Resumo Lafoensia pacari é empregada na medicina tradicional no cerrado Brasileiro para tratar feridas. É importante desenvolver estudos para melhor compreender como ocorre a atividade biológica de L. pacari . O objetivo deste estudo foi avaliar a atividade cicatrizante do extrato das folhas de L. pacari em modelo animal. O extrato vegetal foi preparado a partir de plantas oriundas de Goiânia-GO, Brasil. Na avaliação da atividade cicatrizante, foi empregado o modelo de feridas cutâneas em ratos. Análise macroscópica, morfométrica e histológica das feridas também foram realizadas. Na cromatografia de camada delgada foi detectada a presença de taninos hidrolisáveis e na cromatografia líquida de alta eficiência, pôde-se sugerir a presença de elagitaninos. Na avaliação das feridas cutâneas em ratos foi possível observar que o tratamento com extrato de L. pacari a 10% (m/v) proporcionou uma redução no tempo de cicatrização de feridas cutâneas em ratos, com aumento significativo das variáveis envolvidas na cicatrização, como número de vasos sanguíneos e a produção de colágeno. Portanto, este estudo mostra que o potencial cicatrizante de L. pacari pode estar relacionado à presença de elagitaninos, o que corrobora com relatos etnofarmacológicos deste vegetal.

Abstract Lafoensia pacari has been used in traditional folk medicine in Brazilian Cerrado to treat wounds. It is important to develop studies that can clarify how the biological activity of L. pacari occurs. The aim of this study was to evaluate the healing activity of L. pacari leaves extract in an animal model. The extract was prepared from plants cultivated in Goiania-GO, Brazil. The healing activity was assayed using cutaneous wound model in rats, and macroscopic, morphometric and histological analysis of wounds were also conducted. The presence of hydrolysable tannins was detected in thin layer chromatography and in high performance liquid chromatography analysis, may be suggested the presence of ellagitannins. In the evaluation of cutaneous wounds in rats it was possible to observe that the treatment with 10% (w/v) L. pacari extract provided a reduction in the time of cutaneous wound healing, with a significant increase in variables involved in healing, such as the number of blood vessels and collagen production. Therefore, this study shows that L. pacari wound healing potential may be related to the presence of ellagitannins and corroborates to ethnopharmacological reports regarding this plant.

RESUMO Racional: A CPRE está associada a complicações, que podem ser prevenidas pelo reconhecimento de fatores de risco. Objetivo: Identificar tais fatores em nosso meio, com avaliação de qualidade. Métodos: Estudo retrospectivo em 194 pacientes de um hospital brasileiro, excluindo-se anatomia cirurgicamente alterada. Resultados: Executaram-se 211 CPREs: 97.6% foram terapêuticas, 83.4% iniciadas pelos residentes, com 89.6% de taxa de canulação profunda. Pré-corte foi necessário em 16.6% das CPREs e papilotomia clássica em 67.3%, com esvaziamento ductal de 74.5% em única sessão e 8.0% de falha técnica. Papilas inacessíveis ocorreram em 2.5% dos casos. Houve complicações tardias (2.5%) e precoces (16%). Em análise multivariada, identificaram-se seis preditores para complicações precoces: fistulotomia (RC=3.4, p=0.010), canulação difícil (RC=21.5, p=0.002), tempo do preceptor no procedimento (RC=2.4, p=0.020), coledocolitíase (RC ajustada=1.8, p=0.015), tempo de canulação (RC ajustada=3.2, p=0.018) e duração da CPRE (RC ajustada=2.7, p=0.041). Conclusão: Identificaram-se seis fatores para complicações pós-CPRE, sugerindo-se duração da CPRE e tempo de canulação como novos potenciais indicadores de qualidade.

ABSTRACT Background: ERCP can lead to complications, which can be prevented by the recognition of risk factors. Aim: To identify these risk factors, with quality evaluation. Methods: Retrospective study in a Brazilian hospital in 194 patients, excluding surgically altered anatomy. Results: 211 ERCPs were performed: 97.6% were therapeutic, 83.4% were started by trainees, with deep cannulation rate of 89.6%. Precut was needed in 16.6% of the ERCPs and classic sphincterotomy in 67.3%, with 75.4% of ductal clearance at single session and 8.0% of technical failure. Inacessible papillas ocurred in 2.5% of cases. There were 2.5% of late complications and 16% of early complications. Multivariate analysis identified six predictors for early complications: fistulotomy precut (OR=3.4, p=0.010), difficult cannulation (OR=21.5, p=0.002), attending’s procedural time (OR=2.4, p=0.020), choledocholithiasis (adjusted OR=1.8, p=0.015), cannulation time (adjusted OR=3.2, p=0.018) and ERCP duration (adjusted OR=2.7, p=0.041). Conclusion: Six risk factors for post-ERCP complications were identified. ERCP duration and cannulation time are suggested as new potential quality indicators.

Abstract Background Accumulation of abdominal adiposity (AA) constitutes a risk factor for heart and coronary diseases and for metabolic complications. Research suggests that stress is related to adipogenesis. The burnout syndrome (BS) is linked to stress due to the chronicity of work stress. The objective of this study is to estimate the association between BS and AA in Primary Health Care (PHC) nursing practitioners. Methods This is confirmatory cross-sectional study with 189 workers from nine municipalities in Bahia, Brazil. The dependent variable was AA, measured by waist circumference. The independent variable was the BS, diagnosed by the Maslach Burnout Inventory (MBI). Sociodemographic and job characteristics, lifestyle, and human biology were taken as covariates and were evaluated as modifiers or confounders by the homogeneity tests and by comparison with the adjusted Mantel-Haenszel test, respectively. Logistic regression was employed to evaluate the association between BS and AA, adjusted for covariates. The adequacy of the final regression model was evaluated by the model’s goodness of fit test and the area under the ROC curve. Results BS prevalence was 10.6% and AA 54%. The variables age, education, hypertension, diabetes, working time, and high emotional exhaustion were associated with AA. An association was found between BS and AA (1.63 adjusted prevalence ratios; 95% CI, 1.29 to 2.06) even after age and working time adjustment. Conclusion The results suggest an association between BS and AA in the analyzed professionals. A significant prevalence of burnout and AA is highlighted.

This cross-sectional retrospective study evaluated 440 leprosy patients; 57% (251/440) had leprosy reactions during and/or after multidrug therapy, 80.5% (202/251) of whom presented with multibacillary leprosy. At diagnosis, positive bacterial index (BI) [odds ratio (OR) = 6.39; 95% confidence interval (CI): 4.1-10.1)] or polymerase chain reaction (PCR) (OR = 9.15; 95% CI: 5.4-15.5) in skin smears, anti-phenolic glycolipid-1 (anti-PGL-1) ELISA (OR = 4.77; 95% CI: 2.9-7.9), leucocytosis (OR = 9.97; 95% CI: 3.9-25.7), thrombocytopenia (OR = 5.72; 95% CI: 2.3-14.0) and elevated lactate dehydrogenase (OR = 2.38; 95% CI: 1.4-4.0) were potential markers for the development of reactions during treatment. After treatment, positive BI (OR = 8.47; 95% CI: 4.7-15.3) and PCR (OR = 6.46; 95% CI: 3.4-12.3) in skin smears, anti-PGL-1 ELISA (OR = 2.25; 95% CI: 1.3-3.9), anaemia (OR = 2.36; 95% CI: 1.2-4.5), leucocytosis (OR = 4.14; 95% CI: 1.5-11.6) and thrombocytopenia (OR = 3.70; 95% CI: 1.3-2.2) were risk factors for the occurrence of reactions during the study period. The identification of groups with an increased risk for developing reactions will allow for the timely development of a treatment plan to prevent nerve damage and, therefore, the appearance of the disabling sequelae associated with the stigma of leprosy.

Classification of biodiesel by oilseed type using pattern recognition techniques is described. The spectra of the samples were performed in the Visible region, requiring noise removal by use of a first derivative by the Savitzky-Golay method, employing a second-order polynomial and a window of 21 points. The characterization of biodiesel was performed using HCA, PCA and SIMCA. For HCA and PCA methods, one can observe the separation of each group of biodiesel in a spectral region of 405-500 nm. SIMCA model was used in a test group composed of 28 spectral measurements and no errors are obtained.

RESUMO O presente estudo teve por objetivo conhecer a estrutura fitossociológica da vegetação arbustivoarbórea colonizadora em um plantio, abandonado há 50 anos, de Eucalyptus spp., no Município de Lavras, MG, visando diagnosticar a existência de grupos de espécies, de gradientes vegetacionais e a diversidade alpha. A amostragem fitossociológica, realizada pelo método dos quadrantes, contou com 100 pontos, distribuídos em seis transecções de comprimentos variáveis. Estiveram passíveis de inclusão todos os indivíduos com diâmetro a altura do peito (DAP) (≥5 cm). O levantamento resultou em uma densidade de 854,28 indivíduos/ha, com 91 espécies, distribuídas em 67 gêneros e 31 famílias. Destacaram-se, em valor de importância, Piptadenia gonoacantha, Copaifera langsdorffii, Tapirira guianensis e Ocotea corymbosa. A análise da distribuição dos indivíduos em classes de diâmetro revelou uma comunidade em plena regeneração. A maioria das espécies apresentou síndromes de dispersão zoocórica, sugerindo que o plantio pode ter servido de abrigo e refúgio para espécies da fauna dispersora presente na região. As guildas de regeneração mais frequentes foram as de pioneiras e clímax exigentes de luz, possivelmente em função da mortalidade de indivíduos de Eucalyptus spp., que ocasionou clareiras de diferentes tamanhos. Foi diagnosticado um gradiente vegetacional longo, com uma mudança gradativa na equabilidade entre os quatro grupos de espécies caracterizados pela análise de agrupamento. Os índices de diversidade (H’ = 3,58) e equabilidade (J = 0,794) de espécies foram semelhantes aos encontrados em outros levantamentos fitossociológicos, em plantios de Eucaliptus spp.. Dessa forma, o plantio funcionou como um catalisador da regeneração natural na área de estudo. 5 anos spp spp. Lavras MG alpha quadrantes 10 pontos variáveis DAP (DAP ≥5 (≥ cm. cm . cm) 85428 854 28 854,2 indivíduosha ha indivíduos/ha 9 6 3 famílias Destacaramse, Destacaramse Destacaram se, se Destacaram-se importância gonoacantha langsdorffii corymbosa zoocórica região luz tamanhos longo agrupamento H (H 3,58 358 58 J 0,794 0794 0 794 fitossociológicos forma 1 ≥ ( 8542 85 2 854, 3,5 35 0,79 079 79 8 3, 0,7 07 7 0,

ABSTRACT The objective of this work was to study the phyto-sociological structure of a shrub and tree vegetation colonization in an abandoned stand of Eucalyptus spp. in Lavras, MG, Brazil, in order to identify the existence of species groups, vegetation gradients, and Alpha diversity. The phytosociological sampling collected 5 transects of various sizes with 100 equidistant points (14 m), using the quadrant method. The assessment included all individuals with breast diameter ≥5 cm. There were a total of 854.28 sampled individuals/ha, belonging to 91 species, distributed into 67 genera and 31 families. The highest VI values were obtained for Piptadenia gonoacantha, Copaifera langsdorffii, Tapirira guianensis and Ocotea corymbosa. The analysis of trunk diameter distribution showed that the community was in a stage of full regeneration with individuals distributed over all diameter classes. Most species presented syndromes of seed dispersal by animals and regeneration guilds of pioneer and climax demanding light. Perhaps planting may have served as shelter and refuge for fauna species in the region and mortality of individuals of Eucalyptus spp. resulted in gaps of different sizes. Vegetation was identified along a gradient, with a gradual change in evenness between the four groups of species characterized by cluster analysis. The indices of diversity (H’ = 3.58) and evenness (J = 0.794) of the species were similar to those found in other phyto-sociological studies of Eucaliptus spp platations. Furthermore, the tree planting functioned as a catalyst for natural regeneration in the study area. phyto sociological Lavras MG Brazil gradients 10 14 (1 m, m , m) method ≥ cm 85428 854 28 854.2 individualsha ha individuals/ha 9 6 3 families gonoacantha langsdorffii corymbosa classes light gradient H (H 3.58 358 58 J 0.794 0794 0 794 platations Furthermore area 1 ( 8542 85 2 854. 3.5 35 0.79 079 79 8 3. 0.7 07 7 0.

A eimeriose é responsável por causar graves problemas avícolas caracterizados, principalmente, por redução do ganho de peso e alteração na conversão alimentar, gerando grandes perdas econômicas. O objetivo deste trabalho foi avaliar a epidemiologia da eimeriose em frangos de corte na região de Araguaína, Estado do Tocantins, Brasil. Amostras de cinco propriedades foram colhidas e encaminhadas ao Laboratório de Higiene e Saúde Pública da Escola de Medicina Veterinária e Zootecnia da Universidade Federal do Tocantins. Após análise parasitológica, comprovou-se que todas as propriedades avaliadas apresentaram positividade para espécies do gênero Eimeria, tendo 63,1% dos galpões positivos, sendo encontrados oocistos de E. maxima, E. acervulina, E. mitis e E. tenella. Conclui-se que todas as propriedades avaliadas, apresentaram positividade para quatro espécies do gênero Eimeria comprovando que as estratégias sanitárias adotadas nas criações apresentam falhas que possibilitam a disseminação do patógeno nos lotes avícolas.

Eimeriosis is responsible for causing serious problems in poultry, mainly characterized by reduced weight gain and abnormalities of food conversion efficiency, thereby causing great economic losses. The aim of this study was to evaluate the epidemiology of eimeriosis in broiler chickens in the Araguaina region, State of Tocantins, Brazil. Samples from five farm properties were collected and sent to the Hygiene and Public Health Laboratory, School of Veterinary Medicine and Zootechnics, Federal University of Tocantins. From the parasitological analysis, it was shown that all the properties examined were positive for Eimeria species. 63.1% of the sheds were positive, with findings of oocysts of E. maxima, E. acervulina, E. mitis and E. tenella. It was concluded that all properties evaluated were positive for four species of the genus Eimeria, thus demonstrating that the sanitary strategies followed in poultry rearing had flaws that allowed pathogens to spread in poultry pens.