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1.
Epidemic Intelligence Threat Reporting Profile in Portugal during the COVID-19: 2 Years of Decrease in Reporting on Non-COVID-19 Threats
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Peixoto, Vasco Ricoca
; Grau-Pujol, Berta
; Ourique, Matilde
; Silva, Renato Lourenço da
; Ferreira, Mariana
; Firme, Ana
; Sentís, Alexis
; Vasconcelos, Paula
.
Resumo Introdução: A epidemic intelligence (EI) assegura a deteção precoce, a avaliação e a comunicação das ameaças para a saúde pública para definir prioridades e mobilizar recursos para a investigação, vigilância, prevenção e controlo. Em Portugal, a Direção-Geral da Saúde (DGS) é responsável pela EI e publica semanalmente um relatório de ameaças para a saúde pública (RONDA) que é partilhado com a rede de autoridades de saúde, instituições e profissionais de saúde pública. As alterações nas ameaças comunicadas em relatórios periódicos de ameaças desde a COVID-19 não foram descritas anteriormente. Métodos: Comparámos as ameaças reportadas na RONDA entre 2016 a 2022 em três períodos sequenciais: antes da COVID-19 (janeiro de 2016 - março de 2020), P2 durante as restrições (abril de 2020 - fevereiro de 2022) e P3 na fase pós-aguda da COVID-19 (fevereiro de 2022 - setembro de 2022). Comparamos a frequência média mensal de ameaças não COVID-19 relatadas entre todas as ameaças relatadas nesses períodos, considerando diferentes categorias dentro do grupo de doenças, foco geográfico e fontes de informação. Resultados: As ameaças não-COVID-19 tiveram uma diminuição na frequência média mensal de reporte no Período2 (14,7 vs. 2,3 p < 0.001) em comparação com o Período1, antes da COVID-19. Houve um retorno ao padrão pré-pandêmico de notificação no Período 3 (14,67 vs. 17,63 p < 0.208) para ameaças não COVID-19 com um aumento nas doenças virais emergentes (2,20 vs. 7,62 p < 0.001). O ECDC e a OMS são as fontes de informação mais frequentes, seguidas das fontes nacionais de saúde pública. Conclusões: Durante a COVID-19, houve alterações no reporte de ameaças em Portugal. A COVID-19 possivelmente afetou a EI e os relatórios de ameaças epidémicas globais, possivelmente desviando a atenção e os recursos de outras ameaças para a pandemia. No entanto, a quantidade de ameaças que justificam o acompanhamento e a comunicação pode estar a aumentar. É necessária investigação em comunicação de ameaças detetadas no âmbito da EI a fim de assegurar que todas as ameaças relevantes são avaliadas e comunicadas de acordo com os objetivos da EI, garantindo simultaneamente o investimento em recursos e a preparação para a prevenção e resposta.
Abstract Background: Epidemic intelligence (EI) ensures early detection, assessment, and communication of public health threats. Threat reporting defines priorities and mobilize resources for surveillance, prevention, and control. In Portugal, the Directorate-General of Health (DGS) is responsible for EI and publishes a weekly public health threat report (RONDA). Changes in threats in regular threat reports since COVID-19 have not been previously described. We analysed changes in non-COVID threat reporting in the weekly threat report. Methods: Using the DGS Emergency Operations Centre’s threat reporting database, we compared threats reported in RONDAs from 2016 to 2022 in three sequential periods: P1 before COVID-19 (January 2016-March 2020), P2 during acute COVID-19 restrictions (April 2020-February 2022), and P3 in post-acute COVID-19 phase (February 2022-September 2022). We described the monthly average frequency of reports on non-COVID-19 threats in those periods considering different disease groups, geographical focus, and information sources. We estimated expected non-COVID-19 reports on threats using a forecast model fitted to the time series until March 2020 and compared observed and expected values. Results: Non-COVID-19 threats had a decrease in the monthly average frequency of reporting in period 2 (14,7 vs. 2,3 p < 0.001) compared to period 1. Using the forecast methods, there were 114 fewer non-COVID threats than the 162 expected (−70%) in period 2. In period 3, there were 105 more threats than expected (+256%). The ECDC and the WHO were the most frequent sources of information followed by national Public Health sources. Conclusions: During COVID-19, there was a decrease in reports on non-COVID threats in Portugal. COVID-19 possibly affected global EI, by shifting attention and resources from other threats to the pandemic. However, the number of threats that warrant follow-up and communication is increasing. Further research is necessary to inform the EI research and development agenda, to ensure that all relevant threats are detected, accessed, and communicated according to evolving EI objectives and priorities while resources and preparedness are guaranteed.
2.
[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio
Simões, Marcus V.
Correia, Edileide de Barros
Marcondes-Braga, Fabiana G.
Coelho-Filho, Otavio Rizzi
Mesquita, Cláudio Tinoco
Mathias-Junior, Wilson
Rochitte, Carlos Eduardo
Ramires, Felix José Alvarez
Alves, Silvia Marinho Martins
Montera, Marcelo Westerlund
Lopes, Renato Delascio
Oliveira-Junior, Mucio Tavares
Scolari, Fernando L.
Avila, Walkiria Samuel
Canesin, Manoel Fernandes
Bacal, Fernando
Bocchi, Edimar Alcides
Moura, Lídia Ana Zytynski
Saad, Eduardo Benchimol
Scanavacca, Mauricio I.
Valdigem, Bruno Pereira
Cano , Manuel Nicolas
Abizaid , Alexandre
Ribeiro, Henrique Barbosa
Lemos-Neto, Pedro Alves
Ribeiro, Gustavo Calado de Aguiar
Jatene, Fabio Biscegli
Dias, Ricardo Ribeiro
Beck-da-Silva, Luis
Rohde, Luis Eduardo P.
Bittencourt, Marcelo Imbroinise
Pereira, Alexandre
Krieger, José Eduardo
Villacorta, Humberto
Martins, Wolney de Andrade
Figueiredo-Neto, José Albuquerque de
Cardoso , Juliano Novaes
Pastore, Carlos Alberto
Jatene, Ieda Biscegli
Tanaka, Ana Cristina Sayuri
Hotta, Viviane Tiemi
Romano, Minna Moreira Dias
Albuquerque, Denilson Campos de
Mourilhe-Rocha, Ricardo
Hajjar, Ludhmila Abrahão
Brito, Fabio Sandoli de
Caramelli , Bruno
Calderaro, Daniela
Farsky, Pedro Silvio
Colafranceschi , Alexandre Siciliano
Pinto, Ibraim Masciarelli
Vieira , Marcelo Luiz Campos
Danzmann, Luiz Claudio
Barberato , Silvio Henrique
Mady, Charles
Martinelli-Filho, Martino
Torbey , Ana Flavia Malheiros
Schwartzmann, Pedro Vellosa
Macedo, Ariane Vieira Scarlatelli
Ferreira , Silvia Moreira Ayub
Schmidt, Andre
Melo , Marcelo Dantas Tavares de
Lima-Filho, Moysés Oliveira
Sposito, Andrei C.
Brito, Flavio de Souza
Biolo, Andreia
Madrini-Junior, Vagner
Rizk, Stéphanie Itala
Mesquita, Evandro Tinoco
A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE. Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).
La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).
Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.
3.
Coleoptera of Brazil: what we knew then and what we know now. Insights from the Catálogo Taxonômico da Fauna do Brasil Brazil now
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Caron, Edilson
; Monné, Marcela L.
; Ferreira, Vinicius S.
; Costa, Cleide
; Cupello, Mario
; Aloquio, Sergio
; Linzmeier, Adelita M.
; Vaz-de-Mello, Fernando Z.
; Leivas, Fernando W.T.
; Souza-Gonçalves, Igor
; Mermudes, José R.M.
; Almeida, Lúcia M.
; Moura, Luciano de A.
; Ferreira Júnior, Nelson
; Grossi, Paschoal C.
; Vanin, Sergio A.
; Ślipiński, Adam
; Anichtchenko, Alexander
; Newton, Alfred F.
; Sampaio, Aline
; Carelli, Allan
; Puker, Anderson
; Ferreira, André da S.
; Fernandes, André S.
; Roza, André S.
; Cline, Andrew
; Sampaio, Brunno H.L.
; Clarkson, Bruno
; Castro, Camila F. de
; Bicho, Carla de L.
; Benetti, César J.
; Ribeiro-Costa, Cibele S.
; Lopes-Andrade, Cristiano
; Manfio, Daiara
; Colpani, Daniara
; Basílio, Daniel S.
; Bená, Daniela de C.
; Pollock, Darren A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Chandler, Donald S.
; Nascimento, Elynton A. do
; Spiessberger, Erich L.
; Agrain, Federico A.
; Barbosa, Felipe F.
; Shockley, Floyd
; Nascimento, Francisco E. de L.
; Biffi, Gabriel
; Powell, Gareth S.
; Morse, Geoffrey E.
; Flores, Gustavo E.
; Escalona, Hermes
; Quintino, Hingrid Y.S.
; Rainho, Hugo L.
; Maddalena, Italo S.C.P.
; Hájek, Jiří
; McHugh, Joseph V.
; Botero, Juan P.
; Fuhrmann, Juares
; Churata-Salcedo, Julissa M.
; Vieira, Letícia M.
; Silveira, Luiz F.L. da
; Cruz, Luiza S. da
; Sekerka, Lukás
; Bologna, Marco A.
; Bevilaqua, Marcus V.O.
; Passos, Maria I.
; Chamorro, Maria L.
; Cherman, Mariana A.
; Bento, Matheus
; Gimmel, Matthew
; Segura, Melissa O.
; Ivie, Michael A.
; Thomas, Michael C.
; Monné, Miguel A.
; Lord, Nathan
; Hamada, Neusa
; Degallier, Nicolas
; Santos, Paula B. dos
; Duarte, Paulo R.M.
; Gnaspini, Pedro
; Bulirsch, Petr
; Regalin, Renato
; Leschen, Richard A.B.
; Constantin, Robert
; Corrêa, Rodrigo C.
; Gerstmeier, Roland
; Rosa, Simone P.
; Campos, Stéphanie V.N.
; Peck, Stewart B.
; Pacheco, Thaynara L.
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Grzymala, Traci L.
; Smith, Trevor R.
; Costa-Silva, Vinicius da
; Sandoval-Gómez, Vivian E.
; Sousa, Wesley O. de
; Tomaszewska, Wioletta
.
ABSTRACT In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, including representatives of all extant suborders and superfamilies. Our data show that the Brazilian beetle fauna is the richest on the planet, concentrating 9% of the world species diversity, with some estimates accounting to up to 15% of the global total. The most diverse family in numbers of genera is Cerambycidae (1,056 genera), while in number of species it is Chrysomelidae (6,079 species). Conotrachelus Dejean, 1835 (Curculionidae) is the most species-rich genus, with 570 species. The French entomologist Maurice Pic is the author who has contributed the most to the naming of species recorded from Brazil, with 1,794 valid names in 36 families, whereas the Brazilians Ubirajara R. Martins and Maria Helena M. Galileo are the only ones among the top-ten authors to have named species in the 21st century. Currently, approximately 144 new species of Brazilian beetles are described each year, and this average is projected to increase in the next decade to 180 species per year, or about one new Brazilian beetle every two days. 2000 ra Twentyfour Twenty four later CTFB Brasil 10 globe Costas s Brazil 35699 35 699 35,69 4958 4 958 4,95 11 country superfamilies planet 9 diversity 15 total 1,056 1056 1 056 (1,05 genera, , genera) 6,079 6079 6 079 (6,07 . species) Dejean 183 Curculionidae (Curculionidae speciesrich rich genus 57 1794 794 1,79 3 R M topten top ten st century Currently 14 year 18 days 200 3569 69 35,6 495 95 4,9 1,05 105 05 (1,0 6,07 607 07 (6,0 5 179 79 1,7 20 356 35, 49 4, 1,0 0 (1, 6,0 60 (6, 17 7 1, 2 (1 6, (6 (
4.
Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024 202 20 2
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Fernandes, Fabio
; Simões, Marcus V.
; Correia, Edileide de Barros
; Marcondes-Braga, Fabiana Goulart
; Coelho-Filho, Otavio Rizzi
; Mesquita, Cláudio Tinoco
; Mathias Junior, Wilson
; Antunes, Murillo de Oliveira
; Arteaga-Fernández, Edmundo
; Rochitte, Carlos Eduardo
; Ramires, Felix José Alvarez
; Alves, Silvia Marinho Martins
; Montera, Marcelo Westerlund
; Lopes, Renato Delascio
; Oliveira Junior, Mucio Tavares de
; Scolari, Fernando Luis
; Avila, Walkiria Samuel
; Canesin, Manoel Fernandes
; Bocchi, Edimar Alcides
; Bacal, Fernando
; Moura, Lidia Zytynski
; Saad, Eduardo Benchimol
; Scanavacca, Mauricio Ibrahim
; Valdigem, Bruno Pereira
; Cano, Manuel Nicolas
; Abizaid, Alexandre Antonio Cunha
; Ribeiro, Henrique Barbosa
; Lemos Neto, Pedro Alves
; Ribeiro, Gustavo Calado de Aguiar
; Jatene, Fabio Biscegli
; Dias, Ricardo Ribeiro
; Beck-da-Silva, Luis
; Rohde, Luis Eduardo Paim
; Bittencourt, Marcelo Imbroinise
; Pereira, Alexandre da Costa
; Krieger, José Eduardo
; Villacorta Junior, Humberto
; Martins, Wolney de Andrade
; Figueiredo Neto, José Albuquerque de
; Cardoso, Juliano Novaes
; Pastore, Carlos Alberto
; Jatene, Ieda Biscegli
; Tanaka, Ana Cristina Sayuri
; Hotta, Viviane Tiemi
; Romano, Minna Moreira Dias
; Albuquerque, Denilson Campos de
; Mourilhe-Rocha, Ricardo
; Hajjar, Ludhmila Abrahão
; Brito Junior, Fabio Sandoli de
; Caramelli, Bruno
; Calderaro, Daniela
; Farsky, Pedro Silvio
; Colafranceschi, Alexandre Siciliano
; Pinto, Ibraim Masciarelli Francisco
; Vieira, Marcelo Luiz Campos
; Danzmann, Luiz Claudio
; Barberato, Silvio Henrique
; Mady, Charles
; Martinelli Filho, Martino
; Torbey, Ana Flavia Malheiros
; Schwartzmann, Pedro Vellosa
; Macedo, Ariane Vieira Scarlatelli
; Ferreira, Silvia Moreira Ayub
; Schmidt, Andre
; Melo, Marcelo Dantas Tavares de
; Lima Filho, Moysés Oliveira
; Sposito, Andrei C.
; Brito, Flávio de Souza
; Biolo, Andreia
; Madrini Junior, Vagner
; Rizk, Stephanie Itala
; Mesquita, Evandro Tinoco
.
5.
Réquiem ao Prof. Paul McMaster Prof
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6.
Perfil e Avaliação Social de Candidatos a Transplante de Fígado: Uma Abordagem Retrospectiva Fígado
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Serrano, Luzia Cristina de Almeida
; Pereira, Vinícius Araújo
; Barbeiro, Rafael Mangas
; Duca, William José
; Silva, Rita de Cássia Martins Alves da
; Arroyo Júnior, Paulo César
; Lemes, Jemima Domingos
; Fortunato, Allana C.
; Virches, Adriano
; Miyazaki, Eliane Tiemi
; Sciarra, Adília Maria Pires
; Silva, Renato Ferreira da
.
RESUMO Introdução: A complexidade do transplante de fígado requer uma equipe altamente qualificada, no qual o assistente social desempenha papel crucial para analisar e intervir na situação social dos candidatos. Objetivos: Investigar o perfil social dos candidatos ao transplante de fígado e relacioná-lo com as intervenções e reflexões efetuadas durante a avaliação social na Unidade de Transplante de Fígado do Hospital de Base. Métodos: Com base nos registros do Serviço Social, foram analisadas as informações dos candidatos avaliados entre janeiro de 2019 e dezembro de 2020. Este estudo quantitativo-qualitativo, retrospectivo, descritivo e documental, com observação participante, foi conduzido a partir de um panorama dialético. Resultados Durante o período de coleta de dados, obteve-se174 avaliações. Perfil social: média etária de 55,8 anos, predominância masculina (N=116; 66,7%), com companheiro/a (N=129; 74,1%), residentes em municípios do estado de São Paulo (124; 71,3%), ensino fundamental incompleto (N=68, 39,1%), baixo nível de instrução (N=65; 37,4%), inatividade no mercado de trabalho (N=151; 86,8%), acessando benefício da previdência social (N=120; 69%), positiva aceitação do transplante (N=158; 90,8%), família nuclear (N=120; 69%), oferta de cuidados e aderência familiar (N= 172;98,9%), acesso parcial a medicamentos (N=122; 70,1%), facilidade de acesso ao centro transplantador (N=157; 90,2%), renda per capita familiar de 1\2 a 2 salários mínimos (N=107; 61,5%) e padrão habitacional e estado de conservação satisfatório/conservado (N=157; 90,3%). Conclusão O perfil social de maior vulnerabilidade social exigiu mais intervenções na maioria das 25 variáveis avaliadas, fornecendo elementos importantes para a identificação e atendimento das necessidades sociais de cada indivíduo. Introdução qualificada Objetivos relacionálo relacioná lo Base Métodos Social 201 2020 quantitativoqualitativo, quantitativoqualitativo quantitativo qualitativo, qualitativo quantitativo-qualitativo retrospectivo documental participante dialético dados obtevese174 obtevese obteve se174 se obteve-se17 avaliações 558 55 8 55, anos N=116 N116 N 116 (N=116 66,7%, 667 66,7% , 66 7 66,7%) companheiroa companheiro N=129 N129 129 (N=129 74,1%, 741 74,1% 74 1 74,1%) 124 (124 71,3%, 713 71,3% 71 3 71,3%) N=68, N68 68 (N=68 39,1%, 391 39,1% 39 39,1%) N=65 N65 65 (N=65 37,4%, 374 37,4% 37 4 37,4%) N=151 N151 151 (N=151 86,8%, 868 86,8% 86 86,8%) N=120 N120 120 (N=120 69%, 69 69% 69%) N=158 N158 158 (N=158 90,8%, 908 90,8% 90 90,8%) N= (N 17298,9%, 172989 172 98,9% 98 9 172;98,9%) N=122 N122 122 (N=122 70,1%, 701 70,1% 70 70,1%) N=157 N157 157 (N=157 90,2%, 902 90,2% 90,2%) 12 1\ N=107 N107 107 (N=107 61,5% 615 61 5 satisfatórioconservado satisfatório conservado 90,3%. 903 90,3% . 90,3%) avaliadas indivíduo 20 202 obtevese17 se17 obteve-se1 N=11 N11 11 (N=11 66,7 6 N=12 N12 (N=12 74,1 (12 71,3 N=68 N6 (N=6 39,1 N=6 37,4 N=15 N15 15 (N=15 86,8 90,8 17298 17298,9% 17 989 98,9 172;98,9% 70,1 90,2 N=10 N10 10 (N=10 61,5 90,3 obtevese1 se1 obteve-se N=1 N1 (N=1 66, 74, (1 71, 39, 37, 86, 90, 1729 17298,9 98, 172;98,9 70, 61, ( 17298, 172;98, 172;98 172;9 172;
ABSTRACT Introduction: The complexity of liver transplantation requires a highly qualified team, in which the social worker plays a crucial role in analyzing and intervening in the social situation of candidates. Objectives: To investigate the social profile of liver transplant candidates and relate it to the interventions and reflections made during the social assessment at the Hospital de Base Liver Transplant Unit. Methods: Based on the records of the Social Work, the information of the candidates evaluated between January 2019 and December 2020 was analyzed. This quantitative-qualitative, retrospective, descriptive and documentary study, with participant observation, was conducted from a dialectical perspective. Results: During the data collection period, 174 evaluations were obtained. Social profile: Average age 55.8 years, predominantly male (N=116; 66.7%), with a partner (N=129; 74.1%), living in municipalities in the state of São Paulo (N=124; 71.3%), incomplete primary education (N=68; 39.1%), low level of education (N=65; 37.4%), inactive in the job market (N=151; 86.8%), accessing social security benefits (N=120; 69%), positive acceptance of the transplant (N=158; 90.8%), nuclear family (N=120; 69%), offer of care and family adherence (N=172; 98.9%), partial access to medication (N=122; 70.1%), ease of access to the transplant center (N=157; 90.2%), per person family income of 1\2 to 2 minimum wages (N=107; 61.5%) and satisfactory/conserved housing standard and state of repair (N=157; 90.3%). Conclusion: The social profile of greater social vulnerability required more interventions in most of the 25 variables assessed, providing important elements for identifying and meeting the social needs of each individual. Introduction team Objectives Unit Methods Work 201 202 analyzed quantitativequalitative, quantitativequalitative quantitative qualitative, qualitative quantitative-qualitative retrospective study observation perspective Results period 17 obtained 558 55 8 55. years N=116 N116 N 116 (N=116 66.7%, 667 66.7% , 66 7 66.7%) N=129 N129 129 (N=129 74.1%, 741 74.1% 74 1 74.1%) N=124 N124 124 (N=124 71.3%, 713 71.3% 71 3 71.3%) N=68 N68 68 (N=68 39.1%, 391 39.1% 39 39.1%) N=65 N65 65 (N=65 37.4%, 374 37.4% 37 4 37.4%) N=151 N151 151 (N=151 86.8%, 868 86.8% 86 86.8%) N=120 N120 120 (N=120 69%, 69 69% 69%) N=158 N158 158 (N=158 90.8%, 908 90.8% 90 90.8%) N=172 N172 172 (N=172 98.9%, 989 98.9% 98 9 98.9%) N=122 N122 122 (N=122 70.1%, 701 70.1% 70 70.1%) N=157 N157 157 (N=157 90.2%, 902 90.2% 90.2%) 12 1\ N=107 N107 107 (N=107 61.5% 615 61 5 satisfactoryconserved satisfactory conserved 90.3%. 903 90.3% . 90.3%) Conclusion assessed individual 20 N=11 N11 11 (N=11 66.7 6 N=12 N12 (N=12 74.1 71.3 N=6 N6 (N=6 39.1 37.4 N=15 N15 15 (N=15 86.8 90.8 N=17 N17 (N=17 98.9 70.1 90.2 N=10 N10 10 (N=10 61.5 90.3 N=1 N1 (N=1 66. 74. 71. N= (N= 39. 37. 86. 90. 98. 70. 61. (N
7.
Acute effect of kinesiotherapy and neuromotor electrostimulation on thermal variation in individuals with chronic venous insufficiency
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Andrade, Danielly Lima de
; Ferreira, Ana Paula de Lima
; Brioschi, Marcos Leal
; Arruda, Rayane Laryssa da Silva
; Oliveira, Victor Franklyn de
; Melo, Renato S.
; Maia, Juliana Netto
; Andrade, Maria do Amparo
.
Resumo Introdução: A insuficiência venosa crônica (IVC) é uma alteração no sistema venoso que pode ser causada por disfunção na musculatura do tríceps sural. Objetivo: Avaliar o efeito agudo da eletroestimulação neuromuscular e da cinesioterapia sobre a flexibilidade articular do tornozelo, radiação infravermelha e força do tríceps sural de indivíduos com IVC. Métodos: Trata-se de um estudo comparativo, no qual foram avaliadas a flexibilidade do tornozelo, força de dorsiflexão e flexão plantar e variações térmicas da panturilha. Realizou-se uma sessão de eletroestimulação (corrente Aussie de 1kHz, burst = 2ms) no membro inferior direito (GE - grupo eletroestimulação) e cinesioterapia no membro inferior esquerdo (GC - grupo cinesioterapia), com alongmentos e exercícios metabólicos envolvendo o tornozelo. Resultados: Foram avaliados 19 pacientes do sexo feminino. A análise da flexibilidade do tornozelo não demonstrou alterações significantes. Na avaliação da força muscular não houve diferença intergrupos e na avaliação intragrupos apenas o GC apresentou aumento para dorsiflexão (antes do tratamento: 11,6 ± 3,5; 24h após: 13,5 ± 3,0; p = 0,02), e para flexão plantar (antes: 11,8 ± 6,3; 24h após: 14,4 ± 5,06; p = 0,04). Em relação à termografia, não houve diferença intragrupo, enquanto na avaliação intergrupo o GC apresentou aumento da temperatura imediatamente e 24h após (0,44 ± 0,68, p = 0,01 e 0,25 ± 0,83, p = 0,07, respectivamente). Quando analisada a correlação entre força de dorsiflexão e flexão plantar de ambos os membros inferiores com a amplitude do arco total do tornozelo direito e esquerdo, observou-se correlação positiva apenas entre a força de flexão plantar imediatamente após e 24h após com com amplitude de movimento e tornozelo no GC (r = 0,49, p = 0,03 e r = 0,51, p = 0,03, respectivamente). Conclusão: Não houve diferenças significantes entre a cinesioterapia e a eletroterapia quando analisada a flexibilidade e força muscular, porém a cinesioterapia foi superior no incremento de temperatura da panturrilha antes e após 24h da intervenção. Introdução IVC (IVC Objetivo Métodos Tratase Trata se comparativo panturilha Realizouse Realizou corrente 1kHz kHz 2ms ms GE cinesioterapia, , cinesioterapia) Resultados 1 feminino tratamento 116 11 6 11, 3,5 35 3 5 h 135 13 13, 3,0 30 0 0,02, 002 0,02 02 0,02) 118 8 6,3 63 144 14 4 14, 5,06 506 06 0,04. 004 0,04 . 04 0,04) termografia intragrupo 0,44 044 44 (0,4 068 68 0,68 001 01 0,0 025 25 0,2 083 83 0,83 007 07 0,07 respectivamente. respectivamente respectivamente) observouse observou 049 49 0,49 003 03 051 51 0,51 Conclusão intervenção 3, 00 6, 5,0 50 0,4 (0, 0,6 0, 2 08 0,8 05 0,5 5, (0 (
Abstract Introduction: Chronic venous insufficiency (CVI) is a change in the venous system that can be caused by dysfunction in the triceps surae muscles. Objective: To evaluate the acute effect of neuromuscular electrical stimulation and kinesio-therapy on ankle joint flexibility, infrared radiation and triceps surae strength in individuals with CVI. Methods: We conducted a comparative study, in which ankle flexibility, dorsiflexion and plantar flexion strength and thermal variations of the calf were evaluated. An electrical stimulation session (1 kHz Aussie current with burst = 2 ms) was performed on the right lower limb (EG - electrostimulation group) and kinesio-therapy on the lower limb left (KG - kinesiotherapy group), with stretching and metabolic exercises involving the ankle. Results: Nineteen female patients were evaluated. Analysis of ankle flexibility did not demonstrate significant changes. In the assessment of muscle strength, there was no difference between groups, and in the intragroup assessment, only KG showed an increase for dorsiflexion (before treatment: 11.6 ± 3.5; 24 h after: 13.5 ± 3.0; p = 0.02), and for plantar flexion (before: 11.8 ± 6.3; 24 h later: 14.4 ± 5.06; p = 0.04). Regarding thermography, there was no intragroup difference, while in the intergroup assessment, KG showed an increase in temperature immediately and 24 h later (0.44 ± 0.68, p = 0.01 and 0.25 ± 0.83, p = 0.07, respectively). When analyzing the correlation between dorsiflexion and plantar flexion strength of both lower limbs with total range of motion of the right and left ankle, a positive correlation was observed only between the plantar flexion strength immediately after and 24 h later with range of motion and ankle in KG (r = 0.49, p = 0.03 and r = 0.51, p = 0.03, respectively). Conclusion: There were no significant differences between kinesiotherapy and electrotherapy when analyzing joint flexibility and muscle strength, but kinesiotherapy was superior in increasing calf temperature before and after 24 h of intervention. Introduction CVI (CVI muscles Objective kinesio therapy Methods study evaluated 1 ( ms EG group group, , Results changes groups treatment 116 11 6 11. 3.5 35 3 5 135 13 13. 3.0 30 0 0.02, 002 0.02 02 0.02) 118 8 6.3 63 144 14 4 14. 5.06 506 06 0.04. 004 0.04 . 04 0.04) thermography 0.44 044 44 (0.4 068 68 0.68 001 01 0.0 025 25 0.2 083 83 0.83 007 07 0.07 respectively. respectively respectively) 049 49 0.49 003 03 051 51 0.51 Conclusion intervention 3. 00 6. 5.0 50 0.4 (0. 0.6 0. 08 0.8 05 0.5 5. (0
8.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
9.
Immunization in women’s lives: present and future womens women s lives
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Silva Filho, Agnaldo Lopes da
; Marinho, Ana Karolina Barreto Berselli
; Santos, André Luis Ferreira
; Maia, Angelina Farias
; Roteli-Martins, Cecilia Maria
; Fernandes, César Eduardo
; Fridman, Fabiola Zoppas
; Lajos, Giuliane Jesus
; Ballalai, Isabella
; Cunha, Juarez
; Teixeira, Julio Cesar
; Medeiros, Márcia Marly de
; Gonçalves, Manoel Afonso Guimarães
; Levi, Monica
; Neves, Nilma Antas
; Robial, Renata
; Kfouri, Renato de Ávila
; Fialho, Susana Cristina Aidé Viviani
; Magno, Valentino
.
10.
Cover crops influence the physical hydric quality of a tropical sandy soil under no-tillage cotton cropping notillage no tillage
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Silva, Pedro Luan Ferreira da
; Tormena, Cássio Antonio
; Echer, Fábio Rafael
; Cagna, Camila Pereira
; Rocha, Caroline Honorato
; Lima, Renato Paiva de
.
ABSTRACT Reduced stability and structural resilience expose sandy soils to physical degradation under intensive production systems. This study aimed to evaluate the influence of different cover crops (CC) under no-tillage system (NTS) cotton cropping, grown either individually or in combination, on the soil physical quality (SPQ) of a sandy loam Oxisol (Latossolo) in southeastern Brazil. To quantify the effects of CC on soil physical quality indicators, an experiment in randomized blocks design was implemented with the treatments: CC1: single cultivation of Ruzi grass; CC2: Intercropping of Pearl Millet + Ruzigrass; CC3: Intercropping of Pearl Millet + Velvet bean; CCMixture: Intercropping of Ruzi grass, Pearl Millet and Velvet bean; and Control: maintenance of spontaneous plants. Undisturbed samples were taken from layers 0.00-0.10, 0.10-0.20, 0.20-0.40 and 0.40-0.60 m, in which were determined the soil bulk density (Bd), total porosity (TP), available water (AW), soil penetration resistance (PR) and the least limiting water range (LLWR). According to the multivariate analyses, the CC2 treatment resulted in better SPQ compared to the other treatments. The LLWR, air-filled porosity (θAFP), and AW were responsible for differentiating the CC2 treatment compared to the other treatments evaluated. Regardless of treatments, values of Bd> 1.75 Mg m-3 result in loss of SPQ due to the significant increase in PR and decreases in AW and LLWR. In the CC3 and Control, there was a physical impediment caused by the increase in Bd in the 0.10-0.20 m layer, which could result in the confinement of cotton roots to the surface, making them more susceptible to water stress. Soil PR reached values greater than 2.5 MPa for water contents lower than the θPWP in most treatments. In treatment CC3, for water contents equivalent to the θPWP, the PR did not exceed 6 MPa, while for the other treatments, the PR reached values greater than 10 MPa. Only the PR was influenced using CC. Soil moisture is considered crucial to maintain PR below impeding values, determining the control of the physical quality of this sandy soil. systems (CC notillage no tillage NTS (NTS cropping combination (SPQ Latossolo (Latossolo Brazil indicators CC1 grass Ruzigrass bean CCMixture Control plants 0.000.10, 000010 0.00 0.10, 0 00 0.00-0.10 0.100.20, 010020 0.10 0.20, 20 0.200.40 020040 0.20 0.40 40 0.20-0.4 0.400.60 040060 0.60 60 0.40-0.6 Bd, , (Bd) TP, TP (TP) AW, (AW) (PR LLWR . (LLWR) analyses airfilled air filled θAFP, θAFP (θAFP) evaluated 175 1 75 1.7 m3 3 m- 0.100.20 0.10-0.2 layer surface stress 25 2 5 2. 000 0.000.10 00001 0.0 010 0.00-0.1 100 01002 0.1 020 200 0.200.4 02004 0.2 040 0.4 4 0.20-0. 400 0.400.6 04006 060 0.6 0.40-0. (Bd (TP (AW (LLWR (θAFP 17 7 1. 0.100.2 0.10-0. 0.000.1 0000 0. 01 0.00-0. 0100 02 0.200. 0200 04 0.20-0 0.400. 0400 06 0.40-0 0.100. 0.10-0 0.000. 0.00-0 0.200 0.20- 0.400 0.40- 0.100 0.10- 0.000 0.00-
11.
Correlation between body mass index and joint pain intensity with gait performance in individuals with osteoarthritis
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Nascimento, Sthefany Ellen de Araújo
; Matias, Nyvea Maria de Souza
; Ferreira, Ana Isabel da Silva
; Lorêdo, Menberson Santana Souza
; Raposo, Maria Cristina Falcão
; Melo, Renato de Souza
.
resumo JUSTIFICATIVA E OBJETIVOS: Indivíduos com osteoartrite (OA) frequentemente apresentam dor articular e sobrepeso ou obesidade. Assim, o objetivo deste estudo foi observar se existe correlação entre o índice de massa corporal e a intensidade da dor articular com o desempenho da marcha em indivíduos com OA. MÉTODOS: Estudo de corte transversal, que avaliou 60 indivíduos, sendo 30 com diagnóstico clínico de osteoartrite de joelho e 30 sem a doença, de ambos os sexos e com faixa etária entre 50 e 82 anos. A intensidade da dor articular foi avaliada pela Escala Analógica Visual, as tarefas funcionais relacionadas à marcha pelo Dynamic Gait Index e a mobilidade funcional pelo teste Timed Up and Go. RESULTADOS: Houve correlação entre o sobrepeso/obesidade e níveis elevados de intensidade da dor articular (p=0,018), com um pior desempenho nas tarefas funcionais relacionadas à marcha (p=0,000) e com menor mobilidade funcional (p=0,034) apenas para os indivíduos com OA. Os níveis elevados de intensidade de dor articular também mostraram correlação com um pior desempenho nas tarefas funcionais relacionadas à marcha (p=0,000) no grupo com OA, e ainda, com uma menor mobilidade funcional no grupo com OA (p=0,001) e também no grupo de indivíduos sem a doença (p=0,032). CONCLUSÃO: Este estudo identificou correlação entre o sobrepeso/obesidade com níveis elevados de intensidade da dor articular e com um pior desempenho na marcha nos indivíduos com OA. Os elevados níveis de intensidade da dor também mostraram correlação com pior desempenho na marcha nos indivíduos com OA. OBJETIVOS (OA obesidade Assim MÉTODOS transversal 6 3 5 8 anos Visual Go RESULTADOS sobrepesoobesidade p=0,018, p0018 p p=0,018 , 0 018 (p=0,018) p=0,000 p0000 000 (p=0,000 p=0,034 p0034 034 (p=0,034 ainda p=0,001 p0001 001 (p=0,001 p=0,032. p0032 p=0,032 . 032 (p=0,032) CONCLUSÃO p001 p=0,01 01 (p=0,018 p=0,00 p000 00 (p=0,00 p=0,03 p003 03 (p=0,03 (p=0,032 p00 p=0,0 (p=0,01 (p=0,0 p0 p=0, (p=0, p=0 (p=0 p= (p= (p
ABSTRACT BACKGROUND AND OBJECTIVES: Individuals with osteoarthritis (OA) often have joint pain and are overweight or obese. Thus, the objective of this study was to observe whether there is correlation between body mass index and joint pain intensity with gait performance in individuals with OA. METHODS: Cross-sectional study, which evaluated 60 volunteers, being 30 with clinical diagnosis of knee osteoarthritis and 30 without the disease, of both sexes and aged between 50-82 years. Joint pain intensity was assessed using the Visual Analog Scale, gait-related functional tasks using the Dynamic Gait Index, and the functional mobility using the Timed Up and Go test. RESULTS: There was a correlation between overweight/obesity and high levels of joint pain intensity (p=0.018), with worse performance in gait-related functional tasks (p=0.000) and with worse functional mobility (p=0.034) only for the individuals with OA. High levels of joint pain intensity also correlated with worse performance in the gait-related functional tasks (p=0.000) in the OA group, and also with worse functional mobility in the OA group (p=0.001) and also in the group of individuals without the disease (p=0.032). CONCLUSION: This study identified a correlation between overweight/obesity and high levels of joint pain intensity and worse gait performance in individuals with osteoarthritis. High levels of pain intensity also correlated with worse gait performance in individuals with OA. OBJECTIVES (OA obese Thus METHODS Crosssectional Cross sectional 6 volunteers 3 5082 50 82 50-8 years Scale gaitrelated related Index test RESULTS overweightobesity obesity p=0.018, p0018 p p=0.018 , 0 018 (p=0.018) p=0.000 p0000 000 (p=0.000 p=0.034 p0034 034 (p=0.034 p=0.001 p0001 001 (p=0.001 p=0.032. p0032 p=0.032 . 032 (p=0.032) CONCLUSION 508 5 8 50- p001 p=0.01 01 (p=0.018 p=0.00 p000 00 (p=0.00 p=0.03 p003 03 (p=0.03 (p=0.032 p00 p=0.0 (p=0.01 (p=0.0 p0 p=0. (p=0. p=0 (p=0 p= (p= (p
12.
Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens disorders NS
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França, Laise Carolina
; Fontes-Dantas, Fabrícia Lima
; Garcia, Diogo Gomes
; Araújo, Amanda Dutra de
; Gonçalves, João Paulo da Costa
; Rêgo, Cláudia Cecília da Silva
; Silva, Elielson Veloso da
; Nascimento, Osvaldo José Moreira do
; Lopes, Fernanda Cristina Rueda
; Herlinger, Alice Laschuk
; Aguiar, Renato Santana de
; Ferreira Junior, Orlando da Costa
; Figueira, Fernando Faria Andrade
; Souza, Jorge Paes Barreto Marcondes de
; Mesquita, Joelma Freire De
; Alves-Leon, Soniza Vieira
.
Resumo Antecedentes Evidências indicam uma forte ligação entre o vírus Zika (ZikV) e complicações neurológicas. Mielite aguda, neurite óptica, polineuropatia e encefalomielite que mimetizam distúrbios inflamatórios de desmielinização idiopáticos (DDII) após infecção por ZikV têm sido relatadas no Brasil. Obejtivo O presente estudo tem como objetivo investigar a possível ocorrência de mimetismo molecular entre antígenos do ZikV e autoantígenos da Esclerose Múltipla (EM), a DDII mais frequente do sistema nervoso central (SNC). Métodos Foi realizado um estudo de coorte retrospectivo com 305 pacientes internados por suspeita de infecção por arbovirus no Rio de Janeiro, todos os indivíduos foram submetidos a exame neurológico e coleta de amostra biológica para diagnóstico sorológico e molecular. Ferramentas de bioinformática foram usadas para analisar os peptídeos compartilhados entre antígenos do ZikV e autoantígenos da EM. Resultados Dos 305 pacientes, vinte e seis foram positivos para ZikV e 4 apresentaram padrão IDD encontrado em casos de EM. As comparações de homologia de sequência por abordagem de bioinformática entre a proteína NS5 ZikV e PLP EM revelaram uma homologia de 5/6 aminoácidos consecutivos (CSSVPV/CSAVPV) com 83% de identidade, deduzindo um mimetismo molecular. A análise das estruturas 3D revelou uma conformação semelhante com apresentação em alfa-hélice. Conclusões O mimetismo molecular entre o antígeno NS5 do vírus Zika e o autoantígeno PLP da EM surge como um possível mecanismo para o espectro IDD em indivíduos geneticamente suscetíveis. (ZikV neurológicas aguda óptica (DDII Brasil EM, , (EM) SNC. SNC . (SNC) 30 Janeiro NS 56 5 6 5/ CSSVPV/CSAVPV CSSVPVCSAVPV CSSVPV CSAVPV (CSSVPV/CSAVPV 83 identidade D alfahélice. alfahélice alfa hélice. hélice alfa-hélice suscetíveis (EM (SNC 3 8
Abstract Background Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (HDD) after ZikV infection have been reported in Brazil. Objective The present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent HDD of the central nervous system (CNS). Methods A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination, and a biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens. Results Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD patterns found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV and PLP MS protein revealed a homology of 5/6 consecutive amino acids (CSSVPV/CSAVPV) with 83% identity, deducing a molecular mimicry. Analysis of the 3D structures revealed a similar conformation with alpha helix presentation. Conclusions Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals. (ZikV complications myelitis neuritis polyneuropathy (HDD Brazil (MS CNS. CNS . (CNS) 30 performed examination diagnostic twentysix twenty six cases NS 56 5 6 5/ CSSVPV/CSAVPV CSSVPVCSAVPV CSSVPV CSAVPV (CSSVPV/CSAVPV 83 identity D presentation individuals (CNS 3 8
13.
The adoption of technological tools in continuous audit projects
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Andrade, Augusto Cezar Romeiro de
; Penha, Renato
; Silva, Luciano Ferreira da
; Bizarrias, Flavio Santino
; Kniess, Claudia Terezinha
.
RESUMO Objetivo: Apresentar um modelo conceitual para adoção de ferramentas tecnológicas em projetos de auditoria contínua. Metodologia: Esta pesquisa está constituída em uma perspectiva de abordagem qualitativa com natureza descritiva, dividida em duas fases. Na primeira fase foi realizada uma Revisão Sistemática de Literatura com foco nas ferramentas tecnológicas e Projetos de Auditoria Contínua e, na segunda fase, foi realizada uma pesquisa de campo por meio da realização de entrevistas de profundidade com profissionais relacionados ao tema. Limitações/implicações da pesquisa: O estudo limita-se a identificar as ferramentas tecnológicas em Projetos de Auditoria Contínua. Resultados: Os resultados apontaram os principais benefícios e desafios encontrados na adoção de ferramentas tecnológicas em Projetos de Auditoria Contínua. Os resultados apontaram os nove fatores principais, dentre eles, os elementos habilitadores para a adoção de ferramentas tecnológicas em Projetos de Auditoria Contínua. Originalidade: Apesar das ferramentas tecnológicas existentes, ainda é incipiente na literatura pesquisada identificar os desafios e as barreiras enfrentados pelas organizações para apoio nos projetos de Projetos de Auditoria Contínua. Implicações práticas: Esta pesquisa oferece um modelo conceitual como instrumento norteador para a adoção de ferramentas tecnológicas em Projetos de Auditoria Contínua para as organizações inseridas em um contexto de Auditoria Interna. O modelo apresenta os principais elementos habilitadores que garantem o ambiente necessário para o desenvolvimento do projeto aos envolvidos em Projetos de Auditoria Contínua. Objetivo contínua Metodologia descritiva fases tema Limitaçõesimplicações Limitações implicações limitase limita se Resultados eles Originalidade existentes práticas Interna
ABSTRACT Purpose: Present a conceptual model for the adoption of technological tools in continuous audit projects. Design/methodology/approach: This research is constituted from the perspective of a qualitative approach with a descriptive nature, divided into two phases. In the first phase, a Systematic Literature Review was conducted focusing on technological tools and Continuous Audit Projects, in the second phase, field research was conducted through in-depth interviews with professionals related to the theme. Findings: The results indicated the main benefits and challenges encountered in the adoption of technological tools in Continuous Audit Projects. The results pointed out the nine main factors, among them, the enabling elements for the adoption of technological tools in Continuous Audit Projects. Research limitations/implications: The study is limited to identifying the technological tools in Continuous Audit Projects. Originality/Value: Despite the existing technological tools, it is still incipient in the literature researched to identify the challenges and barriers faced by organizations to support the projects of Continuous Audit Projects. Practical implications: This research offers a conceptual model as a guiding instrument for the adoption of technological tools in Continuous Audit Projects for organizations inserted in an Internal Audit context. The model presents the main enabling elements that ensure the environment necessary for the development of the project to those involved in Continuous Audit Projects. Purpose Design/methodology/approach Designmethodologyapproach Design methodology nature phases phase indepth depth theme Findings factors them limitations/implications limitationsimplications limitations implications Originality/Value OriginalityValue Originality Value context
14.
High prevalence of hepatitis B virus and low vaccine response in children and adolescents in Northeastern Brazil
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Castro, Rogério Soares
; Cordeiro, Bárbara Silva
; Rolim, Marco Aurélio Ferreira
; Costa, Alessandra Porto de Macedo
; Santos, Max Diego Cruz
; Silva, Marcos Antonio Custódio Neto da
; Albuquerque, Ingrid de Campos
; Fonseca, Lena Maria Barros
; Pinho, João Renato Rebello
; Gouvêa, Michelle Soares Gomes
; Silva, Antônio Augusto Moura da
; Ferreira, Adalgisa de Souza Paiva
.
Revista do Instituto de Medicina Tropical de São Paulo
- Journal Metrics
ABSTRACT Children have an increased likelihood of becoming carriers of the chronic hepatitis B virus. A total of 1,381 children and adolescents were assessed in five municipalities of Maranhao State, Brazil, for detection of anti-HBc, HBsAg and anti-HBs serologic markers and sociodemographic and behavioral features. Among those who were HBsAg negative and anti-HBc negative, the proportion of anti-HBs positives was calculated after the individuals had completed the vaccination schedule. The robust variance of the Poisson’s regression model was used in order to have adjusted tables and calculate the prevalence ratio. Multivariate analysis was performed to identify the factors associated with the prevalence of anti-HBc with or without HBsAg and the vaccine response. It was observed that 163 children were anti-HBc positive and nine individuals were HBsAg positive. The factors associated with the infection were: municipality of residence (residing in Morros municipality or Humberto de Campos municipality), residence in a rural area, aged between 13 and 15 years old, and illicit drug use. The percentage of individuals who were anti-HBc negative and received all three doses of the vaccine was 48.5%. Among these, only 276 (38.9%) had antibodies at protective concentrations. In an adjusted analysis, Morros municipality presented an increased positivity of vaccine response (p < 0.001), and the age ranging between 6 and 10 years old presented a reduced frequency of response. This study reveals a high prevalence of current and past HBV infection within the targeted age group which, in addition to the low vaccination coverage and serological responses, raises concerns about the management of prevention measures, especially the quality of vaccination in these locations. virus 1381 1 381 1,38 State Brazil antiHBc, antiHBc anti HBc, HBc antiHBs HBs features schedule Poissons Poisson s ratio 16 residing municipality, , municipality) area use 485 48 5 48.5% 27 38.9% 389 38 9 (38.9% concentrations p 0.001, 0001 0.001 0 001 0.001) which responses measures locations 138 1,3 4 48.5 2 38.9 3 (38.9 000 0.00 00 1, 48. 38. (38. 0.0 (38 0. (3 (
15.
Selective photodynamic effects on cervical adenocarcinoma cells provided by F127 Pluronic®-based micelles modulating hypericin delivery F F12 Pluronic®based Pluronicbased Pluronic® based Pluronic F1
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Mashiba, Kayane Harumi
; Carobeli, Lucimara Rofrigues
; Souza, Maria Vítoria Felipe de
; Meirelles, Lyvia Eloiza de Freitas
; Mari, Natália Lourenço
; César, Gabriel Batista
; Gonçalves, Renato Sonchini
; Caetano, Wilker
; Damke, Edilson
; Silva, Vânia Ramos Sela da
; Damke, Gabrielle Marconi Zago Ferreira
; Consolaro, Marcia Edilaine Lopes
.
Abstract Cervical cancer is a leading cause of death among women. The endocervical adenocarcinoma (ECA) represents an aggressive and metastatic type of cancer with no effective treatment options currently available. We evaluated the antitumoral and anti-migratory effects of hypericin (HYP) encapsulated on Pluronic F127 (F127/HYP) photodynamic therapy (PDT) against a human cell line derived from invasive cervical adenocarcinoma (HeLa) compared to a human epithelial cell line (HaCaT). The phototoxicity and cytotoxicity of F127/HYP were evaluated by the following assays: colorimetric assay, MTT, cellular morphological changes by microscopy and long-term cytotoxicity by clonogenic assay. In addition, we performed fluorescence microscopy to analyze cell uptake and subcellular distribution of F127/HYP, cell death pathway and reactive oxygen species (ROS) production. The PDT mechanism was determined with sodium azide and D-mannitol and cell migration by wound-healing assay. The treatment with F127/HYP promoted a phototoxic result in the HeLa cells in a dose-dependent and selective form. Internalization of F127/HYP was observed mainly in the mitochondria, causing cell death by necrosis and ROS production especially by the type II PDT mechanism. Furthermore, F127/HYP reduced the long-term proliferation and migration capacity of HeLa cells. Overall, our results indicate a potentially application of F127/HYP micelles as a novel approach for PDT with HYP delivery to more specifically treat ECA. women ECA (ECA available antimigratory anti migratory (HYP F F12 F127HYP FHYP (F127/HYP (PDT (HeLa HaCaT. HaCaT . (HaCaT) assays assay MTT longterm long term addition (ROS Dmannitol D mannitol woundhealing wound healing dosedependent dose dependent form mitochondria Furthermore Overall F1 (HaCaT
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