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In this study, we aimed to investigate the anticancer activity of the extract, fractions, and isolated compounds of the flowers of Fridericia platyphylla, and to characterize the bioactive compounds. The chemical diversity of the extracts and fractions was investigated using liquid chromatography coupled with high resolution mass spectrometry (LC-HRMS). We were able to annotate 26 compounds from the classes of flavones, flavonols, flavanones, isoflavones, and cinnamic acid and its derivatives. The dichloromethane fraction showed greater cytotoxicity at a concentration of 100 µg mL−1. In addition, the inhibitory concentrations of the dichloromethane fraction were 22.14 and 30.9 µg mL−1 for MCF-7 and MDA-MB-231 cell lines, respectively, and were capable of inhibiting tumor cell migration. Brachydins A and C were isolated from the dichloromethane fraction and showed the greatest cytotoxicity. The results obtained from this study show the potential biological effect of F. platyphylla flowers as a possible antitumor pharmacological agent. extract LCHRMS. LCHRMS LC HRMS . (LC-HRMS) 2 flavones flavonols flavanones isoflavones derivatives 10 mL1 mL 1 addition 2214 22 14 22.1 309 30 9 30. mL− MCF7 MCF 7 MCF- MDAMB231 MDAMB MDA MB 231 MDA-MB-23 lines respectively migration F agent (LC-HRMS 221 22. 3 MDAMB23 23 MDA-MB-2 MDAMB2 MDA-MB- MDA-MB

https://doi.org/10.21577/0103-5053.20240132

Molecular Dynamics of the Neutralizing Potential of Dimeric IgA Antibodies against SARS-CoV-2 Antigen SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- SARS-CoV
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Oliveira, Micael D. L.

; Silva, Jonathas N.

; Cordeiro, Isabelle B.

; Lima, Ana Carolina O.

; Faria, Nathalia S.

; Santos, Clarice S.

; Bessa, João A. H.

; Freitas, Rosiane de

; Malheiro, Adriana

; Lima, Emersom S.

; Oliveira, Kelson M. T.

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 3 elocation e-20240157

Abstract: En | Text: En | PDF: En

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stands for being the most serious epidemic (so far) of the 21st century. However, only a few computational studies have investigated the molecular mechanisms underlying the neutralization of the spike protein by antibodies of different classes. Hence, bioinformatic methods were employed to unravel the factors contributing to the remarkable neutralization capacity exhibited by specific antibodies. Initially, crystallographic structures of IgA monomeric / dimeric, IgG, and IgM antibodies binding with the receptor-binding domain region of the SARS-CoV-2 spike protein were retrieved. Subsequently, rigid molecular docking and molecular dynamic simulations were performed over 100 ns with explicit water solvation. Lastly, an energy decomposition was conducted to estimate the binding affinity using the last frames from molecular dynamics. The results revealed a higher binding affinity for both monomeric and dimeric forms of IgA antibodies against the spike protein. Additionally, a greater number of hydrogen bonds were observed during their interaction with the spike protein, as well as greater structural instability along the time and especially a more thermodynamically favorable interaction affinity. In this way, the research contributes a small piece to the complex puzzle of understanding the humoral immune response induced by the SARS-CoV-2 virus. SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 so far st century However classes Hence Initially IgG receptorbinding receptor SARS-CoV- retrieved Subsequently 10 solvation Lastly dynamics Additionally way virus (SARS-CoV- SARS-CoV 1 (SARS-CoV

https://doi.org/10.21577/0103-5053.20240157

Optimizing roostertree biomass for arugula production in semi-arid regions semiarid semi arid
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Lima, Jailma S. S. de

; Bezerra Neto, Francisco

; Carmo, Iron D. de J. S. do

; Silva, Jéssica P. P. da

; Santos, Elizangela C. dos

; Azevedo, Marianne C. de

; Rodrigues, Gardênia S. de O.

; Frutuoso, Rebeca M. S.

Revista Caatinga

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2025, Volume 38 elocation e12604

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O aumento da fertilidade do solo no cultivo de hortaliças apresenta desafios, notadamente usando adubo verde de espécies espontâneas do bioma Caatinga, como a flor-de-seda (Calotropis procera [Ait.] R. Br.). Este estudo teve como objetivo avaliar e otimizar as eficiências física e econômica da rúcula em monocultivo, influenciadas por quantidades variáveis de biomassa de flor-de-seda. Um delineamento em blocos casualizados com sete tratamentos e cinco repetições foi utilizado. Os tratamentos consistiram de diferentes quantidades de biomassa de C. procera (20, 40, 60, 80 e 100 t ha-1 em base seca), juntamente com dois tratamentos adicionais em cada bloco: um controle (sem fertilização) e um com fertilização mineral. A cultivar de rúcula "Cultivada" foi adubada para máxima eficiência produtiva usando 63,31 t ha-1 de biomassa seca de C. procera, rendendo 8,45 t ha-1. A maior eficiência agroeconômica otimizada, refletindo uma renda líquida de R$ 111.007,64 por hectare, foi alcançada com 59,26 t ha-1 de biomassa seca de C. procera. A taxa de retorno foi de R$ 4,65 para cada real investido, com um índice de rentabilidade de 77,38%. Assim, utilizar biomassa de C. procera como adubo verde é uma tecnologia viável para produtores de rúcula em regiões semiáridas. desafios Caatinga flordeseda flor seda Calotropis Ait. Ait [Ait. R Br.. Br Br. . Br.) monocultivo flordeseda. seda. utilizado C 20, 20 (20 40 60 8 10 ha1 ha 1 ha- seca, , seca) bloco sem mineral Cultivada "Cultivada 6331 63 31 63,3 845 45 8,4 ha1. 1. otimizada 11100764 111 007 64 111.007,6 hectare 5926 59 26 59,2 465 4 65 4,6 investido 7738 77 38 77,38% Assim semiáridas [Ait 2 (2 6 633 3 63, 84 8, 1110076 11 00 111.007, 592 5 59, 46 4, 773 7 77,38 ( 111007 0 111.007 77,3 11100 111.00 77, 1110 111.0 111.

ABSTRACT Enhancing soil fertility in vegetable cultivation presents challenges, notably using green manure from spontaneous species in the Caatinga biome, such as roostertree (Calotropis procera [Ait.] R. Br.). This study aimed to evaluate and optimize the physical and economic efficiencies of monocropped arugula, as influenced by varying amounts of roostertree biomass. We employed a randomized block design with seven treatments and five replications. Treatments involved different quantities of C. procera biomass (20, 40, 60, 80, and 100 t ha-1 on a dry basis), along with two additional treatments in each block: a control (no fertilization) and one with mineral fertilization. The "Cultivada" arugula cultivar was fertilized for maximum productive efficiency using 63.31 t ha-1 of C. procera dry biomass, yielding 8.45 t ha-1. The highest optimized agroeconomic efficiency, reflecting a net income of BRL 111,007.64 per hectare, was achieved with 59.26 t ha-1 of C. procera dry biomass. The return rate was BRL 4.65 for every real investment, with a profitability index of 77.38%. Thus, using C. procera biomass as green manure is a viable technology for arugula producers in semi -arid regions. challenges biome Calotropis Ait. Ait [Ait. R Br.. Br Br. . Br.) replications C 20, 20 (20 40 60 80 10 ha1 ha 1 ha- basis, basis , basis) no fertilization Cultivada "Cultivada 6331 63 31 63.3 845 8 45 8.4 ha1. 1. 11100764 111 007 64 111,007.6 hectare 5926 59 26 59.2 465 4 65 4.6 investment 7738 77 38 77.38% Thus arid regions [Ait 2 (2 6 633 3 63. 84 8. 1110076 11 00 111,007. 592 5 59. 46 4. 773 7 77.38 ( 111007 0 111,007 77.3 11100 111,00 77. 1110 111,0 111,

https://doi.org/10.1590/1983-21252025v3812604rc

Morphological characterization of commercial okra accessions
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Lima, Francismária F. de

; Maciel, Kethily K. V.

; Nascimento, Thâmara P. do

; Bizerra, Maria M. S.

; Silva, Edicleide M. da

; Costa, Kleyton D. da S.

; Silva, Michelangelo de O.

; Nunes, Glauber H. de S.

Revista Caatinga

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2025, Volume 38 elocation e12440

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O quiabeiro (Abelmoschus esculentus L. Moench) é uma cultura pouco estudada, quando comparada a outras espécies da família Malvaceae, por isso apresenta grande potencial para estudos, principalmente, na área de melhoramento genético. A caracterização morfológica é uma etapa de pré-melhoramento que pode ser realizada através de descritores quantitativos e/ou qualitativos. Sendo assim, esse trabalho teve como objetivo caracterizar morfologicamente acessos comerciais de quiabeiro para delimitar um programa de melhoramento para a cultura. O experimento foi conduzido na área experimental do Instituto Federal de Alagoas - Campus Piranhas, utilizando o delineamento em blocos casualizados, com cinco tratamentos em cinco repetições. As plantas e os frutos foram caracterizados através dos descritores qualitativos. Foi utilizada a técnica de agrupamento hierárquico baseado na média não ponderada dos pares de acessos (UPGMA) para agrupar os acessos. A maior distância genética foi visualizada entre os acessos Santa Cruz-47 e Clemson Americano 80 e a menor entre os acessos Cariri e Apuim. Houve a formação de dois grupos pelo método de agrupamento UPGMA, sendo o grupo I formado pelos acessos Clemson Americano 80 e Canindé, e o grupo II dos demais acessos (Cariri, Apuim e Santa Cruz-47). Híbridos viáveis podem ser obtidos a partir de cruzamentos entre acessos do grupo I e do grupo II. Abelmoschus L Moench estudada Malvaceae estudos principalmente genético prémelhoramento pré eou ou qualitativos assim Piranhas casualizados repetições UPGMA (UPGMA Cruz47 Cruz 47 Cruz-4 8 Canindé Cariri, (Cariri Cruz47. . Cruz-47) Cruz4 4 Cruz-

ABSTRACT Okra (Abelmoschus esculentus L. Moench) has been less studied compared to other crop species of the family Malvaceae, thus presenting high potential for research, mainly in genetic improvement. Morphological characterization is a pre-breeding step that can be conducted using quantitative and qualitative descriptors. Thus, the objective of this study was to morphologically characterize commercial okra accessions to provide a foundation for breeding programs in this crop species. The experiment was conducted in the experimental area of the Federal Institute of Alagoas, Piranhas, AL, Brazil, using a randomized block design with five treatments and five replications. Okra plants and fruits were characterized through qualitative descriptors, using a hierarchical clustering of accessions based on Unweighted Pair Group Method with Arithmetic Mean (UPGMA). The greatest genetic distance was found between the Santa Cruz-47 and Clemson Americano-80 accessions, whereas the lowest distance was found between the Cariri and Apuim accessions. The UPGMA analysis resulted in two accession groups: group I consisting of Clemson Americano-80 and Canindé accessions, and group II consisting of Cariri, Apuim, and Santa Cruz-47 accessions. Viable hybrids can be obtained from crossings between accessions of group I and group II. Abelmoschus L Moench Malvaceae research improvement prebreeding pre descriptors Thus Alagoas Piranhas AL Brazil replications UPGMA. . (UPGMA) Cruz47 Cruz 47 Cruz-4 Americano80 Americano 80 Americano-8 groups (UPGMA Cruz4 4 Cruz- Americano8 8 Americano-

https://doi.org/10.1590/1983-21252025v3812440rc

Storage and quality of landrace cowpea grains stored in silo bags1 bags
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Silva, Mayara A. D. e

; Lopes, Lucas M.

; Sousa, Adalberto H. de

; Faroni, Lêda R. A.

; Brito, Rychaellen S. de

; Lima, Malena

; Andrade, Reginaldo A.

Revista Brasileira de Engenharia Agrícola e Ambiental

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nov 2024, Volume 28 N. 11 elocation e282159

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O armazenamento é uma etapa crucial durante a produção de grãos. Este trabalho foi realizado com o objetivo de avaliar o uso de silo bolsa como alternativa no armazenamento de grãos crioulos de feijão-caupi. Para o estudo utilizou-se amostras de feijão-caupi, das variedades Arigozinho, Manteiguinha e Quarentão, procedentes do município de Cruzeiro do Sul - Acre, safra 2021. As amostras de 500 g foram armazenadas em silos bolsa e sacos de ráfia, durante 30, 60, 90, 120 dias. O experimento foi inteiramente casualizado, com parcelas subdivididas no tempo (2 × 5), com quatro repetições. As parcelas foram as condições de armazenamento: silo bolsa e sacos de ráfia, e as subparcelas, os períodos de armazenamento: 0, 30, 60, 90 e 120 dias para cada variedade crioula de feijão-caupi. Zabrotes subfasciatus foi identificado em todas as variedades, com infestações de 49 a 98% em sacos de ráfia e inferiores a 10% em silo bolsa ao longo de 120 dias. Foi observado a depreciação na qualidade dos grãos durante o período de armazenamento em sacos de ráfia. Houve aumento na condutividade elétrica, flutuações no teor de água, redução da massa específica aparente e na germinação, devido ao maior grau de infestação em todas as variedades investigadas. Os grãos em silo bolsa apresentaram mínimas variações e mantiveram a qualidade inicial durante 120 dias. O armazenamento em silo bolsa é eficaz no controle de Z. subfasciatus e na manutenção da qualidade dos grãos das variedades Arigozinho, Manteiguinha e Quarentão por até 120 dias. feijãocaupi. feijãocaupi feijão caupi. caupi feijão-caupi utilizouse utilizou se feijãocaupi, caupi, Arigozinho Acre 2021 50 30 60 12 casualizado 2 ( 5, 5 , 5) repetições subparcelas 0 9 4 98 10 elétrica água germinação investigadas Z 202 3 6 1 20

ABSTRACT Storage is one of the main stages during grain production. The present study was conducted to evaluate the use of silo bags as an alternative for storing landrace cowpea grains. The experiment used samples of the Arigozinho, Manteiguinha, and Quarentão cowpea varieties from Cruzeiro do Sul - Acre, harvested in the 2021 crop season. The samples (500 g) were stored in raffia and silo bags for 30, 60, 90, and 120 days. The experimental design was completely randomized, arranged in a split-plot-in-time scheme (2 × 5) with four replicates. Storage conditions represented the plots: silo bags and raffia bags. The subplots comprised five storage conditions: 0, 30, 60, 90, and 120 days for each landrace cowpea variety. The insect species identified in all varieties was Zabrotes subfasciatus, with infestation ranging from 49% to 98% in raffia bags and less than 10% in silo bags over 120 days. A depreciation in grain quality was observed during storage in raffia bags. There was increase in electrical conductivity, fluctuations in water content, and reductions in bulk density and germination due to the higher degree of infestation in all the investigated varieties. The grains stored in silo bags showed minimal variations over the 120 days, maintaining their initial quality throughout the storage period. The bag silo storage system is an effective alternative for controlling Z. subfasciatus and maintaining the grain quality of the varieties Arigozinho, Manteiguinha, and Quarentão for a period of up to 120 days. production Arigozinho Manteiguinha Acre 202 season 500 (50 g 30 60 90 12 randomized splitplotintime split plot time 2 ( 5 replicates plots 0 variety 49 98 10 conductivity content Z 20 50 (5 3 6 9 1 4

https://doi.org/10.1590/1807-1929/agriambi.v28n11e282159

Resistance of forage grasses to Blissus pulchellus Montandon (Hemiptera: Blissidae) Hemiptera (Hemiptera Blissidae
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Simon, Jaime E.

; Medeiros, Roberto D. de

; Lima, Antonio C. S.

; Silva, Edgley S. da

; Dionisio, Luiz F. S.

Revista Brasileira de Engenharia Agrícola e Ambiental

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aug 2024, Volume 28 N. 8 elocation e280700

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os percevejos-das-gramíneas [Blissus pulchellus Montandon (Hemiptera: Blissidae)] sugam a seiva de espécies forrageiras suscetíveis e injetam toxinas que destroem os vasos condutores e dificultam o transporte de água e nutrientes, levando as plantas a morte. Assim, o objetivo deste estudo foi avaliar a resistência por antixenose e tolerância em oito poáceas forrageiras à B. pulchellus e comparar as características anatômicas dos tecidos das bainhas foliares de espécies/cultivares resistentes e suscetíveis. Os ensaios foram conduzidos em laboratório e casa de vegetação, em testes com e sem chance de escolha, utilizando-se as forrageiras: Urochloa ruziziensis, U. humidicola, U. brizantha ‘Piatã’, U. brizantha ‘Paiaguás’, U. brizantha ‘Marandu’, Panicum maximum ‘Mombaça’, P. maximum ‘Zuri’, e Andropogon gayanus. Os resultados de oviposição demonstraram que no teste de escolha houve uma mudança no comportamento do percevejo em relação às gramíneas quatro horas após infestação, sendo U. humidicola, P. maximum ‘Mombaça’ e ‘Zuri’, U. brizantha ‘Marandu’ e A. gayanus menos atrativos para os insetos. Conclui-se que U. humidicola, P. maximum ‘Mombaça’ e ‘Zuri’, U. brizantha ‘Marandu’, e A. gayanus são menos atrativas a B. pulchellus. A. gayanus, e P. maximum ‘Mombaça’ e ‘Zuri’ apresentam resistência do tipo não-preferência para oviposição a B. pulchellus. A resistência de U. humidicola, P. maximum Zuri, e A. gayanus a B. pulchellus pode estar associada a maior compactação e lignificação das células dos tecidos parenquimático e esclerenquimático das bainhas foliares. percevejosdasgramíneas percevejos Blissus Hemiptera (Hemiptera Blissidae Blissidae) nutrientes morte Assim B espéciescultivares cultivares vegetação utilizandose utilizando se ruziziensis U humidicola ‘Piatã, Piatã ‘Piatã , ‘Piatã’ ‘Paiaguás, Paiaguás ‘Paiaguás ‘Paiaguás’ ‘Marandu, Marandu ‘Marandu ‘Mombaça, Mombaça ‘Mombaça P ‘Zuri, Zuri ‘Zuri infestação insetos Concluise Conclui nãopreferência não preferência

ABSTRACT Chinch bugs [Blissus pulchellus Montandon (Hemiptera: Blissidae)] suck the phloem from susceptible forage grasses, injecting toxins that destroy plant vessels and compromise the flow of water and nutrients, leading to plant death. Thus, the aim of this study was to assess eight forage grasses for antixenosis resistance to B. pulchellus and compare the anatomical characteristics of leaf sheath tissue from resistant and susceptible species/cultivars. Experiments were conducted in a laboratory and greenhouse, using choice and no-choice tests with the following forage grasses: Urochloa ruziziensis, U. humidicola, U. brizantha ‘Piatã’, U. brizantha ‘Paiaguás’, U. brizantha ‘Marandu’, Panicum maximum ‘Mombaça’, P. maximum ‘Zuri’, and Andropogon gayanus. The oviposition results demonstrated that in the choice test there was a change in the stink bug’s behavior in relation to grasses four hours after infestation, with U. humidicola, P. maximum ‘Mombaça’ and ‘Zuri’, U. brizantha ‘Marandu’ and A. gayanus, proving to be less attractive to insects. It is concluded that U. humidicola, P. maximum ‘Mombaça’ and ‘Zuri’, U. brizantha ‘Marandu’, and A. gayanus are less attractive to B. pulchellus. A. gayanus and P. maximum ‘Mombaça’ and ‘Zuri’ showed non-preference resistance (antixenosis) to oviposition by B. pulchellus. The resistance of U. humidicola, P. maximum ‘Zuri’, and A. gayanus to B. pulchellus may be associated with greater compaction and lignification of the parenchyma and sclerenchyma cells of leaf sheaths. Blissus Hemiptera (Hemiptera Blissidae Blissidae) nutrients death Thus B speciescultivars species cultivars species/cultivars greenhouse nochoice no ruziziensis U humidicola ‘Piatã, Piatã ‘Piatã , ‘Piatã’ ‘Paiaguás, Paiaguás ‘Paiaguás ‘Paiaguás’ ‘Marandu, Marandu ‘Marandu ‘Mombaça, Mombaça ‘Mombaça P ‘Zuri, Zuri ‘Zuri bug s infestation A insects nonpreference non preference (antixenosis sheaths

https://doi.org/10.1590/1807-1929/agriambi.v28n8e280700

Dopamine depletion in wistar rats with epilepsy
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Trindade-Filho, E. M.

; Pai, J. Dal

; Castro, D. N. de

; Silva, A. T. M. da

; Costa, A. F.

; Vieira, J. S. S.

; Santos, S. D. B. dos

; Félix, V. B.

; Leão, S. A. B. F.

; Zambrano, L. I.

; Saldanha-Filho, A. J. M.

; Carvalho, E. G. A.

; Cavalcante, J. B. N.

; Quintella, G. B.

; Lino, A. T. S.

; Costa, M. V.

; Lima, J. A.

; Tavares, M. M. A.

; de Melo, M. R.

; Mousinho, K. C.

; Biase, C. L. C. L. De

; Leite, M. L.

; Costa, P. J. M. S.

; Becker, E. L.

; Moura, I. M. F. B.

; Silva, J. C. da

Brazilian Journal of Biology

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2024, Volume 84 elocation e248411

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O conteúdo de dopamina nas estruturas cerebrais tem sido relacionado à excitabilidade neuronal e várias abordagens têm sido utilizadas para estudar este fenômeno durante o período de vulnerabilidade às crises. No presente trabalho, descrevemos os efeitos da depleção de dopamina após a administração de 6-hidroxidopamina (6-OHDA) na região pars compacta da substância negra de ratos submetidos ao modelo de epilepsia com pilocarpina. A susceptibilidade ao estado de mal epiléptico induzido pela pilocarpina, bem como a frequência de crises espontâneas e recorrentes durante o período crônico do modelo foi determinada. Sendo o hipocampo uma das principais estruturas afetadas no desenvolvimento desse modelo experimental de epilepsia, os níveis de dopamina nessa região foram determinados após a administração da droga. No primeiro experimento, 62% (15/24) dos ratos pré-tratados com 6-OHDA e 45% (11/24) daqueles que receberam ácido ascórbico como solução controle evoluíram para crises límbicas motoras e para o estado de mal epiléptico, após a administração de pilocarpina. A gravidade das crises durante o período agudo do modelo foi significativamente maior nos ratos epilépticos experimentais (56,52%) do que nos ratos controle (4,16%). No segundo experimento, não houve diferença significante entre os grupos quanto à frequência de crises na fase crônica do modelo. Nossos dados mostraram que a dopamina pode desempenhar um papel importante na gravidade das crises na fase aguda da pilo, o que parece ser exercido por sua ação inibitória da dopamina sobre a expressão motora das crises.

Abstract The dopamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability period. In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. Since the hippocampus is one of main structures in the development of this experimental model of epilepsy, the dopamine levels in this region were also determined after drug administration. In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. Severeness of seizures during the model´s the acute period, was significantly higher in epileptic experimental rats (56.52%), than in controls (4.16%). In the second experiment, the frequency of seizures in the model’s chronic phase did not significantly change between groups. Our data show that dopamine may play an important role on seizure severity in the pilo’s model acute period, which seems to be due to dopamine inhibitory action on motor expression of seizure.

https://doi.org/10.1590/1519-6984.248411

A Combined Approach for Predicting Binding Affinity of Zika Virus NS2B-NS3 Protease Inhibitors Using Semi-Empirical Methods and Molecular Docking Algorithms NS2BNS3 NSBNS NS2B NS3 NS B NS2B-NS SemiEmpirical Semi Empirical BNS NS2BNS NSB
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Oliveira, Maycon Vinicius D. de

; Almeida, Leonardo L.

; Rocha, João A. P. da

; Wanzeller, Ana Lucia M.

; Lima, Anderson H.

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 3 elocation e-20230130

Abstract: En | Text: En | PDF: En

Zika virus (ZIKV) is a mosquito-borne virus that has emerged as a major public health concern due to its association with severe neurological disorders. In recent years, there has been increasing interest in exploring natural products as potential therapeutics for ZIKV infection. This study aimed to predict the binding affinity of natural compounds to the ZIKV NS2B-NS3 protease (NS2B-NS3pro) using multiple molecular docking algorithms and semiempirical quantum mechanical methods. Our results demonstrate that semiempirical methods can improve the accuracy of molecular docking studies for natural compounds. In this particular case, the PM7 (Parametric Method Number 7) method showed a significant improvement in the coefficient of determination (R2 = 0.85). We expect this combined approach to aid in the development of natural product-based therapies for ZIKV infection and to highlight the importance of continued research in this field. (ZIKV mosquitoborne mosquito borne disorders years NS2BNS3 NSBNS NS2B NS3 NS B NS2B-NS NS2BNS3pro NSBNSpro NS3pro pro (NS2B-NS3pro case PM Parametric 7 R2 R (R 0.85. 085 0.85 . 0 85 0.85) productbased product based field BNS NS2BNS NSB NSpro 08 0.8 8 0.

https://doi.org/10.21577/0103-5053.20230130

Hydrogen peroxide in attenuating salt stress in soursop
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Capitulino, Jessica D.

; Lima, Geovani S. de

; Azevedo, Carlos A. V. de

; Silva, André A. R. da

; Arruda, Thiago F. de L.

; Souza, Allesson R. de

; Soares, Lauriane A. dos A.

; Nascimento, Ronaldo do

Revista Caatinga

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2024, Volume 37 elocation e11876

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Em regiões semiáridas, a utilização de água salina para irrigação, tem se tornado uma realidade cada vez mais frequente em função da escassez qualitativa e quantitativa das fontes hídricas que ocorre na maior parte do ano. Assim, a utilização de peróxido de hidrogênio pode ser uma estratégia capaz de amenizar os efeitos deletérios do estresse salino sobre as plantas e garantir a produção agrícola de culturas, como a gravioleira. Deste modo, objetivou-se com esta pesquisa avaliar os efeitos da aplicação foliar de peróxido de hidrogênio sobre os índices fisiológicos e de crescimento de plantas de graviola cv. Morada Nova irrigadas com águas de diferentes níveis salinos. Os tratamentos foram distribuídos em um delineamento de blocos casualizados, em esquema fatorial 4 × 4, correspondendo a quatro níveis de condutividade elétrica da água de irrigação e quatro concentrações de peróxido de hidrogênio, com três repetições. A aplicação foliar de peróxido de hidrogênio nas concentrações de 12, 18 e 15µM, respectivamente, atenuaram os efeitos do estresse salino sobre a condutância estomática, a taxa de assimilação de CO2 e a síntese de clorofila a de gravioleira, aos 780 dias após o transplantio. A concentração de peróxido de hidrogênio de 30 µM intensificou o estresse salino sobre as trocas gasosas, a fluorescência variável e o extravasamento de eletrólitos no limbo foliar de plantas de graviola cv. Morada Nova, aos 780 dias após o transplantio. semiáridas ano Assim culturas gravioleira modo objetivouse objetivou cv salinos casualizados repetições 12 1 15µM respectivamente estomática CO 78 transplantio 3 gasosas 7

ABSTRACT In semi-arid regions, the use of saline water for irrigation has become an increasingly frequent reality due to the qualitative and quantitative scarcity of water sources occurring most of the year. Thus, the use of hydrogen peroxide can be a strategy capable of mitigating the deleterious effects of salt stress on plants and guaranteeing the agricultural production of crops such as soursop. Thus, the objective of this study was to evaluate the effects of foliar application of hydrogen peroxide on the physiological and growth indices of soursop plants cv. Morada Nova irrigated with waters of different salinity levels. The treatments were distributed in a randomized block design, in a 4 × 4 factorial scheme, corresponding to four levels of electrical conductivity of irrigation water and four concentrations of hydrogen peroxide, with three replicates. Foliar application of hydrogen peroxide at concentrations of 12, 18 and 15 µM, respectively, attenuated the effects of salt stress on stomatal conductance, CO2 assimilation rate and chlorophyll a synthesis of soursop, at 780 days after transplanting. The 30 µM hydrogen peroxide concentration intensified salt stress on gas exchange, variable fluorescence and electrolyte leakage in the leaf blade of soursop plants cv. Morada Nova, 780 days after transplanting. semiarid semi arid regions year Thus cv design scheme replicates 12 1 respectively conductance CO 78 transplanting 3 exchange 7

https://doi.org/10.1590/1983-21252024v3711876rc

10.

Vaccination coverage survey by social stratum in children up to 24 months of age in Londrina, Paraná, Brazil, between 2021 and 2022
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Oliveira, Edmilson de

; Moraes, José Cássio de

; França, Ana Paula

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 N. spe2 elocation e20231393

Abstract: Pt Es En | Text: Pt Es En | PDF: Pt | PDF: Es | PDF: En

RESUMO Objetivo Analisar a cobertura vacinal segundo estrato social, em crianças até 24 meses de vida, residentes no município de Londrina (PR). Métodos Inquérito de base populacional, realizado entre em 2021 e 2022, em que se avaliou a cobertura vacinal e os aspectos sociodemográficos das mães e das famílias, através do teste qui-quadrado de Pearson. Resultados Em uma amostra de 456 crianças, a cobertura vacinal completa variou de acordo com o estrato social, sendo no estrato A de 36,0% (IC95% 26,8;57,8); no estrato B, de 59,5% (IC95% 26,1;86); no estrato C, de 66,2% (IC95% 51,7;78,1); e no estrato D, de 70,0% (IC95% 56,1;81,0). Conclusão A análise da cobertura vacinal indicou o estrato social A como o de maior risco para doenças prevenidas por vacinas.

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ABSTRACT Objective To analyze vaccination coverage according to social strata in children up to 24 months old, living in the municipality of Londrina (PR), Brazil. Methods This was a population-based survey conducted between 2021 and 2022, in which vaccination coverage and sociodemographic aspects of mothers and families were evaluated using Pearson’s chi-square test. Results In a sample of 456 children, complete vaccination coverage varied according to social strata, being 36.0% (95%CI 26.8;57.8); in stratum A; 59.5% (95%CI 26.1;86); in stratum B; 66.2% (95%CI 51.7;78.1); in stratum C; and 70.0% (95%CI 56.1;81.0) in stratum D. Conclusion The analysis of vaccination coverage indicated that social stratum A is at highest risk for vaccine-preventable diseases.

https://doi.org/10.1590/s2237-96222024v33e20231393.especial2.en

11.

Proline on the induction of tolerance of sour passion fruit seedlings to salt stress
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Santos, Larissa F. S.

; Lima, Geovani S. de

; Lima, Vera L. A. de

; Silva, André A. R. da

; Fátima, Reynaldo T. de

; Arruda, Thiago F. de L.

; Soares, Lauriane A. dos A.

; Capitulino, Jessica D.

Revista Caatinga

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2024, Volume 37 elocation e12048

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO As fontes hídricas do semiárido brasileiro comumente apresentam altos teores de sais dissolvidos em sua composição, destacando-se como um dos estresses abióticos que limita a expansão da fruticultura irrigada, principalmente de culturas sensíveis ao estresse salino como o maracujazeiro-azedo. Assim, a utilização de substâncias elicitoras, como prolina, pode ser uma alternativa eficaz para mitigar o estresse salino nas plantas. Nesse contexto, objetivouse com este trabalho avaliar os efeitos da aplicação foliar de prolina na fluorescência da clorofila, crescimento, qualidade e tolerância de maracujazeiro-azedo irrigados com águas salinas durante a fase de formação de mudas. A pesquisa foi conduzida no período de julho a outubro de 2022, em casa de vegetação em Campina Grande - PB, utilizando-se o delineamento inteiramente casualizado, em esquema fatorial 5 × 4, sendo cinco níveis de condutividade elétrica da água de irrigação CEa - (0,6; 1,2; 1,8; 2,4 e 3,0 dS m-1) e quatro concentrações de prolina (0, 5, 10 e 15 mM) com quatro repetições e duas plantas por parcela. A salinidade da água a partir de 0,6 dS m-1 reduz a fluorescência máxima, variável, eficiência quântica do fotossistema II e o crescimento de mudas maracujazeiro-azedo ‘BRS GA1’. A aplicação foliar de prolina em concentração variando de 6 a 8,05 mM aumenta o crescimento em altura de plantas, diâmetro de caule e área foliar de mudas de maracujazeiro-azedo. O genótipo de maracujazeiro-azedo ‘BRS GA1’ é sensível a salinidade da água, sendo o nível de salinidade limiar de 0,6 dS m-1 e a redução por aumento unitário da condutividade elétrica de 10,49%. composição destacandose destacando se irrigada maracujazeiroazedo. maracujazeiroazedo maracujazeiro azedo. azedo Assim elicitoras contexto clorofila 2022 PB utilizandose utilizando casualizado 4 06 0 (0,6 1,2 12 1 2 1,8 18 8 24 2, 30 3 3, m1 m 0, (0 parcela m- máxima variável BRS GA1. GA1 GA . 805 05 8,0 1049 49 10,49% 202 1, ( 80 8, 104 10,49 20 10,4 10,

ABSTRACT Water sources in the Brazilian semi-arid region commonly contain high levels of dissolved salts in their composition, standing out as one of the abiotic stresses that limit the expansion of irrigated fruit growing, especially salt stress-sensitive crops such as sour passion fruit. Thus, the use of elicitors, such as proline, can be an effective alternative to mitigate salt stress in plants. In this context, the objective of this study was to evaluate the effects of foliar application of proline on chlorophyll fluorescence, growth, quality and tolerance of sour passion fruit irrigated with saline water during the seedling formation phase. The experiment was conducted from July to October 2022, under greenhouse conditions in Campina Grande, PB, Brazil, using a completely randomized design, in a 5 × 4 factorial scheme, with five levels of electrical conductivity of irrigation water - ECw (0.6, 1.2, 1.8, 2.4 and 3.0 dS m-1) and four concentrations of proline (0, 5, 10 and 15 mM), with four replicates and two plants per plot. Water salinity from 0.6 dS m-1 reduces the maximum fluorescence, variable fluorescence, quantum yield of photosystem II and growth of ‘BRS GA1’ sour passion fruit seedlings. Foliar application of proline at concentrations ranging from 6 to 8.05 mM increases the growth in plant height, stem diameter and leaf area of sour passion fruit seedlings. The sour passion fruit genotype ‘BRS GA1’ is sensitive to water salinity, with a salinity threshold level of 0.6 dS m-1 and a reduction per unit increase in electrical conductivity of 10.49%. semiarid semi arid composition growing stresssensitive Thus elicitors context fluorescence phase 2022 Grande PB Brazil design scheme 0.6, 06 0 (0.6 12 1 2 1.2 18 8 1.8 24 2. 30 3 3. m1 m 0, (0 mM, , mM) plot 0. m- BRS GA1 GA seedlings 805 05 8.0 height 1049 49 10.49% 202 (0. 1. ( 80 8. 104 10.49 20 10.4 10.

https://doi.org/10.1590/1983-21252024v3712048rc

12.

Obituary: Nelio Roberto dos Reis (1950-2023) Obituary 19502023 1950 2023 (1950-2023 1950202 195 202 (1950-202 195020 19 20 (1950-20 19502 1 2 (1950-2 (1950- (1950 (195 (19 (1 (
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Peracchi, Adriano L.

; Pereira, Alan D.

; Batista, Carolina B.

; Cheida, Carolina C.

; Lima, Isaac P. de

; Sekiama, Margareth L.

; Rocha, Vlamir J.

; Pedro, Wagner A.

Zoologia (Curitiba)

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2024, Volume 41 elocation e24013

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/s1984-4689.v41.e24013

13.

Design, synthesis and identification of novel molecular hybrids based on naphthoquinone aromatic hydrazides as potential trypanocide and leishmanicidal agents Design
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CEZAR, ROSANE D.

; SILVA, ADRIANO O. DA

; LOPES, ROSÂNGELA S.

; NAKAMURA, CELSO V.

; RODRIGUES, JEAN HENRIQUE S.

; LOURENÇO, ESTELA MARIANA G.

; SABA, SUMBAL

; BEATRIZ, ADILSON

; RAFIQUE, JAMAL

; LIMA, DÊNIS P. DE

Anais da Academia Brasileira de Ciências

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2024, Volume 96 N. 2 elocation e20230375

Abstract: En | Text: En | PDF: En

Abstract In pursuit of potential agents to treat Chagas disease and leishmaniasis, we report the design, synthesis, and identification novel naphthoquinone hydrazide-based molecular hybrids. The compounds were subjected to in vitro trypanocide and leishmanicidal activities. N’-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)-3,5-dimethoxybenzohydrazide (13) showed the best performance against Trypanosoma cruzi (IC50 1.83 µM) and Leishmania amazonensis (IC50 9.65 µM). 4-Bromo-N’-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)benzohydrazide (16) exhibited leishmanicidal activity (IC50 12.16 µM). Regarding trypanocide activity, compound 13 was low cytotoxic to LLC-MK2 cells (SI = 95.28). Furthermore, through molecular modeling studies, the cysteine proteases cruzain, rhodesain and CPB2.8 were identified as the potential biological targets. leishmaniasis design synthesis hydrazidebased hydrazide based hybrids activities N1,4Dioxo1,4dihydronaphthalen2yl3,5dimethoxybenzohydrazide N14Dioxo14dihydronaphthalen2yl35dimethoxybenzohydrazide NDioxodihydronaphthalenyldimethoxybenzohydrazide N 1,4 Dioxo dihydronaphthalen 2 yl 3,5 dimethoxybenzohydrazide 1 4 3 5 (13 IC50 IC (IC5 183 83 1.8 µM 965 9 65 9.6 µM. . 4BromoN1,4dioxo1,4dihydronaphthalen2ylbenzohydrazide 4BromoN14dioxo14dihydronaphthalen2ylbenzohydrazide BromoNdioxodihydronaphthalenylbenzohydrazide Bromo dioxo benzohydrazide 16 (16 1216 12 12.1 LLCMK2 LLCMK LLC MK2 MK LLC-MK SI 95.28. 9528 95.28 95 28 95.28) Furthermore studies cruzain CPB28 CPB CPB2 8 CPB2. targets N1 4Dioxo1 4dihydronaphthalen2yl3 5dimethoxybenzohydrazide 14 1, 35 3, (1 IC5 (IC 18 1. 96 6 9. 4BromoN1 4dioxo1 4dihydronaphthalen2ylbenzohydrazide BromoN ylbenzohydrazide 121 12. 952 95.2 4Dioxo dihydronaphthalenyl 4dihydronaphthalen2yl ( 4BromoN 4dioxo dihydronaphthalenylbenzohydrazide 95.

https://doi.org/10.1590/0001-3765202420230375

14.

AVALIAÇÃO QUANTITATIVA DE ÁCIDOS AMARGOS, XANTHOHUMOL E ÓLEOS ESSENCIAIS PRESENTES EM FLORES DE DIFERENTES CULTIVARES DE Humulus lupulus L. PRODUZIDAS NA REGIÃO NORDESTE DO BRASIL AMARGOS L
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Marques, Samuel P. D.

; Trevisan, Maria T. S.

; Owen, Robert W.

; Silva, Ana M. A.

; Nascimento, Francisco M. G.

; Lima, Francisca S. S.

; Lima, Thales C.

; Brito, Edy S. de

; Magalhães, Hilton C. R.

; Silva, Francisco L. F. da

Química Nova

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2024, Volume 47 N. 2 elocation e-20230092

Abstract: Pt | Text: Pt | PDF: Pt

Hop flowers contain chemical substances that are used to confer sensory properties to beer. Hop flower products have very high commercial value, but national production represents less than 2% of domestic consumption. In this work, flowers from different hop cultivars grown in northeast of Brazil (Rio Grande do Norte and Ceará) were analyzed to quantitate metabolites of industrial interest. Flowers from the initial and three consecutive harvests were collected, and bitter acids and xanthohumol were evaluated by HPLC-UV and essential oils by GC-MS. The cultivar Columbus was subjected to only 10% of the irrigation time during the third flowering phase to evaluate the effect of water stress on the formation of metabolites. Compounds were detected in appreciable quantities in all samples, and consecutive flowering of some cultivars showed a significant increase in total bitter acids with successive harvests. Plants subjected to water stress showed an abrupt decrease in the concentration of compounds. The cultivars evaluated by liquid and gas chromatography showed a significant concentration of bitter acids and essential oils within the expected range, and the chemical composition of the oils showed different compounds characteristic of hops. beer value 2 consumption work Rio Ceará interest collected HPLCUV HPLC UV GCMS. GCMS GC MS. MS GC-MS 10 samples range hops 1

https://doi.org/10.21577/0100-4042.20230092

15.

Effect of Photoluminescence of Nanomaterials to Verify Corrosion in Carbon Steel
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Leitão, Juliana S. Osterno

; Lima, Francisco M.

; Girão, Daniel de C.

; Fechine, Lillian M. U. D.

; Carneiro, Samuel V.

; Oliveira, Ralph S.

; Freire, Francisco N. A

; Amorim, A. F. Valentim de

; Fechine, Pierre B. A.

; Araújo, Walney Silva

; Rocha, Janaína S.

Materials Research

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2024, Volume 27 Suppl. 1 elocation e20240045

Abstract: En | Text: En | PDF: En

The use of fluorescent nanomaterials in various fields of study has become increasingly common. In this work, the use of carbon quantum dots as a corrosion marker in carbon steel is proposed. To produce the sensor, carbon quantum dots based on ethylenediamine and citric acid were used, dissolved in a polymeric matrix. The quantum dot used showed a quantum yield of 42.34%. The nanomodified coatings emitted blue light under ultraviolet radiation lamp. However, it was observed that there is a loss of photoluminescence in the coating on the carbon steel substrate compared to the coating on the polymeric substrate, which maintained photoluminescence activity after natural exposure. Thus, it is inferred that the loss of photoluminescence may be associated with the corrosion process. common work proposed sensor matrix 4234 42 34 42.34% lamp However exposure Thus process 423 4 3 42.34 42.3 42.

https://doi.org/10.1590/1980-5373-mr-2024-0045

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