ABSTRACT OBJECTIVE This study aimed to investigate the effect of mouthwash use on the development of oral cancer. METHODS Observational studies with adult/older adult populations that have examined the association between mouthwash use and oral cancer were included. Electronic search was performed in July 2022, with no time or language restrictions. PubMed/Medline, Embase, and Web of Science databases were used, and the search was extended to theses and dissertations libraries, Google Scholar, reference lists, and other sources. Methodological quality was assessed using the Newcastle-Ottawa Scale and quantitative data synthesis was performed by random effects meta-analysis, with different subgroup analyses and meta-regression. This revision was registered in Prospero (CRD42020143307). RESULTS Of the 4,094 studies identified in the search, 15 case-control studies were included in the review, totaling 6,515 cases and 17,037 controls. The meta-analysis included 17 measures of effect from 15 case-control studies. The pooled OR was 1.00 (95%CI: 0.79–1.26, n = 17 studies), but it was 2.58 (95%CI: 1.38–4.82, n = 2 studies) among those who had used mouthwashes three times or more times a day, and 1.30 (95%CI: 1.10–1.54, n = 4 studies) among those who had used mouthwashes for more than 40 years. CONCLUSIONS We found evidence that a high frequency of mouthwash use may be associated with an increased risk of oral cancer. However, despite the biological plausibility for this association, we suggest caution upon interpretation of our findings due to the few number of studies that have investigated the mouthwash use frequency, which should be considered. Therefore, we recommend that future studies assess, in detail, the frequency, duration, and content of mouthwashes to increase the strength of evidence for a possible dose-response effect of mouthwashes on oral cancer risk. adultolder older 2022 restrictions PubMedMedline PubMed Medline PubMed/Medline Embase libraries Scholar lists sources NewcastleOttawa Newcastle Ottawa metaanalysis, metaanalysis meta analysis, analysis metaregression. metaregression regression. regression meta-regression CRD42020143307. CRD42020143307 CRD . (CRD42020143307) 4094 094 4,09 1 casecontrol case control review 6515 6 515 6,51 17037 037 17,03 controls 100 00 1.0 95%CI 95CI CI 95 (95%CI 079126 0 79 26 0.79–1.26 studies, , 258 58 2.5 138482 38 82 1.38–4.82 day 130 30 1.3 110154 10 54 1.10–1.54 years However considered Therefore assess detail duration doseresponse dose response 202 CRD4202014330 (CRD42020143307 409 09 4,0 651 51 6,5 1703 03 17,0 1. 9 07912 7 0.79–1.2 25 5 2. 13848 3 8 1.38–4.8 13 11015 1.10–1.5 20 CRD420201433 (CRD4202014330 4, 65 6, 170 17, 0791 0.79–1. 1384 1.38–4. 1101 1.10–1. CRD42020143 (CRD420201433 079 0.79–1 138 1.38–4 110 1.10–1 CRD4202014 (CRD42020143 07 0.79– 1.38– 11 1.10– CRD420201 (CRD4202014 0.79 1.38 1.10 CRD42020 (CRD420201 0.7 1.1 CRD4202 (CRD42020 0. CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

ABSTRACT OBJECTIVE This study aimed to investigate the effect of mouthwash use on the development of oral cancer. METHODS Observational studies with adult/older adult populations that have examined the association between mouthwash use and oral cancer were included. Electronic search was performed in July 2022, with no time or language restrictions. PubMed/Medline, Embase, and Web of Science databases were used, and the search was extended to theses and dissertations libraries, Google Scholar, reference lists, and other sources. Methodological quality was assessed using the Newcastle-Ottawa Scale and quantitative data synthesis was performed by random effects meta-analysis, with different subgroup analyses and meta-regression. This revision was registered in Prospero (CRD42020143307). RESULTS Of the 4,094 studies identified in the search, 15 case-control studies were included in the review, totaling 6,515 cases and 17,037 controls. The meta-analysis included 17 measures of effect from 15 case-control studies. The pooled OR was 1.00 (95%CI: 0.79–1.26, n = 17 studies), but it was 2.58 (95%CI: 1.38–4.82, n = 2 studies) among those who had used mouthwashes three times or more times a day, and 1.30 (95%CI: 1.10–1.54, n = 4 studies) among those who had used mouthwashes for more than 40 years. CONCLUSIONS We found evidence that a high frequency of mouthwash use may be associated with an increased risk of oral cancer. However, despite the biological plausibility for this association, we suggest caution upon interpretation of our findings due to the few number of studies that have investigated the mouthwash use frequency, which should be considered. Therefore, we recommend that future studies assess, in detail, the frequency, duration, and content of mouthwashes to increase the strength of evidence for a possible dose-response effect of mouthwashes on oral cancer risk.

INTRODUÇÃO: O câncer oral é uma doença multifatorial com alta incidência no mundo, que vem sendo considerado problema de saúde pública, sendo a prevenção e o diagnóstico precoce as melhores formas de reverter essa situação. OBJETIVO: Avaliar o nível de conhecimento sobre o câncer oral em uma população de estudantes de odontologia. MÉTODO: Um questionário sobre o câncer de boca foi aplicado a 150 alunos de seis turmas, divididos em três grupos de acordo com o semestre letivo. As variáveis estudadas foram analisadas estatisticamente aplicando-se o teste do Qui-quadrado com intervalo de confiança de 95%, e nível de significância de 5%. RESULTADO: Oitenta e oito alunos (60,61%) consideraram seu nível de conhecimento sobre câncer oral bom ou regular, enquanto 37,93% avaliaram seu conhecimento como insuficiente. O carcinoma espinocelular foi considerado o câncer mais comum por apenas 38,25% do total de estudantes, sendo o percentual maior de acerto para os grupos 2 (55,56%) e 3 (67,39%). O nível de conhecimento sobre os fatores de risco aumentou ao longo dos semestres, entretanto, 77,85% consideram baixo o seu nível de confiança para realizar procedimentos de diagnóstico. CONCLUSÃO: O nível de conhecimento sobre câncer oral foi considerado bom ou regular entre os estudantes de odontologia entrevistados; apesar de demonstrarem um bom nível de conhecimento em relação aos fatores de risco e a questões específicas da doença, ficou clara a necessidade de implementar medidas educativas continuadas ao longo do curso de forma a consolidar o ensino sobre essa patologia.

INTRODUCTION: Oral cancer is a multifactorial disease of high incidence worldwide and considered a public health problem, in which prevention and early diagnosis are the best ways to reverse this situation. PURPOSE: To evaluate the level of knowledge on oral cancer in a population of dentistry students. METHOD: A questionnaire on oral cancer was applied to 150 students from six classes, divided into three groups according to their semesters. The variables studied were statistically analyzed by applying the chi-square test with confidence interval of 95% and significance level of 5%. RESULT: Eighty-eight students (60.61%) considered their level of knowledge on oral cancer good and regular, while 37.93% rated their knowledge as insufficient. Squamous cell carcinoma was listed as the most common cancer by only 38.25% of students, with the highest percentage of correct answers being observed for groups 2 (55.56%) and 3 (67.39%). The level of knowledge on the risk factors increased over the semesters; however, 77.85% considered their level of confidence to perform diagnostic procedures low. CONCLUSION: The level of knowledge on oral cancer was considered good or regular among dentistry students, and although they showed good level of knowledge on the risk factors and to specific issues of the disease, there is a clear need to implement continued educational measures throughout the course to consolidate learning on this disease.

AIM: To evaluate the effects of radioiodine therapy on salivary flow in patients with differentiated thyroid cancer. METHODS: A sample comprising 88 patients submitted to ablation with iodine 131 was included in the study. The patients were submitted to sialometry and evaluation of the presence of xerostomia before, 10 days and 3 months after radioiodine therapy. RESULTS: Xerostomia was observed in 36.4% of the patients before radioiodine therapy, 59.15% at 10 days after therapy, and 25% at 3 months after therapy. Significant differences were observed in non-stimulated salivary flow rates between the second and third evaluations (p<0.020) and in stimulated salivary flow between the first and second evaluations (p<0.010). CONCLUSIONS: The results suggest that changes in salivary flow resulting from radioiodine therapy are more pronounced during the first weeks after treatment and seem to regress after 3 months.

FUNDAMENTOS: As doenças dermatológicas não estão representadas apenas pelas lesões que afetam a pele, mas, também, por manifestações que podem envolver as mucosas, inclusive a mucosa oral. OBJETIVOS: Avaliar a frequência das manifestações orais em pacientes com doenças dermatológicas, considerando-se a localização e as características clínicas das lesões encontradas, o sexo, a idade e a raça dos acometidos. MÉTODOS: Estudo observacional, do tipo transversal, com pacientes que procuraram atendimento no Serviço de Dermatologia do Hospital Universitário Presidente Dutra (HUPD) da Universidade Federal do Maranhão (UFMA) entre outubro de 2007 e outubro de 2008 (n=88). RESULTADOS: A idade variou entre cinco e 88 anos, e o sexo feminino foi o mais atingido (2:1). Dos casos examinados, 35% eram de líquen plano, 33% de lúpus eritematoso, 24% de eritema multiforme, 7% de pênfigo vulgar e 1% do grupo penfigoide. As lesões orais foram mais frequentes nos portadores de líquen plano (51%) e lúpus eritematoso (20%). O líquen plano reticular foi a forma clínica mais comum e a mucosa jugal, o sítio mais acometido. CONCLUSÕES: O conhecimento dessas patologias pelo cirurgião-dentista é de fundamental importância, cabendo-lhe uma parcela de responsabilidade pelo diagnóstico precoce e orientação para o tratamento adequado. Além disso, o exame intraoral deve ser incorporado como prática de rotina durante o atendimento dermatológico.

BACKGROUND: Dermatologic diseases are not only represented by lesions affecting the skin but also by manifestations that may involve the mucous membranes, including oral mucosa. OBJECTIVES: To evaluate the frequency of oral manifestations associated with dermatologic diseases considering location and clinical characteristics of the lesions found and also gender, age and race of patients. METHOD: It was an observational, cross-sectional study of patients who sought for treatment at the Dermatology Service of the University Hospital (Hospital Presidente Dutra-HUPD); UFMA, between October 2007 and October 2008 (n=88). RESULTS: Age varied from 5 to 88 and there was predominance of female patients. 35% of the cases studied were diagnosed as lichen planus; 33% as lupus erythematosus; 24% as erythema multiforme; 7% as pemphigus vulgaris and 1% as pemphigoid group. Oral manifestations were more common among patients suffering from lichen pplanus (51%) and lupus erythematosus (20%). The most common clinical presentation found was reticular lichen planus located most predominantly in the buccal mucosa. CONCLUSIONS: It is essential that dentists know these pathologies to be able to diagnose them in an early stage of the disease and to direct patients to adequate treatment. Furthermore, intraoral examination should be included as a routine practice in dermatological services.

INTRODUÇÃO E OBJETIVO: As neoplasias de glândulas salivares constituem um grupo de lesões, clínica e morfologicamente diverso, capaz de determinar importantes desafios diagnósticos e terapêuticos. O escopo do trabalho é determinar a frequência relativa e a distribuição das neoplasias de glândulas salivares diagnosticadas no Instituto Maranhense de Oncologia Aldenora Bello (IMOAB). MATERIAL E MÉTODOS: Realizou-se estudo retrospectivo dos casos de neoplasia de glândula salivar diagnosticados no IMOAB, no período de janeiro de 1997 a dezembro de 2007. Dados sobre sexo, idade e localização anatômica foram obtidos em prontuários médicos. Cortes histológicos foram avaliados sob microscopia de luz e os casos foram categorizados segundo a classificação da Organização Mundial da Saúde (OMS)(4). Os dados coletados foram analisados por meio de estatística descritiva. RESULTADOS: Foram identificados 232 casos, dos quais 178 eram neoplasias benignas (76,7%) e 54 (23,3%), malignas. Os três tipos histológicos mais frequentes foram: adenoma pleomórfico (59,5%), tumor de Warthin (13,8%) e carcinoma adenoide cístico (6,9%). A maioria dos casos foi diagnosticada em pacientes do sexo feminino, com proporção homem:mulher de 1:1,3. As neoplasias benignas e malignas apresentaram picos de incidência na quarta e sétima décadas de vida, respectivamente. Com relação à localização anatômica, 154 casos (66,4%) afetaram a parótida, 43 (18,5%) acometeram a glândula submandibular e 35 (15,1%) envolveram glândulas salivares menores. CONCLUSÃO: Em conjunto com outros estudos, os resultados da presente pesquisa sugerem discretas variações na frequência relativa e distribuição das neoplasias de glândulas salivares entre as populações do Brasil e de outras regiões do mundo.

INTRODUCTION AND OBJECTIVE: The salivary gland neoplasms are a clinically and morphologically diverse group of lesions able to determine important diagnostic and therapeutic challenges. The objective of this study is to determine the relative frequency and distribution of salivary gland neoplasms diagnosed at Aldenora Bello Institute of Oncology - Maranhão State (Instituto Maranhense de Oncologia Aldenora Bello [IMOAB]). MATERIAL AND METHODS: It was performed a retrospective analysis of the salivary gland neoplasms diagnosed at IMOAB between January 1997 and December 2007. Data regarding gender, age, and anatomic site were retrieved from medical records. Histological slides were evaluated by light microscopy and cases were categorized according to the World Health Organization classification(4). The collected data were analyzed through descriptive statistics. RESULTS: A total of 232 cases were identified, of which 178 were benign neoplasms (76.7%) and 54 (23.3%) were malignant. The three most frequent histological types were pleomorphic adenoma (59.5%), Warthin's tumor (13.8%) and adenoid cystic carcinoma (6.9%). Most cases were diagnosed in females, with a male-female ratio of 1:1.3. The benign and malignant neoplasms showed incidence peaks at the 4th and 7th decades of life, respectively. Regarding anatomic site, 154 cases (66.4 %) affected the parotid gland, 43 (18.5%) affected the submandibular gland and 35 (15.1%) involved minor salivary glands. CONCLUSION: In association with other studies, the present results suggest slight variations in the relative frequency and distribution of salivary gland neoplasms between Brazilian and worldwide populations.

Este estudo analisou a expressão imuno-histoquímica de E-caderina e CD44v6 em 15 carcinomas de células escamosas (CCEs) de lábio inferior e em 15 CCEs de língua, com o intuito de identificar possíveis associações entre a expressão destas proteínas e a localização anatômica da lesão, ocorrência de metástase nodal e gradação histológica de malignidade. Foram avaliados o padrão de expressão e o número de células imunopositivas. Os resultados foram analisados pelo teste exato de Fisher, teste de Mann-Withney e coeficiente de correlação de Spearman (r), utilizando o software SPSS 10.0 para Windows. Para todos os testes, a significância estatística foi determinada em 5%, para um valor de p<0,05. Os resultados revelaram não haver diferença significativa no padrão de expressão e na quantidade de células imunopositivas para E-caderina e CD44v6 em relação à localização anatômica e metástase nodal (p>0,05). Para a gradação histológica de malignidade, os CCEs de baixo escore revelaram maior imunopositividade para E-caderina e CD44v6, tanto para o padrão de expressão quanto para o número de células imunopositivas (p<0,05). Observou-se correlação negativa entre o escore total de malignidade e o padrão de expressão e a quantidade de células imunopositivas para E-caderina e CD44v6 (p<0,05). Em conclusão, CCEs de lábio inferior e língua não revelaram diferenças significativas na expressão de E-caderina e CD44v6. A expressão destas moléculas de adesão revelou associação apenas com gradação histológica de malignidade dos CCEs. Dessa forma, os resultados sugerem que E-caderina e CD44v6 podem não ser capazes de elucidar as diferenças existentes no comportamento biológico de CCEs de lábio inferior e língua.

This study analyzed the immunohistochemical expression of E-cadherin and CD44v6 in 15 squamous cell carcinomas (SCCs) of lower lip and 15 SCCs of tongue in order to verify a possible association between these proteins and the anatomic location of the lesion, nodal metastasis and histological grading of malignancy. The pattern of expression and number of immunopositive cells were evaluated. The results were analyzed with the Fisher's exact test, Mann-Whitney test and Spearman's Correlation Coefficient (r). using the SPSS software 10.0 for Windows. Statistical significance was set at 5% determined for a p-value<0.05 for all tests. There was no significant difference (p>0.05) in the pattern of expression and number of immunopositive cells for E-cadherin and CD44v6, regarding the anatomical location and nodal metastasis. For the histological grading, low score SCCs showed higher immunopositivity for E-cadherin and CD44v6, both for the pattern of expression and number of immunopositive cells (p<0.05). There was a negative correlation between the total score of malignancy and the pattern of expression and number of immunopositive cells for E-cadherin and CD44v6 (p<0.05). In conclusion, SCCs of the lower lip and tongue did not reveal significant differences in the expression of E-cadherin and CD44v6. The expression of these adhesion molecules revealed association only with tumor histological grading of malignancy. Therefore, these results suggest that E-cadherin and CD44v6 may not help elucidating the differences between the biological behavior of SCCs of the lower lip and tongue.

O objetivo deste estudo foi investigar a existência de correlação entre os dados clínicos e histopatológicos do carcinoma espinocelular oral. Foram avaliados 90 casos de pacientes com diagnóstico de carcinoma espinocelular oral dos arquivos do Instituto Maranhense de Oncologia Aldenora Bello (IMOAB) (São Luís, MA). Aplicou-se o teste de correlação de Pearson, em nível de significância de 5%, não tendo sido revelada relação estatisticamente significante (r = 0,095, p = 0,375) entre a classificação clínica TNM (tumor, linfonodo, metástase) e a graduação histológica de malignidade (GHM) desenvolvida por Wahi (1971) e publicada pela Organização Mundial da Saúde (OMS). Mas houve relação significativa entre a referida graduação histológica de malignidade e o parâmetro clínico tamanho do tumor primário (T) (r = 0,229, p = 0,03).

The aim of this study was to investigate the existence of correlation between the clinical and histopathological data of oral squamous cell carcinoma. A total of 90 cases of patients diagnosed with oral squamous cell carcinoma were selected from the slide archives of Instituto Maranhense de Oncologia Aldenora Bello (São Luís, MA, Brazil). Pearson’s correlation test was applied and did not reveal a statistically significant correlation (r = 0.095; p = 0.375) between TNM clinical classification and histologic malignancy grading, which was defined by Wahi (1971) and published by the World Health Organization (WHO). There was a significant correlation between the histologic malignancy grading and the size of the primary tumor as a clinical parameter (r = 0.229; p = 0.03).

OBJETIVO: O presente trabalho teve por objetivo traçar o perfil das citoqueratinas (CKs) 7, 8, 10, 13, 14, 18 e 19 em ameloblastomas e tumor odontogênico adenomatóide (TOA) visando contribuir para o entendimento da histogênese desses tumores e somar com os resultados já relatados na literatura. MATERIAL E MÉTODO: do arquivo do Laboratório de Anatomia Patológica do Departamento de Odontologia da Universidade Federal do Rio Grande do Norte (UFRN) foi selecionada uma amostra com dez casos de ameloblastomas e oito de TOA para o estudo imuno-histoquímico, utilizando-se anticorpos anti-CKs pelo método da estreptoavidina-biotina. RESULTADOS: Observou-se que nos ameloblastomas a CK 14 esteve presente em todos os casos, enquanto a CK 19 foi observada nas células periféricas (oito casos) e nas centrais (cinco casos). Para os TOA, observou-se imunopositividade para a CK 14 em todos os casos, enquanto a CK 19 esteve marcada predominantemente nas células ductais (seis casos). CONCLUSÃO: As citoqueratinas são expressas de forma variada nos ameloblastomas e nos TOA, os quais preservam CK típicas do germe dental em estágios avançados do desenvolvimento, confirmando sua origem exclusiva a partir do epitélio odontogênico e não se evidenciando CK características do epitélio escamoso.

OBJECTIVES: The aim of the present study was to describe the immunohistochemical expression of cytokeratins (CKs) 7, 8, 10,13, 14, 18 and 19 in the epithelial components of ameloblastomas and adenomatoid odontogenic tumor (AOT). The results were compared and histogenesis discussed. MATERIAL AND METHOD: Specimens of ten ameloblastomas and eight adenomatoid odontogenic tumors were examined by immunohistochemistry using streptavidin-biotin-peroxidase complex method and anti-CKs antibody. The sample was obtained from Department of Oral Pathology, Federal University of Rio Grande do Norte. RESULTS: Immunohistochemical reactivity for CK14 was detected in all cases of ameloblastomas, and the expression of CK19 was diffusely present in peripheral cells (eight cases) and in central cells of five ameloblastomas. In AOTs, immunopositivity for CK14 was detected in all cases, whereas CK 19 was predominantly expressed in ductal cells (six cases). CONCLUSION: The CKs was expressed by several forms in ameloblastomas and AOTs, that have shown typical CKs of dental germ suggesting that these tumors have odontogenic epitheilial differentiation, whereas it has not evinced proper CKs of squamous epithelial.

OBJETIVOS: verificar as condições periodontais e necessidade de tratamento fornecidas pelo Registro Periodontal Simplificado (PSR) em puérperas, com o intuito de contribuir ao esclarecimento da relação entre doença periodontal e nascimento de recém-nascidos prematuros de baixo peso. MÉTODOS: foi empregado o PSR em amostra de 40 puérperas, divididas em: grupo 1 (teste), composto pelas mães de recém-nascidos prematuros com peso inferior a 2.500 g (n=20), e grupo 2 (controle), formado por mães de recém-nascidos a termo com peso igual ou superior a 2.500 g (n=20). Os dados coletados foram analisados por meio de estatística descritiva, sendo os resultados do PSR submetidos ao tratamento estatístico para verificar se existem diferenças na condição periodontal e necessidade de tratamento entre as puérperas, sendo empregado o teste de Kolmogorov-Smirnov, em nível de significância de 5%. RESULTADOS: a presença de bolsa periodontal de 3,5 a 5,5 mm foi o achado mais comum entre as puérperas de recém-nascidos de baixo peso (39,17% dos sextantes), ao passo que a presença de sangramento à sondagem e ausência de bolsa periodontal foram os achados mais freqüentes entre as puérperas de recém-nascidos com peso normal (37,50% dos sextantes), havendo diferença significativa na condição periodontal das puérperas (p=0,0494). Quanto à necessidade de tratamento, não houve diferença significativa entre os grupos estudados (p>0,05). CONCLUSÕES: as puérperas de recém-nascidos prematuros com baixo peso apresentaram piores condições periodontais, sugerindo que a infecção periodontal pode estar relacionada ao nascimento de recém-nascidos prematuros de baixo peso.

PURPOSE: to evaluate periodontal conditions and need for treatment supplied by Periodontal Screening and Recording (PSR) in mothers, in order to clarify the relationship between periodontal disease and low birth weight premature newborns. METHODS: PSR was used in a sample of 40 mothers, divided into: test group, consisting of mothers of premature newborns with weight less than 2,500 g (n=20), and the control group, consisting of mothers of term newborns with a weight equal to or over 2,500 g (n=20). The collected data were analyzed by descriptive statistics, and the results of PSR were submitted to statistical analysis in order to verify differences in periodontal condition and need for treatment of the mothers, using the Kolmogorov-Smirnov test, with a significance level of 5%. RESULTS: the presence of periodontal pocket of 3.5 to 5.5 mm was the most common finding among the mothers of newborns with low weight (39.2% of the cases), while the presence of bleeding at probing and absence of a periodontal pocket were the most frequent findings among the mothers of newborns with normal weight (37.5% of the cases). There was a statistically significant difference between periodontal conditions of the mothers of the groups (p=0.0494), but in relation to the need for treatment, there was no significant difference between the studied groups (p>0.05). CONCLUSION: the mothers of preterm newborns with low weight presented worse periodontal conditions, suggesting that periodontal infection may be related to preterm low birth weight newborns.