Considering the relevance of natural products to the development of new drugs, this study focuses on the species Sida rhombifolia (L.), Malvaceae, widely used as a traditional remedy in several countries. The species is used to treat several diseases such as fevers, skin diseases, stomach pain, diarrhea, gum infection, conjunctivitis, urinary infections and inflammation. Many researchers around the word have investigated its pharmacological potential, and many uses have been confirmed. In spite of that, the phytochemical composition of its extracts is still poorly investigated. This research aims to make advances on the understanding of the constituents of S. rhombifolia identifying its alkaloidal compounds using ultra-high performance liquid chromatography coupled to mass spectrometry (UPLC-QTOF-MS/MS). By analyzing its alkaloidal fraction, it was possible to identify: 11-cryptolepine carboxylic acid (1), cryptolepine (2), quindoline (3), 11 methoxyquidoline (4), quindolinone (5), cryptolepinone (6), and 11-quindoline methyl ester (7). The alkaloids 1 and 7 are being reported for the first time from Sida genus. Based on the antimicrobial potential of cryptolepinone-type alkaloids, we prepared by semi-synthesis two cryptolepinone derivatives: 10-methylcryptolepinone (8) and the unreported compound 10-ethylcryptolepinone (9). Both derivatives were tested against fungal and bacterial strains and 10-methylcryptolepinone (8) showed strong activity against Cryptococcus neoformans, Candida albicans, Candida tropicalis, Aspergillus fumigatus and Aspergillus flavus. drugs L., L L. , (L.) Malvaceae countries fevers pain diarrhea infection conjunctivitis inflammation confirmed that S ultrahigh ultra high UPLCQTOFMS/MS. UPLCQTOFMSMS UPLC QTOF MS/MS . MS (UPLC-QTOF-MS/MS) fraction identify 11cryptolepine 1, (1) 2, 2 (2) 3, 3 (3) 4, 4 (4) 5, 5 (5) 6, 6 (6) 11quindoline 7. (7) genus cryptolepinonetype type semisynthesis semi synthesis 10methylcryptolepinone methylcryptolepinone 10 8 (8 10ethylcryptolepinone ethylcryptolepinone 9. 9 (9) neoformans albicans tropicalis flavus (L. UPLCQTOFMS UPLCQTOFMS/MS MSMS (UPLC-QTOF-MS/MS (1 (2 (3 (4 (5 (6 (7 ( (9 (L

Abstract Introduction Fibromyalgia is a complex, generalized, and diffuse chronic musculoskeletal pain. Pharmacological approaches are widely used to relieve pain and increase quality of life. Low-Dose Naltrexone (LDN) was shown to increase the nociceptive threshold in patients with fibromyalgia. Transcranial Direct Current Stimulation (tDCS) is effective for pain management. Objective The purpose of this study was to evaluate the analgesic and neuromodulatory effects of a combination of LDN and tDCS in patients with fibromyalgia. Methods This was a randomized, double-blinded, parallel, placebo/sham-controlled trial (NCT04502251; RBR-7HK8N) in which 86 women with fibromyalgia were included, and written informed consent was obtained from them. The patients were allocated into four groups: LDN + tDCS (n = 21), LDN + tDCS Sham (n = 22), placebo + tDCS (n = 22), and placebo+tDCS Sham (n = 21). The LDN or placebo (p.o.) intervention lasted 26 days; in the last five sessions, tDCS was applied (sham or active, 20 min, 2 mA). The following categories were assessed: sociodemographic, Visual Analog Pain Scale (VAS), Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory (STAI), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI-II), Profile of Chronic Pain Scale (PCP:S), Pain Pressure Threshold (PPT), and Conditioned Pain Modulation (CPM). Blood samples were collected to analyze BDNF serum levels. Results At baseline, no significant difference was found regarding all measurements. VAS pain was significantly reduced in the LDN + tDCS (p = 0.010), LDN + tDCS Sham (p= 0.001), and placebo+tDCS Sham (p= 0.009) groups. In the PCP:S, the LDN+tDCS group showed reduced pain frequency and intensity (p= 0.001), effect of pain on activities (p= 0.014) and emotions (p= 0.008). Depressive symptoms reduced after all active interventions (p > 0.001). Conclusion Combined LDN+tDCS has possible benefits in reducing pain frequency and intensity; however, a placebo effect was observed in pain using VAS, and further studies should be performed to analyze the possible association. complex generalized life LowDose Low Dose (LDN (tDCS management randomized doubleblinded, doubleblinded double blinded, blinded double-blinded parallel placebo/shamcontrolled placeboshamcontrolled placebo/sham controlled sham NCT04502251 NCT (NCT04502251 RBR7HK8N RBRHKN RBR 7HK8N HK N RBR-7HK8N 8 included them groups n 21, 21 , 21) 22, 22 22) placebotDCS 21. . p.o. po p o (p.o. days sessions min mA. mA mA) assessed sociodemographic (VAS) PCS, PCS (PCS) StateTrait State Trait STAI, STAI (STAI) FIQ, FIQ (FIQ) BDIII, BDIII BDI II (BDI-II) PCPS, PCPS PCP S (PCP:S) PPT, PPT (PPT) CPM. CPM (CPM) levels baseline measurements 0.010, 0010 0.010 0 010 0.010) p= 0.001, 0001 0.001 001 0.001) 0.009 0009 009 S, PCP:S LDNtDCS 0.014 0014 014 0.008. 0008 0.008 008 0.008) 0.001. however association shamcontrolled placebosham NCT0450225 (NCT0450225 HKN p.o (p.o (VAS (PCS (STAI (FIQ (BDI-II (PCP:S (PPT (CPM 0.01 01 000 0.00 00 NCT045022 (NCT045022 0.0 NCT04502 (NCT04502 0. NCT0450 (NCT0450 NCT045 (NCT045 NCT04 (NCT04 NCT0 (NCT0 (NCT

RESUMO O artigo visou analisar o uso do aplicativo móvel, em especial, o WhatsApp, como ferramenta de gestão das ações de educação na saúde com ênfase na Educação Permanente em Saúde no estado do Rio de Janeiro. Estudo exploratório, de abordagem quantitativa, com uso de questionário on-line. Os participantes foram os gestores/responsáveis pelas ações de educação permanente. Os dados quantitativos foram tratados estatisticamente. Predominou o sexo feminino, a idade variou de 34 a 68 anos. O vínculo dominante foi o Estatutário Efetivo Municipal. Sobre o cargo/função ser exclusivamente relacionado com as atividades de educação permanente, mostrou não haver exclusividade das funções. O aplicativo é pouco utilizado nas atividades de planejamento, acompanhamento, monitoramento e avaliação. Foi apontado como uma ferramenta para receber/enviar mensagens, manter conversas em grupo e compartilhar documentos. As atividades mediatizadas pelo WhatsApp referem o uso para divulgação/inscrição em eventos, canal de comunicação e interação entre atores, planejamento/divulgação da participação em reuniões técnicas. Foram apontadas dificuldades na utilização do aplicativo relativas ao excesso de mensagens, que exigem disponibilidade de tempo para respondê-las. Há necessidade de novos estudos para o aprofundamento dos limites e possibilidades do uso do aplicativo na gestão dessas ações. Como limitações, aponta-se o estudo ter sido locorregional.

ABSTRACT The article aimed to analyze WhatsApp as a management tool for health education actions in the State of Rio de Janeiro. Exploratory study, with a quantitative approach, using an online questionnaire. The participants were the managers/responsible for Continuing Education actions. Quantitative data were treated statistically. Females predominated, age ranged between 34 and 68 years. The dominant link was the Municipal Effective Statutory. About the position/function being exclusively related to Continuing Education activities, it showed that there is no exclusivity of functions. The application is little used in planning, monitoring, follow-up, and evaluation activities. It was touted as a tool to receive/send messages, maintain group conversations, and share documents. The activities mediated by WhatsApp refer to the use for dissemination/ registration in events, communication, and interaction channel between actors, planning/dissemination of participation in technical meetings. Difficulties in using the application related to the excess of messages were pointed out, which require availability of time to respond to them. There is a need for further studies to deepen the limits and possibilities of using the application in the management of these actions. As limitations, it is pointed out that the study was locoregional.

RESUMO O artigo visou analisar o uso do aplicativo móvel, em especial, o WhatsApp, como ferramenta de gestão das ações de educação na saúde com ênfase na Educação Permanente em Saúde no estado do Rio de Janeiro. Estudo exploratório, de abordagem quantitativa, com uso de questionário on-line. Os participantes foram os gestores/responsáveis pelas ações de educação permanente. Os dados quantitativos foram tratados estatisticamente. Predominou o sexo feminino, a idade variou de 34 a 68 anos. O vínculo dominante foi o Estatutário Efetivo Municipal. Sobre o cargo/função ser exclusivamente relacionado com as atividades de educação permanente, mostrou não haver exclusividade das funções. O aplicativo é pouco utilizado nas atividades de planejamento, acompanhamento, monitoramento e avaliação. Foi apontado como uma ferramenta para receber/enviar mensagens, manter conversas em grupo e compartilhar documentos. As atividades mediatizadas pelo WhatsApp referem o uso para divulgação/inscrição em eventos, canal de comunicação e interação entre atores, planejamento/divulgação da participação em reuniões técnicas. Foram apontadas dificuldades na utilização do aplicativo relativas ao excesso de mensagens, que exigem disponibilidade de tempo para respondê-las. Há necessidade de novos estudos para o aprofundamento dos limites e possibilidades do uso do aplicativo na gestão dessas ações. Como limitações, aponta-se o estudo ter sido locorregional.

ABSTRACT The article aimed to analyze WhatsApp as a management tool for health education actions in the State of Rio de Janeiro. Exploratory study, with a quantitative approach, using an online questionnaire. The participants were the managers/responsible for Continuing Education actions. Quantitative data were treated statistically. Females predominated, age ranged between 34 and 68 years. The dominant link was the Municipal Effective Statutory. About the position/function being exclusively related to Continuing Education activities, it showed that there is no exclusivity of functions. The application is little used in planning, monitoring, follow-up, and evaluation activities. It was touted as a tool to receive/send messages, maintain group conversations, and share documents. The activities mediated by WhatsApp refer to the use for dissemination/ registration in events, communication, and interaction channel between actors, planning/dissemination of participation in technical meetings. Difficulties in using the application related to the excess of messages were pointed out, which require availability of time to respond to them. There is a need for further studies to deepen the limits and possibilities of using the application in the management of these actions. As limitations, it is pointed out that the study was locoregional.

Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

Resumo Objetivo Analisar os uniformes usados na cerimônia de formatura de enfermeiras e seus significados para a identidade profissional. Método Estudou-se uma escola de enfermagem de Minas Gerais, no período de 1947 até 1964. Pesquisa qualitativa, histórico-social, mediante a qual foram analisados documentos escritos, fotográficos e orais, considerando as bases conceituais de identidade profissional, do sociólogo Claude Dubar, e de vestuário e seus significados simbólicos, de Roland Barthes. Resultados O uniforme das enfermeiras, usado na formatura, possuía signos de identidade institucional e profissional. Foi constituído pelo clássico vestido branco, com touca e outros acessórios. Conclusões e implicações para a prática O uniforme de formatura de enfermeiras correspondeu aos avanços da moda e da cientificidade, configurando-se uma marca na construção do papel e consolidação da identidade profissional, contribuindo para a identificação de uma categoria profissional em formação.

Abstract Objective to analyze the uniforms used in the graduation ceremony of nurses and their meanings for professional identity. Method A nursing school in Minas Gerais was studied from the period of 1947 to 1964. Qualitative, social-historical research, through which written, photographic and oral documents were analyzed, considering the conceptual bases of professional identity, by the sociologist Claude Dubar, and of clothing and its symbolic meanings, by Roland Barthes. Results The nurses' uniform used at graduation had institutional and professional identity signs. It consisted of the classic white dress, with a cap and other accessories. Conclusions and implications for practice The nurse's graduation uniform corresponded to the advances in fashion and scientificity, becoming a mark in the construction of the role and a consolidation of professional identity, contributing to the identification of a professional category in training.

Resumen Objetivo Analizar los uniformes utilizados en la ceremonia de graduación de enfermeras y sus significados para la identidad profesional. Método Se estudió una escuela de enfermería de Minas Gerais, relativo al periodo de 1947 a 1964. Investigación cualitativa, histórico-social, en la que se analizaron documentos escritos, fotográficos y orales, considerando las bases conceptuales de la identidad profesional, del sociólogo Claude Dubar, y de vestuario y sus significados simbólicos, de Roland Barthes. Resultados El uniforme de las enfermeras, utilizado en la graduación, presentaba señales de identidad institucional y profesional. Consistía en el clásico vestido blanco, con gorra y otros complementos. Conclusiones e implicaciones para la práctica El uniforme de graduación de enfermeras correspondió a los avances de moda y cientificidad, convirtiéndose en una marca en la construcción y consolidación de la identidad profesional, contribuyendo para la identificación de una categoría profesional en formación.

ABSTRACT Background: Rapid molecular methods such as the line probe assay (LPA) and Xpert® MTB/RIF assay (Xpert) have been recommended by the World Health Organization for drug-resistant tuberculosis (DR-TB) diagnosis. We conducted an interventional trial in DR-TB reference centers in Brazil to evaluate the impact of the use of LPA and Xpert. Methods: Patients with DR-TB were eligible if their drug susceptibility testing results were available to the treating physician at the time of consultation. The standard reference MGITTM 960 was compared with Xpert (arm 1) and LPA (arm 2). Effectiveness was considered as the start of the appropriate TB regimen that matched drug susceptibility testing (DST) and the proportions of culture conversion and favorable treatment outcomes after 6 months. Results: A higher rate of empirical treatment was observed with MGIT alone than with the Xpert assay (97.0% vs. 45.0%) and LPA (98.2% vs. 67.5%). Patients started appropriate TB treatment more quickly than those in the MGIT group (median 15.0 vs. 40.5 days; p<0.01) in arm 1. Compared to the MGIT group, culture conversion after 6 months was higher for Xpert in arm 1 (90.9% vs. 79.3%, p=0.39) and LPA in arm 2 (80.0% vs. 83.0%, p=0.81). Conclusions: In the Xpert arm, there was a significant reduction in days to the start of appropriate anti-TB treatment and a trend towards greater culture conversion in the sixth month.

Abstract Sjogren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

ABSTRACT Objective: Percutaneous ethanol injection (PEI) is an alternative to surgery for the treatment of thyroid nodules (TNs). However, size reductions of treated (TTNs) and untreated TN (UTNs) have not been compared. Volumetric reductions in TTNs with PEI were evaluated by comparing TTNs and UTNs in the same patient, and independent variables predicting good post-PEI outcomes were analyzed. Materials and methods: Overall, 282 patients with multinodular goiters were selected. Two nodules located in different lobes were compared for common disease behaviors. Overall, 150 nodules were selected from 75 patients (6 M: 69 F) with a mean age of 50.1 ± 17.4 years. This prospective nonrandomized intervention study prioritized treating TNs of greater volume or single hyperfunctioning TNs. A single observer experienced in PEI and an ultrasound specialist performed the interventions. Results and discussion: TTNs (mean volume: 14.8 ± 16.2 mL) were reduced by 72.6 ± 27.3% of their initial volume, while UTNs increased by a mean of 365.7 ± 1.403.8% (p < 0.00001). The patients underwent a mean of 4.0 ± 3.1 outpatient PEI sessions without relevant complications. Logistic regression analysis showed that the magnitude of the PEI induced reduction was associated with the number of treatment sessions (p = 0.03, CI [1.1-38.2]) and not with ultrasonographic characteristics of the nodules. Each PEI session increased the rate of TN reduction by a factor of 6.7. Conclusions: PEI is a well-tolerated outpatient procedure that effectively reduces the volume of TNs and is noticeably superior to conservative treatment for all ultrasonographic classifications.

Resumo Objetivo analisar as relações entre a esperança e o bem-estar psicológico de estudantes de enfermagem portugueses durante a crise pandêmica pela COVID-19. Método estudo descritivo-correlacional, com recurso a questionário online para coleta de dados. Participaram 705 estudantes de enfermagem com idade média de 21,74 anos (DP=4,44). Os instrumentos de coleta de dados utilizados foram a Escala de Esperança de Herth (HHI-PT) e a Escala de Medida de Manifestação de Bem-Estar Psicológico (EMMBEP). Foi utilizada a estatística descritiva e inferencial. Resultados na HHI-PT, o domínio afectivo-comportamental obteve a pontuação média mais alta, 3,30 (DP=0,45); no EMMBEP, foi o domínio sociabilidade, 3,64 (DP=0,77). Havia correlações moderadas a fortes (0,383 <r <0,917) entre o global e todos os domínios da esperança e bem-estar psicológico (≤0.001). Conclusão e implicações para a prática a esperança e o bem-estar psicológico dos estudantes de enfermagem durante a pandemia são variáveis correlacionados positivamente entre si. As medidas de promoção da saúde mental, a implementar pelas instituições de ensino, devem ter em consideração a associação entre essas duas variáveis.

Abstract Aim to analyze the relationship between hope and the psychological well-being of Portuguese nursing students during the COVID-19 pandemic crisis. Method this is a descriptive-correlational study using an online questionnaire for data collection. 705 nursing students participated, with a mean age of 21.74 years (SD=4.44). The data collection instruments used were the Herth Hope Index (HHI-PT) and the Well-Being Manifestations Measure Scale (WBMMS). Descriptive and inferential statistics were used. Results in the HHI-PT, the affective-behavioral domain had the highest mean score (3.30; SD=0.45), while in the WBMMS, it was the sociability domain, 3.64 (SD=0.77). There were moderate to strong correlations (0.383 <r <0.917) between the global and all domains of hope and psychological well-being (≤0.001). Conclusion and implications for practice nursing students’ hope and psychological well-being during the pandemic are variables that are positively correlated with each other. Strategies to promote mental health, to be implemented by educational institutions, must consider the association between these two variables.

Resumen Objetivo analizar la relación entre la esperanza y el bienestar psicológico de los estudiantes portugueses de enfermería durante la crisis pandémica por COVID-19. Método estudio descriptivo-correlacional mediante cuestionario online para la recogida de datos. Participaron 705 estudiantes de enfermería, con una edad promedio de 21,74 años (DE=4,44). Los instrumentos de recolección de datos utilizados fueron la Escala de Esperanza de Herth (HHI-PT) y la Escala de Medida de Manifestación de Bienestar Psicológico (EMMBEP). Se utilizó estadística descriptiva e inferencial. Resultados en HHI-PT, fue el dominio afectivo-conductual el que obtuvo la puntuación promedio más alta, 3.30 (DE=0.45), en EMMBEP, fue el dominio de sociabilidad, 3.64 (DE=0.77). Hubo correlaciones de moderadas a fuertes (0.383 <r <0.917) entre el dominio global y todos los dominios de la esperanza y el bienestar psicológico (≤0.001). Conclusión e implicaciones para la práctica la esperanza y el bienestar psicológico de los estudiantes de enfermería durante la pandemia son variables que se correlacionan positivamente entre sí. Las medidas de promoción de la salud mental, a ser implementadas por las instituciones educativas, deben tener en cuenta la asociación entre estas dos variables.

Abstract Sjogren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and need extra care regarding their sexual activity, reproductive health and during pregnancy, conditions that are not properly conducted in the clinical practice. To cover this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of symptoms, diagnosis, monitoring, prognosis, and treatment of these manifestations. A Focus Group meeting was held and included experts in the field and methodologists, based on a previously developed script, with themes related to the objective of the study. The most important topics were summarized and 11 recommendations were provided.

Abstract This report describes a case of multisystem inflammatory syndrome in a child that evolved with a pattern of toxic shock syndrome with coronary artery ectasia and neurological involvement, documented by magnetic resonance imaging, with changes in the corpus callosum and myopathy in the pelvic girdle and paravertebral musculature.

Resumo Neste artigo nós apresentamos uma visão geral dos resumos, programação científica e social, viagens de campo e informações acerca do número de inscritos, países participantes, patrocínios e temas tratados durante a Sexta Conferência Internacional sobre Biologia Comparada de Monocotiledôneas, realizada em Natal, Brasil, de 7 a 12 de outubro de 2018. Alguns comentários recebidos pelos organizadores e sugestões para os organizadores do próximo Monocots, na Costa Rica, também são fornecidos. Este artigo complementa os dados publicados no livro de resumos, disponível no Repositório Digital da UFRN.

Abstract In this paper we present an overview of the abstracts, scientific and social programs, field trips, and achievements in terms of participant number, represented countries, sponsorships, and themes treated during the Sixth International Conference on the Comparative Biology of Monocotyledons that took place in Natal, Brazil, October 7th -12th 2018. Some comments received by the organizers and a few suggestions for organizers of the next meeting, in Costa Rica, are also provided. The conference’s complete abstract book was published and provide additional information.

Contexto: El final del siglo XIX y el comienzo del siglo XX es un período de profundas transformaciones en las instituciones de asistencia y en sus profesionales. Objetivo: Conocer este período de la historia de la enfermería en Portugal. Analizar los anuarios de la Universidad de Coímbra, considerándolos como una fuente primaria. Metodología: Análisis descriptivo histórico de 73 anuarios, con estudio de las fuentes y construcción de síntesis descriptivas e interpretativas. Resultados: Comprobamos la concentración de material de los años comprendidos entre 1896 y 1927. El análisis resumió 4 temas: 1) nombres y funciones de los enfermeros; 2) los enfermeros en el decreto de reforma de los Hospitales Universitarios de Coímbra en 1911, el equipo y los sueldos en 1915-16; 3) los enfermeros ecuestres y militares en 1915-16 y 1917-18; 4) la escuela de enfermería de 1919-20 a 1926-27 y los profesores universitarios. Conclusión: Encontramos 104 nombres de enfermeros, con funciones definidas, considerados personal auxiliar y no personal clínico. El enfermero jefe aparece destacado. Aparece la escuela de enfermería de los hospitales universitarios, con la identificación de los profesores universitarios a cargo.

Contexto: O final do século XIX e o início do século XX é um período de profundas transformações nas instituições de assistência e nos seus profissionais. Objetivo: Conhecer este período da história da enfermagem em Portugal. Analisar os anuários da Universidade de Coimbra, considerando-os como fonte primária. Metodologia: Análise descritiva histórica de 73 anuários, com levantamento de fontes e construção de síntese descritiva e interpretativa. Resultados: Verificámos a concentração de material nos anos 1896 a 1927. A análise, sintetizou 4 tópicos: 1) nomes e funções dos enfermeiros; 2) os enfermeiros, no decreto de reforma dos Hospitais da Universidade de Coimbra, em 1911, o quadro e os vencimentos em 1915-16; 3) enfermeiros hípicos e militares em 1915-16 e 1917-18; 4) a escola de enfermagem de 1919-20 a 1926-27 e os professores universitários. Conclusão: Encontrámos 104 nomes de enfermeiros, com funções definidas, considerados pessoal auxiliar e não pessoal clínico. O enfermeiro chefe surge com destaque. Aparece a escola de enfermagem dos hospitais da universidade, com a identificação dos professores universitários regentes.

Background: The end of the 19th century and the beginning of the 20th century combine a period of profound transformations in care institutions and their professionals. Objective: To know this period of nursing history in Portugal, analyze the yearbooks of the University of Coimbra, considering them as the primary source. Methodology: Descriptive historical analysis of 73 yearbooks, with a survey of sources and construction of descriptive and interpretative synthesis. Results: The available material was centered on the years 1896 to 1927. The analysis synthesized 4 topics: 1) names and functions of nurses; 2) nurses, in the decree of the reform of the Hospitals of the University of Coimbra, in 1911, the staff and salaries in 1915-16; 3) equine veterinary nurses and military nurses in 1915-16 and 1917-18; 4) the nursing school from 1919-20 to 1926-27 and university professors. Conclusion: We found 104 names with defined functions, considered as auxiliary staff and non-clinical personnel. The head nurse comes out prominently. The nursing school of the university hospitals appears, with the identification of the university head teachers.