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Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19. COVID19 COVID 19 COVID-1 doença escassos COVID19. 19. COVID19, 19, 3 cidades 2020 invasivo robusta p005 p 0 05 p<0,05 292 idade 6 4871, 4871 48 71 , (48-71) 57,1%, 571 57,1% 57 57,1%] 273 27 27,3 12 (1-2 vs 020. 020 20 . (0-20)] cerebral desidrogenase fosfoquinase Nterminal N terminal própeptídeo pró independentes RR 203 03 2,03 IC95 IC 1,602,58 160258 1,60 2,58 58 1,60-2,58 1,87IC95% 187IC95 1,87 87 1,87;IC95 1,572,23, 157223 1,57 2,23 23 1,57-2,23) normais COVID1 COVID- 202 p00 p<0,0 29 487 4 7 (48-71 57,1 5 27, (1- 02 (0-20) 2,0 IC9 602 1,602,5 16025 160 1,6 258 2,5 1,60-2,5 87IC95 1,87IC95 187IC9 187 1,8 8 1,87;IC9 572 1,572,23 15722 157 1,5 223 2,2 1,57-2,23 p0 p<0, (48-7 57, (1 (0-20 2, 1,602, 1602 16 1, 25 1,60-2, 87IC9 1,87IC9 187IC 18 1,87;IC 1,572,2 1572 15 22 1,57-2,2 p<0 (48- ( (0-2 1,602 1,60-2 87IC 1,87IC 1,572, 1,57-2, p< (48 (0- 1,60- 1,572 1,57-2 (4 (0 1,57-

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients. COVID19 COVID 19 COVID-1 diseases disease s prognosis scarce inhospital hospital Registry 3 cities MarchSeptember March September 2020 variance p005 p 0 05 p<0.05 2925 925 2,92 6 4871, 4871 48 71 , [48-71] 571 57 57.1 men, men men) 273 27 27.3 12 [1-2 vs 02. 02 . [0-2]) peptide dehydrogenase phosphokinase Nterminal N terminal probrain pro Creactive C reactive predictors RR 203 03 2.03 95 1.602.58 160258 1.60 2.58 58 1.60-2.58 187 87 1.87 1.572.23, 157223 1.57 2.23 23 1.57-2.23) COVID1 COVID- 202 p00 p<0.0 292 92 2,9 487 4 7 [48-71 5 57. 27. [1- [0-2] 20 2.0 9 602 1.602.5 16025 160 1.6 258 2.5 1.60-2.5 18 8 1.8 572 1.572.23 15722 157 1.5 223 2.2 1.57-2.23 p0 p<0. 29 2, [48-7 [1 [0-2 2. 1.602. 1602 16 1. 25 1.60-2. 1.572.2 1572 15 22 1.57-2.2 p<0 [48- [ [0- 1.602 1.60-2 1.572. 1.57-2. p< [48 [0 1.60- 1.572 1.57-2 [4 1.57-

https://doi.org/10.36660/abc.20220151

Knowledge, attitudes and practices related to sexually transmitted infections of men in prison
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Oliveira, Josias Alves de

; Sousa, Anderson Reis de

; Almeida, Lílian Conceição Guimarães de

; Araújo, Isabella Félix Meira

; Santos, Ailton da Silva

; Bispo, Tania Christiane Ferreira

; Pereira, Álvaro

Revista Brasileira de Enfermagem

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2022, Volume 75 elocation e20201273

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivos: analisar os conhecimentos, as atitudes e práticas relacionadas às infecções sexualmente transmissíveis de homens em situação prisional. Métodos: estudo qualitativo, baseado na metodologia Conhecimento, Atitude e Prática, realizado com 30 homens em situação prisional. Aplicou-se entrevista individual submetida à Análise do Discurso. Resultados: o conhecimento incipiente dos homens esteve associado ao: adoecimento próprio e do outro, diagnóstico e percepção do comportamento de risco, perpassado pela desconfiança ou não entendimento do teste rápido para detecção. As atitudes envolveram culpabilização das parcerias; não adesão aos insumos de prevenção; resistência na procura por serviços de saúde. As práticas vinculam-se ao cuidado à saúde após a identificação da doença, uso de preservativo peniano e cuidado com as parcerias. Conclusões: o reduzido conhecimento sobre Infecções Sexualmente Transmissíveis torna as atitudes estereotipadas, estigmatizadas, comprometidas pelo nível de instrução. As práticas são fragilizadas pelo nível de assistência à saúde e pelos limites da privação de liberdade.

ABSTRACT Objectives: to analyze the knowledge, attitudes, and practices related to sexually transmitted infections of men in prison. Methods: qualitative study, based on the methodology Knowledge, Attitude and Practice, conducted with 30 men in prison. The study applied individual interviews submitted to the analyze of the discourse. Results: the incipient knowledge of men was associated with: self-illness and the others’, diagnosis, and perception of risk behavior, pervaded by distrust or lack of understanding of the rapid test for detection. The attitudes involved culpability of partnerships, non-adherence to prevention inputs, and resistance to look for health services. The practices are linked to health care after the identification of the disease, use of penile condoms, and attention to the partnership. Conclusions: the reduced knowledge about Sexually Transmitted Infections makes attitudes stereotyped, stigmatized, compromised by the level of education. The level of health care and the limits of deprivation of liberty weaken the practices.

RESUMEN Objetivos: analizar conocimientos, actitudes y prácticas relacionadas a enfermedades de transmisión sexual de hombres en situación de prisión. Métodos: estudio cualitativo, basado en la metodología Conocimiento, Actitud y Práctica, realizado con 30 hombres de la prisión. Aplicada entrevista individual sometida a Análisis del Discurso. Resultados: el conocimiento incipiente de los hombres estuvo relacionado a: propia enfermedad y del otro, diagnóstico y percepción de conducta de riesgo, pasado por desconfianza o no entendimiento del test rápido para detección. Las actitudes envolvieron culpabilización de parejas; no adhesión a insumos de prevención; resistencia a búsqueda por servicios de salud. Las prácticas se vinculan al cuidado de salud tras identificación de la enfermedad, uso de preservativo peniano y cuidado con las parejas. Conclusiones: el reducido conocimiento sobre Infecciones de Transmisión Sexual vuelve las actitudes estereotipadas, estigmatizadas, comprometidas por nivel de instrucción. Las prácticas son debilitadas por nivel de asistencia de salud y límites de privación de libertad.

https://doi.org/10.1590/0034-7167-2020-1273

Uso da anticoncepção de emergência entre mulheres usuárias de Unidades Básicas de Saúde em três capitais brasileiras
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Borges, Ana Luiza Vilela

; Gonçalves, Renata Ferreira Sena

; Chofakian, Christiane Borges do Nascimento

; Nascimento, Natália de Castro

; Figueiredo, Regina Maria Mac Dowell de

; Fujimori, Elizabeth

; Santos, Osmara Alves dos

; Divino, Eveline Do Amor

Ciência & Saúde Coletiva

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2021, Volume 26 Suppl. 2 Pages 3671 - 3682

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Pouco se sabe sobre o uso da anticoncepção de emergência entre mulheres de diferentes regiões do país. Este estudo analisou o uso da anticoncepção de emergência e os aspectos associados, bem como o uso de métodos contraceptivos antes e após. Trata-se de estudo transversal, conduzido com 2.051 mulheres de 18-49 anos, usuárias de 76 Unidades Básicas de Saúde de São Paulo-SP, Aracaju-SE e Cuiabá-MT. Os aspectos associados ao uso da anticoncepção de emergência foram analisados por meio de regressão logística múltipla. Mais da metade das mulheres relatou já ter usado a anticoncepção de emergência (56,7%). Ter alta escolaridade, ser de grupo socioeconômico mais favorecido, ter trabalho remunerado e ter tido quatro ou mais parceiros sexuais associou-se com uso de anticoncepção de emergência. Ter 35 anos de idade ou mais e estar em união estável associou-se negativamente. Da última vez que usaram a anticoncepção de emergência, 53,2% usavam outro método, sendo preservativo masculino e pílula oral os mais frequentes. Das que não usavam método, metade adotou método regular após o uso (51,7%). Conclui-se que a anticoncepção de emergência é amplamente utilizada e parece não contribuir para interrupção do método contraceptivo de uso regular.

Abstract Little is known regarding the use of emergency contraception among women from different regions of Brazil. The use of emergency contraception as well as contraceptive methods before and after coitus was analyzed. This cross-sectional study assessed the use of emergency contraception by interviewing 2,051 women aged between 18 and 49 attending 76 basic health units in three capitals: São Paulo-SP, Aracaju-SE and Cuiabá-MT. Aspects associated with the use of emergency contraception were analyzed by means of multiple logistic regression. Over half of the women reported the use of emergency contraception (56.7%). Having a high level of education, being from a more privileged socioeconomic group, having a paid job and having had four or more sexual partners were associated with the use of emergency contraception. Being 35 years of age or older and being in a stable relationship was negatively associated. The last time they used emergency contraception, 53.2% used another method, with the male condom and oral pill being the most frequent. Of those who did not use the method, half adopted the regular method after using it (51.7%). The conclusion drawn is that emergency contraception is widely used and does not appear to affect the use of the regular contraceptive method.

https://doi.org/10.1590/1413-81232021269.2.32772019

Uso da anticoncepção de emergência entre mulheres usuárias de Unidades Básicas de Saúde em três capitais brasileiras
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Borges, Ana Luiza Vilela

; Gonçalves, Renata Ferreira Sena

; Chofakian, Christiane Borges do Nascimento

; Nascimento, Natália de Castro

; Figueiredo, Regina Maria Mac Dowell de

; Fujimori, Elizabeth

; Santos, Osmara Alves dos

; Divino, Eveline Do Amor

Ciência & Saúde Coletiva

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2021, Volume 26 Suppl. 2 Pages 3671 - 3682

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021269.2.32772019 155 downloads

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 N. 1 elocation e20200452

Abstract: En | Text: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

Detecting the extent of control over selection bias relating to oral health and otorhinolaryngology: cross-sectional study
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Ferreira, Christiane Alves

; Atallah, Álvaro Nagib

; Loureiro, Carlos Alfredo de Salles

Sao Paulo Medical Journal

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jun 2020, Volume 138 N. 3 Pages 184 - 189

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: The authors of randomized controlled trials will usually claim that they have met the randomization process criterion. However, sequence generation schemes differ and some schemes that are claimed to be randomized are not genuinely randomized. Even less well understood, and often more difficult to ascertain, is whether the allocation was really concealed. OBJECTIVE: To detect the extent of control over selection bias, in a comparison between two Cochrane groups: oral health and otorhinolaryngology; and to describe the methods used to control for this bias. DESIGN AND SETTING: Cross-sectional study conducted in a public university in São Paulo, Brazil. METHODS: The risk of selection bias in 1,714 records indexed in Medline database up to 2018 was assessed, independent of language and access. Two dimensions implicated in the allocation were considered: generation of the allocation sequence; and allocation concealment. RESULTS: We included 420 randomized controlled trials and all of them were evaluated to detect selection bias. In the sample studied, only 28 properly controlled the selection bias. Lack of control over selection bias was present in 80% of the studies evaluated in both groups. CONCLUSION: The two groups were similar regarding control over selection bias. They are also similar to the methods used. The dimension of allocation concealment appears to be a limiting factor with regard to production of randomized controlled trials with low risk of selection bias. The quality of reporting in studies on oral health and otorhinolaryngology is suboptimal and needs to be improved, in line with other fields of healthcare.

https://doi.org/10.1590/1516-3180.2019.0458.r1.04022020 507 downloads

McConnell patellar taping on postural control of women with patellofemoral pain syndrome: randomized clinical trial
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Ferreira, Daiene Cristina

; Silva Junior, Rubens Alexandre da

; Araújo, Cynthia Gobbi Alves

; Mantovani, Paula Renata

; Macedo, Christiane de Souza Guerino

Fisioterapia em Movimento

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2020, Volume 33 elocation e003357

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: Os efeitos do taping patelar de McConnell (TPM) para o controle postural de mulheres com síndrome da dor patelofemoral (SDPF) são controversos. Objetivo: Avaliar os efeitos do TPM no controle postural estático unipodal e agachamento unipodal em mulheres com SDPF. Método: O estudo é um ensaio clínico randomizado-cego, que avaliou 40 mulheres com SDPF, e idade entre 18 e 35 anos. A amostra foi randomizada em dois grupos: grupo taping patelar de McConnell (GTPM) e grupo placebo (GP). Avaliou-se o controle postural em apoio estático e agachamento unipodal, no membro inferior com SDPF. O deslocamento do centro de pressão (CoP) foi registrado por plataforma de força, e analisado com os testes ANOVA two way e tamanho do efeito (Cohen’s d). Resultados: O controle postural estático não apontou diferenças significativas entre os grupos, tempos ou interação (P> 0,05); com pequeno tamanho de efeito. O controle postural em agachamento unipodal apresentou menor oscilação do centro de pressão para os dois grupos, com diferenças significativas em relação ao tempo de intervenção. No entanto, somente o GTPM demonstrou grande tamanho de efeito na frequência de oscilação e médio tamanho de efeito na velocidade de oscilação, durante o agachamento unipodal. Conclusão: O TPM e o placebo melhoraram o controle postural durante o agachamento unipodal. Deve-se observar que as mudanças e os tamanhos de efeito determinados para o GTPM foram significativamente maiores em relação ao GP, enfatizando sua importância clínica no tratamento de indivíduos com SDPF, durante atividades dinâmicas.

Abstract Introduction: The effects of McConnell patellar taping on the postural control of women with patellofemoral pain syndrome (PFPS) are controversial. Objective: To evaluate the effects of McConnell patellar taping on the static one-leg stance postural control and during squatting in women with PFPS. Method: A randomized, blinded clinical trial that comprised 40 women with PFPS, aged between 18 and 35 years. The study sample was allocated to two groups: McConnell patellar taping group (MPTG) and Placebo taping group (PTG). The analysis included the one-leg static support and squat on the lower limb with PFPS. The center of pressure (CoP) displacement parameters recorded by a force platform were analyzed using two-way ANOVA and Cohen’s d. Results: For the static postural control, no significant differences were found between the groups in terms of time or interaction (p>0.05); with small effect size. For the postural control during the one-leg squat, significant differences were found regarding the time of intervention for both groups, with reduced CoP parameters after the application of taping. However, the MPTG demonstrated a large effect size in frequency of oscillation and medium effect size in speed of oscillation, both during the squat exercise. Conclusion: McConnell patellar taping and placebo taping improved postural control during the one-leg squat. It should be observed that the changes and effect sizes determined for the MPTG were significantly higher compared to the PTG, emphasizing its clinical importance in the treatment of individuals with PFPS, during dynamic activities.

https://doi.org/10.1590/1980-5918.033.ao57 880 downloads

Brazilian Nursing Process Research Network contributions for assistance in the COVID-19 pandemic
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Barros, Alba Lúcia Bottura Leite de

; Silva, Viviane Martins da

; Santana, Rosimere Ferreira

; Cavalcante, Agueda Maria Ruiz Zimmer

; Vitor, Allyne Fortes

; Lucena, Amália de Fatima

; Napoleão, Anamaria Alves

; Lopes, Camila Takao

; Primo, Cândida Caniçali

; Carmona, Elenice Valentim

; Duran, Erika Christiane Marocco

; Butcher, Howard Karl

; Lopes, Juliana de Lima

; Díaz, Leidy Johanna Rueda

; Cubas, Marcia Regina

; Brandão, Marcos Antônio Gomes

; Lopes, Marcos Venícios de Oliveira

; Nóbrega, Maria Miriam Lima da

; Almeida, Miriam de Abreu

; Souza, Priscilla Alfradique de

; Butcher, Rita de Cassia Gengo e Silva

; Jensen, Rodrigo

; Silva, Rudval Souza da

; Morais, Sheila Coelho Ramalho Vasconcelos

; Chianca, Tania Couto Machado

; Santos, Vinicius Batista

Revista Brasileira de Enfermagem

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2020, Volume 73 elocation e20200798

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: descrever o processo de construção teórica dos documentos de apoio ao Processo de Enfermagem nos cenários de atendimento à COVID-19. Métodos: trata-se de um relato de experiência da atividade conjunta da Rede de Pesquisa em Processo de Enfermagem, formada por pesquisadores de Instituições de Ensino Superior e de Saúde do Brasil. Resultados: cinco instrumentos foram organizados coletivamente, envolvendo os elementos da prática de enfermagem (diagnósticos, resultados e intervenções de enfermagem) na assistência à comunidade; ao paciente (suspeito ou com COVID-19 leve e moderada, crítico e residente em Instituições de Longa Permanência para Idosos); e ao suporte à saúde do trabalhador de enfermagem, subsidiando igualmente o registro e a documentação durante a pandemia de COVID-19. Considerações finais: valorizar os fenômenos manifestados por famílias/comunidades, pacientes e profissionais de saúde é essencial para sua identificação precoce, intervenção e prevenção de agravos.

ABSTRACT Objective: to describe the theoretical construction process of nursing process support documents in COVID-19 care scenarios. Methods: an experience report of the joint activity of the Brazilian Nursing Process Research Network (Rede de Pesquisa em Processo de Enfermagem) composed of Higher Education and Health Institution researchers in Brazil. Results: five instruments were organized collectively, involving the elements of nursing practice (nursing diagnoses, outcomes and interventions) in assistance for community; for patients (with suspected or mild, moderate, and critical COVID-19 and residents in Nursing Homes); for nursing workers’ health support, also subsidizing registration and documentation during the COVID-19 pandemic. Final considerations: valuing the phenomena manifested by families/communities, patients and health professionals is essential for early detection, intervention, and prevention of diseases.

RESUMEN Objetivo: describir el proceso de construcción teórica de los documentos de respaldo del Proceso de Enfermería en los escenarios de asistencia al COVID-19. Métodos: es un relato de experiencia de la actividad conjunta de la Red de Investigación de Procesos de Enfermería, formada por investigadores de las Instituciones de Educación Superior y Salud de Brasil. Resultados: se organizaron cinco instrumentos de manera colectiva, involucrando elementos de la práctica de enfermería (diagnósticos, resultados e intervenciones de enfermería) en el cuidado comunitario; al paciente (sospechoso o con COVID-19 leve y moderado, crítico y residente en Hogares para Ancianos); y apoyo a la salud del trabajador de enfermería, subsidiando además el registro y documentación durante la pandemia de COVID-19. Consideraciones finales: valorar los fenómenos manifestados por las familias/comunidades, pacientes y profesionales de la salud es fundamental para su identificación temprana, intervención y prevención de enfermedades.

https://doi.org/10.1590/0034-7167-2020-0798 5348 downloads

Brazilian Nursing Process Research Network contributions for assistance in the COVID-19 pandemic
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Barros, Alba Lúcia Bottura Leite de

; Silva, Viviane Martins da

; Santana, Rosimere Ferreira

; Cavalcante, Agueda Maria Ruiz Zimmer

; Vitor, Allyne Fortes

; Lucena, Amália de Fatima

; Napoleão, Anamaria Alves

; Lopes, Camila Takao

; Primo, Cândida Caniçali

; Carmona, Elenice Valentim

; Duran, Erika Christiane Marocco

; Butcher, Howard Karl

; Lopes, Juliana de Lima

; Díaz, Leidy Johanna Rueda

; Cubas, Marcia Regina

; Brandão, Marcos Antônio Gomes

; Lopes, Marcos Venícios de Oliveira

; Nóbrega, Maria Miriam Lima da

; Almeida, Miriam de Abreu

; Souza, Priscilla Alfradique de

; Butcher, Rita de Cassia Gengo e Silva

; Jensen, Rodrigo

; Silva, Rudval Souza da

; Morais, Sheila Coelho Ramalho Vasconcelos

; Chianca, Tania Couto Machado

; Santos, Vinicius Batista

Revista Brasileira de Enfermagem

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2020, Volume 73 Suppl. 2 elocation e20200798

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

https://doi.org/10.1590/0034-7167-2020-0798 108 downloads

10.

Bio-behavioral survey of syphilis in homeless men in Central Brazil: a cross-sectional study
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Barros, Cleiciane Vieira de Lima

; Galdino Júnior, Hélio

; Rezza, Giovanni

; Guimarães, Rafael Alves

; Ferreira, Priscilla Martins

; Souza, Christiane Moreira

; Guimarães, Lara Cristina da Cunha

; Barros, David Antônio Costa

; Brunini, Sandra Maria

Cadernos de Saúde Pública

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2018, Volume 34 N. 6 elocation e00033317

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O estudo teve como objetivo investigar a prevalência da sífilis e fatores associados em homens sem-teto no Centro-oeste do Brasil. A amostra nesse estudo transversal incluiu 481 indivíduos que frequentavam comunidades terapêuticas entre outubro e dezembro de 2015. Uma entrevista estruturada foi usada para coletar dados sociodemográficos e fatores de risco para sífilis. Foram realizados testes rápidos e VDRL para determinar a exposição à sífilis e a presença de sífilis ativa, respectivamente. A análise de regressão de Poisson foi usada para verificar os fatores de risco associados aos desfechos investigados. Entre os participantes, 10,2% foram reativos ao teste rápido e 5,4% tinham sífilis ativa. Na análise de regressão múltipla, a escolaridade (razão de prevalência ajustada - RPA: 0,89; p = 0,005), história de úlcera genital (RPA: 2,59; p = 0,002), história de DST (RPA: 1,97; p = 0,042) e relações sexuais sob o efeito de drogas (RPA: 1,60; p = 0,022) apareceram como fatores independentes associados à história pregressa de sífilis. Além disso, a história de úlcera genital (RPA: 2,19; p = 0,019), história de DST (RPA: 1,74; p = 0,033) e número de parceiros sexuais no último ano (RPA: 1,02; p = 0,044) estiveram associados à sífilis ativa. A prevalência de sífilis em homens sem-teto era bastante elevada, confirmando a vulnerabilidade desse grupo à infecção. Os achados enfatizam a necessidade de intervenções educacionais, melhoria dos programas de redução de risco, disponibilidade de testes diagnósticos (sobretudo o teste rápido) e tratamento adequado.

The objective of this study was to investigate the prevalence and factors associated with syphilis in homeless men in Central Brazil. It is a cross-sectional study conducted with 481 individuals attending four therapeutic communities between October and December 2015. A structured interview was conducted to collect sociodemographic data and risk factors for syphilis. Rapid/point-of-care and VDRL tests were performed to determine exposure to syphilis and the presence of active syphilis, respectively. Poisson regression analysis was used to verify the risk factors associated with the outcomes investigated. Of the study participants, 10.2% were reactive to the rapid test, and 5.4% had active syphilis. At the multiple regression analysis, schooling (adjusted prevalence ratio - APR: 0.89; p = 0.005), history of genital ulcer (APR: 2.59; p = 0.002), STI history (APR: 1.97; p = 0.042), and sexual intercourse under drug effects (APR: 1.60; p = 0.022) were independent factors associated with lifetime syphilis. Also, history of genital ulcer (APR: 2.19; p = 0.019), STI history (APR: 1.74; p = 0.033) and number of sexual partners in the last year (APR: 1.02; p = 0.044) were associated with active syphilis. The prevalence of syphilis among homeless men was rather high, confirming the vulnerability of this group to this infection. These results emphasize the need for educational intervention, improvement of risk reduction programs, availability of diagnostic tests, especially the rapid test, and treatment.

El objetivo de este estudio fue investigar la prevalencia y los factores asociados con la sífilis en hombres sin techo en el Centro-oeste de Brasil. Se trata de un estudio transversal, llevado a cabo con 481 personas que asistían a cuatro comunidades terapéuticas entre octubre y diciembre de 2015. La entrevista estructurada se realizó con el fin de recabar datos sociodemográficos y factores de riesgo para la sífilis. Se realizaron pruebas de diagnóstico rápido y serológicas para la sífilis (VDRL por sus siglas en inglés) para determinar la exposición a la sífilis y la presencia de sífilis activa, respectivamente. Se usó el análisis por regresión de Poisson para verificar los factores de riesgo asociados con los resultados investigados. Entre los participantes en el estudio, un 10,2% fueron reactivos a las pruebas de diagnóstico rápido, y un 5,4% tenían sífilis activa. En el análisis de regresión múltiple, la escolarización (la razón de prevalencia ajustada - APR: 0,89; p = 0,005), un historial de úlcera genital (APR: 2,59; p = 0,002), un historial de ETS (APR: 1,97; p = 0,042), e intercambios sexuales bajo los efectos de las drogas (APR: 1,60; p = 0,022) fueron factores independientes asociados con la sífilis a lo largo de la vida. Asimismo, un historial de úlcera genital (APR: 2,19; p = 0,019), un historial de ETS (APR: 1,74; p = 0,033) y el número de parejas de índole sexual en el último año (APR: 1,02; p = 0,044) estuvieron asociados con sífilis activa. La prevalencia de sífilis entre los hombres sin techo fue bastante alta, confirmando la vulnerabilidad de este grupo a la infección. Estos resultados enfatizan la necesidad de intervenciones educativas, así como una mejora en los programas de reducción del riesgo, disponibilidad de pruebas de diagnóstico, especialmente pruebas rápidas, y tratamiento.

https://doi.org/10.1590/0102-311x00033317 53 downloads

11.

Bio-behavioral survey of syphilis in homeless men in Central Brazil: a cross-sectional study
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Barros, Cleiciane Vieira de Lima

; Galdino Júnior, Hélio

; Rezza, Giovanni

; Guimarães, Rafael Alves

; Ferreira, Priscilla Martins

; Souza, Christiane Moreira

; Guimarães, Lara Cristina da Cunha

; Barros, David Antônio Costa

; Brunini, Sandra Maria

Cadernos de Saúde Pública

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2018, Volume 34 N. 6 elocation e00033317

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00033317 1928 downloads

12.

Greater expression of the human leukocyte antigen-G (HLA-G) and interleukin-17 (IL-17) in cervical intraepithelial neoplasia: analytical cross-sectional study
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Miranda, Lidyane Neves

; Reginaldo, Fernanda Priscila Santos

; Souza, Daliana Maria Berenice Oliveira

; Soares, Christiane Pienna

; Silva, Tarsia Giabardo Alves

; Rocha, Keyla Borges Ferreira

; Jatobá, Carlos André Nunes

; Donadi, Eduardo Antonio

; Andrade, Joanlise Marco Leon

; Gonçalves, Ana Katherine Silveira

; Crispim, Janaína Cristiana Oliveira

Sao Paulo Medical Journal

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aug 2015, Volume 133 N. 4 Pages 336 - 342

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

CONTEXTO E OBJETIVO:A deficiência na imunidade celular localizada parece contribuir para a patogênese e progressão das neoplasias intraepiteliais cervicais (NIC), no entanto, ainda não está totalmente esclarecido o mecanismo molecular fundamental nesse processo de progressão. A identificação de novos marcadores moleculares de prognóstico e diagnóstico das NIC em estágios precoces pode ajudar a diminuir a quantidade de casos de NIC. Várias novas moléculas com função imunorregulatória foram descobertas nos últimos anos, inclusive o antígeno leucocitário humano G (HLA-G), que, através de interação com os receptores, tem importantes funções tolerogênicas. Diversas linhas de evidência sugerem que as células T-ajudantes produtoras de interleucina-17 (IL-17, células Th17), podem desempenhar um papel na imunidade antitumoral. Porém, recentes relatos implicaram as células Th17 e suas citocinas tanto em processos pro- quanto anti-tumorigênicos. O objetivo do estudo foi avaliar o papel do HLA-G e Th17 na imunopatogênese das NIC I.TIPO DE ESTUDO E LOCAL:Estudo transversal analítico com grupo controle em 58 espécimes cervicais dos arquivos de um hospital universitário público com assistência prestada no nível terciário.MÉTODOS:Avaliamos a expressão de HLA-G e IL-17 por imunoistoquímica no microambiente cervical, associando esses achados com as características clínico-patológicas.RESULTADOS:Houve tendência aumentada da expressão de HLA-G e IL-17 em espécimes que apresentaram NIC I, sugerindo que essas moléculas têm contribuição na progressão cervical.CONCLUSÃO:Estes resultados sugerem que a expressão do HLA-G e da IL-17 pode ser um marcador precoce para avaliar a progressão das lesões cervicais.

CONTEXT AND OBJECTIVE:Impaired local cell immunity seems to contribute towards the pathogenesis and progression of cervical intraepithelial neoplasia (CIN), but the underlying molecular mechanisms promoting its progression remain unclear. Identification of new molecular markers for prognosis and diagnosis of early-stage CIN may aid in decreasing the numbers of CIN cases. Several novel immunoregulatory molecules have been discovered over the past few years, including the human leukocyte antigen G (HLA-G), which through interaction with its receptors exerts important tolerogenic functions. Several lines of evidence suggest that T-helper interleukin-17 (IL-17)-producing cells (Th17 cells) may play a role in antitumor immunity. However, recent reports have implicated Th17 cells and their cytokines in both pro and anti-tumorigenic processes. The aim of the study was to evaluate the roles of HLA-G and Th17 in the immunopathogenesis of CIN I.DESIGN AND SETTING:Analytical cross-sectional study with a control group using 58 cervical specimens from the files of a public university hospital providing tertiary-level care.METHODS:We examined HLA-G and IL-17 expression in the cervical microenvironment by means of immunohistochemistry, and correlated these findings with clinical and pathological features.RESULTS:There was a greater tendency towards HLA-G and IL-17 expression in specimens that showed CIN I, thus suggesting that these molecules have a contribution towards cervical progression.CONCLUSION:These findings suggest that HLA-G and IL-17 expression may be an early marker for assessing the progression of cervical lesions.

https://doi.org/10.1590/1516-3180.2013.7170009 46304 downloads

13.

Applications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screening
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Dunder, Ricardo Jose

; Luiz-Ferreira, Anderson

; Almeida, Ana Cristina Alves de

; de-Faria, Felipe Meira

; Takayama, Christiane

; Socca, Eduardo Augusto Rabelo

; Salvador, Marcos Jose

; Mello, Glaucia Coelho

; Santos, Catarina dos

; Oliva-Neto, Pedro de

; Souza-Brito, Alba Regina Monteiro

Memórias do Instituto Oswaldo Cruz

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may 2013, Volume 108 N. 3 Pages 263 - 271

Abstract: En | Text: En | PDF: En

The present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties.

https://doi.org/10.1590/S0074-02762013000300002 2531 downloads

14.

Validity of Qualis database as a predictor of evidence hierarchy and risk of bias in randomized controlled trials: a case study in dentistry
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Ferreira, Christiane Alves

; Loureiro, Carlos Alfredo Salles

; Saconato, Humberto

; Atallah, Alvaro

Clinics

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2011, Volume 66 N. 2 Pages 337 - 342

Abstract: En | Text: En | PDF: En

OBJECTIVE: To evaluate the validity of the Qualis database in identifying the levels of scientific evidence and the quality of randomized controlled trials indexed in the Lilacs database. METHODS: We selected 40 open-access journals and performed a page-by-page hand search, to identify published articles according to the type of study during a period of six years. Classification of studies was performed by independent reviewers assessed for their reliability. Randomized controlled trials were identified for separate evaluation of risk of bias using four dimensions: generation of allocation sequence, allocation concealment, blinding, and incomplete outcome data. The Qualis classification was considered to be the outcome variable. The statistical tests used included Kappa, Spearman's correlation, Kendall-tau and ordinal regressions. RESULTS: Studies with low levels of scientific evidence received similar Qualis classifications when compared to studies with high levels of evidence. In addition, randomized controlled trials with a high risk of bias for the generation of allocation sequences and allocation concealment were more likely to be published in journals with higher Qualis levels. DISCUSSION: The hierarchy level of the scientific evidence as classified by type of research design, as well as by the validity of studies according to the bias control level, was not correlated or associated with Qualis stratification. CONCLUSION: Qualis classifications for journals are not an approximate or indirect predictor of the validity of randomized controlled trials published in these journals and are therefore not a legitimate or appropriate indicator of the validity of randomized controlled trials.

https://doi.org/10.1590/S1807-59322011000200025 2404 downloads Cited 4 times in SciELO

15.

Custos para implantação e operação de serviço de saúde bucal na perspectiva do serviço e da sociedade
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Ferreira, Christiane Alves

; Loureiro, Carlos Alfredo

Cadernos de Saúde Pública

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sep 2008, Volume 24 N. 9 Pages 2071 - 2080

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste estudo foi avaliar custos de implantação e manutenção da assistência odontológica no setor público. Os custos foram atualizados/depreciados de acordo com a vida útil e considerados na perspectiva do serviço e da sociedade. Os resultados mostraram que, para o serviço, o custo total de implantação de uma unidade odontológica com sete consultórios foi de R$ 860.643,67 no primeiro ano e R$ 545.419,23 para manutenção, sendo clínica geral a especialidade mais cara. Para a sociedade, o custo total foi de R$ 990.065,06 (implantação) e R$ 668.369,55 (manutenção) e a especialidade mais cara foi prevenção. Custos de capital representaram um pequeno percentual dos custos de uma unidade odontológica, entretanto, deveriam ser considerados, pois podem modificar os resultados. Devido ao alto custo, intervenções preventivo-promocionais realizadas no ambiente clínico não deveriam ser recomendadas, devendo ser substituídas por ações populacionais amplas e de menor custo, uma vez que valores consideráveis necessitam ser desembolsados pela população de baixa renda para participar de programas públicos gratuitos.

The aim of this study was to assess the costs of setting up and maintaining dental care in the public sector. Costs were updated or depreciated according to the service's lifespan and were analyzed from the perspective of the service itself and society. According to the findings, for the service the total cost of setting up a dental care unit with seven rooms was BRL$860.643.67 in the first year, plus BRL$545,419.23 for maintenance, and clinical dental care was the most expensive specialty. For society, the total cost was BRL$990,065.06 (implementation) and BRL$668,369.55 (maintenance), and the most expensive specialty was prevention (US$1.00 = BRL$1.62). Capital costs represented a small percentage of total costs for a dental care unit, but they need to be considered, since they can modify the results. Due to the high costs, preventive and promotional interventions should not be performed in the clinical setting, but should be replaced by broader and less expansive population-based interventions, since considerable sums need to be spent by the low-income population to participate in free public programs.

3507 downloads Cited 6 times in SciELO

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