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Targeted saliva metabolomics in Sjogren’s syndrome Sjogrens Sjogren s
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Florezi, Giovanna Piacenza

; Barone, Felippe Pereira

; Izidoro, Mario Augusto

; Soares-Jr, José Maria

; Coutinho-Camillo, Claudia Malheiros

; Lourenço, Silvia Vanessa

Clinics

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2024, Volume 79 elocation 100459

Abstract: En | Text: En | PDF: En

Abstract Objective: Sjögren’s Syndrome (SS) is a chronic inflammatory autoimmune exocrinopathy, and although, the role of metabolism in the autoimmune responses has been discussed in diseases such as lupus erythematosus, rheumatoid arthritis, psoriasis and scleroderma. There is a lack of information regarding the metabolic implications of SS. Considering that the disease affects primarily salivary glands; the aim of this study is to evaluate the metabolic changes in the salivary glands’ microenvironment using a targeted metabolomics approach. Methods: The saliva from 10 patients diagnosed with SS by the American-European consensus and 10 healthy volunteers was analyzed in an Ultra-high Performance Liquid Chromatograph Coupled Mass Spectrometry (UPLCMS). Results: The results showed an increased concentration in SS of metabolites involved in oxidative stress such as lactate, alanine and malate, and amino acids involved in the growth and proliferation of T-cells, such as arginine, leucine valine and isoleucine. Conclusions: These results revealed that is possible to differentiate the metabolic profile of SS and healthy individuals using a small amount of saliva, which in its turn may reflect the cellular changes observed in the microenvironments of damaged salivary glands from these patients. Objective Sjögrens Sjögren s (SS exocrinopathy although erythematosus arthritis scleroderma approach Methods 1 AmericanEuropean American European Ultrahigh Ultra high UPLCMS. UPLCMS . (UPLCMS) Results lactate malate Tcells, Tcells T cells, cells T-cells arginine isoleucine Conclusions (UPLCMS

https://doi.org/10.1016/j.clinsp.2024.100459

Survival benefit of pediatric-based regimen for adults with acute lymphoblastic leukemia: A single-center retrospective cohort pediatricbased pediatric based leukemia singlecenter single center
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Queiroz Neto, Miguel Pedro de

; Costa, Larissa da

; Lisboa, Erica Sabrine Angelo

; Silva, Silvia Nathalia Bueno

; Azambuja, Ana Paula de

; Nunes, Elenaide Coutinho

; Bendlin, Rodrigo Miguel

Hematology, Transfusion and Cell Therapy

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jul 2023, Volume 45 Suppl. 2 Pages S18 - S24

Abstract: En | Text: En | PDF: En

ABSTRACT Introduction: Improving survival of Acute Lymphoblastic Leukemia (ALL) in adult patients has been a challenge. Despite intensive chemotherapy treatment, overall survival is poor. However, several studies demonstrate that young adult patients have better survival when treated with pediatric-based intensive regimens. Considering these results, We decided to treat newly diagnosed ALL patients according to age and risk factors. The goal of this study was to describe the results of this intensive chemotherapy treatment approach for ALL adult patients diagnosed at our institution. Methods: Fifty-eight ALL patients, diagnosed from 2004 to 2013, were included in the analysis. Patients were assigned to either the St. Jude Total Therapy XIIIB high-risk arm (St Jude) or the CALGB 8811 (CALGB). The Kaplan-Meier survival curve was used for the survival analyses and the Cox proportional hazard regression, for multivariable analysis. Results: The overall survival was 22.9% at 10 years. The St. Jude improved survival, compared to the CALGB (p = 0.007), with 32.6% vs. 7.4% survival rate at 10 years. However, no survival benefit was found for patients younger than 20 years old (p = 0.32). The multivariable analysis demonstrated that undetectable minimal residual disease (MRD) and hematopoietic stem cell transplantation (HSCT) had beneficial impact on survival (p = 0.0007 and p = 0.004, respectively). Conclusion: ALL is a disease of poor prognosis for adults. The joint effort to standardize treatment and seek solutions is the way to start improving this scenario. Introduction (ALL challenge However pediatricbased pediatric based regimens factors institution Methods Fiftyeight Fifty eight 200 2013 St highrisk high 881 CALGB. . (CALGB) KaplanMeier Kaplan Meier regression Results 229 22 9 22.9 1 0.007, 0007 0.007 , 0 007 0.007) 326 32 6 32.6 vs 74 7 4 7.4 2 0.32. 032 0.32 0.32) MRD (MRD HSCT (HSCT 00007 0.000 0004 004 0.004 respectively. respectively respectively) Conclusion adults scenario 201 88 (CALGB 22. 000 0.00 00 3 32. 7. 03 0.3 0000 8 0.0 0.

https://doi.org/10.1016/j.htct.2021.08.016

[SciELO Preprints] - EVALUATION OF THE SATISFACTION OF REMOTE TEACHING IN POSTGRADUATE COURSES IN HEALTH: SYSTEMATIC REVIEW
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Campos Filho, Amadeu Sa de Reis, Mateus Souza Farias, Bruna Loiola Coutinho de Lima, Igor Vinícius Anadias de Mello, Carolina Ribeiro Lins e Sarinho, Silvia Wanick

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Publication date: 2023-05-05

Abstract: En Es Pt

Objective: To analyze and identify in the scientific literature how remote teaching is being used and how it was evaluated in postgraduate health courses. Methods: Systematic review with a search in the Virtual Health Library (VHL), with the descriptors distance education, remote learning, residency, graduate studies and health in Portuguese and English, between 2017 and 2021, in Portuguese, English and Spanish. Results: From 750 initial results, 19 articles were included. The United States leads with the largest number of publications on the subject. The evaluation of students who studied through remote teaching is positive. Conclusion: Remote teaching was introduced very quickly for a large number of specialties in the world, with this, even showing positive aspects in this type of teaching, some negative points were evident and that future improvements must be made

Objetivo: Analizar e identificar en la literatura científica el uso de la enseñanza a distancia y su evaluación en los cursos de posgrado en salud. Métodos: Revisión sistemática en las bases de datos Medline, Lilacs, BDEnf, IBECS, BBO y BDENF con los descriptores educación a distancia, aprendizaje a distancia, residencia, estudios de posgrado y salud entre 2017 y 2021, en portugués, inglés y español. Resultados: La búsqueda inicial identificó 750 resultados. En la fase de análisis de títulos y resúmenes quedaron 66 estudios. Finalmente, se incluyeron 19 artículos. Estados Unidos lidera con el mayor número de publicaciones sobre el tema. La valoración de los alumnos que estudiaron a través de la docencia a distancia es positiva. Conclusión: La enseñanza a distancia se implementó muy rápidamente para una gran cantidad de especialidades en el mundo, con lo que, aun mostrando aspectos positivos en este tipo de enseñanza, se evidenciaron algunos puntos negativos y que se deben realizar mejoras futuras

Objetivo: Analisar e identificar na literatura científica a utilização do ensino remoto e sua avaliação em cursos de pós-graduação em saúde. Métodos: Revisão sistemática nas bases de dados Medline, Lilacs, BDEnf, IBECS, BBO e BDENF com os descritores educação a distância, ensino remoto, residência, pós-graduação e saúde entre 2017 a 2021, nos idiomas português, inglês e espanhol. Resultados: A busca inicial identificou 750 resultados. Na fase de análise dos títulos e resumos sobraram 66 estudos. Por fim foram incluídos 19 artigos. Os Estados Unidos lideram com o maior número de publicações acerca do tema. A avaliação dos discentes que estudaram através do ensino remoto é positiva. Conclusão: O ensino remoto foi colocado de forma muito rápida para uma grande quantidade de especialidades no mundo, com isso, mesmo evidenciando-se aspectos positivos nesse tipo de ensino, ficou evidente alguns pontos negativos e que se deve fazer melhorias futuras.

https://doi.org/10.1590/SciELOPreprints.6014

Posicionamento sobre Doença Isquêmica do Coração – A Mulher no Centro do Cuidado – 2023 202 20 2
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Oliveira, Gláucia Maria Moraes de

; Almeida, Maria Cristina Costa de

; Rassi, Daniela do Carmo

; Bragança, Érika Olivier Vilela

; Moura, Lidia Zytynski

; Arrais, Magaly

; Campos, Milena dos Santos Barros

; Lemke, Viviana Guzzo

; Avila, Walkiria Samuel

; Lucena, Alexandre Jorge Gomes de

; Almeida, André Luiz Cerqueira de

; Brandão, Andréa Araujo

; Ferreira, Andrea Dumsch de Aragon

; Biolo, Andreia

; Macedo, Ariane Vieira Scarlatelli

; Falcão, Breno de Alencar Araripe

; Polanczyk, Carisi Anne

; Lantieri, Carla Janice Baister

; Marques-Santos, Celi

; Freire, Claudia Maria Vilas

; Pellegrini, Denise

; Alexandre, Elizabeth Regina Giunco

; Braga, Fabiana Goulart Marcondes

; Oliveira, Fabiana Michelle Feitosa de

; Cintra, Fatima Dumas

; Costa, Isabela Bispo Santos da Silva

; Silva, José Sérgio Nascimento

; Carreira, Lara Terra F.

; Magalhães, Lucelia Batista Neves Cunha

; Matos, Luciana Diniz Nagem Janot de

; Assad, Marcelo Heitor Vieira

; Barbosa, Marcia M.

; Silva, Marconi Gomes da

; Rivera, Maria Alayde Mendonça

; Izar, Maria Cristina de Oliveira

; Costa, Maria Elizabeth Navegantes Caetano

; Paiva, Maria Sanali Moura de Oliveira

; Castro, Marildes Luiza de

; Uellendahl, Marly

; Oliveira Junior, Mucio Tavares de

; Souza, Olga Ferreira de

; Costa, Ricardo Alves da

; Coutinho, Ricardo Quental

; Silva, Sheyla Cristina Tonheiro Ferro da

; Martins, Sílvia Marinho

; Brandão, Simone Cristina Soares

; Buglia, Susimeire

; Barbosa, Tatiana Maia Jorge de Ulhôa

; Nascimento, Thais Aguiar do

; Vieira, Thais

; Campagnucci, Valquíria Pelisser

; Chagas, Antonio Carlos Palandri

Arquivos Brasileiros de Cardiologia

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2023, Volume 120 N. 7 elocation e20230303

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.36660/abc.20230303

WEIGHT REGAIN AND THE METABOLIC PROFILE OF WOMEN IN THE POSTOPERATIVE PERIOD OF BARIATRIC SURGERY: A MULTIVARIATE ANALYSIS SURGERY
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Santos, Andréia Lira

; Silva, Silvia Alves da

; Cavalcante-E-Silva, Larissa Maria

; Leão, Luís Henrique de Albuquerque

; Coutinho, Lucas Ribeiro

; Oliveira, Fernando de Santa Cruz

; Ferraz, Álvaro Antonio Bandeira

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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2023, Volume 36 elocation e1755

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO RACIONAL: Reganho de peso no pós-operatório de cirurgia bariátrica está diretamente relacionado à recidiva das comorbidades pré-operatórias e a um impacto negativo no perfil bioquímico desses pacientes. OBJETIVOS: avaliar o impacto metabólico do reganho de peso nas comorbidades pré-operatórias e no perfil bioquímico desses pacientes, a fim de mostrar o impacto das complicações nos desfechos metabólicos finais da cirurgia bariátrica. MÉTODOS: Estudo retrospectivo que analisou 75 mulheres no pós-operatório tardio de cirurgia bariátrica que apresentaram reganho patológico de peso (=20% do máximo de peso perdido). Foram coletados dados referentes às medidas dos perfis glicêmico, lipídico e inflamatório em três momentos distintos de avaliação: no pré-operatório, no nadir de peso (menor peso) e após o reganho ponderal. Foi realizada uma análise multivariada. RESULTADOS: A idade média foi 46.39±12.09 anos. IMC médio pré-operatório foi 40.10±4.11 kg/m2. Houve um aumento de 3,36 pontos no IMC médio entre o nadir e após reganho: de 26.30±3.9 Kg/m2 para 29.66±4.66 Kg/m2. O tempo médio para atingir o nadir foi de 18±7.6 meses, com uma %PEP de 91.08±11.8%. O tempo médio para o reganho patológico foi de 48 meses, e a média de reganho foi 8.85±5.65 kg. Houve correlação significativa entre o reganho patológico e os níveis de insulina (r=0.351; p<0.011), peptídeo C (r=0.303; p<0.011), proteína C reativa (r=0.402; p<0.001) e vitamina D (r=-0.435; p<0.001), sendo os dois últimos os mais influenciados pela porcentagem de reganho de peso. CONCLUSÕES: O reganho de peso patológico no pós-operatório de cirurgia bariátrica resulta em prejuízos ao perfil metabólico e inflamatório dos pacientes. No entanto, os benefícios bioquímicos perduram em relação aos níveis pré-operatórios dos parâmetros analisados RACIONAL pósoperatório pós operatório préoperatórias pré operatórias pacientes OBJETIVOS MÉTODOS 7 =20% 20 (=20 perdido. perdido . perdido) glicêmico avaliação préoperatório, préoperatório operatório, menor ponderal multivariada RESULTADOS 46391209 46 39 12 09 46.39±12.0 anos 4010411 40 10 4 11 40.10±4.1 kgm2 kgm kg m2 m kg/m2 336 3 36 3,3 263039 26 30 9 26.30±3. Kgm2 Kgm Kg Kg/m 2966466 29 66 29.66±4.6 1876 18 6 18±7. meses PEP 9108118 91 08 8 91.08±11.8% 885565 85 5 65 8.85±5.6 r=0.351 r0351 r 0 351 (r=0.351 p<0.011, p0011 p p<0.011 , 011 p<0.011) r=0.303 r0303 303 (r=0.303 r=0.402 r0402 402 (r=0.402 p<0.001 p0001 001 r=0.435 r0435 r= 0.435 435 (r=-0.435 p<0.001, CONCLUSÕES entanto préoperatórios operatórios =20 2 (=2 4639120 1 46.39±12. 401041 40.10±4. kg/m 33 3, 26303 26.30±3 296646 29.66±4. 187 18±7 910811 91.08±11.8 88556 8.85±5. r=0.35 r035 35 (r=0.35 p001 p<0.01 01 r=0.30 r030 (r=0.30 r=0.40 r040 (r=0.40 p<0.00 p000 00 r=0.43 r043 0435 0.43 43 (r=-0.43 =2 (= 463912 46.39±12 40104 40.10±4 2630 26.30± 29664 29.66±4 18± 91081 91.08±11. 8855 8.85±5 r=0.3 r03 (r=0.3 p00 p<0.0 r=0.4 r04 (r=0.4 043 0.4 (r=-0.4 = ( 46391 46.39±1 4010 40.10± 263 26.30 2966 29.66± 9108 91.08±11 885 8.85± r=0. r0 (r=0. p0 p<0. 04 0. (r=-0. 4639 46.39± 401 40.10 26.3 296 29.66 910 91.08±1 88 8.85 r=0 (r=0 p<0 (r=-0 463 46.39 40.1 26. 29.6 91.08± 8.8 (r= p< (r=- 46.3 40. 29. 91.08 8. (r 46. 91.0 91.

ABSTRACT BACKGROUND: Weight regain in the postoperative period after bariatric surgery is directly related to the relapse of preoperative comorbidities and a negative impact on the patients’ biochemical profile. AIMS: To assess the metabolic impact of weight regain on preoperative comorbidities and on patients’ biochemical profiles, in order to show the impact of the complications on the metabolic outcomes of bariatric surgery. METHODS: A retrospective study was carried out with 75 women in the late postoperative period of bariatric surgery who presented pathological weight regain (≥20% of the maximum weight loss). Data of interest consisted of glycemic, lipid, and inflammatory profile measurements at three different moments of evaluation: preoperative period, at the weight nadir (minimum weight), and after weight regain. A multivariate analysis was performed. RESULTS: The mean age was 46.39±12.09 years. Preoperative body mass index was 40.10±4.11 kg/m2. There was an overall increase of 3.36 points in the mean body mass index between the nadir and after regain: from 26.30±3.9 kg/m2 to 29.66±4.66 kg/m2. The mean time to reach the nadir was 18±7.6 months, with an average percentage of excess weight loss of 91.08±11.8%. The median time for pathological weight regain was 48 months, and the mean regain amongst the sample was 8.85±5.65 kg. There was a significant correlation between pathological weight regain and levels of insulin (r=0.351; p<0.011), C-peptide (r=0.303; p<0.011), C-reactive protein (r=0.402; p<0.001), and vitamin D (r=-0.435; p<0.001), the last two being the most influenced by the percentage of weight regained. CONCLUSIONS: The pathological weight regain in the postoperative period of bariatric surgery results in losses in the patients’ metabolic and inflammatory profiles. However, the biochemical benefits are sustained up to the preoperative levels of the parameters analyzed. BACKGROUND patients AIMS profiles METHODS 7 ≥20% 20 (≥20 loss. . loss) glycemic lipid evaluation minimum weight, , weight) performed RESULTS 46391209 46 39 12 09 46.39±12.0 years 4010411 40 10 4 11 40.10±4.1 kgm2 kgm kg m2 m 336 3 36 3.3 263039 26 30 9 26.30±3. kg/m 2966466 29 66 29.66±4.6 1876 18 6 18±7. months 9108118 91 08 8 91.08±11.8% 885565 85 5 65 8.85±5.6 r=0.351 r0351 r 0 351 (r=0.351 p<0.011, p0011 p p<0.011 011 p<0.011) Cpeptide C peptide r=0.303 r0303 303 (r=0.303 Creactive reactive r=0.402 r0402 402 (r=0.402 p<0.001, p0001 p<0.001 001 p<0.001) r=0.435 r0435 r= 0.435 435 (r=-0.435 regained CONCLUSIONS However analyzed ≥20 2 (≥2 4639120 1 46.39±12. 401041 40.10±4. 33 3. 26303 26.30±3 296646 29.66±4. 187 18±7 910811 91.08±11.8 88556 8.85±5. r=0.35 r035 35 (r=0.35 p001 p<0.01 01 r=0.30 r030 (r=0.30 r=0.40 r040 (r=0.40 p000 p<0.00 00 r=0.43 r043 0435 0.43 43 (r=-0.43 ≥2 (≥ 463912 46.39±12 40104 40.10±4 2630 26.30± 29664 29.66±4 18± 91081 91.08±11. 8855 8.85±5 r=0.3 r03 (r=0.3 p00 p<0.0 r=0.4 r04 (r=0.4 043 0.4 (r=-0.4 ≥ ( 46391 46.39±1 4010 40.10± 263 26.30 2966 29.66± 9108 91.08±11 885 8.85± r=0. r0 (r=0. p0 p<0. 04 0. (r=-0. 4639 46.39± 401 40.10 26.3 296 29.66 910 91.08±1 88 8.85 r=0 (r=0 p<0 (r=-0 463 46.39 40.1 26. 29.6 91.08± 8.8 (r= p< (r=- 46.3 40. 29. 91.08 8. (r 46. 91.0 91.

https://doi.org/10.1590/0102-672020230037e1755

RELATIONSHIP BETWEEN TBS SCORE, BONE DENSITY AND FRACTURES IN OLDER MEN: INTEGRATIVE REVIEW
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BORBA, ALEXANDRE COUTINHO

; TERRA, NEWTON LUIZ

; AREOSA, SILVIA VIRGINIA COUTINHO

Acta Ortopédica Brasileira

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2022, Volume 30 N. 4 elocation e253507

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O envelhecimento populacional é uma realidade inexorável. Portanto o número de estudos relacionados às patologias comuns em idosos, como a osteoporose, tende a crescer. A osteoporose é uma doença caracterizada pelo aumento da fragilidade óssea, elevando o risco de fratura. Embora seja uma patologia predominante em mulheres, os estudos analisando a população masculina tem despertado interesse na comunidade científica. Entretanto, ainda não há consenso sobre a melhor forma estimar o risco de fratura. A densitometria óssea e a avalição do trabecular bone score (TBS) são alternativas disponíveis para o diagnóstico. Avaliar a relação entre a densidade mineral óssea, a alteração do TBS e a presença de fratura em idosos masculinos. Realizou-se uma revisão integrativa da literatura nas bases de dados LILACS, Scopus e PubMed, procurando estudos realizados nos últimos cinco anos. Foram encontrados 97 estudos, sendo que cinco se adequavam aos nossos critérios de seleção. Todos os estudos mostraram a importância do uso do TBS para uma melhor acurácia no intuito de aprimorar a estimativa do risco de fratura em homens idosos. A associação do TBS com a densidade óssea é útil para estimar de forma mais adequada o risco de fratura. Nível de Evidência II, Estudos Diagnósticos.

ABSTRACT Population ageing is an inexorable truth. This is the reason for an increase in the number of studies analyzing common pathologies, such as osteoporosis, in older people. Osteoporosis is a disease resulting from bone fragility, thus increasing the risk of fracture. Although the occurrence is predominant in women, studies analyzing the male population have raised interest among the scientific community. Nevertheless, there is no consensus regarding the best way to estimate the risk of fracture. Bone density testing and TBS (trabecular bone score) assessments are alternatives available for diagnosing. To assess the relationship between bone mineral density, the changes in TBS and fractures in older men. We conducted an integrative review of the literature in the LILACS, Scopus and PubMed databases, searching for studies in the last five years. We found 97 studies, and five of these matched our guiding question. We found five articles that matched our selecting criteria. All five presented the importance of using TBS for a better accuracy in improving the estimate of risk of fracture in older men. The association of TBS with bone density is important to best estimate the risk of fracture in elder men. Level of Evidence II, Diagnostic Studies.

https://doi.org/10.1590/1413-785220223004e253507

Relevant proteins for the monitoring of engraftment phases after allogeneic hematopoietic stem cell transplantation
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Souza, Milena Monteiro

; Coutinho-Camillo, Cláudia Malheiros

; de Paula, Fabiana Martins

; de Paula, Fernanda

; Bologna, Sheyla Batista

; Lourenço, Silvia Vanessa

Clinics

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2022, Volume 77 elocation 100134

Abstract: En | Text: En | PDF: En

Abstract Introduction Hematopoietic Stem Cell Transplant (HSCT) has been successfully used as standard therapy for hematological disorders. After conditioning therapy, patients undergoing allogeneic HSCT, present three different phases of engraftment: early pre-engraftment, early post-engraftment, and late engraftment. Severe complications are associated with morbidity, mortality, and malignancies in these phases, which include effects on the oral cavity. Objectives The changes in the salivary composition after HSCT may contribute to identifying relevant proteins that could map differences among the phases of diseases, driven for personalized diagnostics and therapy. Methods Unstimulated whole saliva was collected from patients submitted to HSCT. The samples were submitted to trypsin digestion for a Mass spectrometry analysis. MaxQuant processed the Data analysis, and the relevant expressed proteins were subjected to pathway and network analyses. Results Differences were observed in the most identified proteins, specifically in proteins involved with the regulation of body fluid levels and the mucosal immune response. The heatmap showed a list of proteins exclusively expressed during the different phases of HSCT: HBB, KNG1, HSPA, FGB, APOA1, PFN1, PRTN3, TMSB4X, YWHAZ, CAP1, ACTN1, CLU and ALDOA. Bioinformatics analysis implicated pathways involved in protein processing in the endoplasmic reticulum, complement and coagulation cascades, apoptosis signaling, and cholesterol metabolism. Conclusion The compositional changes in saliva reflected the three phases of HSCT and demonstrated the usefulness of proteomics and computational approaches as a revolutionary field in diagnostic methods. (HSCT disorders engraftment preengraftment, preengraftment pre engraftment, pre-engraftment postengraftment, postengraftment post post-engraftment morbidity mortality cavity diseases analyses response HBB KNG1 KNG HSPA FGB APOA1 APOA PFN1 PFN PRTN3 PRTN TMSB4X TMSBX TMSB X YWHAZ CAP1 CAP ACTN1 ACTN ALDOA reticulum cascades signaling metabolism methods

https://doi.org/10.1016/j.clinsp.2022.100134

Atualização da Diretriz Brasileira de Hipercolesterolemia Familiar – 2021
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Izar, Maria Cristina de Oliveira

; Giraldez, Viviane Zorzanelli Rocha

; Bertolami, Adriana

; Santos Filho, Raul Dias dos

; Lottenberg, Ana Maria

; Assad, Marcelo Heitor Vieira

; Saraiva, José Francisco Kerr

; Chacra, Ana Paula M.

; Martinez, Tania L. R.

; Bahia, Luciana Ribeiro

; Fonseca, Francisco Antonio Helfenstein

; Faludi, Andre Arpad

; Sposito, Andrei C.

; Chagas, Antônio Carlos Palandri

; Jannes, Cinthia Elim

; Amaral, Cristiane Kovacs

; Araújo, Daniel Branco de

; Cintra, Dennys Esper

; Coutinho, Elaine dos Reis

; Cesena, Fernando

; Xavier, Hermes Toros

; Mota, Isabela Cardoso Pimentel

; Giuliano, Isabela de Carlos Back

; Faria Neto, José Rocha

; Kato, Juliana Tieko

; Bertolami, Marcelo Chiara

; Miname, Marcio Hiroshi

; Castelo, Maria Helane Costa Gurgel

; Lavrador, Maria Sílvia Ferrari

; Machado, Roberta Marcondes

; Souza, Patrícia Guedes de

; Alves, Renato Jorge

; Machado, Valeria Arruda

; Salgado Filho, Wilson

Arquivos Brasileiros de Cardiologia

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oct 2021, Volume 117 N. 4 Pages 782 - 844

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210788 231 downloads

Implementação da política de acessibilidade comunicativa: o segmento televisivo em canais abertos de veiculação estadual
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Goerck, Cleonice Sabine

; Areosa, Silvia Virginia Coutinho

Intercom: Revista Brasileira de Ciências da Comunicação

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aug 2021, Volume 44 N. 2 Pages 215 - 232

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Atualmente, há no Brasil mais de 12,5 milhões de pessoas que possuem algum tipo de deficiência – visual, auditiva, motora, mental ou intelectual. Este número, apresentado pelo IBGE em 2018, indica que, pelo menos, cerca de 3,4% dos brasileiros não têm acesso pleno à programação da televisão aberta. Ter acesso a todo tipo de comunicação faz com que todas as pessoas com deficiência possam não apenas estar incluídas na sociedade, mas também garante um dos direitos previstos na Constituição Federal, que é o direito à informação. Sendo assim, as emissoras de TV deveriam estar preparadas para atender a esta fatia da audiência. Diante desta realidade, o objetivo dessa pesquisa foi o de conhecer a atual situação no que diz respeito a implementação da política pública de acessibilidade nas emissoras privadas de sinal aberto do estado do Rio Grande do Sul.

Abstract There are currently more than 12.5 million people in Brazil who have some type of disability – visual, hearing, motor, mental or intellectual. This figure, presented by the IBGE in 2018, indicates that at least about 3.4% of Brazilians do not have full access to broadcast television programming. Having access to all kinds of communication means that all persons with disabilities can not only be included in society, but also guarantee one of the rights provided for in the Federal Constitution, which is the right to information. As such, TV stations should be prepared to cater for this slice of the audience. Given this reality, the objective of this research was to know the current situation regarding the implementation of public accessibility policy in the private broadcasters of the state of Rio Grande do Sul.

Resumen Actualmente hay más de 12,5 millones de personas en Brasil que tienen algún tipo de discapacidad: visual, auditiva, motora, mental o intelectual. Esta cifra, presentada por el IBGE en 2018, indica que al menos alrededor del 3,4% de los brasileños no tiene pleno acceso a la programación televisiva. Tener acceso a todo tipo de comunicación significa que todas las personas con discapacidad no solo pueden ser incluidas en la sociedad, sino que también garantizan uno de los derechos previstos en la Constitución Federal, que es el derecho a la información. Como tal, las estaciones de televisión deben estar preparadas para atender a este segmento de la audiencia. Dada esta realidad, el objetivo de esta investigación fue conocer la situación actual con respecto a la implementación de la política de accesibilidad pública en las emisoras privadas del estado de Rio Grande do Sul.

https://doi.org/10.1590/1809-58442021212 110 downloads

10.

Avaliação do tempo de reação em crianças com anemia falciforme
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Marinello, Kellen Carvalho Vicentina

; Pereira, Maria Claudia

; Rocha Junior, Valdinar de Araújo

; Medeiros, Flavia Vanessa de Araujo

; Teles, Fernanda Sampaio

; Coutinho, Sílvia Maria Gonçalves

; Carmo, Jake Carvalho do

Motricidade

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mar 2021, Volume 17 N. 1 Pages 7 - 14

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A anemia falciforme é uma doença crônica capaz de afetar gravemente a habilidade de processar rapidamente uma informação. O objetivo deste estudo foi avaliar o tempo de reação em crianças portadoras de anemia falciforme, usando testes de tempo de reação simples e tempo de reação de escolha . Foi realizado um estudo transversal no Hospital da Criança de Brasília, com pacientes do ambulatório de hematologia. O grupo experimental foi composto por 24 crianças falcêmicas e o grupo controle por 22 crianças não afetadas pela enemia falciforme. O tempo de reação simples e o tempo de reação de escolha foram avaliados por meio de equipamentos desenvolvidos para esse fim. Os resultados mostraram déficit significativo no tempo de reação de escolha das crianças com anemia falciforme (p= 0.000161). No tempo de reação simples o grupo experimental apresentou menor atenção, cometendo uma maior proporção de erros por omissão, quando comparado ao grupo experimental (p= 0.00678). O menor índice de acerto nos testes de tempo de reação simpoles e tempo de reação de escolha em crianças com anemia falciforme pode estar relacionada à alta prevalência de infarto cerebral silencioso nessa população. Outro fato que pode ser associado ao aumento do tempo de reação nas crianças portadoras de anemia falciforme é a falta de vivência e oportunidades de atividades motoras ao longo da infância em razão da patologia.

ABSTRACT Sickle cell anemia is a chronic disease that can severely affect the ability to process information quickly. The aim of this study was to evaluate the reaction time in children with sickle cell anemia using simple reaction time and choice reaction time tests. A cross-sectional study was performed at the Children's Hospital of Brasília, with patients from the hematology outpatient clinic. The experimental group was composed of 24 sickle cell children and the control group by 22 children not affected by sickle cell anemia. The simple reaction time and choice reaction time were evaluated using equipment developed for this purpose. The results showed a significant deficit in the choice reaction time of children with sickle cell anemia (p= 0.000161). In simple reaction time, the experimental group showed less attention, committing a higher proportion of errors by omission when compared to control group (p= 0.00678). The lower rate of success in simple reaction time and choice reaction time tests in children with sickle cell anemia may be related to the high incidence of silent cerebral infarction in this population. Another fact that may be associated with high reaction time in patients with sickle cell anemia is the lack of experience and opportunities for motor activities throughout childhood due to the pathology.

https://doi.org/10.6063/motricidade.18935 579 downloads

11.

Suckling by Schistosoma mansoni-infected mothers restored IgG2a and TGF-β production, but not IL-6 and delayed-type hypersensitivity in IL-12/IL-23-deficient mice
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Silva, Fabiana Leticia da

; Silva, Maria da Conceição

; Holanda, Gabriela Calixto Ribeiro de

; Coutinho, Eridan de Medeiros

; Montenegro, Silvia Maria Lucena

; Morais, Clarice Neuenschwander Lins de

; Souza, Valdênia Maria Oliveira de

Revista da Sociedade Brasileira de Medicina Tropical

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2021, Volume 54 elocation e0744-2020

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION Suckling by schistosomotic mice improves anti-ovalbumin (OA) antibody production, while delayed-type hypersensitivity (DTH) remains unaffected. This property of milk from schistosomotic mice was investigated in IL-12/IL-23-deficient mice (IL-12p40KO). METHODS We compared anti-OA DTH, IgG2a and cytokines in wild-type and IL-12p40KO mice suckled by infected (SIM) or non-infected (CONTROL) mothers. RESULTS SIM mice showed similar intensity and eosinophils in the DTH, which was abolished in IL-12p40KO and IL-12p40KO-SIM mice. In IL-12p40KO-SIM, IgG2a and TGF-β levels were higher, but IL-6 levels were lower. CONCLUSIONS Milk from schistosomotic mothers may evoke IgG2a without eliciting DTH in IL-12/IL-23 deficiencies, by changing TGF-β/IL-6 levels.

https://doi.org/10.1590/0037-8682-0744-2020 220 downloads

12.

Diretriz Brasileira de Cardio-oncologia – 2020
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Hajjar, Ludhmila Abrahão

; Costa, Isabela Bispo Santos da Silva da

; Lopes, Marcelo Antônio Cartaxo Queiroga

; Hoff, Paulo Marcelo Gehm

; Diz, Maria Del Pilar Estevez

; Fonseca, Silvia Moulin Ribeiro

; Bittar, Cristina Salvadori

; Rehder, Marília Harumi Higuchi dos Santos

; Rizk, Stephanie Itala

; Almeida, Dirceu Rodrigues

; Fernandes, Gustavo dos Santos

; Beck-da-Silva, Luís

; Campos, Carlos Augusto Homem de Magalhães

; Montera, Marcelo Westerlund

; Alves, Sílvia Marinho Martins

; Fukushima, Júlia Tizue

; Santos, Maria Verônica Câmara dos

; Negrão, Carlos Eduardo

; Silva, Thiago Liguori Feliciano da

; Ferreira, Silvia Moreira Ayub

; Malachias, Marcus Vinicius Bolivar

; Moreira, Maria da Consolação Vieira

; Valente Neto, Manuel Maria Ramos

; Fonseca, Veronica Cristina Quiroga

; Soeiro, Maria Carolina Feres de Almeida

; Alves, Juliana Barbosa Sobral

; Silva, Carolina Maria Pinto Domingues Carvalho

; Sbano, João

; Pavanello, Ricardo

; Pinto, Ibraim Masciarelli F.

; Simão, Antônio Felipe

; Dracoulakis, Marianna Deway Andrade

; Hoff, Ana Oliveira

; Assunção, Bruna Morhy Borges Leal

; Novis, Yana

; Testa, Laura

; Alencar Filho, Aristóteles Comte de

; Cruz, Cecília Beatriz Bittencourt Viana

; Pereira, Juliana

; Garcia, Diego Ribeiro

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

; Macedo, Ariane Vieira Scarlatelli

; Marcatti, Patricia Tavares Felipe

; Mathias Junior, Wilson

; Wiermann, Evanius Garcia

; Val, Renata do

; Freitas, Helano

; Coutinho, Anelisa

; Mathias, Clarissa Maria de Cerqueira

; Vieira, Fernando Meton de Alencar Camara

; Sasse, André Deeke

; Rocha, Vanderson

; Ramires, José Antônio Franchini

; Kalil Filho, Roberto

Arquivos Brasileiros de Cardiologia

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nov 2020, Volume 115 N. 5 Pages 1006 - 1043

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201006 4180 downloads

13.

Evolution of myelodisplasic syndrome with ring sideroblasts (MDS-RS) to systemic mastocytosis and aleukemic mast cell leukemia
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Costa, Larissa da

; Azambuja, Ana Paula de

; Ângelo Lisboa, Erica Sabrine

; Bueno, Silvia Natalia

; Coutinho, Elenaide Nunes

; Spinelli, Bruno Francisco Buzinetti

; Medeiros, Larissa Alessandra

; Funke, Vaneuza de Araujo Moreira

; Malvezzi, Mariester

Hematology, Transfusion and Cell Therapy

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oct 2020, Volume 42 N. 4 Pages 387 - 389

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.htct.2019.08.003 157 downloads

14.

Invasión ósea del carcinoma de células escamosas de la cavidad oral, análisis clínico - patológico de 62 casos
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Vaz Vanini, Jaqueline

; Hoyos Cadavid, Ana Maria

; Malheiros Coutinho-Camillo, Cláudia

; de Matos, Leandro Luongo

; Cernea, Claudio R

; Lourenço, Silvia Vanessa

Revista Estomatológica Herediana

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apr 2020, Volume 30 N. 2 Pages 78 - 85

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

SUMMARY Introduction: Prognosis for patients with squamous cell carcinoma (SCC) in oral cavity with bone invasion presence is concerning. Bone invasion patterns can be used to indicate aggressiveness and can be correlated with tumor clinical behavior. Objective: To evaluate bone invasion histopathological patterns in patients with oral cavity SCC and correlate them with the survival rate. Materials and methods: 62 patients with presence of SCC in the oral cavity as well as bone invasion were recruited for this study. Epidemiological and histopathological characteristics were tabulated and analyzed. Fischer’s Square and Exact Tests were used to verify any statistical associations between the data. Results: More men were affected, especially in the fifth decade of life, and a strong association with smoking and chronic alcoholism was observed. Deaths were reported in 58% of patients, over a period of 5 years. The most prevalent histological pattern was the infiltrative, associated with lower survival rates. Conclusion: An analysis of the histopathological patterns of oral cavity SCC can be used as a prognostic factor thereby assisting with the decision of which oncological treatment approach to use.

RESUMEN Introducción: El pronóstico de pacientes con carcinoma de células escamosas (CEC) de la cavidad oral con presencia de invasión ósea continua sombrío. El patrón de invasión ósea puede ser usado como indicador de agresividad y correlacionado con el comportamiento clínico del tumor. Objetivo: Evaluar los patrones histopatológicos de invasión ósea en pacientes con CEC de la cavidad oral y correlacionarlos con la tasa de sobrevida. Materiales y métodos: La muestra fue constituida por 62 pacientes con presencia de CEC en la cavidad oral e invasión ósea. Las características epidemiológicas e histopatológicas fueron tabuladas y analizadas. Los Test Chi- cuadrado y exacto de Fischer fueron empleados para verificar las asociaciones estadísticas entre los datos. Resultados: Fueron afectados más hombres en la quinta década de vida y observada una fuerte asociación con tabaquismo y etilismo crónico. Fueron relatadas muertes en 58% de los pacientes, en un periodo de 5 años. El patrón histológico más prevalente fue el infiltrativo, asociado a menores tasas de sobrevida. Conclusión: El análisis del patrón histopatológico de los CEC de la cavidad oral, puede ser usado como factor pronóstico auxiliando en la decisión del abordaje del tratamiento oncológico.

https://doi.org/10.20453/reh.v30i2.3759

15.

Resistance jump training may reverse the weakened biomechanical behavior of tendons of diabetic Wistar rats
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Silva, Raissa Thais Belarmino

; Castro, Patrícia Verçoza de

; Coutinho, Marcos Paulo Galdino

; Brito, Ana Camila Nobre de Lacerda

; Bezerra, Márcio Almeida

; Moraes, Silvia Regina Arruda de

Fisioterapia e Pesquisa

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dec 2017, Volume 24 N. 4 Pages 399 - 405

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Antecedentes: o treinamento de resistência é amplamente aplicado no protocolo físico não diabético mostrando eficiência na melhoria do tecido do tendão. Para abordar esta lacuna, avaliamos os efeitos do treinamento de resistência no ambiente aquático, nas propriedades biomecânicas do tendão calcâneo de ratos Wistar diabéticos. Métodos: 59 ratos Wistar machos foram avaliados por 60 dias, os quais foram divididos aleatoriamente nos seguintes grupos: Grupo de Controle Sedentário (GCS, n=15), Grupo Diabético Sedentário (GDS, n=15), Grupo de Controle Treinado (GCT, n=14) e Grupo Diabético Treinado (GDT, n=15). Após a randomização, os animais do GDS e do CDT foram induzidos a diabetes mellitus por injeção intraperitoneal de Streptozotocin (60mg/kg). Os animais dos grupos treinados realizaram exercícios de resistência que consistiam em saltar em um ambiente aquático. Após nove semanas, os tendões calcaneares foram coletados e tracionados em uma máquina convencional de teste mecânico. Resultados: A análise dos parâmetros biomecânicos mostrou valores mais baixos em módulo elástico (p=0,000), tensão máxima de força (p=0,000) e energia/área (p=0,008) em GDT em comparação com GDS, além de um aumento na área transversal (p=0,002). Não houve diferença para a variável de deformação específica. Conclusão: o protocolo de treinamento usado restaurou alguns parâmetros biomecânicos do tendão calcâneo em ratos induzidos a diabetes, resultando, assim, na melhoria da eficiência mecânica.

ABSTRACT Background: resistance training is widely applied in non-diabetic physical protocol showing effectiveness in improving the tendon tissue. To address this gap, we assessed the effects of resistance training on aquatic environment, on the biomechanical properties of the calcaneal tendon of diabetic Wistar rats. Methods: 59 male Wistar rats were evaluated for 60 days, they were randomly divided into the following groups: Sedentary Control Group (SCG, n=15), Sedentary Diabetic Group (SDG, n=15), Trained Control Group (TCG, n=14) and Trained Diabetic Group (TDG, n=15). After randomization the animals from the SDG and the TDG were induced to Diabetes Mellitus by intraperitoneal injection of Streptozotocin (60 mg/kg). The animals on the trained groups performed resistance exercise that consisted of jumping in an aquatic environment. After nine weeks the calcaneal tendons were collected and tractioned on a conventional mechanical testing machine. Results: the analysis of biomechanical parameters showed lower values in elastic modulus (p=0.000), maximum strength tension (p=0.000) and energy/area (p=0.008) in TDG compared to SDG in addition to an increase on the cross-sectional area (p=0.002). There was no difference for the specific deformation variable. Conclusion: the training protocol used restored some biomechanical parameters of the calcaneal tendon in rats induced to diabetes, thus, resulting in an improvement of its mechanical efficiency.

RESUMEN Antecedentes: el entrenamiento de resistencia se aplica ampliamente en el protocolo físico no diabético mostrándose la efectividad en la mejora del tejido del tendón. Para abordar esta brecha, evaluamos los efectos del entrenamiento de resistencia en el ambiente acuático, en las propiedades biomecánicas del tendón calcáneo de las ratas Wistar diabéticas. Métodos: se evaluaron 59 ratas Wistar machos durante 60 días, éstes se dividieron aleatoriamente en los siguientes grupos: Grupo de Control Sedentario (GCS, n=15), Grupo Diabético Sedentario (GDS, n=15), Grupo de Control Entrenado (GCE, n=14) y Grupo Diabético Entrenado (GDE, n=15). Después de la aleatorización, los animales del GDS y del GDE se indujeron a diabetes mellitus por inyección intraperitoneal de Streptozotocin (60mg/kg). Los animales de los grupos entrenados realizaron ejercicios de resistencia que consistían en saltar en un ambiente acuático. Después de nueve semanas, se recogieron y traccionaron los tendones calcaneales en una máquina convencional de prueba mecánica. Resultados: El análisis de los parámetros biomecánicos mostró valores más bajos en módulo elástico (p=0.000), tensión de fuerza máxima (p=0.000) y energía/área (p = 0.008) en GDE en comparación con GDS, además de un aumento en la área transversal (p=0.002). No hubo diferencia para la variable de deformación específica. Conclusión: el protocolo de entrenamiento utilizado restauró algunos parámetros biomecánicos del tendón calcáneo en ratas inducidas a la diabetes, lo que resultó en una mejora de su eficiencia mecánica.

https://doi.org/10.1590/1809-2950/17198024042017 1819 downloads

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