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Microparticulated whey protein can be used as a fat substitute in foods to enhance their nutritional value and improve their sensory and rheological characteristics. Microparticulation denatures whey proteins through heat treatment, followed by shear rate control to determine the aggregate sizes formed. The processing method used during microparticulation can modify the protein denaturation rate, which may enable the application of new proteins. This study sought to develop a methodology for quantifying whey protein fractions in commercial samples before and after microparticulation at different concentrations and physical states. The developed methodology proved to be applicable because of its selectivity, quantification, detection limits, and precision. The analyzed samples exhibited a higher denaturation rate for β-lactoglobulin than α-lactoalbumin; the denaturation rate varied among samples due to differences in the microparticulation process. characteristics treatment formed states selectivity quantification limits precision βlactoglobulin β lactoglobulin αlactoalbumin α lactoalbumin α-lactoalbumin process

https://doi.org/10.21577/0100-4042.20250038

Physiology, biochemistry and yield of melon in a semi-arid region with the application of biostimulants Physiology semiarid semi arid
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Farias, Raul M. de

; Grangeiro, Leilson C.

; Sousa, Valdívia de F. L. de

; Morais, Éric G.

; Oliveira, Renata R. T.

; Pereira, Dalbert de F.

; Souza, Bruna de P.

; Carmo, Luiz H. de A.

; Paiva, Laíza G. de

; Medeiros, Gerson B. F. de

; Sousa, Lucas M. da S.

; Costa, Romualdo M. C.

Revista Brasileira de Engenharia Agrícola e Ambiental

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2025, Volume 29 N. 1 elocation e283055

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Regiões com climas semiáridos apresentam condições ambientais que resultam em estresses abióticos às plantas. A maior área de produção de melão (Cucumis melo L.) do Brasil, o Estado do Rio Grande do Norte, possui essas características climáticas. O uso de bioestimulantes nesses sistemas de produção pode mitigar os efeitos dos estresses abióticos e aumentar a produtividade e a qualidade dos frutos. O objetivo neste estudo foi avaliar as características fisiológicas e de produção do meloeiro, sob aplicação de bioestimulantes. Os bioestimulantes Acadian®, Folicist® e Nov@® foram aplicados e comparados ao tratamento controle (sem bioestimulantes), em melões ‘Goldex’ e ‘McLaren’. Nov@® proporcionou maior assimilação de CO2, transpiração e condutância estomática, assim como ascorbato peroxidase em ‘Goldex’ e ‘McLaren’. Maior catalase foi obtida pela aplicação de Nov@®, enquanto que o uso de Folicist® resultou em maior teor de malondialdeído. A cultivar McLaren apresentou o melhor desempenho fisiológico e bioquímico e a ‘Goldex’ o melhor rendimento. Folicist® promove adaptações fisiológicas aos estresses sem prejudicar a atividade fotossintética. Os bioestimulantes aumentaram a produtividade e o número de frutos por planta e promoveram adaptações fisiológicas às condições semiáridas. plantas Cucumis L. L Brasil Norte climáticas meloeiro Acadian Acadian® Folicist Nov Nov@ bioestimulantes, , bioestimulantes) ‘Goldex Goldex ‘McLaren. ‘McLaren . ‘McLaren’ CO2 CO estomática malondialdeído rendimento fotossintética semiáridas

ABSTRACT Regions with semi-arid climates have environmental conditions that result in abiotic stress to plants. The largest melon (Cucumis melo L.) production area in Brazil, the state of Rio Grande do Norte, has these climatic characteristics. Use of biostimulants in these production systems can mitigate effects of abiotic stress and increase yield and fruit quality. The objective in this study was to evaluate the physiological and production characteristics of melon, under the application of biostimulants. The biostimulants Acadian®, Folicist® and Nov@® were applied and compared to the control treatment (no biostimulants), in ‘Goldex’ and ‘McLaren’ melons. Nov@® led to higher CO2 assimilation, transpiration and stomatal conductance, as well as ascorbate peroxidase, in ‘Goldex’ and ‘McLaren’. Greater catalase was obtained with the application of Nov@®, while the use of Folicist® resulted in higher malondialdehyde content. The cultivar ‘McLaren’ exhibited the best physiological and biochemical performance, and ‘Goldex’ the best yield. Folicist® promotes physiological adaptations to stress without impairing photosynthetic activity. The biostimulants increased yield and number of fruits per plant and promoted physiological adaptations to semi-arid conditions. semiarid semi arid plants Cucumis L. L Brazil Norte quality Acadian Acadian® Folicist Nov Nov@ no biostimulants, , biostimulants) ‘Goldex Goldex ‘McLaren McLaren melons CO assimilation conductance peroxidase ‘McLaren. . content performance activity

https://doi.org/10.1590/1807-1929/agriambi.v29n1e283055

Synthesis, Antileishmanial Activity, and in silico Study of 2-Hydroxy 3 (1,2,3 triazolyl)propyl Vanillin Derivatives Synthesis Activity 2Hydroxy Hydroxy 2 1,2,3 123 1 (1,2, triazolylpropyl triazolyl propyl 1,2, 12 (1,2 1,2 (1, 1, (1 (
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Santiago, Samira S.

; Freitas, Camila S.

; Costa, Adilson V.

; Oliveira, Mariana B. de

; Faria, Aidene F. C.

; Belarmino, William S.

; Moura, Gisely F.

; Santos, Nayara A. dos

; Romão, Wanderson

; Lacerda Júnior, Valdemar

; Oliveira, Fabrício M. de

; Oliveira, Osmair V.

; Coelho, Eduardo A. F.

; Teixeira, Róbson R.

Journal of the Brazilian Chemical Society

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2025, Volume 36 N. 5 elocation e-20240200

Abstract: En | Text: En | PDF: En

This study details the preparation, antileishmanial assay, and in silico analysis of twenty 2-hydroxy-3-(1,2,3-triazolyl)propyl vanillin derivatives. These compounds were synthesized in three steps and evaluated against Leishmania infantum, Leishmania amazonensis, and Leishmania braziliensis promastigotes. Compounds 3s and 3t were the most effective, showing good activity against all Leishmania species tested. Molecular docking indicated that all compounds bind favorably to the sterol 14α-demethylase (CYP51) enzyme from L. infantum. ADMET (absorption, distribution, metabolism, excretion and toxicity) analysis indicated good oral bioavailability, non blood-brain barrier penetration, and high gastrointestinal absorption. Posaconazole and compounds 3e, 3s, and 3t remained stable in the CYP51 binding region during 100 ns molecular dynamics (MD) simulations. Root mean square deviation (RMSD) and root mean square fluctuations (RMSF) analyses from the MD trajectory revealed significant conformational fluctuations of the CYP51 N-terminal, suggesting occasional expulsion of 3e, potentially explaining its higher IC50 (half-maximal inhibitory concentration) values. Pairwise decomposition analyses from molecular mechanics Poisson-Boltzmann surface area (MM/PBSA) calculations highlighted the importance of hydrophobic residues in interacting with the synthesized derivatives. preparation assay 2hydroxy31,2,3triazolylpropyl 2hydroxy3123triazolylpropyl hydroxytriazolylpropyl 2 hydroxy 3 1,2,3 triazolyl propyl 1 derivatives infantum amazonensis promastigotes s t effective tested 14αdemethylase αdemethylase 14α demethylase α CYP (CYP51 L absorption, absorption (absorption distribution metabolism toxicity bioavailability bloodbrain blood brain penetration 3e e CYP5 10 (MD simulations RMSD (RMSD RMSF (RMSF Nterminal, Nterminal N terminal, terminal N-terminal IC IC5 halfmaximal half maximal concentration values PoissonBoltzmann Poisson Boltzmann MM/PBSA MMPBSA MM PBSA (MM/PBSA 2hydroxy31 3triazolylpropyl triazolylpropyl 123 1,2, (CYP5 2hydroxy3 12 1,2 (CYP 2hydroxy 1,

https://doi.org/10.21577/0103-5053.20240200

Fertigation with copper in beet crop in a semi-arid region semiarid semi arid
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Costa, Romualdo M. C.

; Grangeiro, Leilson C.

; Lima, Renner B. de

; Pereira, Natali A. E.

; Costa, João P. N. da

; Alves, Anderson A.

; Bezerra, Larisa R. F. C.

; Lacerda, Rodolfo R. de A.

; Sá, Francisco V. da S.

; Fernandes, Bruno C. C.

; Chagas, Paulo S. F. das

Revista Brasileira de Engenharia Agrícola e Ambiental

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mar 2024, Volume 28 N. 3 elocation e276908

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O cobre é um elemento essencial à beterraba, no entanto, é necessário disponibilizá-lo em quantidade adequada uma vez que esse nutriente, que é um metal pesado, pode causar toxicidade às plantas e, ou, ao ser humano. Esta pesquisa teve como objetivo avaliar o desempenho agronômico de beterraba fertirrigada com cobre em uma região semiárida do Brasil. Foram conduzidos dois experimentos em delineados em blocos casualizados ao acaso, com cinco tratamentos (0, 1.5, 3.0, 4.5 e 6.0 kg ha-1 de cobre) e quatro repetições. Em 2019, o teor de cobre estava dentro da faixa adequada para a beterraba. Em 2021, a fertirrigação com cobre acima de 0.8 kg ha-1 proporcionou teores na faixa de fitotoxicidade, o que pode explicar a redução no acúmulo de massa seca total e de raízes tuberosas. A adubação com cobre aumentou a produtividade comercial em 2019 (17.32 t ha-1 na dose de 3.9 kg ha-1 de cobre) enquanto que, em 2021, não houve modelo ajustado. A adubação alterou o pH da raiz tuberosa, mas não influenciou nos demais atributos de qualidade pós-colheita da raiz tuberosa. Plantas adubadas com cobre acumularam mais cobre nas folhas do que na raiz tuberosa, com máxima acumulada em 2019 e em 2021, na dose 6.0 kg ha-1 de cobre. A adubação com 3.9 kg ha-1 é adequada para solos com baixo teor de cobre. entanto disponibilizálo disponibilizá lo nutriente pesado ou humano Brasil acaso 0, 0 (0 15 1 5 1.5 30 3 3.0 45 4 4. 60 6 6. ha1 ha ha- repetições 2021 08 8 0. fitotoxicidade tuberosas 201 17.32 1732 17 32 (17.3 39 9 3. ajustado tuberosa póscolheita pós colheita ( 1. 202 20 17.3 173 (17. 2 17. (17 (1

ABSTRACT Copper is an essential element for beet; however, it needs to be made available in adequate quantities since this nutrient, which is a heavy metal, can cause toxicity to plants and/or humans. This study aimed to evaluate the agronomic performance of beet fertigated with copper in a semi-arid region of Brazil. Two experiments were carried out in complete randomized blocks, with five treatments (0, 1.5, 3.0, 4.0, and 6.0 kg ha-1 of copper) and four replicates. In 2019, the copper content was within the adequate range for beet. In 2021, fertigation with copper above 0.8 kg ha-1 led to contents in the phytotoxicity range, which may explain the reduction in total and tuberous root dry mass accumulation. Fertilization with copper increased marketable yield in 2019 (17.32 t ha-1 at the dose of 3.9 kg ha-1 of copper), while, in 2021, there was no fit of the equations. Copper fertilization altered the tuberous root pH but did not influence the other tuberous root quality components. Plants fertilized with copper accumulated more copper in the leaves than in the tuberous root, with a maximum accumulation of 6.0 kg ha-1 of copper in 2019 and 2021. Fertilization with 3.9 kg ha-1 suits soils with low copper content. however nutrient metal andor or humans semiarid semi arid Brazil blocks 0, 0 (0 15 1 5 1.5 30 3 3.0 40 4 4.0 60 6 6. ha1 ha ha- replicates 2021 08 8 0. 201 17.32 1732 17 32 (17.3 39 9 3. copper, , while equations components ( 1. 4. 202 20 17.3 173 (17. 2 17. (17 (1

https://doi.org/10.1590/1807-1929/agriambi.v28n3e276908

Quality of life of women from a quilombola community in northeastern Brazil
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Santos, E. N. A.

; Magalhães, P. K. A.

; Santos, A. M.

; Correia, M. S.

; Santos, J. C. S.

; Carvalho Neto, A. P. M.

; Souza, M. A.

; Lima, R. F.

; Fonseca, S. A.

; Ferreira-Júnior, G. C.

; Cavalcanti, M. G. S.

; Costa, J. G.

; Matos-Rocha, T. J.

Brazilian Journal of Biology

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2024, Volume 84 elocation e246463

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo As comunidades quilombolas, estão presentes em diversos estados brasileiros, vivendo em condições de saúde mais precárias. Isto ocorre por conta do isolamento geográfico, das limitações de acesso e da falta de qualidade no serviço quando este é prestado. Nesse sentido, o objetivo do estudo foi analisar a qualidade de vida de mulheres de uma comunidade quilombola do nordeste brasileiro. Estudo observacional, transversal e descritivo. Foram entrevistadas 160 mulheres adultas, através de um formulário para a coleta de perfil e do questionário de Qualidade de Vida WHOQOL – bref. Foi observado que as mulheres tinham em média 40,7 anos (±17,25), casadas, autodeclaradas negras, com fundamental incompleto, do lar, sem renda, com moradia de alvenaria, própria, com até 6 cômodos, abastecidas por caixa de água comunitária, tratada. A Qualidade de Vida, apresentou escores medianos nos domínios: físico (3,18), psicológico (3,4), relações sociais (3,45) e meio ambiente (2,59). Com a realização desta pesquisa foi possível caracterizar a comunidade quilombola de Santa Luzia do Norte-AL quanto as dificuldades de acesso a saúde e geração de renda, fatos que repercutem na sua condição de saúde. Os problemas descritos neste estudo podem contribuir para que ações de saúde sejam planejadas e efetivadas com o intuito de melhorar as condições socioeconômicas e de saúde nessa comunidade, considerando-se o contexto social, político e ambiental, valorizando seus saberes e práticas tradicionais.

Abstract Quilombola communities are present in many Brazilian states living in precarious health conditions. This is due to geographic isolation, limitations to the access of the area in which they live in, and the lack of quality in the service when it is needed to be provided. Therefore, the aim of this study was to analyze the quality of life of women from a quilombola community in northeastern Brazil. It is an observational, cross-sectional and descriptive study. 160 adult women were first interviewed through a form to collect a profile and then it was applied the WHOQOL Quality of Life questionnaire – bref. It was observed that the women were on average 40.7 years old (±17.25), married, self-declared black, who did not finish elementary school, housewife, had no income, with their own masonry house, with up to 6 rooms, supplied by a box of community treated water. Quality of Life had median scores in the domains: physical (3.18), psychological (3.4), social relationships (3.45) and environment (2.59). With this research, it was possible to characterize the quilombola community of Santa Luzia do Norte-AL regarding the difficulties of access to health and income generation, issues that affect their health condition. The problems described in this study can contribute to health actions being planned and carried out in order to improve socioeconomic and health conditions in this community, considering the social, political and environmental context, valuing their traditional knowledge and practices.

https://doi.org/10.1590/1519-6984.246463

Physiological responses of tambaqui (Colossoma macropomum) fed diets supplemented with silage from fish and vegetables residues
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Costa, M. N. F.

; Furtado, Y. I. C.

; Monteiro, C. C.

; Brasiliense, A. R. P.

; Yoshioka, E. T. O

Brazilian Journal of Biology

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2024, Volume 84 elocation e255493

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A procura por insumos que substituam produtos de alto custo, como óleo e farinha de peixe, na fabricação de rações para uso na aquicultura é crescente, sendo necessário garantir a qualidade nutricional das dietas. A silagem produzida a partir de resíduos de pescado e de vegetais apresenta-se como uma alternativa de baixo custo e eficiente fonte proteica. O objetivo do presente estudo foi avaliar as respostas fisiológicas e bioquímicas de alevinos de tambaqui alimentados com quatro níveis de inclusão de silagem em ração comercial com 28% de proteína bruta, em dois períodos: 45 e 90 dias. Cada tratamento foi realizado em três repetições, com 10 tambaquis em cada caixa experimental de 100 L. Ao término de cada período estabelecido, amostras sanguíneas foram coletadas de cinco animais de cada repetição para determinação das variáveis hematológicas e bioquímicas. Peso, comprimento total e índices hepatossomático e lipossomático de espécimes alimentados com silagem não mostraram alterações significativas em ambos os períodos de avaliação, bem como os valores de hematócrito. A concentração de hemoglobina de tambaqui após 45 dias de alimentação aumentou quando foi fornecida dieta com inclusão de 20% de silagem. A contagem de eritrócitos, volume corpuscular médio e hemoglobina corpuscular média não apresentaram alterações entre os tratamentos, em ambos os períodos. As proteínas totais aumentaram significativamente no plasma de tambaquis que receberam dietas com inclusão de 5 e 10% de silagem, avaliados após 45 dias de alimentação. Evidenciou-se que os grupos com inclusão de silagem na dieta não apresentaram alterações significativas nos parâmetros avaliados, assim não sendo prejudiciais à higidez do tambaqui. Portanto, o uso da silagem como suplemento alimentar durante o cultivo do tambaqui é uma alternativa sustentável para produtores, por promover a redução do descarte de resíduos de pescado e da agricultura.

Abstract The demand for products to replace high-cost raw materials, such oil and fish meal, in the manufacture of feed for use in aquaculture, while also guaranteeing the nutritional quality of the diets, is increasing. Silage produced with fish and vegetables residues is a low-cost and efficient protein source. The objective of the present study was to evaluate the physiological and biochemical responses of tambaqui fingerlings fed four different levels of silage included in commercial feed with 28% crude protein, over two periods: 45 and 90 days. Each treatment was carried out over three replications, with 10 tambaqui in each 100 L experimental tank. At the end of each established period, blood samples were collected from five animals from each repetition to determine the hematological and biochemical variables. Body weight and total length, hepatosomatic and liposomal indices and hematocrit of specimens fed with diets supplemented with silage did not exhibit significant changes in both assessment period. After 45 days of feeding, the hemoglobin concentration increased when tambaqui were fed a diet including 20% silage. The red blood cell count, mean corpuscular volume and mean corpuscular hemoglobin did not change between treatments in either period. The total protein concentrations increased significantly in the plasma of tambaqui fed with diets with the inclusion of 5 and 10% of silage, evaluated after feeding for 45 days. It was found that the groups which had silage included in their diet did not exhibit significant alterations in the evaluated parameters, and the diet was therefore not consider harmful to the health of tambaqui. Therefore, the use of silage as a feed supplement during tambaqui farming is a sustainable alternative for producers, as it leads to a reduction of impacts of fish and vegetables waste disposal.

https://doi.org/10.1590/1519-6984.255493

Dopamine depletion in wistar rats with epilepsy
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Trindade-Filho, E. M.

; Pai, J. Dal

; Castro, D. N. de

; Silva, A. T. M. da

; Costa, A. F.

; Vieira, J. S. S.

; Santos, S. D. B. dos

; Félix, V. B.

; Leão, S. A. B. F.

; Zambrano, L. I.

; Saldanha-Filho, A. J. M.

; Carvalho, E. G. A.

; Cavalcante, J. B. N.

; Quintella, G. B.

; Lino, A. T. S.

; Costa, M. V.

; Lima, J. A.

; Tavares, M. M. A.

; de Melo, M. R.

; Mousinho, K. C.

; Biase, C. L. C. L. De

; Leite, M. L.

; Costa, P. J. M. S.

; Becker, E. L.

; Moura, I. M. F. B.

; Silva, J. C. da

Brazilian Journal of Biology

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2024, Volume 84 elocation e248411

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O conteúdo de dopamina nas estruturas cerebrais tem sido relacionado à excitabilidade neuronal e várias abordagens têm sido utilizadas para estudar este fenômeno durante o período de vulnerabilidade às crises. No presente trabalho, descrevemos os efeitos da depleção de dopamina após a administração de 6-hidroxidopamina (6-OHDA) na região pars compacta da substância negra de ratos submetidos ao modelo de epilepsia com pilocarpina. A susceptibilidade ao estado de mal epiléptico induzido pela pilocarpina, bem como a frequência de crises espontâneas e recorrentes durante o período crônico do modelo foi determinada. Sendo o hipocampo uma das principais estruturas afetadas no desenvolvimento desse modelo experimental de epilepsia, os níveis de dopamina nessa região foram determinados após a administração da droga. No primeiro experimento, 62% (15/24) dos ratos pré-tratados com 6-OHDA e 45% (11/24) daqueles que receberam ácido ascórbico como solução controle evoluíram para crises límbicas motoras e para o estado de mal epiléptico, após a administração de pilocarpina. A gravidade das crises durante o período agudo do modelo foi significativamente maior nos ratos epilépticos experimentais (56,52%) do que nos ratos controle (4,16%). No segundo experimento, não houve diferença significante entre os grupos quanto à frequência de crises na fase crônica do modelo. Nossos dados mostraram que a dopamina pode desempenhar um papel importante na gravidade das crises na fase aguda da pilo, o que parece ser exercido por sua ação inibitória da dopamina sobre a expressão motora das crises.

Abstract The dopamine content in cerebral structures has been related to neuronal excitability and several approaches have been used to study this phenomenon during seizure vulnerability period. In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. Susceptibility to pilocarpine-induced status epilepticus (SE), as well as spontaneous and recurrent seizures (SRSs) frequency during the chronic period of the model were determined. Since the hippocampus is one of main structures in the development of this experimental model of epilepsy, the dopamine levels in this region were also determined after drug administration. In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. Severeness of seizures during the model´s the acute period, was significantly higher in epileptic experimental rats (56.52%), than in controls (4.16%). In the second experiment, the frequency of seizures in the model’s chronic phase did not significantly change between groups. Our data show that dopamine may play an important role on seizure severity in the pilo’s model acute period, which seems to be due to dopamine inhibitory action on motor expression of seizure.

https://doi.org/10.1590/1519-6984.248411

Spatio-temporal analysis of the visceral leishmaniasis in the state of Alagoas, Brazil
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Ferreira, J. R. S.

; Silva, K. M.

; Cavalcanti, M. G. S.

; Ferreira-Júnior, G. C.

; Souza, E. C.

; Magalhães, P. K. A.

; Gomes, D. C. S.

; Fonseca, S. A.

; Maranhão, T. L. G. Q.

; Rocha, M. A. N.

; Nascimento, C. M. A.

; Lima, R. F.

; Alves, L. C.

; Brayner, F. A.

; Costa, J. G. da

; Matos-Rocha, T. J.

Brazilian Journal of Biology

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2024, Volume 84 elocation e253098

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A leishmaniose visceral é uma doença tropical negligenciada. Foram avaliadas a distribuição espacial dos casos de leishmaniose visceral no estado de Alagoas. Todos os casos de LV, registrados pela secretaria de saúde, foram analisados e georreferenciados. Entre 2008 e 2017, 97,1% dos municípios apresentaram classificação esporádica de transmissão. Com a evolução temporal, a incidência de casos de leishmaniose visceral se concentrou na maioria dos municípios da microrregião de Santana do Ipanema-AL. A análise espaço-tempo, se considerada, pode promover o aprimoramento das ações de vigilância e controle da leishmaniose visceral.

Abstract Visceral leishmaniosis is a neglected tropical disease. We evaluated the spatial distribution of cases of visceral leishmaniosis in the state of Alagoas, Brazil. All cases of VL, registered by the health department, were analyzed and georeferenced. Results: Between 2008 and 2017, 97.1% of the municipalities presented sporadic classification of transmission. With temporal evolution, the incidence of cases of visceral leishmaniosis was concentrated in most municipalities in the microregion of Santana do Ipanema-AL. Space-time analysis, if considered, may promote the improvement of surveillance and control actions of visceral leishmaniosis.

https://doi.org/10.1590/1519-6984.253098

Annotation of Alkaloids of Fusaea longifolia and Evaluation of Anti-Plasmodium Activity in vitro and in silico AntiPlasmodium Anti Plasmodium
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Adrião, Asenate A. X.

; Silva, Carlos V. A. da

; Araujo, Morgana S.

; Paz, Weider H. P.

; Medeiros, Lívia S. de

; Silva, Felipe M. A. da

; Bezerra, Daniel P

; Salimo, Zeca M.

; Monteiro, Wuelton M.

; Melo, Gisely C. de

; Costa, Emmanoel V.

; Tavares, Josean F.

; Koolen, Hector H. F.

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 7 elocation e-20240016

Abstract: En | Text: En | PDF: En

Isoquinoline alkaloids, especially from the Annonaceae family, have shown biological potential against parasites. Thus, this study aimed to evaluate the potential of the alkaloid fractions of the plant Fusaea longifolia against Plasmodium falciparum and annotate the compounds present in these samples. The tentative characterization of the alkaloids from the leaves and branches of F. longifolia was performed using liquid chromatography coupled to mass spectrometry (LC-MS/MS) and molecular networks. Through manual interpretation of the MS/MS spectra, 18 alkaloids were dereplicated from F. longifolia, 17 of which were reported for the first time in this species. An unpublished putative glycosylated alkaloid was annotated by interpreting the fragmentation data profile. Regarding biological activity, the fractions studied showed high activity against P. falciparum with half-maximal inhibitory concentration (IC50) of 2.42 and 1.60 μg mL-1 for branches and from the leaves, respectively, both similar to the reference standard quinine (IC50 of 1.24 μg mL-1). The structures of the 17 alkaloids were subjected to in silico analysis using molecular docking against four enzymes related to anti-Plasmodium activity (wild type (dm-PfDHFR) and mutant type (qm-PfDHFR), dihydroorotate dehydrogenase (PfDHODH) and purine nucleoside phosphorylase (PfPNP)). Molecular docking revealed strong interactions, especially between oxoxylopine 17 and hydroxycassythicine N-oxide 10, which may be potential new sources against P. falciparum. family parasites Thus samples F LCMS/MS LCMSMS LC MS (LC-MS/MS networks MSMS spectra 1 species profile P halfmaximal half maximal IC50 IC 242 2 42 2.4 160 60 1.6 mL1 mL mL- respectively (IC5 124 24 1.2 mL1. . mL-1) antiPlasmodium anti wild dmPfDHFR dm PfDHFR (dm-PfDHFR qmPfDHFR, qmPfDHFR qm , (qm-PfDHFR) PfDHODH (PfDHODH PfPNP. PfPNP (PfPNP)) interactions Noxide N oxide 10 LCMS IC5 4 2. 16 6 1. (IC 12 (qm-PfDHFR (PfPNP) (PfPNP

https://doi.org/10.21577/0103-5053.20240016

10.

PdAg/CoFe2O4 Bimetallic Catalyst with High Selectivity for Glyceraldehyde in Glycerol Selective Oxidation Reaction PdAgCoFe2O4 PdAgCoFeO PdAg CoFe2O4 CoFe O PdAg/CoFe2O PdAgCoFe PdAgCoFe2O CoFeO CoFe2O
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Falcão, Milton S.

; Moura, Edmilson M. de

; Costa, Jean C. S.

; Melo, Antonio F. A. A.

; Paz, Gilvan M.

; Nascimento, Ronaldo F. do

; Nascimento, Hélio O. do

; Montoro, Luciano A.

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 7 elocation e-20240007

Abstract: En | Text: En | PDF: En

The catalytic oxidation of glycerol was investigated in assays with palladium-silver bimetallic nanoparticles (Pd-Ag) immobilized on cobalt ferrite (CoFe2O4). Bimetallic nanoparticles were prepared by the galvanic replacement method, immobilized on CoFe2O4 by wet impregnation. Bimetallic Pd-Ag nanoparticles with 35 wt.% Pd content effectively catalyzed the selective oxidation reaction of glycerol to glyceraldehyde. Catalytic oxidation was carried out at 60-80 °C for 2-4 h in an aqueous NaOH solution (NaOH:glycerol ratio = 4 mol:mol) under O2 pressure of 4 bar; the selectivity of glyceraldehyde reached 99.35% and the conversion of glycerol of 49.07% at a temperature of 60 °C and a reaction time of 2 h. Glyceric acid and traces of tartronic acid and mesoxalic acid were also detected. The catalyst was also very stable, showing activity up to 4 runs without significant loss of activity and selectivity. palladiumsilver palladium silver PdAg Ag (Pd-Ag CoFe2O4. CoFeO . CoFe O (CoFe2O4) method CoFe2O impregnation 3 wt wt. 6080 80 60-8 C 24 2- NaOHglycerol molmol mol mol:mol bar 9935 99 99.35 4907 49 07 49.07 6 detected stable (CoFe2O4 608 8 60- 993 9 99.3 490 0 49.0 (CoFe2O 99. 49.

https://doi.org/10.21577/0103-5053.20240007

11.

Ocimum gratissimum essential oil in the transport water of Brycon hilarii: implications at water quality, blood parameters and residues in tissue and plasma hilarii quality
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Oliveira, F. C.

; Moreira, A. P.

; Ferreira, A. L.

; Costa, D. C.

; Cardoso, C. A. L.

; Chaves, F. C. M.

; Chagas, E. C.

; Campos, C. M.

Brazilian Journal of Biology

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2024, Volume 84 elocation e280240

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O transporte de peixes vivos é uma prática comum na piscicultura, e é certamente um dos principais problemas que afetam a homeostase dos peixes e neste cenário o uso de aditivos naturais tem-se mostrado promissor para melhorar a resistência dos peixes frente a situações adversas. Este estudo teve como objetivo avaliar o impacto do óleo essencial de Ocimum gratissimum L. (OEOG) na qualidade de água, perfil hematológico e níveis de resíduos no plasma, filé e fígado de juvenis de piraputanga (Brycon hilarii) durante um período de transporte de duas horas. Os peixes foram divididos em sacos plásticos (4 L) e expostos a três concentrações diferentes de OE OG (10, 20 e 30 mg L-1) enquanto um grupo não recebeu OEOG. Cada grupo com três repetições. Após o transporte de duas horas, foram coletadas amostras de sangue, bem como de filé e do fígado para a quantificação dos compostos do óleo essencial, que também foram mensurados no plasma. Os níveis de oxigênio permaneceram elevados durante todo o período do transporte, em todos os grupos, enquanto o pH diminuiu. A hemoglobina, CHCM e HCM aumentaram nos peixes dos grupos EOOG 20 e 30 mg L-1, em comparação ao grupo controle. No entanto, a contagem dos linfócitos e as concentrações decompostos no plasma, filé e fígado aumentaram com a concentração mais elevada de OEOG. O uso de 10 mg L-1 de OGEO na água de transporte de duas horas é promissor para garantir a sobrevivência e o bem-estar dos juvenis de Brycon hilarii (pesando 16 g), mostrando-se seguro e eficaz. A concentração residual de eugenol, composto majoritário do OGEO no filé, permanece abaixo do limite máximo da ingestão diária recomendada. piscicultura temse tem se adversas L OEOG (OEOG plasma 4 ( 10, (10 2 3 L1 1 repetições sangue diminuiu hemoglobina L1, 1, controle entanto L- bemestar estar pesando g, g , g) mostrandose mostrando eficaz eugenol recomendada (1

Abstract Transporting live fish is a common practice in fish farming, and is certainly one of the main problems that affect fish homeostasis. In this scenario, the use of natural additives has shown promise in improving fish resistance to adverse situations. This study aimed to assess the impact of Ocimum gratissimum L. essential oil (OGEO) on water quality, hematological parameters, and residue levels in the plasma, fillet, and liver of juvenile piraputanga (Brycon hilarii) during a two-hour transportation period. The fish were divided into plastic bags (4 L) and exposed to three different OGEO concentrations (10, 20, and 30 mg L-1), while a control group received no OGEO (three repetitions each). After the two-hour transportation, blood samples were collected, as well as portions of the fillet and liver for quantifying essential oil compounds, which were also measured in the plasma. Oxygen levels remained high throughout the transportation period, in all groups, while the pH decreased. Hemoglobin, MCHC, and MCH increased in fish exposed to OGEO concentrations of 20 and 30 mg L-1, compared to the control group. However, lymphocyte counts and the concentrations of essential oil compounds in plasma, fillet, and liver increased with higher OGEO concentrations. The use of 10 mg L-1 OGEO in the two-hour transport water is promising to ensure the survival and well-being of Brycon hilarii juveniles (weighing 16 g), showing to be safe and effective. The residual concentration of eugenol the major compound of OGEO in the fillet remains below the maximum limit of the recommended daily intake. farming homeostasis scenario situations L (OGEO quality parameters plasma twohour two hour period 4 ( 10, (10 3 L1, L1 1 , L-1) each. each . each) collected groups decreased Hemoglobin MCHC 2 1, However L- wellbeing being weighing g, g g) effective intake (1

https://doi.org/10.1590/1519-6984.280240

12.

Power Series Solution for Korteweg-De Vries Equation KortewegDe Korteweg De
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COSTA, F. S.

; SOARES, J. C. A.

; ARAUJO, G. L.

; SOUSA, M. V. S.

Trends in Computational and Applied Mathematics

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2024, Volume 25 elocation e01502

Abstract: En | Text: En | PDF: En

ABSTRACT We apply the similarity method to the Korteweg-de Vries equation, where we obtain a new equation, in terms of similarity variable. We use the power series method, getting the similarity solution, which is exemplified graphically by particular cases. Kortewegde Korteweg de equation variable solution cases

https://doi.org/10.5540/tcam.2024.025.e01502

13.

The high biodiversity of benthic organisms in a coastal ecosystem revealed by an integrative approach
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Amaral, A. Cecília Z.

; Cunha, Beatriz P.

; Checon, Helio H.

; Godoy, Angélica S. de

; Silva, Camila F. da

; Corte, Guilherme N.

; Nogueira, João M. de M.

; Fukuda, Marcelo V.

; Steiner, Tatiana M.

; Kawauchi, Gisele Y.

; Turra, Alexander

; Denadai, Márcia R.

; Ferreira, Luciane

; Mendonça, Joel B. de

; Tavares, Marcos

; Leite, Fosca P. P.

; Costa, Mariana F. B.

; Siqueira, Silvana G. L.

; Vieira, Leandro M.

; Dias, Gustavo M.

; Teixeira, Joyce A.

; Rocha, Rosana M.

; Gusmão, Luciana C.

; Borges, Michela

; Alitto, Renata

; Machado, Fabrizio M.

; Passos, Flávio D.

; Cunha, Carlo M.

; Simone, Luiz R.L.

; Araujo, Ana Paula G.

; Carbayo, Fernando

; Bahia, Juliana

; Bulnes, Verónica N.

; Castello-Branco, Cristiana

; Hajdu, Eduardo

; Vilas-Boas, Ana Carolina

; Garraffoni, André R. S.

; Schockaert, Ernest

; Fonseca, Gustavo

; Domenico, Maikon Di

; Curini-Galletti, Marco

; Sørensen, Martin V.

; Hochberg, Rick

; Oliveira, Ana Julia F. C. de

; Zampieri, Bruna Del B.

; Chinelatto, Roberta M.

; Migotto, Alvaro E.

Biota Neotropica

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2024, Volume 24 N. 2 elocation e20231583

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O aumento da modificação dos habitats e da perda de espécies demanda esforços consistentes para descrever e compreender os padrões de biodiversidade. O programa BIOTA/FAPESP foi criado nesse contexto e é uma iniciativa de sucesso para promover estudos em biodiversidade e conservação no Brasil. O BIOTA/Araçá é um projeto interdisciplinar que promoveu uma avaliação detalhada da biodiversidade da Baía do Araçá, um ecossistema costeiro localizado ao Norte do estado de São Paulo, Sudeste do Brasil. A baía engloba múltiplos habitats, tais como praias, manguezais, costões rochosos, e uma planície de maré, e também fornece importantes serviços ecossistêmicos. Infelizmente, a baía está sujeita à conflitos sócio-ambientais complexos que contrastam demandas econômicas, sociais e ambientais (i.e. a expansão das atividades do porto vizinho vs. a pesca artesanal de pequena escala e a proteção da biodiversidade). O presente estudo apresenta um levantamento das espécies bentônicas que ocorrem nos diferentes habitats da Baía do Araçá, incluindo dados obtidos durante o projeto BIOTA/Araçá e de investigações realizadas anteriormente na área. As espécies bentônicas desempenham um papel importante no ambiente marinho, e estudar a diversidade desses organismos que vivem associados ao fundo é indispensável para compreender o funcionamento do meio ambiente. A macrofauna, meiofauna, e microorganismos associados aos fundos consolidado e inconsolidado foram listados, e informações adicionais foram fornecidas para cada espécie, tais como a distribuição geográfica e nos habitats. O checklist inclui 826 espécies, quase 70% registradas durante o projeto BIOTA/Araçá. Os taxa mais especiosos foram os anelídeos (225 spp.), moluscos (194 spp.), e crustáceos (177 spp.). Entre as espécies bentônicas listadas, sete são endêmicas da Baía do Araçá, 14 são consideradas ameaçadas de extinção, e sete são exploradas economicamente. A baía é a localidade tipo de vários taxa, e 11 novas espécies bentônicas foram descritas com base em espécimes amostrados durante o projeto. Este projeto mostra a importância da Baía do Araçá como um ambiente de riqueza biológica única e demonstra a necessidade de esforços para a sua conservação considerando as atuais ameaças. BIOTAFAPESP BIOTA FAPESP Brasil BIOTAAraçá Paulo praias manguezais rochosos maré ecossistêmicos Infelizmente sócioambientais sócio econômicas i.e. ie i (i.e vs . biodiversidade) área marinho macrofauna meiofauna listados espécie 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. listadas 1 extinção economicamente ameaças i.e 8 7 22 (2 19 (1 17 2 (

Abstract Increasing habitat modification and species loss demand consistent efforts to describe and understand biodiversity patterns. The BIOTA/FAPESP Program was created in this context and it has been a successful initiative to promote studies on biodiversity and conservation in Brazil. The BIOTA/Araçá is an interdisciplinary project that provided a detailed evaluation of the biodiversity of Araçá Bay, a coastal seascape located on the North coast of the state of São Paulo, Southeast Brazil. The bay encompasses multiple habitats, such as beaches, mangroves, rocky shores, and a tidal flat, and provides important ecosystem services. Unfortunately, the bay is the subject of complex social-environmental conflicts that oppose economic, social, and environmental demands (i.e., the expansion of neighboring harbor activities vs. small-scale artisanal fisheries and protection of biodiversity). The present study presents a survey of the benthic species occurring in the different habitats of Araçá Bay, including data obtained during the BIOTA/Araçá project and previous assessments of the area. The benthic species play an important role in marine environments and studying the diversity of these organisms that live associated with the bottom is indispensable for comprehending the environment’s functioning. The macrofauna, meiofauna, and microorganisms associated with soft and hard bottom were listed, and additional information, such as the habitat and geographical distribution, were provided for each species. The checklist includes 826 species, almost 70% recorded during the BIOTA/Araçá project. The most speciose taxa were the annelids (225 spp.), mollusks (194 spp.), and crustaceans (177 spp.). Seven benthic species are endemic to Araçá Bay, 14 are considered threatened, and seven are economically exploited. Furthermore, the bay is the type locality of many taxa, and 11 new benthic species were described based on specimens sampled during the project. This project shows the importance of Araçá Bay as a unique biologically rich environment and highlights the need for conservation efforts in light of the current threats. patterns BIOTAFAPESP BIOTA FAPESP Brazil BIOTAAraçá Paulo beaches mangroves shores flat services Unfortunately socialenvironmental social economic i.e., ie i e (i.e. vs smallscale small scale biodiversity. . biodiversity) area s functioning macrofauna meiofauna listed information distribution 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. 1 threatened exploited Furthermore threats i.e. (i.e 8 7 22 (2 19 (1 17 i.e 2 (

https://doi.org/10.1590/1676-0611-bn-2023-1583

14.

Coleoptera of Brazil: what we knew then and what we know now. Insights from the Catálogo Taxonômico da Fauna do Brasil Brazil now
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Caron, Edilson

; Monné, Marcela L.

; Ferreira, Vinicius S.

; Costa, Cleide

; Cupello, Mario

; Aloquio, Sergio

; Linzmeier, Adelita M.

; Vaz-de-Mello, Fernando Z.

; Leivas, Fernando W.T.

; Souza-Gonçalves, Igor

; Mermudes, José R.M.

; Almeida, Lúcia M.

; Moura, Luciano de A.

; Ferreira Júnior, Nelson

; Grossi, Paschoal C.

; Vanin, Sergio A.

; Ślipiński, Adam

; Anichtchenko, Alexander

; Newton, Alfred F.

; Sampaio, Aline

; Carelli, Allan

; Puker, Anderson

; Ferreira, André da S.

; Fernandes, André S.

; Roza, André S.

; Cline, Andrew

; Sampaio, Brunno H.L.

; Clarkson, Bruno

; Castro, Camila F. de

; Bicho, Carla de L.

; Benetti, César J.

; Ribeiro-Costa, Cibele S.

; Lopes-Andrade, Cristiano

; Manfio, Daiara

; Colpani, Daniara

; Basílio, Daniel S.

; Bená, Daniela de C.

; Pollock, Darren A.

; Souza, Diego de S.

; Rodrigues, Diego F.

; Chandler, Donald S.

; Nascimento, Elynton A. do

; Spiessberger, Erich L.

; Agrain, Federico A.

; Barbosa, Felipe F.

; Shockley, Floyd

; Nascimento, Francisco E. de L.

; Biffi, Gabriel

; Powell, Gareth S.

; Morse, Geoffrey E.

; Flores, Gustavo E.

; Escalona, Hermes

; Quintino, Hingrid Y.S.

; Rainho, Hugo L.

; Maddalena, Italo S.C.P.

; Hájek, Jiří

; McHugh, Joseph V.

; Botero, Juan P.

; Fuhrmann, Juares

; Churata-Salcedo, Julissa M.

; Vieira, Letícia M.

; Silveira, Luiz F.L. da

; Cruz, Luiza S. da

; Sekerka, Lukás

; Bologna, Marco A.

; Bevilaqua, Marcus V.O.

; Passos, Maria I.

; Chamorro, Maria L.

; Cherman, Mariana A.

; Bento, Matheus

; Gimmel, Matthew

; Segura, Melissa O.

; Ivie, Michael A.

; Thomas, Michael C.

; Monné, Miguel A.

; Lord, Nathan

; Hamada, Neusa

; Degallier, Nicolas

; Santos, Paula B. dos

; Duarte, Paulo R.M.

; Gnaspini, Pedro

; Bulirsch, Petr

; Regalin, Renato

; Leschen, Richard A.B.

; Constantin, Robert

; Corrêa, Rodrigo C.

; Gerstmeier, Roland

; Rosa, Simone P.

; Campos, Stéphanie V.N.

; Peck, Stewart B.

; Pacheco, Thaynara L.

; Polizei, Thiago T.S.

; McElrath, Thomas C.

; Grzymala, Traci L.

; Smith, Trevor R.

; Costa-Silva, Vinicius da

; Sandoval-Gómez, Vivian E.

; Sousa, Wesley O. de

; Tomaszewska, Wioletta

Zoologia (Curitiba)

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2024, Volume 41 elocation e23072

Abstract: En | Text: En | PDF: En

ABSTRACT In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, including representatives of all extant suborders and superfamilies. Our data show that the Brazilian beetle fauna is the richest on the planet, concentrating 9% of the world species diversity, with some estimates accounting to up to 15% of the global total. The most diverse family in numbers of genera is Cerambycidae (1,056 genera), while in number of species it is Chrysomelidae (6,079 species). Conotrachelus Dejean, 1835 (Curculionidae) is the most species-rich genus, with 570 species. The French entomologist Maurice Pic is the author who has contributed the most to the naming of species recorded from Brazil, with 1,794 valid names in 36 families, whereas the Brazilians Ubirajara R. Martins and Maria Helena M. Galileo are the only ones among the top-ten authors to have named species in the 21st century. Currently, approximately 144 new species of Brazilian beetles are described each year, and this average is projected to increase in the next decade to 180 species per year, or about one new Brazilian beetle every two days. 2000 ra Twentyfour Twenty four later CTFB Brasil 10 globe Costas s Brazil 35699 35 699 35,69 4958 4 958 4,95 11 country superfamilies planet 9 diversity 15 total 1,056 1056 1 056 (1,05 genera, , genera) 6,079 6079 6 079 (6,07 . species) Dejean 183 Curculionidae (Curculionidae speciesrich rich genus 57 1794 794 1,79 3 R M topten top ten st century Currently 14 year 18 days 200 3569 69 35,6 495 95 4,9 1,05 105 05 (1,0 6,07 607 07 (6,0 5 179 79 1,7 20 356 35, 49 4, 1,0 0 (1, 6,0 60 (6, 17 7 1, 2 (1 6, (6 (

https://doi.org/10.1590/s1984-4689.v41.e23072

15.

Bioactive potential of Eugenia luschnathiana essential oil and extract: antifungal activity against Candida species isolated from oncological patients extract
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Costa, P. C. Q. G. da

; Nogueira, P. L.

; Nascimento, Y. M. do

; Sobral, M. V.

; Silvestre, G. F. G.

; Castro, R. D. de

Brazilian Journal of Biology

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2024, Volume 84 elocation e286419

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Indivíduos imunossuprimidos, a exemplo dos que fazem tratamento para o câncer, são mais suscetíveis a infecções fúngicas, como a candidíase oral, que podem afetar diretamente sua qualidade de vida e, consequentemente, seu processo de recuperação. Diante das limitações relacionadas às atuais opções terapêuticas, a descoberta de novos agentes antifúngicos, incluindo os de origem natural, é fundamental para o correto manejo dessas infecções. Este estudo investigou o perfil fitoquímico, a atividade antifúngica do óleo essencial e extrato etanólico bruto (EEB) obtidos de Eugenia luschnathiana sobre cepas referência e isoladas clínicas de Candida de pacientes sob tratamento oncológico e realizou a caracterização toxicológica. Para análise fitoquímica foram usados cromatografia gasosa acoplada ao espectrofotômetro de massas (CG-EM) e Ressonância Magnética Nuclear (RMN) de 1H. A avaliação antifúngica foi conduzida para determinação da Concentração Inibitória Mínima (CIM) e da Concentração Fungicida Mínima (CFM); avaliação dos potenciais mecanismos de ação; avaliação da atividade sobre biofilme fúngico; determinação da letalidade para larvas de Artemia salina. A CG-EM identificou predominância de sesquiterpenos no óleo essencial, sendo (E)-Caryophyllene o composto majoritário. O espectro de RMN de 1H identificou compostos alifáticos, osídos e aromáticos no extrato etanólico bruto. O OE não apresentou atividade antifúngica. O EEB mostrou atividade fungicida, com CIM e CFM variando de 1,95 µg/mL a 3,90 µg/mL para cepas testadas, estes valores permaneceram inalterados na presença de ergosterol exógeno, com possível mecanismos de ação sobre estruturas que envolvem parede celular fúngica. Em baixa concentração (19.5 µg/mL), o EEB inibiu 62.78% do biofilme de Candida albicans. A CL50 do EEB para A. salina foi de 142,4 µg/mL. Observa-se, então, que o EEB possui atividade antifúngica muito forte, com ação provável sobre parede celular, efeito sobre biofilme e perfil de toxicidade compatível para realização de outras investigações. imunossuprimidos câncer fúngicas oral consequentemente recuperação terapêuticas antifúngicos natural fitoquímico (EEB toxicológica CGEM CG EM (CG-EM (RMN H (CIM (CFM) fúngico ECaryophyllene E Caryophyllene majoritário alifáticos fungicida 195 1 95 1,9 µgmL µg mL 390 3 90 3,9 testadas exógeno fúngica 19.5 19 5 (19. µg/mL, , µg/mL) 6278 62 78 62.78 albicans CL CL5 1424 142 4 142, Observase, Observase Observa se, se Observa-se então forte investigações (CFM 9 1, 39 3, 19. (19 627 6 7 62.7 14 (1 62. (

Abstract Immunosuppressed individuals, including those undergoing cancer treatment, are more vulnerable to fungal infections, such as oral candidiasis, impacting their quality of life. Given the limitations of current therapies, the discovery of new antifungal agents, including those of natural origin, is crucial for the proper managing of these infections. We investigated the phytochemical profile and antifungal activity of both the essential oil and crude ethanolic extract (CEE) obtained from Eugenia luschnathiana against reference strains and clinical isolates of Candida from oncology patients. Toxicological characterization was also conducted. Gas chromatography coupled to mass spectrometry (GC-MS) and 1H Nuclear Magnetic Resonance (NMR) were used for phytochemical analysis. Antifungal evaluation was conducted to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC); evaluation of potential mechanisms of action; activity on a fungal biofilm; evaluation of the cytotoxic effect on human keratinocytes of the HaCat lineage by the MTT method; determination of lethality for Artemia salina larvae. GC-MS identified a predominance of sesquiterpenes in the essential oil, notably (E)-Caryophyllene. The 1H NMR spectrum identified aliphatic, osidic, and aromatic compounds in the crude ethanolic extract. The essential oil showed no antifungal activity. However, the CEE exhibited fungicidal activity, with MIC and MFC ranging from 1.95 µg/mL to 3.90 µg/mL. The antifungal effect was affected by sorbitol, indicating a possible mechanism targeting fungal cell wall structures. At low concentration (19.5 µg/mL), the CEE inhibited 62,78% of C. albicans biofilm. The CEE demonstrated a promising toxicity profile, with an LC50 of 142.4 µg/mL against Artemia salina. In conclusion, the CEE from Eugenia luschnathiana exhibited potent antifungal activity, likely through cell wall disruption, biofilm inhibition, and a favorable toxicity profile for further exploration. individuals treatment infections candidiasis life therapies agents origin (CEE patients GCMS GC MS (GC-MS H (NMR analysis (MIC (MFC) action method larvae ECaryophyllene. ECaryophyllene E Caryophyllene. Caryophyllene (E)-Caryophyllene aliphatic osidic However 195 1 95 1.9 µgmL µg mL 390 3 90 3.9 sorbitol structures 19.5 19 5 (19. µg/mL, , µg/mL) 6278 62 78 62,78 C LC LC5 1424 142 4 142. conclusion disruption inhibition exploration (MFC 9 1. 39 3. 19. (19 627 6 7 62,7 14 (1 62, (

https://doi.org/10.1590/1519-6984.286419

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