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1.
IMPACTO-MR: um estudo brasileiro de plataforma nacional para avaliar infecções e multirresistência em unidades de terapia intensiva IMPACTOMR IMPACTO MR IMPACTO-MR
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Tomazini, Bruno M
; Nassar Jr, Antonio Paulo
; Lisboa, Thiago Costa
; Azevedo, Luciano César Pontes de
; Veiga, Viviane Cordeiro
; Catarino, Daniela Ghidetti Mangas
; Fogazzi, Debora Vacaro
; Arns, Beatriz
; Piastrelli, Filipe Teixeira
; Dietrich, Camila
; Negrelli, Karina Leal
; Jesuíno, Isabella de Andrade
; Reis, Luiz Fernando Lima
; Mattos, Renata Rodrigues de
; Pinheiro, Carla Cristina Gomes
; Luz, Mariane Nascimento
; Spadoni, Clayse Carla da Silva
; Moro, Elisângela Emilene
; Bueno, Flávia Regina
; Sampaio, Camila Santana Justo Cintra
; Silva, Débora Patrício
; Baldassare, Franca Pellison
; Silva, Ana Cecilia Alcantara
; Veiga, Thabata
; Barbante, Leticia
; Lambauer, Marianne
; Campos, Viviane Bezerra
; Santos, Elton
; Santos, Renato Hideo Nakawaga
; Laranjeiras, Ligia Nasi
; Valeis, Nanci
; Santucci, Eliana
; Miranda, Tamiris Abait
; Patrocínio, Ana Cristina Lagoeiro do
; Carvalho, Andréa de
; Sousa, Eduvirgens Maria Couto de
; Sousa, Ancelmo Honorato Ferraz de
; Malheiro, Daniel Tavares
; Bezerra, Isabella Lott
; Rodrigues, Mirian Batista
; Malicia, Julliana Chicuta
; Silva, Sabrina Souza da
; Gimenes, Bruna dos Passos
; Sesin, Guilhermo Prates
; Zavascki, Alexandre Prehn
; Sganzerla, Daniel
; Medeiros, Gregory Saraiva
; Santos, Rosa da Rosa Minho dos
; Silva, Fernanda Kelly Romeiro
; Cheno, Maysa Yukari
; Abrahão, Carolinne Ferreira
; Oliveira Junior, Haliton Alves de
; Rocha, Leonardo Lima
; Nunes Neto, Pedro Aniceto
; Pereira, Valéria Chagas
; Paciência, Luis Eduardo Miranda
; Bueno, Elaine Silva
; Caser, Eliana Bernadete
; Ribeiro, Larissa Zuqui
; Fernandes, Caio Cesar Ferreira
; Garcia, Juliana Mazzei
; Silva, Vanildes de Fátima Fernandes
; Santos, Alisson Junior dos
; Machado, Flávia Ribeiro
; Souza, Maria Aparecida de
; Ferronato, Bianca Ramos
; Urbano, Hugo Corrêa de Andrade
; Moreira, Danielle Conceição Aparecida
; Souza-Dantas, Vicente Cés de
; Duarte, Diego Meireles
; Coelho, Juliana
; Figueiredo, Rodrigo Cruvinel
; Foreque, Fernanda
; Romano, Thiago Gomes
; Cubos, Daniel
; Spirale, Vladimir Miguel
; Nogueira, Roberta Schiavon
; Maia, Israel Silva
; Zandonai, Cassio Luis
; Lovato, Wilson José
; Cerantola, Rodrigo Barbosa
; Toledo, Tatiana Gozzi Pancev
; Tomba, Pablo Oscar
; Almeida, Joyce Ramos de
; Sanches, Luciana Coelho
; Pierini, Leticia
; Cunha, Mariana
; Sousa, Michelle Tereza
; Azevedo, Bruna
; Dal-Pizzol, Felipe
; Damasio, Danusa de Castro
; Bainy, Marina Peres
; Beduhn, Dagoberta Alves Vieira
; Jatobá, Joana D’Arc Vila Nova
; Moura, Maria Tereza Farias de
; Rego, Leila Rezegue de Moraes
; Silva, Adria Vanessa da
; Oliveira, Luana Pontes
; Sodré Filho, Eliene Sá
; Santos, Silvana Soares dos
; Neves, Itallo de Lima
; Leão, Vanessa Cristina de Aquino
; Paes, João Lucidio Lobato
; Silva, Marielle Cristina Mendes
; Oliveira, Cláudio Dornas de
; Santiago, Raquel Caldeira Brant
; Paranhos, Jorge Luiz da Rocha
; Wiermann, Iany Grinezia da Silva
; Pedroso, Durval Ferreira Fonseca
; Sawada, Priscilla Yoshiko
; Prestes, Rejane Martins
; Nascimento, Glícia Cardoso
; Grion, Cintia Magalhães Carvalho
; Carrilho, Claudia Maria Dantas de Maio
; Dantas, Roberta Lacerda Almeida de Miranda
; Silva, Eliane Pereira
; Silva, Antônio Carlos da
; Oliveira, Sheila Mara Bezerra de
; Golin, Nicole Alberti
; Tregnago, Rogerio
; Lima, Valéria Paes
; Silva, Kamilla Grasielle Nunes da
; Boschi, Emerson
; Buffon, Viviane
; Machado, André Sant’Ana
; Capeletti, Leticia
; Foernges, Rafael Botelho
; Carvalho, Andréia Schubert de
; Oliveira Junior, Lúcio Couto de
; Oliveira, Daniela Cunha de
; Silva, Everton Macêdo
; Ribeiro, Julival
; Pereira, Francielle Constantino
; Salgado, Fernanda Borges
; Deutschendorf, Caroline
; Silva, Cristofer Farias da
; Gobatto, Andre Luiz Nunes
; Oliveira, Carolaine Bomfim de
; Dracoulakis, Marianna Deway Andrade
; Alvaia, Natália Oliveira Santos
; Souza, Roberta Machado de
; Araújo, Larissa Liz Cardoso de
; Melo, Rodrigo Morel Vieira de
; Passos, Luiz Carlos Santana
; Vidal, Claudia Fernanda de Lacerda
; Rodrigues, Fernanda Lopes de Albuquerque
; Kurtz, Pedro
; Shinotsuka, Cássia Righy
; Tavares, Maria Brandão
; Santana, Igor das Virgens
; Gavinho, Luciana Macedo da Silva
; Nascimento, Alaís Brito
; Pereira, Adriano J
; Cavalcanti, Alexandre Biasi
.
RESUMO Objetivo: Descrever o IMPACTO-MR, um estudo brasileiro de plataforma nacional em unidades de terapia intensiva focado no impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Métodos: Descrevemos a plataforma IMPACTO-MR, seu desenvolvimento, critérios para seleção das unidades de terapia intensiva, caracterização da coleta de dados, objetivos e projetos de pesquisa futuros a serem realizados na plataforma. Resultados: Os dados principais foram coletados por meio do Epimed Monitor System® e consistiram em dados demográficos, dados de comorbidades, estado funcional, escores clínicos, diagnóstico de internação e diagnósticos secundários, dados laboratoriais, clínicos e microbiológicos e suporte de órgãos durante a internação na unidade de terapia intensiva, entre outros. De outubro de 2019 a dezembro de 2020, 33.983 pacientes de 51 unidades de terapia intensiva foram incluídos no banco de dados principal. Conclusão: A plataforma IMPACTO-MR é um banco de dados clínico brasileiro de unidades de terapia intensiva focado na pesquisa do impacto das infecções por bactérias multirresistentes relacionadas à assistência à saúde. Essa plataforma fornece dados para o desenvolvimento e pesquisa de unidades de terapia intensiva individuais e ensaios clínicos observacionais e prospectivos multicêntricos. Objetivo IMPACTOMR, IMPACTOMR IMPACTO MR, MR saúde Métodos Resultados System demográficos comorbidades funcional secundários laboratoriais outros 201 2020 33983 33 983 33.98 5 principal Conclusão multicêntricos 20 202 3398 3 98 33.9 2 339 9 33.
ABSTRACT Objective: To describe the IMPACTO-MR, a Brazilian nationwide intensive care unit platform study focused on the impact of health care-associated infections due to multidrug-resistant bacteria. Methods: We described the IMPACTO-MR platform, its development, criteria for intensive care unit selection, characterization of core data collection, objectives, and future research projects to be held within the platform. Results: The core data were collected using the Epimed Monitor System® and consisted of demographic data, comorbidity data, functional status, clinical scores, admission diagnosis and secondary diagnoses, laboratory, clinical, and microbiological data, and organ support during intensive care unit stay, among others. From October 2019 to December 2020, 33,983 patients from 51 intensive care units were included in the core database. Conclusion: The IMPACTO-MR platform is a nationwide Brazilian intensive care unit clinical database focused on researching the impact of health care-associated infections due to multidrug-resistant bacteria. This platform provides data for individual intensive care unit development and research and multicenter observational and prospective trials. Objective IMPACTOMR, IMPACTOMR IMPACTO MR, MR careassociated associated multidrugresistant multidrug resistant bacteria Methods selection collection objectives Results System status scores diagnoses laboratory stay others 201 2020 33983 33 983 33,98 5 Conclusion trials 20 202 3398 3 98 33,9 2 339 9 33,
2.
COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves
; Ximenez, João Paulo Bianchi
; Seiva, Fábio Rodrigues Ferreira
; Panis, Carolina
; Bezerra, Rafael dos Santos
; Ferrasa, Adriano
; Cecchini, Alessandra Lourenço
; Medeiros, Alexandra Ivo de
; Almeida, Ana Marisa Fusco
; Ramão, Anelisa
; Boldt, Angelica Beate Winter
; Moya, Carla Fredrichsen
; Chin, Chung Man
; Paula, Daniel de
; Rech, Daniel
; Gradia, Daniela Fiori
; Malheiros, Danielle
; Venturini, Danielle
; Tavares, Eliandro Reis
; Carraro, Emerson
; Ribeiro, Enilze Maria de Souza Fonseca
; Pereira, Evani Marques
; Tuon, Felipe Francisco
; Follador, Franciele Aní Caovilla
; Fernandes, Glaura Scantamburlo Alves
; Volpato, Hélito
; Cólus, Ilce Mara de Syllos
; Oliveira, Jaqueline Carvalho de
; Rodrigues, Jean Henrique da Silva
; Santos, Jean Leandro dos
; Visentainer, Jeane Eliete Laguila
; Brandi, Juliana Cristina
; Serpeloni, Juliana Mara
; Bonini, Juliana Sartori
; Oliveira, Karen Brajão de
; Fiorentin, Karine
; Lucio, Léia Carolina
; Faccin-Galhardi, Ligia Carla
; Ferreto, Lirane Elize Defante
; Lioni, Lucy Megumi Yamauchi
; Consolaro, Marcia Edilaine Lopes
; Vicari, Marcelo Ricardo
; Arbex, Marcos Abdo
; Pileggi, Marcos
; Watanabe, Maria Angelica Ehara
; Costa, Maria Antônia Ramos
; Giannini, Maria José S. Mendes
; Amarante, Marla Karine
; Khalil, Najeh Maissar
; Lima Neto, Quirino Alves de
; Herai, Roberto H.
; Guembarovski, Roberta Losi
; Shinsato, Rogério N.
; Mainardes, Rubiana Mara
; Giuliatti, Silvana
; Yamada-Ogatta, Sueli Fumie
; Gerber, Viviane Knuppel de Quadros
; Pavanelli, Wander Rogério
; Silva, Weber Claudio da
; Petzl-Erler, Maria Luiza
; Valente, Valeria
; Soares, Christiane Pienna
; Cavalli, Luciane Regina
; Silva Jr, Wilson Araujo
.
Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.
3.
Influence of genetic regulatory effects modified by environmental immune activation on periapical disease
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Caires, Nely Cristina Medeiros
; Espaladori, Marcela Carvalho
; Tavares, Warley Luciano Fonseca
; Brito, Luciana Carla Neves de
; Vieira, Leda Quercia
; Ribeiro Sobrinho, Antônio Paulino
.
Abstract: The objective of this study was to compare the periradicular responses in endodontic infections among members of two populations: an urban Brazilian population and a non-mixed indigenous population. Samples were collected immediately and 7 days after the cleaning and shaping procedures (after reducing the intracanal microbial load) in an attempt to characterize the expression of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-9, interferon (IFN)-γ, IL-17, IL-10, and the chemokines CXCR4, CCL2/monocyte chemotactic protein (MCP)-1, and CCR6. The endogenous cytokine and chemokine expression levels were analyzed using real-time PCR. Only the urban population showed a significant increase in TNF-α, CCL2/MCP-1, CXCR4, and CCR6 expression following the cleaning and shaping of the root canal system. The IFN-γ levels were increased at the 2nd collection (p < 0.05) in the indigenous population. In turn, a significant increase in IL-10 and IL-17 expression (p < 0.05) was observed after the cleaning and shaping procedures (2nd collection) in both populations. No significant differences in the IL-1β, IL-9, and CCL4 expression levels were observed between the 1st and 2nd collections in both populations. The results demonstrate a cytokine and chemokine expression profile that is specific to each analyzed population. However, immune modulation mediated by IL-10 began on the 7th day after the beginning of the endodontic treatment in both populations.
https://doi.org/10.1590/1807-3107bor-2019.vol33.0109
581 downloads
4.
I Diretriz brasileira de cardio-oncologia pediátrica da Sociedade Brasileira de Cardiologia
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Seber, Adriana
; Miachon, Adriana Siviero
; Tanaka, Ana Cristina Sayuri
; Castro, Ângela Maria Spínola e
; Carvalho, Antônio Carlos
; Petrilli, Antônio Sergio
; Macedo, Carla Renata Donato Pacheco
; Nars, Clarissa Carvalho Fongaro
; Terzian, Claudia Naufel
; Castro Junior, Claudio Galvão de
; Santos, Cleusa Cavalcanti Lapa
; Guerra, Cristina Chaves dos Santos
; Silva, Dafne Cardoso Bourguignon da
; Bassi, Débora Ugayama
; Azeka, Estela
; Feitosa, Fabiana Aragão
; Hamamoto, Fernando
; Szarf, Gilberto
; Lederman, Henrique Manoel
; Rigon Junior, Humberto João
; Jatene, Ieda Biscegli
; Mota, Isabele Coelho Fonseca da
; Perrud, Jeferson Adriano
; Soares Junior, José
; Gutierrez, Julián Arango
; Perin, Juliana Pepe Marinho
; Soares, Juliana dos Santos
; Catani, Liane Hulle
; Tsai, Liliana Yu
; Vianna, Livia Cristina
; Paiva, Marcelo Goulart
; Santos, Marcelo José
; Ishigai, Marcia Marcelino de Souza
; Diógenes, Maria Suely Bezerra
; Alves, Maria Teresa de Seixas
; Piedade, Maria Tereza Castro
; Parreiras, Mariana
; Cypriano, Mônica
; Negrini, Nilce da Silva
; Campos Filho, Orlando
; Figueiredo, Paula Andrade
; Novaes, Paulo Eduardo
; Camargo, Paulo Roberto
; Maia, Priscila dos Santos
; Petrilli, Renata
; Arduini, Rodrigo Genaro
; Gouveia, Roseane Vasconcelos
; Teruya, Suzana Barbosa Miranda
; Moisés, Valdir Ambrosio
; Morais, Vera Lúcia Lins de
.
https://doi.org/10.5935/abc.2013S005
17336 downloads
5.
Educação para a saúde em osteoporose com idosos de um programa universitário: repercussões
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Carvalho, Cecília Maria Resende Gonçalves de
; Fonseca, Carla Cristina Carvalho
; Pedrosa, José Ivo
.
O objetivo do estudo foi análise do conhecimento, concepções e mudanças de comportamento alimentar de idosos universitários em relação à temática osteoporose, antes e após a intervenção educativa. Utilizou-se a estratégia da pesquisa-ação, aplicando-se o questionário a 95 idosos, com idade entre 60 e 86 anos, com ou sem osteoporose. O trabalho tornou patente o desconhecimento dos idosos em informações importantes sobre a doença e dos cuidados que se deve ter para melhor controlar a progressão da perda da massa óssea. Após o período de quatro meses de atividades educativas mais da metade do grupo reportou mudanças na dieta. Enfatiza-se a necessidade de adotar estratégias educativas capazes de informar não só sobre as práticas preventivas ideais da osteoporose, mas também que possam construir uma nova mentalidade e um novo comportamento que sejam importantes para o controle da doença.
The purpose of this study was to analyze knowledge and concepts in relation to osteoporosis and changes in eating habits among elderly university students before and after an educational intervention. An action-based research strategy applied questionnaires to 95 individuals ranging in age from 60 to 86 years, with or without osteoporosis. The work showed an obvious lack of knowledge concerning important information about the disease and measures needed to better control progressive loss of bone mass. After four months of educational activities, more than half of the group had reported dietary changes. We emphasize the need to adopt educational strategies not only to inform on ideal preventive practices for osteoporosis but also to build a new mindset and behavior, which are important to control this condition.
15706 downloads
Cited 2 times in SciELO
6.
Educação para a saúde em osteoporose com idosos de um programa universitário: repercussões
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Carvalho, Cecília Maria Resende Gonçalves de
; Fonseca, Carla Cristina Carvalho
; Pedrosa, José Ivo
.
O objetivo do estudo foi análise do conhecimento, concepções e mudanças de comportamento alimentar de idosos universitários em relação à temática osteoporose, antes e após a intervenção educativa. Utilizou-se a estratégia da pesquisa-ação, aplicando-se o questionário a 95 idosos, com idade entre 60 e 86 anos, com ou sem osteoporose. O trabalho tornou patente o desconhecimento dos idosos em informações importantes sobre a doença e dos cuidados que se deve ter para melhor controlar a progressão da perda da massa óssea. Após o período de quatro meses de atividades educativas mais da metade do grupo reportou mudanças na dieta. Enfatiza-se a necessidade de adotar estratégias educativas capazes de informar não só sobre as práticas preventivas ideais da osteoporose, mas também que possam construir uma nova mentalidade e um novo comportamento que sejam importantes para o controle da doença.
The purpose of this study was to analyze knowledge and concepts in relation to osteoporosis and changes in eating habits among elderly university students before and after an educational intervention. An action-based research strategy applied questionnaires to 95 individuals ranging in age from 60 to 86 years, with or without osteoporosis. The work showed an obvious lack of knowledge concerning important information about the disease and measures needed to better control progressive loss of bone mass. After four months of educational activities, more than half of the group had reported dietary changes. We emphasize the need to adopt educational strategies not only to inform on ideal preventive practices for osteoporosis but also to build a new mindset and behavior, which are important to control this condition.
14007 downloads
Cited 2 times in SciELO
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