Abstract. - The present paper exposes the feasibility of producing particleboards with wastes from the cotton industry in northeastern Argentina, agglomerated with urea-formaldehyde resin, as an alternative to replace wood with lower-cost lignocellulosic waste, for there are no measures to achieve an efficient final disposal. The aim is to achieve particleboards suitable for the construction of housing enclosures and simple furniture. With the intention of optimizing boards behavior, the influence of the particle size distribution and their morphological characteristics on the mechanical properties, water resistance, and final quality of the boards is investigated. Three situations are compared: unclassified milled material, classified milled material, and classified remilled material, which constitutes single-layer boards with resin percentages of 11.9 %, 15.1 %, and 19.3 %. Results show that the use of finer particles increases the flexural strength (MOR) and the modulus of elasticity (MOE) by approximately 35 % compared to boards where larger particles are used. Swelling and water absorption decrease between 25 % and 70 % by using smaller particles. Boards made with smaller particles achieve better resin impregnation and simpler mixing processes, which result in better-cut quality and smoother surfaces. These results contribute to the identification of a final disposal with added value for abundant waste and an alternative raw material that can replace wood in the board manufacturing process.

Resumen. - El presente trabajo expone la posibilidad de generar tableros de partículas con residuos de la industria algodonera del noreste de Argentina, aglomerados con resina urea-formaldehído, como una alternativa de sustitución de la madera por desechos lignocelulósicos de menor costo, para los cuales aún no se han implementado medidas para lograr una disposición final eficiente. Se pretende lograr tableros de partículas que puedan ser utilizados en la construcción de cerramientos de viviendas y mobiliario sencillo. Con la intención de optimizar el comportamiento de estos tableros, se investiga la influencia de la distribución de tamaños de partículas y sus características morfológicas en las propiedades mecánicas, resistencia al agua y calidad final de los tableros. Se comparan tres situaciones: material molido sin clasificar, material molido clasificado y material remolido clasificado, que conforman tableros monocapa con porcentajes de resina de 11,9 %, 15,1 % y 19,3 %. Los resultados muestran que el uso de partículas más finas aumenta aproximadamente un 35% la resistencia a la flexión (MOR) y el módulo de elasticidad (MOE) en comparación con tableros donde se utilizan partículas más grandes. El hinchamiento y la absorción de agua disminuyen entre 25% y 70% utilizando partículas más pequeñas. Los tableros elaborados con partículas más pequeñas logran una mejor impregnación de la resina y procesos de mezclado más sencillos, que redundan en una mejor calidad de corte y superficies más lisas. Estos resultados contribuyen a la identificación de una disposición final de un residuo abundante sumando valor agregado y de alternativas de materias primas que puedan reemplazar a la madera en el proceso de fabricación de tableros.

RESUMEN Objetivos: Determinar los diagnósticos psiquiátricos y describir características clínicas, el riesgo biopsicosocial y los tratamientos de las pacientes hospitalizadas en el servicio de alto riesgo obstétrico para las que se realizó una interconsulta con psiquiatría. Métodos: Estudio observacional descriptivo en el que se incluyó a las pacientes del servicio de alto riesgo obstétrico de una institución de alta complejidad de Medellín para las que se interconsultó por psiquiatría de enlace entre 2013 y 2017. Las principales variables de interés fueron los diagnósticos y tratamientos tanto psiquiátricos como gineco obstétricos, además de los factores de riesgo obstétricos y psicosociales. Resultados: Se cribaron en total 361 historias clínicas, y 248 pacientes cumplían los criterios de inclusión. El diagnóstico psiquiátrico principal más prevalente fue trastorno depresivo mayor (29%), seguido por el trastorno de adaptación (21,8%) y los trastornos de ansiedad (12,5%); los fármacos más prescritos por psiquiatría fueron antidepresivos ISRS (24,2%), trazodona (6,8%) y benzodiacepinas (5,2%). El diagnóstico obstétrico principal más común fue el parto espontáneo (46,4%) y los diagnósticos obstétricos secundarios que predominaron fueron trastorno hipertensivo asociado con el embarazo (10,4%), diabetes gestacional (9,2%) y abortos recurrentes (6,4%). El 71,8% de las pacientes tenían un riesgo biopsicosocial alto. Conclusiones: Los principales diagnósticos psiquiátricos fueron trastorno depresivo mayor, trastorno de adaptación y trastornos de ansiedad, lo que implica la importancia del oportuno reconocimiento en la evaluación prenatal de los síntomas de estas entidades, conjuntamente con los factores de riesgo obstétrico y social. La intervención psiquiátrica es necesaria considerando las implicaciones negativas que tiene el alto riesgo tanto para la madre como paraelniño.

ABSTRACT Objective To determine the psychiatric diagnoses and treatments of patients admitted to the high-risk obstetric service who underwent a consultation with a liaison psychiatrist. Methods: A descriptive observational study that included pregnant women from the high-risk obstetric service of a highly specialised clinic in Medellín, who had a liaison psychiatry consultation between 2013 and 2017. The main variables of interest were psychiatric and obstetric diagnoses and treatments, in addition to biopsychosocial risk factors. Results: A total of 361 medical records were screened, with 248 patients meeting the inclusion criteria. The main prevailing psychiatric diagnosis was major depressive disorder (29%), followed by adaptive disorder (21.8%) and anxiety disorders (12.5%). The pharmacologic treatments most used by the psychiatry service were SSRI antidepressants (24.2%), trazodone (6.8%) and benzodiazepines (5.2%). The most common primary obstetric diagnosis was spontaneous delivery (46.4%), and the predominant secondary obstetric diagnoses were hypertensive disorder associated with pregnancy (10.4%), gestational diabetes (9.2%) and recurrent abortions (6.4%). Overall, 71.8% of the patients had a high biopsychosocial risk. Conclusions: The studied population's primary psychiatric disorders were major depressive disorder, adjustment disorder and anxiety disorders, which implies the importance of timely recognition of the symptoms of these perinatal mental pathologies, together with obstetric and social risks, in the prenatal consultation. Psychiatric intervention should be encouraged considering the negative implications of high biopsychosocial risk in both mothers and children.

Abstract This observational study aimed to describe and analyze data from two external evaluations of the National Program for Improving Access to and Quality of Dental Specialty Centers (PMAQ CEO), held in 2014 and 2018 in Brazil, which evaluated Dental Specialty Centers (CEO) using a national and census approach. We selected questions through a search in the microdata of the first and second evaluations. The groups were analyzed independently. To compare the groups, nonparametric tests were performed (Mann Whitney U). The formulated hypotheses were: there would be no differences between the data of these groups (h0) and there would be differences between the data of these groups (h1). For qualitative nominal variables, frequency distribution was verified and association tests were performed (chi-square test). The significance level for this study was set at 5%. We observed that orthodontic treatments were found in about 13% of the CEO. Regarding human resources, most professionals were specialists or had MSc or PhD degrees; were civil servants; had been hired by direct administration; or had been hired via public tender. Regarding the work process and inclusion of the CEO in the health care network, we observed a greater number of services that use single and electronic medical records, greater presence of services monitoring and analyzing goals, greater knowledge about monthly average of absenteeism (for 2018); and larger number of services with referrals from primary health care centers (for 2014). Expanding the view on orthodontics and including preventive, interceptive, and corrective treatments at different points in health care networks are essential strategies for achieving comprehensive care in universal health systems. PMAQ CEO, , CEO) 201 Brazil (CEO approach independently Mann U. U . U) h0 h (h0 h1. h1 (h1) variables chisquare chi square test. test test) 5 5% 13 resources degrees servants administration tender network records goals 2018) 2014. 2014) preventive interceptive systems 20 (h (h1 1 2

RESUMO: Hemoptise associada a sinais respiratórios são achados típicos de tromboembolismo da veia cava caudal (TVCC) em bovinos. Todavia, o TVCC pode estar acompanhado de um amplo espectro de sinais clínicos e lesões macroscópicas. Esse estudo tem por objetivo relatar a frequência do diagnóstico de TVCC em bovinos necropsiados no sul do Brasil e descrever os sinais clínicos, assim como achados patológicos dessa condição. De um total de 1.976 exames post-mortem realizados em bovinos no Sul do Brasil, 30 casos de TVCC foram diagnosticados (1,5%). No exame clínico, o principal curso clínico observado foi crônico (13/30), seguido do hiperagudo (7/30), agudo (4/30) e subagudo (5/30), em um caso o histórico clínico não foi fornecido. Hemoptise (17/30), dispneia (8/30) e anorexia ou hiporexia (7/30) foram os sinais clínicos mais comumente relatados. Tromboflebite séptica da veia cava caudal (24/30), abscessos hepáticos (24/30), hemorragia pulmonar (23/30) e pneumonia embólica (19/30) foram as principais lesões observadas na necropsia. Com esse trabalho conclui-se que TVCC é uma causa relevante de morte em bovinos no estado de Santa Catarina, principalmente em vacas leiteiras adultas. A doença é caracterizada por uma variedade de sinais clínicos e lesões, necessitando de atenção dos veterinários para o correto diagnóstico. Ainda, a associação entre o histórico clínico, sinais clínicos e lesões de necropsia é essencial para o diagnóstico de TVCC em bovinos. RESUMO (TVCC Todavia macroscópicas condição 1976 1 976 1.97 postmortem post mortem 3 1,5%. 15 1,5% . 5 (1,5%) 13/30, 1330 13/30 , 13 (13/30) 7/30, 730 7/30 7 4/30 430 4 (4/30 5/30, 530 5/30 (5/30) fornecido 17/30, 1730 17/30 17 (17/30) 8/30 830 8 (8/30 (7/30 relatados 24/30, 2430 24/30 24 (24/30) 23/30 2330 23 (23/30 19/30 1930 19 (19/30 concluise conclui se Catarina adultas Ainda 197 97 1.9 1,5 (1,5% 133 13/3 (13/30 73 7/3 4/3 43 (4/3 53 5/3 (5/30 173 17/3 (17/30 8/3 83 (8/3 (7/3 243 24/3 2 (24/30 23/3 233 (23/3 19/3 193 (19/3 9 1. 1, (1,5 13/ (13/3 7/ 4/ (4/ 5/ (5/3 17/ (17/3 8/ (8/ (7/ 24/ (24/3 23/ (23/ 19/ (19/ (1, (13/ (4 (5/ (17/ (8 (7 (24/ (23 (19 (1 (13 ( (5 (17 (24 (2

ABSTRACT: Hemoptysis associated with respiratory disorders are some findings of caudal vena cava thrombosis (CVCT) in cattle. Nevertheless, CVCT may be accompanied by a broad spectrum of clinical signs and gross lesions. This study reported the frequency of CVCT in cattle necropsied in Southern Brazil and described its clinical signs, as well as pathological findings. From a total of 1,976 postmortem examination reports in cattle in Southern Brazil, there were 30 cases (1.5%) of CVCT. In the clinical evaluation, the main clinical course was chronic (13/30), followed by peracute (7/30), acute (4/30), and subacute (5/30). Hemoptysis (17/30), dyspnea (8/30), and anorexia or hyporexia (7/30) were the most reported clinical signs. Septic thrombophlebitis of the caudal vena cava (24/30), hepatic abscesses (24/30), pulmonary hemorrhage (23/30), and embolic pneumonia (19/30) were the main lesions observed at the necropsy. We concluded that CVCT is a relevant cause of death in bovines from Santa Catarina state, mainly in adult dairy cows. The disease is characterized by a wide range of clinical signs and lesions, requiring attention from veterinarians for the correct diagnosis. Furthermore, the association between the clinical history, clinical signs, and lesions is essential for the diagnosis of CVCT in cattle. ABSTRACT (CVCT Nevertheless 1976 1 976 1,97 3 1.5% 15 5 (1.5% evaluation 13/30, 1330 13/30 , 13 (13/30) 7/30, 730 7/30 7 4/30, 430 4/30 4 (4/30) 5/30. 530 5/30 . (5/30) 17/30, 1730 17/30 17 (17/30) 8/30, 830 8/30 8 (8/30) (7/30 24/30, 2430 24/30 24 (24/30) 23/30, 2330 23/30 23 (23/30) 19/30 1930 19 (19/30 necropsy state cows Furthermore history 197 97 1,9 1.5 (1.5 133 13/3 (13/30 73 7/3 43 4/3 (4/30 53 5/3 (5/30 173 17/3 (17/30 83 8/3 (8/30 (7/3 243 24/3 2 (24/30 233 23/3 (23/30 19/3 193 (19/3 9 1, 1. (1. 13/ (13/3 7/ 4/ (4/3 5/ (5/3 17/ (17/3 8/ (8/3 (7/ 24/ (24/3 23/ (23/3 19/ (19/ (1 (13/ (4/ (5/ (17/ (8/ (7 (24/ (23/ (19 ( (13 (4 (5 (17 (8 (24 (23 (2

ABSTRACT Objective: To calculate the rate of tuberculosis recurrence, estimate its average time until recurrence, and identify factors associated with recurrence in Brazil. Methods: Retrospective cohort study with a linked database from the Notifiable Diseases Information System. The study included individuals diagnosed with tuberculosis in 2015, focusing on those who experienced their first recurrence within 6.5 years. We estimated the relative risk (RR) and its 95% confidence interval (95%CI), as well as the population attributable fraction (PAF) or the population preventable fraction (PPF) of associated factors. Results: Within a 6.5-year period, 3,253 individuals (6.5%) experienced tuberculosis recurrence, with a median time of 2.2 years. Positively associated factors included: male sex (RR: 1.4; 95%CI 1.3–1.5; PAF: 22.9%), age 30 to 59 years (RR: 3.0; 95%CI 1.6–5.7; PAF: 36.0%), black race (RR: 1.3; 95%CI 1.2–1.5; PAF: 3.5%), mixed race (RR: 1.3; 95%CI 1.2–1.4; PAF: 10.6%), deprivation of liberty (RR: 1.9; 95%CI 1.7–2.1; PAF: 9.1%), pulmonary/mixed clinical form (RR: 1.7; 95%CI 1.4–1.9; PAF: 37.1%), acquired immunodeficiency syndrome diagnosis (RR: 1.8; 95%CI 1.5–1.9; PAF: 4.3%), and alcohol use (RR: 1.2; 95%CI 1.1–1.3; PAF: 2.9%). Negatively associated factors were: 12 or more years of schooling (RR: 0.5; 95%CI 0.4–0.6; PPF: 3.3%) and supervised treatment (RR: 0.9; 95%CI 0.8–0.9; PPF: 4.4%). Conclusion: This study revealed high tuberculosis recurrence rates in Brazil, influenced by sociodemographic, compartmental, and social factors, both positively and negatively impacting disease recurrence.

RESUMO Objetivo: Calcular a taxa de recorrência de tuberculose, estimar seu tempo médio e identificar seus fatores associados no Brasil. Métodos: Estudo de coorte retrospectiva com dados de linkage do Sistema de Informação de Agravos de Notificação. Incluímos pessoas diagnosticadas com tuberculose em 2015, com foco naquelas que tiveram sua primeira recorrência em 6,5 anos. Estimamos o risco relativo (RR) e seus intervalos de confiança de 95% (IC95%), assim como a fração atribuível populacional (FAP) ou a fração prevenível populacional (FPP) dos fatores associados. Resultados: No período de 6,5 anos, 3.253 indivíduos (6,5%) tiveram recorrência de tuberculose, com tempo médio de 2,2 anos. Fatores positivamente associados incluíram: sexo masculino (RR: 1,4; IC95% 1,3–1,5; FAP: 22,9%), idade de 30 a 59 anos (RR: 3,0; IC95% 1,6–5,7; FAP: 36,0%), raça/cor preta (RR: 1,3; IC95% 1,2–1,5; FAP: 3,5%) ou raça/cor parda (RR: 1,3; IC95% 1,2–1,4; FAP: 10,6%), privação de liberdade (RR: 1,9; IC95% 1,7–2,1; FAP: 9,1%), forma clínica pulmonar/mista (RR: 1,7; IC95% 1,4–1,9; FAP: 37,1%), diagnóstico de síndrome da imunodeficiência adquirida (RR: 1,8; IC95% 1,5–1,9; FAP: 4,3%) e uso de álcool (RR: 1,2; IC95% 1,1–1,3; FAP: 2,9%). Fatores negativamente associados foram: 12 ou mais anos de estudo (RR: 0,5; IC95% 0,4–0,6; FPP: 3,3%) e tratamento supervisionado (RR: 0,9; IC95% 0,8–0,9; FPP: 4,4%). Conclusão: Revelamos taxas elevadas de recorrência de tuberculose no Brasil, com fatores sociodemográficos, comportamentais e sociais influenciando na recorrência da doença.

Abstract The aim of this study was to investigate the association between maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder (ASD). We conducted a case-control study with children and adolescents diagnosed with ASD and neurotypical individuals. The data were collected using a semi-structured questionnaire administered during interviews with the children’s mothers or guardians. The following variables were analyzed: child sex and age; maternal and parental age; use of medicines before and during pregnancy; classes of medicines used during pregnancy; maternal and paternal smoking; maternal and paternal drinking; maternal and paternal illicit drug use. The data were analyzed using logistic regression and crude and adjusted odds ratios (OR). After adjustment, the results showed an association between maternal use of antipyretics/pain killers during pregnancy (OR = 2.26; 95%CI 1.29-3.95; p < 0.040) and ASD. No association was found between maternal and paternal smoking, drinking and illicit drug use before and during pregnancy and ASD. The findings suggest that the development of ASD is influenced by environmental factors.

Resumo O presente estudo objetivou investigar a associação entre o TEA e o uso materno e paterno de medicamentos, tabaco, álcool e drogas ilícitas. Trata-se de um estudo caso-controle realizado com crianças e adolescentes diagnosticados com TEA e indivíduos neurotípicos. Os dados foram colhidos por meio de entrevista com as mães ou responsáveis. Foram analisadas as variáveis sexo e idade das crianças/adolescentes; idade dos pais; uso de medicamentos antes e durante a gestação; classes de medicamentos usados na gestação; tabagismo materno e paterno; etilismo materno e paterno; uso de drogas ilícitas pelos pais. Para a análise das informações, utilizou-se o modelo de regressão logística, além da razão de chances (OR) bruta e ajustada. Os resultados mostraram que, após os ajustes, foi encontrada associação entre o uso materno na gestação de antitérmicos/analgésicos (OR = 2,26; IC95% 1,29-3,95; p < 0,040) com o TEA. Já o uso de tabaco, álcool e drogas ilícitas materno e paterno, antes e durante a gestação, não apontou relação com o TEA. Os dados encontrados sugerem que existe influência de fatores ambientais no desenvolvimento do TEA.

Resumo O presente estudo objetivou investigar a associação entre o TEA e o uso materno e paterno de medicamentos, tabaco, álcool e drogas ilícitas. Trata-se de um estudo caso-controle realizado com crianças e adolescentes diagnosticados com TEA e indivíduos neurotípicos. Os dados foram colhidos por meio de entrevista com as mães ou responsáveis. Foram analisadas as variáveis sexo e idade das crianças/adolescentes; idade dos pais; uso de medicamentos antes e durante a gestação; classes de medicamentos usados na gestação; tabagismo materno e paterno; etilismo materno e paterno; uso de drogas ilícitas pelos pais. Para a análise das informações, utilizou-se o modelo de regressão logística, além da razão de chances (OR) bruta e ajustada. Os resultados mostraram que, após os ajustes, foi encontrada associação entre o uso materno na gestação de antitérmicos/analgésicos (OR = 2,26; IC95% 1,29-3,95; p < 0,040) com o TEA. Já o uso de tabaco, álcool e drogas ilícitas materno e paterno, antes e durante a gestação, não apontou relação com o TEA. Os dados encontrados sugerem que existe influência de fatores ambientais no desenvolvimento do TEA. tabaco Tratase Trata se casocontrole caso controle neurotípicos responsáveis crianças/adolescentes criançasadolescentes pais informações utilizouse utilizou logística OR ajustada ajustes antitérmicosanalgésicos antitérmicos analgésicos 2,26 226 2 26 IC95 IC 1,293,95 129395 1,29 3,95 1 29 3 95 1,29-3,95 0,040 0040 0 040 2,2 22 IC9 293 1,293,9 12939 129 1,2 395 3,9 9 1,29-3,9 0,04 004 04 2, 1,293, 1293 12 1, 39 3, 1,29-3, 0,0 00 1,293 1,29-3 0, 1,29-

Abstract The aim of this study was to investigate the association between maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder (ASD). We conducted a case-control study with children and adolescents diagnosed with ASD and neurotypical individuals. The data were collected using a semi-structured questionnaire administered during interviews with the children’s mothers or guardians. The following variables were analyzed: child sex and age; maternal and parental age; use of medicines before and during pregnancy; classes of medicines used during pregnancy; maternal and paternal smoking; maternal and paternal drinking; maternal and paternal illicit drug use. The data were analyzed using logistic regression and crude and adjusted odds ratios (OR). After adjustment, the results showed an association between maternal use of antipyretics/pain killers during pregnancy (OR = 2.26; 95%CI 1.29-3.95; p < 0.040) and ASD. No association was found between maternal and paternal smoking, drinking and illicit drug use before and during pregnancy and ASD. The findings suggest that the development of ASD is influenced by environmental factors. . (ASD) casecontrol case control individuals semistructured semi structured childrens s guardians age OR. OR (OR) adjustment antipyreticspain antipyretics pain 2.26 226 2 26 95CI CI 95 1.293.95 129395 1.29 3.95 1 29 3 1.29-3.95 0.040 0040 0 040 factors (ASD 2.2 22 9 293 1.293.9 12939 129 1.2 395 3.9 1.29-3.9 0.04 004 04 2. 1.293. 1293 12 1. 39 3. 1.29-3. 0.0 00 1.293 1.29-3 0. 1.29-

RESUMO: A alta dependência da agricultura por fertilizantes demanda um aprimoramento nos processos envolvidos, tendo como propósito a sustentabilidade ambiental e econômica. Objetivou-se comparar o desempenho de mecanismos dosadores helicoidais, com duas formulações de fertilizantes granulados em três velocidades operacionais. Na realização do experimento, utilizou-se bancada eletrônica e automatizada, com a qual se avaliou o desempenho dos mecanismos dosadores helicoidal simples e helicoidal duplo por transbordo, em um delineamento inteiramente casualizado, com duas formulações de fertilizantes NPK granulados (04-14-08 e 04-30-10), em razão de diferentes velocidades angulares (1.11, 1.94, e 2.77 m s-1). Durante os testes, coletaram-se dados de vazão que foram submetidos à estatística descritiva, histogramas de frequência e ao controle estatístico de processo. O dosador helicoidal simples, conforme o aumento da velocidade, exibiu maior homogeneidade de deposição de fertilizante granulado, com 611 falhas ha-1 em relação a 3.763 falhas ha-1 do helicoidal duplo. Apesar de que as velocidades de 7,0 e 10,0 km h-1 geraram um aumento da vazão de ambos os fertilizantes granulados, conforme esperado, o fertilizante 04-30-10 obteve a distribuição mais uniforme na menor velocidade. RESUMO envolvidos econômica Objetivouse Objetivou helicoidais operacionais experimento utilizouse utilizou automatizada transbordo casualizado 041408 04 14 08 (04-14-0 043010, 043010 30 10 , 04-30-10) 1.11, 111 1 11 (1.11 194 94 1.94 277 2 77 2.7 s1. s1 s . s-1) testes coletaramse coletaram descritiva processo velocidade granulado 61 ha1 ha ha- 3763 3 763 3.76 70 7 0 7, 100 10, h1 h h- esperado 04-30-1 04140 (04-14- 04301 1.11 (1.1 19 9 1.9 27 2. s-1 6 376 76 3.7 04-30- 0414 (04-14 0430 1.1 (1. 1. s- 37 3. 04-30 041 (04-1 043 (1 04-3 (04- ( 04- (04 (0

ABSTRACT: The high dependence of agriculture on fertilizers demands an improvement in the processes involved, with the purpose of environmental and economic sustainability. The objective was to compare the performance of helical dosing mechanisms with two formulations of granulated NPK fertilizers at three operating speeds. During the experiment, we used an electronic and automated bench to evaluate the performance of the single helical and double helical dosing mechanisms, in a completely randomized design. This bench measured the overflow of the two formulations of granulated NPK fertilizers (04-14-08 and 04-30-10) under different angular velocities (1.11; 1.94; and 2.77 m s-1). On the tests, we collected flow data and submitted them to descriptive statistics, frequency histograms, and statistical process control. The single helical feeder, as the speed increased, exhibited greater homogeneity of granulated NPK fertilizer deposition, with 611 flaws ha-1 compared to 3763 flaws ha-1 in the double screw. Although, the speeds of 7.0 and 10.0 km h-1 generated an increase in the flow of both granular fertilizers, as expected, the 04-30-10 fertilizer obtained the most uniform distribution at the lowest speed. ABSTRACT involved sustainability experiment design 041408 04 14 08 (04-14-0 043010 30 10 1.11 111 1 11 (1.11 1.94 194 94 277 2 77 2.7 s1. s1 s . s-1) tests statistics histograms control feeder increased deposition 61 ha1 ha ha- 376 screw Although 70 7 0 7. 100 10. h1 h h- expected 04-30-1 04140 (04-14- 04301 3 1.1 (1.1 1.9 19 9 27 2. s-1 6 37 04-30- 0414 (04-14 0430 1. (1. s- 04-30 041 (04-1 043 (1 04-3 (04- ( 04- (04 (0

RESUMO O objetivo deste estudo foi avaliar a inclusão de níveis crescentes de torta de crambe, sobre a digestibilidade in vitro da matéria seca (DIVMS), matéria orgânica (DIVMO) e proteína bruta, cinética da produção cumulativa de gás e parâmetros de fermentação. Foram avaliadas as inclusões de 0; 50; 100; 150 g / kg de MS em dietas. Houve efeito quadrático das proporções de torta de crambe nos suplementos concentrados para DIVMS e DIVMO (ponto máximo em 0,25 e 0,91 g Kg-1 DM, respectivamente). A produção total de gás (A + D) foi influenciada por a presença de torta de crambe com efeito quadrático tendo como ponto mínimo em 0,02 g kg-1 DM. Houve um efeito quadrático do pH e NH3-N nos tempos de coleta em todas as dietas, os menores valores de pH foram observados entre 4,8 a 8,7 e os picos de produção de NH3-N entre 4,8 e 6,3 horas após o início da incubação. Conclui-se que a substituição do farelo de soja por crambe triturado até 150 g kg-1 em suplementos concentrados para ruminantes não prejudica a cinética de degradação ruminal. DIVMS, , (DIVMS) (DIVMO bruta fermentação 0 50 100 15 dietas 025 25 0,2 091 91 0,9 Kg1 Kg 1 Kg- DM respectivamente. respectivamente . respectivamente) D 002 02 0,0 kg1 kg- NH3N NHN NH3 N NH 48 4 8 4, 87 7 8, 63 6 3 6, incubação Concluise Conclui se ruminal (DIVMS 5 10 2 0, 09 9 00

ABSTRACT Aimed with this study was evaluate the increasing levels of crambe crushed, on in vitro digestibility of dry matter (IVDDM), organic matter (IVDOM) and crude protein (IVDCP), parameters of fermentation and kinetics of the cumulative gas production. The crushed crambe were included in the diets at 0; 50; 100; 150 g/kg of DM. There was a quadratic effect of the proportions of crambe crushed in the concentrated supplements on IVDDM and IVDOM (maximum point at 0.25 and 0.91 g Kg-1 DM, respectively). Total gas production (A + D) was influenced by the presence of crambe crushed with quadratic effect on minimal point on 0.02 g Kg-1 DM. There was a quadratic effect for pH in the collection times in all diets, the lowest pH values were observed between 4.8 to 8.7 hours. There was a quadratic effect for ammoniacal nitrogen in the collection times in all diets with peaks of NH3-N production occurred between 4.8 and 6.3 hours after the beginning of the incubation. Concluded that the inclusion of crambe crushed up to 150 g kg-1 DM in diets for ruminants does not impair the ruminal degradation kinetics. IVDDM, , (IVDDM) (IVDOM IVDCP, IVDCP (IVDCP) 0 50 100 15 gkg kg maximum 025 25 0.2 091 91 0.9 Kg1 Kg 1 Kg- respectively. respectively . respectively) A D 002 02 0.0 48 4 8 4. 87 7 8. NH3N NHN NH3 N NH 63 6 3 6. incubation kg1 kg- (IVDDM (IVDCP 5 10 2 0. 09 9 00

RESUMO Objetivo: Calcular a taxa de recorrência de tuberculose, estimar seu tempo médio e identificar seus fatores associados no Brasil. Métodos: Estudo de coorte retrospectiva com dados de linkage do Sistema de Informação de Agravos de Notificação. Incluímos pessoas diagnosticadas com tuberculose em 2015, com foco naquelas que tiveram sua primeira recorrência em 6,5 anos. Estimamos o risco relativo (RR) e seus intervalos de confiança de 95% (IC95%), assim como a fração atribuível populacional (FAP) ou a fração prevenível populacional (FPP) dos fatores associados. Resultados: No período de 6,5 anos, 3.253 indivíduos (6,5%) tiveram recorrência de tuberculose, com tempo médio de 2,2 anos. Fatores positivamente associados incluíram: sexo masculino (RR: 1,4; IC95% 1,3–1,5; FAP: 22,9%), idade de 30 a 59 anos (RR: 3,0; IC95% 1,6–5,7; FAP: 36,0%), raça/cor preta (RR: 1,3; IC95% 1,2–1,5; FAP: 3,5%) ou raça/cor parda (RR: 1,3; IC95% 1,2–1,4; FAP: 10,6%), privação de liberdade (RR: 1,9; IC95% 1,7–2,1; FAP: 9,1%), forma clínica pulmonar/mista (RR: 1,7; IC95% 1,4–1,9; FAP: 37,1%), diagnóstico de síndrome da imunodeficiência adquirida (RR: 1,8; IC95% 1,5–1,9; FAP: 4,3%) e uso de álcool (RR: 1,2; IC95% 1,1–1,3; FAP: 2,9%). Fatores negativamente associados foram: 12 ou mais anos de estudo (RR: 0,5; IC95% 0,4–0,6; FPP: 3,3%) e tratamento supervisionado (RR: 0,9; IC95% 0,8–0,9; FPP: 4,4%). Conclusão: Revelamos taxas elevadas de recorrência de tuberculose no Brasil, com fatores sociodemográficos, comportamentais e sociais influenciando na recorrência da doença. Objetivo Brasil Métodos Notificação 2015 65 6 5 6, RR (RR 95 IC95%, IC95 IC , (IC95%) FAP (FAP FPP (FPP Resultados 3253 3 253 3.25 6,5% (6,5% 22 2 2, incluíram 1,4 14 1 4 1,3–1,5 1315 22,9%, 229 22,9% 9 22,9%) 3,0 0 1,6–5,7 1657 7 36,0%, 360 36,0% 36 36,0%) raçacor raça cor 1,3 13 1,2–1,5 1215 3,5% 35 1,2–1,4 1214 10,6%, 106 10,6% 10 10,6%) 1,9 19 1,7–2,1 1721 9,1%, 91 9,1% 9,1%) pulmonarmista pulmonar mista 1,7 17 1,4–1,9 1419 37,1%, 371 37,1% 37 37,1%) 1,8 18 8 1,5–1,9 1519 4,3% 43 1,2 1,1–1,3 1113 2,9%. 29 2,9% . 2,9%) foram 0,5 05 0,4–0,6 0406 3,3% 33 0,9 09 0,8–0,9 0809 4,4%. 44 4,4% 4,4%) Conclusão sociodemográficos doença 201 IC9 (IC95% 325 25 3.2 (6,5 1, 1,3–1, 131 22,9 3, 1,6–5, 165 36,0 1,2–1, 121 3,5 10,6 1,7–2, 172 9,1 1,4–1, 141 37,1 1,5–1, 151 4,3 1,1–1, 111 2,9 0, 0,4–0, 040 3,3 0,8–0, 080 4,4 20 (IC95 32 3. (6, 1,3–1 22, 1,6–5 16 36, 1,2–1 10, 1,7–2 9, 1,4–1 37, 1,5–1 15 4, 1,1–1 11 0,4–0 04 0,8–0 08 (IC9 (6 1,3– 1,6– 1,2– 1,7– 1,4– 1,5– 1,1– 0,4– 0,8– (IC ( 1,6 1,5 1,1 0,4 0,8

ABSTRACT Objective: To calculate the rate of tuberculosis recurrence, estimate its average time until recurrence, and identify factors associated with recurrence in Brazil. Methods: Retrospective cohort study with a linked database from the Notifiable Diseases Information System. The study included individuals diagnosed with tuberculosis in 2015, focusing on those who experienced their first recurrence within 6.5 years. We estimated the relative risk (RR) and its 95% confidence interval (95%CI), as well as the population attributable fraction (PAF) or the population preventable fraction (PPF) of associated factors. Results: Within a 6.5-year period, 3,253 individuals (6.5%) experienced tuberculosis recurrence, with a median time of 2.2 years. Positively associated factors included: male sex (RR: 1.4; 95%CI 1.3–1.5; PAF: 22.9%), age 30 to 59 years (RR: 3.0; 95%CI 1.6–5.7; PAF: 36.0%), black race (RR: 1.3; 95%CI 1.2–1.5; PAF: 3.5%), mixed race (RR: 1.3; 95%CI 1.2–1.4; PAF: 10.6%), deprivation of liberty (RR: 1.9; 95%CI 1.7–2.1; PAF: 9.1%), pulmonary/mixed clinical form (RR: 1.7; 95%CI 1.4–1.9; PAF: 37.1%), acquired immunodeficiency syndrome diagnosis (RR: 1.8; 95%CI 1.5–1.9; PAF: 4.3%), and alcohol use (RR: 1.2; 95%CI 1.1–1.3; PAF: 2.9%). Negatively associated factors were: 12 or more years of schooling (RR: 0.5; 95%CI 0.4–0.6; PPF: 3.3%) and supervised treatment (RR: 0.9; 95%CI 0.8–0.9; PPF: 4.4%). Conclusion: This study revealed high tuberculosis recurrence rates in Brazil, influenced by sociodemographic, compartmental, and social factors, both positively and negatively impacting disease recurrence. Objective Brazil Methods System 2015 65 6 5 6. RR (RR 95 95%CI, 95CI CI , (95%CI) PAF (PAF PPF (PPF Results 6.5year 65year year period 3253 3 253 3,25 6.5% (6.5% 22 2 2. 1.4 14 1 4 1.3–1.5 1315 22.9%, 229 22.9% 9 22.9%) 3.0 0 1.6–5.7 1657 7 36.0%, 360 36.0% 36 36.0%) 1.3 13 1.2–1.5 1215 3.5%, 35 3.5% 3.5%) 1.2–1.4 1214 10.6%, 106 10.6% 10 10.6%) 1.9 19 1.7–2.1 1721 9.1%, 91 9.1% 9.1%) pulmonarymixed pulmonary 1.7 17 1.4–1.9 1419 37.1%, 371 37.1% 37 37.1%) 1.8 18 8 1.5–1.9 1519 4.3%, 43 4.3% 4.3%) 1.2 1.1–1.3 1113 2.9%. 29 2.9% . 2.9%) were 0.5 05 0.4–0.6 0406 3.3% 33 0.9 09 0.8–0.9 0809 4.4%. 44 4.4% 4.4%) Conclusion sociodemographic compartmental 201 (95%CI 5year 325 25 3,2 (6.5 1. 1.3–1. 131 22.9 3. 1.6–5. 165 36.0 1.2–1. 121 3.5 10.6 1.7–2. 172 9.1 1.4–1. 141 37.1 1.5–1. 151 4.3 1.1–1. 111 2.9 0. 0.4–0. 040 3.3 0.8–0. 080 4.4 20 32 3, (6. 1.3–1 22. 1.6–5 16 36. 1.2–1 10. 1.7–2 9. 1.4–1 37. 1.5–1 15 4. 1.1–1 11 0.4–0 04 0.8–0 08 (6 1.3– 1.6– 1.2– 1.7– 1.4– 1.5– 1.1– 0.4– 0.8– ( 1.6 1.5 1.1 0.4 0.8

Abstract Thiosemicarbazones are promising classes of compounds with antitumor activity. For this study, six 2,4-dihydroxy-benzylidene-thiosemicarbazones compounds were synthesized. These compounds were submitted to different assays in silico, in vitro and in vivo to evaluate the toxicological, antioxidant and antitumor effects. The in silico results were evaluated by the SwissADME and pkCSM platforms and showed that all compounds had good oral bioavailability profiles. The in vitro and in vivo toxicity assays showed that the compounds showed low cytotoxicity against different normal cells and did not promote hemolytic effects. The single dose acute toxicity test (2000 mg/kg) showed that none of the compounds were toxic to mice. In in vitro antioxidant activity assays, the compounds showed moderate to low activity, with PB17 standing out for the ABTS radical capture assay. The in vivo antioxidant activity highlighted the compounds 1, 6 and 8 that promoted a significant increase in the concentration of liver antioxidant enzymes. Finally, all compounds showed promising antitumor activity against different cell lines, especially MCF-7 and DU145 lines, in addition, they inhibited the growth of sarcoma 180 at concentrations lower than 50 mg/kg. These results showed that the evaluated compounds can be considered as potential antitumor agents. study 2,4dihydroxybenzylidenethiosemicarbazones 24dihydroxybenzylidenethiosemicarbazones dihydroxybenzylidenethiosemicarbazones 2,4 dihydroxy benzylidene thiosemicarbazones 2 4 synthesized toxicological effects profiles 2000 (200 mg/kg mgkg mg kg mice PB PB1 assay 1 enzymes Finally lines MCF7 MCF 7 MCF- DU DU14 addition 18 5 agents 4dihydroxybenzylidenethiosemicarbazones 24 2, 200 (20 DU1 20 (2 (

RESUMO Para práticas de gestão e tomada de decisões eficazes, as incertezas associadas aos modelos climáticos regionais (MCR) e aos seus cenários precisam ser avaliadas no contexto das alterações climáticas. Este estudo analisa tendências de longo prazo em conjuntos de dados de precipitação e temperatura (valores máximos e mínimos) oriundos da NASA, da Earth Exchange Global Daily Downscaled Prediction (NEX-GDDP), por meio do Caminho de Concentração Representativa (RCP 4.5 e 8.5), na Bacia do Rio São Francisco utilizando o método REA (Reliable Ensemble Average). Em cada grade, o multimodelo construído foi corrigido para períodos anuais, secos, chuvosos e pré-estação – para períodos históricos (1961-2005) e futuros (2006-2100), usando o software CMhyd. Para detectar tendências de precipitação e temperatura mínima e máxima na bacia, foram utilizados quatro diferentes métodos juntamente com o conjunto de dados que originou o multimodelo. Os quatro métodos utilizados foram: Mann-Kendall, teste de pré-clareamento de Mann-Kendall, pré-clareamento com correção de viés e correlação de Spearman. Na análise das métricas de precipitação e temperatura, os resultados do NRMSD mostraram que, de forma geral, o modelo CSIRO apresentou resultados mais satisfatórios em todas as regiões fisiográficas. O coeficiente de correlação de Person mostrou melhor ajuste da precipitação para os modelos MIROC5, EC.EARTH e NORESMI1, nas áreas do submédio e alto São Francisco. Para a temperatura mínima, os modelos CSIRO e NORESMI1 apresentaram o melhor ajuste, em geral. Na temperatura máxima, os modelos EC.EARTH e CSIRO apresentaram resultados mais satisfatórios. No que diz respeito à análise de tendência, os resultados indicaram uma tendência crescente na temperatura média anual e na precipitação em toda a bacia. Quando analisados por sub-região, os resultados mostram uma tendência crescente nas temperaturas médias mínimas e máximas mensais no médio e baixo SFRB, enquanto a precipitação média mensal aumenta durante a estação chuvosa e pré-estação no Alto São Francisco. Os resultados desta pesquisa poderão ser utilizados por entidades governamentais, como a Defesa Civil, para subsidiar tomadas de decisões que exijam ações/medidas de realocação de pessoas/comunidades para locais de menor risco para minimizar situações de risco ou vulnerabilidade para a população que vive nas proximidades do rio. eficazes MCR (MCR climáticas valores mínimos NASA NEXGDDP, NEXGDDP NEX GDDP , (NEX-GDDP) RCP 45 4 5 4. 8.5, 85 8.5 8 8.5) Reliable Average. Average . Average) grade anuais secos préestação pré 19612005 1961 2005 (1961-2005 20062100, 20062100 2006 2100 (2006-2100) CMhyd bacia MannKendall, MannKendall Mann Kendall, Kendall Mann-Kendall préclareamento clareamento Spearman geral fisiográficas MIROC5 MIROC ECEARTH EC EARTH NORESMI subregião, subregião sub região, região sub-região SFRB governamentais Civil açõesmedidas ações medidas pessoascomunidades pessoas comunidades rio (NEX-GDDP 8. 1961200 196 200 (1961-200 2006210 210 (2006-2100 196120 19 20 (1961-20 200621 21 (2006-210 19612 1 2 (1961-2 20062 (2006-21 (1961- (2006-2 (1961 (2006- (196 (2006 (19 (200 (1 (20 ( (2

ABSTRACT For effective management practices and decision-making, the uncertainties associated with regional climate models (RCMs) and their scenarios need to be assessed in the context of climate change. This study analyzes long-term trends in precipitation and temperature data sets (maximum and minimum values) from the NASA, Earth Exchange Global Daily Downscaled Prediction (NEX-GDDP), under the São Francisco River Basin Representative Concentration Path (RCP) 4.5 and 8.5, using the REA (Reliable Ensemble Average) method. In each grid, the built multi-model was bias-corrected using the CMhyd software for annual, dry, wet, and pre-season periods – for historical (1961-2005) and future (2006-2100) periods. The multi-model and four different methods, namely: The Mann-Kendall, Mann-Kendall pre-brightening test, bias-corrected pre-brightening, and Spearman correlation, were used to detect trends in precipitation, and minimum and maximum temperature. In the analysis of precipitation and temperature metrics, the results for the NRMSD showed that, in general, the CSIRO model presented more satisfactory results in all physiographic regions. Person's correlation coefficient showed a better adjustment of precipitation for the MIROC5, EC.EARTH and NORESMI1 models, in areas of sub-medium and upper São Francisco. For the minimum temperature, the CSIRO and NORESMI1 models showed the best fit, in general. At maximum temperature, the EC.EARTH and CSIRO models showed more satisfactory results. With regard to trend analysis, the results indicated an increasing trend in mean annual temperature and precipitation across the basin. When analyzed by subregion, the results show an increasing trend in monthly average minimum and maximum temperatures in the middle and lower SFRB, while average monthly rainfall increases during the rainy season and preseason in Upper São Francisco. The results of this research can be used by government entities, such as Civil Defense, to subsidize decision-making that requires actions/measures to relocate people/communities to less risky locations to minimize risk or vulnerability situations for the population living nearby to the river. decisionmaking, decisionmaking decision making, making RCMs (RCMs change longterm long term values NASA NEXGDDP, NEXGDDP NEX GDDP , (NEX-GDDP) RCP (RCP 45 4 5 4. 85 8 8.5 Reliable Average method grid multimodel multi biascorrected bias corrected dry wet pre 19612005 1961 2005 (1961-2005 20062100 2006 2100 (2006-2100 methods namely MannKendall, MannKendall Mann Kendall, Kendall prebrightening brightening test prebrightening, brightening, metrics general regions Persons Person s MIROC5 MIROC ECEARTH EC EARTH NORESMI submedium sub medium fit basin subregion SFRB entities Defense actionsmeasures actions measures peoplecommunities people communities river (NEX-GDDP 8. 1961200 196 200 (1961-200 2006210 210 (2006-210 196120 19 20 (1961-20 200621 21 (2006-21 19612 1 2 (1961-2 20062 (2006-2 (1961- (2006- (1961 (2006 (196 (200 (19 (20 (1 (2 (

Abstract The disease coronavirus COVID-19 has been the cause of millions of deaths worldwide. Among the proteins of SARS-CoV-2, non-structural protein 12 (NSP12) plays a key role during COVID infection and is part of the RNA-dependent RNA polymerase complex. The monitoring of NSP12 polymorphisms is extremely important for the design of new antiviral drugs and monitoring of viral evolution. This study analyzed the NSP12 mutations detected in circulating SARS-CoV-2 during the years 2020 to 2022 in the population of the city of Manaus, Amazonas, Brazil. The most frequent mutations found were P323L and G671S. Reports in the literature indicate that these mutations are related to transmissibility efficiency, which may have contributed to the extremely high numbers of cases in this location. In addition, two mutations described here (E796D and R914K) are close and have RMSD that is similar to the mutations M794V and N911K, which have been described in the literature as influential on the performance of the NSP12 enzyme. These data demonstrate the need to monitor the emergence of new mutations in NSP12 in order to better understand their consequences for the treatments currently used and in the design of new drugs. COVID19 19 COVID-1 worldwide SARSCoV2, SARSCoV2 SARSCoV SARS CoV 2, 2 nonstructural non structural 1 NSP (NSP12 RNAdependent dependent complex NSP1 evolution SARS-CoV- 202 Manaus Amazonas Brazil PL P L G671S GS G S efficiency location addition E796D ED E D R914K RK R K MV M V N911K NK N enzyme COVID1 COVID- (NSP1 SARS-CoV 20 (NSP

Abstract Background It is justified by the high population’s morbidity and mortality rate, as well as the increasing present use of nanoparticles in this pathological context. Objectives To describe the main nanotechnology breakthroughs in the field of cardiovascular disease (CVD) and disseminate pertinent information in the literature. Methods This is a systematic review conducted between September and October 2021. The review was carried out through basic nature, following the initial script for the selective reading of articles in chronological order to collect relevant and consistent data related to the theme. Results It is evidenced the main advances of nanotechnology in the field of CVDs, namely, acute coronary syndromes (ACSs), heart failure (HF), and systemic arterial hypertension (SAH). Conclusion The importance of further and deeper studies in this area is emphasized, in order to make the already approved treatments feasible, so they can reach all publics at a low cost. populations population s rate context CVD (CVD literature 2021 nature theme CVDs namely ACSs, ACSs , (ACSs) HF, HF (HF) SAH. SAH . (SAH) emphasized feasible cost 202 (ACSs (HF (SAH 20 2

ABSTRACT Widespread use of soluble mineral fertilizers derived from non-renewable sources has raised concerns about environmental impacts, energy expenditures, and sustainability. Combining biosolid and mineral sources of phosphorus and potassium to produce organomineral fertilizers (OMF) can be used as an alternative nutrient source while reducing the environmental impact of sewage residues. As this approach simultaneously provides nutrients and incorporates organic matter, we hypothesized the presence of an organic source (biosolid) granulated with mineral sources of potassium (K) and phosphorus (P) would reduce leaching due to the benefits of the organic source and the slower release caused by granulation. Our goal was to evaluate the effect of different OMFs on the leaching losses of nutrients. Two forms of isolated N, P, and K sources (granulated and non-granulated), five OMFs with different NPK proportions (1-2-0, 1-4-0, 1-0-2, 1-2-2, 1-2-4), and a control (unfertilized) were evaluated over ten weeks in a leaching column experiment. Non-granulated potassium sulfate exhibited the highest K leaching and did not differ from OMFs with K in their formulation (granulated PS, 1-0-2, 1-2-2, and 1-4-2). Planned contrasts showed that granulation was particularly effective at reducing K leaching, resulting in a 70 % reduction compared to non-granulated PS. While formulation and granulation showed a trend of potential benefits in reducing N-(NO3- + NO2-) leaching, the effect was not statistically significant. Interaction between fertilizer treatments and leaching events was marginally significant for NH4+ leaching, indicating temporal variations of OMFs in nutrient dynamics may be influenced by mineralization. As granulation modulated how OMFs affected nutrient leaching dynamics, this highlights the importance of the physical characteristics of fertilizers for effective nutrient management. nonrenewable non renewable impacts expenditures sustainability OMF (OMF residues matter (biosolid (K P (P N nongranulated, nongranulated , non-granulated) 120, 120 1 2 0, 0 (1-2-0 140, 140 4 1-4-0 102, 102 2, 1-0-2 122, 122 1-2-2 124, 124 1-2-4) unfertilized (unfertilized experiment Nongranulated Non PS 142. 142 . 1-4-2) 7 NNO3 NNO NO3 NO N-(NO3 NO2 NO2- NH4 NH mineralization management 12 (1-2- 14 1-4- 10 1-0- 1-2- 1-2-4 1-4-2 N-(NO (1-2 1-4 1-0 1-2 (1- 1- (1 (