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ABSTRACT Over-the-counter medications (OTC), also known as non-prescription drugs can be dispensed without a prescription. This study aimed to analyze the pharmacological profile, risk, and quality of evidence of OTC medications registered in Brazil. The databases of ANVISA and Micromedex synthesis were consulted. The indications for use were classified according to CIAP, the medications according to ATC, and the quality of evidence according to the GRADE method. A total of 188 OTC medications were identified, comprising 376 presentations. The groups related to the digestive tract and respiratory system had the highest number of drugs, each accounting for 19%. Overall, 61% of the drugs were classified as having high or moderate evidence, and 39% as low, very low, or lacking evidence. Despite the prevalence of higher-quality evidence, restrictions need to be highlighted, as approximately 55% of the drugs have a weak recommendation, 67% may not be used by children under the age of 6, 95% lack reliable safety information during pregnancy, and 87% lack clear information regarding use during lactation. Further research on the topic, supported self-care policies, and monitoring seem essential to better understand the risks and benefits associated with OTC medications, thus ensuring a safer and evidence-based clinical practice.

RESUMO Os Medicamentos Isentos de Prescrição (MIP) ou de venda livre podem ser fornecidos sem exigência de receita. Este estudo objetivou analisar o perfil farmacológico, risco e qualidade da evidência dos MIP registrados no Brasil. Foram consultadas as bases de dados da Anvisa e a base de síntese Micromedex. As indicações de uso foram classificadas segundo Ciap, os medicamentos segundo ATC e a qualidade da evidência segundo método Grade. Foram identificados 188 MIP, com 376 apresentações. Os grupos de trato alimentar e respiratório tiveram os maiores números de fármacos, com 19% cada. No geral, 61% dos fármacos foram classificados como evidência alta ou moderada e 39% como baixa, muito baixa ou sem evidência. Apesar da prevalência de maior qualidade de evidência, as restrições precisam ser evidenciadas, pois cerca de 55% dos fármacos possuem força de recomendação fraca, 67% não podem ser utilizados por crianças menores de 6 anos, 95% não possuem informações confiáveis de segurança na gestação e 87% não possuem informações de uso na lactação. Mais pesquisas sobre o tema, políticas de autocuidado apoiado e monitoramento parecem essenciais para melhor compreender os riscos e benefícios associados aos MIP, garantindo uma prática clínica mais segura e baseada em evidências.

https://doi.org/10.1590/2358-289820241438939p

Mapeamento das evidências de medicamentos isentos de prescrição registrados no Brasil: análise comparativa segundo método Grade Brasil
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Laismann, Nara Amanda

; Calado, Gustavo Pereira

; Barbosa, Ana Paula de Oliveira

; Lima, Rodrigo Fonseca

; Santana, Rafael Santos

Saúde em Debate

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oct 2024, Volume 48 N. 143 elocation e8939

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.1590/2358-289820241438939p

Desenvolvimento de um design de telessimulação para o suporte básico de vida
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Bernardinelli, Fabiana Cristina Pires

; Amorim, Gustavo Correa de

; Nascimento, Juliana da Silva Garcia

; Fonseca, Luciana Mara Monti

; Domingues, Tânia Arena Moreira

; Condeles, Paulo César

; Chavaglia, Suzel Regina Ribeiro

Acta Paulista de Enfermagem

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2024, Volume 37 elocation eAPE00021

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen Objetivo Elaborar y validar un diseño de telesimulación sincrónica y observacional de enfermería para la atención de acuerdo con el protocolo de soporte vital básico intrahospitalario en adultos. Métodos Estudio metodológico basado en las fases del procedimiento teórico realizado por medio de una scoping review, fase empírica llevada cabo a través de la validación de contenido del diseño telesimulado y fase analítica en la que se adoptó el índice de validez de contenido. Resultados Se elaboró un diseño para la atención de acuerdo con el protocolo de soporte vital básico que atravesó seis etapas: planificación, preparación, participación, teledebriefing, evaluación y feedback y aprendizaje adicional, con un Índice de Validez de Contenido de 0,96. Conclusión El diseño elaborado fue considerado válido en contenido para planificar y ejecutar la telesimulación por parte de enfermeros y además puede adaptarse a otros contextos educativos. adultos review etapas planificación preparación participación teledebriefing adicional 096 0 96 0,96 educativos 09 9 0,9 0,

Resumo Objetivo Construir e validar um design de telessimulação síncrona e observacional em enfermagem para o atendimento segundo o protocolo de suporte básico de vida intra-hospitalar no adulto. Métodos Estudo metodológico baseado nas fases do procedimento teórico realizado por meio de uma scoping review; fase empírica desenvolvida através da validação de conteúdo do design telessimulado e fase analítica em que adotou-se o índice de validade de conteúdo. Resultados Construiu-se um design para o atendimento segundo o protocolo de suporte básico de vida percorrendo seis etapas: o planejamento, preparação, participação, teledebriefing, avaliação e feedback e a aprendizagem adicional, com Índice de Validade de Conteúdo de 0,96. Conclusão O design desenvolvido foi considerado válido em conteúdo para planejar e executar a telessimulação pela enfermagem e ainda ser adaptado a outros contextos educacionais. intrahospitalar intra hospitalar adulto review adotouse adotou se Construiuse Construiu etapas planejamento preparação participação teledebriefing adicional 096 0 96 0,96 educacionais 09 9 0,9 0,

Abstract Objective To construct and validate a synchronous and observational telesimulation design in nursing for care according to in-hospital basic life support protocol for adults. Methods A methodological study based on the phases of the theoretical procedure carried out through a scoping review; empirical phase developed through the telesimulated design content validity and analytical phase in which the content validity index was adopted. Results A care design was constructed according to the basic life support protocol, going through six steps: planning, preparation, participation, teledebriefing, assessment and feedback and additional learning, with a Content Validity Index of 0.96. Conclusion The developed design was considered valid in content to plan and execute telesimulation by nursing and still be adapted to other educational contexts. inhospital hospital adults review adopted steps planning preparation participation teledebriefing learning 096 0 96 0.96 contexts 09 9 0.9 0.

https://doi.org/10.37689/acta-ape/2024ao0000021

Tendência Temporal no Implante Percutâneo de Bioprótese Aórtica: Análise de 10 Anos do Registro TAVIDOR Aórtica 1
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Esteves, Vinicius

; Andrade, Pedro Beraldo de

; Zukowski, Cleverson Neves

; Araujo, Edmur

; Bezerra, Cristiano Guedes

; Oliveira, Adriano Dourado

; Melo, Eduardo Pessoa de

; Gama, Gustavo

; Cantarelli, Rodrigo

; Mattos, Luiz Alberto Piva e

; Tedeschi, Angelo

; Loures, Vitor Alves

; Vahle, Vitor

; Silva, Guilherme Barreto Gameiro

; Rati, Miguel Antonio Neves

; Lopes, Augusto Celso

; Fé Filho, Nilson de Moura

; Alves, Gustavo

; Tavares Filho, Sérgio Costa

; Kreimer, Sergio

; Tebet, Marden

; Maia, Felipe

; Oliveira, Maurício Sales de

; Fonseca, Alberto

; Camiletti, Angelina

; Albuquerque, Denilson Campos de

; Souza, Olga Ferreira de

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 5 elocation e20230467

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Background Transcatheter aortic valve implantation (TAVI) has established itself as the preferential strategy to approach severe aortic stenosis. Information on procedural improvements and nationwide results obtained with the technique throughout the past decade are unknown. Objectives To assess the temporal variation of the demographic profile, procedural characteristics, and in-hospital outcomes of patients undergoing TAVI procedures at the Rede D’Or São Luiz. Methods Observational registry comprising 29 national institutions, comparing the characteristics of the TAVI procedures performed from 2012 to 2017 (Group 1) to those performed from 2018 to 2023 (Group 2). The statistical significance level adopted was p < 0.05. Results This study assessed 661 patients, 95 in Group 1 and 566 in Group 2, with a mean age of 81.1 years. Group 1 patients had a higher prevalence of New York Heart Association functional class III or IV and STS risk score > 8%. In addition, they more often underwent general anesthesia, transesophageal echocardiographic monitoring, and access through femoral dissection. Group 2 patients had a higher success rate of the TAVI procedure (95.4% versus 89.5%; p = 0.018), lower mortality (3.9% versus 11.6%; p = 0.004), and less often needed permanent pacemaker implantation (8.5% versus 17.9%; p = 0.008). Conclusions The 10-year temporal trends analysis of the TAVIDOR Registry shows a reduction in patients’ clinical complexity over time. Furthermore, the advance to minimalistic implantation techniques, added to the technological evolution of the devices, may have contributed to the favorable outcomes observed among those whose implantation occurred in the last 5 years studied. (TAVI stenosis unknown profile inhospital hospital DOr D Or Luiz institutions 201 202 2. . 2) 005 0 05 0.05 66 9 56 811 81 81. 8 8% addition anesthesia monitoring dissection 95.4% 954 4 (95.4 89.5% 895 89 0.018, 0018 0.018 , 018 0.018) 3.9% 39 3 (3.9 11.6% 116 11 6 0.004, 0004 0.004 004 0.004) 8.5% 85 (8.5 17.9% 179 17 0.008. 0008 0.008 008 0.008) 10year year 10 time Furthermore techniques devices studied 20 00 0.0 95.4 (95. 89.5 001 0.01 01 3.9 (3. 11.6 000 0.00 8.5 (8. 17.9 0. 95. (95 89. 3. (3 11. 8. (8 17. (9 (

Resumo Fundamento O implante percutâneo de bioprótese valvar aórtica (TAVI) consolidou-se como opção terapêutica da estenose aórtica de grau importante. Dados sobre as características evolutivas dos procedimentos e dos resultados obtidos com a técnica ao longo da última década, em escala nacional, são desconhecidos. Objetivos Analisar a tendência temporal referente ao perfil demográfico, características dos procedimentos e desfechos hospitalares de pacientes submetidos a TAVI na Rede D’Or São Luiz. Métodos Registro observacional envolvendo 29 instituições nacionais. Comparou-se características dos procedimentos realizados de 2012 a 2017 (Grupo 1) e de 2018 a 2023 (Grupo 2). Foram considerados significantes os resultados com valor de p < 0,05. Resultados Foram analisados 661 casos, 95 pertencentes ao Grupo 1 e 566 ao Grupo 2. A média de idade foi 81,1 anos. Observou-se no Grupo 1 maior prevalência de pacientes em classe funcional III ou IV e escore de risco > 8%. Foi mais frequente o emprego de anestesia geral, monitorização ecocardiográfica transesofágica e via de acesso por dissecção. Maior taxa de sucesso do procedimento (95,4% versus 89,5%; p = 0,018) foi aferida em implantes efetivados a partir de 2018, assim como menor mortalidade (3,9% versus 11,6%; p = 0,004) e necessidade de marcapasso definitivo (8,5% versus 17,9%; p = 0,008). Conclusões A análise temporal de 10 anos do Registro TAVIDOR demonstra uma queda na complexidade clínica dos pacientes. Além disso, o avanço para técnicas de implante minimalistas, somadas à evolução tecnológica dos dispositivos, podem ter contribuído para desfechos favoráveis dentre aqueles cujo implante ocorreu no último quinquênio. (TAVI consolidouse consolidou se importante década nacional desconhecidos demográfico DOr D Or Luiz 2 nacionais Comparouse Comparou 201 202 . 2) 005 0 05 0,05 66 casos 9 56 811 81 81, Observouse Observou 8 8% geral dissecção 95,4% 954 4 (95,4 89,5% 895 89 5 0,018 0018 018 3,9% 39 3 (3,9 11,6% 116 11 6 0,004 0004 004 8,5% 85 (8,5 17,9% 179 17 0,008. 0008 0,008 008 0,008) disso minimalistas dispositivos quinquênio 20 00 0,0 95,4 (95, 89,5 0,01 001 01 3,9 (3, 11,6 0,00 000 8,5 (8, 17,9 0, 95, (95 89, 3, (3 11, 8, (8 17, (9 (

https://doi.org/10.36660/abc.20230467

Mediação literária nas bibliotecas universitárias federais brasileiras
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Tanus, Gabrielle Francinne de Souza Carvalho

; Fonseca, Aline Jardim da

; Tanus, Gustavo

Em Questão

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2024, Volume 30 elocation e-137859

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract University libraries are social institutions linked to universities, which have a social responsibility not only to science but to society as a whole. Given this, there are countless challenges and problems posed to both universities and libraries, such as, for example, the low reading rates of the Brazilian people. After all, does the university library have anything to do with this? We believe so, which is why literary mediation is the object of study in this article, which aims to observe the existence of projects on the websites of central libraries, linked to Brazilian federal universities. The research is considered descriptive and documentary in nature. Literary mediation involves literature, readers, and mediators who may or may not be librarians, in a complex process of collective elaboration of meanings and their forms of sharing. The results from the research demonstrate a reduced number of projects, the most powerful for the implementation of literary mediations being reading clubs and the creation of specific spaces. Therefore, literary mediations are an action to be developed or supported by university libraries so that the social, cultural, and formative function of subjects can be strengthened by public institutions that provide services to the academic community, and in general. whole example people all article nature literature readers librarians sharing spaces Therefore cultural community general

Resumo As bibliotecas universitárias são instituições sociais vinculadas às universidades, as quais tem uma responsabilidade social não apenas com a ciência, mas com a sociedade como um todo. Diante disso, são inúmeros os desafios e problemas que são postos a ambas, universidades e bibliotecas, como, por exemplo, os baixos índices de leitura do povo brasileiro. Afinal, será que a biblioteca universitária tem alguma coisa a ver com isso? Acreditamos que sim, por isso, a mediação literária é objeto de estudo neste artigo que visa observar a existência de projetos nos sites das bibliotecas centrais, vinculadas as universidades federais brasileiras. A pesquisa é considerada descritiva e de cunho documental. A mediação literária, envolve a literatura, os leitores e mediadores que podem ser os bibliotecários ou não, num processo complexo de elaboração coletiva de significados e suas formas de partilha. Os resultados oriundos da pesquisa demonstram uma quantidade reduzida de projetos, sendo o mais potente para as concretizações das mediações literárias os clubes de leituras. Sendo, portanto, as mediações literárias uma ação a ser desenvolvida ou apoiada pelas bibliotecas universitárias a fim de que a função social, cultural e formativa dos sujeitos, possa ser fortalecida pelas instituições públicas que prestam serviços a comunidade acadêmica, e, em geral. ciência todo disso ambas exemplo brasileiro Afinal isso sim centrais brasileiras documental literatura partilha leituras Sendo portanto sujeitos acadêmica geral

https://doi.org/10.1590/1808-5245.30.137859

Seaweed extract-based fertilizer and water stress on potato crops extractbased extract based
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Nunes, Gustavo Fonseca

; Moreira, Leticia Gonçalves

; Diniz, Nadia Mendes

; Jacinto, Ana Carolina Pires

; Prado, Jair Rocha do

; Charlo, Hamilton César de Oliveira

; Castoldi, Renata

Ciência e Agrotecnologia

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2024, Volume 48 elocation e018523

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

ABSTRACT Seaweed extract-based fertilizers are applied to mitigate the effects of stress on plants. In this study, we evaluated the effects of different concentrations of seaweed extract-based fertilizer and different irrigation depths on potato crops. The Ágata cultivar and the Markies cultivar were used to conduct two experiments simultaneously. A 4 × 4 experimental design was used, with four doses of seaweed extract-based fertilizer (0, 0.5, 1.0, and 4.0 L ha-1) and four irrigation depths (50%, 75%, 100%, and 125% of crop evapotranspiration); each treatment had three replicates. Leaves were collected 67 days after emergence to analyze macronutrients and micronutrients; additionally, the number of stems per plant and physiological variables were assessed. After harvesting, the number and weight of tubers in different classes were recorded. The differences in parameters among treatment groups were determined by analysis of variance using the F-test, and regression analysis was performed when a significant difference was recorded. The results showed that the contents of potassium, phosphorus, magnesium, and calcium in the leaves of the Ágata cultivar were below the optimal levels for the crop, irrespective of the irrigation level and the dose of seaweed extract-based fertilizer applied. The highest irrigation depths at 100% and 125% of crop evapotranspiration were associated with an increase in the number and weight of the large tubers of the Ágata and Markies cultivars. extractbased extract based plants study crops simultaneously 0, 0 (0 05 5 0.5 10 1 1.0 40 4. ha1 ha ha-1 50%, 50 (50% 75 75% 100 125 evapotranspiration) replicates 6 micronutrients additionally assessed harvesting recorded Ftest, Ftest F test, test F-test potassium phosphorus magnesium cultivars ( 0. 1. ha- 50% (50 7 12 (5

RESUMO Para mitigar os efeitos do estresse nas plantas, têm sido aplicados fertilizantes foliares à base de extrato de algas marinhas. Objetivou-se avaliar os efeitos de diferentes concentrações de fertilizante à base de extrato de algas marinhas e lâminas de irrigação na cultura da batata. Dois experimentos foram conduzidos simultaneamente, um com a cultivar Ágata e outro com a cultivar Markies. O delineamento experimental utilizado foi 4 × 4, com quatro doses de fertilizante à base de extrato de algas marinhas (0; 0,5; 1,0 e 4,0 L ha-1) e quatro lâminas de irrigação (50%, 75%, 100% e 125% da evapotranspiração da cultura), com três repetições. Aos 67 dias após a emergência foram coletadas folhas para análise de macro e micronutrientes e, também avaliaram-se: número de hastes por planta e variáveis fisiológicas. Após a colheita, avaliaram-se: número e peso dos tubérculos de diferentes classes. Os dados foram submetidos à análise de variância por meio do teste F e análise de regressão foi realizada quando houve diferença significativa. Os teores de potássio, fósforo, magnésio e cálcio nas folhas da cultivar Ágata ficaram abaixo dos níveis ótimos para a cultura, independente do nível de irrigação e da da dose de fertilizante aplicado. O fertilizante reduziu os efeitos do estresse hídrico, aumentando a eficiência fotoquímica das plantas de batata Markies. As maiores lâminas de irrigação em 100% e 125% da evapotranspiração da cultura levaram ao aumento do número e peso de tubérculos grandes para as cultivares Ágata e Markies. Objetivouse Objetivou se simultaneamente Markies 0 (0 0,5 05 5 10 1 1, 40 ha1 ha ha-1 50%, 50 (50% 75 75% 100 125 , cultura) repetições 6 avaliaramse avaliaram avaliaram-se fisiológicas colheita classes significativa potássio fósforo aplicado hídrico ( 0, ha- 50% (50 7 12 (5

https://doi.org/10.1590/1413-7054202448018523

Relative age effect on muscle power in Brazilian youth: a population study youth
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Bergmann, Gabriel Gustavo

; Mello, Júlio Brugnara

; Gaya, Adroaldo Cezar Araujo

; Fonseca, Fabiano de Souza

; Silva, Amanda Franco da

; Ferreira, Gustavo Dias

; Pinheiro, Eraldo dos Santos

Revista Brasileira de Cineantropometria & Desempenho Humano

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2024, Volume 26 elocation e98244

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract This study aimed to examine the relative age effect on muscle power in a large sample of Brazilian children and adolescents. The sample consisted of 87,766 girls and boys aged 7-16 years, data collected in repeated cross-sectional surveillance carried out since 1999. The participants were grouped into four age subgroups within each chronological age based on birthdates. Upper and lower limbs muscle power were assessed using the 2-Kg medicine ball throw and horizontal jump tests, respectively. The normative distribution of physical fitness components was used for classification. The results showed a significant association between relative age and normative classification of muscle power. Among boys, there was a sequential increase in the frequency of individuals classified as “very good/excellent” as the relative age increased. A similar trend was observed among girls. The findings provided evidence of a relative age effect on muscle power in Brazilian children and adolescents. These findings have implications for the organization of structured physical activities and sports, as early-born individuals may have an advantage in performance. Further research is needed to explore the underlying mechanisms and potential interventions to mitigate the relative age effect and promote equal opportunities for all youth in physical activities and sports. adolescents 87766 87 766 87,76 716 7 16 7-1 years crosssectional cross sectional 1999 birthdates 2Kg Kg 2 tests respectively very good/excellent goodexcellent good excellent increased sports earlyborn early born performance 8776 8 76 87,7 71 1 7- 199 877 87, 19

Resumo Este estudo teve como objetivo examinar o efeito da idade relativa na potência muscular em crianças e adolescentes brasileiros. A amostra foi composta por 87.766 meninas e meninos com idades entre 7 e 16 anos. Os participantes foram agrupados em quatro subgrupos etários dentro de cada idade cronológica tendo como base as datas de nascimento e da coleta dos dados. A potência muscular dos membros superiores e inferiores foi avaliada por meio dos testes de arremesso de medicine ball de 2 kg, e salto horizontal, respectivamente. A distribuição normativa (fraco; razoável; bom; muito bom; excelente) dos dois testes de potência foi utilizada para a classificação. Os resultados mostraram associação significativa entre os subgrupos etários e a classificação normativa da potência muscular. Entre os meninos, houve aumento na frequência de indivíduos classificados como “muito bom/excelente” à medida que a idade relativa aumentava. Uma tendência semelhante foi observada entre as meninas. Os achados forneceram evidências do efeito de idade relativa na potência muscular de crianças e adolescentes brasileiros. Esses resultados têm implicações práticas na organização de atividades físicas estruturadas e esportes em diferentes contextos, pois indivíduos nascidos mais cedo podem ter vantagem no desempenho em tarefas que exijam potência muscular. Mais pesquisas são necessárias para explorar os mecanismos subjacentes e intervenções que possam mitigar o efeito de idade relativa e promover oportunidades iguais para todas as crianças e adolescentes nas atividades físicas e esportes. brasileiros 87766 87 766 87.76 1 anos dados kg horizontal respectivamente fraco (fraco razoável bom excelente bom/excelente bomexcelente aumentava contextos 8776 8 76 87.7 877 87.

https://doi.org/10.1590/1980-0037.2024v26e98244

Influence of zoledronic acid and low-intensity laser on collagen fibers during the bone repair process lowintensity low intensity
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Aguilar, Paola

; Fonseca, Angélica Cristina

; Garlet, Gustavo Pompermaier

; Gulinelli, Jéssica Lemos

; Santos, Pâmela Letícia

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e393724

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate collagen fibers during the bone repair process in critical defects created in the tibias of rats, treated with zoledronic acid (AZ) associated with low-level laser therapy (LLLT). Methods: Ten rats were distributed according to treatment: group 1) saline solution; group 2) LLLT; group 3) AZ; group 4) AZ and LLLT. AZ was administered at the dose of 0.035 mg/kg at fortnightly intervals over eight weeks. Next, 2-mm bone defects were created in the tibias of all animals. The bone defects in groups 2 and 4 were irradiated LLLT in the immediate postoperative period. After periods 14 and 28 of application, the animals were euthanized, and birefringence analysis was performed. Results: Approximately 90% of the total area was occupied by collagen fibers within the red color spectrum, this area being statistically larger in relation to the area occupied by collagen fibers within the green and yellow spectrum, in the four groups. Over the 14-day period, there was no statistically significant difference between the groups. In the 28-day period, group 2 (14.02 ± 15.9%) was superior in quantifying green birefringent fibers compared to group 1 (3.06 ± 3.24%), with p = 0.009. Conclusions: LLLT associated with ZA is effective in stimulating the neoformation of collagen fibers. The LLLT group without the association with ZA showed a greater amount of immature and less organized matrix over a period of 28 days. Purpose (AZ lowlevel low level . (LLLT) Methods treatment solution 3 0035 0 035 0.03 mgkg mg kg weeks Next 2mm mm application euthanized performed Results 90 spectrum 14day day 28day 14.02 1402 02 (14.0 15.9% 159 15 9 3.06 306 06 (3.0 3.24%, 324 3.24% , 24 3.24%) 0009 009 0.009 Conclusions days (LLLT 003 03 0.0 14.0 140 (14. 15.9 3.0 30 (3. 32 3.24 000 00 0.00 0. 14. (14 15. 3. (3 3.2 (1 (

https://doi.org/10.1590/acb393724

Impact of streptozotocin-induced diabetes on experimental masseter pain in rats streptozotocininduced streptozotocin induced
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COSTA, Yuri Martins

; HERCULIANI, Clarissa Carolina Fernandes

; SOARES, Flávia Fonseca Carvalho

; AZEVEDO, Michelle de Campos Soriani

; CONTI, Paulo César Rodrigues

; DIONÍSIO, Thiago José

; OLIVEIRA, Gabriela de Moraes

; FARIA, Flávio Augusto Cardoso de

; SANTOS, Carlos Ferreira

; GARLET, Gustavo Pompermaier

; BONJARDIM, Leonardo Rigoldi

Brazilian Oral Research

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2024, Volume 38 elocation e073

Abstract: En | Text: En | PDF: En

Abstract This study aimed to assess the influence of streptozotocin (STZ)-induced diabetes on the nociceptive behavior evoked by the injection of hypertonic saline (HS) into the masseter muscle of rats. Forty male rats were equally divided into four groups: a) isotonic saline control, which received 0.9% isotonic saline (IS), (Ctrl-IS); b) hypertonic saline control, which received 5% HS (Ctrl-HS); c) STZ-induced diabetic, which received IS, (STZ-IS); d) STZ-induced diabetic, which received HS (STZ-HS). Experimental diabetes was induced by a single intraperitoneal injection of STZ at dose of 60 mg/kg dissolved in 0.1 M citrate buffer, and 100 μL of HS or IS were injected into the left masseter to measure the nociceptive behavior. Later on, muscle RNA was extracted to measure the relative expression of the following cytokines: cyclooxygenase-2 (COX-2), tumor necrosis factor (TNF-α), and interleukins (IL)-1β, -2, -6, and -10. One-way analysis of variance (ANOVA) was applied to the data (p < 0.050). We observed a main effect of group on the nociceptive response (ANOVA: F = 11.60, p < 0.001), where the Ctrl-HS group presented the highest response (p < 0.001). However, nociceptive response was similar among the Ctrl-IS, STZ-IS, and STZ-HS group (p > 0.050). In addition, the highest relative gene expression of TNF-α and IL-6 was found in the masseter of control rats following experimental muscle pain (p < 0.050). In conclusion, the loss of somatosensory function can be observed in deep orofacial tissues of STZ-induced diabetic rats. STZinduced (HS groups 09 0 9 0.9 , (IS) CtrlIS Ctrl (Ctrl-IS) b 5 CtrlHS (Ctrl-HS) c STZIS (STZ-IS) d STZHS. STZHS . (STZ-HS) 6 mgkg mg kg 01 1 0. buffer 10 cytokines cyclooxygenase2 cyclooxygenase 2 cyclooxygenase- COX2, COX2 COX (COX-2) TNFα, TNFα TNF α (TNF-α) IL1β, IL1β ILβ IL 1β, 1β β (IL)-1β 2, -2 6, -6 10. -10 Oneway One way ANOVA (ANOVA 0.050. 0050 0.050 050 0.050) 1160 11 11.60 0.001, 0001 0.001 001 0.001) 0.001. However CtrlIS, Ctrl-IS STZIS, STZ-IS addition IL6 IL- conclusion (IS (Ctrl-IS (Ctrl-HS (STZ-IS (STZ-HS (COX-2 (TNF-α - -1 005 0.05 05 116 11.6 000 0.00 00 (COX- 0.0 11. (COX

https://doi.org/10.1590/1807-3107bor-2024.vol38.0073

10.

Nutritive value of adding dried Cratylia argentea leaves to the feed of growing rabbits
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Camara, Bárbara Romélia Batista

; Fonseca, Leonardo da Silva

; Luciano, Adriano Pedreira

; Martins, Paulo Gustavo Macedo de Almeida

; Almeida, Alexander Alexandre de

; Valentim, Jean Kaique

; Naves, Luciana de Paula

; Matrangolo, Walter José Rodrigues

Ciência Animal Brasileira

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2024, Volume 25 elocation e-77004

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Nutrition in rabbit farming accounts for about 70% of all costs; in this sense, C. argentea is an excellent alternative as a feed, due to its bromatological composition. Our goal is to evaluate the nutritional value of diets formulated with the dried leaves of C. argentea to feed growing rabbits. Twenty-eight white rabbits of the New Zealand breed, 55 days old, of both sexes, were used. Two treatments (n = 14, 7 males, and 7 females) were evaluated in a randomized block experimental design in a 2 x 2 factorial scheme. The control diet (CTRL) was formulated to meet the nutritional requirements of growing rabbits, and the test diet (DRY) was obtained by replacing 20% of the CTRL diet with dried leaves of C. argentea. The experimental period was comprised of 11 days, with seven days of adaptation and four days of total feces collection. The average daily gain, dry matter intake, feed conversion, and final body weight were not affected by replacing the CTRL diet with the dried leaves of C. argentea. The coefficient of dry matter digestibility showed better results in CTRL rabbits (female: 72.19%, male: 72.48%). Rabbits fed with the CTRL diet exhibited a higher consumption of crude protein compared to those fed with the DRY diet, however, these rabbits showed higher elimination and lower retention of crude protein. It is concluded that C. argentea presents values of 1,400.67 kcal per kg of dry matter, digestible energy, and 3.34% digestible protein per kg of dry matter. 70 costs sense C composition Twentyeight Twenty eight breed 5 old sexes used n 14 males females scheme (CTRL (DRY 20 1 collection gain intake conversion female (female 7219 72 19 72.19% male 72.48%. 7248 72.48% . 48 72.48%) however 140067 400 67 1,400.6 energy 334 3 34 3.34 721 72.19 724 72.48 4 14006 40 6 1,400. 33 3.3 72.1 72.4 1400 1,400 3. 72. 140 1,40 1,4 1,

Resumo A nutrição na criação de coelhos representa cerca de 70% de todos os custos; nesse sentido, a Cratylia argentea é uma excelente alternativa como alimento devido à sua composição bromatológica. Nosso objetivo foi avaliar o valor nutricional de dietas formuladas com folhas secas de C. argentea na alimentação de coelhos em crescimento. Foram utilizados 28 coelhos brancos da raça Nova Zelândia, com 55 dias de idade, de ambos os sexos. Dois tratamentos (n = 14, 7 machos e 7 fêmeas) foram avaliados em delineamento experimental de blocos casualizados em esquema fatorial 2 x 2. A dieta controle (CTRL) foi formulada para atender às exigências nutricionais de coelhos em crescimento, e a dieta teste (DRY) foi obtida substituindo 20% da dieta CTRL por folhas secas de C. argentea. O período experimental compreendeu 11 dias, sendo sete dias de adaptação e quatro dias de coleta total de fezes. O ganho médio diário, o consumo de matéria seca, a conversão alimentar e o peso corporal final não foram afetados pela substituição da dieta CTRL por folhas secas de C. argentea. O coeficiente de digestibilidade da matéria seca apresentou melhores resultados nos coelhos CTRL (Fêmea: 72,19%, Macho: 72,48%). Coelhos alimentados com a dieta CTRL apresentaram maior consumo de proteína bruta do que os alimentados com a dieta DRY, porém esses coelhos tiveram maior excreção e menor retenção de proteína bruta. Conclui-se que Cratylia argentea apresenta valores de 1.400,67 kcal de energia digestível por kg de matéria seca e 3,34% de proteína digestível por kg de matéria seca. 70 custos sentido bromatológica C crescimento Zelândia 5 idade sexos n 14 fêmeas (CTRL DRY (DRY 20 1 fezes diário Fêmea (Fêmea 7219 72 19 72,19% Macho 72,48%. 7248 72,48% . 48 72,48%) Concluise Conclui se 140067 400 67 1.400,6 334 3 34 3,34 721 72,19 724 72,48 4 14006 40 6 1.400, 33 3,3 72,1 72,4 1400 1.400 3, 72, 140 1.40 1.4 1.

https://doi.org/10.1590/1809-6891v25e-77004e

11.

Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat’s skin topically bagging rats rat s
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Frezza, Bárbara Di Martino

; Rahal, Sheila Canevese

; Santos, Ivan Felismino Charas dos

; Silva, Bruna Martins da

; Silva Junior, José Ivaldo de Siqueira

; Ferreira, Gustavo Manea

; Vettorato, Michel de Campos

; Fogaça, Jéssica Leite

; Tsunemi, Miriam Harumi

; Fonseca-Alves, Carlos Eduardo

; Pellizzon, Claudia Helena

; Rosa, Vinicius dos Santos

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e397024

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: This study aimed to evaluate the effects of ozone therapy applied topically and/or by bagging on the healing of clean wounds induced in rat’s skin. Methods: One hundred and twenty male rats of about 16 weeks old was divided into five groups: G1) saline solution (0.9%); G2) sunflower oil; G3) ozonated sunflower oil; G4) ozone bagging; G5) association of ozonated sunflower oil and ozone bagging. The wounds were evaluated through macroscopic, morphometric, histopathologic, and tensile strength analyses. Results: Analysis among groups showed a lower percentage of wound contraction in G1 compared to G4 only in M7D. The tensile strength of the wounds showed differences among groups in the seventh (M7D) and the 14th (M14D) postoperative day, and among time points in G1 (M14D > M7D). The elongation of the wounds showed differences in G3 (M7D > M14D). Histological evaluation of the wounds showed significant change in bleeding, mixed to mononuclear infiltrate, congestion, and tissue disorganization for tissue organization between groups and time points. Conclusions: Ozone therapy applied topically and/or by bagging was not deleterious to the healing of clean wounds induced in rat’s skin, but ozone bagging showed the best contribution to the healing process. Purpose andor or rat s skin Methods 1 G 0.9% 09 0 9 (0.9%) G2 G5 macroscopic morphometric histopathologic analyses Results M7D MD M D th M14D day . M7D) M14D. M14D) bleeding infiltrate congestion Conclusions process 0.9 (0.9% 0. (0.9 (0. (0 (

https://doi.org/10.1590/acb397024

12.

Longitudinal data collection in pediatric and adult patients with 5q spinal muscular atrophy in Latin America: LATAM RegistrAME study - a clinical registry study protocol q America
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Batista, Elice Carneiro

; Zanoteli, Edmar

; Monfardini, Frederico

; Santos, Gustavo Prado dos

; Silva, Gisele Sampaio

; Berwanger, Otávio

; Rizzo, Luiz Vicente

; Fonseca, Henrique Andrade Rodrigues da

einstein (São Paulo)

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2024, Volume 22 elocation eAE1133

Abstract: En | Text: En | PDF: En

ABSTRACT Spinal muscular atrophy is a rare hereditary neurodegenerative disease characterized by progressive motor neuron loss. The most common form of SMA is linked to 5q (5q-SMA) and is classified into subtypes according to the age of onset and maximum motor function achieved. The severity ranges from progressive infantile paralysis and premature death (type 1) to limited motor neuron loss in adults (type 4). The LATAM RegistrAME protocol is an observational, retrospective, prospective international multicenter clinical registry study involving Latin Americans. We will include 5q-SMA patients across all age groups, from pediatric to adult, to describe their clinical characteristics and disease progression. The protocol will use an international clinical research form based on the Treat Neuromuscular Disease Global Academic Network (TREAT-NMD), which focuses on advancing research on neuromuscular disorders in patients with spinal muscular atrophy. The study will include six countries in Latin America, sampling a total of 415 patients with SMA and 5q-SMA types 1, 2, 3, and 4 of all ages and both sexes who have genetically confirmed 5q-SMA. The mean follow-up period was 24 months. The primary outcomes will be the description of general clinical characteristics, access to medications capable of modifying the course of the disease, functional assessments, motor milestones, and ventilatory support. This study will provide insights into 5q spinal muscular atrophy patients in Latin America to better understand their clinical characteristics, use of medications, and outcomes while supporting further clinical management protocols and clinical trials. ClinicalTrials.gov Identifier: NCT05475691. q 5qSMA qSMA (5q-SMA achieved type 1 4. . 4) observational retrospective Americans groups adult progression TREATNMD, TREATNMD TREAT NMD , (TREAT-NMD) 41 2 3 5qSMA. SMA. followup follow up months assessments milestones support trials ClinicalTrialsgov ClinicalTrials gov Identifier NCT05475691 NCT (TREAT-NMD NCT0547569 NCT054756 NCT05475 NCT0547 NCT054 NCT05 NCT0

https://doi.org/10.31744/einstein_journal/2024ae1133

13.

The high biodiversity of benthic organisms in a coastal ecosystem revealed by an integrative approach
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Amaral, A. Cecília Z.

; Cunha, Beatriz P.

; Checon, Helio H.

; Godoy, Angélica S. de

; Silva, Camila F. da

; Corte, Guilherme N.

; Nogueira, João M. de M.

; Fukuda, Marcelo V.

; Steiner, Tatiana M.

; Kawauchi, Gisele Y.

; Turra, Alexander

; Denadai, Márcia R.

; Ferreira, Luciane

; Mendonça, Joel B. de

; Tavares, Marcos

; Leite, Fosca P. P.

; Costa, Mariana F. B.

; Siqueira, Silvana G. L.

; Vieira, Leandro M.

; Dias, Gustavo M.

; Teixeira, Joyce A.

; Rocha, Rosana M.

; Gusmão, Luciana C.

; Borges, Michela

; Alitto, Renata

; Machado, Fabrizio M.

; Passos, Flávio D.

; Cunha, Carlo M.

; Simone, Luiz R.L.

; Araujo, Ana Paula G.

; Carbayo, Fernando

; Bahia, Juliana

; Bulnes, Verónica N.

; Castello-Branco, Cristiana

; Hajdu, Eduardo

; Vilas-Boas, Ana Carolina

; Garraffoni, André R. S.

; Schockaert, Ernest

; Fonseca, Gustavo

; Domenico, Maikon Di

; Curini-Galletti, Marco

; Sørensen, Martin V.

; Hochberg, Rick

; Oliveira, Ana Julia F. C. de

; Zampieri, Bruna Del B.

; Chinelatto, Roberta M.

; Migotto, Alvaro E.

Biota Neotropica

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2024, Volume 24 N. 2 elocation e20231583

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Increasing habitat modification and species loss demand consistent efforts to describe and understand biodiversity patterns. The BIOTA/FAPESP Program was created in this context and it has been a successful initiative to promote studies on biodiversity and conservation in Brazil. The BIOTA/Araçá is an interdisciplinary project that provided a detailed evaluation of the biodiversity of Araçá Bay, a coastal seascape located on the North coast of the state of São Paulo, Southeast Brazil. The bay encompasses multiple habitats, such as beaches, mangroves, rocky shores, and a tidal flat, and provides important ecosystem services. Unfortunately, the bay is the subject of complex social-environmental conflicts that oppose economic, social, and environmental demands (i.e., the expansion of neighboring harbor activities vs. small-scale artisanal fisheries and protection of biodiversity). The present study presents a survey of the benthic species occurring in the different habitats of Araçá Bay, including data obtained during the BIOTA/Araçá project and previous assessments of the area. The benthic species play an important role in marine environments and studying the diversity of these organisms that live associated with the bottom is indispensable for comprehending the environment’s functioning. The macrofauna, meiofauna, and microorganisms associated with soft and hard bottom were listed, and additional information, such as the habitat and geographical distribution, were provided for each species. The checklist includes 826 species, almost 70% recorded during the BIOTA/Araçá project. The most speciose taxa were the annelids (225 spp.), mollusks (194 spp.), and crustaceans (177 spp.). Seven benthic species are endemic to Araçá Bay, 14 are considered threatened, and seven are economically exploited. Furthermore, the bay is the type locality of many taxa, and 11 new benthic species were described based on specimens sampled during the project. This project shows the importance of Araçá Bay as a unique biologically rich environment and highlights the need for conservation efforts in light of the current threats. patterns BIOTAFAPESP BIOTA FAPESP Brazil BIOTAAraçá Paulo beaches mangroves shores flat services Unfortunately socialenvironmental social economic i.e., ie i e (i.e. vs smallscale small scale biodiversity. . biodiversity) area s functioning macrofauna meiofauna listed information distribution 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. 1 threatened exploited Furthermore threats i.e. (i.e 8 7 22 (2 19 (1 17 i.e 2 (

Resumo O aumento da modificação dos habitats e da perda de espécies demanda esforços consistentes para descrever e compreender os padrões de biodiversidade. O programa BIOTA/FAPESP foi criado nesse contexto e é uma iniciativa de sucesso para promover estudos em biodiversidade e conservação no Brasil. O BIOTA/Araçá é um projeto interdisciplinar que promoveu uma avaliação detalhada da biodiversidade da Baía do Araçá, um ecossistema costeiro localizado ao Norte do estado de São Paulo, Sudeste do Brasil. A baía engloba múltiplos habitats, tais como praias, manguezais, costões rochosos, e uma planície de maré, e também fornece importantes serviços ecossistêmicos. Infelizmente, a baía está sujeita à conflitos sócio-ambientais complexos que contrastam demandas econômicas, sociais e ambientais (i.e. a expansão das atividades do porto vizinho vs. a pesca artesanal de pequena escala e a proteção da biodiversidade). O presente estudo apresenta um levantamento das espécies bentônicas que ocorrem nos diferentes habitats da Baía do Araçá, incluindo dados obtidos durante o projeto BIOTA/Araçá e de investigações realizadas anteriormente na área. As espécies bentônicas desempenham um papel importante no ambiente marinho, e estudar a diversidade desses organismos que vivem associados ao fundo é indispensável para compreender o funcionamento do meio ambiente. A macrofauna, meiofauna, e microorganismos associados aos fundos consolidado e inconsolidado foram listados, e informações adicionais foram fornecidas para cada espécie, tais como a distribuição geográfica e nos habitats. O checklist inclui 826 espécies, quase 70% registradas durante o projeto BIOTA/Araçá. Os taxa mais especiosos foram os anelídeos (225 spp.), moluscos (194 spp.), e crustáceos (177 spp.). Entre as espécies bentônicas listadas, sete são endêmicas da Baía do Araçá, 14 são consideradas ameaçadas de extinção, e sete são exploradas economicamente. A baía é a localidade tipo de vários taxa, e 11 novas espécies bentônicas foram descritas com base em espécimes amostrados durante o projeto. Este projeto mostra a importância da Baía do Araçá como um ambiente de riqueza biológica única e demonstra a necessidade de esforços para a sua conservação considerando as atuais ameaças. BIOTAFAPESP BIOTA FAPESP Brasil BIOTAAraçá Paulo praias manguezais rochosos maré ecossistêmicos Infelizmente sócioambientais sócio econômicas i.e. ie i (i.e vs . biodiversidade) área marinho macrofauna meiofauna listados espécie 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. listadas 1 extinção economicamente ameaças i.e 8 7 22 (2 19 (1 17 2 (

https://doi.org/10.1590/1676-0611-bn-2023-1583

14.

Tissue response and expression of interleukins (IL)-1ß, IL-6, IL-10 after pulp capping with bioglasses in mice IL1ß, IL1ß ILß IL 1ß, 1ß ß (IL)-1ß IL6, IL6 6, 6 IL-6 IL10 10 IL-1 IL- IL1 1
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Chaves, Hebertt Gonzaga dos Santos

; Figueiredo, Barbara

; Maia, Caroline Andrade

; Reis-Prado, Alexandre Henrique dos

; Antunes, Maísa Mota

; Mesquita, Ricardo Alves de

; Tavares, Warley Luciano Fonseca

; Menezes, Gustavo Batista

; Diniz, Ivana Márcia Alves

; Crovace, Murilo Camuri

; Avelar, Gleide Fernandes de

; Benetti, Francine

Brazilian Oral Research

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2024, Volume 38 elocation e096

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the pulp response to F18 and cobalt-doped F18 bioglass (F18Co) in comparison with calcium hydroxide (CH) after pulp capping. The maxillary first molars of 48 rats were divided into F18, F18Co, CH, and control (no intervention) groups. The pulp was exposed, the materials were placed, and the teeth were capped. After 7 and 15 days, the animals were euthanized for pulp evaluation and interleukin (IL) expression determination. Statistical analysis was carried out using the SigmaPlot® program (Systat Software Inc., for Windows, version 12.0). The data obtained in the analyses were subjected to the non-parametric Kruskal-Wallis test, followed by Dunn's test. For all tests, statistical significance was set at p < 0.05. The CH group exhibited mild to moderate inflammation, whereas the bioglass groups displayed moderate to severe inflammation, indicating a notable difference between the control and bioglass groups. At 7 days, both the CH and most of the bioglass specimens showed moderate disorganization. On day 15, CH displayed mildto-moderate disorganization, whereas F18 and F18Co exhibited significantly more moderate-to-severe disorganization. There were no significant differences in IL-6 and IL-10 expressions between groups at 7 days, but a noteworthy increase in IL-1β was observed in both CH and F18. After 15 days, there was a greater expression of IL-6 and IL-1β in the bioglass groups. No significant IL-10 expression was observed. Bioglass performed less effectively than CH when in direct contact with the pulp tissue. F F1 cobaltdoped cobalt doped FCo Co (F18Co (CH capping 4 intervention exposed placed capped 1 days IL (IL determination SigmaPlot Systat Inc Inc. Windows 12.0. 120 12.0 . 12 0 12.0) nonparametric non parametric KruskalWallis Kruskal Wallis test Dunns Dunn s tests 005 05 0.05 inflammation disorganization mildtomoderate mildto moderatetosevere IL6 6 IL- IL10 10 IL-1 IL1β ILβ 1β β tissue 12. 00 0.0 IL1 0.

https://doi.org/10.1590/1807-3107bor-2024.vol38.0096

15.

Advances and perspectives on the application of essential oils in food packaging films, coatings, and nanoencapsulated materials films coatings
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Cesca, Rafaela Silva

; Fonseca, Gustavo Graciano

; Paz, Marcelo Fossa da

; Cortez-Vega, William Renzo

Bragantia

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2024, Volume 83 elocation e20230132

Abstract: En | Text: En | PDF: En

ABSTRACT Natural additives, particularly essential oils, have gained widespread recognition for their role in enhancing the attributes of natural edible polymers. Comprising a wealth of hydrophobic and volatile compounds, essential oils exhibit notable antioxidant and antimicrobial properties owing to their rich composition of terpenes and aromatic constituents. This review underscores the multifaceted biological properties of essential oils, encompassing their incorporation into films, edible coatings, and nanoencapsulated materials. The effect of utilizing several essential oils as natural additives in combination with different raw materials and plasticizers was compared to the evaluation of their impact on the material properties of films and edible coatings, offering an in-depth analysis of the specific essential oil variants featured in the recent literature. Among the essential oils reviewed, those derived from clove, cinnamon, and oregano emerge as the predominant choices, representing some of the most promising natural additives for biodegradable packaging. Nanoencapsulation techniques have also expanded the role of essential oils in sustainable food packaging by increasing their stability. polymers compounds constituents coatings indepth depth literature reviewed clove cinnamon choices stability

https://doi.org/10.1590/1678-4499.20230132

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