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Resumo O objetivo deste trabalho foi avaliar o efeito do óleo essencial de Eucalyptus staigeriana sobre o crescimento micelial e a germinação de conídios de Colletotrichum gloeosporioides e Greeneria uvicola em uvas, assim como o seu potencial para o controle de podridões no período pós-colheita e o seu efeito nas propriedades organolépticas das uvas. O óleo essencial (OE) apresentou atividade antifúngica in vitro contra ambos os patógenos, com efeito fungicida sobre o crescimento micelial e sobre a germinação de conídios, nas concentrações de 1,0 e 0,5 μL mL−1, respectivamente. Os compostos voláteis do OE exibiram efeito fungistático sobre o crescimento micelial de C. gloeosporioides e efeito fungicida sobre G. uvicola. Na pós-colheita, o OE reduziu a incidência da podridão-madura em até 75 e 86%, nos tratamentos preventivos e curativos, respectivamente, e a incidência da podridão-amarga em até 54% no tratamento curativo. Como o OE não influencia significativamente as propriedades sensoriais das uvas, não afeta a intenção de consumo para uvas tratadas com o OE. O OE de E. staigeriana é eficiente para o controle in vitro de ambos os patógenos; além disso, também é eficiente no controle da incidência de podridões fúngicas no período pós-colheita, principalmente no tratamento curativo.

Abstract The objective of this work was evaluate the effect of Eucalyptus staigeriana essential oil on Colletotrichum gloeosporioides and Greeneria uvicola mycelial growth and conidia germination on grapes, as well as its potential for the control of postharvest rot diseases and its effect on the organoleptic properties of grapes. The essential oil (EO) showed in vitro antifungal activity against both pathogens, with fungicidal effect on mycelial growth and on conidia germination at the concentrations of 1.0 and 0.5 μL mL−1, respectively. The EO volatile compounds had a fungistatic effect on the mycelial growth of C. gloeosporioides and a fungicidal effect on G uvicola. At postharvest, the EO reduced the incidence of ripe rot up to 75% and 86% in the preventive and curative treatments, respectively, and the incidence of bitter rot up to 54% in the curative treatment. Since the EO does not affect significantly grape sensory properties, it does not affect the consumption intention of grapes treated with the EO. The EO of E. staigeriana is efficient in the in vitro control of both pathogens; moreover, it is also efficient in the control of the incidence of postharvest fungal rot diseases, mainly in the curative treatment.

https://doi.org/10.1590/s1678-3921.pab2022.v57.02782

Carcinoma de recto metastásico a piel asociado a síndrome de Treacher Collins. Reporte de un caso
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Rojas-Rivera, Alfonso

; Ordoñez-Thevening, Christian H.

; Ríos-Corso, Coralia G.

; Vázquez-Gómez, Guadalupe K.

Gaceta mexicana de oncología

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2021, Volume 20 Suppl. 1 Pages 41 - 44

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract We report the case of a 23-year-old patient assessed in the Radiotherapy Service of the General Hospital of Mexico with a diagnosis of Treacher Collins and seal ring cell adenocarcinoma of the rectum, presenting cutaneous metastases compatible with seal ring cell adenocarcinoma; she is candidate for external radiotherapy. This syndrome occurs in 1 per 50,000 live births and it is rare that it presents with rectal cancer and skin metastasis, here the importance of presenting this case, with the unknown if it is related to oncologic pathology of the patient.

Resumen Se reporta el caso de una paciente de 23 años valorada en el Servicio de Radioterapia del Hospital General de México con diagnóstico de Treacher Collins y adenocarcinoma de recto en células en anillo de sello T4bN1M1. Presenta metástasis cutáneas compatibles con adenocarcinoma de células en anillo de sello, candidata a radioterapia externa. Este síndrome se presenta en 1 por 50,000 nacidos vivos y es poco frecuente que se presente con cáncer de recto y metástasis a piel, de aquí la importancia de presentar este caso, con la incógnita de si está relacionado con la patología oncológica de la paciente.

https://doi.org/10.24875/j.gamo.20000103 22 downloads

Time of nitrogen supply in yield, industrial and chemical quality of oat grains
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Kraisig, Adriana R.

; Silva, José A. G. da

; Carvalho, Ivan R.

; Mamann, Ângela T. W. De

; Corso, Janiele S.

; Norbert, Leonardo

Revista Brasileira de Engenharia Agrícola e Ambiental

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oct 2020, Volume 24 N. 10 Pages 700 - 706

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O momento de aplicação de nitrogênio em aveia pode melhorar a eficiência de aproveitamento do nutriente e a expressão da produtividade e qualidade de grãos. O objetivo do estudo foi indicar a melhor época de aplicação de nitrogênio em aveia, considerando diferentes condições de fornecimento de doses de nitrogênio na semeadura e em cobertura na produtividade e nos indicadores da qualidade industrial e química de grãos, considerando dois sistemas de sucessão de cultivo do cereal no Brasil. O experimento foi conduzido no ano de 2018, em Augusto Pestana, RS, Brasil. O delineamento foi o de blocos casualizados com quatro repetições, em esquema fatorial 3 × 4, para três doses de nitrogênio na semeadura (0, 30 e 60 kg ha-1) alterando a dose em cobertura pelo total fornecido de 70 e 100 kg ha-1 em sistema soja/aveia e milho/aveia, respectivamente. O fornecimento do nutriente em cobertura foi em quatro épocas (0, 10, 30 e 60 dias) após a emergência da aveia. A ausência do nutriente na semeadura e aplicação da dose total em cobertura ao redor de 30 dias após emergência proporciona resultados vantajosos, melhorando a produtividade e indicadores da qualidade industrial e química dos grãos.

ABSTRACT The timing of nitrogen application in oats can improve the efficiency of use of the nutrient and the expression of productivity and quality of grains. The objective of the study was to indicate the best time of application of nitrogen in oats, considering different conditions of nitrogen dose in the sowing/topdressing in the expression of productivity and the effects on the indicators of industrial and chemical quality of grains, considering the main succession systems of cereal cultivation in Brazil. The experiment was conducted in 2018, in Augusto Pestana, RS, Brazil. The design was randomized blocks with four repetitions, in a 3 × 4 factorial scheme, with three doses of nitrogen at sowing (0, 30 and 60 kg ha-1), changing the topdressing dose by the total supply of 70 and 100 kg ha-1 in succession system soybean/oats and corn/oats, respectively, with the timings of supply in topdressing at 0, 10, 30 and 60 days after emergence. The total doses were defined looking for grain yield expectations of 4000 kg ha-1. In the management of nitrogen in oats, the absence of the nutrient at sowing and application of the total dose in topdressing around 30 days after emergence provides advantageous results, improving productivity and indicators of industrial and chemical quality of grains.

https://doi.org/10.1590/1807-1929/agriambi.v24n10p700-706 470 downloads

Nitrogen management in the relationships between oat inflorescence components and productivity
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Mantai, Rubia D.

; Silva, José A. G. da

; Binelo, Manuel O.

; Sausen, Airam T. Z. R.

; Rossi, Dênis S.

; Corso, Janiele S.

Revista Brasileira de Engenharia Agrícola e Ambiental

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2020, Volume 24 N. 6 Pages 385 - 393

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Existem entre os componentes da inflorescência da aveia diferentes magnitudes de contribuição de expressão da produtividade de grãos e industrial pelo estímulo do nitrogênio; deste modo, propôs-se dimensionar e interpretar a contribuição e a dinâmica de relações dos componentes da inflorescência da aveia com a produtividade de grãos e industrial pelo estímulo do fertilizante nitrogenado, particionando os valores de correlação em efeitos diretos e indiretos por diagnóstico de trilha, fortalecido pela análise conjunta de distintos anos agrícolas. O estudo foi conduzido de 2011 a 2016, no município de Augusto Pestana, RS, em delineamento experimental de blocos casualizados com quatro repetições em esquema fatorial 4 x 2 para doses de nitrogênio (0, 30, 60 e 120 kg ha-1) e cultivares de aveia (Barbarasul e Brisasul) em sistema soja/aveia e milho/aveia. No sistema soja/aveia, a massa e o número de espiguetas da panícula e a massa de grãos da panícula, detém maior contribuição em promover alterações pelo incremento do nitrogênio. No sistema milho/aveia, as variáveis com maior contribuição são, a massa e o número de espiguetas da panícula. O acréscimo da massa de grãos da panícula e do índice de colheita da panícula incrementam a produtividade de grãos, porém, juntamente com o número de grãos da panícula, reduzem a produtividade industrial, independente do sistema de cultivo.

ABSTRACT Among oat inflorescence components there are different magnitudes of contribution to expression of grain and industrial productivity by nitrogen stimulation. Thus, it was proposed to size and interpret the contribution and dynamics of the relationships of oat inflorescence components with grain and industrial yield by N-fertilizer stimulation, partitioning correlation values into direct and indirect effects by path diagnosis, strengthened by the joint analysis of different agricultural years. The study was carried out from 2011 to 2016, in the municipality of Augusto Pestana, RS, Brazil, in a randomized block design with four repetitions in a 4 x 2 factorial scheme for nitrogen doses (0, 30, 60 and 120 kg ha-1), using oat cultivars (Barbarasul and Brisasul) in soybean/oat and corn/oat systems. In the soybean/oat system, the mass and the number of panicle spikelets and the mass of panicle grains, contributed more to promoting changes by the increase of nitrogen. In the corn/oat system, the variables with the highest contribution are the mass and the number of panicle spikelets. The increase in panicle grain mass and in panicle harvest index increases grain yield, however, together with the number of panicle grains, they reduce industrial productivity, regardless of the cultivation system.

https://doi.org/10.1590/1807-1929/agriambi.v24n6p385-393 2226 downloads

Resistencia antimicrobiana y epidemiología molecular de aislamientos de Staphylococcus pseudintermedius de muestras clínicas de caninos
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Vigo, Germán B.

; Giacoboni, Gabriela I.

; Gagetti, Paula S.

; Pasterán, Fernando G.

; Corso, Alejandra C.

Revista argentina de microbiología

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sep 2015, Volume 47 N. 3 Pages 206 - 211

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Twenty-eight strains isolated from dog clinical samples identified as Staphylococcus pseudintermedius by mass spectrometry (MALDI-TOF) were studied to assess antimicrobial susceptibility by the diffusion method and clonal relationship by pulsed field gel electrophoresis (PFGE). Methicillin resistance (3/28 isolates; 10,7 %) was evaluated by mecA PCR. Fifteen strains (53.6 %) were resistant to at least one of the antibiotics tested, and eleven of them (39.3 %) showed multiple resistance (3 or more antimicrobial families). Eleven isolates (39.3 %) were resistant to erythromycin due to the presence of ribosomal methylase ermB, whereas clindamycin inducible resistance was not detected. Twenty-seven (27) clonal types were differentiated by PFGE, suggesting high clonal diversity. We emphasize that the finding of multiresistant S. psedintermedius strains is an emerging problem to be considered in veterinary diagnostic laboratory treatment of canine infections and in public health settings.

Se estudiaron 28 aislamientos obtenidos de muestras clínicas de perros e identificados por espectrometría de masas (MALDI-TOF) como Staphylococcus pseudintermedius; el objetivo fue evaluar la sensibilidad a los antimicrobianos por el método de difusión y establecer la relación clonal entre aislamientos por electroforesis en campo pulsado (PFGE). La resistencia a meticilina se evaluó mediante PCR por amplificación del gen mecA y se observó en 3/28 aislamientos (10,7 %). Quince aislamientos (53,6 %) presentaron resistencia a alguno de los antibióticos ensayados y 11 de ellos (39,3 %) presentaron resistencia múltiple (resistencia a 3 o más familias de antibióticos). Once aislamientos (39,3 %) presentaron resistencia a eritromicina, debido a la presencia de metilasa ribosomal ermB, y no se detectó resistencia inducible a clindamicina. Por PFGE se pudieron diferenciar 27 tipos clonales, lo cual demuestra gran diversidad clonal. Se destaca el hallazgo de aislamientos de S. pseudintermedius multirresistentes como una eventual problemática a considerar en el diagnóstico veterinario de laboratorio, el tratamiento de las infecciones caninas y el ámbito de la salud pública.

https://doi.org/10.1016/j.ram.2015.06.002 1010 downloads

A scale-free network of evoked words
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Ferreira, A. A. A.

; Corso, G.

; Piuvezam, G.

; Alves, M. S. C. F.

Brazilian Journal of Physics

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sep 2006, Volume 36 N. 3a Pages 755 - 758

Abstract: En | Text: En | PDF: En

We use a set of evoked words to define the vertices of a network. The connections between vertices are established by individuals in a population that evoke these words. The resulting graph is called an Evoked Words Network, EWN. The data of evoked words comes from an epidemiological research in odontological public health. In this research we consider three concept themes or evocative words: mouth, disease, and health. We investigate these words in two populations: an upper middle class and a poor district of the city of Natal. We compare and analyze six EWNs. The distribution of connectivities of all of these EWNs indicates a scale-free structure, with the data fitting a power law. The analyzed quantities of the EWNs depend more on the concept theme than on the income of population. This conclusion is discussed in the context of language-based networks.

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Infecciones invasivas por Streptococcus pneumoniae: estudio epidemiológico e importancia del desarrollo de un sistema de vigilancia
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Ruvinsky, Raúl

; Gentile, Angela

; Regueira, Mabel

; Corso, Alejandra

; Ruvinsky, Raúl

; Gentile, Angela

; Regueira, Mabel

; Corso, Alejandra

; Pace, Julio

; Bakir, Julia

; Di Fabio, José Luis

; Rossi, Alicia

; Altschuler, Marta

; González Ayala, Silvia

; Hernández, Claudia

; Rubeglio, Etelvina

; Bologna, Rosa

; Grenón, Sara

; Von Specht, Marta

; Mayoral, Claudia

; Beltramino, Juan Carlos

; Carabajal, Laura

; Silverberg, Raquel

; Rial, María José

; Alarcón, Nora

; Ferrero, Fernando

; Yudowski, Susana

; Tregnaghi, Miguel

; Balbi de Aguirre, Laura

; Aprá, Ernestina Q.

; Vázquez, Mabel

; Galanternic, Laura

; Procopio, Adriana

; Logarzo, Daniel

; Meccia, Aída L.

; Kremer, Clara

; Perez, Carlota

; Cuza, Nélida

; Villagra de Trejo, Ana

; Lura de Calafell, María Cristina

; Pierini de Gaite, Judith

; Fabre, Rosa

; Dalamón, Ricardo

; Bruno, Miriam

; Díaz, Nora

; Noriega, Marta

; Gómez, Diana

Revista de la Sociedad Boliviana de Pediatría

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jun 2004, Volume 43 N. 2 Pages 107 - 115

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Las infecciones invasivas por Streptococcus pneumoniae (Spn) producen mortalidad elevada en países en desarrollo, con tasas entre 4 y 100 veces mayores que las de Estados Unidos o Canadá. Es el primer agente causal de neumonía en la infancia y de meningitis fuera de los brotes epidémicos por Neisseria meningitidis. La OPS, a través del grupo SIREVA, dedicado al desarrollo de vacunas en Latinoamérica, organizó un programa de vigilancia de infecciones invasivas por Spn en seis países: Argentina, Brasil, Chile, Colombia, México y Uruguay, iniciado en 1993 y que continúa actualmente. En Argentina participan en la actualidad más de 20 centros hospitalarios distribuidos en todas las áreas geográficas del país, actuando como Centro Nacional de referencia para la serotipificación y determinación de la resistencia a los antibióticos el Instituto ANLIS "Dr. Carlos G. Malbrán". Objetivos: 1) Determinar los serotipos predominantes, su resistencia a los antibióticos y los cambios temporales en infecciones invasivas por Spn de niños menores de 5 años de edad. 2) Obtener información confiable para la formulación de una vacuna conjugada adecuada para la región. Metodología: diseño prospectivo observacional. Se incluyeron todos los niños menores de 6 años de edad internados por infecciones invasivas (neumonía, meningitis, sepsis o bacteriemia), en los que se aisló Spn de un sitio previamente estéril. Se realizó control externo de confiabilidad de los resultados, inicialmente en el laboratorio de referencia de Canadá y actualmente en el Instituto Adolfo Lutz de San Pablo. El análisis estadístico se realizó con EPIINFO 6 y con el programa WHONET de OMS. Resultados: se destacan los siguientes hallazgos: Se aisló Spn en 1.390 muestras clínicas. La edad media (N= 1.175) fue de 19,5 meses, con 74,4% - 2 años; fueron neumonías 60,5%; meningitis 26,6%, sepsis 8,2%. Se halló sensibilidad disminuida a penicilina en 32,1% (414/1.288), con resistencia alta 16,1% e intermedia 16%. La resistencia a los antibióticos betalactámicos se incrementó en el período 1993-8. Los serotipos prevalentes fueron: 14 (32,5%), 6A/ 6B, 9V, 23F, 19F, 18C, 4, 5, 1. Los serotipos 14 y 6AB prevalecieron en menores de 2 años mientras que el 5 y el 1 prevalecieron en mayores de 2 años (p <0,001). El serotipo 14, la neumonía y la edad menor de 2 años fueron los factores de riesgo para resistencia a penicilina. La representatividad para las vacunas conjugadas 7-valente, 9-valente y 11-valente fue de 53,3%, 77,4% y 82,6% respectivamente, mayor para la 7-valente en los menores de 2 años (61,2%) y en los menores de 2 años con neumonía (71,2%). Más del 90% de los serotipos aislados con algún grado de resistencia estuvieron contenidos en las tres vacunas analizadas. Conclusiones: un programa nacional de vigilancia de Spn invasivo fue desarrollado en Argentina y otros países latinoamericanos. Se identificaron por primera vez los serotipos predominantes en infecciones invasivas y se comprobó el incremento significativo de la resistencia a penicilina y otros antibióticos, similar a lo informado en casi todos los países del mundo. Se obtuvo información epidemiológica válida para evaluar estrategias de prevención con nuevas vacunas.

Since 1993, the PAHO, through the Regional Vaccine System (SIREVA Group) organized a surveillance protocol of invasive Streptococcus pneumoniae (Spn) infections in children less than 5 years old in six Latin-American countries: Argentina, Brazil, Chile, Colombia, Mexico and Uruguay. In Argentina more than 20 hospitals are now participating in this project. Objectives: 1) to determine the predominant serotypes, the antibiotic resistance and changes along the time. 2) To know the representativity of the serotypes isolated in the new conjugated vaccines. Methodology: children less than 6 years old hospitalized by Spn invasive infections were included (pneumonia, meningitis, bacteremia o sepsis). The ANLISS "Dr. Carlos G. Malbrán" Institute was the reference center for Spn serotyping and antibiotic resistance determination. Results: Spn was isolated from 1.390 clinical samples. The average age was 19.5 months, 74.4% belonged to children equal or less than 2 years of age. The main clinical diagnosis were: pneumonia 60.5%, meningitits 26.6%, fever without foccus (bacteremia) or sepsis 8.2%. Decreased penicillin sensitivity (DPS) was found in 32.1% of the cases, with high resistance in 16.1% and intermediate resistance in 16%; the increase of DPS in the 1993- 98 period was significant, like in other countries. The more frequent serotypes were: 14 (32.5%), 6A/6B, 9V, 23F, 19F, 18C, 4, 5, and 1. Serotypes 14 and 6AB were prevalent in children less than 2 years old and serotypes 5 and 1, in children than 2 years older (p <0.001). Serotype 14, pneumonia and age less than 2 years were risk factors for penicillin resistance. Finally, the representativity of the serotypes in the new conjugated vaccines 7- valent, 9-valent and 11-valent was: 53.3%, 77.4% and 82.6% respectively. For the 7-valent vaccine, was higher in the less than 2 years old group (61.2%), and for this age group with pneumonia (71.2%). More than 90% of penicillin resistant serotypes were included in the three conjugated vaccines. Conclusions: a national surveillance program was developped in Argentina and other Latin-American countries. Prevalent invasive Spn serotypes were identified; a significative increase in penicillin and other antibiotic resistance was found, like in almost all countries. This epidemiologic information is of great importance for evaluating the new conjugated vaccines.

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Infecciones invasivas por Streptococcus pneumoniae: Estudio epidemiológico e importancia del desarrollo de un sistema de vigilancia
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Ruvinsky, Raúl

; Gentile, Ángela

; Regueira, Mabel

; Corso, Alejandra

; Ruvinsky, Raúl

; Gentile, Angela

; Regueira, Mabel

; Corso, Alejandra

; Pace, Julio

; Bakir, Julia

; Di Fabio, José Luis

; Rossi, Alicia

; Altschuler, Marta

; González Ayala, Silvia

; Hernández, Claudia

; Rubeglio, Etelvina

; Bologna, Rosa

; Grenón, Sara

; Von Specht, Marta

; Mayoral, Claudia

; Beltramino, Juan Carlos

; Carabajal, Laura

; Silverberg, Raquel

; Rial, María José

; Alarcón, Nora

; Ferrero, Fernando

; Yudowski, Susana

; Tregnaghi, Miguel

; Balbi de Aguirre, Laura

; Q. Aprá, Ernestina

; Vázquez, Mabel

; Galanternic, Laura

; Procopio, Adriana

; Logarzo, Daniel

; Meccia, Aída L

; Kremer, Clara

; Pérez, Carlota

; Cuza, Nélida

; Villagra de Trejo, Ana

; Lura de Calafell, María Cristina

; Pierini de Gaite, Judith

; Fabre, Rosa

; Dalamón, Ricardo

; Bruno, Miriam

; Díaz, Nora

; Noriega, Marta

; Gómez, Diana

Revista chilena de pediatría

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jan 2004, Volume 75 N. 1 Pages 77 - 79

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Since 1993, the PAHO, through the Regional Vaccine System (SIREVA Group) organized a surveillance protocol of invasive Streptococcus pneumoniae (Spn) infections in children less than 5 years old in six Latin-American countries: Argentina, Brazil, Chile, Colombia, Mexico and Uruguay. In Argentina more than 20 hospitals are now participating in this project. Objectives: 1) To determine the predominant serotypes, the antibiotic resistance and changes along the time. 2) To know the representativity of the serotypes isolated in the new conjugated vaccines. Methodology: Children less than 6 years old hospitalized by Spn invasive infections were included (pneumonia, meningitis, bacteremia o sepsis). The ANLISS "Dr. Carlos G. Malbrán" Institute was the reference center for Spn serotyping and antibiotic resistance determination. Results: Spn was isolated from 1 390 clinical samples. The average age was 19.5 months, 74.4% belonged to children equal or less than 2 years of age. The main clinical diagnosis were: pneumonia 60.5%, meningitits 26.6%, fever without foccus (bacteremia) or sepsis 8.2%. Decreased penicillin sensitivity (DPS) was found in 32.1% of the cases, with high resistance in 16.1% and intermediate resistance in 16%; the increase of DPS in the 1993-98 period was significant, like in other countries. The more frequent serotypes were: 14 (32.5%), 6A/6B, 9V, 23F, 19F, 18C, 4, 5, and 1. Serotypes 14 and 6AB were prevalent in children less than 2 years old and serotypes 5 and 1, in children than 2 years older (p < 0.001). Serotype 14, pneumonia and age less than 2 years were risk factors for penicillin resistance. Finally, the representativity of the serotypes in the new conjugated vaccines 7-valent, 9-valent and 11-valent was: 53.3%, 77.4% and 82.6% respectively. For the 7-valent vaccine, was higher in the less than 2 years old group (61.2%), and for this age group with pneumonia (71.2%). More than 90% of penicillin resistant serotypes were included in the three conjugated vaccines. Conclusions: A national surveillance program was developped in Argentina and other Latin-American countries. Prevalent invasive Spn serotypes were identified; a significative increase in penicillin and other antibiotic resistance was found, like in almost all countries. This epidemiologic information is of great importance for evaluating the new conjugated vaccines

Las infecciones invasivas por Streptococcus pneumoniae (Spn) producen mortalidad elevada en países en desarrollo, con tasas entre 4 y 100 veces mayores que las de Estados Unidos o Canadá. Es el primer agente causal de neumonía en la infancia y de meningitis fuera de los brotes epidémicos por Neisseria meningitidis. La OPS, a través del grupo SIREVA, dedicado al desarrollo de vacunas en Latinoamérica, organizó un programa de vigilancia de infecciones invasivas por Spn en seis países: Argentina, Brasil, Chile, Colombia, México y Uruguay, iniciado en 1993 y que continúa actualmente. En Argentina participan en la actualidad más de 20 centros hospitalarios distribuidos en todas las áreas geográficas del país, actuando como Centro Nacional de referencia para la serotipificación y determinación de la resistencia a los antibióticos el Instituto ANLIS "Dr. Carlos G. Malbrán". Objetivos: 1) Determinar los serotipos predominantes, su resistencia a los antibióticos y los cambios temporales en infecciones invasivas por Spn de niños menores de 5 años de edad; 2) Obtener información confiable para la formulación de una vacuna conjugada adecuada para la región. Metodología: Diseño prospectivo observacional. Se incluyeron todos los niños menores de 6 años de edad internados por infecciones invasivas (neumonía, meningitis, sepsis o bacteriemia), en los que se aisló Spn de un sitio previamente estéril. Se realizó control externo de confiabilidad de los resultados, inicialmente en el laboratorio de referencia de Canadá y actualmente en el Instituto Adolfo Lutz de San Pablo. El análisis estadístico se realizó con EPIINFO 6 y con el programa WHONET de OMS. Resultados: Se destacan los siguientes hallazgos: Se aisló Spn en 1 390 muestras clínicas. La edad media (N = 1 175) fue de 19,5 meses, con 74,4% - 2 años; fueron neumonías 60,5%; meningitis 26,6%, sepsis 8,2%. Se halló sensibilidad disminuida a penicilina en 32,1% (414/1 288), con resistencia alta 16,1% e intermedia 16%. La resistencia a los antibióticos betalactámicos se incrementó en el período 1993-8. Los serotipos prevalentes fueron: 14 (32,5%), 6A/6B, 9V, 23F, 19F, 18C, 4, 5, 1. Los serotipos 14 y 6AB prevalecieron en menores de 2 años mientras que el 5 y el 1 prevalecieron en mayores de 2 años (p < 0,001). El serotipo 14, la neumonía y la edad menor de 2 años fueron los factores de riesgo para resistencia a penicilina. La representatividad para las vacunas conjugadas 7-valente, 9-valente y 11-valente fue de 53,3%, 77,4% y 82,6% respectivamente, mayor para la 7-valente en los menores de 2 años (61,2%) y en los menores de 2 años con neumonía (71,2%). Más del 90% de los serotipos aislados con algún grado de resistencia estuvieron contenidos en las tres vacunas analizadas. Conclusiones: Un programa nacional de vigilancia de Spn invasivo fue desarrollado en Argentina y otros países latinoamericanos. Se identificaron por primera vez los serotipos predominantes en infecciones invasivas y se comprobó el incremento significativo de la resistencia a penicilina y otros antibióticos, similar a lo informado en casi todos los países del mundo. Se obtuvo información epidemiológica válida para evaluar estrategias de prevención con nuevas vacunas

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Anisotropy and percolation threshold in a multifractal support
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Lucena, L. S.

; Freitas, J. E.

; Corso, G.

; Soares, R. F.

Brazilian Journal of Physics

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sep 2003, Volume 33 N. 3 Pages 637 - 640

Abstract: En | Text: En | PDF: En

Recently a multifractal object, Qmf, was proposed to allow the study of percolation properties in a multifractal support. The area and the number of neighbors of the blocks of Qmf show a non-trivial behavior. The value of the probability of occupation at the percolation threshold, p c, is a function of r, a parameter of Qmf which is related to its anisotropy. We investigate the relation between p c and the average number of neighbors of the blocks as well as the anisotropy of Qmf.

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10.

Visualizando os Modos Normais de Vibração com o Computador
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Jácome, S. S. B.

; Medeiros, F. F. de

; Corso, G.

; Lucena, L. S.

Revista Brasileira de Ensino de Física

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jun 2002, Volume 24 N. 2 Pages 214 - 220

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Neste trabalho desenvolvemos um programa educativo versando sobre modos normais em uma cadeia de osciladores acoplados. O usuário do programa pode simular a evolução dinâmica de uma cadeia de osciladores escolhendo condições iniciais tanto em coordenadas cartesianas como em coordenadas normais. Focalizamos o efeito do desacoplamento do sistema de equações diferenciais (passagem de coordenadas cartesianas para coordenadas normais) sobre as trajetórias dos osciladores do ponto de vista da dinâmica qualitativa. Através das características da evolução dinâmica, quase-periodicidade ou periodicidade, o estudante ganha intuição sobre o significado das formas normais.

In this work we develop an educational software about normal modes in a chain of coupled oscillators. The software simulates the dynamical evolution of the system allowing to choose initial conditions in cartesian coordinates or in normal modes. We focus on the effect of decoupling the system of differential equations (transition from cartesian coordinates to normal modes) in the qualitative dynamics of the oscillators, either in the quasiperiodic or in the periodic regime. The purpose is to give the student some insights about the meaning of the normal modes.

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