcus mutans, causing severe early childhood caries. C. albicans and S. mutans mixed biofilms are challenging to treat with conventional antimicrobial therapies, thus, new anti-infective drugs are required. Objective This study aimed to test a drug delivery system based on chitosan microparticles loaded with geranium and lemongrass essential oils to inhibit C. albicans and S. mutans mixed biofilms. Methodology Chitosan microparticles loaded with essential oils (CM-EOs) were obtained by spray-drying. Susceptibility of planktonic were performed according CLSI at 4 to 2,048 µg/mL. Mixed biofilms were incubated at 37ºC for 48 h and exposed to CM-EOs at 256 to 4,096 µg/mL. The antimicrobial effect was evaluated using the MTT assay, with biofilm architectural changes analyzed by scanning electron microscopy. RAW 264.7 cell was used to evaluate compound cytotoxicity. Results CM-EOs had better planktonic activity against C. albicans than S. mutans. All samples reduced the metabolic activity of mixed C. albicans and S. mutans biofilms, with encapsulated oils showing better activity than raw chitosan or oils. The microparticles reduced the biofilm on the slides. The essential oils showed cytotoxic effects against RAW 264.7 cells, but encapsulation into chitosan microparticles decreased their toxicity. Conclusion This study demonstrates that chitosan loaded with essential oils may provide an alternative method for treating diseases caused by C. albicans and S. mutans mixed biofilm, such as dental caries. mucosa microbiota caries C S therapies thus antiinfective anti infective required CMEOs CM EOs (CM-EOs spraydrying. spraydrying spray drying. drying spray-drying 2048 2 048 2,04 µgmL µg mL µg/mL ºC 25 4096 096 4,09 assay microscopy 2647 264 7 264. cytotoxicity slides cells toxicity 204 04 2,0 409 09 4,0 26 20 0 2, 40 4,
13.
Streptococcus constellatus causing concomitant extra and intracranial abscesses complicated with sagittal sinus thrombosis
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Farias, Luís Arthur Brasil Gadelha
; Firmino, Natália Nogueira
; Sousa, Marcos Maciel
; Lira, Mateus Lavor
; Meireles, Leonardo Nogueira
; Stolp, Ângela Maria Veras
; Maia, Kelma Maria
; Costa, Silvia Figueiredo
; Perdigão Neto, Lauro Vieira
.
Revista do Instituto de Medicina Tropical de São Paulo
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ABSTRACT Streptococcus constellatus is a gram-positive coccus member of the Streptococcus anginosus group (SAG). It can be found in the oral flora, and may cause abscess more commonly in the gastrointestinal tract, lungs, and heart. Brain abscesses are severe neurological infections with high mortality rates. Streptococcus species other than S. pneumoniae are rare causes of brain abscesses. This case report highlights a severe case of extra and intracranial abscesses due to S. constellatus in an immunocompetent host grampositive gram positive SAG. SAG . (SAG) flora tract lungs heart rates S (SAG
14.
Diretriz Brasileira de Dispositivos Cardíacos Eletrônicos Implantáveis – 2023 202 20 2
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Teixeira, Ricardo Alkmim
; Fagundes, Alexsandro Alves
; Baggio Junior, José Mário
; Oliveira, Júlio César de
; Medeiros, Paulo de Tarso Jorge
; Valdigem, Bruno Pereira
; Teno, Luiz Antônio Castilho
; Silva, Rodrigo Tavares
; Melo, Celso Salgado de
; Elias Neto, Jorge
; Moraes Júnior, Antonio Vitor
; Pedrosa, Anisio Alexandre Andrade
; Porto, Fernando Mello
; Brito Júnior, Hélio Lima de
; Souza, Thiago Gonçalves Schroder e
; Mateos, José Carlos Pachón
; Moraes, Luis Gustavo Belo de
; Forno, Alexander Romeno Janner Dal
; D’Avila, Andre Luiz Buchele
; Cavaco, Diogo Alberto de Magalhães
; Kuniyoshi, Ricardo Ryoshim
; Pimentel, Mauricio
; Camanho, Luiz Eduardo Montenegro
; Saad, Eduardo Benchimol
; Zimerman, Leandro Ioschpe
; Oliveira, Eduardo Bartholomay
; Scanavacca, Mauricio Ibrahim
; Martinelli Filho, Martino
; Lima, Carlos Eduardo Batista de
; Peixoto, Giselle de Lima
; Darrieux, Francisco Carlos da Costa
; Duarte, Jussara de Oliveira Pinheiro
; Galvão Filho, Silas dos Santos
; Costa, Eduardo Rodrigues Bento
; Mateo, Enrique Indalécio Pachón
; Melo, Sissy Lara De
; Rodrigues, Thiago da Rocha
; Rocha, Eduardo Arrais
; Hachul, Denise Tessariol
; Lorga Filho, Adalberto Menezes
; Nishioka, Silvana Angelina D’Orio
; Gadelha, Eduardo Barreto
; Costa, Roberto
; Andrade, Veridiana Silva de
; Torres, Gustavo Gomes
; Oliveira Neto, Nestor Rodrigues de
; Lucchese, Fernando Antonio
; Murad, Henrique
; Wanderley Neto, José
; Brofman, Paulo Roberto Slud
; Almeida, Rui M. S.
; Leal, João Carlos Ferreira
.
15.
Clozapine prescription trends in Brazil in the last decade
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Massuda, Raffael
; Gama, Clarissa S.
; Belmonte-de-Abreu, Paulo
; Elkis, Helio
; de Lucena, David Freitas
; Bressan, Rodrigo
; Noto, Cristiano
; Gadelha, Ary
.
Objective: Clozapine is a second-generation antipsychotic indicated for treatment-resistant schizophrenia. Studies in several countries have shown a low rate of clozapine use despite the fact that approximately 30% of schizophrenia cases are treatment-resistant. In Brazil, few studies have addressed the frequency and variety of antipsychotic use in individuals diagnosed with schizophrenia (ICD F20). The objective of this study was to measure the rates of clozapine use in this population in the last decade using Brazilian Ministry of Health data. Methods: Prescriptions made between 2010 and 2020 in all 26 states and the Federal District registered at the Outpatient Information System Database from the Brazilian Health System (SIASUS) were evaluated. Results: A total of 25,143,524 prescriptions were recorded in this period, with clozapine representing 8.86% of all antipsychotics. The most frequently prescribed antipsychotic for patients with schizophrenia was olanzapine (35.8%), followed by quetiapine (27.5%). From 2010 to 2020, the rate of clozapine prescriptions in Brazil increased from 7.2% to 10.9%. Conclusions: Despite a slight increase in prescriptions in the last decade, clozapine is still underutilized in Brazil.
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