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Microbial keratitis in Sao Paulo, Brazil: a 10-year review of laboratory results, epidemiological features, and risk factors Paulo Brazil 10year year 10 results features 1
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Kase, Camila

; Boppré, Yasmin Tournier

; Rocchetti, Talita Trevizani

; Yu, Maria Cecília Zorat

; Fernandes, Arthur Gustavo

; Hofling-Lima, Ana Luisa

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 6 elocation e2022-00660

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Estudar os dados epidemiológicos, resultados laboratoriais e fatores de risco associados às ceratites infecciosas. Métodos: Estudo retrospectivo das amostras de cultura de córnea em pacientes com ceratites infecciosas entre Janeiro/2010 a Dezembro/2019. Os resultados foram analisados de acordo com o diagnóstico etiológico de infecção bacteriana, fúngica ou parasitária e correlacionado com os fatores de risco relacionados. Resultados: Quatro mil, oitocentas e dez amostras corneanas de 4047 pacientes (média de idade de 47,79 ± 20,68 anos; homens em sua maioria (53,7%) foram incluídas. A prevalência de infecções por bactéria, fungo e Acanthamoeba foram de 69.80%, 7,31%, and 3,51%, respectivamente. A maioria das bactérias mais frequentemente isoladas foram Staphylococcus coagulase-negativo (CoNS) (45,14%), S. aureus (10,02%), Pseudomonas spp. (8,80%), e Corynebacterium spp. (6,21%). Dentre CoNS, o principal agente foi S. epidermidis (n = 665). Nas ceratites fúngicas, Fusarium spp. (35,42%) e Candida parapsilosis (16,07%) foram os agentes mais comuns entre os filamentosos e leveduriformes, respectivamente. O uso de lentes de contato foi associado à cultura positiva para Acanthamoeba spp. (OR = 19,04; p < 0,001) e Pseudomonas spp (OR = 3,20; p < 0,001). Trauma ocular prévio foi associado a culturas positivas para fungo (OR = 1,80; p = 0,007), e idade avançada foi associada a culturas positivas para bactéria (OR = 1,76; p = 0,001). Conclusões: Nossos achados demonstraram uma maior positividade para bactérias em amostras de cultura corneana. Dentre estas, CoNS foi mais frequentemente identificado, sendo S. epidermidis o principal agente. Nas ceratites fúngicas, Fusarium spp. Foi o mais comumente isolado. O risco de positividade para Acanthamoeba spp. e Pseudomonas spp. foi maior em usuários de lentes de contato. Trauma ocular aumentou o risco de cultura positiva para fungo, ao passo que idade mais avançada aumentou o risco de infecção bacteriana. Objetivo epidemiológicos Métodos Janeiro2010 Janeiro 2010 Janeiro/201 Dezembro2019 Dezembro 2019 Dezembro/2019 bacteriana relacionados Resultados mil 404 média 4779 47 79 47,7 2068 20 68 20,6 anos 53,7% 537 53 7 (53,7% incluídas 6980 69 80 69.80% 731 31 7,31% 351 3 51 3,51% respectivamente coagulasenegativo coagulase negativo (CoNS 45,14%, 4514 45,14% , 45 14 (45,14%) S 10,02%, 1002 10,02% 10 02 (10,02%) 8,80%, 880 8,80% 8 (8,80%) 6,21%. 621 6,21% . 6 21 (6,21%) n 665. 665 665) fúngicas 35,42% 3542 35 42 (35,42% 16,07% 1607 16 07 (16,07% leveduriformes OR 19,04 1904 19 04 0,001 0001 0 001 3,20 320 0,001. 1,80 180 1 0,007, 0007 0,007 007 0,007) 1,76 176 76 Conclusões corneana estas identificado isolado Janeiro201 201 Janeiro/20 Dezembro201 Dezembro/201 40 477 4 47, 206 2 20, 53,7 5 (53,7 698 69.80 73 7,31 3,51 451 45,14 (45,14% 100 10,02 (10,02% 88 8,80 (8,80% 62 6,21 (6,21% 66 35,42 354 (35,42 16,07 160 (16,07 19,0 190 0,00 000 00 3,2 32 1,8 18 1,7 17 Janeiro20 Janeiro/2 Dezembro20 Dezembro/20 53, (53, 69.8 7,3 3,5 45,1 (45,14 10,0 (10,02 8,8 (8,80 6,2 (6,21 35,4 (35,4 16,0 (16,0 19, 0,0 3, 1, Janeiro2 Janeiro/ Dezembro2 Dezembro/2 (53 69. 7, 45, (45,1 10, (10,0 8, (8,8 6, (6,2 35, (35, 16, (16, 0, Dezembro/ (5 (45, (10, (8, (6, (35 (16 ( (45 (10 (8 (6 (3 (1 (4

ABSTRACT Purpose: To study epidemiological data, laboratory results, and risk factors associated with microbial keratitis. Methods: We conducted a retrospective study of corneal sample cultures from patients with microbial keratitis from January 2010 to December 2019. Results were analyzed according to the etiological diagnosis of bacterial, mycotic, or parasitic infection and were associated with related risk factors. Results: We analyzed 4810 corneal samples from 4047 patients (mean age 47.79 ± 20.68 years; male 53.27%). The prevalence of bacterial, fungal, and Acanthamoeba infections were 69.80%, 7.31%, and 3.51%, respectively. The most frequently isolated bacteria were coagulase-negative Staphylococcus (CoNS) (45.14%), S. aureus (10.02%), Pseudomonas spp. (8.80%), and Corynebacterium spp. (6.21%). Among CoNS, the main agent was S. epidermidis (n=665). For mycotic keratitis, Fusarium spp. (35.42%) and Candida parapsilosis (16.07%) were the most common agents among filamentous and yeasts isolates, respectively. Contact lens use was associated with a positive culture for Acanthamoeba spp. (OR = 19.04; p < 0.001) and Pseudomonas spp. (OR = 3.20; p < 0.001). Previous ocular trauma was associated with positive fungal cultures (OR = 1.80; p = 0.007), while older age was associated with positive bacterial culture (OR = 1.76; p = 0.001). Conclusions: Our findings demonstrated a higher positivity of corneal sample cultures for bacteria. Among those, CoNS was the most frequently identified, with S. epidermidis as the main agent. In fungal keratitis, Fusarium spp. was the most commonly isolated. Contact lens wearers had higher risks of positive cultures for Acanthamoeba spp. and Pseudomonas spp. Ocular trauma increased the risk of fungal infection, while older age increased the risk of bacterial infection. Purpose data results Methods 201 2019 481 404 mean 4779 47 79 47.7 2068 20 68 20.6 years 53.27%. 5327 53.27% . 53 27 53.27%) 6980 69 80 69.80% 731 7 31 7.31% 351 3 51 3.51% respectively coagulasenegative coagulase negative (CoNS 45.14%, 4514 45.14% , 45 14 (45.14%) S 10.02%, 1002 10.02% 10 02 (10.02%) spp 8.80%, 880 8.80% 8 (8.80%) 6.21%. 621 6.21% 6 21 (6.21%) n=665. n665 n n=665 665 (n=665) 35.42% 3542 35 42 (35.42% 16.07% 1607 16 07 (16.07% isolates OR 19.04 1904 19 04 0.001 0001 0 001 3.20 320 0.001. 1.80 180 1 0.007, 0007 0.007 007 0.007) 1.76 176 76 Conclusions those identified 48 40 477 4 47. 206 2 20. 532 53.27 5 698 69.80 73 7.31 3.51 451 45.14 (45.14% 100 10.02 (10.02% 88 8.80 (8.80% 62 6.21 (6.21% n66 n=66 66 (n=665 35.42 354 (35.42 16.07 160 (16.07 19.0 190 0.00 000 00 3.2 32 1.8 18 1.7 17 53.2 69.8 7.3 3.5 45.1 (45.14 10.0 (10.02 8.8 (8.80 6.2 (6.21 n6 n=6 (n=66 35.4 (35.4 16.0 (16.0 19. 0.0 3. 1. 53. 69. 7. 45. (45.1 10. (10.0 8. (8.8 6. (6.2 n= (n=6 35. (35. 16. (16. 0. (45. (10. (8. (6. (n= (35 (16 (45 (10 (8 (6 (n (3 (1 (4 (

https://doi.org/10.5935/0004-2749.2022-0060

Impression cytology of ocular surface in xeroderma pigmentosum
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Marcos, Allexya Affonso Antunes

; Freitas, Denise

; Barros, Jeison de Nadai

; Fernandes, Arthur Gustavo

; Lowen, Márcia

; Rigueiro, Moacyr

; Morales, Melina Correia

; Belfort Neto, Rubens

; Singh, Arun D.

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 4 elocation e2023-0026

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To describe cellular alterations detected by impression cytology of the ocular surface in patients with xeroderma pigmentosum. The secondary objective was to assess the reliability of impression cytology in diagnosing ocular surface squamous neoplasia. Methods: Patients with xeroderma pigmentosum underwent a single-day complete ophthalmological examination and impression cytology for ocular surface evaluation using 13 mm diameter mixed cellulose esters membrane filters and combined staining with Periodic Acid Schiff, Hematoxylin and Eosin, and Papanicolaou stains followed by microscopic analysis. The cytological findings were correlated with the clinical diagnosis. The impression cytology findings at baseline and one-year follow-up were correlated with the clinical course (no tumor, treated tumor, residual tumor recurrent tumor, new tumor). Results: Of the 42 patients examined, impression cytology was performed in 62 eyes of 34 participants (65% females). The mean age of patients was 29.6 ± 17 years (range 7-62). Fifteen eyes had a clinical diagnosis of ocular surface squamous neoplasia. Impression cytology showed goblet cells (47, 75%), inflammatory cells (12, 19%), keratinization (5, 8%), and squamous metaplasia (30, 48%). Impression cytology was positive for atypical cells in 18 patients (12 with and 6 without ocular surface squamous neoplasia). The sensitivity, specificity, positive predictive value, and negative predictive value of impression cytology (at baseline) for diagnosis of ocular surface squamous neoplasia were 80%, 87%, 67%, and 93%, respectively, using clinical diagnosis of ocular surface squamous neoplasia as the reference standard. Conclusion: Impression cytology has a moderate positive predictive value for the diagnosis of ocular surface squamous neoplasia in patients with xeroderma pigmentosum. However, the lack of detection of atypical cells on impression cytology has a high negative predictive value for ocular surface squamous neoplasia. Integration of impression cytology in the long-term management of high-risk patients, such as patients with xeroderma pigmentosum, can avoid unnecessary diagnostic biopsies. Purpose Methods singleday single day 1 Schiff Eosin analysis oneyear one year followup follow up no tumor. . tumor) Results 4 examined 3 65% 65 (65 females. females females) 296 29 29. range 762. 762 7 7-62) 47, 47 (47 75%, 75 75% , 75%) 12, 12 19%, 19 19% 19%) 5, 5 (5 8%, 8 8% 8%) 30, 30 (30 48%. 48 48% 48%) (1 neoplasia) sensitivity specificity 80 80% 87 87% 67 67% 93 93% respectively standard Conclusion However longterm long term highrisk risk biopsies (6 2 76 7-62 (4 ( (3 9 7-6 7-

https://doi.org/10.5935/0004-2749.2023-0026

Evaluation of Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum
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Marcos, Allexya Affonso Antunes

; Freitas, Denise

; Hazarbassanov, Rossen Mihaylov

; Fernandes, Arthur Gustavo

; Castro, Ligia Pereira

; Melo, Danilo Batista Vieira de

; Menck, Carlos F. Martins

; Morales, Melina Correia

; Gomes, José Álvaro Pereira

; Belfort Neto, Rubens

; Singh, Arun D.

Arquivos Brasileiros de Oftalmologia

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2024, Volume 87 N. 2 elocation e2022-0319

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To assess Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum and correlate with ocular surface changes. Methods: This cross-sectional study evaluated patients with xeroderma pigmentosum. All patients underwent a comprehensive and standardized interview. The best-corrected visual acuity of each eye was determined. Detailed ophthalmic examination was conducted, including biomicroscopy examination of the ocular surface, Schirmer test type I, and meibography, and fundus examination was also performed when possible. Meibomian gland dysfunction was assessed by non-contact meibography using Oculus Keratograph® 5M (OCULUS Inc., Arlington, WA, USA). Saliva samples were collected using the Oragene DNA Self-collection kit (DNA Genotek Inc., Ottawa, Canada), and DNA was extracted as recommended by the manufacturer. Factors associated with abnormal meiboscores were assessed using generalized estimating equation models. Results: A total of 42 participants were enrolled, and 27 patients underwent meibography. The meiboscore was abnormal in the upper eyelid in 8 (29.6%) patients and in the lower eyelid in 17 (62.9%). The likelihood of having abnormal meiboscores in the lower eyelid was 16.3 times greater than that in the upper eyelid. In the final multivariate model, age (p=0.001), mutation profile (p=0.006), and presence of ocular surface malignant tumor (OSMT) (p=0.014) remained significant for abnormal meiboscores. For a 1-year increase in age, the likelihood of abnormal meiboscores increased by 12%. Eyes with OSMT were 58.8 times more likely to have abnormal meiboscores than eyes without ocular surface malignant tumor. Conclusion: In the final model, age, xeroderma pigmentosum profile, previous cancer, and clinical alterations on the eyelid correlated with a meiboscore of ≥2. Meibomian gland dysfunction was common in patients with xeroderma pigmentosum, mainly in the lower eyelid. The severity of Meibomian gland dysfunction increases with age and is associated with severe eyelid changes. Purpose changes Methods crosssectional cross sectional interview bestcorrected best corrected determined conducted I possible noncontact non contact Keratograph M OCULUS Inc Inc. Arlington WA USA. USA . USA) Selfcollection Self collection Ottawa Canada, Canada , Canada) manufacturer models Results 4 enrolled 2 29.6% 296 29 6 (29.6% 1 62.9%. 629 62.9% 62 9 (62.9%) 163 16 3 16. model p=0.001, p0001 p p=0.001 0 001 (p=0.001) p=0.006, p0006 p=0.006 006 (p=0.006) (OSMT p=0.014 p0014 014 (p=0.014 1year year 12 12% 588 58 58. Conclusion cancer ≥2 29.6 (29.6 62.9 (62.9% p000 p=0.00 00 (p=0.001 (p=0.006 p=0.01 p001 01 (p=0.01 5 ≥ 29. (29. 62. (62.9 p00 p=0.0 (p=0.00 (p=0.0 (29 (62. p0 p=0. (p=0. (2 (62 p=0 (p=0 ( (6 p= (p= (p

https://doi.org/10.5935/0004-2749.2022-0319

Vision impairment and blindness in individuals aged 60 years and older in Latin America and the Caribbean
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Morsch, Patricia

; Hommes, Carolina

; Fernandes, Arthur Gustavo

; Limburg, Hans

; Furtado, João Marcello

; Vega, Enrique

Revista Panamericana de Salud Pública

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2024, Volume 48 elocation e101

Abstract: Es Pt En | Text: Es Pt En | PDF: Es | PDF: Pt | PDF: En

RESUMEN Objetivo. Determinar la prevalencia y las causas de la pérdida de visión y calcular la cobertura efectiva de la cirugía de las cataratas en personas mayores de 60 años en América Latina y el Caribe en el 2020. Métodos. Se utilizaron como fuentes la base de datos del Atlas de la Visión de la Agencia Internacional para la Prevención de la Ceguera y la de Rapid Assessment of Avoidable Blindness [evaluación rápida de la ceguera evitable]. Los datos recopilados se utilizaron para estimar la prevalencia y las causas de la pérdida de visión en personas mayores de 60 años y para determinar la cobertura efectiva de la cirugía de las cataratas. Resultados. La prevalencia general de la discapacidad visual moderada a grave y de la ceguera en América Latina y el Caribe fue del 14,14% y el 2,94%, respectivamente. La subregión de América Latina tropical presentó la mayor prevalencia de ceguera (3,89%), mientras que la de América Latina austral registró la menor (0,96%). Tanto en el caso de la discapacidad visual moderada a grave como en el de la ceguera, la causa principal de pérdida de visión fueron las cataratas. Hubo grandes diferencias en la tasa de cobertura efectiva de la cirugía de las cataratas, con valores que iban del 4,0% en Guatemala al 75,2% en Suriname. Conclusiones. La prevalencia de la pérdida de visión en personas mayores de 60 años en América Latina y el Caribe fue superior a la indicada por las estimaciones anteriores en grupos de menor edad. Las cataratas fueron la principal causa de ceguera, y la cobertura efectiva de la cirugía de las cataratas indica la necesidad de mejorar los resultados de estas intervenciones. Las autoridades de salud pública que pretendan abordar la pérdida de visión en este grupo deben adoptar medidas específicas que se asocien a una mejora del acceso, la integración de las exploraciones oftalmológicas en los programas de atención primaria, la ampliación del uso de la telemedicina y la mejora de la calidad de los datos.

RESUMO Objetivo. Determinar a prevalência e as causas da perda de visão e calcular a cobertura efetiva da cirurgia de catarata em adultos com 60 anos ou mais na América Latina e no Caribe em 2020. Métodos. Foram usadas as bases de dados do Atlas da Visão da Agência Internacional para a Prevenção da Cegueira e da Avaliação Rápida da Cegueira Evitável (RAAB, na sigla em inglês) como fonte de dados. Os dados coletados foram usados para estimar a prevalência e as causas da perda de visão em pessoas com 60 anos ou mais e para determinar a cobertura efetiva da cirurgia de catarata. Resultados. A prevalência global de deficiência visual moderada a grave e cegueira na América Latina e no Caribe foi de 14,14% e 2,94%, respectivamente. A América Latina Tropical foi a sub-região com a maior prevalência de cegueira (3,89%), ao passo que a América Latina Meridional teve a menor prevalência (0,96%). Tanto na deficiência visual moderada a grave quanto na cegueira, a catarata foi a principal causa da perda de visão. As taxas de cobertura efetiva da cirurgia de catarata variaram muito, desde 4,0% na Guatemala até 75,2% no Suriname. Conclusões. A prevalência da perda de visão em adultos com 60 anos ou mais na América Latina e no Caribe foi maior do que as estimativas anteriores em grupos de indivíduos mais jovens. A catarata foi a principal causa de cegueira, e a cobertura efetiva da cirurgia de catarata indica que os desfechos dessa cirurgia precisam ser melhorados. Medidas específicas associadas à melhoria do acesso, à integração da avaliação oftalmológica aos programas de atenção primária, à expansão do uso da telemedicina e à melhoria da qualidade dos dados devem ser adotadas pelas autoridades de saúde pública com o objetivo de enfrentar a perda de visão nesse grupo.

ABSTRACT Objective. To determine the prevalence and causes of vision loss and calculate the effective cataract surgery coverage (eCSC) in adults aged 60 years and older in Latin America and the Caribbean in 2020. Methods. The International Agency for the Prevention of Blindness Vision Atlas and the Rapid Assessment of Avoidable Blindness databases were used as data source. The collected data were used to estimate the prevalence and causes of vision loss in people aged 60 years and older, and to determine the eCSC. Results. The overall prevalence of moderate to severe vision impairment (MSVI) and blindness in Latin America and the Caribbean were 14.14% and 2.94%, respectively. Tropical Latin America was the subregion with the highest prevalence of blindness (3.89%) while Southern Latin America had the lowest (0.96%). For both MSVI and blindness, cataract was the main cause of vision loss. The eCSC rates showed great variation, ranging from 4.0% in Guatemala to 75.2% in Suriname. Conclusions. The prevalence of vision loss in adults aged 60 years and older in Latin America and the Caribbean was higher than previous estimates on younger groups. Cataract was the main cause of blindness, and the eCSC indicates that the outcomes from cataract surgery should be improved. Specific actions associated with improving access, integrating eye assessment with primary care programs, expanding the use of telemedicine, and improving data quality should be taken by public health authorities aiming to address vision loss in this group.

https://doi.org/10.26633/rpsp.2024.101

From a nutraceutical and anti-nutritional perspective, can a grain soybean cultivar be used as vegetable soybean? antinutritional anti nutritional perspective
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Ribera, Laura Matos

; Filho, Arthur Bernardes Cecílio

; Fernandes, Gustavo do Carmo

; Aires, Eduardo Santana

; Silva, Maiele Leandro da

; Bonfim, Filipe Pereira Giardini

Ciência Rural

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2024, Volume 54 N. 12 elocation e20230518

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A soja-hortaliça apresenta alto valor nutritivo e oferece benefícios funcionais para o organismo humano. No entanto, seu uso na culinária ainda é limitado, principalmente devido à falta de conhecimento sobre suas propriedades. Além disso, a disponibilidade de cultivares para consumo humano é reduzida. Portanto, este estudo foi realizado em Botucatu, Brasil, com o objetivo de verificar o potencial de cultivares de soja-grão (SG) e soja de duplo propósito (SDP) para consumo como soja-hortaliça (SH). Assim, vagens foram colhidas no estádio R6, foram avaliados quanto os teores de compostos bioativos (compostos fenólicos totais, flavonoides, atividade antioxidante e proteínas) e de antinutricionais (nitratos, oxalato, alcaloides e taninos). A cultivares apresentaram mesmo teor de proteína, não diferindo estatisticamente entre si, bem como para nitrato e oxalato. O conteúdo de compostos fenólicos e atividade antioxidante total da cultivar SG, diferiu estatisticamente do conteúdo das cultivares SPD e SH, respectivamente. De acordo com os resultados, a cultivar SG, com colheita das vagens em R6, apresentou qualidade nutracêutica e teores de compostos antinutricionais compatível com as duas cultivares propostas para soja vegetal. RESUMO sojahortaliça hortaliça entanto limitado propriedades disso reduzida Portanto Botucatu Brasil sojagrão grão SG (SG SDP (SDP SH. SH . (SH) Assim R6 R totais flavonoides proteínas nitratos, nitratos (nitratos oxalato taninos. taninos taninos) proteína si respectivamente resultados vegetal (SH

ABSTRACT: Vegetable soybean has high nutritional value and offers functional benefits to human body. However, its use in cooking is still limited, mainly due to the lack of knowledge about its properties. In addition, the availability of cultivars for human consumption is reduced. Therefore, this study was conducted in Botucatu, Brazil, to assess the potential of grain soybean (GS) and dual-purpose soybean (DPS) cultivars for consumption as vegetable soybean (VS). Pods were harvested at R6 stage, and the contents of bioactive compounds (total phenolic compounds, flavonoids, antioxidant activity and proteins) and antinutritional components (nitrates, oxalate, alkaloids and tannins) were evaluated. The cultivars showed the same protein content, not differing statistically from each other, as well as for nitrate and oxalate. The content of phenolic compounds and total antioxidant activity of the SG cultivar differed statistically from the content of the DPS and VS cultivars, respectively. According to the results, the GS cultivar, with pods harvested at R6 stage, showed nutraceutical quality and contents of antinutritional compounds similar to those of the two cultivars proposed for the vegetable soybean. ABSTRACT body However limited properties addition reduced Therefore Botucatu Brazil (GS dualpurpose dual purpose (DPS VS. . (VS) R stage flavonoids proteins nitrates, nitrates (nitrates oxalate tannins evaluated other respectively results (VS

https://doi.org/10.1590/0103-8478cr20230518

Pseudomelanomas at a referral ocular oncology center in Brazil
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Guedes, Viviane Kely Costa

; Morales, Melina Correia

; Belfort Neto, Rubens

; Fernandes, Arthur Gustavo

Revista Brasileira de Oftalmologia

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2024, Volume 83 elocation e0032

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a frequência e o perfil epidemiológico, clínico e de imagem das lesões que simulam o melanoma de coroide. Métodos: Trata-se de estudo de revisão retrospectiva de prontuários de suspeita de lesões de melanoma de coroide de 2014 a 2020 no Setor de Oncologia Ocular da Universidade Federal de São Paulo. Foram avaliados dados demográficos, dados clínicos e exames complementares. Resultados: Um total de 104 pacientes (média de idade: 65,57 ± 13,18; 49,04% do sexo feminino) foram encaminhados ao nosso serviço com suspeita de melanoma de coroide. Destes, 32 (30,77%) foram classificados como pseudomelanoma, enquanto 72 (69,23%) tiveram diagnóstico confirmado de melanoma de coroide. Os casos de pseudomelanoma manifestaram-se em indivíduos mais velhos (p < 0,001) e apresentaram lesões menores em altura (p < 0,001), diâmetro anteroposterior (p = 0,008) e diâmetro lateral (p = 0,003) na ultrassonografia. Os casos de pseudomelanoma estão associados a maiores frequências de hemorragia vítrea (p = 0,014) e menores taxas de presença de massa (p = 0,001) e descolamento de retina (p < 0,001). Os principais diagnósticos dos casos de pseudomelanoma foram nevo (40,63%), hemorragia sub-retiniana (18,75%) e membrana neovascular coroidal (18,75%). Conclusão: Quase um terço dos casos encaminhados com suspeita de melanoma de coroide foram pseudomelanomas, o que demonstra que ainda há um caminho considerável para melhorar a habilidade do oftalmologista geral em discriminar clinicamente o melanoma de outras condições que o simulam. Objetivo epidemiológico Métodos Tratase Trata se 201 202 Paulo demográficos complementares Resultados 10 média idade 6557 65 57 65,5 13,18 1318 13 18 4904 49 04 49,04 feminino Destes 3 30,77% 3077 30 77 (30,77% 7 69,23% 6923 69 23 (69,23% manifestaramse manifestaram p 0,001 0001 0 001 0,001, , 0,008 0008 008 0,003 0003 003 ultrassonografia 0,014 0014 014 0,001. . 40,63%, 4063 40,63% 40 63 (40,63%) subretiniana sub retiniana 18,75% 1875 75 (18,75% 18,75%. Conclusão pseudomelanomas 20 1 655 6 5 65, 13,1 131 490 4 49,0 30,77 307 (30,77 69,23 692 2 (69,23 0,00 000 00 0,01 01 406 40,63 (40,63% 18,75 187 (18,75 13, 49, 30,7 (30,7 69,2 (69,2 0,0 40,6 (40,63 18,7 (18,7 30, (30, 69, (69, 0, 40, (40,6 18, (18, (30 (69 (40, (18 (3 (6 (40 (1 ( (4

ABSTRACT Objective: To evaluate the epidemiological, clinical, and imaging profile of lesions that mimic choroidal melanoma. Methods: Retrospective study of medical records of suspected choroidal melanoma lesions referred to the Ocular Oncology Service from the Universidade Federal de São Paulo, from 2014 to 2020. Demographic data, clinical history, and exams were evaluated. Results: A total of 104 patients (mean age: 65.57 ± 13.18; 49.04% female) were referred to our service with suspected choroidal melanoma. Of these, 32 (30.77%) were classified as pseudomelanoma, while 72 (69.23%) had a confirmed diagnosis of choroidal melanoma. Pseudomelanoma cases manifested in older individuals (p < 0.001), with smaller lesions in height (p < 0.001), anteroposterior diameter (p = 0.008), and lateral diameter (p = 0.003) on ultrasound. Pseudomelanoma cases were associated with higher frequencies of vitreous hemorrhage (p = 0.014) and lower rates of the presence of a mass (p = 0.001) and retinal detachment (p < 0.001). The main diagnoses of pseudomelanoma cases were choroidal nevus (40.63%), subretinal hemorrhage (18.75%) and choroidal neovascular membrane (18.75%). Conclusion: Almost one third of the cases referred with suspected choroidal melanoma were pseudomelanomas, which demonstrates that there is still a considerable path to improve the ability of general ophthalmologists to clinically discriminate melanoma from other conditions that can mimic it. Objective epidemiological Methods Paulo 201 2020 data history evaluated Results 10 mean age 6557 65 57 65.5 13.18 1318 13 18 4904 49 04 49.04 female these 3 30.77% 3077 30 77 (30.77% 7 69.23% 6923 69 23 (69.23% p 0.001, 0001 0.001 , 0 001 0.008, 0008 0.008 008 0.008) 0.003 0003 003 ultrasound 0.014 0014 014 0.001. . 40.63%, 4063 40.63% 40 63 (40.63%) 18.75% 1875 75 (18.75% 18.75%. Conclusion pseudomelanomas it 20 202 1 655 6 5 65. 13.1 131 490 4 49.0 30.77 307 (30.77 69.23 692 2 (69.23 000 0.00 00 0.01 01 406 40.63 (40.63% 18.75 187 (18.75 13. 49. 30.7 (30.7 69.2 (69.2 0.0 40.6 (40.63 18.7 (18.7 30. (30. 69. (69. 0. 40. (40.6 18. (18. (30 (69 (40. (18 (3 (6 (40 (1 ( (4

https://doi.org/10.37039/1982.8551.20240032

Eye-related emergency visits during the early phase of the coronavirus disease pandemic in a reference hospital in Sao Paulo, Brazil Eyerelated Eye related Paulo
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Schapira, Evandro

; Fernandes, Rodrigo Antonio Brant

; Fernandes, Arthur Gustavo

Arquivos Brasileiros de Oftalmologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

may 2023, Volume 86 N. 3 Pages 206 - 209

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivos: Avaliar o perfil das consultas de emergência oftalmológicas durante os primeiros meses de quarentena por pandemia de covid-19 em um hospital oftalmológico de referência em São Paulo e compará-lo com o mesmo período do ano anterior. Métodos: Os dados foram extraídos do serviço de emergência do Hospital Ophthal Especializado, São Paulo, Brasil. Todos os casos registrados entre 23 de março e 19 de maio de 2020 foram incluídos no estudo como Grupo 2020. Os casos registrados entre 23 de março e 19 de maio de 2019 foram incluídos no estudo como Grupo de 2019. Tabelas de frequência foram utilizadas para análises descritivas. Os testes Qui-quadrado e Exato de Fisher foram aplicados para comparar variáveis categóricas entre os grupos. Resultados: Observamos uma diminuição de 46,15% no número de casos durante a pandemia Covid-19 em 2020 quando comparado ao mesmo período sem pandemia em 2019. Foi observado um aumento significativo nos achados de pálpebra (+12,3%), córnea (+97,1%), retina (+173,1%), refração (+62,9%), glaucoma (+43,9%), esclera (+68,8%), trauma (+39,3%), herpes (+54,7%) e catarata (+549,9%) em 2020 quando comparado para 2019. Por outro lado, houve redução nos casos de conjuntivite (-33,4%), transtornos do aparelho lacrimal (-81,0%), iridociclite (-39,9%) e consultas pós-operatórias (-80,1%). Conclusão: durante a fase inicial da pandemia Covid-19, foi observada uma redução drástica no número de pacientes que procuram o serviço de emergência ocular. Houve também uma mudança nos principais motivos para visitas com frequências mais altas de casos de alta gravidade como distúrbios da retina, distúrbios da córnea, glaucoma e trauma, e frequências mais baixas de condições transmissíveis como conjuntivite. Objetivos covid19 covid covid-1 comparálo compará lo anterior Métodos Especializado Brasil 2 1 202 201 descritivas Quiquadrado Qui quadrado grupos Resultados 4615 46 15 46,15 Covid19 Covid Covid-1 +12,3%, 123 +12,3% , 12 3 (+12,3%) +97,1%, 971 +97,1% 97 (+97,1%) +173,1%, 1731 +173,1% 173 (+173,1%) +62,9%, 629 +62,9% 62 9 (+62,9%) +43,9%, 439 +43,9% 43 (+43,9%) +68,8%, 688 +68,8% 68 8 (+68,8%) +39,3%, 393 +39,3% 39 (+39,3%) +54,7% 547 54 7 (+54,7% +549,9% 5499 549 (+549,9% lado 33,4%, 334 33,4% 33 4 (-33,4%) 81,0%, 810 81,0% 81 0 (-81,0%) 39,9% 399 (-39,9% pósoperatórias pós operatórias 80,1%. 801 80,1% . 80 (-80,1%) Conclusão Covid19, 19, ocular covid1 covid- 20 461 46,1 Covid1 Covid- +12,3 (+12,3% +97,1 (+97,1% +173,1 17 (+173,1% +62,9 6 (+62,9% +43,9 (+43,9% +68,8 (+68,8% +39,3 (+39,3% +54,7 5 (+54,7 +549,9 (+549,9 33,4 (-33,4% 81,0 (-81,0% 39,9 (-39,9 80,1 (-80,1% 46, +12, (+12,3 +97, (+97,1 +173, (+173,1 +62, (+62,9 +43, (+43,9 +68, (+68,8 +39, (+39,3 +54, (+54, +549, (+549, 33, (-33,4 81, (-81,0 39, (-39, 80, (-80,1 +12 (+12, +97 (+97, +173 (+173, +62 (+62, +43 (+43, +68 (+68, +39 (+39, +54 (+54 +549 (+549 (-33, (-81, (-39 (-80, +1 (+12 +9 (+97 +17 (+173 +6 (+62 +4 (+43 (+68 +3 (+39 +5 (+5 (-33 (-81 (-3 (-80 + (+1 (+9 (+17 (+6 (+4 (+3 (+ (-8 (- (

ABSTRACT Purpose: To evaluate the profile of emergency eye-related visits at a reference eye hospital in Sao Paulo during the first months of the quarantine due to the coronavirus disease (COVID-19) pandemic and to compare it with that in the same period of the previous year. Methods: Data were obtained from the emergency department of Ophthal Hospital Especializado, Sao Paulo, Brazil. All the cases registered between March 23 and May 19, 2020, were included in the study as Group 2020. The cases registered between March 23 and May 19, 2019, were included in the study as Group 2019. Frequency tables were used for the descriptive analyses. The chi-square and Fisher exact tests were applied to compare categorical variables between the groups. Results: We observe a decrease of 46.15% in the number of cases during the COVID-19 pandemic in 2020 compared with the same period in 2019. We observed a significant increase in the incidence rates of the following pathologies in 2020 compared with 2019: eyelid disorders (12.3%), corneal disorders (97.1%), retinal pathologies (173.1%), refraction (62.9%), glaucoma (acute and chronic; 43.9%), scleral alterations (68.8%), trauma (39.3%), herpes (54.7%), and cataracts (549.9%). On the other hand, the incidence rates of the following disorders decreased: conjunctivitis (-33.4%), disorders of lacrimal system (-81.0%), iridocyclitis (-39.9%), and postoperative visits (-80.1%). Conclusion: During the early phase of the COVID-19 pandemic, we observed a drastic decrease in the number of patients who visited the emergency eye service. The main reasons for visiting were also changed, with higher frequencies of high-severity cases such as retina disturbances, cornea disturbances, glaucoma, and trauma and lower frequencies of transmittable conditions such as conjunctivitis. Purpose eyerelated related COVID19 COVID 19 (COVID-19 year Methods Especializado Brazil 2 2019 analyses chisquare chi square groups Results 4615 46 15 46.15 COVID-1 202 12.3%, 123 12.3% , 12 3 (12.3%) 97.1%, 971 97.1% 97 1 (97.1%) 173.1%, 1731 173.1% 173 (173.1%) 62.9%, 629 62.9% 62 9 (62.9%) acute chronic 43.9%, 439 43.9% 43 43.9%) 68.8%, 688 68.8% 68 8 (68.8%) 39.3%, 393 39.3% 39 (39.3%) 54.7%, 547 54.7% 54 7 (54.7%) 549.9%. 5499 549.9% . 549 (549.9%) hand decreased 33.4%, 334 33.4% 33 4 (-33.4%) 81.0%, 810 81.0% 81 0 (-81.0%) 39.9%, 399 39.9% (-39.9%) 80.1%. 801 80.1% 80 (-80.1%) Conclusion service changed highseverity high severity disturbances COVID1 (COVID-1 201 461 46.1 COVID- 20 12.3 (12.3% 97.1 (97.1% 173.1 17 (173.1% 62.9 6 (62.9% 43.9 68.8 (68.8% 39.3 (39.3% 54.7 5 (54.7% 549.9 (549.9% 33.4 (-33.4% 81.0 (-81.0% 39.9 (-39.9% 80.1 (-80.1% (COVID- 46. 12. (12.3 97. (97.1 173. (173.1 62. (62.9 43. 68. (68.8 39. (39.3 54. (54.7 549. (549.9 33. (-33.4 81. (-81.0 (-39.9 80. (-80.1 (COVID (12. (97. (173. (62. (68. (39. (54. (549. (-33. (-81. (-39. (-80. (12 (97 (173 (62 (68 (39 (54 (549 (-33 (-81 (-39 (-80 (1 (9 (17 (6 (3 (5 (-3 (-8 ( (-

https://doi.org/10.5935/0004-2749.20230041

The impact of the COVID-19 pandemic on the diagnosis and treatment of ocular cancer COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Fontes Junior, Vicente Conrado

; Fernandes, Arthur Gustavo

; Morales, Melina Correa

; Belfort Neto, Rubens

Arquivos Brasileiros de Oftalmologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

apr 2023, Volume 86 N. 2 Pages 127 - 130

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar o impacto do isolamento social devido à pandemia COVID-19 sobre o número de casos novos e abordagens terapêuticas. Métodos: Estudo retrospectivo por revisões de prontuários de novos pacientes tratados antes da pandemia, de março de 2019 a setembro de 2019 (grupo pré-pandemia), e durante a pandemia, de março de 2020 a setembro de 2020 (grupo pandemia). Dados analisados incluíram idade, sexo, etnia, local de origem, diagnóstico clínico, tempo desde o encaminhamento e terapia proposta. Resultados: Um total de 186 novos casos foram analisados, sendo 122 do grupo pré-Pandemia e 64 do grupo Pandemia, representando uma redução de 47,54%. Não houve alteração estatisticamente signi ficativa quanto a sexo, raça, estado de origem, história do câncer, idade ou tempo de encaminhamento (p>0,05). Observou-se maior frequência de malignidades no grupo pandemia (68%) quando comparado com o grupo pré-pandemia (48,48%). Os tumores benignos foram os casos mais diagnosticados no grupo pré-pandemia (41,80%), enquanto no grupo pandemia o diagnóstico mais frequente foi o carcinoma de células escamosas de conjuntiva (31,25%). Houve tendência (p=0,097) de diminuição no número de cirurgias (-7,63%) e de aumento no tratamento tópico (+10,68%). Houve também uma tendência a diminuição de indicação cirúrgica em tumores benignos e diminuição dos retornos imediatos. Conclusão: Nossos achados mostram uma diminuição significativa no número de novos casos encaminhados ao setor de Oncologia Ocular. Além disso, a pandemia levou a uma mudança na abordagem terapêutica com preferência a tratamentos não invasivos, a fim de evitar o uso de salas de cirurgia. Um aumento drástico de casos, talvez em estágios avançados, pode ser esperado como resultado da diminuição observada nos primeiros 6 meses de quarentena. Objetivo COVID19 COVID 19 COVID-1 terapêuticas Métodos 201 prépandemia, prépandemia pré , pré-pandemia) 202 pandemia. . pandemia) sexo etnia origem clínico proposta Resultados 18 12 préPandemia Pandemia 4754 47 54 47,54% raça câncer p>0,05. p005 p p>0,05 0 05 (p>0,05) Observouse Observou se 68% 68 (68% 48,48%. 4848 48,48% 48 (48,48%) 41,80%, 4180 41,80% 41 80 (41,80%) 31,25%. 3125 31,25% 31 25 (31,25%) p=0,097 p0097 097 (p=0,097 7,63% 763 7 63 (-7,63% +10,68%. 1068 +10,68% 10 (+10,68%) imediatos Conclusão Ocular disso invasivos cirurgia avançados quarentena COVID1 1 COVID- 20 475 4 5 47,54 p00 p>0,0 (p>0,05 (68 484 48,48 (48,48% 418 41,80 8 (41,80% 312 31,25 3 2 (31,25% p=0,09 p009 09 (p=0,09 7,63 76 (-7,63 106 +10,68 (+10,68% 47,5 p0 p>0, (p>0,0 (6 48,4 (48,48 41,8 (41,80 31,2 (31,25 p=0,0 (p=0,0 7,6 (-7,6 +10,6 (+10,68 47, p>0 (p>0, ( 48, (48,4 41, (41,8 31, (31,2 p=0, (p=0, 7, (-7, +10, (+10,6 p> (p>0 (48, (41, (31, p=0 (p=0 (-7 +10 (+10, (p> (48 (41 (31 p= (p= (- +1 (+10 (p (4 (3 + (+1 (+

ABSTRACT Purpose: To evaluate the impact of social isolation due to the COVID-19 pandemic on the number of new cases and therapeutic approaches at the Ocular Oncology division from the Universidade Federal de São Paulo (UNIFESP). Methods: A retrospective study was conducted by medical records review of new patients treated before the pandemic from March 2019 to September 2019 (pre-pandemic group) and during the pandemic from March 2020 to September 2020 (pandemic group). Data regarding age, sex, ethnicity, place of origin, clinical diagnosis, time since referral, and proposed therapy were analyzed. Results: We analyzed 186 new cases, 122 from the pre-pandemic group and 64 from the pandemic group, representing a decrease of 47.54% in new cases. There was no statistically significant change in sex, race, state of origin, history of cancer, age, or time with suspected cancer (p>0.05). A higher frequency of malignancies was observed in the pandemic group (68%) when compared to the pre-pandemic group (48.48%). Benign tumors were the most common diagnosis in the pre-pandemic group (41.80%), while conjunctival squamous cell carcinoma was the modal diagnosis in the pandemic group (31.25%). There was a decreasing trend (p=0.097) in the number of surgeries (-7.63%) and an increase in topical treatment (+10.68%). There was also a tendency to perform fewer surgeries in benign tumors and decreased follow-up visits. Conclusion: Our findings showed a significant decrease in the number of new cases referred to the Ocular Oncology service. Moreover, the pandemic led to a switch in the therapeutic approach with preference to non-invasive treatments that would demand operating rooms. A drastic increase of cases perhaps in advanced stages might be expected because of the decrease observed in the first six months of quarantine. Purpose COVID19 COVID 19 COVID-1 UNIFESP. UNIFESP . (UNIFESP) Methods 201 prepandemic pre 202 group. age sex ethnicity origin referral Results 18 12 6 4754 47 54 47.54 race p>0.05. p005 p p>0.05 0 05 (p>0.05) 68% 68 (68% 48.48%. 4848 48.48% 48 (48.48%) 41.80%, 4180 41.80% , 41 80 (41.80%) 31.25%. 3125 31.25% 31 25 (31.25%) p=0.097 p0097 097 (p=0.097 7.63% 763 7 63 (-7.63% +10.68%. 1068 +10.68% 10 (+10.68%) followup follow up visits Conclusion service Moreover noninvasive non invasive rooms quarantine COVID1 1 COVID- (UNIFESP 20 475 4 5 47.5 p00 p>0.0 (p>0.05 (68 484 48.48 (48.48% 418 41.80 8 (41.80% 312 31.25 3 2 (31.25% p=0.09 p009 09 (p=0.09 7.63 76 (-7.63 106 +10.68 (+10.68% 47. p0 p>0. (p>0.0 (6 48.4 (48.48 41.8 (41.80 31.2 (31.25 p=0.0 (p=0.0 7.6 (-7.6 +10.6 (+10.68 p>0 (p>0. ( 48. (48.4 41. (41.8 31. (31.2 p=0. (p=0. 7. (-7. +10. (+10.6 p> (p>0 (48. (41. (31. p=0 (p=0 (-7 +10 (+10. (p> (48 (41 (31 p= (p= (- +1 (+10 (p (4 (3 + (+1 (+

https://doi.org/10.5935/0004-2749.20230023

The effects of the Covid-19 pandemic on eye-related emergency visits Covid19 Covid 19 Covid-1 eyerelated eye related Covid1 1 Covid-
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Fowler, Julia de Avila

; Fernandes, Arthur Gustavo

; Almeida, Rafael Cunha de

; Veiga, Glaucia Luciano da

; Fonseca, Fernando Luiz Affonso

; Lima, Vagner Loduca

Revista Brasileira de Oftalmologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

2023, Volume 82 elocation e0046

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo Avaliar os efeitos da pandemia da Covid-19 no perfil dos atendimentos oftalmológicos de emergência e comparar os achados com os do período anterior à pandemia. Métodos Estudo transversal realizado ao longo de 1 ano em um hospital oftalmológico de referência. Casos registrados no Complexo Hospitalar Municipal de Emergências de Santo André (SP, Brasil) entre março de 2019 e fevereiro de 2020 foram incluídos no estudo como Grupo Pré-Pandemia. Os casos registrados entre março de 2020 e fevereiro de 2021 foram incluídos no Grupo Pandemia. Os casos foram classificados de acordo com a Classificação Internacional de Doenças e Problemas Relacionados à Saúde. Resultados Houve redução de 52,1% no número de atendimentos oftalmológicos de emergência durante o período pandêmico (n=9.198) quando comparado ao pré-pandêmico (n=19.220), com reduções significativas em casos inespecíficos (-98,1%), visitas pós-operatórias (-67,0%), distúrbios da conjuntiva (-54,1%), filme lacrimal (-49,4%) e refração (-85,6%) durante o período de pandemia. Condições como distúrbios da retina (+202,7%), distúrbios da esclera (+76,2%), distúrbios da órbita (+20,2%), glaucoma (+66,6%) e trauma (+19,4%) apresentaram taxas aumentadas, bem como aquelas relacionadas a pálpebras (+186,9%), córnea (+33,4%), úvea (+40,2%) e herpes (+55,3%). Conclusão Observou-se drástica redução no número de atendimentos oftalmológicos durante a pandemia da Covid-19, delineando um novo perfil de atendimento, com maior frequência de quadros que levam à baixa de visão e à menor frequência de diagnósticos contagiosos e inespecíficos. Covid19 Covid 19 Covid-1 referência SP, SP (SP Brasil 201 202 PréPandemia. PréPandemia Pré Pandemia Pré-Pandemia Saúde 521 52 52,1 n=9.198 n9198 n 9 198 (n=9.198 prépandêmico pré n=19.220, n19220 n=19.220 , 220 (n=19.220) 98,1%, 981 98,1% 98 (-98,1%) pósoperatórias pós operatórias 67,0%, 670 67,0% 67 0 (-67,0%) 54,1%, 541 54,1% 54 (-54,1%) 49,4% 494 49 4 (-49,4% 85,6% 856 85 6 (-85,6% +202,7%, 2027 +202,7% 7 (+202,7%) +76,2%, 762 +76,2% 76 2 (+76,2%) +20,2%, +20,2% 20 (+20,2%) +66,6% 666 66 (+66,6% +19,4% 194 (+19,4% aumentadas +186,9%, 1869 +186,9% 186 (+186,9%) +33,4%, 334 +33,4% 33 (+33,4%) +40,2% 402 40 (+40,2% +55,3%. 553 +55,3% . 55 3 (+55,3%) Observouse Observou se Covid19, 19, atendimento Covid1 Covid- 5 52, n=9.19 n919 (n=9.19 n1922 n=19.22 22 (n=19.220 98,1 (-98,1% 67,0 (-67,0% 54,1 (-54,1% 49,4 (-49,4 85,6 8 (-85,6 +202,7 (+202,7% +76,2 (+76,2% +20,2 (+20,2% +66,6 (+66,6 +19,4 (+19,4 +186,9 18 (+186,9% +33,4 (+33,4% +40,2 (+40,2 +55,3 (+55,3% n=9.1 n91 (n=9.1 n192 n=19.2 (n=19.22 98, (-98,1 67, (-67,0 54, (-54,1 49, (-49, 85, (-85, +202, (+202,7 +76, (+76,2 +20, (+20,2 +66, (+66, +19, (+19, +186, (+186,9 +33, (+33,4 +40, (+40, +55, (+55,3 n=9. n9 (n=9. n19 n=19. (n=19.2 (-98, (-67, (-54, (-49 (-85 +202 (+202, +76 (+76, +20 (+20, +66 (+66 +19 (+19 +186 (+186, +33 (+33, +40 (+40 +55 (+55, n=9 (n=9 n1 n=19 (n=19. (-98 (-67 (-54 (-4 (-8 (+202 +7 (+76 +2 (+20 +6 (+6 +1 (+1 +18 (+186 +3 (+33 +4 (+4 +5 (+55 n= (n= n=1 (n=19 (-9 (-6 (-5 (- + (+7 (+2 (+ (+18 (+3 (+5 (n (n=1 (

ABSTRACT Objective To evaluate the effects of the Covid-19 pandemic on the profile of emergency eye-related visits and compare the findings with the same period before the pandemic. Methods Cross-sectional study performed during one year at a reference eye hospital. Cases registered at the emergency Municipal Hospital Complex of Santo Andre, Brazil, between March, 2019 and February, 2020 were included in the study as the Pre-pandemic group. Cases registered between March, 2020 and February, 2021 were included as the Pandemic group. Cases were classified according to the International Classification of Diseases ICD-10 and Related Health Problems. Results There was a decrease of 52.1% in the emergency eye care visits during the pandemic period (n=9,198) when compared to the pre-pandemic period (n=19,220), with significant reductions in nonspecific cases (-98.1%), postoperative visits (-67.0%), disorders of the conjunctiva (-54.1%), tear film (-49.4%) and refraction (-85.6%) during the pandemic period. Conditions such as retina disorders (+202.7%), sclera disorders (+76.2%), orbit disorders (+20.2%), glaucoma (+66.6%) and trauma (+19.4%) have shown increased rates, as well as those related to eyelids (+186.9%), cornea (+33.4%), uvea (+40.2%), and herpes (+55.3%). Conclusion A drastic reduction in the number of eye-related emergency visits was observed during the Covid-19 pandemic, outlining a new profile of care, with higher frequency of sight-threatening conditions and lower frequency of contagious and non-specific diagnosis. Covid19 Covid 19 Covid-1 eyerelated Crosssectional Cross sectional hospital Andre Brazil March 201 February 202 Prepandemic Pre group ICD10 ICD 10 ICD-1 Problems 521 52 1 52.1 n=9,198 n9198 n 9 198 (n=9,198 prepandemic pre n=19,220, n19220 n=19,220 , 220 (n=19,220) 98.1%, 981 98.1% 98 (-98.1%) 67.0%, 670 67.0% 67 0 (-67.0%) 54.1%, 541 54.1% 54 (-54.1%) 49.4% 494 49 4 (-49.4% 85.6% 856 85 6 (-85.6% +202.7%, 2027 +202.7% 7 (+202.7%) +76.2%, 762 +76.2% 76 2 (+76.2%) +20.2%, +20.2% 20 (+20.2%) +66.6% 666 66 (+66.6% +19.4% 194 (+19.4% rates +186.9%, 1869 +186.9% 186 (+186.9%) +33.4%, 334 +33.4% 33 (+33.4%) +40.2%, 402 +40.2% 40 (+40.2%) +55.3%. 553 +55.3% . 55 3 (+55.3%) sightthreatening sight threatening non specific diagnosis Covid1 Covid- ICD1 ICD- 5 52. n=9,19 n919 (n=9,19 n1922 n=19,22 22 (n=19,220 98.1 (-98.1% 67.0 (-67.0% 54.1 (-54.1% 49.4 (-49.4 85.6 8 (-85.6 +202.7 (+202.7% +76.2 (+76.2% +20.2 (+20.2% +66.6 (+66.6 +19.4 (+19.4 +186.9 18 (+186.9% +33.4 (+33.4% +40.2 (+40.2% +55.3 (+55.3% n=9,1 n91 (n=9,1 n192 n=19,2 (n=19,22 98. (-98.1 67. (-67.0 54. (-54.1 49. (-49. 85. (-85. +202. (+202.7 +76. (+76.2 +20. (+20.2 +66. (+66. +19. (+19. +186. (+186.9 +33. (+33.4 +40. (+40.2 +55. (+55.3 n=9, n9 (n=9, n19 n=19, (n=19,2 (-98. (-67. (-54. (-49 (-85 +202 (+202. +76 (+76. +20 (+20. +66 (+66 +19 (+19 +186 (+186. +33 (+33. +40 (+40. +55 (+55. n=9 (n=9 n1 n=19 (n=19, (-98 (-67 (-54 (-4 (-8 (+202 +7 (+76 +2 (+20 +6 (+6 +1 (+1 +18 (+186 +3 (+33 +4 (+40 +5 (+55 n= (n= n=1 (n=19 (-9 (-6 (-5 (- + (+7 (+2 (+ (+18 (+3 (+4 (+5 (n (n=1 (

https://doi.org/10.37039/1982.8551.20230046

10.

Scleral communication between Glaucoma drainage device capsule and the suprachoroidal space simulating amelanotic choroidal melanoma
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Queiroz, Diego

; Lustosa, Gustavo Porto

; Mascato, Diego

; Morales, Melina Correia

; Fernandes, Arthur Gustavo

; Fernandes, Rodrigo Antonio Brant

Arquivos Brasileiros de Oftalmologia

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2023, Volume 86 N. 6 elocation e20230073

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Relato de caso de paciente 56 anos, sexo masculino, com histórico de vitrectomia via pars plana por descolamento de retina em olho direito e posterior implante de dispositivo de drenagem por glaucoma secundário. Dois anos após o procedimento foi encaminhado ao serviço por baixa de acuidade visual (AV) de 20/200 (1.00 LogMAR). À fundoscopia, observou-se uma elevação amelanótica temporal no equador com hipótese diagnóstica de melanoma de coroide amelanótico. O exame de ultrassom mostrou implante de dispositivo de drenagem justabulbar temporal superior com comunicação transescleral para espaço subcoroidal (fístula), sugerindo bolsão focal de descolamento de coroide em equador temporal superior simulando melanoma de coroide amelanótico. O paciente foi abordado cirurgicamente devido membrana epirretiniana com nova vitrectomia via pars plana para peeling de membrana limitante interna, sem repercussões no local da fístula, evoluindo bem com acuidade visual de 20/70 (0.55 LogMAR). Ao nosso conhecimento, este é o primeiro caso relatado nessa condição. 5 masculino secundário AV (AV 20200 20 200 20/20 1.00 100 1 00 (1.0 LogMAR. LogMAR . LogMAR) fundoscopia observouse observou se amelanótico fístula , (fístula) interna 2070 70 20/7 0.55 055 0 55 (0.5 conhecimento condição 2020 2 20/2 1.0 10 (1. (fístula 207 7 20/ 0.5 05 (0. 202 1. (1 0. (0 (

ABSTRACT This is a case report involving a 56-year-old male patient with a history of pars plana vitrectomy due to a rhegmatogenous retinal detachment in the right eye that resulted in the implantation of a drainage device after the patient developed secondary glaucoma. Two years after the device’s implantation, the patient was referred to our care as his visual acuity had decreased to 20/200 (1.00 LogMAR). At the fundus evaluation, a choroidal amelanotic elevation was observed at the upper temporal equator, and a potential diagnosis was made of amelanotic choroidal melanoma. The ultrasound exam visualized the patient’s implanted superotemporal justabulbar drainage device, which revealed a transscleral communication from the plate fibrocapsular’s draining space to the suprachoroidal space (fistula). The ultrasound also revealed a focal pocket of choroidal detachment in the patient’s superotemporal region, simulating an amelanotic choroidal melanoma. A new pars plana vitrectomy was performed to remove the internal limiting membrane without repercussions at the fistula site. The patient’s recovery progressed well, and he regained a visual acuity of 20/70 (0.55 LogMAR). To the best of our knowledge, this is the first case report of this condition. 56yearold yearold 56 year old glaucoma devices s 20200 20 200 20/20 1.00 100 1 00 (1.0 LogMAR. LogMAR . LogMAR) evaluation equator melanoma patients fibrocapsulars fibrocapsular fistula. (fistula) region site well 2070 70 20/7 0.55 055 0 55 (0.5 knowledge condition 5 2020 2 20/2 1.0 10 (1. (fistula 207 7 20/ 0.5 05 (0. 202 1. (1 0. (0 (

https://doi.org/10.5935/0004-2749.20230073

11.

Scorpion envenomation in Brazil: an update
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Fernandes Barbosa Parrela, Arthur

; Rodrigues, Raquel Roque

; Campos, Gustavo de Paula

; Miranda Gomes, Ana Clara

; de S. Lima Rodrigues, Bruna Soares

; Melo Braga, Marcella N.

; Ribeiro Júnior, Ademir N.

; Siqueira-Batista, Rodrigo

Infectio

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jun 2022, Volume 26 N. 2 Pages 172 - 180

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Los accidentes causados por escorpiones representan un problema mayor de salud pública tanto en términos de daños individuales como en la esfera de la salud pública. Los eventos mórbidos pueden ocurrir con diferentes manifestaciones y condiciones clínicas que deben ser diferenciadas para un manejo adecuado. Ade más del daño potencial que ocasionan a los humanos, el veneno del escorpión ha sido estudiado con el fin de analizar su potencia aplicación para le tratamiento de algunas enfermedades. Este articulo presenta una actualización sobre los aspectos clínicos, terapéuticos y profilácticos del escorpionismo.

Abstract Accidents caused by scorpions represent a major health problem on planet, both in individual terms and in the public health sphere. Morbid events can occur in different manifestations, and different clinical conditions must be differentiated for adequate treatment. In addition to the potential injury to human hosts, scorpion venom has been investigated for the therapy of several illnesses. Based on these aspects, the present article aims to present the clinical, diagnostic, therapeutic and prophylactic aspects of scorpionism.

https://doi.org/10.22354/in.v26i2.1018 86 downloads

12.

Sebaceous adenoma of the conjunctiva and caruncle: a clinicopathological report of three cases and literature review
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Dias, Mariana Borges Barcellos

; Morales, Melina Correia

; Fernandes, Arthur Gustavo

; Rigueiro, Moacyr

; Odashiro, Alexandre Nakao

; Belfort Neto, Rubens Mattos

Arquivos Brasileiros de Oftalmologia

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apr 2022, Volume 85 N. 2 Pages 174 - 177

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Tumores sebáceos da conjuntiva e carúncula são condições raras, sendo mais encontrados nas pálpebras. O ade noma sebáceo é responsável por 1% das lesões carunculares e ainda menos frequente nas lesões da conjuntiva. Esse diagnóstico é de suma importância pois quase 50% desses pacientes podem ser diagnosticados com a Síndrome de Muir-Torre, uma condição autossômica dominante rara que é caracterizada pela presença de ao menos um tumor de pele sebáceo e uma neoplasia visceral (gastrointestinal, câncer geniturinário e de mama). O estudo tem como objetivo relatar 3 casos de adenoma sebáceo com diferentes apresentações, que foram submetidos a biópsia excisional e estudo imuno-histoquímico. O diagnóstico desses tumores deve levantar suspeitas e aconselhar a investigação clínica para descartar outras neoplasias, principalmente porque em até 41% dos casos esse pode ser o primeiro sinal da Síndrome de Muir-Torre.

ABSTRACT Sebaceous tumors of the conjunctiva and caruncle are rare conditions, accounting for 1% of caruncle lesions and even lower among conjunctival lesions. Almost 50% of cases are associated with Muir-Torre syndrome, a rare autosomal-dominant condition characterized by at least one sebaceous skin tumor and one visceral malignancy. We report 3 cases of sebaceous adenoma with different presentations that were submitted to excisional biopsy and immunohistochemical study. Diagnosis of these tumors should increase the level of suspicion and lead to clinical investigation to rule out neoplasms, particularly because in up to 41% of cases, these can be the first sign of the disease.

https://doi.org/10.5935/0004-2749.20220023

13.

Scleral communication between Glaucoma drainage device capsule and the suprachoroidal space simulating amelanotic choroidal melanoma
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Queiroz, Diego

; Lustosa, Gustavo Porto

; Mascato, Diego

; Morales, Melina Correia

; Fernandes, Arthur Gustavo

; Fernandes, Rodrigo Antonio Brant

Arquivos Brasileiros de Oftalmologia

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2022, N. ahead

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.5935/0004-2749.20230073

14.

Equivalent keratometer reading para cálculo biométrico em córneas assimétricas: série de casos
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Ferreira, Diego de Queiroz Tavares

; Meireles, Antônio Carlos

; Fernandes, Arthur Gustavo

; Fernandes, Rodrigo Antônio Brant

Revista Brasileira de Oftalmologia

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2022, Volume 81 elocation e0004

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A acurácia do cálculo da lente intraocular não é perfeita, podendo ser comuns erros refrativos pós-operatórios, especialmente em pacientes submetidos à cirurgia refrativa prévia ou na presença de córneas assimétricas. O poder corneano após cirurgia refrativa pode ser medido com maior acurácia utilizando o mapa de poder óptico total na zona central de 4mm, com Orbscan II ou pelo mapa equivalent keratometric reading disponível no pentacam, com medidas centrais de 1,0, 2,0, 3,0 e 4,5mm. O objetivo desta série de casos é demonstrar a abordagem de quatro olhos em condições especiais corneanas, por meio do equivalent keratometric reading do pentacam para mensuração do poder corneano e o utilizando na biometria, em comparação com possíveis resultados obtidos com outras estratégias. Os quatro olhos foram submetidos a procedimentos refrativos prévios, e a lente intraocular escolhida a partir do uso do poder corneano calculado pelo equivalent keratometric reading mostrou excelentes resultados pós-operatórios.

ABSTRACT The accuracy of the intraocular lens calculation is not perfect, and postoperative refractive errors are common, especially in patients who have undergone previous refractive surgery or in presence of asymmetric corneas. Corneal power after refractive surgery can be more accurately measured using the total optical power map in the 4-mm central zone, by means of Orbscan II or equivalent keratometric reading map available on pentacam, with central measurements of 1.0, 2.0, 3.0 and 4.5 mm. The purpose of this case series is to demonstrate four approaches performed in special corneal conditions, using pentacam equivalent keratometric reading to measure corneal power and biometrics, and comparing with possible results obtained with other strategies. The four eyes were submitted to previous refractive procedures, and the intraocular lens chosen from the use of the corneal power calculated by equivalent keratometric reading showed excellent postoperative results.

https://doi.org/10.37039/1982.8551.20220004

15.

COMVC-19: A Program to protect healthcare workers’ mental health during the COVID-19 Pandemic. What we have learned
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Fukuti, Pedro

; Uchôa, Caroline Louise Mesquita

; Mazzoco, Marina Flaborea

; Cruz, Isabella D'Andrea Garcia da

; Echegaray, Mariana V.F.

; Humes, Eduardo de Castro

; Silveira, Júlia Belizário

; Santi, Talita Di

; Miguel, Euripedes Constantino

; Corchs, Felipe

; Fatori, Daniel

; Campello, Guilherme

; Oliveira, Gabriel M. de

; Argolo, Felipe C.

; Ferreira, Felipe de M.

; Machado, Gustavo

; Argeu, Adriana

; Oliveira, Graça Maria Ramos de

; Serafim, Antônio de Pádua

; Siqueira, Luciana de Lima

; Rossi, Luciane de

; Rios, Izabel Cristina

; Oliveira, Talita Rodrigues de

; Antoniazzi, Leilane C. K.

; Gagliotti, Daniel Augusto Mori

; Abelama Neto, Emílio

; Oliveira Junior, Paulo Novais de

; Correia, Aline Villalobo

; Gonçalves, Luca Schilling

; Tortato, Liana Silva

; Busato, Wagner Machado Moraes

; Guimarães-Fernandes, Flávio

; Alves, Marcos

; Leite Netto, Oswaldo Ferreira

; Schoueri, Patrícia de Campos Lindenberg

; Roque, Márcio de Assis

; Merlin, Silvia Stahl

; Boer, Giovana Cardoso Machado

; Sallet, Paulo Clemente

; Malbergier, André

; Spedo, Mariana Abrahão

; Kamitsuji, Carla Satie

; Faria, Elizabeth de

; Moreira, Moacyr Vergara de Godoy

; Kaufman, Arthur

; Abdo, Carmita

; Scanavino, Marco de Tubino

; Lancman, Selma

; Tavares, Hermano

; Polanczyk, Guilherme

; Brunoni, André R.

; Forlenza, Orestes V.

; Barros-Filho, Tarcísio Eloy Pessoa de

Clinics

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2021, Volume 76 elocation e2631

Abstract: En | Text: En | PDF: En

OBJECTIVE: In 2020, the COVID-19 pandemic brought a work and stress overload to healthcare workers, increasing their vulnerability to mental health impairments. In response, the authors created the COMVC-19 program. The program offered preventive actions and mental health treatment for the 22,000 workers of The Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP). This paper aims to describe its implementation and share what we have learned from this experience. METHODS: Workers were able to easily access the program through a 24/7 hotline. Additionally, a mobile phone app that screened for signs and symptoms of emotional distress and offered psychoeducation and/or referral to treatment was made available. Data from both these sources as well as any subsequent psychiatric evaluations were collected. RESULTS: The first 20 weeks of our project revealed that most participants were female, and part of the nursing staff working directly with COVID-19 patients. The most frequently reported symptoms were: anxiety, depression and sleep disturbances. The most common diagnoses were Adjustment, Anxiety, and Mood disorders. CONCLUSIONS: Implementing a mental health program in a multimodal intervention was feasible in a major quaternary public hospital. Our data also suggests that preventive actions should primarily be aimed at anxiety and depression symptoms, with a particular focus on the nursing staff.

https://doi.org/10.6061/clinics/2021/e2631

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