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Abstract Objective: Sjögren’s Syndrome (SS) is a chronic inflammatory autoimmune exocrinopathy, and although, the role of metabolism in the autoimmune responses has been discussed in diseases such as lupus erythematosus, rheumatoid arthritis, psoriasis and scleroderma. There is a lack of information regarding the metabolic implications of SS. Considering that the disease affects primarily salivary glands; the aim of this study is to evaluate the metabolic changes in the salivary glands’ microenvironment using a targeted metabolomics approach. Methods: The saliva from 10 patients diagnosed with SS by the American-European consensus and 10 healthy volunteers was analyzed in an Ultra-high Performance Liquid Chromatograph Coupled Mass Spectrometry (UPLCMS). Results: The results showed an increased concentration in SS of metabolites involved in oxidative stress such as lactate, alanine and malate, and amino acids involved in the growth and proliferation of T-cells, such as arginine, leucine valine and isoleucine. Conclusions: These results revealed that is possible to differentiate the metabolic profile of SS and healthy individuals using a small amount of saliva, which in its turn may reflect the cellular changes observed in the microenvironments of damaged salivary glands from these patients. Objective Sjögrens Sjögren s (SS exocrinopathy although erythematosus arthritis scleroderma approach Methods 1 AmericanEuropean American European Ultrahigh Ultra high UPLCMS. UPLCMS . (UPLCMS) Results lactate malate Tcells, Tcells T cells, cells T-cells arginine isoleucine Conclusions (UPLCMS

https://doi.org/10.1016/j.clinsp.2024.100459

Usefulness of prolactin levels in predicting the etiology of hyperprolactinemia in a cohort of 770 patients 77 7
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Vilar, Lucio

; Vilar, Clarice Freitas

; Lyra, Ruy

; Albuquerque, Luciano

; Garrido, Ana Carolina Thé

; Gadelha, Patrícia Sampaio

; Diniz, Erik Trovão

; Almeida, Marcos

; Cordeiro, Lucia Helena

; Carvalho, Erico Higino de

; Melo, Ana Teresa Bezerra de

; Medeiros, Karoline Matias

; Ferreira, Gabriel Rodrigues de Assis

; Mororó Neto, José Coelho

; Ximenes, Daniela Zago

; Madruga, Camila Ribeiro Coutinho

; Nunes, Rosália de Oliveira

; Sá, Yanna Queiroz Pereira de

; Naves, Luciana Ansaneli

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230391

Abstract: En | Text: En | PDF: En

ABSTRACT Objective Determining the etiology of hyperprolactinemia is fundamental for selecting the most appropriate treatment strategy. The aim of this study was to evaluate the usefulness and accuracy of prolactin levels in predicting the etiology of nonphysiological hyperprolactinemia. Subjects and methods In this retrospective study, we reviewed medical records of patients with nonphysiological hyperprolactinemia seen at two neuroendocrine reference centers located in Recife, Brazil, from January 2000 to December 2019. Results The study included 770 patients aged 12-73 years (65% female). The three most frequent etiologies of hyperprolactinemia were prolactinomas (n = 263; 34.2%), drug-induced hyperprolactinemia (n = 160; 20.8%), and macroprolactinemia (n = 120; 15.6%). The highest mean prolactin levels were observed in cases of prolactinomas and idiopathic hyperprolactinemia. Most patients with hyperprolactinemia due to other etiologies had prolactin levels < 100 ng/mL, but these levels were also found in 16.5% of patients with microproplactinomas and in 20% of those with idiopathic hyperprolactinemia. Likewise, prolactin levels largely overlapped among patients with microprolactinomas, macroprolactinemia, and drug-induced hyperprolactinemia. Notably, prolactin levels > 250 ng/mL enabled a clear distinction between the etiologies of macroprolactinoma and nonfunctioning pituitary adenoma. Moreover, prolactin levels > 500 ng/mL were highly suggestive of macroprolactinomas, although they were also found in very few patients (<2%) with microprolactinomas or drug-induced hyperprolactinemia. Conclusion Despite considerable overlap in prolactin levels among the different etiologies of hyperprolactinemia, values > 250 ng/mL allowed a clear distinction between macroprolactinomas and nonfunctioning pituitary adenomas. Furthermore, prolactin levels > 500 ng/mL were almost exclusively found in patients with prolactinomas. strategy Recife Brazil 200 2019 77 1273 12 73 12-7 65% 65 (65 female. female . female) n 263 34.2%, 342 34.2% , 34 2 34.2%) druginduced drug induced 160 20.8%, 208 20.8% 20 8 20.8%) 120 15.6%. 156 15.6% 15 6 15.6%) 10 ngmL ng mL 165 16 5 16.5 Likewise Notably 25 adenoma Moreover 50 <2% (<2% adenomas Furthermore 201 7 127 1 12- (6 26 34.2 3 20.8 15.6 16. <2 (<2 ( 34. 20. 15. (<

https://doi.org/10.20945/2359-4292-2023-0391

[SciELO Preprints] - Preservation of moderately resistant or tolerant genotypes: a strategy to overcome guava decline
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Silva, Maurício Moisés Pereira Queiróz, Manoel Abilio de Oliveira, Patrícia Gomes Coutinho, Milena dos Santos Mauro da Cunha e Castro, José Mauro da Cunha e Castro

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Publication date: 2023-08-14

Abstract: En Pt

Originária da América Tropical, a goiabeira ( Psidium guajava L. ) tem grande símbolo para o Brasil. Contudo, a evolução do patossistema designado como declínio da goiabeira, problema fitossanitário provocado pelo parasitismo das raízes pelo nematoide-das-galhas ( Meloidogyne enterolobii Yang & Eisenback) em associação com fungos oportunistas, dizimou muitos pomares em todas as regiões do Brasil e em outros países. No presente estudo, propagou-se vegetativamente, por miniestaquia, acessos de goiabeiras seminíferas mantendo seus genótipos preservados e reavaliando a resistência por meio dos clones de forma a comprovar ou não as reações das plantas hospedeiras. Os resultados apontam para alta virulência do parasita, bem como alta hospedabilidade da espécieP. guajava , além da existência de grande variação da reação entre plantas do mesmo genótipo e entre genótipos distintos, o que indica que a estratégia de preservação do germoplasma e a reavaliação da reação em clones pode ser importante na busca e seleção de germoplasma com algum grau de ou resistência de tolerância a M. enterolobii . A progênie da cv. Paluma P02R5R2 obteve uma menor média de Fator de Reprodução do parasita (FR = 22,11) entre os genótipos avaliados, sendo classificado como moderadamente resistente e preservado para estudos posteriores.

Originária da América Tropical, a cultura da goiabeira (Psidium guajava L.) tem grande relevância para o Brasil. Contudo, surgimento do patossistema designado como declínio da goiabeira, problema fitossanitário provocado pelo parasitismo das raízes por nematoides da espécie Meloidogyne enterolobii Yang & Eisenback em associação com fungos oportunistas, dizimou muitos pomares em todas as regiões do Brasil e em outros países. No presente estudo, propagou-se vegetativamente, por miniestaquia, acessos de goiabeiras seminíferas mantendo seus genótipos preservados e reavaliando a resistência por meio dos clones de forma a comprovar ou não as reações das plantas hospedeiras. Os resultados apontam para alta virulência do parasita, bem como alta hospedabilidade da espécie P. guajava, além da existência de grande variação da reação entre plantas do mesmo genótipo e entre genótipos distintos, o que indica que a estratégia de preservação do germoplasma e a reavaliação da reação em clones pode ser importante na busca e seleção de germoplasma com algum grau de resistência ou características de tolerância ao M. enterolobii. A progênie da cv. Paluma P02R5R2 obteve a menor média de Fator de Reprodução do parasita (FR = 22,11) entre os genótipos avaliados, sendo classificada como moderadamente resistente e preservada para estudos posteriores.

https://doi.org/10.1590/SciELOPreprints.4678

Check-All-That-Apply method for sensory characterization of pork from immunocastrated male pigs fed different oil sources
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Silva, Julia Pereira Martins da

; Almeida, Vivian Vezzoni

; Schinckel, Allan Paul

; Meira, Ariana Nascimento

; Moreira, Gabriel Costa Monteiro

; Pian, Laura Woigt

; Campos, Débora de

; Gomes, Julia Dezen

; Gonçales, Janaína Lustosa

; Dargelio, Mariana Damiames Baccarin

; Patinho, Iliani

; Saldaña, Erick

; Contreras-Castillo, Carmen Josefina

; Coutinho, Luiz Lehmann

; Luchiari Filho, Albino

; Nuñez, Amoracyr José Costa

; Cesar, Aline Silva Mello

Scientia Agricola

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2023, Volume 80 elocation e20220019

Abstract: En | Text: En | PDF: En

ABSTRACT In the last decade, other quality attributes have emerged as the main aspects that impact pork consumers acceptance, such as environmentally friendly production, nutritional value, and animal welfare. This study applies a Check-All-That-Apply (CATA) questionnaire for sensory characterization of loins from genetically lean immunocastrated male pigs fed diets containing either a standard commercial diet with 1.5 % soybean oil (control) or 3 % oil from either soybean oil (SO), canola oil (CO), or fish oil (FO) during the growing-finishing phases. Twenty CATA attributes for loin samples were generated. We interviewed 101 consumers to select all the CATA terms that they considered suitable to characterize sensory attributes of longissimus lumborum muscle samples of pigs from each dietary treatment. The CATA results indicated differences among pork loin samples depending on the source and inclusion level of dietary oil. Loins from pigs fed 3 % SO were characterized by a higher frequency of the “juicy texture” attribute (p < 0.05) and a lower frequency of the “dry texture” attribute (p < 0.05) compared to loins from 3 % FO-fed pigs. Moreover, loins from pigs fed 3 % SO had a lower citation frequency of the “tasteless” attribute (p < 0.05) compared to loins from 3 % FO-fed pigs. The attributes “cooked pork meat-like taste”, “juicy texture”, “tender texture”, and “brightness” were placed close to the overall liking. “Tender texture”, “juicy texture”, “pork meat-like” (odor and taste), and “cooked pork meat-like taste” attributes were considered drivers of liking. Feeding genetically lean immunocastrated male pigs with diets containing 3 % SO may be advisable from a pork sensory quality perspective.

https://doi.org/10.1590/1678-992x-2022-0019

Cristianismo no Brasil em perspectiva global
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Coutinho, José Pereira

Religião & Sociedade

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aug 2022, Volume 42 N. 2 Pages 249 - 253

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.1590/0100-85872022v42n2res01

Diretriz Conjunta sobre Tromboembolismo Venoso – 2022
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Albricker, Ana Cristina Lopes

; Freire, Cláudia Maria Vilas

; Santos, Simone Nascimento dos

; Alcantara, Monica Luiza de

; Saleh, Mohamed Hassan

; Cantisano, Armando Luis

; Teodoro, José Aldo Ribeiro

; Porto, Carmen Lucia Lascasas

; Amaral, Salomon Israel do

; Veloso, Orlando Carlos Gloria

; Petisco, Ana Cláudia Gomes Pereira

; Barros, Fanilda Souto

; Barros, Márcio Vinícius Lins de

; Souza, Adriano José de

; Sobreira, Marcone Lima

; Miranda, Robson Barbosa de

; Moraes, Domingos de

; Verrastro, Carlos Gustavo Yuji

; Mançano, Alexandre Dias

; Lima, Ronaldo de Souza Leão

; Muglia, Valdair Francisco

; Matushita, Cristina Sebastião

; Lopes, Rafael Willain

; Coutinho, Artur Martins Novaes

; Pianta, Diego Bromfman

; Santos, Alair Augusto Sarmet Moreira Damas dos

; Naves, Bruno de Lima

; Vieira, Marcelo Luiz Campos

; Rochitte, Carlos Eduardo

Arquivos Brasileiros de Cardiologia

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apr 2022, Volume 118 N. 4 Pages 797 - 857

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20220213

COVID-19 diagnosis by RT-qPCR in alternative specimens
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Gonçalves, Cássia Cristina Alves

; Barroso, Shana Priscila Coutinho

; Herlinger, Alice Laschuk

; Galliez, Rafael de Mello

; de Almeida, Tailah Bernardo

; Boullosa, Lidia Theodoro

; Nascimento, Erica Ramos dos Santos

; de Almeida, Jessica M

; da Costa, Raissa Mirella dos Santos Cunha

; da Paixão, Tatiana Monteiro

; Couceiro, José Nelson dos Santos Silva

; Frauches, Thiago Silva

; de Souza Jr, Wilson Rodrigues

; Costa, Andréa Ribeiro

; Faffe, Débora Souza

; Leitão, Isabela de Carvalho

; da Silva, Bianca Ortiz

; de Lira, Guilherme Sant’Anna

; de Almeida, Isabela Labarba Carvalho

; Ferreira Jr, Orlando da Costa

; Castiñeiras, Terezinha Marta Pereira Pinto

; Mariani, Diana

; Tanuri, Amilcar

Memórias do Instituto Oswaldo Cruz

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2021, Volume 116 elocation e210085

Abstract: En | Text: En | PDF: En

BACKGROUND The high demand for adequate material for the gold standard reverse transcription real-time polymerase chain reaction (RT-qPCR)-based diagnosis imposed by the Coronavirus disease 2019 (COVID-19) pandemic, combined with the inherent contamination risks for healthcare workers during nasopharyngeal swab (NP) sample collection and the discomfort it causes patients, brought the need to identify alternative specimens suitable for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). OBJECTIVES The aim of this work was to compare saliva and gingival fluid swabs to NP swabs as specimens for RT-qPCR-based SARS-CoV-2 diagnosis. METHODS We compared gingival fluid swabs (n = 158) and saliva (n = 207) to the rayon-tipped NP swabs obtained from mild-symptomatic and asymptomatic subjects as specimens for RT-qPCR for SARS-CoV-2 detection. FINDINGS When compared to NP swabs, gingival fluid swabs had a concordance rate of 15.4% among positive samples, zero among inconclusive, and 100% among negative ones. For saliva samples, the concordance rate was 67.6% among positive samples, 42.9% among inconclusive, and 96.8% among negative ones. However, the concordance rate between saliva and NP swabs was higher (96.9%) within samples with lower cycle threshold (Ct) values (Ct > 10 ≤ 25). MAIN CONCLUSIONS Our data suggests that whereas gingival fluid swabs are not substitutes for NP swabs, saliva might be considered whenever NP swabs are not available or recommended.

https://doi.org/10.1590/0074-02760210085 205 downloads

Religiosidade em Portugal: caracterização, comparação e evolução
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Coutinho, José Pereira

Religião & Sociedade

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dec 2019, Volume 39 N. 3 Pages 58 - 81

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: Este artigo tem três objectivos: caracterizar a religiosidade em Portugal, compará-la com os países europeus de matriz católica e analisar a sua evolução. A análise assenta nas bases de dados do ESS, do EVS e do ISSP. Os indicadores da dimensão comunidade são os mais elevados e estão acima da média; os indicadores da dimensão crença são elevados ou médios; os indicadores da dimensão prática são baixos ou médios; os indicadores da dimensão norma são médios e estão próximos da média. Na generalidade, os indicadores parecem estar a decrescer. As crenças não cristãs são baixas e parecem estar a crescer ligeiramente. O tipo praticante parece estar a baixar, mas não a favor do tipo peregrino, pelo menos de forma significativa.

Abstract: This article has three aims: to characterize religiosity in Portugal, to compare it with European countries of Catholic origin, and to analyze its evolution. The analysis is based on ESS, EVS and ISSP databases. Community dimension’s indicators are the highest and above average; belief dimension’s indicators are high or medium; practice dimension’s indicators are low or medium; religious norms dimension’s indicators are medium and close to the average. Overall, these indicators seem to be decreasing. Non-Christian beliefs are low and appear to be growing slightly. The practitioner type seems to be lowering, but not in favor of the pilgrim type, at least significantly.

https://doi.org/10.1590/0100-85872019v39n3cap03 2510 downloads

RELIGIOSIDADE DA JUVENTUDE PORTUGUESA : Evolução recente e comparação com o restante da população
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Coutinho, José Pereira

Revista Brasileira de Ciências Sociais

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2019, Volume 34 N. 101 elocation e3410114

Abstract: Pt En Fr | Text: Pt En Fr | PDF: Pt | PDF: En | PDF: Fr

Este artigo, baseado no European Values Study, European Social Survey e International Social Survey Programme, discute a evolução da religiosidade juvenil portuguesa no período 1990-2016, comparando com o restante da população, assente em quatro dimensões: comunidade, crença, prática e norma. As dimensões “comunidade”, “prática” e “norma” decrescem, embora a “prática” possa estar estabilizada. A dimensão “crença”, cristã e não cristã, cresce ou mantém-se. As dimensões “comunidade”, “prática” e “norma” são menores nos jovens, enquanto a dimensão “crença”, cristã e não cristã, é maior ou igual nos jovens. O artigo contribui para analisar a religiosidade juvenil em Portugal de forma mais exaustiva do que se encontra atualmente feito.

This paper, based on the European Values Study, European Social Survey and International Social Survey Programme, discusses the evolution of Portuguese youth religiosity in the period between 1990 and 2016, comparing it with the population aged 29 or older, based on four topics: community, belief, practice and norm. The topics “community”, “practice”, and “norm” decrease, although “practice” may be stabilized. The topic “belief”, Christian and non-Christian, increases or keeps the same value. The topics “community”, “practice” and “norm” are less representative in young people, while the topic “belief”, Christian or non-Christian, is more or equally representative in young people. The paper contributes in the analysis of the youth religiosity in Portugal in a more comprehensive way than it is currently done.

Cet article, basé sur l’European Values Study, l’European Social Survey et l’International Social Survey Programme, traite de l’évolution de la religiosité juvénile portugaise au cours de la période 1990-2016, par rapport à la population de plus de 29 ans, sur la base de quatre dimensions: Communauté, croyance, pratique et norme. Les dimensions «communauté», «pratique» et «norme» diminuent, bien que la «pratique» puisse être stabilisée. La dimension «croyance», chrétienne et non-chrétienne, augmente ou se maintient. Les dimensions «communauté», «pratique» et «norme» sont moins importantes chez les jeunes, tandis que la dimension «croyance», chrétienne et non-chrétienne, est plus grande ou égale chez les jeunes. L’article contribue à analyser la religiosité juvénile au Portugal de manière plus exhaustive qu’actuellement.

https://doi.org/10.1590/3410114/2019 533 downloads

10.

Soil quality and soybean productivity in crop-livestock integrated system in no-tillage
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Laroca, Jackeline Vieira dos Santos

; Souza, Juliana Mendes Andrade de

; Pires, Gabriela Castro

; Pires, Gleidson José Coutinho

; Pacheco, Leandro Pereira

; Silva, Francine Damian da

; Wruck, Flávio Jesus

; Carneiro, Marco Aurélio Carbone

; Silva, Laércio Santos

; Souza, Edicarlos Damacena de

Pesquisa Agropecuária Brasileira

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nov 2018, Volume 53 N. 11 Pages 1248 - 1258

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar a qualidade do solo e sua relação com a produtividade de soja (Glycine max) em sistema de integração lavoura-pecuária (ILP), com consórcio entre gramíneas e leguminosas na fase pastagem. O experimento foi realizado no Estado de Mato Grosso, em um Latossolo Vermelho distrófico, em que gramíneas (Megathyrsus maximus 'BRS Tamani' e Urochloa brizantha 'BRS Piatã'), consorciadas com feijão-caupi (Vigna unguiculata 'BRS Tumucumaque') e feijão-guandu (Cajanus cajan 'BRS Mandarim'), foram cultivadas após a colheita da soja. Um delineamento experimental de blocos ao acaso foi utilizado com três repetições, em arranjo de parcelas subdivididas, em que as gramíneas foram consideradas como parcelas, e as leguminosas, como subparcelas. Os consórcios com leguminosas proporcionaram incrementos dos estoques de C e N total. Os consórcios causaram o aumento de C e N da biomassa microbiana, enquanto os cultivos solteiros contribuíram para o estresse da microbiota do solo. A atividade da enzima urease foi sensível às alterações de manejo em curto prazo, porém a fosfatase ácida e a β-glucosidase foram indicadores pouco sensíveis. A qualidade do solo é elevada com os consórcios entre gramíneas e leguminosas, com efeitos positivos sobre a produtividade de grãos de soja.

Abstract: The objective of this work was to evaluate the quality of the soil and its relation with soybean (Glycine max) yield in an integrated crop-livestock system (ICLS), with intercropping between grasses and legumes in the pasture phase. The experiment was carried out in the state of Mato Grosso, Brazil, on a dystrophic Oxisol, in which grasses (Megathyrsus maximus 'BRS Tamani' and Urochloa brizantha 'BRS Piatã'), intercropped with cowpea (Vigna unguiculata 'BRS Tumucumaque') and pigeon pea (Cajanus cajan 'BRS Mandarim'), were cultivated after soybean harvest. A randomized complete block design was used, with three replicates, in a split-plot arrangement, in which grasses were considered as plots, and legumes as subplots. Legume intercrops provided increases of C and total N stocks. The intercrops caused the increase of C and N of the microbial biomass, whereas the single cultures contributed to stress in the soil microbiota. The activity of the urease enzyme was sensitive to management changes in the short term, but acid phosphatase and β-glucosidase were poorly sensitive indicators. Soil quality is high with intercropping between grasses and legumes, with positive effects on soybean grain yield.

https://doi.org/10.1590/s0100-204x2018001100007 1725 downloads

11.

Restrição à Liberdade Religiosa no Mundo: Caracterização de Clusters e Definição de Modelos Explicativos
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Coutinho, José Pereira

Dados

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sep 2018, Volume 61 N. 3 Pages 617 - 657

RESUMO Este artigo tem dois objetivos. Primeiro: define-se e caracteriza-se clusters de restrição à liberdade religiosa (ou restrição religiosa), a nível mundial, assente em fatores religiosos, culturais, políticos, económicos, sociais e demográficos. Segundo: desenvolve-se três modelos explicativos da restrição religiosa, assentes nestes factores. A análise baseia-se no Pew Research Center, tanto nos dados das restrições governamentais e das hostilidades sociais, como nos seus quatro grupos (baixo, moderado, elevado e muito elevado). O principal factor explicativo da restrição religiosa é a percentagem de cristãos não ortodoxos, a mais importante nos três modelos, acrescido da dimensão populacional, liberdade, fraccionamento religioso e minoria muçulmana, cuja importância varia por modelo.

ABSTRACT This article has two goals. First, clusters of restrictions on religious freedom (or religious restraint) are defined and characterized worldwide, based on religious, cultural, political, economic, social and demographic factors. Second, three explanatory models of religious restraint are developed, based on these factors. The analysis is based on the Pew Research Center, both in terms of government restrictions and social hostilities, and in its four groups (low, moderate, high and very high). The main explanatory factor of religious restraint is the percentage of unorthodox Christians, the most important in all three models, plus the population size, freedom, religious fractionation and Muslim minority, whose importance varies by model.

RESUMEN El artículo tiene dos objetivos. En primer lugar, son definidos y caracterizados clusters de restricción a la libertad religiosa (o restricción religiosa), a nivel mundial, basada en factores religiosos, culturales, políticos, económicos, sociales y demográficos. En segundo: se desarrollan tres modelos explicativos de la restricción religiosa, basados en estos factores. El análisis se basa en el Pew Research Center, tanto en los datos de las restricciones gubernamentales y de las hostilidades sociales, como en sus cuatro grupos (bajo, moderado, elevado y muy elevado). El principal factor explicativo de la restricción religiosa es el porcentaje de cristianos no ortodoxos (factor más importante en los tres modelos), sumándose a: la dimensión de la población, la libertad, el fraccionamiento religioso y la minoría musulmana, cuya importancia varía según el modelo.

RÉSUMÉ Cet article a deux objectifs. D’abord, sont définis et caractérisés des clusters de restrictions à la liberté religieuse (ou à la contrainte religieuse), fondés sur des facteurs religieux, culturels, politiques, économiques, sociaux et démographiques. Deuxièmement, trois modèles explicatifs de la contrainte religieuse sont développés sur la base de ces facteurs. L’analyse est basée sur le Pew Research Center, à la fois en termes de restrictions gouvernementales et de hostilités sociales, et dans ses quatre groupes (faible, modéré, élevé et très élevé). Le principal facteur explicatif de la contrainte religieuse est le pourcentage de chrétiens non orthodoxes, le plus important dans les trois modèles, ainsi que la taille de la population, la liberté, le fractionnement religieux et la minorité musulmane, dont l’importance varie selon le modèle.

https://doi.org/10.1590/001152582018169 5967 downloads

12.

Effectiveness of first-wave protease inhibitors in hepatitis C virus genotype 1 infection: a multicenter study in Brazil
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Lobato, Cirley Maria de Oliveira

; Balassiano, Natalia

; Hyppolito, Elodie Bomfim

; Sanchez-Lermen, Rafaela Liz Pellegrim

; Signorelli, Izabelle Venturini

; Nicacio, Miguel Yasuo Tomita

; Firmino Filho, Alberto Pereira

; Andrade, Thais Guaraná de

; Lima, José Milton de Castro

; Arruda, Talita Amorim de

; Coutinho, Fernanda Schwanz

; Araujo, Everton Felipe do Vale

; Esmeraldo, Ticiana Mota

; Cortez, Erlon

; Capeli, Rafaela Lorenzon Aragão

; Matos, Melquior Brunno Mateus de

; Pessoa, Francisco Sérgio Rangel

; Oliveira, Hélder Cássio de

; Arruda, Érico Antônio Gomes de

; Gonçalves, Patrícia Lofêgo

; Araújo Filho, Antônio Haroldo

; Esberard, Eliane Bordalo Cathalá

; Souto, Francisco José Dutra

Revista da Sociedade Brasileira de Medicina Tropical

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feb 2018, Volume 51 N. 1 Pages 14 - 20

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: In 2013, combination therapy using peginterferon, ribavirin, and boceprevir or telaprevir was introduced to treat hepatitis C virus genotype 1 infection in Brazil. The effectiveness of this therapy in four Brazilian regions was evaluated. METHODS: Clinical and virological data were obtained from patients of public health institutions in five cities, including sustained virological response (SVR) and side effects. Patients with advanced fibrosis (F3/4), moderate fibrosis (F2) for > 3 years, or extra-hepatic manifestations were treated according to Ministry of Health protocol. Treatment effectiveness was verified by using bivariate and multivariate analysis; p-values of < 0.05 were considered significant. RESULTS: Of 275 patients (64.7% men; average age, 57 years old), most (61.8%) were treatment-experienced; 53.9% had subgenotype 1a infection, 85.1% had advanced fibrosis, and 85.5% were treated with telaprevir. SVR was observed in 54.2%. Rapid virological response (RVR) was observed in 54.6% of patients (data available for 251 patients). Overall, 87.5% reported side effects and 42.5% did not complete treatment. Skin rash, severe infection, and death occurred in 17.8%, 2.5%, and death in 1.4% of cases, respectively. SVR was associated with treatment completion, RVR, and anemia. CONCLUSIONS: The effectiveness of hepatitis C virus triple therapy was lower than that reported in phase III clinical trials, possibly owing to the prioritized treatment of patients with advanced liver fibrosis. The high frequency of side effects and treatment interruptions observed supported the decision of the Brazilian authorities to suspend its use when safer and more effective drugs became available in 2015.

https://doi.org/10.1590/0037-8682-0279-2017 1312 downloads

13.

Characterization of the Capibaribe River Dry Bed with Ground Penetrating Radar (GPR)
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Brito, Gracieli Louise Monteiro

; Coutinho, Artur Paiva

; Cabral, Jaime Joaquim da Silva Pereira

; Santos Neto, Severino Martins dos

; Antonino, Antonio Celso Dantas

; Cirilo, José Almir

; Braga, Ricardo Augusto Pessoa

; Silva Filho, Severino Lopes da

RBRH

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2018, Volume 23 elocation e1

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Para um estudo hidrogeológico adequado de camadas de aluvião no semiárido é importante conhecer bem sua geometria e suas propriedades. As formações aluviais são geralmente constituídas por processos de erosão, transporte e sedimentação, causando considerável heterogeneidade nos parâmetros hidráulicos do solo e no fluxo de água. A presente pesquisa teve como objetivo realizar uma caracterização geofísica através do Radar de Penetração no Solo – GPR no leito seco do rio Capibaribe. As mudanças nas camadas no conteúdo de água, granulometria, tipo de sedimento e orientação das camadas, o lençol freático, as estruturas sedimentares e os contatos litológicos tendem ser identificados, o que torna o método eficaz para investigação hidrogeológica. A área de estudo compreende as aluviões do leito seco do alto Capibaribe no município de Santa Cruz do Capibaribe. Os resultados mostraram que o GPR foi eficiente no imageamento da subsuperficie contribuindo para o conhecimento da geometria e da estratigrafia do aquífero do leito. No leito seco do rio, com antena de 400 MHz o sinal atingiu profundidade de 2,65 m e com antena de 200 MHz o sinal atingiu 6,00 m. A franja capilar foi identificada na profundidade de 3,0 m com o uso das antenas de 200MHz e 400MHz.

ABSTRACT For an adequate hydrogeological study of alluvial layers in the semi-arid zone, it is important to know well its geometry and its hydraulics characteristics. Alluvial formations are generally constituted by erosion, transport and sedimentation processes, causing considerable heterogeneity in soil hydraulic parameters and water flow. The present research had as objective to perform a geophysical characterization using the Ground Penetrating Radar – GPR in the dry bed of the Capibaribe river. To the extent that depositional layers exhibit changes in water content, granularity, sediment type and layer orientation, the water table as well as sedimentary structures and lithological contacts tend to be identified, making the method effective for hydrogeology research. The study area comprises alluvial dry river bed of upper Capibaribe river in the municipality of Santa Cruz do Capibaribe. The results showed that GPR was efficient in the imaging of the subsurface contributing to the knowledge of the geometry and the stratigraphy of the aquifer of the dry bed of the river. In the dry bed of the river, with 400 MHz antenna the signal reached a depth of 2.65 m, and with the antenna of 200 MHz, the signal reached a depth of 6.00 m. The capillary fringe was identified at a depth of 3.0m with the use of 200MHz and 400MHz antennas.

https://doi.org/10.1590/2318-0331.0318170023 2339 downloads

14.

Comparison between single port videolaparoscopy and miniceliotomy with snock hook ovariohysterectomy techniques in bitches
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Coutinho, Alexandre José

; Gasser, Beatriz

; Rodriguez, Mariana Garcia Kako

; Uscategui, Ricardo Andres Ramirez

; Santos, Victor José Correia

; Tiosso, Caio de Faria

; Barros, Felipe Farias Pereira da Câmara

; Toniollo, Gilson Hélio

Ciência Rural

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2018, Volume 48 N. 10 elocation e20180345

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: Com o intuito de utilizar e estudar técnicas minimamente invasivas que permitam reduzir os efeitos adversos da ovário-histerectomia (OVH) em cadelas objetivou-se comparar: o tempo, as complicações cirúrgicas, a dor e a resposta inflamatória pós-operatória, resultantes da OVH laparoscópica por único portal e a miniceliotomia tradicional com gancho de Snook. Vinte e quatro cadelas hígidas foram aleatoriamente divididas em dois grupos e realizadas a OVH por videolaparoscopia (Vídeo) ou miniceliotomia (MiniLap). Avaliaram-se e compararam-se estatisticamente: o tempo e intercorrências cirúrgicas, a dor, necessidade de resgate analgésico, concentração sérica de proteína C reativa, glicemia e o consumo voluntário de alimento durante as 24 horas subsequentes ao procedimento. O tempo operatório (38±7min), as intercorrências cirúrgicas (17%), a intensidade de dor pós-operatória, a necessidade de resgate analgésico e a concentração sérica de proteína C reativa foram similares entre os grupos (P>0,05). A glicemia foi menor nos animais do grupo Vídeo (P=0,03) e estes se alimentaram mais rapidamente e em maior proporção (P=0,02). Assim, conclui-se que as técnicas de OVH por videolaparoscopia, miniceliotomia resultam em complicações, tempos cirúrgicos e respostas inflamatórias similares, no entanto, os animais submetidos à videolaparoscopia se alimentam mais prontamente e apresentam menor índice glicêmico indicando um nível de estresse menor e este resultado considera-se válido para a indicação desta técnica.

ABSTRACT: In order to use and study minimally invasive techniques to reduce side effects of ovarian-hysterectomy (OHE) in bitches, the aim of this study was to compare time, surgical complications, pain and postoperative inflammatory response, caused by single port videolaparoscopic OHE and traditional miniceliotomy with snook hook. Twenty-four healthy bitches were randomly divided in two groups: videolaparoscopy (Video) and miniceliotomy (MiniLap). Surgical time and complications, pain, need for analgesic rescue, C-reactive protein concentration, glycaemia and voluntary food ingestion were evaluated during 24 hours following the procedure and compared statistically. Surgical time (38±7min), surgical complications (17%), postoperative pain intensity, need for analgesic rescue and C-reactive protein concentration were similar between groups (P>0.05). Glycaemia was lower in Video group (P=0.03), animals fed faster and in greater proportion (P=0.02). Thus, it is concluded that both OHE techniques result in similar complications, surgical time and inflammatory response; however, animals on Video group fed more readily and presented lower glycaemia, which point to lower stress levels. These findings validated the indication of this technique.

https://doi.org/10.1590/0103-8478cr20180345 882 downloads

15.

Mudanças Culturais, Mudanças Religiosas: Perfis e Tendências da Religiosidade em Portugal Numa Perspetiva Comparada
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Coutinho, José Pereira

Sociologia, Problemas e Práticas

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sep 2016, N. 82 Pages 171 - 174

Abstract: Pt | Text: Pt | PDF: Pt

https://doi.org/10.7458/SPP2016827404 849 downloads

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