RESUMO: O estudo teve por objetivo determinar os benefícios de preparos mecânicos do solo na redução dos impedimentos físicos e seus reflexos no estabelecimento, no desenvolvimento e na produtividade de grãos de soja, além de quantificar a demanda energética ao trator para as operações. O experimento foi conduzido a campo no delineamento de blocos ao acaso em esquema bifatorial (6x2). O fator A foi composto por diferentes preparos do solo realizados no período de entressafra da soja, semeando apenas com o mesmo mecanismo de deposição do fertilizante, e por áreas sem preparo do solo semeadas com diferentes mecanismos de deposição do fertilizante da semeadora, sendo eles: (A1) semeadura sem preparo do solo (SSPS)+disco duplo na semeadora (DD); (A2) SSPS+disco turbo (DT); (A3) SSPS+haste sulcadora (HS); (A4) grade aradora+DD; (A5) escarificado+DD e (A6) subsolado+DD. Os preparos do solo anteriores a semeadura foram realizados 52 e 98 dias antes da semeadura, respectivamente, na primeira e segunda safra. O fator B foi composto por duas cultivares de soja, sendo elas: (B1) Nidera 6601 e (B2) Brasmax Valente. Não houve interação entre os fatores estudados. A escarificação+DD demanda maior consumo de combustível, porém reflete na maior produtividade. Para os mecanismos associados à semeadora, a HS propicia o maior desenvolvimento radicular das plantas e produtividade de grãos. Por outro lado, o DD e o DT possuem a maior capacidade operacional e menor consumo de combustível, porém, reflete em menor produtividade de grãos. RESUMO estabelecimento soja operações 6x2. 6x2 x . (6x2) eles A1 (A1 SSPSdisco SSPS +disco disco (DD) A2 (A2 (DT) A3 (A3 SSPShaste haste (HS) A4 (A4 aradora+DD aradoraDD aradora A5 (A5 escarificadoDD escarificado A6 (A6 subsoladoDD subsolado subsolado+DD 5 9 respectivamente safra elas B1 (B1 660 B2 (B2 Valente estudados escarificaçãoDD escarificação combustível lado 6x (6x2 (A (DD (DT (HS (B 66 (6x 6

ABSTRACT: The present study assessed soil preparation in terms of the advantages it provides in lowering the physical obstacles and their influence on soybean cultivation, with reference to its establishment, development and yield, apart from quantification of the energy demand for tractor performance. The experiments were performed in the field adopting the randomized block design with a two-factor scheme (6x2). Factor A included a variety of soil preparations performed during the off-season of the soybean crop. Sowing was accomplished using the same fertilizer deposition mechanism only, and the areas having no soil preparation done were sown using various other fertilizer deposition mechanisms from the seeder, namely: (A1) sowing without soil preparation (SSPS)+double disc in the seeder (DD); (A2) SSPS+turbo disc (DT); (A3) SSPS+furrowing rod (HS); (A4) plow harrow+DD; (A5) scarified+DD and (A6) subsoiled+DD. Soil preparations before sowing were done on days 52 and 98 days, respectively, during the first and second harvests. Factor B included two soybean cultivars, namely: (B1) Nidera 6601 and (B2) Brasmax Valente. No interaction was observed between the factors investigated. While the scarification+DD showed the need for higher fuel consumption, the results were increased productivity. For the seeder-linked mechanisms, the HS gives more extensive root development of the plants and grain yield. On the contrary, while DD and DT show the combination of the highest operational capacity and lower fuel usage, this is related to lower grain yield. ABSTRACT cultivation establishment yield performance twofactor factor 6x2. 6x2 x . (6x2) offseason off season crop only namely A1 (A1 SSPS+double SSPSdouble SSPS +double double (DD) A2 (A2 SSPSturbo turbo (DT) A3 (A3 SSPSfurrowing furrowing (HS) A4 (A4 harrow+DD harrowDD harrow A5 (A5 scarifiedDD scarified A6 (A6 subsoiledDD subsoiled subsoiled+DD 5 9 respectively harvests cultivars B1 (B1 660 B2 (B2 Valente investigated scarificationDD scarification consumption productivity seederlinked linked contrary usage 6x (6x2 (A (DD (DT (HS (B 66 (6x 6

ABSTRACT Introduction: CIGB-258 is a peptide, whose mechanism of action has been associated with the inhibition of inflammation. This paper aims to demonstrate that CIGB-258 reduces hyperinflammation in COVID-19 patients. Methods: Pharmacokinetic and biodistribution profiles of the peptide labeled with iodine 125 [125I] were studied in Lewis rats. Thirteen critical COVID-19 patients and nine severe ones were included and treated, according to the protocol established (RPCEC00000313). Serum samples were obtained before and after treatment with CIGB-258, for the determination of biomarkers of inflammation. Results: Maximum concentration of peptide in blood from rats was at 0,5 to 1 h; and the half-life (t½) was calculated to be 6,3 to 6,9 hours. 48 h after the treatment with CIGB-258, clinical, radiological, and ventilation improvement was observed in all patients. C-reactive protein (CRP) levels significantly decreased after 72 h. CRP levels were inversely associated with oxygen uptake efficiency in the mechanical ventilation cohort in critical patients. Laboratory tests associated with hyperinflammation included white blood cell count with differential, ferritin, lactate dehydrogenase and calprotectin, which were gradually normalized. CIGB-258 led to a significant reduction of IL-6, TNF α and IL-10. Conclusion: CIGB-258 induced a clinical and radiological improvement in the patients, according with its pharmacokinetic and biodistribution profile. This improvement was associated with a decrease in biomarkers of systemic inflammation.

RESUMEN Introducción: El CIGB-258 es un péptido, cuyo mecanismo de acción se ha asociado con la inhibición de la inflamación. El presente trabajo tiene como objetivo demostrar que el CIGB-258 reduce la hiperinflamación en los pacientes con COVID-19. Métodos. Se estudió el perfil de farmacocinética y biodistribucion del péptido marcado con yodo 125 [125I], en ratas Lewis. Se analizaron 13 pacientes críticos y 9 pacientes graves con COVID-19 de acuerdo al protocolo establecido (RPCEC00000313). Se obtuvieron muestras de suero antes y después del tratamiento con el CIGB-258, para la determinación de los biomarcadores de la inflamación. Resultados: El péptido alcanzó la máxima concentración en sangre a la media hora y su aclaramiento ocurrió aproximadamente en 6 h. Después de 48 h de tratamiento con el CIGB-258, hubo una mejoría clínica, radiológica y ventilatoria (P/F) en los pacientes. La Proteína C Reactiva (PCR) disminuyó significativamente en los pacientes, a partir de las 72 h de tratamiento. Hubo una correlación inversamente significativa entre P/F y la PCR en los pacientes críticos. Otros biomarcadores de la inflamación como: ferritina, lactado deshirogenasa y calprotectina disminuyeron significativamente. La terapia con el CIGB-258 redujo el cociente neutrófilos/linfocitos a valores normales. Las interleucinas (IL)-6, IL-10 y el TNF-α disminuyeron significativamente a las 96 h del tratamiento. Conclusiones: El CIGB-258 indujo una mejoría clínica y radiológica en los pacientes, en correspondencia con su perfil de farmacocinética y biodistribución. Dicha mejoría estuvo asociada con la disminución de biomarcadores de la inflamación sistémica.

ABSTRACT Irrigated rice cultivation is an important source of greenhouse gas emissions. Among the main greenhouse gases, there are carbon dioxide, methane, and nitrous oxide, with the emission of each gas varying according to the management of the crop, cultivar and irrigation management. In this context, the present study aimed to quantify the partial global warming potential (pGWP) measured by CH4 and N2O emissions in conventional and hybrid cultivars under two irrigation management, as well as the relation with grain yield (pGWP/Y). For this, a field experiment was conducted during the 2016/17 and 2017/18 crop seasons, with an experimental design of randomized blocks in a factorial arrangement (2×4), with four replications using water and rice cultivars. The water was managed through permanent and intermittent irrigation, with one conventional cultivar (IRGA 424 RI) and three hybrid cultivars (XP 113, Titan CL and Lexus CL). The pGWP can be reduced by up to 18% depending on the cultivar used and 11.8% through the adoption of intermittent irrigation management. More than 90% of the pGWP is due to methane emission, and the management actions of the rice crop should be directed towards the mitigation of this gas. In relation to the pGWP/Y index, the cultivar XP 113 had presented the best results.

ABSTRACT A few studies have carried out the taxonomic and molecular characterization of sylvatic mosquito species in Latin America, where some species have been incriminated as vectors for arboviruses and parasites transmission. The present study reports the molecular characterization of mosquito species in the Sierra Nevada de Santa Marta, a natural ecosystem in the Northern coast of Colombia. Manual capture methods were used to collect mosquitoes, and the specimens were identified via classical taxonomy. The COI marker was used for species confirmation, and phylogenetic analysis was performed using the neighbor-joining method, with the Kimura-2-Parameters model. Aedes serratus , Psorophora ferox , Johnbelkinia ulopus , Sabethes chloropterus , Sabethes cyaneus , Wyeomyia aporonoma , Wyeomyia pseudopecten , Wyeomyia ulocoma and Wyeomyia luteoventralis were identified. We assessed the genetic variability of mosquitoes in this area and phylogenetic reconstructions allowed the identification at the species level. Classical and molecular taxonomy demonstrated to be useful and complementary when morphological characteristics are not well preserved, or the taxonomic group is not represented in public molecular databases.

Resumo Antecedentes: A determinação da suplementação de aminoácidos em frangos de corte baseados somente no desempenho produtivo nem sempre reflete a rentabilidade máxima. Objetivo: Estimar os níveis ótimos de treonina (Thr) e aminoácidos sulfurados (SAA) em dietas para frangos de corte com base em uma análise econômica. Métodos: Foram realizados dois ensaios dose-resposta, divididos em três fases cada: inicial (1-14 dias), crescimento (15-28 dias) e final (29-42 dias). Quinhentos e sessenta frangos de corte machos Cobb 500® foram distribuídos aleatoriamente em sete tratamentos, representados por níveis crescentes de aminoácidos (SAA ou Thr), com quatro repetições de 20 aves cada. O ganho de peso (BWG) e o consumo de ração (FI) foram utilizados para ajustar um modelo segmentado. A receita bruta (GI), os custos totais de alimentação (TFC) e a margem bruta (GM) foram calculados com base nos custos locais. Resultados: Os níveis dos aminoácidos influenciaram as respostas de BWG e FI para todas as fases avaliadas. A estimativa para máximo lucro com base em GI e TFC para os ensaios com SAA foram 223, 504 e 975 mg/ave/d; para Thr foram 236, 696 e 1,042 mg/ave/d para as fases inicial, crescimento e final, respectivamente. Conclusão: A variação dos preços dos AA teve pouca influência sobre a ingestão econômica dos aminoácidos sulfurados e da Thr. Apesar do dinamismo de mercado, a abordagem econômica apresentada neste estudo demonstra ser uma ferramenta útil para a escolha do nível de inclusão ideal do aminoácido na ração.

Abstract Background: The determination of amino acid supplements for broiler chicken requirements based on performance does not always reflect maximum profitability. Objective: To estimate the optimal levels of digestible threonine (Thr) and sulfur amino acids (SAA) in diets for broilers based on an economic analysis. Methods: Two dose-response assays were conducted, and each assay was divided into three phases: initial (1-14 days), grower (15-28 days), and finisher (29-42 days). Five hundred and sixty male Cobb 500® broilers were randomly distributed to seven treatments with increasing levels of the amino acid (SAA or Thr), with four replicates and 20 birds each. Bodyweight gain (BWG) and feed intake (FI) were used to fit a segmented model. Gross income (GI), total feed costs (TFC) and gross margin (GM) were calculated based on local values. Results: Increasing levels of amino acid elicited a response in BWG and FI for all evaluated phases. The estimates for maximum profit based on GI and TFC were 223, 504, and 975 mg SAA/bird/d, and 236, 696, and 1,042 mg Thr/bird/d in starter, grower and finisher phases, respectively. Conclusion: Varying the AA prices affected only slightly the economic optimal intake of Thr and sulfur amino acids. Despite market fluctuations, the economic approach presented in this study demonstrates to be a helpful tool to choose the ideal inclusion level of amino acids in the feed.

Resumen Antecedentes: La determinación de la suplementación de aminoácidos en las dietas de pollos de engorde, basados solamente en el desempeño productivo no siempre refleja la máxima rentabilidad. Objetivo: Estimar los niveles óptimos de treonina (Thr) y aminoácidos azufrados (SAA) en dietas para pollos de engorde basados en un análisis económico. Métodos: Se realizaron dos ensayos tipo dosis-respuesta divididos en tres fases cada uno: inicio (1-14 días), crecimiento (15-28 días) y finalización (29-42 días). Quinientos sesenta pollos de engorde machos Cobb 500® se distribuyeron aleatoriamente en siete tratamientos con niveles crecientes de aminoácidos (SAA o Thr) y cuatro repeticiones de 20 aves cada uno. La ganancia de peso (BWG) y el consumo de alimento (FI) fueron utilizados para ajustar un modelo segmentado. El ingreso bruto (GI), costo total de la ración (TFC) y el margen bruto (GM) se calcularon tomando como referencia valores locales. Resultados: Los niveles crecientes de aminoácidos influyeron en la respuesta de BWG y FI en todas las fases evaluadas. Los estimados para maximizar la rentabilidad según GI y TFC fueron 223, 504 y 975 mg SAA/ave/día, y 236, 696 y 1,042 mg Thr/ave/día para las fases de inicio, crecimiento y finalización, respectivamente. Conclusión: La variación de los precios de los AA tuvo solo un ligero efecto sobre el consumo óptimo de Thr y aminoácidos azufrados. A pesar de las fluctuaciones del mercado, el enfoque económico aquí expuesto demuestra ser una herramienta útil para la elección del nivel ideal de inclusión de aminoácidos en la formulación.

Abstract The trial was conducted to evaluate the supplementation of E. coli phytase on performance, weight and ash of bones, as well as to determine the bioavailability of P and cost/benefit of its use in diets. A total 1,890 Cobb male day old chicks were assigned to six treatments and seven replicates with 45 birds each, distributed in a completely randomized design. The treatments were: Positive Control; Negative Control (NC1) - reduction of 0.06% avP; Negative Control 2 (NC2) - reduction of 0.12% avP; NC2 + Phytase (120 OTU); NC2 + Phytase (180 OTU); NC2 + Phytase (240 OTU), being 1 OTU equivalent to approximately 2 FTU. With different phytase inclusions, it was possible to verify a gradual increase on body weight gain, feed intake, feed conversion ratio, viability and even the bone characteristics of broilers fed diets containing reduction of P. The closest levels to the highest studied (240 OTU) showed the best results. The replacement of dicalcium phosphate by phytase supplementation is economically viable when the cost per OTU does not exceed US$ 1.4 × 10-5, US$1.2 × 10-5 and US$ 1.0 × 10-5 for the concentrations of 120, 180 and 240 OTU, respectively.

ABSTRACT. This study aimed to evaluate the productive characteristics, gas exchange and water use efficiency of the banana 'Prata-Anã' clone Gorutuba under different irrigation intervals associated with different emitter heights. Therefore, a field experiment was conducted in a 2 x 4 factorial scheme: two irrigation intervals (daily and every two days) and four emitter heights (50, 70, 90, and 110 cm) in a completely randomized design with four replicates. The irrigation depths applied by the microsprinkler irrigation system were calculated as a function of crop evapotranspiration. The gas exchanges were evaluated during the period of greatest climatic stress, and the productive characteristics were evaluated at harvest. The economic water use efficiency was determined indirectly by considering the production divided by the applied irrigation depth, which was the same in all the treatments. The instantaneous water use efficiency was estimated with an infrared gas analyzer in the critical climatic period. There was no interaction between the irrigation intervals and emitter heights. The two-day irrigation interval resulted in lower values of leaf temperature and photosynthetically active radiation incident on the leaves, resulting in a higher fruit weight and, consequently, higher yields and a higher water use efficiency. The highest fruit weights were obtained at heights of 70 and 90 cm.

RESUMO A doença de Parkinson figura como a segunda doença neurodegenerativa mais comum. Sua prevalência é estimada de 41 por 100.000 pessoas entre 40 e 49 anos a 1.900 por 100.000 pessoas com 80 anos ou mais. Baseando-se na essencialidade de averiguar os dispositivos vestíveis que possuem evidências clínicas literárias e com o objetivo de analisar as informações reveladas por tais tecnologias, temos a construção deste artigo científico de revisão integrativa. Trata-se de uma revisão integrativa que tem como principal objetivo realizar um sumário do estado da arte de dispositivos vestíveis utilizados em pacientes com doença de Parkinson. Após realizada a revisão, obtiveram-se oito artigos. Pode-se observar que dos artigos selecionados, apenas três não eram revisões sistemáticas, sendo um deles uma série de casos e outros dois, estudos longitudinais prospectivos. A utilização dessas tecnologias possui um campo muito rico para atuar, contudo ainda são necessárias pesquisas para que tais avaliações sejam fidedignas e cruciais para o bem-estar desses pacientes.

SUMMARY Parkinson's disease is the second most common neurodegenerative disease, with an estimated prevalence of 41/100,000 individuals affected aged between 40 and 49 years old and 1,900/100,000 aged 80 and over. Based on the essentiality of ascertaining which wearable devices have clinical literary evidence and with the purpose of analyzing the information revealed by such technologies, we conducted this scientific article of integrative review. It is an integrative review, whose main objective is to carry out a summary of the state of the art of wearable devices used in patients with Parkinson's disease. After the review, we retrieved 8 papers. Of the selected articles, only 3 were not systematic reviews; one was a series of cases and two prospective longitudinal studies. These technologies have a very rich field of application; however, research is still necessary to make such evaluations reliable and crucial to the well-being of these patients.

Resumo Objetivo: O objetivo do presente estudo foi desenvolver uma metodologia que aproxime o discente do conteúdo abordado nas aulas de anatomia do globo ocular. Métodos: Foi realizada uma incisão circular na lâmina orbital do osso frontal de um cadáver humano de uma instituição em saúde e, para acessar as estruturas orbitárias, foram dissecadas as estruturas da área criando uma via para a injeção de uma solução de borracha de silicone branca entre o cristalino e a retina com posterior enucleação e dissecação final. Resultados: O emprego da técnica permitiu que os discentes do curso construíssem o conhecimento tátil do órgão em questão e transformando o saber teórico em prático, reconhecendo músculos, funcionalidade, vasos sanguíneos e estruturas oculares durante o procedimento de dissecação. Conclusão: A metodologia empregada no presente estudo é uma opção viável para o ensino da anatomia do olho.

Abstract Objective: The objective of the present study was to develop a methodology that approximates the student of the content addressed in the classes of anatomy of the eyeball. Methods: A circular incision was made in the orbital blade of the frontal bone of a human cadaver of a health institution and, to access the orbital structures, the area structures were dissected creating a pathway for the injection of a solution of white silicone rubber between the lens and the retina with subsequent enucleation and final dissection. Results: The use of the technique allowed the students of the course to construct the tactile knowledge of the organ in question and transform the theoretical knowledge into practice, recognizing muscles, functionality, blood vessels and ocular structures during the dissection procedure. Conclusion: The methodology used in the present study is a viable option for teaching the anatomy of the eye.

RESUMO O fungo Ceratocystis cacaofunesta é um dos principais problemas na cultura do cacaueiro no Brasil. Para o cacaueiro há poucas alternativas para o controle da doença, sendo que a indução de resistência vem sendo testada como uma possibilidade de controle. Neste trabalho foram utilizados três indutores de resistências em três concentrações diferentes visando a indução de resistência do cacaueiro atacado por Ceratocystis sendo elas: glicose (0,1M, 0,5M e 1M), sacarose (0,1M, 0,5M, 1M) e acibenzolar-s-metílico (1ppm, 100ppm e 1000ppm). Além disso, amostras das plantas tratadas foram coletadas e analisadas para verificar a presença de grãos de amido. O único tratamento que não apresentou nenhuma morte de planta foi o acibenzolar-s-metílico a 1 ppm. Foi observado grãos de amido em todas as plantas tratadas, porém em quantidades diferentes. São necessários estudos mais detalhados para confirmar a efetividade do produto na indução de resistência de plantas de cacaueiro ao fungo Ceratocistys.

ABSTRACT The fungus Ceratocystis cacaofunesta is one of the main problems in cacao culture in Brazil. For cocoa, there are few alternatives to control the disease, and induction of resistance has been tested as a possibility of control. In this study, three resistance inducers were used at three different concentrations with the aim of inducing resistance in the cacao tree attacked by Ceratocystis: glucose (0.1M, 0.5M and 1M), sucrose (0.1M, 0.5M, 1M) and acibenzolar-Î2-methyl (1ppm, 100ppm and 1000ppm). In addition, samples were collected from the treated plants and analyzed for the presence of starch grains. The only treatment that did not show any plant death was acibenzolar-s-methyl at a concentration of 1 ppm. Starch grains were observed in all treated plants, but in different amounts. More detailed studies are needed to confirm the effectiveness of the product in inducing resistance of cacao plants to the fungus Ceratocistys.

Resumo: O objetivo deste trabalho foi avaliar os efeitos da adubação com nitrogênio em cobertura e silicatos, bem como da utilização de fungicidas, sobre a ocorrência de brusone nas panículas, a renda do benefício e os grãos inteiros, vítreos e gessados, em cultivar de arroz irrigado por inundação sensível à doença. Foram conduzidos dois experimentos em delineamento de blocos ao acaso, em arranjo fatorial 4×4×2, com quatro repetições: no experimento 1, quatro doses de nitrogênio × quatro doses de silicato de cálcio e magnésio via solo × com e sem uso de fungicidas; e, no experimento 2, quatro doses de nitrogênio × quatro doses de silicato de potássio via foliar × com e sem fungicidas. Nas doses acima de 60 kg ha-1 de nitrogênio sem fungicidas, houve aumento da severidade de brusone nas panículas, redução do percentual de grãos inteiros e vítreos, e aumento de grãos gessados e área gessada. Os maiores efeitos dos silicatos ocorreram sem aplicações de fungicidas. O uso de fungicidas reduziu a severidade de brusone nas panículas. A renda do benefício oscilou entre 60 e 70%, em ambos os experimentos. O controle da brusone com fungicidas mantém elevadas a qualidade de grãos do arroz, a renda do benefício e as percentagens de grãos inteiros e vítreos.

Abstract: The objective of this work was to evaluate the effects of fertilization with nitrogen topdressing and silicates, as well as of the use of fungicides, on the occurrence of rice blast on panicles, milling yield, and whole grains, vitreous grains, and chalky kernels in a flood-irrigated rice cultivar sensitive to the disease. Two experiments were conducted in a randomized complete block design, in a 4×4×2 factorial arrangement, with four replicates: in experiment 1, four doses of nitrogen × four doses of calcium and magnesium silicate on soil × with and without fungicides; and, in experiment 2, four doses of nitrogen × four doses of potassium silicate applied on leaves x with and without fungicides. At the doses above 60 kg ha-1 nitrogen without fungicides, there was an increase of rice blast severity on panicles, a decrease in the percentage of whole and vitreous grains, and an increase in chalky kernels and chalky area. The greatest effects of silicates occurred without fungicides. Fungicide use reduced the severity of rice blast on panicles. Milling yield ranged from 60 to 70% in both experiments. The control of rice blast with fungicides maintains high rice grain quality, milling yield, and percentages of whole and vitreous grains.

Resumo Objetivou-se avaliar a prevalência e o padrão de distribuição da má oclusão em pré-escolares brasileiros e sua associação com macrorregião, local de moradia, sexo e raça autodeclarada. Foram analisados dados de 6.855 crianças de 5 anos participantes do SB Brasil 2010. No levantamento, a má oclusão foi diagnosticada segundo o Índice de Foster e Hamilton. Conduziu-se análises descritivas, bivariadas e múltiplas (RP/IC95%). Identificou-se que 63,2% das crianças possuíam ao menos um dos problemas oclusais avaliados: chave de caninos (22,9%), sobressaliência (32,9%), sobremordida (34,6%), e mordida cruzada posterior (18,7%) e, portanto, foram considerados com má oclusão. Maior chance da presença de má oclusão foi identificada entre os residentes das regiões Centro-Oeste (1,08/IC95%-1,01-1,15), Nordeste (1,21/IC95%-1,14-1,28), Sudeste (1,27/IC95%-1,20-1,34) e Sul (1,34/IC95%-1,26-1,42), quando comparados aos residentes na região Norte. Foi maior também entre as crianças do sexo feminino (1,06/IC95%-1,02-1,09). Identificou-se elevada prevalência de má oclusão em pré-escolares brasileiros, sendo esta associada ao sexo e à macrorregião de moradia. Tais achados podem contribuir na ampliação de políticas públicas e no acesso ao tratamento para esta população.

Abstract This study aimed to evaluate the prevalence and distribution profile of malocclusion in Brazilian preschoolers and its association with macro-region, housing, gender, and self-reported race. In total, 6,855 children aged five years participating in the National Oral Health Survey (called SB Brasil 2010) were analyzed. Malocclusion was diagnosed according to the Foster and Hamilton index. We conducted descriptive, bivariate and multiple regression analyses (PR/CI95%). We identified that 63.2% of children had at least one of the occlusal problems evaluated: canines’ key (22.9%), overjet (32.9%), overbite (34.6%), and posterior crossbite (18.7%) and, thus, were considered with malocclusion. Higher probability of the presence of malocclusion was identified among the residents of the Midwest (1.08/95%CI 1.01-1.15), Northeast (1.21/95%CI 1.14-1.28), Southeast (1.27/95%CI 1.20-1.34) and South (1.34/95%CI 1.26-1.42) regions when compared to residents in the North. It was also higher among female children (1.06/95% CI 1.02-1.09). No associations were identified concerning race and location of the municipality (capital/no capital). A high prevalence of malocclusion was identified in Brazilian preschoolers, and it was associated with gender and the macro-region. These findings may contribute to expanded public policies and greater access to treatment for this population.

Resumo Estudo transversal e analítico para caracterizar a maloclusão em crianças brasileiras de 12 anos e identificar os aspectos sociodemográficos associados, utilizando dados do SB Brasil 2010. Foram incluídas 5539 crianças dentre as quais 41% possuíam algum grau de maloclusão, de acordo com o índice Dental Aesthetic Index (DAI). Conduziu-se análises descritivas, bivariadas e múltiplas por regressão logística multinomial. A maloclusão definida foi maior entre os que avaliaram sua saúde bucal como nem satisfeito/nem insatisfeito (OR 1,24; IC 95%; 1,03-1,50) e insatisfeito (OR 1,76; IC 95%; 1,50-2,08). A maloclusão grave foi maior entre crianças do Sudeste (OR 1,44; IC 95%; 1,06-1,96) e Sul (OR 1,52; IC 95%; 1,05-2,19), sexo masculino (OR 1,24; IC 95%; 1,03-1,48), raça negro/pardo (OR 1,39; IC 95%; 1,14-1,69) e que avaliaram sua saúde bucal como nem satisfeito/nem insatisfeito (OR 1,79; IC 95%; 1,41-2,26) e insatisfeito (OR 2,20; IC 95%; 1,77-2,72). O nível muito grave foi maior entre os residentes de capitais (OR 1,36; IC 95%; 1,07-1,71) e que avaliaram sua saúde bucal como nem satisfeito/nem insatisfeito (OR 1,58; IC 95%; 1,22-2,05) e insatisfeito (OR 2,44; IC 95%; 1,96-3,03). A prevalência da maloclusão é alta entre crianças brasileiras, sendo suas diferentes gravidades associadas a aspectos sociodemográficos.

Abstract The scope of this study was to characterize malocclusion in 12-year-old Brazilian children and identify associated socio-demographic aspects. It is a cross-sectional and analytical study based on an Oral Health Survey (SB Brasil 2010). A sample of 5,539 was included, among which 41% had some degree of malocclusion according to the Dental Aesthetic Index (DAI). Descriptive, bivariate and multiple multinomial logistic regression analyses were conducted. Defined malocclusion was greater among those who rated their oral health as neither satisfied/nor dissatisfied (OR 1.24; CI95%1.03-1.50) and dissatisfied (OR 1.76; CI95%1.50-2.08). Severe malocclusion was greater among children in the Southeast (OR 1.44; CI95%1.06-1.96) and South (OR 1.52; CI95%1.05-2.19), male (OR 1.24; CI95%1.03-1.48), black/brown (OR 1.39; CI95%1.14-1.69) who rated their oral health as neither satisfied/nor dissatisfied (OR 1.79; CI95%1.41-2.26) and dissatisfied (OR 2.20; CI95%1.77-2.72). Very severe malocclusion was higher among residents of capitals (OR 1.36; CI95%1.07-1.71) who evaluated their oral health as neither satisfied/nor dissatisfied (OR 1.58; CI95%1.22-2.05) and dissatisfied (OR 2.44; CI95%1.96-3.03). The prevalence of malocclusion is high among Brazilian children, the severity being associated with socio-demographic aspects.

Resumo Estudo transversal e analítico para caracterizar a maloclusão em crianças brasileiras de 12 anos e identificar os aspectos sociodemográficos associados, utilizando dados do SB Brasil 2010. Foram incluídas 5539 crianças dentre as quais 41% possuíam algum grau de maloclusão, de acordo com o índice Dental Aesthetic Index (DAI). Conduziu-se análises descritivas, bivariadas e múltiplas por regressão logística multinomial. A maloclusão definida foi maior entre os que avaliaram sua saúde bucal como nem satisfeito/nem insatisfeito (OR 1,24; IC 95%; 1,03-1,50) e insatisfeito (OR 1,76; IC 95%; 1,50-2,08). A maloclusão grave foi maior entre crianças do Sudeste (OR 1,44; IC 95%; 1,06-1,96) e Sul (OR 1,52; IC 95%; 1,05-2,19), sexo masculino (OR 1,24; IC 95%; 1,03-1,48), raça negro/pardo (OR 1,39; IC 95%; 1,14-1,69) e que avaliaram sua saúde bucal como nem satisfeito/nem insatisfeito (OR 1,79; IC 95%; 1,41-2,26) e insatisfeito (OR 2,20; IC 95%; 1,77-2,72). O nível muito grave foi maior entre os residentes de capitais (OR 1,36; IC 95%; 1,07-1,71) e que avaliaram sua saúde bucal como nem satisfeito/nem insatisfeito (OR 1,58; IC 95%; 1,22-2,05) e insatisfeito (OR 2,44; IC 95%; 1,96-3,03). A prevalência da maloclusão é alta entre crianças brasileiras, sendo suas diferentes gravidades associadas a aspectos sociodemográficos.

Abstract The scope of this study was to characterize malocclusion in 12-year-old Brazilian children and identify associated socio-demographic aspects. It is a cross-sectional and analytical study based on an Oral Health Survey (SB Brasil 2010). A sample of 5,539 was included, among which 41% had some degree of malocclusion according to the Dental Aesthetic Index (DAI). Descriptive, bivariate and multiple multinomial logistic regression analyses were conducted. Defined malocclusion was greater among those who rated their oral health as neither satisfied/nor dissatisfied (OR 1.24; CI95%1.03-1.50) and dissatisfied (OR 1.76; CI95%1.50-2.08). Severe malocclusion was greater among children in the Southeast (OR 1.44; CI95%1.06-1.96) and South (OR 1.52; CI95%1.05-2.19), male (OR 1.24; CI95%1.03-1.48), black/brown (OR 1.39; CI95%1.14-1.69) who rated their oral health as neither satisfied/nor dissatisfied (OR 1.79; CI95%1.41-2.26) and dissatisfied (OR 2.20; CI95%1.77-2.72). Very severe malocclusion was higher among residents of capitals (OR 1.36; CI95%1.07-1.71) who evaluated their oral health as neither satisfied/nor dissatisfied (OR 1.58; CI95%1.22-2.05) and dissatisfied (OR 2.44; CI95%1.96-3.03). The prevalence of malocclusion is high among Brazilian children, the severity being associated with socio-demographic aspects.

Resumo Objetivou-se avaliar a prevalência e o padrão de distribuição da má oclusão em pré-escolares brasileiros e sua associação com macrorregião, local de moradia, sexo e raça autodeclarada. Foram analisados dados de 6.855 crianças de 5 anos participantes do SB Brasil 2010. No levantamento, a má oclusão foi diagnosticada segundo o Índice de Foster e Hamilton. Conduziu-se análises descritivas, bivariadas e múltiplas (RP/IC95%). Identificou-se que 63,2% das crianças possuíam ao menos um dos problemas oclusais avaliados: chave de caninos (22,9%), sobressaliência (32,9%), sobremordida (34,6%), e mordida cruzada posterior (18,7%) e, portanto, foram considerados com má oclusão. Maior chance da presença de má oclusão foi identificada entre os residentes das regiões Centro-Oeste (1,08/IC95%-1,01-1,15), Nordeste (1,21/IC95%-1,14-1,28), Sudeste (1,27/IC95%-1,20-1,34) e Sul (1,34/IC95%-1,26-1,42), quando comparados aos residentes na região Norte. Foi maior também entre as crianças do sexo feminino (1,06/IC95%-1,02-1,09). Identificou-se elevada prevalência de má oclusão em pré-escolares brasileiros, sendo esta associada ao sexo e à macrorregião de moradia. Tais achados podem contribuir na ampliação de políticas públicas e no acesso ao tratamento para esta população.

Abstract This study aimed to evaluate the prevalence and distribution profile of malocclusion in Brazilian preschoolers and its association with macro-region, housing, gender, and self-reported race. In total, 6,855 children aged five years participating in the National Oral Health Survey (called SB Brasil 2010) were analyzed. Malocclusion was diagnosed according to the Foster and Hamilton index. We conducted descriptive, bivariate and multiple regression analyses (PR/CI95%). We identified that 63.2% of children had at least one of the occlusal problems evaluated: canines’ key (22.9%), overjet (32.9%), overbite (34.6%), and posterior crossbite (18.7%) and, thus, were considered with malocclusion. Higher probability of the presence of malocclusion was identified among the residents of the Midwest (1.08/95%CI 1.01-1.15), Northeast (1.21/95%CI 1.14-1.28), Southeast (1.27/95%CI 1.20-1.34) and South (1.34/95%CI 1.26-1.42) regions when compared to residents in the North. It was also higher among female children (1.06/95% CI 1.02-1.09). No associations were identified concerning race and location of the municipality (capital/no capital). A high prevalence of malocclusion was identified in Brazilian preschoolers, and it was associated with gender and the macro-region. These findings may contribute to expanded public policies and greater access to treatment for this population.