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ABSTRACT Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses within a 28-day interval. IC received two additional BNT162b2 doses and H received a third BNT162b2 dose (booster). Blood samples were collected at baseline, 28 days after each dose, pre-booster and at the trial end. We used three serological tests to detect antibodies to SARS-CoV-2 nucleocapsid (N), trimeric spike (S), and receptor binding domain (RBD). Outcomes included seroconversion rates (SCR), geometric mean titers (GMT) and GMT ratio (GMTR). A total of 241 IC and 100 H adults participated in the study. After two CoronaVac doses, IC had lower SCR than H: anti-N, 33.3% vs 79%; anti-S, 33.8% vs 86%, and anti-RBD, 48.5% vs 85%, respectively. IC also showed lower GMT than H: anti-N, 2.3 vs 15.1; anti-S, 58.8 vs 213.2 BAU/mL; and anti-RBD, 22.4 vs 168.0 U/mL, respectively. After the 3rd and 4th BNT162b2 doses, IC had significant anti-S and anti-RBD seroconversion, but still lower than H after the 3rd dose. After boosting, GMT increased in IC, but remained lower than in the H group. CoronaVac two-dose schedule immunogenicity was lower in IC than in H. BNT162b2 heterologous booster enhanced immune response in both groups. COVID19 COVID 19 COVID-1 scarce BNTb BNT b BNT162b (IC (H SOT, SOT , (SOT) cancer comparison 28day day interval booster. . (booster) baseline 2 prebooster pre end SARSCoV2 SARSCoV SARS CoV SARS-CoV- N, N (N) S, S (S) RBD. RBD (RBD) SCR, (SCR) (GMT GMTR. GMTR (GMTR) 24 10 study antiN, antiN anti anti-N 333 33 3 33.3 79% 79 antiS, antiS 338 8 33.8 86 86% antiRBD, antiRBD RBD, 485 48 5 48.5 85 85% respectively 23 2. 15.1 151 15 1 588 58 58. 2132 213 213. BAU/mL BAUmL BAU mL 224 22 4 22. 1680 168 0 168. UmL U U/mL rd th boosting twodose groups COVID1 COVID- (SOT (booster SARS-CoV (N (S (RBD (SCR (GMTR 33. 7 48. 15. 21 16

https://doi.org/10.1590/s1678-9946202466024

Posicionamento Brasileiro sobre Síndrome da Quilomicronemia Familiar – 2023 202 20 2
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Izar, Maria Cristina de Oliveira

; Santos Filho, Raul Dias dos

; Assad, Marcelo Heitor Vieira

; Chagas, Antonio Carlos Palandri

; Toledo Júnior, Alceu de Oliveira

; Nogueira, Ana Cláudia Cavalcante

; Souto, Ana Cristina Carneiro Fernandes

; Lottenberg, Ana Maria

; Chacra, Ana Paula Marte

; Ferreira, Carlos Eduardo dos Santos

; Lourenço, Charles Marques

; Valerio, Cynthia Melissa

; Cintra, Dennys Esper

; Fonseca, Francisco Antonio Helfenstein

; Campana, Gustavo Aguiar

; Bianco, Henrique Tria

; Lima, Josivan Gomes de

; Castelo, Maria Helane Costa Gurgel

; Scartezini, Marileia

; Moretti, Miguel Antonio

; Barreto, Natasha Slhessarenko Fraife

; Maia, Rayana Elias

; Montenegro Junior, Renan Magalhães

; Alves, Renato Jorge

; Figueiredo, Roberta Marcondes Machado

; Fock, Rodrigo Ambrosio

; Martinez, Tânia Leme da Rocha

; Giraldez, Viviane Zorzanelli Rocha

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 4 elocation e20230203

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230203

Clinical Impact of the Line Probe Assay and Xpert® MTB/RIF Assay in the Presumptive Diagnosis of Drug-Resistant Tuberculosis in Brazil: A Pragmatic Clinical Trial
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Kritski, Afranio

; Oliveira, Maria Martha

; Almeida, Isabela Neves de

; Ramalho, Daniela

; Andrade, Monica Kramer de Noronha

; Carvalho, Monica

; Miranda, Pryscila Fernandes Campino

; Dalcolmo, Margareth Pretti

; Braga, Jose Ueleres

; Brígido, Tania

; Mesquita, Eliene

; Dias, Claudia

; Gambirasio, Aglae

; Souza Filho, Joao Baptista

; Detjen, Anne

; Phillips, Patrick Peter John

; Langley, Ivor

; Fujiwara, Paula

; Squire, Stephen Bertel

Revista da Sociedade Brasileira de Medicina Tropical

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2022, Volume 55 elocation e0191-2021

Abstract: En | Text: En | PDF: En

ABSTRACT Background: Rapid molecular methods such as the line probe assay (LPA) and Xpert® MTB/RIF assay (Xpert) have been recommended by the World Health Organization for drug-resistant tuberculosis (DR-TB) diagnosis. We conducted an interventional trial in DR-TB reference centers in Brazil to evaluate the impact of the use of LPA and Xpert. Methods: Patients with DR-TB were eligible if their drug susceptibility testing results were available to the treating physician at the time of consultation. The standard reference MGITTM 960 was compared with Xpert (arm 1) and LPA (arm 2). Effectiveness was considered as the start of the appropriate TB regimen that matched drug susceptibility testing (DST) and the proportions of culture conversion and favorable treatment outcomes after 6 months. Results: A higher rate of empirical treatment was observed with MGIT alone than with the Xpert assay (97.0% vs. 45.0%) and LPA (98.2% vs. 67.5%). Patients started appropriate TB treatment more quickly than those in the MGIT group (median 15.0 vs. 40.5 days; p<0.01) in arm 1. Compared to the MGIT group, culture conversion after 6 months was higher for Xpert in arm 1 (90.9% vs. 79.3%, p=0.39) and LPA in arm 2 (80.0% vs. 83.0%, p=0.81). Conclusions: In the Xpert arm, there was a significant reduction in days to the start of appropriate anti-TB treatment and a trend towards greater culture conversion in the sixth month.

https://doi.org/10.1590/0037-8682-0191-2021

Development and evaluation of topical formulations that contain hydroethanolic extract from Schinus terebinthifolia against HSV-1 infection
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Nocchi, Samara Requena

; Ferreira, Lilian dos Anjos Oliveira

; Castro-Hoshino, Lidiane Vizioli de

; Truiti, Maria da Conceição Torrado

; Natali, Maria Raquel Marçal

; Mello, João Carlos Palazzo de

; Baesso, Mauro Luciano

; Dias Filho, Benedito Prado

; Nakamura, Celso Vataru

; Ueda-Nakamura, Tânia

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e18637

Abstract: En | Text: En | PDF: En

Abstract The therapeutic drugs to treat Herpes simplex virus (HSV) infections have toxic side effects and there has been an emergence of drug-resistant strains. Therefore, the search for new treatments for HSV infections is mounting. In the present study, semi-solid formulations containing a crude hydroethanolic extract (CHE) from Schinus terebinthifolia were developed. Skin irritation, cutaneous permeation, and in vivo therapeutic efficacy of the formulations were investigated. Treatment with the ointment formulations did not result in any signs of skin irritation while the emulsions increased the thickness of the epidermis in Swiss mice. The cutaneous permeation test indicated that the CHE incorporated in the formulations permeated through the skin layers and was present in the epidermis and dermis even 3 h after topical application. In vivo antiviral activity in BALB/c mice treated with the CHE ointments was better than those treated with the CHE emulsions and did not significantly differ from an acyclovir-treated group. Taken together, this suggests that the incorporation of CHE in the ointment may be a potential candidate for the alternative topical treatment of herpetic lesions.

https://doi.org/10.1590/s2175-97902020000318637

Indicadores referentes à cessação do comportamento de fumar no Brasil, Pesquisa Nacional de Saúde, edições 2013 e 2019
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Oliveira, Patrícia Pereira Vasconcelos de

; Pereira, Vinícius Oliveira de Moura

; Stopa, Sheila Rizzato

; Freitas, Paula Carvalho de

; Szklo, André Salem

; Cavalcante, Tânia Maria

; Andrade, Fabiana Martins Dias de

; Gomes, Crizian Saar

; Malta, Deborah Carvalho

Epidemiologia e Serviços de Saúde

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2022, Volume 31 N. spe1 elocation e2021388

Abstract: En Pt Es | Text: En Pt Es | PDF: En | PDF: Pt | PDF: Es

Abstract Objective: To describe the indicators of smoking cessation in 2013 and 2019 for Brazil and federative units, according to sociodemographic variables, collected in the National Health Survey (PNS). Methods: Cross-sectional, population-based and descriptive study with data from the 2013 and 2019 PNS, a household survey collected by trained interviewers. The prevalence of ex-smokers and the proportion of smokers who tried to quit smoking in the 12 months prior to the interview, and respective confidence intervals (95%CI) were calculated, according to sociodemographic variables. Additionally, the percentage variation between the years was calculated. Results: In 2013, the prevalence of ex-smokers was 17.5% (95%CI 16.9;18.0) and, in 2019, 26.6% (95%CI 26.1;27.2). In 2013, 51.1% tried to quit smoking (95%CI 49.3;52.9) and, in 2019, 46.6% (95%CI 45.0;48.3). Conclusion: It is important to strengthen and maintain strategies for coping with tobacco use in Brazil, to increase the current smoker's willingness and ability to quit smoking.

Resumo Objetivo: Descrever os indicadores de abandono do uso de tabaco, em 2013 e 2019, para o Brasil e as Unidades da Federação, segundo variáveis sociodemográficas, coletadas na Pesquisa Nacional de Saúde (PNS). Métodos: Estudo transversal, populacional e descritivo realizado com dados da PNS 2013 e 2019, uma pesquisa domiciliar coletada por entrevistadores treinados. Foram calculadas a prevalência de ex-fumantes e a proporção de fumantes que tentaram parar de fumar nos últimos 12 meses imediatamente anteriores à data da entrevista, e os respectivos intervalos de confiança (IC95%), segundo as variáveis sociodemográficas. Ademais, calculou-se a variação percentual entre os anos estudados. Resultados: Em 2013, a prevalência de ex-fumantes foi 17,5% (IC95% 16,9;18,0) e, em 2019, 26,6% (IC95% 26,1;27,2). Tentaram parar de fumar 51,1% (IC95% 49,3;52,9), em 2013, e 46,6% (IC95% 45,0;48,3) em 2019. Conclusão: É importante o fortalecimento e manutenção de estratégias para enfrentamento do uso de tabaco no país, de forma a aumentar a disposição e a capacidade do fumante atual de parar de fumar.

Resumen Objetivo: Describir los indicadores de abandono del hábito tabáquico en 2013 y 2019 para Brasil y Unidades Federadas, según variables sociodemográficas, recogidas en la Encuesta Nacional de Salud (PNS). Métodos: Estudio transversal, poblacional y descriptivo con datos de las PNS, 2013 y 2019, una encuesta de hogares recolectada por entrevistadores capacitados. Se calculó la prevalencia de exfumadores y proporción de fumadores que intentaron dejar de fumar en los últimos 12 meses y respectivos intervalos de confianza (IC95%), según variables sociodemográficas. Además, se calculó la variación porcentual entre los años. Resultados: En 2013, la prevalencia de exfumadores fue de 17,5% (IC95% 16,9;18,0), en 2019, 26,6% (IC95% 26,1;27,2). En 2013, el 51,1% intentó dejar de fumar (IC95% 49,3;52,9), y, en 2019, el 46,6% (IC95% 45,0;48,3). Conclusión: Es importante fortalecer y mantener las estrategias de afrontamiento del tabaquismo, para incrementar la disposición y capacidad del fumador actual para dejar de fumar.

https://doi.org/10.1590/ss2237-9622202200005.especial

Indicadores referentes à cessação do comportamento de fumar no Brasil, Pesquisa Nacional de Saúde, edições 2013 e 2019
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Oliveira, Patrícia Pereira Vasconcelos de

; Pereira, Vinícius Oliveira de Moura

; Stopa, Sheila Rizzato

; Freitas, Paula Carvalho de

; Szklo, André Salem

; Cavalcante, Tânia Maria

; Andrade, Fabiana Martins Dias de

; Gomes, Crizian Saar

; Malta, Deborah Carvalho

Epidemiologia e Serviços de Saúde

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2022, Volume 31 N. spe1 elocation e2021388

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/ss2237-9622202200005.especial

Trabalho e família de trabalhadoras domésticas em tempos de pandemia: uma análise interseccional
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Valeriano, Marta Maria

; Tosta, Tania Ludmila Dias

Civitas - Revista de Ciências Sociais

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dec 2021, Volume 21 N. 3 Pages 412 - 422

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: Este artigo discute a intersecção de raça, gênero e classe na produção das desigualdades vividas por trabalhadoras domésticas no Brasil e como essas desigualdades se acirram em contexto de crise pandêmica. Com base em uma análise de microdados da Pesquisa Nacional por Amostra de Domicílios (Pnad Contínua) e de entrevistas com trabalhadoras domésticas na região metropolitana de Goiânia, examinamos as desigualdades na relação trabalho e família, considerando aspectos relacionados às condições de trabalho, aos usos do tempo e aos arranjos domésticos. Os resultados indicam que a pandemia, precedida e intensificada por um duro contexto de recessão econômica e de ampliação de políticas de flexibilização dos direitos trabalhistas, acentuou desigualdades historicamente estruturantes da ocupação. Esses elementos incidem sobre o cotidiano das trabalhadoras domésticas, reorganizando os arranjos domésticos e suas vivências temporais.

Abstract: This article discusses the intersection of race, gender and class in the production of inequalities experienced by domestic workers in Brazil and how these inequalities are accentuated in the context of a pandemic crisis. Based on an analysis of the data issued by the Brazilian National Household Sample Survey (Pnad-Contínua) and on interviews with domestic workers in the metropolitan region of Goiânia, we examine the inequalities in the relationship between work and family, considering aspects related to working conditions, the use of time and domestic arrangements. The results indicate that the pandemic, preceded and intensified by a harsh context of economic recession and expansion of policies for the flexibilization of labor rights, has amplified historically structural inequalities in the occupation. These elements affect the everyday lives of domestic workers, reorganizing domestic arrangements and their temporal experiences.

Resumen: Este artículo analiza la intersección de raza, género y clase en la producción de desigualdades que experimentan las trabajadoras del hogar en Brasil y cómo estas desigualdades se agudizan en el contexto de una crisis pandémica. A partir de un análisis de microdatos de la Encuesta Nacional por Muestra de Hogares (Pnad-Contínua) y de entrevistas con trabajadoras del hogar en la región metropolitana de Goiânia, examinamos las desigualdades en la relación entre trabajo y familia, considerando aspectos relacionados con las condiciones laborales, usos del tiempo y arreglos domésticos. Los resultados indican que la pandemia, precedida e intensificada por un duro contexto de recesión económica y expansión de políticas para flexibilizar los derechos laborales, acentuó las desigualdades históricamente estructurales en la ocupación. Estos elementos afectan la vida diaria de las trabajadoras del hogar, reorganizando los arreglos domésticos y sus experiencias temporales.

https://doi.org/10.15448/1984-7289.2021.3.40571

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

Trabalho remoto docente e saúde: repercussões das novas exigências em razão da pandemia da Covid-19
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Pinho, Paloma de Sousa

; Freitas, Aline Macedo Carvalho

; Cardoso, Mariana de Castro Brandão

; Silva, Jéssica Silva da

; Reis, Lívia Ferreira

; Muniz, Caio Fellipe Dias

; Araújo, Tânia Maria de

Trabalho, Educação e Saúde

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jan 2021, Volume 19 elocation e00325157

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo O estudo objetivou descrever características do trabalho remoto, situação de saúde mental e qualidade de sono na pandemia da Covid-19 em docentes da Bahia. Foi conduzido websurvey, seguindo protocolo CHERRIES, com professoras/es de todos os níveis de ensino da rede particular do estado. Participaram 1.444 docentes, de 18 julho a 30 de julho de 2020. Predominaram mulheres (76,1%), 21-41 anos (61,6%), negras (71,9%), dez anos ou mais na profissão (56,9%). Na pandemia, 51,4% relataram alterações no contrato de trabalho e 76,8%, aumento da jornada laboral. O ambiente domiciliar e equipamentos tinham baixo nível de adequação ao trabalho remoto: espaço físico (19,6%), mobiliário (21,7%), nível de ruído (17,2%), computadores (44,5%) e internet banda larga (36,7%). Entre as mulheres, 42,3% referiram sobrecarga doméstica alta; entre os homens, 17,4%. As mulheres apresentaram situação de saúde preocupante, destacando-se crises de ansiedade (53,7%), mau humor (78,0%), transtornos mentais comuns (69,0%) e qualidade do sono ruim (84,6%). A pandemia remodelou as formas de exercer o ofício docente. O trabalho, transferido para a casa, se sobrepôs às atividades domésticas e familiares, produzindo consequências à saúde docente que, mesmo pouco conhecidas, são alarmantes. Os resultados fortalecem a necessidade de ações de enfrentamento para situações de calamidade pública, medidas de regulação do trabalho remoto e proteção à saúde docente.

Abstract The study aimed to describe characteristics of remote work, mental health status and sleep quality in the COVID-19 pandemic among teachers in Bahia, Brazil. A websurvey was conducted, following the CHERRIES protocol, with teachers from all levels of education in the state’s private network. A total of 1,444 professors participated, from June 18 to July 30, 2020. There was a predominance of women (76.1%), 21-41 years (61.6%), black (71.9%), ten years or more in the profession (56.9%). In the pandemic, 51.4% reported changes in the employment contract and 76.8%, an increase in working hours. The home environment and equipment had a low level of suitability for remote work: physical space (19.6%), furniture (21.7%), noise level (17.2%), computers (44.5%) and internet broadband (36.7%). Among women, 42.3% reported high housework burden; among men, 17.4%. The women presented a worrying health situation, highlighting anxiety crises (53.7%), bad mood (78.0%), common mental disorders (69.0%) and poor sleep quality (84.6%). The pandemic remodeled the ways of exercising the teaching profession. The work, transferred to the home, was superimposed on domestic and family activities, producing consequences for the health of teachers that, although little known, are alarming. The results strengthen the need for actions to deal with situations of public calamity, measures to regulate remote work and protect teachers’ health.

Resumen El estudio tuvo como objectivo describir las características del trabajo remoto, la situación de salud mental y la calidad del sueño en la pandemia de Covid-19 entre docentes de Bahia. Se condujo una encuesta websurvey, siguiendo el protocolo CHERRIES, con profesoras y profesores de todos los niveles educativos de la red privada del estado/departamento. Contestaron a la encuesta 1.444 docentes, del 18 de junio hasta el 30 de julio de 2020. Predominaron mujeres (76,1%), de 21-41 años de edad (61,6%), negras (71,9%), con diez años o más de profesión (56,9%). En la pandemia, el 51,4% informó cambios en los contratos de trabajo y el 76, 8%, un aumento en la jornada laboral. El ambiente domiciliario y los equipos tenían un bajo nivel de adecuación para el trabajo remoto: espacio físico (19,6%), mobiliario (21,7%), nivel de ruido (17,2%), ordenadores (44,5%) y internet banda ancha (36,7%). Entre las mujeres, el 42,3% refirió una alta sobrecarga de trabajo doméstico; entre los hombres, 17,4% lo informó. Las mujeres presentaron una situación de salud preocupante, mayormente crises de ansiedad (53,7%), mal humor (78,9%), trastornos mentales comunes (69,0%) y mala calidad del sueño (84,6%). La pandemia remodeló las formas de ejercer el oficio docente. El trabajo, transferido al hogar, se ha sobrepuesto a las actividades domésticas y de la família, produciendo consecuencias a la salud de los docentes que, aun poco conocidas, son alarmantes. Los resultados refuerzan la necesidad de acciones para el enfrentamiento de situaciones de calamidad pública, de medidas de regulación del trabajo remoto y de protección a la salud docente.

https://doi.org/10.1590/1981-7746-sol00325 1129 downloads

10.

"De mão-em-mão tramando redes e normas: a vida social das pílulas anticoncepcionais, a partir de suas bulas"
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Dias, Tania Maria

; Bonan, Claudia

; Maksud, Ivia

; Rodrigues, Andreza Pereira

Physis: Revista de Saúde Coletiva

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2021, Volume 31 N. 2 elocation e310222

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Com o objetivo de descortinar aspectos da vida social das pílulas anticoncepcionais, o artigo analisou o conteúdo de suas bulas publicados no guia de medicamentos Dicionário de Especialidades Farmacêuticas (DEF), entre 1971 e 1990. Procuramos explorar os discursos veiculados nesses dispositivos - a quem se dirigiam, o que propunham e que efeitos pretendiam - e compreender como contribuíram e o que nos revelaram sobre o seu percurso biográfico. As bulas se comportaram como importantes veículos de intercomunicação entre os atores que participaram da trajetória desses medicamentos, desde sua produção pela da indústria farmacêutica, até chegarem às suas consumidoras finais, as mulheres, passando também por médicos, enfermeiros, farmacêuticos, donos e balconistas de farmácias e transitando entre consultórios, serviços de saúde, entidades de planejamento familiar, estabelecimentos comerciais, lares e bolsas femininas. Nessa enorme cadeia de associações produzidas pelas pílulas, as bulas contribuíram para a geração de um mínimo denominador comum que permitiu a normalização e naturalização das práticas de controle da fecundidade hormonal e para a formação do mercado - não só no sentido econômico, mas em sentido sociológico, como redes de interações e trocas, onde circularam bens que agregaram a um só tempo valores econômicos, simbólicos e normativos.

Abstract In order to uncover aspects of social life of pharmaceutical pills and based on the theoretical-methodological perspective of the drugs biography, this paper analyzes the instructions of their leaflets, published in the Dictionary of Pharmaceutical Specialties (DEF), between 1971 and 1990. It seeks to explore the speeches conveyed in papers that accompanied the packaging of the "medicine pill" - to whom they were headed, what they proposed and what social effects they intended - and to understand their participation in the set of associations that allowed the stabilization of oral contraceptives in Brazil. Leaving the pharmaceutical laboratories, the patient information leaflet transited among physicians, nurses, pharmacists, owners and shopkeepers of pharmacies and women, passing from hand to hand, in offices, health services family planning entities, pharmacy counters, medical departments of companies, households and women's bag. They were the important intercommunication vehicles between these actors and in the big chain of associations produced by contraceptive pills, the patient information leaflets contributed to a minimum common denominator that allowed to return a normal and natural control practices of hormone-mediated fecundity and the formation of the fertility control pill market, where goods were giving movement to add economic, symbolic and normative values at the same time.

https://doi.org/10.1590/s0103-73312021310222 160 downloads

11.

"De mão-em-mão tramando redes e normas: a vida social das pílulas anticoncepcionais, a partir de suas bulas"
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Dias, Tania Maria

; Bonan, Claudia

; Maksud, Ivia

; Rodrigues, Andreza Pereira

Physis: Revista de Saúde Coletiva

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2021, Volume 31 N. 2 elocation e310222

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/s0103-73312021310222

12.

SARS-CoV-2 recombinant proteins stimulate distinct cellular and humoral immune response profiles in samples from COVID-19 convalescent patients
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Silva, Laís Teodoro da

; Ortega, Marina Mazzilli

; Tiyo, Bruna Tiaki

; Viana, Isabelle Freire Tabosa

; Lima, Tayná Evily de

; Tozetto-Mendoza, Tania Regina

; Oliveira, Luanda Mara da Silva

; Teixeira, Franciane Mouradian Emidio

; Lins, Roberto Dias

; Almeida, Alexandre de

; Mendes-Correa, Maria Cassia

; Duarte, Alberto Jose da Silva

; Oshiro, Telma Miyuki

Clinics

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2021, Volume 76 elocation e3548

Abstract: En | Text: En | PDF: En

OBJECTIVES: In this preliminary study we investigated cellular and humoral immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens in blood samples from 14 recovered coronavirus disease 2019 (COVID-19) patients and compared them to those in samples from 12 uninfected/unvaccinated volunteers. METHODS: Cellular immunity was assessed by intracellular detection of IFN-γ in CD3+ T lymphocytes after stimulation with SARS-CoV-2 spike (S1), nucleocapsid (NC), or receptor-binding domain (RBD) recombinant proteins or overlapping peptide pools covering the sequence of SARS-CoV-2 spike, membrane and nucleocapsid regions. The humoral response was examined by ELISAs and/or chemiluminescence assays for the presence of serum IgG antibodies directed to SARS-CoV-2 proteins. RESULTS: We observed differences between humoral and cellular immune profiles in response to stimulation with the same proteins. Assays of IgG antibodies directed to SARS-CoV-2 NC, RBD and S1/S2 recombinant proteins were able to differentiate convalescent from uninfected/unvaccinated groups. Cellular immune responses to SARS-CoV-2 protein stimuli did not exhibit a specific response, as T cells from both individuals with no history of contact with SARS-CoV-2 and from recovered donors were able to produce IFN-γ. CONCLUSIONS: Determination of the cellular immune response to stimulation with a pool of SARS-CoV-2 peptides but not with SARS-CoV-2 proteins is able to distinguish convalescent individuals from unexposed individuals. Regarding the humoral immune response, the screening for serum IgG antibodies directed to SARS-CoV-2 proteins has been shown to be specific for the response of recovered individuals.

https://doi.org/10.6061/clinics/2021/e3548

13.

Children’s Multisystem inflammatory syndrome with myopathy
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Azevedo, Zina Maria Almeida de

; Camacho, Karla Gonçalves

; Caixeta, Daniella Mancino da Luz

; Lima-Setta, Fernanda

; Salles, Tania Regina Dias Saad

; Góes, Fernanda Veiga de

; Nehab, Marcio Fernandes

; Figueiredo, Carlos Eduardo da Silva

; Leite, Maria de Fátima Monteiro Pereira

; Vasconcelos, Zilton Farias Meira de

; Melgaço, Juliana Gil

; Bom, Ana Paula Dinis Ano

; Moore, Daniella Campelo Batalha Cox

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0865-2020

Abstract: En | Text: En | PDF: En

Abstract This report describes a case of multisystem inflammatory syndrome in a child that evolved with a pattern of toxic shock syndrome with coronary artery ectasia and neurological involvement, documented by magnetic resonance imaging, with changes in the corpus callosum and myopathy in the pelvic girdle and paravertebral musculature.

https://doi.org/10.1590/0037-8682-0865-2020 416 downloads

14.

A COMUNICAÇÃO NA PROMOÇÃO DA DIGNIDADE EM CUIDADOS PALIATIVOS: DESAFIOS PARA A ENFERMAGEM
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Monho, Bruno Miguel Freire

; Ferreira, Inês Margarida Peralta

; Ribeiro, Mariana Ferreira Bernardino

; Alves, Tânia Sofia Cardoso

; Maurício, Maria Deolinda Antunes da Luz Lopes Dias

Revista Baiana de Enfermagem

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2021, Volume 35 elocation e34788

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Objective to understand the influence of communication as a basic nursing instrument in the promotion of dignity in Palliative Care. Method theoretical reflection through literature review and using Chochinov’s Dignity Model. The research of scientific articles was carried out on the online knowledge library, on the Elsevier publications database and on the database-aggregating platform EBSCO Host Web, published during the period 2010-2016. Results interventions associated with nurses’ communication skills that promote the dignity of clients in palliative care were identified. The communication interventions that most promote dignity are those that transmit to the palliative client respect for their individuality and appreciation of their personal history. Conclusion nurses should adopt a posture of empathic understanding, active listening, availability, attention to emotional needs, nonverbal components (such as physical presence and visual contact), management of expectations and encouragement of self-care.

Objetivo entender la influencia de la comunicación como instrumento básico de enfermería en la promoción de la dignidad en los Cuidados Paliativos. Método reflexión teórica a través de la revisión de la literatura y el uso del Modelo de Dignidad de Chochinov. La investigación de artículos científicos se llevó a cabo en la biblioteca de conocimientos en línea, en la base de datos de publicaciones Elsevier y en la plataforma agregadora de bases de datos EBSCO Host Web, publicados durante el período 2010-2016. Resultados se identificaron intervenciones asociadas a las habilidades de comunicación de las enfermeras que promueven la dignidad de los clientes en los cuidados paliativos. Las intervenciones de comunicación que más promueven la dignidad son las que transmiten al cliente paliativo el respeto por su individualidad y apreciación de su historia personal. Conclusión las enfermeras deben adoptar una postura empática de comprensión, escucha activa, disponibilidad, atención a las necesidades emocionales, componentes no verbales (como la presencia física y el contacto visual), gestión de expectativas y fomento del autocuidado.

Objetivo compreender a influência da comunicação enquanto instrumento básico de Enfermagem na promoção da dignidade em Cuidados Paliativos. Método reflexão teórica mediante revisão da literatura e com recurso ao Modelo da Dignidade de Chochinov. A pesquisa de artigos científicos foi realizada na biblioteca do conhecimento online, na base de dados das publicações Elsevier e na plataforma agregadora de bases de dados EBSCO Host Web, publicados durante o período 2010-2016. Resultados identificou-se intervenções associadas às competências comunicacionais dos enfermeiros que promovem a dignidade dos clientes em cuidados paliativos. As intervenções comunicacionais que mais promovem a dignidade são as que transmitem ao cliente paliativo o respeito pela sua individualidade e valorização da sua história pessoal. Conclusão o enfermeiro deve adotar uma postura de compreensão empática, escuta ativa, disponibilidade, atenção às necessidades emocionais, aos componentes não verbais (como a presença física e o contacto visual), à gestão de expectativas e o incentivo do autocuidado.

https://doi.org/10.18471/rbe.v35.34788 700 downloads

15.

Vitor Valla: uma vida de reflexão e militância em educação popular e saúde
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Lima, André Luiz da Silva

; Fernandes, Tania Maria Dias

Ciência & Saúde Coletiva

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oct 2019, Volume 24 N. 10 Pages 3727 - 3732

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O presente artigo busca estabelecer uma narrativa sobre alguns aspectos da trajetória acadêmica e militante do professor e educador popular Victor Valla, tendo como destaque uma problemática assinalada por ele em vários textos e debates, sobre a recorrente incompreensão de alguns pesquisadores e técnicos (assistentes sociais, educadores, médicos, enfermeiros, etc.) sobre as classes populares e suas falas. Valla ressaltava a existência de produção de conhecimento para além do circuito tradicional das universidades e centros de pesquisa, especialmente no âmbito das classes populares, que, para ele, estaria imbricada em suas práticas. Neste sentido, advogava uma nova postura teórica e metodológica para os projetos sociais, educacionais culturais e de saúde junto aos grupos populares, o que seria totalmente coerente e compatível com as premissas de um sistema de saúde democrático e equânime, apregoado pelos envolvidos com a área da Saúde.

Abstract The article explores aspects of the academic and activist life of the teacher and popular educator Victor Valla, particularly his repeated critiques, in writings and debates, about how some researchers and some social workers, educators, medical providers, and others working with the popular classes failed to understand these groups and their discourse. Valla embraced the idea that knowledge can be produced outside the traditional walls of universities and research centers, especially by the popular classes, who embed knowledge production in their very practices. In this regard, he advocated a new theoretical and methodological posture in social, cultural, educational, and health projects among the poor, in total consonance with the presuppositions of a democratic, equitable healthcare system, as supported by those involved in the health sector.

https://doi.org/10.1590/1413-812320182410.-00632019

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