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Resumo Fundamento As complicações cardiovasculares da COVID-19 são aspectos importantes da patogênese e do prognóstico da doença. Evidências do papel prognóstico da troponina e da lesão miocárdica em pacientes hospitalizados com COVID-19 na América Latina são ainda escassos. Objetivos Avaliar a lesão miocárdica como preditor independente de mortalidade hospitalar e suporte ventilatório mecânico em pacientes hospitalizados, do registro brasileiro de COVID-19. Métodos Este estudo coorte é um subestudo do registro brasileiro de COVID-19, conduzido em 31 hospitais brasileiros de 17 cidades, de março a setembro de 2020. Os desfechos primários incluíram mortalidade hospitalar e suporte ventilatório mecânico invasivo. Os modelos para os desfechos primários foram estimados por regressão de Poisson com variância robusta, com significância estatística de p<0,05. Resultados Dos 2925 pacientes [idade mediana de 60 anos (48-71), 57,1%], 27,3% apresentaram lesão miocárdica. A proporção de pacientes com comorbidades foi maior nos pacientes com lesão miocárdica [mediana 2 (1-2) vs. 1 (0-20)]. Os pacientes com lesão miocárdica apresentaram maiores valores medianos de peptídeo natriurético cerebral, lactato desidrogenase, creatina fosfoquinase, N-terminal do pró-peptídeo natriurético tipo B e proteína C reativa em comparação a pacientes sem lesão miocárdica. Como fatores independentes, proteína C reativa e contagem de plaquetas foram relacionados com o risco de morte, e neutrófilos e contagem de plaquetas foram relacionados ao risco de suporte ventilatório mecânico invasivo. Os pacientes com níveis elevados de troponina apresentaram um maior risco de morte (RR 2,03, IC95% 1,60-2,58) e suporte ventilatório mecânico (RR 1,87;IC95% 1,57-2,23), em comparação àqueles com níveis de troponina normais. Conclusão Lesão cardíaca foi um preditor independente de mortalidade hospitalar e necessidade de suporte ventilatório mecânico em pacientes hospitalizados com COVID-19. COVID19 COVID 19 COVID-1 doença escassos COVID19. 19. COVID19, 19, 3 cidades 2020 invasivo robusta p005 p 0 05 p<0,05 292 idade 6 4871, 4871 48 71 , (48-71) 57,1%, 571 57,1% 57 57,1%] 273 27 27,3 12 (1-2 vs 020. 020 20 . (0-20)] cerebral desidrogenase fosfoquinase Nterminal N terminal própeptídeo pró independentes RR 203 03 2,03 IC95 IC 1,602,58 160258 1,60 2,58 58 1,60-2,58 1,87IC95% 187IC95 1,87 87 1,87;IC95 1,572,23, 157223 1,57 2,23 23 1,57-2,23) normais COVID1 COVID- 202 p00 p<0,0 29 487 4 7 (48-71 57,1 5 27, (1- 02 (0-20) 2,0 IC9 602 1,602,5 16025 160 1,6 258 2,5 1,60-2,5 87IC95 1,87IC95 187IC9 187 1,8 8 1,87;IC9 572 1,572,23 15722 157 1,5 223 2,2 1,57-2,23 p0 p<0, (48-7 57, (1 (0-20 2, 1,602, 1602 16 1, 25 1,60-2, 87IC9 1,87IC9 187IC 18 1,87;IC 1,572,2 1572 15 22 1,57-2,2 p<0 (48- ( (0-2 1,602 1,60-2 87IC 1,87IC 1,572, 1,57-2, p< (48 (0- 1,60- 1,572 1,57-2 (4 (0 1,57-

Abstract Background Cardiovascular complications of COVID-19 are important aspects of the disease’s pathogenesis and prognosis. Evidence on the prognostic role of troponin and myocardial injury in Latin American hospitalized COVID-19 patients is still scarce. Objectives To evaluate myocardial injury as independent predictor of in-hospital mortality and invasive mechanical ventilation support in hospitalized patients, from the Brazilian COVID-19 Registry. Methods This cohort study is a substudy of the Brazilian COVID-19 Registry, conducted in 31 Brazilian hospitals of 17 cities, March-September 2020. Primary outcomes included in-hospital mortality and invasive mechanical ventilation support. Models for the primary outcomes were estimated by Poisson regression with robust variance, with statistical significance of p<0.05. Results Of 2,925 patients (median age of 60 years [48-71], 57.1% men), 27.3% presented myocardial injury. The proportion of patients with comorbidities was higher among patients with cardiac injury (median 2 [1-2] vs. 1 [0-2]). Patients with myocardial injury had higher median levels of brain natriuretic peptide, lactate dehydrogenase, creatine phosphokinase, N-terminal pro-brain natriuretic peptide, and C-reactive protein than patients without myocardial injury. As independent predictors, C-reactive protein and platelet counts were related to the risk of death, and neutrophils and platelet counts were related to the risk of invasive mechanical ventilation support. Patients with high troponin levels presented a higher risk of death (RR 2.03, 95% CI 1.60-2.58) and invasive mechanical ventilation support (RR 1.87, 95% CI 1.57-2.23), when compared to those with normal troponin levels. Conclusion Cardiac injury was an independent predictor of in-hospital mortality and the need for invasive mechanical ventilation support in hospitalized COVID-19 patients. COVID19 COVID 19 COVID-1 diseases disease s prognosis scarce inhospital hospital Registry 3 cities MarchSeptember March September 2020 variance p005 p 0 05 p<0.05 2925 925 2,92 6 4871, 4871 48 71 , [48-71] 571 57 57.1 men, men men) 273 27 27.3 12 [1-2 vs 02. 02 . [0-2]) peptide dehydrogenase phosphokinase Nterminal N terminal probrain pro Creactive C reactive predictors RR 203 03 2.03 95 1.602.58 160258 1.60 2.58 58 1.60-2.58 187 87 1.87 1.572.23, 157223 1.57 2.23 23 1.57-2.23) COVID1 COVID- 202 p00 p<0.0 292 92 2,9 487 4 7 [48-71 5 57. 27. [1- [0-2] 20 2.0 9 602 1.602.5 16025 160 1.6 258 2.5 1.60-2.5 18 8 1.8 572 1.572.23 15722 157 1.5 223 2.2 1.57-2.23 p0 p<0. 29 2, [48-7 [1 [0-2 2. 1.602. 1602 16 1. 25 1.60-2. 1.572.2 1572 15 22 1.57-2.2 p<0 [48- [ [0- 1.602 1.60-2 1.572. 1.57-2. p< [48 [0 1.60- 1.572 1.57-2 [4 1.57-

https://doi.org/10.36660/abc.20220151

Changes in tactical behavior during small-sided and conditioned games performed within a training session
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Praça, Gibson Moreira

; Barbosa, Gustavo Fernandes

; Moreira, Pedro Emilio Drumond

; Sousa, Raphael Brito e

; Bredt, Sarah Glória Teles

; Chagas, Mauro Heleno

; Morales, Juan Carlos Pérez

; Greco, Pablo Juan

; Memmert, Daniel

Revista Brasileira de Cineantropometria & Desempenho Humano

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2020, Volume 22 elocation e71126

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do estudo foi verificar o efeito do pequeno jogo 3vs.3 sobre o comportamento tático de jovens jogadores de futebol em uma sessão de treinamento. Participaram do estudo 24 jogadores das categorias sub-13 e sub-14 de um clube professional. Realizaram-se quatro séries de quatro minutos do pequeno jogo 3vs.3 com quatro minutos de pausa passiva entre as séries. Todos os jogos foram filmados e analisou-se o comportamento tático por meio do Sistema de Avaliação Tática no Futebol. Foram comparados a frequência e o percentual de acertos dos princípios táticos nas quatro séries dentro de uma sessão de treinamento. Os resultados evidenciaram aumento do número das ações de unidade defensiva (p= 0.005; tamanho do efeito grande) e do percentual de acerto dos princípios defensivos (p<0.001; tamanho do efeito moderado). Conclui-se haver mudança do comportamento tático durante as séries de pequenos jogos realizados dentro de uma sessão de treinamento. Sugere-se que os jogadores adaptam seus comportamentos conforme os problemas táticos emergentes nos pequenos jogos. Além disso, sugere-se que a melhoria da capacidade tática de jogadores de futebol possa se basear nestas pequenas mudanças agudas do comportamento tático observadas dentro de cada sessão de treinamento.

Abstract This study aimed to verify the acute effects of 3vs.3 soccer small-sided and conditioned games (SSCG) on the tactical behavior of youth soccer athletes within one training session. Twenty-four soccer athletes (U-13 and U-14 categories) from a professional club participated in the study. They played four 4-minute 3vs.3 SSCG with 4 minutes of passive recovery in-between. All SSCG were recorded and players’ tactical behavior was analyzed using the System of Tactical Assessment in Soccer. We compared the frequencies and percentages of successful tactical principles over the four 3vs.3 SSCG bouts performed within the training session. Results showed an increased number of defensive unity actions (p= 0.005; large effect size) and a higher percentage of successful defensive principles (p<0.001; moderate effect size) in the fourth bout. We can conclude that players’ tactical behaviors change over the SSCG bouts performed within one training session. This suggests that players adapt their tactical behavior according to the tactical problems presented in the SSCG performed within the training session. We can suggest that the long-term improvement in the tactical skills of soccer athletes may be based on these small acute changes in tactical behavior observed in each training session.

https://doi.org/10.1590/1980-0037.2020v22e71126 910 downloads

Does the type of electrode affect the electromyoneurographic parameters in rats?
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Somensi, Danusa Neves

; Teixeira, Renan Kleber Costa

; Feijó, Daniel Haber

; Loureiro, Karine Drumond

; Valente, André Lopes

; Carvalho, Luan Teles Ferreira de

; Calvo, Faustino Chaves

; Santos, Deivid Ramos dos

; Barros, Rui Sergio Monteiro de

Acta Cirúrgica Brasileira

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2019, Volume 34 N. 3 elocation e201900304

Abstract: En | Text: En | PDF: En

Abstract Purpose: To evaluate if the type of electrode (needle vs. surface) affects the electromyoneurography parameters in rats. Methods: Twenty male rats were anesthetized, then compound muscle action potential were recorded using a Neuropack S1 MEB- 9400©. All animals were submitted to two electroneuromyography analysis: first with surface electrode and then by needle electrode. We evaluated the latency, amplitude, duration and area of the negative peak of the gastrocnemius and cranial tibial muscles. Results: There were no significant differences between the groups in the mean of duration, latency, amplitude or area of the negative peak in gastrocnemius and cranial tibial muscles. Conclusion: The type of electrode does not affect the electroneuromyography parameters.

https://doi.org/10.1590/s0102-865020190030000004 813 downloads

Circulation of Chikungunya virus East-Central-South Africa genotype during an outbreak in 2016-17 in Piaui State, Northeast Brazil
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Cardoso, Felipe Daniel

; Rezende, Izabela Mauricio de

; Barros, Emanuela Lima Teixeira

; Sacchetto, Lívia

; Garcês, Tereza Cristina de Carvalho Souza

; Silva, Natalia Ingrid Oliveira

; Alves, Pedro Augusto

; Soares, Jefferson Oliveira

; Kroon, Erna Geessien

; Pereira, Anna Carolina Toledo da Cunha

; Drumond, Betânia Paiva

; Ferreira, Gustavo Portela

Revista do Instituto de Medicina Tropical de São Paulo

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2019, Volume 61 elocation e57

Abstract: En | Text: En | PDF: En

ABSTRACT Chikungunya virus (CHIKV) is an arbovirus that emerged in the Americas in 2013. Infection with CHIKV is symptomatic in most of the cases and patients can develop chronic arthralgia that lasts from months to years in over 40% of the cases. The East-Central-South Africa (ECSA) genotype was introduced in Brazil in 2014, in Bahia State. Here we report the circulation of the CHIKV ECSA genotype in Piaui State, Northeast Brazil, during the years 2016-2017. The phylogenetic analysis revealed a single introduction of this lineage probably in 2015 and its maintenance at least until 2017. This analysis has also demonstrated the proximity of this genotype with isolates from neighboring States, and its partial nucleotide sequence of the viral E1 gene revealed a synapomorphy synonyms. This finding highlights the spread of the ECSA genotype in Brazil and supports its circulation in the Brazilian Northeast.

https://doi.org/10.1590/s1678-9946201961057 1169 downloads

Metabolic and histologic responses of pacu (Piaractus mesopotamicus) fed diets supplemented with increasing concentrations of ractopamine
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Drumond, Mariana Martins

; Naves, Luciana de Paula

; Ribeiro, Paula Adriane Perez

; Oliveira, Marinez Moraes de

; Okamura, Daniel

; Resende, Anaise Emanuele

; Cantarelli, Vinicius de Souza

; Rosa, Priscila Vieira

Revista Brasileira de Zootecnia

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2018, Volume 47 elocation e20160234

Abstract: En | Text: En | PDF: En

ABSTRACT An experiment was conducted during 60 days with forty pacu males fed diets supplemented with increasing concentrations of ractopamine (0.00, 11.25, 22.50, 33.75, and 45.00 mg kg−1). Eight fish were evaluated for each experimental diet. Performance and survival rate of the fish were measured. At the end of the experiment, blood was collected to determine the levels of cortisol, triacylglycerol, and protein. Moreover, the liver was collected to determine the activities of glucose-6-phosphate dehydrogenase and malic enzymes. The fillets were collected to determine chemical composition, and histologic cuts were analyzed to verify muscle growth and deposition of adipose tissue between muscle fibers. Increasing concentrations of dietary ractopamine did not change feed intake, fillet yield, fillet content of protein and ash, and frequency of relative distribution of muscle fibers. By increasing the dietary ractopamine concentration, the serum cortisol level was elevated. Ractopamine supplementation (45.00 mg kg−1) increased serum levels of triacylglycerol and protein and reduced the activity of hepatic lipogenic enzymes and the survival rate of the fish, probably in response to the high concentration of circulating cortisol. In addition, the higher level of ractopamine supplementation evaluated in this research impaired the weight gain and feed conversion. However, 11.25 mg kg−1 ractopamine reduced the ether extract level determined in the fillet and the fat deposition between muscle fibers, improving the nutritional quality of meat.

https://doi.org/10.1590/rbz4720160234 1211 downloads

Cutaneous and articular tuberculosis in a renal transplant recipient
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Moyses-Neto, Miguel

; Drumond, Daniel

; Morgantetti, Giuliano

; Garcia, Tania Maria Pisi

; Bolella, Valdes Roberto

; Romao, Elen Almeida

Revista da Sociedade Brasileira de Medicina Tropical

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aug 2017, Volume 50 N. 4 Pages 565 - 567

Abstract: En | Text: En | PDF: En

Abstract Seven months after undergoing kidney transplantation, a 56-year-old woman presented with papules and ulcers in her right forearm. The patient received antibiotics for 8 months with limited improvement. Eleven months after symptom onset, she presented with acute arthritis in her left knee. Asynovial fluid culture yielded Mycobacterium tuberculosis, and a forearm ulcer biopsy showed granulomatous inflammation. After surgical fistulectomy and 12 months of tuberculosis treatment, she was cured. Chronic cutaneous ulcers and articular manifestations in TB are rare, but they should always be considered in the differential diagnosis for immunosuppressed patients. Surgical intervention and prolonged treatment might be necessary.

https://doi.org/10.1590/0037-8682-0090-2016 761 downloads

Justiça distributiva no serviço de saúde especializado e no acesso a medicamentos
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Nobre, André Luiz Cândido Sarmento Drumond

; Dias, Orlene Veloso

; Leite, Maisa Tavares de Souza

; Freitas, Daniel de Melo

; Costa, Simone de Melo

Revista Bioética

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aug 2015, Volume 23 N. 2 Pages 373 - 386

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Quando se fala de doenças crônicas e do sistema público de saúde, a escassez de recursos está sempre em pauta. O estudo analisou o referenciamento e o acesso à medicação em indivíduos assistidos pelo serviço público estadual Hiperdia. Trata-se de pesquisa transversal, com 250 indivíduos referenciados para esse nível secundário de atenção à hipertensão e diabetes. Investigaram-se critérios biológicos, acesso aos medicamentos, perfil sociodemográfico e econômico e condição de saúde. O nível de significância estatística foi de 5%. O referenciamento correto foi de 64,0%, embora incorreto para quase metade dos que utilizaram o transporte público municipal. O acesso total à medicação (69,6%) estava associado à menor renda familiar (p < 0,05). A discussão, fundamentada no princípio da justiça distributiva, concluiu pela recomendação de melhor capacitação dos profissionais no referenciamento de serviços assistenciais, com redução do desperdício em transporte público e atenção especializada, além do que, tal investimento deve ser revertido em maior distribuição gratuita de medicamentos.

When speaking of chronic illnesses and the public health system, the lack of resources is on the agenda. The study analyzed the referencing and access to medication in individuals assisted by the State Public Service Hiperdia. It is a transversal study, with 250 individuals referred for this secondary level of attention to hypertension and diabetes. The study investigated biological criteria, access to medicine, socio-demographic and economic profile and health condition. The level of statistical significance was 5%. The correct referencing was 64.0%, although incorrect for nearly half of those that used municipal public transportation. The total access to medicine (69.6%) was associated with the lowest family incomes (p < 0.05). The discussion, based on the principle of distributive justice, was concluded by recommending better training of professionals in referencing assistance services, with a reduction of waste in public transport and specialized attention, because such investment should be reverted to a wider distribution of medicine.

Cuando se habla de enfermedades crónicas y sistema público de salud, la escasez de recursos está en agenda. El estudio analizó la derivación y el acceso a la medicación de individuos asistidos por el servicio público estatal Hiperdia. Se trata de un estudio transversal, con 250 individuos derivados hacia el nivel secundario, para la atención de hipertensión y diabetes. Se investigaron criterios biológicos, acceso a los medicamentos, perfil sociodemográfico y económico y condición de salud. El nivel de significación estadística fuel del 5%. La derivación correcta fue del 64,0%, aunque incorrecto para casi la mitad de los que utilizaron transporte público municipal. El acceso total a la medicación (69,6%) estuvo asociado al menor ingreso familiar (p < 0,05). La discusión, basada en el principio de la justicia distributiva, concluyó recomendando mejor capacitación de los profesionales en la derivación de servicios asistenciales, con reducción del gasto en transporte público y atención especializada, pues tal inversión debe ser traducida en mayor distribución gratuita de medicamentos.

https://doi.org/10.1590/1983-80422015232076 4941 downloads

Impacto dos fatores de risco para doenças crônicas não transmissíveis na qualidade de vida
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Oliveira-Campos, Maryane

; Rodrigues-Neto, João Felício

; Silveira, Marise Fagundes

; Neves, Daniele Malard Rocha

; Vilhena, Janine Moraes

; Oliveira, Juliana Fonseca

; Magalhães, Júlio César

; Drumond, Daniel

Ciência & Saúde Coletiva

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mar 2013, Volume 18 N. 3 Pages 873 - 882

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

A qualidade de vida tornou-se uma importante medida de impacto em saúde. Sua avaliação relacionada às doenças e seus fatores de risco tem acrescido na população em geral. Objetivo: Verificar a qualidade de vida e a presença de associação com fatores de risco para as doenças crônicas não transmissíveis na população urbana do município de Montes Claros, Minas Gerais. Métodos: Estudo transversal de base populacional. A amostra foi calculada considerando-se a prevalência do fator de risco sobrepeso de 30% e corrigida para um efeito de delineamento de 30%. Amostragem por conglomerados de setores censitários urbanos. Sorteou-se 17 setores censitários e entrevistou-se 648 moradores de idade maior ou igual a 18 anos. Os fatores de risco para as doenças crônicas não transmissíveis foram verificadas e a qualidade de vida também através do SF-36. Resultados: Alguns dos fatores de risco foram associados a piores escores no questionário SF-36. Conclusão: a presença de alguns fatores de risco para as doenças crônicas tem impacto na qualidade de vida.

Quality of life has become an important yardstick of the impact on health. Its evaluation related to diseases and associated risk factors has increased in the population in general. This article seeks to assess the quality of life and the presence of the association with risk factors for non-communicable chronic diseases in the urban population of the city of Montes Claros in the State of Minas Gerais. It is a population-based cross-sectional study. The sample was calculated considering the prevalence of risk factors of overweight of 30% and corrected for a variation of 30%. Cluster sampling was conducted on urban census sectors. Seventeen census sectors were selected and 648 residents aged e" 18 years were interviewed. The risk factors for non-communicable chronic diseases as well as the quality of life were verified using the SF-36 questionnaire. Some risk factors were associated with the lowest scores on the SF-36 questionnaire. The presence of some risk factors for chronic diseases has an impact on quality of life.

3745 downloads Cited 9 times in SciELO

Impacto dos fatores de risco para doenças crônicas não transmissíveis na qualidade de vida
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Oliveira-Campos, Maryane

; Rodrigues-Neto, João Felício

; Silveira, Marise Fagundes

; Neves, Daniele Malard Rocha

; Vilhena, Janine Moraes

; Oliveira, Juliana Fonseca

; Magalhães, Júlio César

; Drumond, Daniel

Ciência & Saúde Coletiva

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mar 2013, Volume 18 N. 3 Pages 873 - 882

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

11482 downloads Cited 9 times in SciELO

10.

Níveis de proteína bruta e energia metabolizável em uma linhagem de codorna de corte
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Veloso, Rogerio de Carvalho

; Pires, Aldrin Vieira

; Timpani, Vivian Dagnesi

; Drumond, Eduardo Silva Cordeiro

; Gonçalves, Flaviana Miranda

; Faria Filho, Daniel Emygdio de

Acta Scientiarum. Animal Sciences

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jun 2012, Volume 34 N. 2 Pages 169 - 174

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo deste trabalho foi estabelecer os níveis de proteína bruta e energia metabolizável para melhor desempenho em ganho de peso, peso corporal, consumo de ração e conversão alimentar em codornas de corte. Utilizaram-se 540 codornas de corte, durante três períodos experimentais: inicial (1 ao 21 dia), crescimento (22 ao 35 dia) e terminação (36 ao 49 dia). Os tratamentos foram constituídos pela combinação de cinco níveis de proteína bruta (18, 20, 22, 24 e 26% de PB) com três níveis de energia (2.700, 2.900 e 3.100 kcal EM kg-1), distribuídos em três blocos. Os modelos de regressão por superfície de resposta foram adotados como método de análise estatística. A melhor conversão alimentar ocorreu na fase de crescimento (22 ao 35 dia) independente do nível de energia utilizado na ração das codornas. Maiores níveis de energia (em torno de 3.000 kcal kg-1) e maiores níveis de proteína bruta proporcionam melhor ganho de peso. Nas fases inicial e de crescimento, as codornas de corte não apresentam diferença no peso corporal em função do nível de PB da ração. No entanto, na fase de terminação, as codornas apresentaram melhor peso corporal para os níveis mais elevados de proteína bruta.

This study aimed to establish the levels of crude protein and metabolizable energy for improved weight gain, body weight, feed intake and feed conversion in meat quails. A total of 540 quails were used during three experimental periods: baseline (1 to 21st day), growth (22nd to 35th day) and finishing (36 to 49th day). The treatments were a combination with five levels of crude protein (18, 20, 22, 24 and 26% CP) and three energy levels (2,700; 2,900 and 3,100 kcal kg-1), divided into three blocks. Regression models for response surface were used as the method of statistical analysis. Feed conversion occurred in the growth phase (22nd to 35th day) regardless of the energy level in the diet of quails. Higher levels of energy (around 3,000 kcal kg-1) and higher protein levels provided the best weight gain. In the baseline and growth stages, the quails did not differ in body weight according to diet CP level. However, at the finishing stage, the quails showed improved body weight for the highest levels of crude protein.

https://doi.org/10.4025/actascianimsci.v34i2.12589 2096 downloads Cited 7 times in SciELO

11.

Elderly and drugs: risks and necessity of rational use
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Baldoni, André de Oliveira

; Chequer, Farah Maria Drumond

; Ferraz, Elisa Raquel Anastácio

; Oliveira, Danielle Palma de

; Pereira, Leonardo Régis Leira

; Dorta, Daniel Junqueira

Brazilian Journal of Pharmaceutical Sciences

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dec 2010, Volume 46 N. 4 Pages 617 - 632

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Durante as últimas décadas, o mundo passou por uma transformação demográfica, com um rápido crescimento da população idosa e, portanto, tanto a demanda para a manutenção da saúde deste grupo populacional, quanto o consumo de medicamentos estão aumentando. Ainda, as mudanças farmacocinéticas e farmacodinâmicas que ocorrem em idosos podem interferir diretamente nos efeitos adversos dos medicamentos e aumentar o risco de intoxicação. Além disso, há fatores externos que interferem na farmacoterapia dos idosos, tais como o uso inadequado e a falta de acesso à informação. Existem várias classes terapêuticas de medicamentos que devem ser utilizados com cautela ou evitados na população idosa, tais como antiinflamatórios, alguns anti-hipertensivos, diuréticos, digitálicos entre outros. Estes medicamentos, se não forem utilizados com cuidado, podem afetar a qualidade de vida e a segurança desta população. Assim, este trabalho visa identificar medicamentos que devem ser utilizados com cuidado em pacientes idosos para evitar intoxicações e/ou eventos adversos aos medicamentos.

In recent decades, the world has undergone a demographic transformation with a rapid growth of the elderly population, resulting in an increased demand for funds to maintain their health and drug consumption. Pharmacokinetic and pharmacodynamic changes occurring in the elderly can interfere directly in the adverse effects of drugs and increase the risk of intoxication. In addition, there are external factors interfering with the pharmacotherapy of the elderly, such as inappropriate use and the lack of access to information. Many therapeutic classes of drugs should be used with caution or avoided in the elderly population, such as anti-inflammatory and some anti-hypertensive drugs, diuretics and digitalis. If not managed carefully, these medicines can affect the safety and quality of life in the elderly. Thus, the aim of this review was to identify drugs that should be used with caution in elderly patients in order to avoid intoxication and/or adverse drug events.

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