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au:Cruz, Maria Letícia Santos

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Arranjos e inovações para o cuidado em saúde mental no enfrentamento da COVID-19: revisão integrativa COVID19 COVID 19 COVID-19 COVID1 1 COVID-1 COVID-
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Silva, Amanda Seraphico Carvalho Pereira da

; Furtado, Lumena Almeida Castro

; Tofani, Luís Fernando Nogueira

; Bigal, André Luiz

; Bragagnolo, Larissa Maria

; Vieira, Amanda da Cruz Santos

; Lima, Carolina Loyelo

; Oliveira, Letícia Bucioli

; Chioro, Arthur

Ciência & Saúde Coletiva

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aug 2024, Volume 29 N. 8 elocation e06532023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A presente revisão integrativa tem por objetivo identificar os arranjos de cuidado em saúde mental que foram implementados no enfrentamento à pandemia de COVID-19. Realizou-se busca em três bases de dados (SciELO, PubMed e LILACS), em português, inglês e espanhol, com os descritores “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19”, no período de 2020 a 2021. Foram encontrados 3.451 artigos, sendo 43 selecionados para análise. Em relação ao cuidado em saúde mental, os principais arranjos identificados foram os digitais, de natureza pública, desenvolvidos na esfera municipal e com integração com a rede de saúde. Os modelos de cuidado em saúde mental para o enfrentamento da pandemia são discutidos a partir dos tipos de arranjo produzidos nesse contexto sanitário emergencial e crítico. Apresenta-se, ainda, um recorte da realidade encontrada no Sistema Único de Saúde (SUS), reiterando sua resiliência. Concluiu-se que os arranjos digitais foram os mais usados e que há necessidade de investigar a acessibilidade deste modelo para populações com maior vulnerabilidade social. Reafirma-se a importância do SUS para o enfrentamento da COVID-19 e no acesso a informações de saúde. COVID19. COVID19 COVID 19. 19 Realizouse Realizou se SciELO, SciELO (SciELO LILACS, LILACS , LILACS) português espanhol SAÚDE MENTAL SALUD HEALTH COVID19, “COVID-19” 202 2021 3451 3 451 3.45 artigos 4 análise pública crítico Apresentase, Apresentase Apresenta se, Apresenta-se ainda SUS, (SUS) resiliência Concluiuse Concluiu social Reafirmase Reafirma COVID-1 COVID1 1 “COVID-19 20 345 45 3.4 (SUS COVID- “COVID-1 2 34 3. “COVID- “COVID

Abstract This integrative review aims to identify the mental health care measures that were produced during the COVID-19 pandemic. This research was conducted on three databases (SciELO, PubMed, and LILACS) with the following descriptors in Portuguese, English, and Spanish: “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19” from 2020 to 2021. In total, 3,451 articles were found, 43 of which were analyzed. Most measures were digital, stemmed from public institutions, focused on the local perspective, and were integrated with the public health care system. This study discusses the models of care in mental health based on measures to cope with the COVID-19 pandemic. It also discusses the Brazilian health care system, reiterating its resilience. In conclusion, digital measures occurred most often. This study suggest the evaluation of the accessibility of this mental health care model for most vulnerable groups. Finally, this research reinforces the importance of the Brazilian health care system for public health and access to information to cope with the COVID-19 pandemic. COVID19 COVID 19 COVID-1 pandemic SciELO, SciELO (SciELO PubMed LILACS Portuguese English Spanish SAÚDE MENTAL SALUD HEALTH “COVID-19 202 2021 total 3451 3 451 3,45 found 4 analyzed institutions perspective resilience conclusion often groups Finally COVID1 1 COVID- “COVID-1 20 345 45 3,4 “COVID- 2 34 3, “COVID

https://doi.org/10.1590/1413-81232024298.06532023

Arranjos e inovações para o cuidado em saúde mental no enfrentamento da COVID-19: revisão integrativa
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Silva, Amanda Seraphico Carvalho Pereira da

; Furtado, Lumena Almeida Castro

; Tofani, Luís Fernando Nogueira

; Bigal, André Luiz

; Bragagnolo, Larissa Maria

; Vieira, Amanda da Cruz Santos

; Lima, Carolina Loyelo

; Oliveira, Letícia Bucioli

; Chioro, Arthur

Ciência & Saúde Coletiva

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2024, Volume 29 N. 8 elocation e06532023

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024298.06532023

The Zebrafish as an Alternative Animal Model for Ecotoxicological Research and Testing
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Braga, Ana Paula Andrade

; Souza, Leticia Rosa de

; Lima, Maria Gabriela Franco

; Cruz, Jaqueline Matos

; Souza, Ana Cristina Zullo de

; Costa, Mariana Santos

; Castro, Vera Lucia Scherholz Salgado de

; Marin-Morales, Maria Aparecida

Brazilian Archives of Biology and Technology

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2024, Volume 67 elocation e24220968

Abstract: En | Text: En | PDF: En

Abstract Anthropogenic interventions have had a compromising effect on environmental health, intensifying the degradation of ecosystems, and the quantity of chemical pollutants released into nature. Therefore, research areas within the scope of environmental assessments and monitoring such as ecotoxicology have contributed to the determination of the toxic potential of contaminants. A small cyprinid known as the zebrafish (Danio rerio), the use of which has exponentially grown, is an alternative vertebrate model for scientific research, mainly in the assessment of environmental risks. The species exhibits several advantages for breeding in a laboratory, in addition to presenting multi-biomarkers of environmental toxicity. Thus, this review aims to present the main characteristics and advantages of working with this species, as well as show studies related to ecotoxicology involving biomarkers of toxicity in zebrafish. The results show a progressive trend towards employing the species in environmental risk analyses, it is an increasingly recommended species in the assessment of the toxicity level of a range of chemical pollutants. The development of future technologies must contribute to scientific advancement, rendering the potential application of this model organism an even more widespread one, which will certainly help in bridging knowledge gaps in various areas of study. health ecosystems nature Therefore contaminants Danio rerio, rerio , rerio) grown risks laboratory multibiomarkers multi Thus analyses advancement one study

https://doi.org/10.1590/1678-4324-2024220968

Posicionamento Brasileiro sobre o Uso da Multimodalidade de Imagens na Cardio-Oncologia – 2021
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Melo, Marcelo Dantas Tavares de

; Paiva, Marcelo Goulart

; Santos, Maria Verônica Câmara

; Rochitte, Carlos Eduardo

; Moreira, Valéria de Melo

; Saleh, Mohamed Hassan

; Brandão, Simone Cristina Soares

; Gallafrio, Claudia Cosentino

; Goldwasser, Daniel

; Gripp, Eliza de Almeida

; Piveta, Rafael Bonafim

; Silva, Tonnison Oliveira

; Santo, Thais Harada Campos Espirito

; Ferreira, Waldinai Pereira

; Salemi, Vera Maria Cury

; Cauduro, Sanderson A.

; Barberato, Silvio Henrique

; Lopes, Heloísa M. Christovam

; Pena, José Luiz Barros

; Rached, Heron Rhydan Saad

; Miglioranza, Marcelo Haertel

; Pinheiro, Aurélio Carvalho

; Vrandecic, Bárbara Athayde Linhares Martins

; Cruz, Cecilia Beatriz Bittencourt Viana

; Nomura, César Higa

; Cerbino, Fernanda Mello Erthal

; Costa, Isabela Bispo Santos da Silva

; Coelho Filho, Otavio Rizzi

; Carneiro, Adriano Camargo de Castro

; Burgos, Ursula Maria Moreira Costa

; Fernandes, Juliano Lara

; Uellendahl, Marly

; Calado, Eveline Barros

; Senra, Tiago

; Assunção, Bruna Leal

; Freire, Claudia Maria Vilas

; Martins, Cristiane Nunes

; Sawamura, Karen Saori Shiraishi

; Brito, Márcio Miranda

; Jardim, Maria Fernanda Silva

; Bernardes, Renata Junqueira Moll

; Diógenes, Tereza Cristina

; Vieira, Lucas de Oliveira

; Mesquita, Claudio Tinoco

; Lopes, Rafael Willain

; Segundo Neto, Elry Medeiros Vieira

; Rigo, Letícia

; Marin, Valeska Leite Siqueira

; Santos, Marcelo José

; Grossman, Gabriel Blacher

; Quagliato, Priscila Cestari

; Alcantara, Monica Luiza de

; Teodoro, José Aldo Ribeiro

; Albricker, Ana Cristina Lopes

; Barros, Fanilda Souto

; Amaral, Salomon Israel do

; Porto, Carmen Lúcia Lascasas

; Barros, Marcio Vinícius Lins

; Santos, Simone Nascimento dos

; Cantisano, Armando Luís

; Petisco, Ana Cláudia Gomes Pereira

; Barbosa, José Eduardo Martins

; Veloso, Orlando Carlos Glória

; Spina, Salvador

; Pignatelli, Ricardo

; Hajjar, Ludhmilla Abrahão

; Kalil Filho, Roberto

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Vieira, Marcelo Luiz Campos

; Almeida, André Luiz Cerqueira

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 845 - 909

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200266 103 downloads

Estigma relacionado ao HIV entre jovens em transição para a clínica de adultos num hospital público no Rio de Janeiro, Brasil
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Cruz, Maria Letícia Santos

; Darmont, Mariana de Queiroz Rocha

; Monteiro, Simone Souza

Ciência & Saúde Coletiva

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jul 2021, Volume 26 N. 7 Pages 2653 - 2662

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Neste estudo investigamos como vivências de estigma do HIV se expressam entre jovens soropositivos, em transição para a clínica de adultos, no serviço de saúde, na família e nas interações afetivos-sexuais e sua relação com as desigualdades e hierarquias sociais. O estudo envolveu 31 jovens (idade mediana 21) em transição para a clínica de adultos (G1) e 12 jovens (idade mediana 30) que já fizeram essa transição (G2), ambos atendidos num serviço de saúde do Rio de Janeiro. Dentre os 43 jovens, 70% eram mulheres e 65% foi infectado por transmissão vertical. Os jovens responderam a questionários e participaram de grupos focais sobre estigma da aids e passagem para a vida adulta. A maioria relatou situações de discriminação associadas ao estigma do HIV na vida cotidiana e no cuidado em saúde. Os jovens do G1 revelaram maior preocupação com as consequências da revelação do HIV e dificuldades com o tratamento. Os relatos do G2 sugerem que a constituição de relações conjugais, incluindo parceiro/a e filhos soronegativos e o acesso ao tratamento, possibilitaram resignificar o receio da estigmatização. Os achados visam orientar a formação e ação de profissionais envolvidos na prevenção e cuidado de jovens vivendo com HIV.

Abstract This study analyzes how experiences of HIV-related stigma are expressed among HIV-positive young people transitioning to an adult clinic, the health service, the family, the affective-sexual interactions, and their relationship with inequalities and social hierarchies. This research included 31 young people (median age 21) transitioning to an adult clinic (G1) and 12 young people (median age 30) who had already made this transition (G2), both monitored at a health service in Rio de Janeiro. Seventy percent of the 43 young people were women and 65% were infected by mother-to-child transmission. Young people answered questionnaires and participated in focus groups on AIDS stigma and transition to adulthood. Most reported discrimination associated with HIV stigma in daily life and health care. G1 young people showed more significant concern about the consequences of HIV disclosure and difficulties with treatment. The G2 accounts suggest that establishing marital relationships, including HIV-negative partners and children, linked to treatment access allowed resignifying the fear of stigmatization. The findings aim to guide the training and action of professionals involved in the prevention and care of young people living with HIV.

https://doi.org/10.1590/1413-81232021267.07422021 413 downloads

Estigma relacionado ao HIV entre jovens em transição para a clínica de adultos num hospital público no Rio de Janeiro, Brasil
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Cruz, Maria Letícia Santos

; Darmont, Mariana de Queiroz Rocha

; Monteiro, Simone Souza

Ciência & Saúde Coletiva

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2021, Volume 26 N. 7 Pages 2653 - 2662

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232021267.07422021

Diagnosis of pulmonary tuberculosis in children and adolescents: comparison of two versions of the Brazilian Ministry of Health scoring system
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Carvalho, Roberta Feijó

; Carvalho, Anna Cristina Calçada

; Velarde, Luis Guillermo Coca

; Rossoni, Andrea Maciel de Oliveira

; Aurilio, Rafaela Baroni

; Sias, Selma Maria de Azevedo

; Schmidt, Christiane Mello

; Moreira, Adriana da Silva Rezende

; Martins, Pedro da Silva

; Gonçalves, Lorrayne Isidoro

; Martire, Terezinha Miceli

; Barbosa, Ana Paula Ferreira

; Santos, Ana Paula Quintanilha dos

; Romanelli, Roberta Maia de Castro

; Oliveira, Maria das Graças Rodrigues de

; Diniz, Lilian Martins Oliveira

; Carvalho, Andrea Lucchesi de

; Lucena, Sheila Cunha

; Cruz, Maria Letícia Santos

; Saavedra, Mariza Curto

; Tahan, Tony Tannous

; Rodrigues, Cristina de Oliveira

; Kritski, Afrânio Lineu

; Sant’Anna, Clemax Couto

; Cardoso, Claudete Aparecida Araújo

; Sant’Anna, Maria de Fátima Bazhuni Pombo

Revista do Instituto de Medicina Tropical de São Paulo

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2020, Volume 62 elocation e81

Abstract: En | Text: En | PDF: En

ABSTRACT The aim of this study was to evaluate the concordance between two versions of the scoring system (2011 and 2019), recommended by the Brazilian Ministry of Health, for the diagnosis of pulmonary tuberculosis (PTB) in children and adolescents. A retrospective descriptive study was performed to assess the medical records of children and adolescents with PTB, in TB units from Brazilian cities located in Rio de Janeiro, Minas Gerais, and Parana States, from January 1 st , 2004, to December 1 st , 2018. Patients aged 0 to 18 years old with a diagnosis of PTB were included. The comparison between the two scoring systems showed a moderate concordance according to the κ coefficient value = 0.625. Fourteen patients showed a reduction in the TB score, going from 30 points in the 2011, to 25 points or less in the 2019 one. Seventy one percent of these 14 patients had radiological changes suggestive of PTB and 86% had tuberculin skin tests greater than 10 mm. The study concluded that a moderate agreement was observed between the 2011 and 2019 scoring systems, with an increase in the number of patients scoring 25 points or less in 2019, which can eventually hinder the diagnosis of PTB.

https://doi.org/10.1590/s1678-9946202062081 664 downloads

Option for the Radial versus Femoral Access in Coronary Intervention in Acute Coronary Syndromes: A Risk-Treatment Paradox
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Lacerda, Yasmin Falcon

; Sá, Nicole Cruz de

; Suerdieck, Jessica Gonzalez

; Fonseca, Letícia

; Lopes, Fernanda

; Sodré, Gabriella Sant'Ana

; Viana, Mateus dos Santos

; Rabelo, Marcia Maria Noya

; Correia, Luis Claudio Lemos

International Journal of Cardiovascular Sciences

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dec 2018, Volume 31 N. 6 Pages 562 - 568

Abstract: En | Text: En | PDF: En

Abstract Background: In coronary procedures, although the radial approach protects patients from hemorrhagic complications, it is technically more complex than the femoral approach. Objectives: To test the hypothesis that the radial approach is the procedure of choice in ACS patients due to the high risk of bleeding; and to identify independent predictors of the choice for radial access. Methods: Patients admitted for ACS who underwent invasive coronary procedure were included. We registered the type of access (femoral or radial) chosen by the physician for the first angiography; the investigators did not interfere with this choosing process. Student’s t-test was used for comparisons between the CRUSADE and ACUITY scores. Predictors of radial access were compared between the groups. Statistical significance was defined by p < 0,05. Results: Radial access was chosen in 67% of 347 consecutive patients. Patients who underwent radial approach had lower risk of bleeding determined by CRUSADE (30 ± 14 vs. 37 ± 15; p < 0.001) as compared with femoral access. In multivariate analysis, four variables were identified as independent predictors negatively associated with radial access - age (OR = 0.98; 95%CI = 0.96 - 0.99), creatinine (OR = 0.54; 95%CI = 0.3 - 0.98), signs of left ventricular failure (OR = 0.45; 95% CI = 0.22 - 0.92) and previous CABG (OR = 0.022; 95%CI = 0.003 - 0.166). Conclusion: The propensity to choose radial over femoral access in coronary intervention was not primarily influenced by patients’ bleeding risk. Predictors of this decision, identified in the study, indicated less complex patients, suggesting that the difficulty in performing the technique was a stronger determinant than its potential antihemorrhagic effect. (Int J Cardiovasc Sci. 2018; [online].ahead print, PP.0-0)

https://doi.org/10.5935/2359-4802.20180066 519 downloads

What do Cochrane systematic reviews say about new practices on integrative medicine?
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Riera, Rachel

; Braga, Vinícius Lopes

; Rocha, Luana Pompeu dos Santos

; Bernardo, Daniel Damasceno

; Andrade, Luísa Avelar Fernandes de

; Hsu, Jessica Chiu

; Silva, Luciana Di Giovanni Marques da

; Suetsugu, Rodrigo Cesar de Sá

; Dittrich, Nicole Hosni

; Lima, Lucas Riguete Pereira de

; Silveira, Vicente Penido da

; Kruglensky, Barbara Caon

; Leonel, Letícia de Freitas

; Barros, Edivando de Moura

; Costa, Anderson Adriano Leal Freitas da

; Quintella, Miguel Lins

; Pacheco, Rafael Leite

; Cruz, Carolina de Oliveira

; Martimbianco, Ana Luiza Cabrera

; Pachito, Daniela Vianna

; Mozetic, Vania

; Teixeira, Tatiana de Bruyn Ferraz

; Torloni, Maria Regina

; Atallah, Alvaro Nagib

Sao Paulo Medical Journal

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may 2018, Volume 136 N. 3 Pages 251 - 261

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: This study identified and summarized all Cochrane systematic reviews (SRs) on the effects of ten integrative practices that were recently added to the Brazilian public healthcare system (SUS). DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp). METHODS: Review of Cochrane SRs on the following interventions were identified, summarized and critically assessed: apitherapy, aromatherapy, bioenergetics, family constellation, flower therapy, chromotherapy, geotherapy, hypnotherapy, hand imposition or ozone therapy. RESULTS: We included a total of 16 SRs: 4 on apitherapy, 4 on aromatherapy, 6 on hypnotherapy and 2 on ozone therapy. No Cochrane SR was found regarding bioenergetics, family constellation, chromotherapy, clay therapy, flower therapy or hand imposition. The only high-quality evidence was in relation to the potential benefit of apitherapy, specifically regarding some benefits from honey dressings for partial healing of burn wounds, for reduction of coughing among children with acute coughs and for preventing allergic reactions to insect stings. CONCLUSION: Except for some specific uses of apitherapy (honey for burn wounds and for acute coughs and bee venom for allergic reactions to insect stings), the use of ten integrative practices that have recently been incorporated into SUS does not seem to be supported by evidence from Cochrane SRs.

https://doi.org/10.1590/1516-3180.2018.0172170418 2326 downloads

10.

Evaluation of Endothelial Function in Pre-Menopausal Women with Coronary Arterial Disease
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Farias, Wilma Karlla dos Santos

; Rocha, Tania Pavão Oliveira

; Melo, Jorgileia Braga de

; Fonseca, Erika Joseth Nogueira da Cruz

; Fernandes, Darci Ramos

; Pontes, Leticia Prince

; Andrade, Maria Valneide Gomes

; Figueiredo Neto, José Albuquerque de

International Journal of Cardiovascular Sciences

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jun 2017, Volume 30 N. 3 Pages 227 - 234

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamentos: O endotélio desempenha importante função reguladora vascular. Sua disfunção é um marcador precoce de risco cardiovascular. Entretanto, existem poucos estudos em nosso meio que avaliem a função endotelial em mulheres climatéricas. Objetivo: Avaliar a função endotelial em mulheres climatéricas na presença ou ausência de doença arterial coronariana utilizando-se um método biofísico (espessura médio-intimal das carótidas) e um método bioquímico (níveis séricos de PCR-US). Métodos: Estudo transversal que avaliou o espessamento médio-intimal da artéria carótida e níveis séricos de PCR-US de 31 mulheres climatéricas submetidas a cineangiocoronariografia, no Serviço de Hemodinâmica do Hospital Universitário da Universidade Federal do Maranhão, no período de março de 2012 a julho de 2013. Os dados foram submetidos à análise estatística. Considerou-se um nível de significância de 5%. Resultados: A amostra foi dividida em dois grupos, de acordo com presença de doença arterial coronariana (DAC): grupo com DAC (n = 13) e grupo sem DAC (n = 18). As médias de idades para os grupos foram 57,92 ± 5,17 e 51,72 ± 4,63 anos, respectivamente (p = 0,001). A EMI esteve alterada em 29,03% na população geral. A espessura médio- intimal foi de 1,55 ± 0,78 mm no grupo geral, 1,92 ± 0,94 mm no grupo com DAC e 1,18 ± 0,71 mm no grupo sem DAC (p = 0,001). As pacientes com DAC apresentaram predomínio de alteração da EMI quando comparadas aquelas sem DAC: 36,46% vs. 22,22%, respectivamente. Observou-se uma sensibilidade de 38%, especificidade de 77%, com um valor preditivo positivo de 0,55 e valor preditivo negativo de 0,63 com razão de verossimilhança para teste positivo (likelihood ratio) de 1,73. As pacientes com EMI alterado apresentaram níveis mais elevados de PCR-US, porém sem significância estatística.As pacientes com DAC apresentaram níveis mais elevados de PCR-US, porém sem significância estatística. Conclusão: Na população estudada, a avaliação da função endotelial pelo método da EMI apresentou maior sensibilidade e especificidade para o diagnóstico de DAC quando comparada a mensuração dos níveis de PCR-US em mulheres climatéricas.

Abstract Background: The endothelium plays an important vascular regulatory function. Its dysfunction is an early marker of cardiovascular risk. However, there are few studies in our community that assess endothelial function in pre-menopausal women. Objective: To assess endothelial function in pre-menopausal women in the presence or absence of coronary artery disease, using a biophysical method (carotid intima media thickness) and a biochemical method (serum levels of hsCRP). Methods: Cross-sectional study that evaluated carotid intima-media thickness and serum levels of hsCRP of 31 pre-menopausal women undergoing coronary angiography at the Hemodynamics Service of Hospital Universitário da Universidade Federal do Maranhão from March 2012 to July 2013. The data were sent to statistical analysis and a statistical significance level of 5% was considered. Results: The sample was divided into two groups according to the presence of coronary artery disease (CAD): CAD group (n = 13) and group without CAD (n = 18). The average ages for the groups were 57.92 ± 5.17 and 51.72 ± 4.63 years, respectively (p = 0.001). CIMT was abnormal in 29.03% in the general population. Carotid intima-media thickness was 1.55 ± 0.78 mm in the general group, 1.92 ± 0.94 mm in the CAD group and 1.18 ± 0.71 mm in the group without CAD (p = 0.001). CAD patients had predominance of abnormal CMIT compared those without CAD: 36.46% vs. 22.22%, respectively. There was a sensitivity of 38%, specificity of 77% with a positive predictive value of 0.55 and a negative predictive value of 0.63 with likelihood ratio of 1.73. Patients with abnormal CIMT presented higher levels of hsCRP, but without statistical significance. CAD patients had higher levels of hsCRP, but without statistical significance. Conclusion: In the population studied, assessment of endothelial function using the CIMT method showed higher sensitivity and specificity for the diagnosis of CAD compared to the measurement of hsCRP levels in menopausal women.

https://doi.org/10.5935/2359-4802.20170043 1803 downloads

11.

Poor sensitivity of rapid tests for the detection of antibodies to the hepatitis B virus: implications for field studies
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Cruz, Helena Medina

; Scalioni, Leticia de Paula

; Paula, Vanessa Salete de

; Miguel, Juliana Custódio

; Ó, Kycia Maria Rodrigues do

; Milagres, Flavio Augusto Pádua

; Cruz, Marcelo Santos

; Bastos, Francisco Inácio

; Flores, Priscila Pollo

; Leal, Erotildes

; Motta-Castro, Ana Rita Coimbra

; Lewis-Ximenez, Lia Laura

; Lampe, Elisabeth

; Villar, Livia Melo

Memórias do Instituto Oswaldo Cruz

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mar 2017, Volume 112 N. 3 Pages 209 - 213

Abstract: En | Text: En | PDF: En

Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups. The sensitivity values to anti-HBs were 50.38%, 51.05% and 46.73% and the sensitivity values to anti-HBe were 76.99%, 10.34% and 11.76% in the GI, GII and GIII groups, respectively. The assays had a low sensitivity and high specificity, which indicated their use for screening in regions endemic for HBV.

https://doi.org/10.1590/0074-02760160394 2044 downloads

12.

Relationship between viral load and behavioral measures of adherence to antiretroviral therapy in children living with human immunodeficiency virus in Latin America
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Duarte, Horacio A.

; Harris, Donald Robert

; Tassiopoulos, Katherine

; Leister, Erin

; Negrini, Silvia Fabiana Biason de Moura

; Ferreira, Flávia Faleiro

; Cruz, Maria Letícia Santos

; Pinto, Jorge

; Allison, Susannah

; Hazra, Rohan

Brazilian Journal of Infectious Diseases

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jun 2015, Volume 19 N. 3 Pages 263 - 271

Abstract: En | Text: En | PDF: En

Few studies have examined antiretroviral therapy adherence in Latin American children. Standardized behavioral measures were applied to a large cohort of human immunodeficiency virus-infected children in Brazil, Mexico, and Peru to assess adherence to prescribed antiretroviral therapy doses during the three days prior to study visits, assess timing of last missed dose, and evaluate the ability of the adherence measures to predict viral suppression. Time trends in adherence were modeled using a generalized estimating equations approach to account for possible correlations in outcomes measured repeatedly in the same participants. Associations of adherence with human immunodeficiency virus viral load were examined using linear regression. Mean enrollment age of the 380 participants was 5 years; 57.6% had undetectable' viral load (<400 copies/mL). At enrollment, 90.8% of participants were perfectly (100%) adherent, compared to 87.6% at the 6-month and 92.0% at the 12-month visit; the proportion with perfect adherence did not differ over time (p= 0.1). Perfect adherence was associated with a higher probability of undetectable viral load at the 12-month visit (odds ratio = 4.1, 95% confidence interval: 1.8-9.1; p< 0.001), but not at enrollment or the 6-month visit (p> 0.3). Last time missed any antiretroviral therapy dose was reported as "never" for 52.0% at enrollment, increasing to 60.7% and 65.9% at the 6- and 12-month visits, respectively (p< 0.001 for test of trend). The proportion with undetectable viral load was higher among those who never missed a dose at enrollment and the 12-month visit (p≤ 0.005), but not at the 6-month visit (p= 0.2). While antiretroviral therapy adherence measures utilized in this study showed some association with viral load for these Latin American children, they may not be adequate for reliably identifying non-adherence and consequently children at risk for viral resistance. Other strategies are needed to improve the evaluation of adherence in this population.

https://doi.org/10.1016/j.bjid.2015.01.004 1096 downloads

13.

Vitamin A, vitamin E, iron and zinc status in a cohort of HIV-infected mothers and their uninfected infants
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Monteiro, Jacqueline Pontes

; Cruz, Maria Letícia Santos

; Mussi-Pinhata, Marisa Márcia

; Salomão, Roberta Garcia

; Jordão Junior, Alceu

; Read, Jennifer Suzanne

; Pilotto, José Henrique da Silva

; Cohen, Rachel Ann

; Stoszek, Sonia Karolina

; Siberry, George Kelly

Revista da Sociedade Brasileira de Medicina Tropical

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dec 2014, Volume 47 N. 6 Pages 692 - 700

Abstract: En | Text: En | PDF: En

Introduction We hypothesized that nutritional deficiency would be common in a cohort of postpartum, human immunodeficiency virus (HIV)-infected women and their infants. Methods Weight and height, as well as blood concentrations of retinol, α-tocopherol, ferritin, hemoglobin, and zinc, were measured in mothers after delivery and in their infants at birth and at 6-12 weeks and six months of age. Retinol and α-tocopherol levels were quantified by high performance liquid chromatography, and zinc levels were measured by atomic absorption spectrophotometry. The maternal body mass index during pregnancy was adjusted for gestational age (adjBMI). Results Among the 97 women 19.6% were underweight. Laboratory abnormalities were most frequently observed for the hemoglobin (46.4%), zinc (41.1%), retinol (12.5%) and ferritin (6.5%) levels. Five percent of the women had mean corpuscular hemoglobin concentrations < 31g/dL. The most common deficiency in the infants was α-tocopherol (81%) at birth; however, only 18.5% of infants had deficient levels at six months of age. Large percentages of infants had zinc (36.8%) and retinol (29.5%) deficiencies at birth; however, these percentages decreased to 17.5% and 18.5%, respectively, by six months of age. No associations between infant micronutrient deficiencies and either the maternal adjBMI category or maternal micronutrient deficiencies were found. Conclusions Micronutrient deficiencies were common in HIV-infected women and their infants. Micronutrient deficiencies were less prevalent in the infants at six months of age. Neither underweight women nor their infants at birth were at increased risk for micronutrient deficiencies.

https://doi.org/10.1590/0037-8682-0226-2014 2641 downloads

14.

Congenital toxoplasmosis infection in an infant born to an HIV-1-infected mother
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Cruz, Maria Letícia Santos

; Cardoso, Claudete Araújo

; Saavedra, Mariza C.

; Santos, Eliane dos

; Melino, Tatiana

Brazilian Journal of Infectious Diseases

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dec 2007, Volume 11 N. 6 Pages 610 - 611

Abstract: En | Text: En | PDF: En

We report the occurrence of congenital toxoplasmosis in an infant born to an HIV infected mother who had high anti-toxoplasma IgG and negative IgM at nine weeks of gestation. We briefly review available literature and discuss the possible mechanisms of transmission of congenital toxoplasmosis among HIV infected pregnant women.

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15.

Trends in a Cohort of HIV-infected pregnant women in Rio de Janeiro, 1996-2004
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Calvet, Guilherme Amaral

; João, Esaú Custódio

; Nielsen-Saines, Karin

; Cunha, Cynthia Braga

; Menezes, Jacqueline Anita

; d'Ippolito, Marcos Machado

; Cruz, Maria Letícia Santos

; Martins, Ezequias Batista

; Silva, Sônia Maria Santos

; Medeiros, Adriana Ferreira

; Matos, Haroldo José

Revista Brasileira de Epidemiologia

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sep 2007, Volume 10 N. 3 Pages 323 - 337

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

OBJETIVOS: Descrever as tendências temporais nas características sociodemográficas, imunológicas e virológicas e as das condutas utilizadas para reduzir o risco da transmissão mãe-filho do HIV. MÉTODOS: Estudo de coorte retrospectivo em uma instituição de saúde terciária no Rio de Janeiro de janeiro de 1996 a dezembro de 2004. A análise utilizou a estratificação em três períodos de tempo: 1996-1998 (P1), 1999-2001 (P2) e 2002-2004 (P3). RESULTADOS: Em 9 anos, 622 gestações foram acompanhadas. As complicações foram: mortalidade materna 0,3%, natimortos 2,5%, abortos 0,6%, mortalidade neonatal 1,1%, prematuridade 9,9%, baixo peso ao nascer (BPN) 16,5%, malformações congênitas 2,2%. O número de gestantes HIV positivo triplicou ao longo do tempo, refletindo o aumento da prevalência da doença e a melhor identificação das pacientes. O diagnóstico da infecção pelo HIV antes da gestação aumentou de 30% em P1 para 45% em P3. A proporção de gestantes recebendo o tratamento combinado potente aumentou de zero em P1 para 88% em P3 com uma tendência significativa a ter uma carga viral abaixo do limite de detecção no parto nos últimos anos apesar de uma maior proporção de pacientes com doença mais avançada. O índice de cesarianas eletivas aumentou de 35% em P1 para 48% em P3. A taxa de transmissão perinatal global foi de 2,4% caindo de 3,5% em P1 para 1,6% em P3. Os desfechos neonatais tenderam a permanecer constantes ou a melhorar ao longo do tempo. Um discreto aumento dos índices de BPN e de malformações congênitas foi observado. CONCLUSÕES: Ao longo do período de estudo aumentou a proporção de gestantes HIV positivo com doença mais avançada e com padrão socioeconômico mais baixo. Por outro lado, a melhora da abordagem terapêutica dos pacientes infectados pelo HIV, associada a uma maior detecção de casos e maior acesso ao tratamento, resultou em uma redução da taxa de transmissão igualando-se à observada em países desenvolvidos com melhora concomitante de outros desfechos.

OBJECTIVE: To describe trends in sociodemographic, immunological and virological profiles and interventions to decrease the risk of mother-to-child HIV transmission. METHODS: Retrospective cohort study conducted at a tertiary institution in Rio de Janeiro, Brazil from January 1996 to December 2004. Analysis was performed by stratification in three time periods: 1996-1998 (P1), 1999-2001 (P2) and 2002-2004 (P3). RESULTS: In 9 years, 622 pregnancies occurred. Complications included: maternal mortality 0.3%, stillbirths 2.5%, miscarriages 0.6%, neonatal mortality 1.1%, prematurity 9.9%, low birth weight (LBW) 16.5%, congenital malformations 2.2%. The number of HIV-infected pregnant patients grew threefold over time reflecting increased prevalence of disease and patient identification. HIV diagnosis before pregnancy increased from 30% in P1 to 45% in P3. The proportion of pregnant women receiving highly active antiretroviral therapy increased from none (P1) to 88% (P3) with a significant trend towards women delivering at undetectable viral loads in later years despite a higher frequency of advanced disease. Scheduled cesarean deliveries increased from 35% in P1 to 48% in P3. Perinatal transmission rates were 2.4% with a decline from 3.5% in P1 to 1.6% in P3. Neonatal outcomes tended to remain constant or improve with time. A slight rise in LBW and congenital malformations were observed. CONCLUSIONS: During the observational period, HIV+ pregnant women presented with more advanced disease and lower socio-economic status. However, improved management of HIV-infected patients (associated with increased identification and increased availability of treatment) resulted into very low transmission rates similar to those of developed countries with overall improvement of patient outcomes.

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