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ABSTRACT Diversifying pastures with forage legumes may reduce nitrogen fertilization due to biological N fixation. This study aimed to quantify forage accumulation rate and macronutrients extraction and to identify the best intercropping combination between butterfly pea (Clitoria ternatea) – a legume, and three warm-season forage grasses of different growth habits (signalgrass – Urochloa decumbunes, Guinea grass - Mega thyrsus maximus, and bermudagrass Cynodon dactylon). Treatments consisted of mixes of perennial herbaceous legume, butterfly pea (twining stem), with grasses, signalgrass (decumbent stem) and Guinea grass (erect stem), and bermudagrass (stoloniferous/rhizomatous). The experiment was arranged in a randomized complete block design, with three treatments and three replications. There was interaction between the intercropping combinations and cutting cycles for forage accumulation rate (FAR) and N, P, K, Ca, Mg, and S uptake. Phosphorus and K uptake was reduced from the second cycle onwards, except for the signalgrass-butterfly pea intercropping, whose reduction was only from the third cycle. Conversely, the signalgrass-butterfly pea and bermudagrass-butterfly pea intercropping did not differ from each other in relation to total N concentration in soil, but the signalgrass-butterfly pea intercropping showed total N concentration in soil higher than that of Guinea grass-butterfly pea intercropping. A higher predominance of the N-NH4+ form was observed in the soil. Grass-legume intercropping increased the demand for nutrients, which makes it indispensable to verify the export of macronutrients to know when to supply these nutrients removed from the soil solution. fixation Clitoria ternatea legume warmseason warm season decumbunes maximus dactylon. dactylon . dactylon) twining stem, stem , decumbent erect stoloniferous/rhizomatous. stoloniferousrhizomatous stoloniferous/rhizomatous stoloniferous rhizomatous (stoloniferous/rhizomatous) design replications FAR (FAR P Ca Mg onwards signalgrassbutterfly Conversely bermudagrassbutterfly grassbutterfly NNH4+ NNH4 NNH NH4+ NH4 NH N-NH4 Grasslegume Grass solution (stoloniferous/rhizomatous N-NH

https://doi.org/10.36783/18069657rbcs20230141

Vaccine coverage by social strata in state capitals in the Brazilian Midwest region: a household survey of children born in 2017 and 2018 region 201 20 2
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Lima, Jaqueline Costa

; Garcia, Érica Marvila

; Oliveira, Sandra Maria do Valle Leone de

; Araújo, Wildo Navegantes de

; Lopes, Emmanuela Maria de Freitas

; Teles, Sheila Araújo

; Caetano, Karlla Antonieta Amorim

; Teixeira, Ana Izabel Passarela

; Alves, Bárbara Manuella Cardoso Sodré

; França, Ana Paula

; Moraes, José Cássio de

; Domingues, Carla Magda Allan Santos

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231308

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Analisar a cobertura vacinal completa em nascidos vivos em 2017 e 2018, nas capitais da região Centro-Oeste do Brasil, segundo estratos sociais. Métodos Inquérito domiciliar de base populacional com amostragem por conglomerados. Analisou-se a cobertura vacinal completa em crianças aos 12 e 24 meses de idade e os fatores sociodemográficos. Resultados Foram analisadas 5.715 crianças. A cobertura completa aos 12 meses de idade foi 67,9% (IC95% 65,4;70,4) e aos 24 meses de idade foi 48,2% (IC95% 45,3;51,1). A maior cobertura foi da vacina pneumococo (91,3%) e a pior da segunda dose da vacina rotavírus (74,2%). Em Campo Grande, nenhuma vacina alcançou cobertura acima de 90%, destacando-se as vacinas BCG (82,9%) e hepatite B (82,1%). Campo Grande e Brasília tiveram piores coberturas vacinais no estrato social alto (24 meses de idade). Conclusão A cobertura vacinal na região Centro-Oeste foi inferior a 80%, abaixo da meta preconizada e associada com fatores socioeconômicos. 201 2018 CentroOeste Centro Oeste Brasil sociais conglomerados Analisouse Analisou se 1 2 sociodemográficos 5715 5 715 5.71 679 67 9 67,9 IC95% IC95 IC (IC95 65,470,4 654704 65,4 70,4 65 4 70 65,4;70,4 482 48 48,2 45,351,1. 453511 45,3 51,1 . 45 3 51 45,3;51,1) 91,3% 913 91 (91,3% 74,2%. 742 74,2% 74 (74,2%) 90 90% destacandose destacando 82,9% 829 82 (82,9% 82,1%. 821 82,1% (82,1%) (2 idade. idade) 80 80% socioeconômicos 20 571 71 5.7 6 67, IC9 (IC9 470 65,470, 65470 654 65, 704 70, 7 65,4;70, 48, 351 45,351,1 45351 453 45, 511 51, 45,3;51,1 91,3 (91,3 74,2 (74,2% 82,9 8 (82,9 82,1 (82,1% ( 57 5. (IC 47 65,470 6547 65,4;70 35 45,351, 4535 45,3;51, 91, (91, 74, (74,2 82, (82, (82,1 65,47 65,4;7 45,351 45,3;51 (91 (74, (82 65,4; 45,35 45,3;5 (9 (74 (8 45,3; (7

ABSTRACT Objective To analyze full vaccination coverage in live births in 2017 and 2018 in the capitals of the Midwest region of Brazil, according to social strata. Methods Population-based household survey with cluster sampling. Full coverage in children at 12 and 24 months of age and sociodemographic factors were analyzed. Results 5,715 children were analyzed. Full coverage at 12 months of age was 67.9% (95%CI 65.4;70.4), while at 24 months it was 48.2% (95%CI 45.3;51.1). Pneumococcal vaccine had the highest vaccination coverage (91.3%), while the second dose of rotavirus vaccine had the lowest (74.2%). In Campo Grande, no vaccine reached coverage above 90%, with BCG (82.9%) and hepatitis B (82.1%) standing out. Campo Grande and Brasília had the worst vaccination coverage in the high social stratum (24 months of age). Conclusion Vaccination coverage in the Midwest was below 80%, falling short of the recommended target and associated with socioeconomic factors. 201 Brazil strata Populationbased Population based sampling 1 2 analyzed 5715 5 715 5,71 679 67 9 67.9 95%CI 95CI CI 95 65.470.4, 654704 65.4 70.4 , 65 4 70 65.4;70.4) 482 48 48.2 45.351.1. 453511 45.3 51.1 . 45 3 51 45.3;51.1) 91.3%, 913 91.3% 91 (91.3%) 74.2%. 742 74.2% 74 (74.2%) 90 90% 82.9% 829 82 (82.9% 82.1% 821 (82.1% out (2 age. age) 80 80% 20 571 71 5,7 6 67. 470 65.470.4 65470 654 65. 704 70. 7 65.4;70.4 48. 351 45.351.1 45351 453 45. 511 51. 45.3;51.1 91.3 (91.3% 74.2 (74.2% 82.9 8 (82.9 82.1 (82.1 ( 57 5, 47 65.470. 6547 65.4;70. 35 45.351. 4535 45.3;51. 91. (91.3 74. (74.2 82. (82. 65.470 65.4;70 45.351 45.3;51 (91. (74. (82 65.47 65.4;7 45.35 45.3;5 (91 (74 (8 65.4; 45.3; (9 (7

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https://doi.org/10.1590/s2237-96222024v33e20231308.especial2.en

Comparação dos casos de beribéri entre indígenas e não indígenas, Brasil, 2013 a 2018 Brasil 201 20 2
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Assunção, Anne Karine Martins

; Branco, Maria dos Remédios Freitas Carvalho

; Santos, Thiago de Sousa

; Costa, Silmery da Silva Brito

; Dias Júnior, José de Jesus

; Frota, Maria Tereza Borges Araújo

; Oliveira, Bruno Luciano Carneiro Alves de

; Santos, Alcione Miranda dos

Ciência & Saúde Coletiva

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jul 2023, Volume 28 N. 7 Pages 1993 - 2002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O beribéri é a manifestação clínica da deficiência grave e prolongada de tiamina (vitamina B1). Doença negligenciada que acomete a população de baixa renda, em situação de insegurança alimentar e nutricional. O objetivo do estudo foi comparar casos de beribéri em indígenas com casos em não indígenas no Brasil. Trata-se de estudo transversal de casos notificados de beribéri no período de 2013 a 2018, no formulário do SUS (FormSUS) do Ministério da Saúde. Foram comparados os casos em indígenas e em não indígenas pelo teste qui-quadrado ou teste exato de Fisher com nível de significância de p < 0,05. No período estudado foram notificados no país 414 casos de beribéri, sendo 210 (50,7%) indígenas. Referiram consumo de bebidas alcoólicas 58,1% dos indígenas e 71,6% dos não-indígenas (p = 0,004); adicionalmente, 71,0% dos indígenas consumiam caxiri (bebida alcoólica tradicional fermentada). Relataram fazer esforço físico diário 76,1% dos indígenas e 40,2% dos não-indígenas (p <0 ,001). Conclui-se que o beribéri no país acomete mais indígenas e está relacionado ao consumo de álcool e ao esforço físico. vitamina B1. B1 B . B1) renda nutricional Brasil Tratase Trata se 201 2018 FormSUS (FormSUS Saúde quiquadrado qui quadrado 005 0 05 0,05 41 21 50,7% 507 50 7 (50,7% 581 58 1 58,1 716 71 6 71,6 nãoindígenas 0,004 0004 004 0,004) adicionalmente 710 71,0 bebida fermentada. fermentada fermentada) 761 76 76,1 402 40 2 40,2 ,001. 001 ,001 ,001) Concluise Conclui 20 00 0,0 4 50,7 5 (50,7 58, 71, 0,00 000 76, 40, ,00 0, 50, (50, ,0 (50 , (5 (

Abstract Beriberi is the clinical manifestation of severe and prolonged thiamine (vitamin B1) deficiency. It is a neglected disease that affects low-income populations facing food and nutrition insecurity. The aim of this study was to compare cases of beriberi among indigenous and non-indigenous people in Brazil. We conducted a cross-sectional study using data on cases of beriberi during the period July 2013-September 2018 derived from beriberi notification forms available on the FormSUS platform. Cases in indigenous and non-indigenous patients were compared using the chi-squared test or Fisher’s exact test, adopting a significance level of 0.05. A total of 414 cases of beriberi were reported in the country during the study period, 210 of which (50.7%) were among indigenous people. Alcohol consumption was reported by 58.1% of the indigenous patients and 71.6% of the non-indigenous patients (p = 0.004); 71.0% of the indigenous patients reported that they consumed caxiri, a traditional alcoholic drink. Daily physical exertion was reported by 76.1% of the indigenous patients and 40.2% of the non-indigenous patients (p < 0.001). It is concluded that beriberi disproportionately affects indigenous people and is associated with alcohol consumption and physical exertion. vitamin B1 B deficiency lowincome low income insecurity nonindigenous non Brazil crosssectional cross sectional 2013September September 2013 201 platform chisquared chi squared Fishers Fisher s 005 0 05 0.05 41 21 50.7% 507 50 7 (50.7% 581 58 1 58.1 716 71 6 71.6 p 0.004 0004 004 0.004) 710 71.0 caxiri drink 761 76 76.1 402 40 2 40.2 0.001. 0001 0.001 . 001 0.001) 20 00 0.0 4 50.7 5 (50.7 58. 71. 0.00 000 76. 40. 0. 50. (50. (50 (5 (

https://doi.org/10.1590/1413-81232023287.16422022

Prejudice impairing quality of life in sickle cell disease patients in a developing country: faces of suffering country
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Rodrigues, Camila Freitas de Andrade

; Rodrigues, Thiago Alves

; Oliveira, Eduardo José Silva Gomes de

; Garcia, João Batista Santos

; Cartágenes, Maria do Socorro de Sousa

Hematology, Transfusion and Cell Therapy

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jul 2023, Volume 45 Suppl. 2 Pages S3 - S10

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: The perception of prejudice against, and stigmatization of, sickle cell disease (SCD) leads the patient to perceive a different treatment, due to the disease stigma and maybe related to a worse quality of life (QoL). Objectives: Describe and evaluate the perception of the prejudice against the disease and its impact on the quality of life of patients with sickle cell disease. Methods: This is a cross-sectional study conducted between March 2019 and February 2020, with patients diagnosed with SCD. Patients were questioned about the perception of prejudice in any kind of situation, choosing between “Yes” or “No”, not differentiating situations related to prejudice. To assess the QoL and impact of the disease, the volunteers answered a version of the SF-36 questionnaire translated and validated into Brazilian Portuguese. Results: In this study, 113 patients with SCD were followed up, 92% were classified as HbSS and the rest, divided between HbSC and HbS-β-0. Regarding the SF-36, the worst scores were in the summary of the physical components (mean 48.19 ± 21.51) and the physical aspect had the lowest mean (30.75 ± €42.65). When questioned if they had already perceived any kind of prejudice, including the SCD, 32.74% answered “Yes”. For this comparison, there was a significant difference in the summary of the physical and mental components, with worse QoL for those who had already suffered prejudice. Conclusion: Patients diagnosed with SCD who reported perception of prejudice had statistically significant worse QoL, revealing the negative impact, that might lead to sadness and social isolation. Introduction (SCD treatment QoL. . (QoL) Objectives Methods crosssectional cross sectional 201 2020 situation Yes “Yes No, No , “No” SF36 SF 36 SF-3 Portuguese Results 11 up 92 rest HbSβ0. HbSβ0 HbSβ HbS β 0. 0 HbS-β-0 SF36, 36, 4819 48 19 48.1 21.51 2151 21 51 30.75 3075 30 75 (30.7 €42.65. 4265 €42.65 42 65 €42.65) 3274 32 74 32.74 Yes. comparison Conclusion isolation (QoL 20 202 “No SF3 3 SF- 1 9 HbS-β- 481 4 48. 21.5 215 2 5 30.7 307 7 (30. 426 €42.6 6 327 32.7 HbS-β 21. 30. (30 €42. 32. (3 €42 ( €4 €

https://doi.org/10.1016/j.htct.2021.06.002

Comparação dos casos de beribéri entre indígenas e não indígenas, Brasil, 2013 a 2018
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Assunção, Anne Karine Martins

; Branco, Maria dos Remédios Freitas Carvalho

; Santos, Thiago de Sousa

; Costa, Silmery da Silva Brito

; Dias Júnior, José de Jesus

; Frota, Maria Tereza Borges Araújo

; Oliveira, Bruno Luciano Carneiro Alves de

; Santos, Alcione Miranda dos

Ciência & Saúde Coletiva

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jul 2023, Volume 28 N. 7 Pages 1993 - 2002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232023287.16422022

Characterization of Brazilian Buriti oil biomaterial: the influence on the physical, chemical properties and behaviour of Goat Wharton’s jelly mesenchymal stem cells biomaterial physical Whartons Wharton s
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Carvalho, Camila Ernanda Sousa de

; Reis, Fernando da Silva

; Silva, Elis Rosélia Dutra de Freitas Siqueira

; Bezerra, Dayseanny de Oliveira

; Pacheco, Isnayra Kerolaynne Carneiro

; Fialho, Ana Cristina Vasconcelos

; Matos, José Milton Elias de

; Melo, Wanderson Gabriel Gomes de

; Leite, Yulla Klinger Pereira de Carvalho

; Argôlo Neto, Napoleão Martins

; Carvalho, Maria Acelina Martins de

Animal Reproduction

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2023, Volume 20 N. 4 elocation e20230071

Abstract: En | Text: En | PDF: En

Abstract The Brazilian Buriti oil presents low extraction costs and relevant antioxidant properties. Thus, this work aimed to analyze Buriti oil biomaterial (BB), within its physicochemical properties, biocompatibility and cellular integration, with the purpose to the use as a growth matrix for Goat Wharton’s jelly mesenchymal stem cells. Biomaterials were produced from Buriti oil polymer (Mauritia flexuosa), for it’s characterization were performed Infrared Region Spectroscopy (FTIR) and Thermogravimetric Analysis (TG and DTG). The biointegration was analyzed by Scanning Electron Microscopy (SEM) and histological techniques. In order to investigate biocompatibility, MTT (3-(4,5-dimetil-2-tiazolil)-2,5-difenil-2H-tetrazólio) test and hemolytic activity tests were performed. The activation capacity of immune system cellswas measured by phagocytic capacity assay and nitric oxide synthesis . The BB presented an amorphous composition, with high thermal stability and high water expansion capacity, a surface with micro and macropores, and good adhesion of Wharton’s jelly mesenchymal stem cells (MSCWJ). We verified the absence of cytotoxicity and hemolytic activity, in addition, BB did not stimulate the activation of macrophages. Proving to be a safe material for direct cultivation and also for manufacturing of compounds used for in vivo applications. properties Thus BB, , (BB) integration Whartons Wharton s Mauritia flexuosa, flexuosa flexuosa) it FTIR (FTIR TG DTG. DTG DTG) SEM (SEM techniques 34,5dimetil2tiazolil2,5difenil2Htetrazólio 345dimetil2tiazolil25difenil2Htetrazólio dimetiltiazolildifenilHtetrazólio 3 4,5 dimetil 2 tiazolil 2,5 difenil 2H tetrazólio 4 5 H (3-(4,5-dimetil-2-tiazolil)-2,5-difenil-2H-tetrazólio composition macropores MSCWJ. MSCWJ (MSCWJ) addition macrophages applications (BB 34 5dimetil2tiazolil2 5difenil2Htetrazólio Htetrazólio 45 4, 25 2, (MSCWJ dimetiltiazolil 5dimetil2tiazolil difenilHtetrazólio

https://doi.org/10.1590/1984-3143-ar2023-0071

Environmental variables in the G x E interaction in soybean in the semiarid
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Albuquerque, José Ricardo Tavares de

; Lins, Hamurábi Anizio

; Santos, Manoel Galdino dos

; Freitas, Márcio Alexandre Moreira de

; Silveira, Lindomar Maria da

; Nunes, Glauber Henrique de Sousa

; Barros Júnior, Aurélio Paes

; Vieira, Paulo Fernando de Melo Jorge

Revista Ciência Agronômica

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2023, Volume 54 elocation e20218211

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo do presente trabalho foi avaliar a influência de variáveis ambientais na interação entre genótipos e ambientes e identificar genótipos adaptados e estáveis para a produção de sementes. Vinte e uma cultivares foram avaliadas em blocos ao acaso com quatro repetições nos anos de 2016, 2017 e 2018 no semiárido nordestino do Brasil, para rendimento de sementes e teor de óleo. Metodologias de regressão fatorial e análise de componentes principais foram utilizadas com previsões da soma dos efeitos genotípicos e a interação para quantificar o papel de cinco covariáveis ambientais na interação genótipo x ambiente; o Método da Média Harmônica de Desempenho Relativo de Valores Genotípicos foi usado para identificar genótipos adaptados e estáveis. O modelo biplot de covariância é útil para relacionar fatores ambientais importantes e indicar seu efeito relativo no rendimento de sementes e no teor de óleo. A precipitação, a umidade relativa e a temperatura máxima contribuem positivamente para aumentar o teor de óleo, enquanto a temperatura mínima e a radiação solar o reduzem. Dentro dos limites do trabalho, a temperatura máxima influencia positivamente a produção de grãos enquanto a mínima a reduz. Os genótipos mais estáveis e adaptados para rendimento de sementes de grãos e teor de óleo são BMX OPUS IPRO, P 98Y70 RR, BRS 333 RR, BRS 9280 RR, M 8644 IPRO, M 8372 IPRO e ST 920 RR. 2016 201 Brasil ambiente precipitação reduzem reduz Y 98Y7 RR 33 928 864 837 92 20 98Y 3 86 83 9 2 8

ABSTRACT The objective of the present work was to evaluate the influence of environmental variables on the interaction between genotypes and environments and to identify adapted and stable genotypes for grain seed yield. Twenty-one cultivars were evaluated in randomized blocks with four replications in the years 2016, 2017, and 2018 in the northeastern semi-arid region of Brazil, for seed yield and oil content. Factor regression methodologies and principal component analysis were used with predictions of the sum of the genotypic effects and the interaction to quantify the role of five environmental covariates in the genotype x environment interaction; the Harmonic Mean Method of Relative Performance of Genotypic Values was used for identifying adapted and stable genotypes. The covariance biplot model is useful for relating important environmental factors and indicating their relative effect on seed yield and oil content. Rainfall, relative humidity and maximum temperature contribute positively to increasing oil content while minimum temperature and solar radiation reduce it. Within the limits of the work, the maximum temperature positively influences grain production while the minimum reduces it. The most stable genotypes and those adapted for grain seed yield and oil content are BMX OPUS IPRO, P 98Y70 RR, BRS 333 RR, BRS 9280 RR, M 8644 IPRO, M 8372 IPRO, and ST 920 RR. Twentyone Twenty one 2016 2017 201 semiarid semi arid Brazil Rainfall it IPRO Y 98Y7 RR 33 928 864 837 92 20 98Y 3 86 83 9 2 8

https://doi.org/10.5935/1806-6690.20230019

Brazilian guidelines for the pharmacological treatment of the pulmonary symptoms of cystic fibrosis. Official document of the Sociedade Brasileira de Pneumologia e Tisiologia (SBPT, Brazilian Thoracic Association) fibrosis SBPT, SBPT (SBPT Association
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Athanazio, Rodrigo Abensur

; Tanni, Suzana Erico

; Ferreira, Juliana

; Dalcin, Paulo de Tarso Roth

; Fuccio, Marcelo B de

; Esposito, Concetta

; Canan, Mariane Gonçalves Martynychen

; Coelho, Liana Sousa

; Firmida, Mônica de Cássia

; Almeida, Marina Buarque de

; Marostica, Paulo José Cauduro

; Monte, Luciana de Freitas Velloso

; Souza, Edna Lúcia

; Pinto, Leonardo Araujo

; Rached, Samia Zahi

; Oliveira, Verônica Stasiak Bednarczuk de

; Riedi, Carlos Antonio

; Silva Filho, Luiz Vicente Ribeiro Ferreira da

Jornal Brasileiro de Pneumologia

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2023, Volume 49 N. 2 elocation e20230040

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A fibrose cística (FC) é uma doença genética que resulta em disfunção da proteína reguladora de condutância transmembrana da FC (CFTR), que é um canal de cloro e bicarbonato expresso na porção apical de células epiteliais de diversos órgãos. A disfunção dessa proteína resulta em manifestações clínicas diversas, envolvendo primariamente os sistemas respiratório e gastrointestinal com redução da qualidade e expectativa de vida. A FC ainda é uma patologia incurável, porém o horizonte terapêutico e prognóstico é hoje totalmente distinto e muito mais favorável. O objetivo destas diretrizes foi definir recomendações brasileiras baseadas em evidências em relação ao emprego de agentes farmacológicos no tratamento pulmonar da FC. As perguntas PICO (acrônimo baseado em perguntas referentes aos Pacientes de interesse, Intervenção a ser estudada, Comparação da intervenção e Outcome [desfecho] de interesse) abordaram aspectos relativos ao uso de moduladores de CFTR (ivacaftor, lumacaftor + ivacaftor e tezacaftor + ivacaftor), uso de dornase alfa, terapia de erradicação e supressão crônica de Pseudomonas aeruginosa, e erradicação de Staphylococcus aureus resistente a meticilina e do complexo Burkholderia cepacia. Para a formulação das perguntas, um grupo de especialistas brasileiros foi reunido e realizou-se uma revisão sistemática sobre os temas, com meta-análise quando aplicável. Os resultados encontrados foram analisados quanto à força das evidências compiladas, sendo concebidas recomendações seguindo a metodologia GRADE. Os autores acreditam que o presente documento represente um importante avanço a ser incorporado na abordagem de pacientes com FC, objetivando principalmente favorecer seu manejo, podendo se tornar uma ferramenta auxiliar na definição de políticas públicas relacionadas à FC. (FC CFTR, , (CFTR) órgãos diversas vida incurável favorável acrônimo interesse estudada desfecho [desfecho ivacaftor, (ivacaftor ivacaftor) alfa aeruginosa cepacia realizouse realizou temas metaanálise meta análise aplicável compiladas GRADE manejo (CFTR

ABSTRACT Cystic fibrosis (CF) is a genetic disease that results in dysfunction of the CF transmembrane conductance regulator (CFTR) protein, which is a chloride and bicarbonate channel expressed in the apical portion of epithelial cells of various organs. Dysfunction of that protein results in diverse clinical manifestations, primarily involving the respiratory and gastrointestinal systems, impairing quality of life and reducing life expectancy. Although CF is still an incurable pathology, the therapeutic and prognostic perspectives are now totally different and much more favorable. The purpose of these guidelines is to define evidence-based recommendations regarding the use of pharmacological agents in the treatment of the pulmonary symptoms of CF in Brazil. Questions in the Patients of interest, Intervention to be studied, Comparison of interventions, and Outcome of interest (PICO) format were employed to address aspects related to the use of modulators of this protein (ivacaftor, lumacaftor+ivacaftor, and tezacaftor+ivacaftor), use of dornase alfa, eradication therapy and chronic suppression of Pseudomonas aeruginosa, and eradication of methicillin-resistant Staphylococcus aureus and Burkholderia cepacia complex. To formulate the PICO questions, a group of Brazilian specialists was assembled and a systematic review was carried out on the themes, with meta-analysis when applicable. The results obtained were analyzed in terms of the strength of the evidence compiled, the recommendations being devised by employing the GRADE approach. We believe that these guidelines represent a major advance to be incorporated into the approach to patients with CF, mainly aiming to favor the management of the disease, and could become an auxiliary tool in the definition of public policies related to CF. (CF CFTR (CFTR organs manifestations systems expectancy pathology favorable evidencebased based Brazil studied interventions (PICO ivacaftor, ivacaftor (ivacaftor lumacaftorivacaftor lumacaftor lumacaftor+ivacaftor tezacaftor+ivacaftor, tezacaftorivacaftor tezacaftor+ivacaftor , tezacaftor tezacaftor+ivacaftor) alfa aeruginosa methicillinresistant methicillin resistant complex questions themes metaanalysis meta analysis applicable compiled

https://doi.org/10.36416/1806-3756/e20230040

10.

Influence of genotype-environment interaction on soybean (Glycine max L.) genetic divergence under semiarid conditions
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Tavares de Albuquerque, José Ricardo

; Lins, Hamurábi Anizio

; Galdino dos Santos, Manoel

; Moreira de Freitas, Márcio Alexandre

; Sarmento de Oliveira, Fernando

; Evangelista de Souza, Almir Rogério

; da Silveira, Lindomar Maria

; de Sousa Nunes, Glauber Henrique

; Paes Barros Júnior, Aurélio

; de Melo Jorge Vieira, Paulo Fernando

Revista de la Facultad de Ciencias Agrarias. Universidad Nacional de Cuyo

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jun 2022, Volume 54 N. 1 Pages 1 - 12

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El objetivo del presente trabajo fue evaluar la influencia de la interacción genotipo por ambiente en estudios de divergencia genética en soja en condiciones semiáridas. Se realizaron cuatro experimentos con un diseño de bloques completos aleatorizados con cuatro repeticiones donde se evaluaron 21 genotipos de soja. Se utilizaron los siguientes descriptores para cuantificar la divergencia: altura de planta, materia seca, contenido de aceite, número de vainas por planta, número de granos por vaina, peso de cien semillas, rendimiento, días a floración y días a maduración. Se utilizó el método jerárquico UPGMA para agrupar los genotipos de la matriz de distancias de Mahalanobis mediante las medias genotípicas estimadas por el método REML / BLUP. La agrupación de genotipos depende de las condiciones de evaluación, principalmente debido a los efectos de la interacción genotipo por años. El análisis conjunto, sin la presencia del efecto de interacción, permite obtener dos grupos de genotipos. Los cruzamientos más adecuados involucran los genotipos BRS Tracajá, BRS Pérola, BRS Carnaúba, M 8644 IPRO, BRS 8590 y BMX OPUS IPRO, y el genotipo BRS Sambaíba, especialmente el entre BMX OPUS IPRO y el genotipo BRS Sambaíba, que es el de mayor disimilitud.

Abstract The objective of the present work was to evaluate the influence of the genotype-envi ronment interaction on genetically divergent soybean grown under semiarid conditions. Four experiments were carried out in randomized blocks with four replicates to evaluate twenty-one soybean genotypes. The following descriptors were used to quantify diver gence: plant height, dry matter, oil content, number of pods per plant, number of grains per pod, the weight of 100 seeds, yield, days for flowering, and days for maturation. The unweighted pair group method with arithmetic mean was used to group the genotypes from the Mahalanobis distance matrix estimated using the genotypic means estimated by the REML/BLUP method. The grouping of genotypes depended mainly on the effects of the interaction between genotypes and years. The joint analysis, without the effect of the inter action, allowed us to obtain two groups of genotypes. The most recommended crosses were those of the lines BRS Tracajá, BRS Pérola, BRS Carnaúba, M 8644 IPRO, BRS 8590, and BMX OPUS IPRO with the genotype BRS Sambaíba, especially the one between BMX OPUS IPRO and BRS Sambaíba.

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11.

[SciELO Preprints] - The Knowledge and Prescription of Pre-Exposure Prophylaxis for HIV by Physicians in Goiás
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Bernardes, Cristiane Teixeira Vilhena Port, Maria Eduarda Freire, Manuelle Quixabeira Souza, Izabella Gomes de Rocha, Julia Sousa Borges, Naiza Murielly Pereira Freitas, Yago José Fagundes de

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Publication date: 2022-04-29

Abstract: En Pt

The acquired immunodeficiency syndrome (AIDS) is a disease which effects the immune system and, to reduce the development of this pathology, antiretrovirals was created. Evidences demonstrate the effectiveness of Pre-Exposure Prophylaxis (PrEP), however, it still has obstacles, such as the lack of knowledge, technique and training of health professionals for patient guidance and prescription. The aim of this research is to investigate the subjective and objective knowledge of PrEP, futhermore the number of prescriptions in State of Goiás. For data collection, a survey was applied to 152 physicians with active enrollment in Conselho Regional de Medicina do Estado de Goiás. As a result, 132 physicians (86,8%) reported having previous knowledge about PrEP, on average of 44,2% informed having knowledge for prescription, 129 (84,8%) never prescribed PrEP and, when objectively evaluated, on average of 83,8% have knowledge about the risk categorization for the drug use. The outcome of this research is not consonant with the hypothesis that only 20% of the physicians would have plenty knowledge, according to the literature, but it is evident the need for medical training to optimize the clinical impact on public health of this important HIV prevention strategy.

A Síndrome da Imunodeficiência Adquirida é uma infecção que acomete o sistema imunológico e, para redução da propagação dessa patologia, desenvolveu-se os antirretrovirais. Evidências demonstram a eficácia da Profilaxia Pré-Exposição (PrEP), mas ainda com obstáculos, como a falta de conhecimento, técnica e treinamento dos profissionais de saúde para a sua orientação e prescrição. O objetivo dessa pesquisa é investigar o conhecimento subjetivo, objetivo e prescrição da PrEP por médicos do Estado de Goiás. Para a coleta de dados foi aplicado um questionário à 152 médicos com inscrição ativa no Conselho Regional de Medicina do Estado de Goiás. Como resultado, 132 médicos (86,8%) afirmaram possuir conhecimento prévio sobre a PrEP, em média 44,2% informaram ter conhecimento para prescrição, 129 (84,8%) nunca prescreveram PrEP e, quando avaliado objetivamente, em média 83,8% possuem conhecimento sobre a categorização de risco para o uso do medicamento. Os resultados dessa pesquisa não estão em consonância com a hipótese de que apenas 20% dos médicos teriam conhecimento suficiente, de acordo com a literatura, mas é evidente a necessidade de capacitação médica visando otimizar o impacto clínico na saúde pública desta importante estratégia de prevenção do HIV.

https://doi.org/10.1590/SciELOPreprints.4042

12.

Assessment and Associations between Quality of Life and Risk of Suicide
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Melo, Cynthia de Freitas

; Vasconcelos Filho, José Eurico de

; Costa, Icaro Moreira

; Cavalcante, Ana Karine Sousa

; Silva, Sabrina Magalhães Martins da

; Freitas Filho, Ronaldo Almeida de

Psico-USF

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jan 2022, Volume 27 N. 1 Pages 61 - 72

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Este estudo objetivou verificar em que medida os níveis de qualidade de vida se relacionam e influenciam os índices de risco de suicídio. Realizou-se uma pesquisa descritiva, correlacional, de abordagem quantitativa. Contou-se com uma amostra não probabilística composta por 11.863 participantes - brasileiros e maiores de 18 anos, que responderam à Risk Assessment Suicide Scale (RASS) e ao Word Health Organization Quality of Life Instrument Bref(WHOQOL-bref), cujos dados foram analisados por meio de estatística descritiva, correlação de Spearman e regressão linear multivariada pormeio do Statistical Package for Social Science (SPSS). Os resultados identificam correlações negativas, moderadas e significativas entre os construtos; e que os domínios de qualidade de vida influenciam em 47,8% as variações nos índices de risco de suicídio, constatando que o domínio psicológico é o mais relevante dentro do modelo explicativo criado. Conclui-se a necessidade de políticas públicas para melhoria da qualidade de vida e prevenção de suicídio.

Abstract This study aimed to verify the extent to which the levels of quality of life are related to and influence suicide risk indices. A descriptive, correlational, quantitative research was performed. A non-probabilistic sample was used which was composed of 11,863 Brazilian participants all over 18 years old, who responded to the Risk Assessment Suicide Scale (RASS) and the World Health Organization Quality of Life BREF Instrument (WHOQOL-BREF), and whose data were analyzed by using descriptive statistics, the Spearman correlation and multiple linear regression using the Statistical Package for Social Sciences (SPSS). The results identify negative, moderate and significant correlations between the constructs, and that the domains of quality of life influence 47.8% of the variations in the suicide risk indices, confirming that the psychological domain is the most relevant within the explanatory model created. The conclusion is that there is a the need for public policies to improve the quality of life and prevent suicide.

Resumen Este estudio objetivó comprobar hasta qué medida los niveles de calidad de vida se relacionan e influyen en las tasas de riesgo de suicidio. Se realizó una investigación descriptiva, correlacional y cuantitativa. Hubo una muestra no probabilística compuesta por 11.863 participantes brasileños mayores de 18 años, que respondieron a la Risk Assessment Suicide Scale (RASS) y al Word Health Organization Quality of Life Instrument Bref(WHOQOL-bref), cuyos datos fueron analizados mediante estadística descriptiva, correlación de Spearman y regresión lineal multivariante en Statistical Package for Social Science (SPSS). Los resultados identifican correlaciones negativas, moderadas y significativas entre los constructos; y que los dominios de calidad de vida influyen en un 47,8% en las variaciones de los índices de riesgo de suicidio, encontrando que el dominio psicológico es el más relevante dentro del modelo explicativo creado. Estos hallazgos revelan la necesidad de políticas públicas para mejorar la calidad de vida y prevenir el suicidio.

https://doi.org/10.1590/1413-82712022270105

13.

SECOND BRAZILIAN CONSENSUS ON THE MANAGEMENT OF ULCERATIVE COLITIS IN ADULTS: A CONSENSUS OF THE BRAZILIAN ORGANIZATION FOR CROHN’S DISEASE AND COLITIS (GEDIIB) ADULTS CROHNS CROHN S GEDIIB (GEDIIB
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BAIMA, Júlio Pinheiro

; IMBRIZI, Marcello

; ANDRADE, Adriana Ribas

; CHEBLI, Liliane Andrade

; ARGOLLO, Marjorie Costa

; QUEIROZ, Natália Sousa Freitas

; AZEVEDO, Matheus Freitas Cardoso de

; VIEIRA, Andrea

; COSTA, Marcia Henriques de Magalhães

; FRÓES, Renata de Sá Brito

; PENNA, Francisco Guilherme Cancela e

; QUARESMA, Abel Botelho

; DAMIÃO, Aderson Omar Mourão Cintra

; MORAES, Antonio Carlos da Silva

; SANTOS, Carlos Henrique Marques dos

; FLORES, Cristina

; ZALTMAN, Cyrla

; VILELA, Eduardo Garcia

; MORSOLETTO, Eloá

; GONÇALVES FILHO, Francisco de Assis

; SANTANA, Genoile Oliveira

; ZABOT, Gilmara Pandolfo

; PARENTE, José Miguel Luz

; SASSAKI, Ligia Yukie

; ZERÔNCIO, Marco Antonio

; MACHADO, Marta Brenner

; CASSOL, Ornella Sari

; KOTZE, Paulo Gustavo

; PARRA, Rogerio Serafim

; MISZPUTEN, Sender Jankiel

; COY, Cláudio Saddy Rodrigues

; AMBROGINI JUNIOR, Orlando

; CHEBLI, Júlio Maria Fonseca

; SAAD-HOSSNE, Rogério

Arquivos de Gastroenterologia

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2022, Volume 59 Suppl. 1 Pages 51 - 84

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: As doenças inflamatórias intestinais são doenças imunomediadas que incluem a doença de Crohn (DC) e a retocolite ulcerativa (RCU). A RCU é uma doença progressiva que acomete a mucosa colorretal causando sintomas debilitantes levando a alta morbidade e incapacidade laboral. Como consequência da inflamação crônica do cólon, a RCU também está associada a um risco aumentado de câncer colorretal. Objetivo: Este consenso visa fornecer orientações sobre o manejo médico mais eficaz de pacientes adultos com RCU. Métodos: As recomendações do consenso foram desenvolvidas por gastroenterologistas e cirurgiões colorretais referências no Brasil (membros da Organização Brasileira para Doença de Crohn e Colite [GEDIIB]). Uma revisão sistemática, incluindo as evidências mais recentes, foi conduzida para apoiar as recomendações. Todas as recomendações foram endossadas pelas partes interessadas/especialistas em doença inflamatória intestinal usando um Painel Delphi modificado. O nível de concordância para alcançar consenso foi de 80% ou mais. Resultados e conclus ão: As recomendações médicas (farmacológicas e não farmacológicas) foram mapeadas de acordo com o estágio de tratamento e gravidade da doença em três domínios: manejo e tratamento (intervenções medicamentosas e cirúrgicas), critérios para avaliar a eficácia do tratamento médico, e acompanhamento/monitoramento do paciente após o tratamento inicial. O consenso foi direcionado a clínicos gerais, gastroenterologistas e cirurgiões que tratam pacientes com RCU e apoia os processos de tomada de decisão por companhias de seguro de saúde, agências reguladoras, líderes institucionais de saúde e administradores. Contexto DC (DC . (RCU) laboral cólon Objetivo Métodos membros GEDIIB. GEDIIB [GEDIIB]) sistemática recentes interessadasespecialistas interessadas especialistas modificado 80 ão farmacológicas domínios intervenções cirúrgicas, cirúrgicas , cirúrgicas) acompanhamentomonitoramento acompanhamento monitoramento inicial gerais reguladoras administradores (RCU [GEDIIB] 8 [GEDIIB

ABSTRACT Background: Inflammatory bowel diseases are immune-mediated disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). UC is a progressive disease that affects the colorectal mucosa causing debilitating symptoms leading to high morbidity and work disability. As a consequence of chronic colonic inflammation, UC is also associated with an increased risk of colorectal cancer. Objective: This consensus aims to provide guidance on the most effective medical management of adult patients with UC. Methods: A consensus statement was developed by stakeholders representing Brazilian gastroenterologists and colorectal surgeons (Brazilian Organization for Crohn’s Disease and Colitis [GEDIIB]). A systematic review including the most recent evidence was conducted to support the recommendations and statements. All recommendations/statements were endorsed using a modified Delphi Panel by the stakeholders/experts in inflammatory bowel disease with at least 80% or greater consensus. Results and conclusion: The medical recommendations (pharmacological and non-pharmacological) were mapped according to the stage of treatment and severity of the disease onto three domains: management and treatment (drug and surgical interventions), criteria for evaluating the effectiveness of medical treatment, and follow-up/patient monitoring after initial treatment. The consensus targeted general practitioners, gastroenterologists and surgeons who manage patients with UC, and supports decision-making processes by health insurance companies, regulatory agencies, health institutional leaders, and administrators. Background immunemediated immune mediated Crohns Crohn s CD (CD . (UC) disability inflammation cancer Objective Methods GEDIIB. GEDIIB [GEDIIB]) statements recommendationsstatements stakeholdersexperts experts 80 conclusion pharmacological nonpharmacological non non-pharmacological domains drug interventions, interventions , interventions) followup/patient followuppatient follow up/patient up patient practitioners decisionmaking decision making companies agencies leaders administrators (UC [GEDIIB] 8 followup uppatient [GEDIIB

https://doi.org/10.1590/s0004-2803.2022005s1-03

14.

Análise espacial da taxa de detecção de casos suspeitos de síndrome congênita pelo vírus Zika, Maranhão, 2015 a 2018
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Falcão Neto, Paulo Afonso de Oliveira

; Branco, Maria dos Remédios Freitas Carvalho

; Costa, Silmery da Silva Brito

; Câmara, Ana Patrícia Barros

; Marques, Thayná Millena Nunes França

; Araujo, Adriana Soraya

; Loureiro, Flávia Helen Furtado

; Dias Júnior, José de Jesus

; Silva, Maria do Socorro da

; Queiroz, Rejane Christine de Sousa

; Ribeiro, Marizélia Rodrigues Costa

; Kulkarni, Manisha Ann

; Silva, Antônio Augusto Moura da

; Santos, Alcione Miranda dos

Revista Brasileira de Epidemiologia

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2022, Volume 25 elocation e220002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Objetivo: Identificar padrões espaciais em casos de lactentes com alterações de crescimento e desenvolvimento relacionadas à infecção pelo vírus Zika e outras etiologias infecciosas (neste trabalho denominado de síndrome congênita pelo vírus Zika), notificados no Maranhão de 2015 a 2018 e sua relação com variáveis socioeconômicas e demográficas. Métodos: Estudo ecológico de casos suspeitos notificados de síndrome congênita pelo vírus Zika nos 217 municípios do Maranhão, Brasil. Calculou-se a autocorrelação espacial pelos índices de Moran local e global (I) univariado e bivariado da taxa de detecção de casos suspeitos de síndrome congênita pelo vírus Zika com índice de desenvolvimento humano municipal, densidade demográfica, índice de Gini e tempo de emancipação político-administrativa dos municípios. O índice de Moran local foi calculado para localizar clusters com autocorrelação espacial significativa. Resultados: Houve autocorrelação espacial na análise univariada da taxa municipal de detecção de casos suspeitos de síndrome congênita pelo vírus Zika (I=0,494; p=0,001) e, na análise bivariada, correlação positiva da taxa de detecção de casos suspeitos com índice de desenvolvimento humano municipal (I=0,252; p=0,001), densidade demográfica (I=0,338; p=0,001) e tempo de emancipação dos municípios (I=0,134; p=0,001). Não houve correlação significativa da taxa de detecção de casos suspeitos com o índice de Gini (I= -0,033; p=0,131). Cinco clusters de alta detecção de casos suspeitos foram encontrados em áreas distintas do estado. Conclusões: Os municípios com maior índice de desenvolvimento humano municipal, maior densidade demográfica e mais tempo de emancipação político-administrativa tiveram mais casos suspeitos notificados de síndrome congênita pelo vírus Zika.

ABSTRACT: Objective: To identify spatial patterns in cases of changes in growth and development related to Zika virus infection and other infectious etiologies (denominated Zika virus congenital syndrome in this study) reported in Maranhão from 2015 to 2018 and their relation with socioeconomic and demographic variables. Methods: Ecological study of notified Zika virus congenital syndrome cases in the 217 cities of Maranhão, Brasil. Spatial autocorrelation was calculated using GeoDa 1.14 software and the local and global (I) Moran’s index in univariate and bivariate analyses on Zika virus congenital syndrome incidence rate with Municipal Human Development Index (MHDI), population density, Gini coefficient and the cities’ time of administrative political emancipation. Local Moran’s Index was calculated to identify clusters with significant spatial autocorrelation. Results: Spatial autocorrelation was checked in univariate analysis of the incidence rate of Zika virus congenital syndrome (I=0,494; p=0,001) and positive correlation in bivariate analysis of the incidence rate with Municipal Human Development Index (I=0,252; p=0,001), population density (I=0,338; p=0,001) and the cities’ time of administrative political emancipation (I=0,134; p=0,001). The correlation between incidence rate with Gini coefficient was not significant (I= -0,033; p=0,131). Five high-incidence clusters were found in distinct areas of the state. Conclusions: Cities with higher MHDI, higher population density and more years of administrative political emancipation had more cases of Zika virus congenital syndrome notified.

https://doi.org/10.1590/1980-549720220002

15.

Análise espacial da taxa de detecção de casos suspeitos de síndrome congênita pelo vírus Zika, Maranhão, 2015 a 2018
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Falcão Neto, Paulo Afonso de Oliveira

; Branco, Maria dos Remédios Freitas Carvalho

; Costa, Silmery da Silva Brito

; Câmara, Ana Patrícia Barros

; Marques, Thayná Millena Nunes França

; Araujo, Adriana Soraya

; Loureiro, Flávia Helen Furtado

; Dias Júnior, José de Jesus

; Silva, Maria do Socorro da

; Queiroz, Rejane Christine de Sousa

; Ribeiro, Marizélia Rodrigues Costa

; Kulkarni, Manisha Ann

; Silva, Antônio Augusto Moura da

; Santos, Alcione Miranda dos

Revista Brasileira de Epidemiologia

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2022, Volume 25 elocation e220002

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1980-549720220002

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