Resumo Este estudo investigou a prevalência e potenciais fatores de risco para ansiedade e depressão em fisioterapeutas durante a pandemia. Fisioterapeutas responderam a um questionário na web, incluindo: dados sociodemográficos, profissionais e clínicos; demandas psicossociais; e dois questionários validados para medir ansiedade e depressão. Regressão logística binária identificou fatores de risco para ansiedade e depressão por meio de odds ratio (OR) e intervalo de confiança de 95% (IC). Em 417 participantes houve alta prevalência de ansiedade (48,2%) e depressão (53%). Os fatores de risco para ansiedade foram: sexo feminino (OR 2,07; IC95% 1,01-4,24), piora nos padrões de sono (OR 3,78; IC95% 1,92-7,44), moderada (OR 2,24; IC95% 1,00-5,00) e extrema preocupação financeira (OR 3,47; IC95% 1,57-7,65) e extrema solidão (OR 3,47; IC95% 1,71-7,07). Os fatores de risco para depressão foram: sexo feminino (OR 2,16; IC95% 1,03-4,55), baixa renda familiar (OR 2,43; IC95% 1,21-4,89), piora nos padrões de sono (OR 5,97; IC95% 3,02-11,82), extrema preocupação financeira (OR 2,61; IC95% 1,15-5,94) e extrema solidão (OR 4,38; IC95% 2,00-9,63). Este estudo mostrou alta prevalência de ansiedade e depressão na população estudada e identificou fatores de risco para ambos. pandemia web incluindo sociodemográficos clínicos psicossociais OR 95 IC. IC . (IC) 41 48,2% 482 48 2 (48,2% 53%. 53 53% (53%) foram 2,07 207 07 IC95 1,014,24, 101424 1,01 4,24 , 1 01 4 24 1,01-4,24) 3,78 378 3 78 1,927,44, 192744 1,92 7,44 92 7 44 1,92-7,44) 2,24 224 1,005,00 100500 1,00 5,00 00 5 1,00-5,00 3,47 347 47 1,577,65 157765 1,57 7,65 57 65 1,57-7,65 1,717,07. 171707 1,71 7,07 71 1,71-7,07) 2,16 216 16 1,034,55, 103455 1,03 4,55 03 55 1,03-4,55) 2,43 243 43 1,214,89, 121489 1,21 4,89 21 89 1,21-4,89) 5,97 597 97 3,0211,82, 3021182 3,02 11,82 02 11 82 3,02-11,82) 2,61 261 61 1,155,94 115594 1,15 5,94 15 94 1,15-5,94 4,38 438 38 2,009,63. 200963 2,00 9,63 9 63 2,00-9,63) ambos (IC 48,2 (48,2 (53% 2,0 20 0 IC9 014 1,014,24 10142 101 1,0 424 4,2 1,01-4,24 3,7 37 927 1,927,44 19274 192 1,9 744 7,4 1,92-7,44 2,2 22 005 1,005,0 10050 100 500 5,0 1,00-5,0 3,4 34 577 1,577,6 15776 157 1,5 765 7,6 6 1,57-7,6 717 1,717,07 17170 171 1,7 707 7,0 1,71-7,07 2,1 034 1,034,55 10345 103 455 4,5 1,03-4,55 2,4 214 1,214,89 12148 121 1,2 489 4,8 8 1,21-4,89 5,9 59 0211 3,0211,82 302118 302 3,0 1182 11,8 3,02-11,82 2,6 26 155 1,155,9 11559 115 1,1 594 1,15-5,9 4,3 009 2,009,63 20096 200 963 9,6 2,00-9,63 48, (48, (53 2, 1,014,2 1014 10 1, 42 4, 1,01-4,2 3, 1,927,4 1927 19 74 7, 1,92-7,4 1,005, 1005 50 5, 1,00-5, 1,577, 1577 76 1,57-7, 1,717,0 1717 17 70 1,71-7,0 1,034,5 1034 45 1,03-4,5 1,214,8 1214 12 1,21-4,8 021 3,0211,8 30211 30 118 11, 3,02-11,8 1,155, 1155 1,15-5, 2,009,6 2009 96 9, 2,00-9,6 (48 (5 1,014, 1,01-4, 1,927, 1,92-7, 1,005 1,00-5 1,577 1,57-7 1,717, 1,71-7, 1,034, 1,03-4, 1,214, 1,21-4, 3,0211, 3021 3,02-11, 1,155 1,15-5 2,009, 2,00-9, (4 ( 1,014 1,01-4 1,927 1,92-7 1,00- 1,57- 1,717 1,71-7 1,034 1,03-4 1,214 1,21-4 3,0211 3,02-11 1,15- 2,009 2,00-9 1,01- 1,92- 1,71- 1,03- 1,21- 3,021 3,02-1 2,00- 3,02-

Abstract This study investigated the prevalence and the potential risk factors for anxiety and depression among physiotherapists during the pandemic. Physiotherapists answered a web-based questionnaire including 1) sociodemographic, professional and clinical information; 2) psychosocial demands; and 3) two validated questionnaires to measure anxiety and depression. Binary logistic regression identified the risk factors by means of odds ratio (OR) and 95% confidence interval (CI). In 417 participants, there was a high prevalence of anxiety (48.2%) and depression (53.0%). The risk factors for anxiety were female sex (OR 2.07; 95%CI 1.01-4.24), worsening in sleep patterns (OR 3.78; 95%CI 1.92-7.44), moderate (OR 2.24; 95%CI 1.00-5.00) and extreme concern about financial issues (OR 3.47; 95%CI 1.57-7.65), and extreme loneliness (OR 3.47; 95%CI 1.71-7.07). The risk factors for depression were female sex (OR 2.16; 95%CI 1.03-4.55), low family income (OR 2.43; 95%CI 1.21-4.89), worsening in sleep patterns (OR 5.97; 95%CI 3.02-11.82), extreme concern about financial issues (OR 2.61; 95%CI 1.15-5.94), and extreme loneliness (OR 4.38; 95%CI 2.00-9.63). This study found a high prevalence of anxiety and depression in the studied population and identified risk factors for both. pandemic webbased web based 1 sociodemographic information 2 demands 3 OR 95 CI. CI . (CI) 41 participants 48.2% 482 48 (48.2% 53.0%. 530 53.0% 53 0 (53.0%) 2.07 207 07 95CI 1.014.24, 101424 1.01 4.24 , 01 4 24 1.01-4.24) 3.78 378 78 1.927.44, 192744 1.92 7.44 92 7 44 1.92-7.44) 2.24 224 1.005.00 100500 1.00 5.00 00 5 1.00-5.00 3.47 347 47 1.577.65, 157765 1.57 7.65 57 65 1.57-7.65) 1.717.07. 171707 1.71 7.07 71 1.71-7.07) 2.16 216 16 1.034.55, 103455 1.03 4.55 03 55 1.03-4.55) 2.43 243 43 1.214.89, 121489 1.21 4.89 21 89 1.21-4.89) 5.97 597 97 3.0211.82, 3021182 3.02 11.82 02 11 82 3.02-11.82) 2.61 261 61 1.155.94, 115594 1.15 5.94 15 94 1.15-5.94) 4.38 438 38 2.009.63. 200963 2.00 9.63 9 63 2.00-9.63) both (CI 48.2 (48.2 53.0 (53.0% 2.0 20 014 1.014.24 10142 101 1.0 424 4.2 1.01-4.24 3.7 37 927 1.927.44 19274 192 1.9 744 7.4 1.92-7.44 2.2 22 005 1.005.0 10050 100 500 5.0 1.00-5.0 3.4 34 577 1.577.65 15776 157 1.5 765 7.6 6 1.57-7.65 717 1.717.07 17170 171 1.7 707 7.0 1.71-7.07 2.1 034 1.034.55 10345 103 455 4.5 1.03-4.55 2.4 214 1.214.89 12148 121 1.2 489 4.8 8 1.21-4.89 5.9 59 0211 3.0211.82 302118 302 3.0 1182 11.8 3.02-11.82 2.6 26 155 1.155.94 11559 115 1.1 594 1.15-5.94 4.3 009 2.009.63 20096 200 963 9.6 2.00-9.63 48. (48. 53. (53.0 2. 1.014.2 1014 10 1. 42 4. 1.01-4.2 3. 1.927.4 1927 19 74 7. 1.92-7.4 1.005. 1005 50 5. 1.00-5. 1.577.6 1577 76 1.57-7.6 1.717.0 1717 17 70 1.71-7.0 1.034.5 1034 45 1.03-4.5 1.214.8 1214 12 1.21-4.8 021 3.0211.8 30211 30 118 11. 3.02-11.8 1.155.9 1155 1.15-5.9 2.009.6 2009 96 9. 2.00-9.6 (48 (53. 1.014. 1.01-4. 1.927. 1.92-7. 1.005 1.00-5 1.577. 1.57-7. 1.717. 1.71-7. 1.034. 1.03-4. 1.214. 1.21-4. 3.0211. 3021 3.02-11. 1.155. 1.15-5. 2.009. 2.00-9. (4 (53 1.014 1.01-4 1.927 1.92-7 1.00- 1.577 1.57-7 1.717 1.71-7 1.034 1.03-4 1.214 1.21-4 3.0211 3.02-11 1.155 1.15-5 2.009 2.00-9 ( (5 1.01- 1.92- 1.57- 1.71- 1.03- 1.21- 3.021 3.02-1 1.15- 2.00- 3.02-

Resumo Este estudo investigou a prevalência e potenciais fatores de risco para ansiedade e depressão em fisioterapeutas durante a pandemia. Fisioterapeutas responderam a um questionário na web, incluindo: dados sociodemográficos, profissionais e clínicos; demandas psicossociais; e dois questionários validados para medir ansiedade e depressão. Regressão logística binária identificou fatores de risco para ansiedade e depressão por meio de odds ratio (OR) e intervalo de confiança de 95% (IC). Em 417 participantes houve alta prevalência de ansiedade (48,2%) e depressão (53%). Os fatores de risco para ansiedade foram: sexo feminino (OR 2,07; IC95% 1,01-4,24), piora nos padrões de sono (OR 3,78; IC95% 1,92-7,44), moderada (OR 2,24; IC95% 1,00-5,00) e extrema preocupação financeira (OR 3,47; IC95% 1,57-7,65) e extrema solidão (OR 3,47; IC95% 1,71-7,07). Os fatores de risco para depressão foram: sexo feminino (OR 2,16; IC95% 1,03-4,55), baixa renda familiar (OR 2,43; IC95% 1,21-4,89), piora nos padrões de sono (OR 5,97; IC95% 3,02-11,82), extrema preocupação financeira (OR 2,61; IC95% 1,15-5,94) e extrema solidão (OR 4,38; IC95% 2,00-9,63). Este estudo mostrou alta prevalência de ansiedade e depressão na população estudada e identificou fatores de risco para ambos.

Abstract This study investigated the prevalence and the potential risk factors for anxiety and depression among physiotherapists during the pandemic. Physiotherapists answered a web-based questionnaire including 1) sociodemographic, professional and clinical information; 2) psychosocial demands; and 3) two validated questionnaires to measure anxiety and depression. Binary logistic regression identified the risk factors by means of odds ratio (OR) and 95% confidence interval (CI). In 417 participants, there was a high prevalence of anxiety (48.2%) and depression (53.0%). The risk factors for anxiety were female sex (OR 2.07; 95%CI 1.01-4.24), worsening in sleep patterns (OR 3.78; 95%CI 1.92-7.44), moderate (OR 2.24; 95%CI 1.00-5.00) and extreme concern about financial issues (OR 3.47; 95%CI 1.57-7.65), and extreme loneliness (OR 3.47; 95%CI 1.71-7.07). The risk factors for depression were female sex (OR 2.16; 95%CI 1.03-4.55), low family income (OR 2.43; 95%CI 1.21-4.89), worsening in sleep patterns (OR 5.97; 95%CI 3.02-11.82), extreme concern about financial issues (OR 2.61; 95%CI 1.15-5.94), and extreme loneliness (OR 4.38; 95%CI 2.00-9.63). This study found a high prevalence of anxiety and depression in the studied population and identified risk factors for both.

Abstract Objective: To compare the Rapid Shallow Breathing Index (RSBI) obtained by the ventilometer and from mechanical ventilation parameters. Methods: Randomized crossover trial, including 33 intubated patients, on mechanical ventilation for at least 24 hours, undergoing spontaneous breathing test. Patients were submitted to the measurement of RSBI by four methods: disconnected from the ventilator through the ventilometer; in Pressure Support Ventilation (PSV) mode at a pressure of 7 cm H2O; in Continuous Positive Airway Pressure (CPAP) mode at a pressure of 5 cmH2O with flow trigger; in CPAP mode at a pressure of 5 cmH2O with pressure trigger. Results: No significant difference was detected between the RSBI obtained by the ventilometer and in the CPAP mode with flow and pressure triggers, however, in the PSV mode, the values were lower than in the other measurements (p < 0.001). By selecting patients from the sample with higher RSBI (≥ 80 cycles.min−1.L−1), the value of the index obtained by the ventilometer was higher than that obtained in the three options of ventilation methods. Conclusion: The RSBI obtained in the CPAP mode at a pressure of 5 cmH2O, in both triggers types, did not differ from that measured by the ventilometer; it is, therefore, an alternative when obtaining it from mechanical ventilation parameters is necessary. However, in the presence of borderline values, the RSBI measured by ventilometer is recommended, as in this method the values are significantly higher than in the three ventilation modalities investigated. Objective (RSBI Methods trial 3 2 hours test methods (PSV H2O HO H O (CPAP cmHO cmH trigger Results however p 0.001. 0001 0.001 . 0 001 0.001) ≥ ( 8 cycles.min−1.L−1, cyclesmin1L1 cyclesminL cycles.min−1.L−1 , cycles min 1 L cycles.min−1.L−1) Conclusion types therefore necessary However recommended investigated 000 0.00 00 cyclesmin cyclesmin1L cycles.min−1.L− 0.0 cycles.min−1.L 0.

RESUMO CONTEXTO: A cirrose hepática é uma doença altamente prevalente que, em estágio avançado, geralmente causa ascite e alterações respiratórias associadas. No entanto, existem poucos estudos avaliando e quantificando o impacto da ascite e do seu alívio através da paracentese na função pulmonar e em sintomas como fadiga e dispneia em pacientes cirróticos. OBJETIVO: Avaliar e quantificar o impacto da redução aguda do volume ascítico nos parâmetros respiratórios, sintomas de fadiga e dispneia em pacientes com cirrose hepática, bem como investigar possíveis correlações entre esses parâmetros. MÉTODOS: Trinta pacientes com cirrose hepática e ascite foram submetidos às seguintes avaliações pré e pós-paracentese: sinais vitais, padrão respiratório, mobilidade toracoabdominal (cirtometria), função pulmonar (ventilometria), grau de dispneia (escala numérica) e nível de fadiga (escala visual analógica). RESULTADOS: Houve maior prevalência de pacientes classificados como CHILD B e o escore MELD médio foi de 14,73±5,75. A comparação dos parâmetros pré e pós paracentese evidenciou após a paracentese: aumento do padrão respiratório predominantemente abdominal, melhora das variáveis ventilatórias, aumento das diferenças obtidas na cirtometria axilar e abdominal, redução do nível de dispneia e fadiga, redução da pressão arterial e aumento da saturação periférica de oxigênio. Correlações positivas encontradas: cirtometria xifoide com axilar, grau de dispneia com nível de fadiga, volume corrente com volume minuto, CHILD “C” com maior escore MELD, volume drenado na paracentese com maior escore MELD e com CHILD “C”. Também observamos uma correlação negativa entre volume corrente e a frequência respiratória. CONCLUSÃO: Uma vez que a drenagem da ascite em pacientes com cirrose hepática melhora os volumes pulmonares e a expansão torácica, além de reduzir sintomas como fadiga e dispneia, podemos concluir que a ascite tem um impacto respiratório e sintomatológico negativo nesses pacientes.

ABSTRACT BACKGROUND: Liver cirrhosis is a highly prevalent disease that, at an advanced stage, usually causes ascites and associated respiratory changes. However, there are few studies evaluating and quantifying the impact of ascites and its relief through paracentesis on lung function and symptoms such as fatigue and dyspnea in cirrhotic patients. OBJECTIVE: To assess and quantify the impact of acute reduction of ascitic volume on respiratory parameters, fatigue and dyspnea symptoms in patients with hepatic cirrhosis, as well as to investigate possible correlations between these parameters. METHODS: Thirty patients with hepatic cirrhosis and ascites who underwent the following pre and post paracentesis evaluations: vital signs, respiratory pattern, thoracoabdominal mobility (cirtometry), pulmonary function (ventilometry), degree of dyspnea (numerical scale) and fatigue level (visual analog scale). RESULTS: There was a higher prevalence of patients classified as CHILD B and the mean MELD score was 14.73±5.75. The comparison of pre and post paracentesis parameters evidenced after paracentesis: increase of predominantly abdominal breathing pattern, improvement of ventilatory variables, increase of the differences obtained in axillary and abdominal cirtometry, reduction of dyspnea and fatigue level, blood pressure reduction and increased peripheral oxygen saturation. Positive correlations found: xiphoid with axillary cirtometry, degree of dyspnea with fatigue level, tidal volume with minute volume, Child “C” with higher MELD score, volume drained in paracentesis with higher MELD score and with Child “C”. We also observed a negative correlation between tidal volume and respiratory rate. CONCLUSION: Since ascites drainage in patients with liver cirrhosis improves pulmonary volumes and thoracic expansion as well as reduces symptoms such as fatigue and dyspnea, we can conclude that ascites have a negative respiratory and symptomatological impact in these patients.

RESUMO Objetivos Moléculas inflamatórias e fatores neurotróficos estão implicados na modulação dolorosa, contudo, seu papel nas cefaleias primárias não é claro. O objetivo do presente estudo foi comparar níveis de biomarcadores séricos na migrânea e cefaleia do tipo tensional. Métodos Este foi um estudo transversal, no qual foram avaliados níveis de adiponectina, quimiocinas e fatores neurotróficos em pacientes com migrânea e cefaleia do tipo tensional. Sintomas depressivos e ansiosos, o impacto e a frequência da cefaleia e alodínea foram registrados. Resultados Foram incluídos 68 pacientes com migrânea e 48 pacientes com cefaleia do tipo tensional. A alodínia cutânea (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), e adiponectina (p = 0.017) foram maiores na migrânea, independentemente de sintomas depressivos e ansiosos, frequência e impacto da cefaleia. Conclusões Níveis de CCL3/MIP-1α, CCL5/RANTES e adiponectina foram maiores na migrânea do que na cefaleia do tipo tensional, sugerindo papeis distintos destas moléculas na fisiopatologia destas duas cefaleias primárias.

ABSTRACT Objectives Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.

Objective: To investigate the respiratory and postural adaptations associated with mouth and nasal breathing and to evaluate the associations of such adaptations in mouth breathers' self-perceived quality of life. Method: Cross-sectional study with mouth breathers (initial n=116 and final n=48) and nasal breathers (initial n=131 and final n=24) from elementary school, aged between 7 and 14 years. Chest expansion, using cirtometry, the breathing pattern and the use of accessory muscles, by means of clinical evaluations and photogrammetry, and flexibility tests were evaluated in both groups. Subsequently, the mouth breathers were asked to complete the quality of life questionnaire. Statistical tests: Chi-square, odds ratio, Mann-Whitney, and binomial tests were first applied followed by logistic regressions. Results: Thoracic breathing (p=0.04), using of accessory muscles (p=0.03) and reductions in flexibility (p=0.001) increased the chances of an individual being a mouth breather when compared to nasal breathers. Subsequently, using of accessory muscles decreased the chances of snoring among mouth breathers (p=0.03); the presence of shoulder asymmetry reduced the chances of experiencing quiet sleep (p=0.05) and increased the chances of coughing or being tired when playing or running (p=0.008). Finally, forward head position reduced the chances of waking up at night (p=0.04) and experiencing shortness of breath (p=0.05). Conclusions: Respiratory and postural adaptations increased the chances of individuals persisting with mouth breathing. Additionally, these adaptations could be associated with mouth breathers' self-perceived quality of life.

Os fatores neurotróficos (FN) participam da regulação da dor e podem ter um papel na fisiopatologia das cefaleias peimárias. O objetivo do presente estudo foi avaliar os níveis séricos de FN em pacientes com cefaleia do tipo tensional (CTT). Foi realizado corte transversal com 48 pacientes com CTT e 48 controles pareados por gênero e idade. Os inventários de Beck para depressão e ansiedade, bem como o inventário de impacto da cefaleia foram aplicados. Os níveis séricos de FN foram determinados por ELISA. Não houve diferenças significativas entre níveis de FN entre pacientes com TTH e controles, bem como entre pacientes com TTH episódica e crônica. Presença de cefaleia no momento da avaliação não alterou os níveis séricos de FN. Os escores de depressão, ansiedade e impacto da cefaleia não se correlacionaram com os níveis de FN. Nosso estudo sugere que não há alteração dos níveis de FN na TTH.

Neurotrophic factors (NF) are involved in pain regulation and a few studies have suggested that they may play a pathophysiological role in primary headaches. The aim of this study was to investigate NF levels in patients with tension type headache (TTH). We carried out a cross sectional study including 48 TTH patients and 48 age and gender matched controls. Beck Depression and Anxiety Inventories, and Headache Impact Test were recorded. Serum levels of NF were determined by ELISA. There were not significant differences between NF levels between TTH patients and controls. Patients with chronic and episodic TTH had not significant differences in NF levels. The presence of headache at the time of evaluation did not significantly alter the levels of NF. Depression and anxiety scores as well as headache impact did not correlate with NF levels. Our study suggest that the serum levels of NF are not altered in TTH.

Objetivo: Este estudo avaliou o consumo problemático de álcool em pacientes com migrânea e em pacientes com cefaleia do tipo tensional. Método: Foram avaliados 81 pacientes com migrânea e 62 pacientes com cefaleia do tipo tensional. A avaliação do consumo de álcool foi realizada com o Teste para Identificação de Problemas Relacionados ao Uso de Álcool (AUDIT), sendo considerado consumo problemático quando o escore do AUDIT foi igual ou maior que 8. O impacto funcional da cefaleia foi avaliado pelo Teste de Impacto da Cefaleia (HIT-6). Resultados: As proporções de desordens relacionadas ao álcool entre pacientes com migrânea e cefaleia do tipo tensional foram 5,2% e 16,1%, respectivamente (P=0,044). O impacto funcional foi significativamente maior na migrânea que na cefaleia do tipo tensional (P<0,0001). Houve significativa correlação entre comprometimento funcional da cefaleia e os escores do AUDIT (P=0,043). Conclusões: Nossos resultados sugerem que pacientes com migrânea têm menor probabilidade de apresentar consumo problemático do álcool que pacientes com cefaleia do tipo tensional. Uma das possíveis explicações é que o impacto funcional da cefaleia é maior na migrânea que na cefaleia do tipo tensional.

Objective: The aim of this study was to assess alcohol use problems in patients with migraine and tension-type headache. Method: We evaluated 81 patients with migraine and 62 patients with tension-type headache. The identification of alcohol consumption problems was carried out with Alcohol Use Disorders Identification Test (AUDIT). Alcohol use problem was defined as an AUDIT score of 8 or above. The headache impact was calculated with headache impact test (HIT-6). Results: The proportions of alcohol use problem among patients with migraine and tension-type headache were 5.2% and 16.1%, respectively (P=0.044). The headache impact was significantly higher with migraine than with tension-type headache (P<0.0001). There was an inverse correlation between headache impact and AUDIT (P=0.043). Conclusions: Our results suggest that migraine patients are less prone to alcohol use problems than tension-type headache patients. One of the possible reasons is that migraine is associated with greater impact than tension-type headache.