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au:Ferreira, Juliana Mota

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Technological Prospection and Scientific Innovation of Ilex paraguariensis Saint-Hilaire in the Wound Healing Process SaintHilaire Saint Hilaire
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Clemente, Pedro Augusto

; Mendonça, Kelby Cavalheiro

; Andrade, Giovana Frazon de

; Goncalves, Larisse Medeiros

; Godoy, Cristiane Maria Tonetto

; Rocha, Jhonatan Matheus Piaceski

; Silva, Weber Claudio Francisco Nunes da

; Reolon, Jéssica Brandão

; Ferreira, Daiane Finger

; Vieira, Maria Cristina Umpierrez

; Silva, Juliana Maria

; Ferreira, Luana Mota

; Bonini, Juliana Sartori

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230086

Abstract: En | Text: En | PDF: En

Abstract Natural compounds are possible alternatives for wound treatment, including Ilex paraguariensis, a plant with several pharmacological actions already reported, including anti-inflammatory, antibacterial, antioxidant, and healing activities. Therefore, this study aimed to perform a technological and scientific mapping of Ilex paraguariensis used for healing and/or analgesic purposes. Technological prospection was carried out in the Questel-Orbit system, while the scientific research was carried out in PubMed, Web of Science, and SCOPUS databases. The terms “Ilex paraguariensis”, “Yerba-mate”, “Painkiller”, “Analgesic”, “Wound”, “Healing”, and “Scar” were combined using Boolean operators “OR” and “AND”. The technological prospection resulted in 164 patents found initially. After sorting the abstracts, five patents were read entirely, of which three were selected. Such selected patents report using Ilex paraguariensis for analgesics, wound healing, personal care, and pharmaceutical applications. In addition, the scientific research showed a small number of studies aimed at using Ilex paraguariensis for healing and/or analgesic purposes. Among the 26 articles initially found, only 5 met the inclusion requirements. Scientific studies demonstrate that Ilex paraguariensis is used as an extract or drink, presenting promising results regarding analgesia, inflammation, and wound healing, using in vitro or in vivo models. Despite the potential of Ilex paraguariensis in skin wound therapy, our study demonstrates that few patents and scientific studies explore Ilex paraguariensis for this purpose. This fact may be an incentive for the development of further studies employing Ilex paraguariensis in cutaneous wound management and the pain associated with them. treatment reported antiinflammatory, antiinflammatory anti inflammatory, inflammatory anti-inflammatory antibacterial antioxidant activities Therefore andor purposes QuestelOrbit Questel Orbit system PubMed Science databases , paraguariensis” Yerbamate, Yerbamate Yerba mate “Yerba-mate” Painkiller, Painkiller “Painkiller” Analgesic, Analgesic “Analgesic” Wound, Wound “Wound” Healing, Healing “Healing” Scar “Scar OR “OR AND. AND . “AND” 16 abstracts entirely analgesics care applications addition 2 requirements drink analgesia inflammation models therapy purpose them “Yerba-mate “Painkiller “Analgesic “Wound “Healing “AND 1

https://doi.org/10.1590/1678-4324-2024230086

Food Introduction and Its Implications on the Development of Celiac Disease in Childhood
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Oliveira, Giovanna Tardem

; Rocha Junior, Odonis

; Ferreira, Luana Mota

; Reolon, Jéssica Brandão

; Bonini, Juliana Sartori

; Sari, Marcel Henrique Marcondes

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24230928

Abstract: En | Text: En | PDF: En

Abstract This study investigated the relationship between food introduction and celiac disease development. This bibliographic review was conducted from May to June 2023 and covered publications from 2013 to 2023. The Virtual Health Library (VHL) and PubMed databases were used, with the following search terms: “Celiac Disease,” “Gluten enteropathy” (with the Boolean operator “OR”), “Infant,” “Preschooler” (also using the Boolean operator “OR”) and “Food Introduction.” A total of 28 articles were found and, after careful analysis, only 6 met the inclusion and exclusion criteria. These articles addressed topics such as the relationship between dietary patterns and the risk of celiac disease, the prevalence of the disease in children born before and after the epidemic in Sweden, the feasibility of introducing allergens and their relationship with breastfeeding, and the implications of introducing gluten into the diet and early weaning in celiac disease. The results of the study highlight the importance of further research into this topic to develop possible methods of prevention and intervention in the manifestation process of celiac disease. From the bibliographic review, it was possible to identify the variables that imply the development of celiac disease and refute the hypotheses of the direct influence of the early introduction of gluten in the diet on the manifestation of the disease. 202 201 VHL (VHL used terms Celiac Disease, Disease Gluten enteropathy OR, OR , Infant, Infant “Infant, Preschooler “Preschooler also “OR” Food Introduction. Introduction 2 analysis criteria Sweden breastfeeding 20 “Infant “OR

https://doi.org/10.1590/1678-4324-2024230928

Predictive Modeling of Rheological Behavior in Semisolid Pharmaceutical Formulations Using Computational Tools. Tools
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Reolon, Jéssica Brandão

; Hammerschmitt, Bruno Knevitz

; Sari, Marcel Henrique Marcondes

; Lazo, Raul Edison Luna

; Cobre, Alexandre de Fátima

; Capeletti, Marcelo Bruno

; Rigo, Maurício

; Bonini, Juliana Sartori

; Abaide, Alzenira da Rosa

; Pontarolo, Roberto

; Ferreira, Luana Mota

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24240050

Abstract: En | Text: En | PDF: En

Abstract Topical treatments for skin conditions offer significant benefits, yet understanding the rheological characteristics of semi-solid formulations is crucial, as they directly influence treatment adherence through their applicability. Ideally, these formulations should maintain their placement at the application site and facilitate easy spreading without requiring excessive force, particularly on painful lesions. In this study, a Python-based tool was developed to assess the rheological behavior of formulations, with a gel-cream serving as a model to demonstrate its applicability. The model formulation was created by emulsifying an oily phase, including blackcurrant oil, with an aqueous phase containing xanthan gum as a gelling agent. Rheological parameters were determined using a rotational viscometer. The prepared gel-cream exhibited pseudoplastic behavior, with viscosity decreasing as rotation speed increased. The Python tool was utilized to extract information about the rheological properties of the samples. Upon applying the data to various mathematical models, it was confirmed that the formulations displayed pseudoplasticity, with the Ostwald-de-Waele model demonstrating the best fit for all evaluated formulations. This pseudoplastic behavior was further confirmed by calculating the flow index (ɳ), which was found to be lower than 1. Open-source tools are gaining popularity across various industries due to their transparency, collaborative nature, and cost-effectiveness. They enable users to enhance product properties, explore therapeutic targets, facilitate efficient collaboration, develop customized software, create predictive models, and ensure regulatory compliance. Our study offers a precise solution for determining the rheological behavior of semi-solid formulations while mitigating human estimation errors. However, it's important to note that proficiency in programming is required to utilize this tool effectively. benefits semisolid semi solid crucial applicability Ideally force lesions Pythonbased based gelcream gel cream oil agent viscometer increased samples models pseudoplasticity OstwalddeWaele Ostwald de Waele ɳ, ɳ , (ɳ) 1 Opensource Open source transparency nature costeffectiveness. costeffectiveness cost effectiveness. effectiveness cost-effectiveness targets collaboration software compliance errors However s effectively (ɳ

https://doi.org/10.1590/1678-4324-2024240050

Vulnerabilidade clínico funcional masculina entre idosos institucionalizados
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Araújo, Jeferson Santos

; Chaves, Elaine Ferreira

; Salgado, Juliana Mota

; Quemel, Glenda Keyla China

; Silva, Silvio Eder Dias da

; Sousa, Fabianne de Jesus Dias de

Enfermería Actual de Costa Rica

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dec 2021, N. 41 elocation 47012

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

Resumen Objetivo: Analizar la vulnerabilidad clínica funcional masculina entre adultos mayores institucionalizados en dos unidades de cuidados de largo plazo utilizando el Índice de Vulnerabilidad Clínica Funcional (IVCF-20). Método: Se trata de un estudio transversal y comparativo, se utilizó una muestra de conveniencia, participaron 31 adultos mayores institucionalizados en dos Instituciones de Larga Duración ubicadas en el municipio de Marabá-PA, de enero a mayo de 2019. Para la vulnerabilidad se utilizó el instrumento IVCF-20 y se aplicó la prueba G para el análisis estadístico, considerando el nivel de significancia de p≤0.05. Todos los preceptos éticos en la investigación estaban garantizados. Resultados: Predominó el grupo de edad entre 60-74 años, solteros, jubilados y con bajo nivel educativo. Los adultos mayores institucionalizados tenían algunas enfermedades previas, como la hipertensión arterial sistémica (50 %), seguida de la hiperplasia prostática (36,8%). En cuanto a la vulnerabilidad, los grupos mostraron deterioro en las actividades básicas e instrumentales de la vida diaria, en cognición, de humor, movilidad en términos de alcanzar o agarrar objetos, capacidad aeróbica y muscular durante la marcha y pérdida urinaria y fecal. Los adultos mayores pertenecientes a la institución A tenían una vulnerabilidad clínica funcional más comprometida que los pertenecientes a la institución B. Conclusión: Los resultados muestran un alto grado de vulnerabilidad de los adultos mayores institucionalizados, ampliando las discusiones sobre políticas públicas dirigidas a la población masculina adulta mayor.

Resumo Objetivo: Analisar a vulnerabilidade clínico funcional masculina entre idosos institucionalizados em duas unidades de longa permanência por meio do instrumento Índice de Vulnerabilidade Clínico Funcional (IVCF-20). Metodologia: Trata-se de um estudo transversal e comparativo, no qual se utilizou uma amostra por conveniência em que participaram 31 homens idosos institucionalizados em duas Instituições de Longa Permanência localizadas no município de Marabá-PA, no período de janeiro a maio de 2019. Para a vulnerabilidade, utilizou-se o instrumento IVCF-20 e para a análise estatística foi aplicado o Teste G considerando o nível de significância de p≤0,05. Todos os preceitos éticos em pesquisa foram assegurados. Resultados: Nos grupos predominaram a faixa etária entre 60-74 anos, solteiros, aposentados e com grau de escolaridade baixo. Os idosos institucionalizados apresentavam algumas doenças prévias como Hipertensão Arterial Sistêmica (50%) seguido de Hiperplasia da Próstata (36,8%). Quanto a vulnerabilidade, os grupos apresentaram comprometimento nas atividades de vida diária básicas e instrumentais; na cognição; no humor; na mobilidade no que tange ao alcance e/ou preensão de objetos, na capacidade aeróbica e muscular, durante a marcha e na perda urinária e fecal. Os idosos pertencentes a instituição A apresentaram vulnerabilidade clínica funcional mais comprometida do que idosos pertencentes a instituição B. Conclusão: Os resultados evidenciam alto grau de vulnerabilidade dos idosos institucionalizados ampliando discussões sobre as políticas públicas direcionadas à população idosa masculina.

Abstract Aim: To analyze functional clinical vulnerability in institutionalized elderly males in two long-term care units using the Functional Clinical Vulnerability Index (IVCF-20). Method: This is a cross-sectional and comparative study. A convenience sample was used, and as a result, 31 senior males in two institutionalized long-term institutions located in the municipality of Marabá-PA from January to May 2019 participated in the study. The IVCF-20 instrument was used to evaluate the vulnerability; a G test was applied for the statistical analysis considering a significance level of p≤0.05. All ethical requirements for research were guaranteed. Results: Among all groups, the age group between 60-74 years old, single, retired, and with a low level of education predominated. Institutionalized older people had some previous diseases such as Systemic Arterial Hypertension (50%) followed by Prostate Hyperplasia (36,8%). As for vulnerability, the groups showed an impairment in basic and instrumental activities of daily living, in cognition, in mood, mobility about reaching and / or grasping objects, aerobic and muscular capacity, gait, and urinary and fecal loss. The elderly belonging to institution A had more compromised functional clinical vulnerability than the elderly belonging to institution B. Conclusion: The results show a high degree vulnerability in institutionalized elderly citizens; discussions about public policies aimed at the elderly male population should expand.

https://doi.org/10.15517/revenf.v0i41.44483

Differences in children and adolescents with SARS-CoV-2 infection: a cohort study in a Brazilian tertiary referral hospital
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Marques, Heloisa Helena de Sousa

; Pereira, Maria Fernanda Badue

; Santos, Angélica Carreira dos

; Fink, Thais Toledo

; Paula, Camila Sanson Yoshino de

; Litvinov, Nadia

; Schvartsman, Claudio

; Delgado, Artur Figueiredo

; Gibelli, Maria Augusta Bento Cicaroni

; Carvalho, Werther Brunow de

; Odone Filho, Vicente

; Tannuri, Uenis

; Carneiro-Sampaio, Magda

; Grisi, Sandra

; Duarte, Alberto José da Silva

; Antonangelo, Leila

; Francisco, Rossana Pucineli Vieira

; Okay, Thelma Suely

; Batisttella, Linamara Rizzo

; Carvalho, Carlos Roberto Ribeiro de

; Brentani, Alexandra Valéria Maria

; Silva, Clovis Artur

; Eisencraft, Adriana Pasmanik

; Rossi Junior, Alfio

; Fante, Alice Lima

; Cora, Aline Pivetta

; Reis, Amelia Gorete A. de Costa

; Ferrer, Ana Paula Scoleze

; Andrade, Anarella Penha Meirelles de

; Watanabe, Andreia

; Gonçalves, Angelina Maria Freire

; Waetge, Aurora Rosaria Pagliara

; Silva, Camila Altenfelder

; Ceneviva, Carina

; Lazari, Carolina dos Santos

; Abellan, Deipara Monteiro

; Santos, Emilly Henrique dos

; Sabino, Ester Cerdeira

; Bianchini, Fabíola Roberta Marim

; Alcantara, Flávio Ferraz de Paes

; Ramos, Gabriel Frizzo

; Leal, Gabriela Nunes

; Rodriguez, Isadora Souza

; Pinho, João Renato Rebello

; Carneiro, Jorge David Avaizoglou

; Paz, Jose Albino

; Ferreira, Juliana Carvalho

; Ferranti, Juliana Ferreira

; Ferreira, Juliana de Oliveira Achili

; Framil, Juliana Valéria de Souza

; Silva, Katia Regina da

; Kanunfre, Kelly Aparecida

; Bastos, Karina Lucio de Medeiros

; Galleti, Karine Vusberg

; Cristofani, Lilian Maria

; Suzuki, Lisa

; Campos, Lucia Maria Arruda

; Perondi, Maria Beatriz de Moliterno

; Diniz, Maria de Fatima Rodrigues

; Fonseca, Maria Fernanda Mota

; Cordon, Mariana Nutti de Almeida

; Pissolato, Mariana

; Peres, Marina Silva

; Garanito, Marlene Pereira

; Imamura, Marta

; Dorna, Mayra de Barros

; Luglio, Michele

; Rocha, Mussya Cisotto

; Aikawa, Nadia Emi

; Degaspare, Natalia Viu

; Sakita, Neusa Keico

; Udsen, Nicole Lee

; Scudeller, Paula Gobi

; Gaiolla, Paula Vieira de Vincenzi

; Severini, Rafael da Silva Giannasi

; Rodrigues, Regina Maria

; Toma, Ricardo Katsuya

; Paula, Ricardo Iunis Citrangulo de

; Palmeira, Patricia

; Forsait, Silvana

; Farhat, Sylvia Costa Lima

; Sakano, Tânia Miyuki Shimoda

; Koch, Vera Hermina Kalika

; Cobello Junior, Vilson

Clinics

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2021, Volume 76 elocation e3488

Abstract: En | Text: En | PDF: En

OBJECTIVES: To compare demographic/clinical/laboratory/treatments and outcomes among children and adolescents with laboratory-confirmed coronavirus disease 2019 (COVID-19). METHODS: This was a cross-sectional study that included patients diagnosed with pediatric COVID-19 (aged <18 years) between April 11, 2020 and April 22, 2021. During this period, 102/5,951 (1.7%) of all admissions occurred in neonates, children, and adolescents. Furthermore, 3,962 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection samples were processed in patients aged <18 years, and laboratory-confirmed COVID-19 occurred in 155 (4%) inpatients and outpatients. Six/155 pediatric patients were excluded from the study. Therefore, the final group included 149 children and adolescents (n=97 inpatients and 52 outpatients) with positive SARS-CoV-2 results. RESULTS: The frequencies of sore throat, anosmia, dysgeusia, headache, myalgia, nausea, lymphopenia, pre-existing chronic conditions, immunosuppressive conditions, and autoimmune diseases were significantly reduced in children and adolescents (p<0.05). Likewise, the frequencies of enoxaparin use (p=0.037), current immunosuppressant use (p=0.008), vasoactive agents (p=0.045), arterial hypotension (p<0.001), and shock (p=0.024) were significantly lower in children than in adolescents. Logistic regression analysis showed that adolescents with laboratory-confirmed COVID-19 had increased odds ratios (ORs) for sore throat (OR 13.054; 95% confidence interval [CI] 2.750-61.977; p=0.001), nausea (OR 8.875; 95% CI 1.660-47.446; p=0.011), and lymphopenia (OR 3.575; 95% CI 1.355-9.430; p=0.010), but also had less hospitalizations (OR 0.355; 95% CI 0.138-0.916; p=0.032). The additional logistic regression analysis on patients with preexisting chronic conditions (n=108) showed that death as an outcome was significantly associated with pediatric severe acute respiratory syndrome (SARS) (OR 22.300; 95% CI 2.341-212.421; p=0.007) and multisystem inflammatory syndrome in children (MIS-C) (OR 11.261; 95% CI 1.189-106. 581; p=0.035). CONCLUSIONS: Half of the laboratory-confirmed COVID-19 cases occurred in adolescents. Individuals belonging to this age group had an acute systemic involvement of SARS-CoV-2 infection. Pediatric SARS and MIS-C were the most important factors associated with the mortality rate in pediatric chronic conditions with COVID-19.

https://doi.org/10.6061/clinics/2021/e3488

Increase in the risk of snakebites incidence due to changes in humidity levels: A time series study in four municipalities of the state of Rondônia
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Ferreira, Alex Augusto Ferreira e

; Reis, Valdison Pereira dos

; Boeno, Charles Nunes

; Evangelista, Jaina Rodrigues

; Santana, Hallison Mota

; Serrath, Suzanne Nery

; Lopes, Jéssica Amaral

; Rego, Cristina Matiele Alves

; Tavares, Maria Naiara Macedo

; Paloschi, Mauro Valentino

; Nery, Neriane Monteiro

; Dantas, Alessandra da Silva

; Rodrigues, Moreno Magalhães S.

; Zuliani, Juliana Pavan

Revista da Sociedade Brasileira de Medicina Tropical

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2020, Volume 53 elocation e20190377

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: Snakebites represent a serious global public health problem, especially in tropical countries. In Brazil, the incidence of snakebites ranges from 19 to 22 thousand cases per 100000 persons annually. The state of Rondônia, in particular, has had an increasing incidence of snakebites. METHODS: A retrospective cross-sectional study on snakebites was conducted from January 2007 to December 2018. Brazil’s Information System for Notifiable Diseases was queried for all snakebites reported in Porto Velho, Ariquemes, Cacoal, and Vilhena. Data on land surface temperatures during the day and night, precipitation, and humidity were obtained using the Google Earth Engine. A Bayesian time series model was constructed to describe the pattern of snakebites and their relationship with climate data. RESULTS: In total, 6326 snakebites were reported in Rondônia. Accidents were commonly caused by Bothrops sp. (n=2171, 81.80%). Snakebites most frequently occurred in rural areas (n=2271, 85.5%). Men, with a median age of 34 years (n=2101, 79.1%), were the most frequent bitten. Moderate clinical manifestation was the most common outcome of an accident (n=1101, 41.50%). There were clear seasonal patterns with respect to rainfall, humidity, and temperature. Rainfall and land surface temperature during the day or night did not increase the risk of snakebites in any city; however, changes in humidity increased the risk of snakebites in all cities. CONCLUSION: This study identified the population exposed to snakes and the influence of anthropic and climatic factors on the incidence of snakebites. According to climate data, changes in humidity increased the risk of snakebites.

https://doi.org/10.1590/0037-8682-0377-2019 1306 downloads

RECOMMENDATIONS FOR INVASIVE PROCEDURES IN PATIENTS WITH DISEASES OF THE LIVER AND BILIARY TRACT: REPORT OF A JOINT MEETING OF THE BRAZILIAN SOCIETY OF HEPATOLOGY (SBH), BRAZILIAN SOCIETY OF DIGESTIVE ENDOSCOPY (SOBED) AND BRAZILIAN SOCIETY OF INTERVENTIONAL RADIOLOGY AND ENDOVASCULAR SURGERY (SOBRICE)
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SCHIAVON, Leonardo de Lucca

; EJIMA, Flávio Hayato

; MENEZES, Marcos Roberto de

; BITTENCOURT, Paulo Lisboa

; MOREIRA, Aírton Mota

; FARIAS, Alberto Queiroz

; CHAGAS, Aline Lopes

; ASSIS, André Moreira de

; MATTOS, Ângelo Zambam de

; SALOMÃO, Bruno Chaves

; TERRA, Carlos

; MARTINS, Fernanda Prata Borges

; CARNEVALE, Francisco Cesar

; REZENDE, Guilherme Ferreira da Motta

; PAULO, Gustavo Andrade de

; PEREIRA, Gustavo Henrique Santos

; MOTTA-LEAL-FILHO, Joaquim Maurício da

; MENESES, Juliana de

; COSTA, Lucas Santana Nova da

; CARNEIRO, Marcos de Vasconcelos

; ÁLVARES-DA-SILVA, Mário Reis

; SOARES, Mayra Veloso Ayrimoraes

; PEREIRA, Osvaldo Ignácio

; XIMENES, Rafael Oliveira

; DURANTE, Renata Filardi Simiqueli

; FERREIRA, Valério Alves

; LIMA, Vinícius Machado de

Arquivos de Gastroenterologia

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jun 2019, Volume 56 N. 2 Pages 213 - 231

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As doenças do fígado e das vias biliares são causas comuns de morbidade e mortalidade. Procedimentos invasivos com finalidade diagnóstica e terapêutica são frequentemente recomendados nos casos de doenças hepatobiliares. O reconhecimento das indicações e limitações das técnicas comumente empregadas é crucial para uma adequada seleção dos pacientes, maximizando os resultados positivos e reduzindo o risco de complicações. Em 2018, a Sociedade Brasileira de Hepatologia (SBH), em colaboração com a Sociedade Brasileira de Radiologia Intervencionista e Cirurgia Endovascular (SOBRICE) e a Sociedade Brasileira de Endoscopia Digestiva (SOBED) realizaram um encontro exclusivamente voltado para a discussão dos procedimentos invasivos nas doenças hepatobiliares. Este texto resume as principais recomendações discutidas durante o evento, e tem a intenção de auxiliar clínicos, gastroenterologistas, hepatologistas, radiologistas e endoscopistas no uso adequado dos procedimentos invasivos para manejo de pacientes com doenças hepatobiliares.

ABSTRACT Liver and biliary tract diseases are common causes of morbidity and mortality worldwide. Invasive procedures are usually performed in those patients with hepatobiliary diseases for both diagnostic and therapeutic purposes. Defining proper indications and restraints of commonly used techniques is crucial for proper patient selection, maximizing positive results and limiting complications. In 2018, the Brazilian Society of Hepatology (SBH) in cooperation with the Brazilian Society of Interventional Radiology and Endovascular surgery (SOBRICE) and the Brazilian Society of Digestive Endoscopy (SOBED) sponsored a joint single-topic meeting on invasive procedures in patients with hepatobiliary diseases. This paper summarizes the proceedings of the aforementioned meeting. It is intended to guide clinicians, gastroenterologists, hepatologists, radiologists, and endoscopists for the proper use of invasive procedures for management of patients with hepatobiliary diseases.

https://doi.org/10.1590/s0004-2803.201900000-42 2181 downloads

EVALUATION OF USABILITY OF A NEONATAL HEALTH INFORMATION SYSTEM ACCORDING TO THE USER’S PERCEPTION
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Padrini-Andrade, Lucio

; Balda, Rita de Cássia Xavier

; Areco, Kelsy Catherina Nema

; Bandiera-Paiva, Paulo

; Nunes, Marynéa do Vale

; Marba, Sérgio Tadeu Martins

; Carvalho, Werther Brunow de

; Rugolo, Ligia Maria Suppo de Souza

; Almeida, João Henrique Carvalho de

; Procianoy, Renato Soibelmann

; Duarte, José Luiz Muniz Bandeira

; Rego, Maria Albertina Santiago

; Ferreira, Daniela Marques de Lima Mota

; Alves Filho, Navantino

; Guinsburg, Ruth

; Diniz, Edna Maria de Albuquerque

; Santos, Juliana Paula Ferraz dos

; Testoni, Daniela

; Silva, Nathalia Moura de Mello e

; Gonzales, Maria Rafaela Conde

; Silva, Regina Vieira Cavalcante da

; Meneses, Jucille

; Gonçalves-Ferri, Walusa Assad

; Perussi-e-Silva, Ricardo

; Bomfim, Olga

Revista Paulista de Pediatria

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jan 2019, Volume 37 N. 1 Pages 90 - 96

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Mensurar o grau de satisfação de profissionais de saúde quanto à usabilidade de um sistema de informação em saúde neonatal e identificar os fatores que podem influenciar na satisfação do usuário frente à usabilidade. Métodos: Estudo transversal e exploratório realizado com 50 profissionais de saúde integrantes dos centros da Rede Brasileira de Pesquisas Neonatais. Para avaliação da usabilidade foi utilizado o instrumento System Usability Scale entre fevereiro e março de 2017. Realizou-se a análise estatística descritiva e inferencial das variáveis coletadas, com a finalidade de descrever a amostra, quantificar o grau de satisfação dos usuários e identificar as variáveis associadas ao grau de satisfação do usuário em relação à usabilidade. Resultados: Da população avaliada, 75% era do sexo feminino, com idade média 52,8 anos, 58% com pós-graduação (doutorado); tempo médio da última formação de 17 anos; área de atuação em medicina (neonatologia), grau intermediário de conhecimento em informática e tempo de utilização média do sistema de 52 meses. Quanto à usabilidade, 94% avaliaram o sistema como “bom”, “excelente” ou “melhor impossível”. A usabilidade do sistema não foi associada a idade, sexo, escolaridade, profissão, área de atuação, nível de conhecimento em informática e tempo de uso do sistema. Conclusões: O grau de satisfação do usuário do sistema informatizado de saúde foi considerado bom. Não foram identificados fatores demográficos que influenciassem sua avaliação.

ABSTRACT Objective: To measure the level of satisfaction regarding the usability of a neonatal health information system and identify if demographic factors can influence the usability of a health information system. Methods: A cross-sectional, exploratory study was carried out with a convenience sample of 50 users of the Brazilian Neonatal Research Network. The instrument chosen for the usability evaluation was the System Usability Scale between February and March 2017. The statistical analysis of the collected variables was carried out in order to describe the sample, to quantify the level of satisfaction of the users and to identify the variables associated with the level of satisfaction. Results: The female gender represented 75% of the sample. The mean age was 52.8 years; 58% had a doctoral degree, average time of graduation was 17 years, with area of practice in medicine (neonatology), with intermediate knowledge in computer science (74%) and mean system use time of 52 months. Regarding usability, 94% rated the system as “good”, “excellent” or “better than imaginable”. The usability of the system was not associated with age, gender, education, profession, area of practice, knowledge in computer science and time of system use. Conclusion: The level of satisfaction of the computerized health system user was considered good. No demographic factors were associated with the satisfaction of the users.

https://doi.org/10.1590/1984-0462/;2019;37;1;00019 3877 downloads

Características audiológicas de pacientes com diabetes mellitus Tipo 2
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Ferreira, Juliana Mota

; Câmara, Marília Fontenele e Silva

; Almeida, Paulo César de

; Brandão Neto, José

; Silva, Carlos Antonio Bruno da

Revista CEFAC

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oct 2016, Volume 18 N. 5 Pages 1050 - 1059

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivos: identificar as características audiológicas de pacientes com diabetes mellitus tipo 2. Métodos: estudo transversal, realizado em unidade de atenção secundária para diabetes em Fortaleza, de abril a julho de 2010. Amostra composta por 152 pacientes diabéticos tipo 2, independente do sexo, entre 36 e 60 anos. Realizou-se audiometria tonal liminar (ATL), emissões otoacústicas evocadas por estímulo transiente (EOAT) e emissões otoacústicas evocadas-produto de distorção (EOAPD). Resultados: associação da idade e do tempo de diagnóstico com a presença de perda auditiva, e do tempo de diagnóstico com a ausência de EOAPD. Observou-se perda auditiva sensorioneural em 63,2% dos pacientes, das quais 71,9% eram bilaterais e 75% simétricas. Aproximadamente, 50% das perdas auditivas apresentaram configuração plana. As EOAT estavam ausentes em 75% dos pacientes e as EOAPD em 78,9%. Houve ausência de emissões otoacústicas na presença de ATL normal, em média, em 32% dos pacientes à direita e 48% à esquerda. Já a presença de emissões otoacústicas na ocorrência de perda auditiva foi observada em, aproximadamente, 30% dos pacientes para EOAT e 14% para EOAPD à direita; e 25% para EOAT e 11% para EOAPD à esquerda. Conclusão: predomínio de perda auditiva sensorioneural bilateral simétrica com configuração plana, e ausência de EOAT e EOAPD. A análise da associação dos resultados da ATL e das emissões otoacústicas sugere prejuízo das células ciliadas externas da cóclea ou possível neuropatia auditiva. Tais achados justificariam o monitoramento da audição destes pacientes, bem como a realização de testes específicos para avaliação do sistema auditivo central.

ABSTRACT Purpose: to identify the audiological characteristics of patients with type 2 diabetes mellitus. Methods: Cross-sectional study in secondary care unit for diabetes in Fortaleza, April-July 2010. The sample comprised 152 patients with type 2 diabetes, regardless of sex, between 36 and 60 years of age. Held pure tone audiometry (PTA), transient-evoked otoacoustic emissions (TEOAE) and distortion product otoacoustic emissions (DPOAE). Results: association of age and time of diagnosis with hearing loss, and the time of diagnosis with the absence of DPOAE. It was observed sensorineural hearing loss in 63.2% of patients, which 71.9% were bilateral and 75% symmetric. Approximately 50% of hearing loss had flat configuration. TOAEs were absent in 75% of the patients and DPOAE in 78.9%. There were no otoacoustic emissions in the presence of normal PTA, on average, 32% of the patients on the right and 48% on the left. The presence of otoacoustic emissions on the occurrence of hearing loss was observed in approximately 30% of patients for TEOAE and 14% for DPOAE on the right; and 25% for TEOAE and 11% for DPOAE on the left. Conclusions: Prevalence of symmetrical bilateral sensorineural hearing loss with a flat configuration, and absence of TEOAE and DPOAE. The association analysis of the results of PTA and OAE suggests loss of outer hair cells of the cochlea or possible auditory neuropathy. These findings justify the hearing monitoring of these patients, as well as conducting specific tests to evaluate the central auditory system.

https://doi.org/10.1590/1982-0216201618522415 3314 downloads

10.

Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil
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Almeida, Fabiana Greyce Oliveira

; Aquino, Priscila Ferreira de

; Souza, Afonso Duarte Leäo de

; Souza, Antonia Queiroz Lima de

; Vinhote, Sonia do Carmo

; Mac-Cormick, Thais Messias

; Silva, Marcelo Soares da Mota

; Chalub, Sidney Raimundo Silva

; Fischer, Juliana de Saldanha da Gama

; Carvalho, Paulo Costa

; Carvalho, Maria da Gloria da Costa

Biological Research

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2015, Volume 48 Pages 1 - 6

Abstract: En | Text: En | PDF: En

BACKGROUND: DNA methylation is commonly linked with the silencing of the gene expression for many tumor suppressor genes. As such, determining DNA methylation patterns should aid, in times to come, in the diagnosis and personal treatment for various types of cancers. Here, we analyzed the methylation pattern from five colorectal cancer patients from the Amazon state in Brazil for four tumor suppressor genes, viz.: DAPK, CDH1, CDKN2A, and TIMP2 by employing a polymerase chain reaction (PCR) specific to methylation. Efforts in the study of colorectal cancer are fundamental as it is the third most of highest incidence in the world. RESULTS: Tumor biopsies were methylated in 1/5 (20 %), 2/5 (40 %), 4/5 (80 %), and 4/5 (80 %) for CDH1, CDKN2A, DAPK, and TIMP2 genes, respectively. The margin biopsies were methylated in 3/7 (43 %), 2/7 (28 %), 7/7 (100 %), and 6/7 (86 %) for CDH1, CDKN2A, DAPK, and TIMP2, respectively. CONCLUSIONS: Our findings showed DAPK and TIMP2 to be methylated in most samples from both tumor tissues and adjacent non-neoplastic margins; thus presenting distinct methylation patterns. This emphasizes the importance of better understanding of the relation of these patterns with cancer in the context of different populations.

https://doi.org/10.1186/S40659-015-0042-7 1110 downloads

11.

Alterações auditivas associadas a complicações e comorbidades no diabetes mellitus tipo 2
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Ferreira, Juliana Mota

; Câmara, Marília Fontenele e Silva

; Almeida, Paulo César de

; Brandão Neto, José

; Silva, Carlos Antonio Bruno da

Audiology - Communication Research

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dec 2013, Volume 18 N. 4 Pages 250 - 259

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Investigar a presença de alterações auditivas, representadas por diminuição do limiar audiométrico e/ou ausência de emissões otoacústicas, associadas às características gerais, complicações crônicas e comorbidades em pacientes com diabetes tipo 2. MÉTODOS: Estudo realizado em unidade de atenção secundária, em Fortaleza, de abril a julho de 2010. Amostra de 152 pacientes de 36 a 60 anos de idade, portadores de diabetes tipo 2. Analisou-se dados clínicos relacionados ao diabetes e à avaliação audiológica, composta por audiometria tonal liminar, emissões otoacústicas evocadas por estímulo transiente e emissões otoacústicas evocadas produto de distorção. RESULTADOS: O gênero feminino predominou, com 95 (62,5%) pacientes. A média de idade foi 53,4 anos. Verificou-se perda auditiva sensorioneural em 96 (63,2%) pacientes, sendo a maioria perda coclear (83,3%). Cento e catorze pacientes (75%) apresentaram ausência de emissões transientes e 120 (78,9%), ausência de emissões produto de distorção. Os homens diabéticos demonstraram 4,4 vezes mais chance de perda auditiva que as mulheres. Quanto maior o tempo da doença, maior a probabilidade de perda auditiva. Os pacientes diabéticos acima de 50 anos também apresentaram maior chance para perda auditiva. CONCLUSÃO: Das comorbidades e complicações associadas ao diabetes, o sobrepeso/obesidade constitui fator de risco para alteração auditiva, estando associado à perda auditiva e ausência de emissões transientes. Os pacientes diabéticos com sobrepeso/obesidade apresentaram três vezes mais chances de alterações na audiometria e emissões otoacústicas.

PURPOSE: To investigate the presence of hearing impairment, represented by a decreased audiometric threshold and/ or absence of otoacoustic emissions, associated with general characteristics, chronic complications and comorbidities in patients with type 2 diabetes. METHODS: The study was carried out a secondary care unit in Fortaleza, from April to July 2010, using a sample of 152 patients aged 36 to 60 with type 2 diabetes. The clinical data related to diabetes was analyzed and an audiological evaluation consisting of pure tone audiometry, otoacoustic emissions elicited by transient stimuli and distortion. RESULTS: The female gender predominated, with 95 (62.5%) patients. The mean age was 53.4 years. Sensorineural hearing loss was found in 96 (63.2%) patients, mainly cochlear loss (83.3%). 114 patients (75%) had an absence of transient emissions, and 120 (78.9%), had an absence of distortion product emissions. Diabetic men had a 4.4 times greater chance of hearing loss than women. The longer the disease time the greater the chance of hearing loss. Diabetic patients over 50 years old were also more likely to have hearing loss. CONCLUSION: Of the comorbidities and complications associated with diabetes, overweight/obesity was a risk factor for auditory alterations and is associated with hearing loss and the absence of transient emissions. Overweight/obese diabetic patients were 3 times more likely to have impaired audiometry and otoacoustic emissions.

5317 downloads

12.

Effect of green propolis on oral epithelial dysplasia in rats
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Cavalcante, Danielle Rodrigues Ribeiro

; Oliveira, Paula Santos de

; Góis, Sandro Mota

; Soares, Andréa Ferreira

; Cardoso, Juliana Cordeiro

; Padilha, Francine Ferreira

; Albuquerque Júnior, Ricardo Luiz Cavalcanti de

Brazilian Journal of Otorhinolaryngology

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jun 2011, Volume 77 N. 3 Pages 278 - 284

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Estudos têm demonstrado que componentes hidrossolúveis da própolis verde, flavonóides, apresentam atividade antitumoral. FORMA DE ESTUDO: Estudo experimental. OBJETIVO: Avaliar o efeito do extrato hidroalcoólico de própolis verde (EPV) sobre displasias epiteliais linguais quimicamente induzidas em ratos. MATERIAIS E MÉTODOS: Neste estudo, foi pincelado DMBA (9,10-dimetil-1,2- benzatraceno) no dorso lingual de ratos 3x/semana, em dias alternados, administrado 100 (PROP1), 200 (PROP2) e 300 mg/kg (PROP3) de EPV (v.o.), durante 20 semanas. A substituição do EPV ou DMBA pelos seus veículos foi usada nos controles positivos (TUM1 e TUM2), negativos (CTR1 e CTR2), respectivamente. O epitélio lingual foi analisado histologicamente, graduado pelo Sistema Binário e classificação OMS, e os dados comparados por análise de variância (ANOVA) (p<0,05). RESULTADOS: O rendimento do EPV foi 41,43% e o teor de flavonóides 0,95±0,44%. Segundo o Sistema Binário, TUM1, TUM2 e PROP1 foram considerados lesões de alto risco, apresentando índices de alterações morfológicas significativamente mais elevados (p<0,05), e os demais de baixo risco. Segundo a classificação OMS, observou-se displasia moderada em TUM e TUM2, leve em PROP1, PROP2 e PROP3, e ausente em CTR1 e CTR2. Conclusão: Sugere-se que o EPV possa desempenhar um papel protetor importante durante a carcinogênese lingual quimicamente induzida em ratos. CONCLUSÃO: Sugere-se que o EPV possa desempenhar um papel protetor importante durante a carcinogênese lingual quimicamente induzida em ratos.

Studies have demonstrated that flavonoid compounds of green propolis have antitumoral activity. STUDY DESIGN: Experimental study. AIMS: To evaluate the effect of a hydroalcoholic extract of green propolis (EPV) on chemically induced epithelial dysplasias in rat tongues. METHODS AND MATERIALS: DMBA was brushed on the lingual dorsum of rats 3x/week on alternate days - 100 (PROP1), 200 (PROP2) and 300 mg/kg (PROP3) EPV was administered orally for 20 weeks. EPV or DMBA were replaced by their vehicles and applied as positive (TUM1 and TUM2) and negative controls (CTR1 and CTR2), respectively. The lingual epithelium was histologically analyzed and graded according a binary system and the WHO classification; the data were compared using ANOVA (*p<0.05). RESULTS: The EPV yield was 41% and the flavonoid yield was 0.95±0.44%. According to the Binary System, TUM1, TUM2 and PROP1 were considered high risk lesions, with significantly higher morphological alteration rates compared to the other groups (p<0.05), which were considered low risk lesions. Based on the WHO classification, moderate dysplasia was TUM1 and TUM2, mild dysplasia was PROP1, PROP2 and PROP3, and non-dysplastic epithelium was CTR1 and CTR2. CONCLUSION: EPV seems to play an important protective role against chemically-induced lingual carcinogenesis in rats.

5924 downloads

13.

Perfil audiológico de pacientes com diabetes mellitus tipo II
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Ferreira, Juliana Mota

; Sampaio, Fernanda Mônica de Oliveira

; Coelho, Joyce Monte Silva

; Almeida, Nádia Maria Girão Saraiva de

Revista da Sociedade Brasileira de Fonoaudiologia

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dec 2007, Volume 12 N. 4 Pages 292 - 297

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVO: Pacientes acometidos por Diabetes Mellitus (DM) do tipo II constituem uma população de risco para alterações auditivas, uma vez que alterações metabólicas podem afetar tecidos nervosos e vasculares, que atingem diretamente os órgãos responsáveis pela audição. O presente estudo buscou investigar o perfil audiológico de pacientes com DM do tipo II. MÉTODOS: Foi realizado um estudo descritivo, no qual foram avaliados 44 sujeitos (88 orelhas). A população selecionada encontrava-se na faixa etária de 25 a 65 anos de idade. Todos os sujeitos realizaram avaliação audiológica, sendo submetidos a audiometria tonal liminar, audiometria vocal e imitância acústica. RESULTADOS: A prevalência de pacientes com DM do tipo II foi maior no sexo feminino (77,3%). Trinta e um (70,4%) pacientes apresentavam DM tipo do II a um período inferior a 10 anos. Trinta e três orelhas (37,5%) apresentaram perda auditiva neurossensorial de grau leve ou moderado, com predomínio em freqüências altas. Na imitância acústica, 71 orelhas (80,7%) apresentaram curva do tipo A, e 83 orelhas (94,3%) tiveram presença de reflexo estapediano. CONCLUSÃO: Observou-se a ocorrência de perda auditiva em pacientes portadores de DM do tipo II, conseqüentemente, a avaliação audiológica desses pacientes é importante para o acompanhamento das alterações auditivas.

PURPOSE: People that suffer from Diabetes Mellitus (DM) type II constitute a risk population for hearing disorders, since metabolic disease can affect nerve and vascular tissues that attain directly the auditory system. The present study investigated the audiologic profile of patients with DM type II. METHODS: A descriptive study was carried out, where 44 patients (88 ears) were evaluated. The ages of the subjects ranged from 25 to 65 years. All subjects underwent an audiological evaluation that included pure tone audiometry, speech audiometry and acoustic immittance measures. RESULTS: The prevalence of patients with DM type II was higher among female (77.3%). Thirty one (70.4%) patients had DM type II for less than 10 years. Thirty three ears (37.5%) had sensorineural hearing loss ranging from low to moderate degree, predominantly in high frequencies. In the acoustic immittance measures, 71 (80,7%) ears showed type A tympanograms and 83 (94,3%) ears had presence of acoustic reflex. CONCLUSION: The occurrence of hearing loss was observed in patients with DM type II; consequently, the auditory evaluation of these patients is important to the follow up of the hearing loss.

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