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Abstract Objective To report the prevalence of malignant transformation of vulvar lichen sclerosus (VLS) and possible risk factors. Methods This is a cohort study with data analysis from medical records of 138 patients with histological diagnosis of VLS registered at the Vulvar Pathology Outpatient Clinic of the University Hospital, between 2007 and 2017. Predominance of risk factors was performed using logistic regression analysis. The variables studied were the length of follow-up, age, regular or irregular follow up; presence of symptoms (dyspareunia, pruritus and/or vulvar burning); histology characteristics, the presence of epithelial hyperplasia; and the presence of autoimmune diseases. Results There were 138 patients included in the study, and among them five progressed to malignant transformation. The patients had a median age of 59 years and 83% were symptomatic. The most frequent symptom was itching with 72%. Autoimmune diseases were present in 11.6%, the most prevalent being thyroid disease. All five case of malignant transformation (0.6%) had an irregular follow up. The logistic regression analysis was used among the studied variables, and no statistical significance was found among them (p ≥ 0.05). The relationship between hyperplasia and the clinical outcome of malignant transformation, in which non-significant but acceptable p value close to 0.05 was observed. Conclusion The prevalence of malignant transformation in patients with VLS was 0.6%, and common factors were the lack of adherence to medical treatments and the loss of follow-up. (VLS 13 Hospital 200 2017 followup, followup up, up follow-up dyspareunia, dyspareunia (dyspareunia andor burning burning) characteristics 5 83 symptomatic 72 72% 116 11 6 11.6% disease 0.6% 06 0 (0.6% 0.05. 005 . 05 0.05) nonsignificant non significant 0.0 observed followup. 1 20 201 8 7 11.6 0.6 (0.6 00 0. 2 11. (0. (0 (

https://doi.org/10.61622/rbgo/2024rbgo62

Handgrip strength in Parkinson’s disease: A systematic review of observational studies Parkinsons Parkinson s disease
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Mazza, Rodrigo Oliveira

; Silva, Ana Elisa Lemos

; Machado, Lucas Telles

; Britto, Vera Lúcia Santos de

; Paz, Thiago da Silva Rocha

; Correa, Clynton Lourenço

Fisioterapia em Movimento

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2024, Volume 37 elocation e37203

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução Pessoas com doença de Parkinson (DP) podem apresentar fraqueza muscular. O teste de força de preensão é usado para identificar a força de membros superiores. Exis-tem diferentes descrições de protocolos para esta avaliação. Objetivo Realizar uma revisão sistemática na avaliação da força de preensão em pessoas com DP. Métodos A revisão foi realizada de acordo com as diretrizes PRISMA, nos bancos de dados eletrônicos PubMed, SciELO, LILACS e Scopus e registrada na PROSPERO (CRD42020190018). Análise quan-titativa foi realizada utilizando a escala Newcastle-Ottawa. Vinte e sete artigos foram analisados. Resultados O protocolo mais referenciado é o da Sociedade Americana de Terapeutas da Mão. O instrumento mais utilizado é o dinamômetro hidráulico. Dos dezesseis estudos que compararam a força de preensão entre pessoas com DP e sujeitos saudáveis, sete identi-ficaram diferença estatisticamente significante. Nenhum artigo foi classificado como insatisfatório. Conclusão Não é possível afirmar que a força de preensão manual está reduzida na DP quando comparada com pessoas saudáveis. Padronização de protocolo e de instrumento podem ajudar comparações entre resultados de diferentes estudos. Existem poucos estudos lon-gitudinais, o que torna difícil compreender o que ocorre com a força de preensão com a evolução da doença. (DP muscular superiores Exis tem PRISMA PubMed SciELO CRD42020190018. CRD42020190018 CRD . (CRD42020190018) quantitativa quan titativa NewcastleOttawa. NewcastleOttawa Newcastle Ottawa. Ottawa Newcastle-Ottawa analisados Mão hidráulico saudáveis identificaram identi ficaram significante insatisfatório longitudinais, longitudinais lon gitudinais, gitudinais lon-gitudinais CRD4202019001 (CRD42020190018 CRD420201900 (CRD4202019001 CRD42020190 (CRD420201900 CRD4202019 (CRD42020190 CRD420201 (CRD4202019 CRD42020 (CRD420201 CRD4202 (CRD42020 CRD420 (CRD4202 CRD42 (CRD420 CRD4 (CRD42 (CRD4 (CRD

Abstract Introduction People with Parkinson’s disease may pre-sent muscle weakness. The handgrip test is used to identify upper limbs strength. There are different protocol descriptions of this assessment. Objective To carry out a systematic review on the assessment of handgrip strength in people with Parkinson’s. Methods The review was carried out according to the PRISMA guidelines, the PubMed, SciELO, LILACS and Scopus literary databases, and registered at PROSPERO (CRD420201 9018). Quantitative analysis was performed using the Newcastle-Ottawa Scale. Twenty-seven articles were analyzed. Results The most referenced protocol is that of the American Society of Hand Therapists. The most used instrument is the hydraulic dynamometer. Of the sixteen studies that compared handgrip strength be-tween people with Parkinson’s and healthy people, seven identified a statistically significant difference. No article was classified as unsatisfactory. Conclusion It is not possible to affirm that handgrip strength is reduced in Parkinson’s disease, when compared to healthy subjects. Protocol and instrument standardization can help com-parisons between results from different studies. There are few longitudinal studies, making it difficult to under-stand what happens to handgrip strength as the disease progresses. Parkinsons Parkinson s present pre sent weakness Parkinsons. s. guidelines PubMed SciELO databases CRD420201 CRD (CRD42020 9018. 9018 . 9018) NewcastleOttawa Newcastle Ottawa Scale Twentyseven Twenty analyzed Therapists dynamometer be tween difference unsatisfactory subjects comparisons com parisons understand under stand progresses CRD42020 (CRD4202 901 CRD4202 (CRD420 90 CRD420 (CRD42 9 CRD42 (CRD4 CRD4 (CRD

https://doi.org/10.1590/fm.2024.37203

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal SISBIOTADiptera SISBIOTA Network longterm long term Amazon Cerrado
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 N. 4 elocation e20230051

Abstract: En | Text: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists. SISBIOTABRASIL SISBIOTA BRASIL threeyear year multimilliondollar multimillion dollar endangeredunderstudied endangered understudied Brazil flora processes premise Sul Rondônia forest Savannah, Savannah , Savannah) relevance surveys Therefore literature lands 9 2 researchers postdocs students technicians 300000 300 000 300,00 60 ~6 Here 4 treated 2130 130 2,13 51 altogether 29 combined respectively Overall 1 speciesrich rich Tachinidae Cecidomyiidae Tabanidae Psychodidae Sarcophagidae Stratiomyidae Bombyliidae Syrphidae Tephritidae Asilidae Mycetophilidae Muscidae Dolichopodidae Chloropidae far 11 taxonomic phylogenetic specialists 30000 30 00 300,0 6 ~ 213 13 2,1 5 3000 3 0 300, 21 2,

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Brazilians’ level of knowledge, attitudes and practices towards COVID-19: a cross-sectional study
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Gardona, Rodrigo Galvão Bueno

; da Silva, José Vitor

; Arruda, Gisele

; Damin, Silvana

; Abdala, Edson

; Lima, Christiana Almeida Salvador

; Vasconcellos, Leonardo de Souza

; Queiroz, Wladimir

; Zandonái, Alini Cristini

; Danielsk, Ailla Mazon

; Villar de Sena, Ana Carolina

; Cattani, Álvaro Cesar

; Bringhentti, Amanda

; Denardi, Angélica

; Alérico, Ana Lígia Scotti

; Fergutz, Gabriella

; Ribas, Izabela de Oliveira

; Spricigo, Laura Maria Voss

; Gandolfo, Lara

; Correa, Liamara

; Bordignon, Jardel Cristiano

; de Oliveira, Juliana Girotto

; Stefanel, Michel Pandolfo

; Reis, Beatriz Castro

; de Campos, Vilson Geraldo

; Ortigoso, Danilo

; Figueiredo, Gerusa Maria

Sao Paulo Medical Journal

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jun 2022, Volume 140 N. 3 Pages 331 - 340

Abstract: En | Text: En | PDF: En

ABSTRACT BACKGROUND: Brazil is facing increasing cycles of numbers of infected people and deaths resulting from coronavirus disease 2019 (COVID-19). This situation involves a series of factors, including the behavior of the population, that can be decisive for controlling the disease. OBJECTIVE: To determine the knowledge, attitudes and practices of the Brazilian population regarding COVID-19. DESIGN AND SETTING: Cross-sectional survey-type study, conducted using a population sample from different Brazilian states. METHODS: A quantitative, descriptive and analytical approach was used. Sampling was done according to convenience and via snowballing. The data collection instrument was a knowledge, attitudes and practices system. RESULTS: 1,655 people from all over Brazil participated in the survey; 80% were living in the southern region and 70.15% were female. More than 90% had knowledge and good attitudes relating to the means of transmission, preventive care and symptoms associated with COVID-19, although their knowledge and attitudes were not fully reflected in daily practices, for which there was lower adherence (80%). Greater knowledge was correlated with older participants, larger number of children, female sex and marital status; better attitude, with female sex and complete higher education; and better practices, with greater age, larger number of children and female sex. CONCLUSION: A large part of the population has general knowledge about COVID-19, but not all knowledge was applied in practice. Older people, females and university graduates stood out as the best informed and most committed to controlling the disease.

https://doi.org/10.1590/1516-3180.2021.0541.23072021

Analysis of dentistry content on Instagram ® and the use of social networks by Brazilian dental students
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Cumerlato, Catarina Borges da Fonseca

; Rotta, Rodrigo Nunes

; Chisini, Luiz Alexandre

; Oliveira, Luísa Jardim Corrêa de

; Correa, Marcos Britto

Brazilian Journal of Oral Sciences

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2022, Volume 21 elocation e226469

Abstract: En | Text: En | PDF: En

ABSTRACT Aim The aim of our study was to analyze the content related to dentistry published on Instagram ® and to investigate the students’ profiles related to the use of social networks in a sample from a Dentistry School. Methods This study was carried out in two stages. First, research was conducted to analyze content published on Instagram® related to dentistry. The second part investigated the profiles of students’ from a dental school in relation to the use of social networks through a questionnaire. A descriptive analysis was performed and associations between the variables were tested using Fisher’s exact test. Results We found a diversified and large amount of content related to dentistry published on Instagram ® , and publications that involved advertising were more prevalent in our study. There are also many publications that are violating the Code of Dental Ethics. In addition, in the second part of our study, we observed an enormous use of social networks by dental students (98.4%). Conclusions As a result, we believe that it is important to update professionals about the ethical infractions related to social networks which could be approached during graduate courses in universities. Finally, the analyzed social network seems to be an interesting alternative for disseminating health information in order to dialogue with greater proximity to the large number of users who participate in it.

https://doi.org/10.20396/bjos.v21i00.8666469

Particle image velocimetry technique and ultrasound method to obtain the modulus of elasticity of Bertholletia excelsa wood
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Hélio de Novais Miranda, Eduardo

; Pathele Ferreira, Rayner

; Pereira, Rodrigo Allan

; Oliveira Guedes, Taiane

; Pujaico Rivera, Fernando

; Correa Gomes, Diogo Antonio

Maderas. Ciencia y tecnología

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2022, Volume 24 elocation 13

Abstract: En | Text: En | PDF: En

Abstract: Non-destructive techniques for characterizing materials in-service have been increasing in importance. Thus, it is relevant to assess the potential of non-destructive techniques for solid materials. This work aimed to determine the modulus of elasticity of Bertholletia excelsa wood using the particle image velocimetry technique and the ultrasound method to compare the results with the conventional methodology. For this purpose, samples of Bertholletia excelsa were made using a circular saw. The samples were evaluated for sound propagation to calculate the modulus of elasticity using ultrasound equipment. Subsequently, they were subjected to the compression parallel to grain test in a universal testing machine. The samples were marked and monitored during the loading session, with the repeated capture of images using a professional camera. The deformation values obtained were used to estimate the modulus of elasticity using the particle image velocimetry technique. The mean values of modulus of elasticity found were 17403 MPa for ultrasound, 15589 MPa for the particle image velocimetry technique, and 15333 MPa for the universal testing machine. The particle image velocimetry technique was considered to be statistically similar (Tukey α = 0,05) to the other methods tested. The linear coefficient of determination (R2) between the particle image velocimetry technique and the universal testing machine was 0,95, a high and satisfactory value. Thus, the particle image velocimetry technique and the ultrasound method are valid to estimate the modulus of elasticity of Bertholletia excelsa wood and possibly of woods with similar technological characteristics.

https://doi.org/10.4067/s0718-221x2022000100413 78 downloads

Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology
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BRUCKI, Sonia Maria Dozzi

; ADONI, Tarso

; ALMEIDA, Carlos Mauricio Oliveira

; ANDRADE, Daniel Ciampi de

; ANGHINAH, Renato

; BARBOSA, Luciana Mendonça

; BAZAN, Rodrigo

; CARVALHO, Alzira Alves de Siqueira

; CARVALHO, William

; CHRISTO, Paulo Pereira

; COLETTA, Marcus Della

; CONFORTO, Adriana Bastos

; CORREA-NETO, Ylmar

; ENGELHARDT, Eliasz

; FRANÇA JUNIOR, Marcondes Cavalcante

; FRANCO, Clelia

; VON GLEHN, Felipe

; GOMES, Helio Rodrigues

; HOULY, Caroline Gomes de Barros

; KAUP, Alexandre Ottoni

; KOWACS, Fernando

; KANASHIRO, Aline

; LOPES, Victor Gonçalves

; MAIA, Débora

; MANREZA, Maria

; MARTINEZ, Alberto Rolim Muro

; MARTINEZ, Sandra Cristina Gonçalves

; NADER, Saulo Nardy

; NEVES, Luciana de Oliveira

; OKAMOTO, Ivan Hideyo

; OLIVEIRA, Rogério Adas Ayres de

; PEIXOTO, Fabiano de Melo

; PEREIRA, Cristiana Borges

; SABA, Roberta Arb

; SAMPAIO, Leticia Pereira de Brito

; SCHILLING, Lucas Porcello

; SILVA, Marcus Tulius Teixeira

; SILVA, Emanuelle Roberta

; SMID, Jerusa

; SOARES, Cristiane Nascimento

; SOBREIRA-NETO, Manoel

; SOUSA, Nise Alessandra de Carvalho

; SOUZA, Leonardo Cruz de

; TEIVE, Hélio Afonso Ghizoni

; TERRA, Vera Cristina

; VALE, Matheus

; VIEIRA, Vitor Mendes Grise

; ZANOTELI, Edmar

; PRADO, Gilmar

Arquivos de Neuro-Psiquiatria

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apr 2021, Volume 79 N. 4 Pages 354 - 369

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Os canabinoides compreendem os endocanabinoides, fitocanabinoides e os canabinoides sintéticos e desempenham ações no sistema nervoso central e periférico. Uma quantidade enorme de publicações tem sido lançada nos últimos anos, embora a cannabis seja conhecida por milênios. Os Departamentos Científicos da Academia Brasileira de Neurologia descreveram as evidências do uso médico em suas áreas. A literatura está em constantes mudanças e possíveis novas evidências podem surgir nos próximos dias ou meses. A prescrição dessas substâncias deve ser discutida com os pacientes e suas famílias, com conhecimento sobre eventos adversos e sua eficácia.

ABSTRACT Cannabinoids comprehend endocannabinoids, phytocannabinoids, and synthetic cannabinoids, with actions both in the central and peripherical nervous systems. A considerable amount of publications have been made in recent years, although cannabis has been known for over a thousand years. Scientific Departments from the Brazilian Academy of Neurology described evidence for medical use in their areas. Literature is constantly changing, and possible new evidence can emerge in the next days or months. Prescription of these substances must be discussed with patients and their families, with knowledge about adverse events and their efficacy.

https://doi.org/10.1590/0004-282x-anp-2020-0432 1049 downloads

“Half-Sandwich”/RuII Anticancer Complexes Containing Triphenylphosphine and p-Substituted Benzoic Acids
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Honorato, João

; Oliveira, Katia M.

; Leite, Celisnolia M.

; Colina-Vegas, Legna

; Nóbrega, Joaquim A.

; Castellano, Eduardo E.

; Ellena, Javier

; Correa, Rodrigo S.

; Batista, Alzir A.

Journal of the Brazilian Chemical Society

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nov 2020, Volume 31 N. 11 Pages 2237 - 2249

Abstract: En | Text: En | PDF: En

Mononuclear and binuclear RuII/arene/triphenylphosphine complexes with p-substituted benzoic acid derivatives were prepared and characterized. These monocationic complexes of type [Ru(η6-p-cymene)(PPh3)L] (L = benzoic acid (1), p-hydroxybenzoic acid (2), p-nitrobenzoic acid (3) and terephthalic acid (4)) were characterized using various techniques, such as nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry, and the crystal structure of 1, 3 and 4 were determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated, in vitro, against tumorigenic [MDA-MB-231, MCF-7 (breast), A549 (lung) and DU-145 (prostate)] and non-tumorigenic [MCF-10A (breast), MRC-5 (lung) and PNT-2 (prostate)] cells. The binuclear complex (4) was inactive due to its low solubility. Complexes 1, 2 and 3 showed similar cytotoxicity, however, complex 1 presented better selectivity index against MDA-MB-231 than compounds 2 and 3. Cellular ruthenium absorption was explored by inductively coupled plasma mass spectrometry (ICP-MS) analyzing the whole cells and the culture medium. Complementary studies showed that complex 1 inhibited colony formation, induced morphology changes in cells and promoted cell cycle arrest in the Sub-G1 phase for the MDA-MB-231 cells.

https://doi.org/10.21577/0103-5053.20200076 409 downloads

Management of acute stroke and urgent neurointerventional procedures during COVID-19 pandemic: recommendations on the Scientific Department on Cerebrovascular Diseases of the Brazilian Academy of Neurology, Brazilian Society of Cerebrovascular Diseases and Brazilian Society of Neuroradiology
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MONT’ALVERNE, Francisco José Arruda

; LIMA, Fabrício Oliveira

; NOGUEIRA, Raul Gomes

; FREITAS, Carlos Clayton Macedo de

; NETO, Octávio Marques Pontes

; SILVA, Gisele Sampaio

; OLIVEIRA, Maura Salaroli de

; FRUDIT, Michel

; CALDAS, Jose Guilherme Mendes Pereira

; ABUD, Daniel Giansante

; CONFORTO, Adriana Bastos

; CARVALHO, Fernanda Martins Maia

; DIAS, Francisco Antunes

; BAZAN, Rodrigo

; AVELAR, Wagner Mauad

; MORO, Carla Heloísa Cabral

; MAGALHÃES, Pedro Silva Correa de

; MIRANDA, Maramelia

; BARBOSA, Leandro de Assis

; FIOROT JUNIOR, José Antonio

; CARDOSO, Fabrício Buchdid

; REBELLO, Leticia Costa

; PARENTE, Bruno de Sousa Mendes

; FARIA, Mário de Barros

; FREITAS, Gabriel Rodriguez de

; ZÉTOLA, Viviane de Hiroki Flumignan

; OLIVEIRA-FILHO, Jamary

; BEZERRA, Daniel da Cruz

; RODRIGUES, Jorge Luis Nobre

; KUSTER, Gustavo

; MARTINS, Sheila

; CARVALHO, João José Freitas de

Arquivos de Neuro-Psiquiatria

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jul 2020, Volume 78 N. 7 Pages 440 - 449

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: A pandemia causada pelo novo coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2, COVID-19) apresenta novos e importantes desafios à gestão de saúde no Brasil. Além da difícil missão de prestar atendimento aos milhares de pacientes infectados pelo COVID-19, os sistemas de saúde têm que manter a assistência às emergências médicas comuns em períodos sem pandemia, tais como o acidente vascular cerebral (AVC), que continuam ocorrendo e requerem tratamento com presteza e eficiência. A alocação de recursos materiais e humanos para o enfrentamento à pandemia não pode comprometer o atendimento ao AVC agudo, uma emergência cujo tratamento é tempo-dependente e se não realizado implica em importante impacto na mortalidade e incapacitação a longo prazo. Objetivo: Este trabalho resume as recomendações do Departamento Científico de Doenças Cerebrovasculares da Academia Brasileira de Neurologia, da Sociedade Brasileira de Doenças Cerebrovasculares e da Sociedade Brasileira de Neurorradiologia para o tratamento do AVC agudo e para a realização de procedimentos de neurointervenção urgentes durante a pandemia de COVID-19, incluindo o uso adequado de ferramentas de triagem e equipamentos de proteção pessoal (para pacientes e profissionais de saúde), além da alocação apropriada de pacientes.

ABSTRACT Introduction: Although the 2019 severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2, COVID-19) pandemic poses new challenges to the healthcare system to provide support for thousands of patients, there is special concern about common medical emergencies, such as stroke, that will continue to occur and will require adequate treatment. The allocation of both material and human resources to fight the pandemic cannot overshadow the care for acute stroke, a time-sensitive emergency that with an inefficient treatment will further increase mortality and long-term disability. Objective: This paper summarizes the recommendations from the Scientific Department on Cerebrovascular Diseases of the Brazilian Academy of Neurology, the Brazilian Society of Cerebrovascular Diseases and the Brazilian Society of Neuroradiology for management of acute stroke and urgent neuro-interventional procedures during the COVID-19 pandemic, including proper use of screening tools, personal protective equipment (for patients and health professionals), and patient allocation.

https://doi.org/10.1590/0004-282x20200053 2310 downloads

10.

IgE antibodies from schistosomiasis patients to recognize epitopes in potato apyrase
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Gusmão, Michélia Antônia do Nascimento

; Emídio, Nayara Braga

; Marconato, Danielle Gomes

; Farani, Priscila Silva Grijó

; Maniezzi, Luiz Felipe

; Coelho, Paulo Marcos Zech

; Oliveira, Rodrigo Correa

; Vasconcelos, Eveline Gomes

; Faria-Pinto, Priscila de

Revista da Sociedade Brasileira de Medicina Tropical

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2019, Volume 52 elocation e20180139

Abstract: En | Text: En | PDF: En

Abstract INTRODUCTION: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase and Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence of particular epitopes shared between these proteins. METHODS: Potato apyrase was employed using ELISA, western blot, and mouse immunization methods to verify IgE reactivity. RESULTS: Most of the schistosomiasis patient’s (75%) serum was seropositive for potato apyrase and this protein was recognized using western blotting, suggesting that parasite and plant proteins share IgE-binding epitopes. C57BL/6 mice immunized with potato apyrase showed increased IgE antibody production. CONCLUSIONS: Potato apyrase and SmATPDases have IgE-binding epitopes.

https://doi.org/10.1590/0037-8682-0139-2018 896 downloads

11.

PRODUCTIVE PERFORMANCE OF PRE-WEANED CALVES REARED IN THE PANTANAL
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Oliveira, Luiz Orcirio Fialho de

; Abreu, Urbano Gomes Pinto de

; Gomes, Rodrigo da Costa

; Nogueira, Ériklis

; Silva, Juliana Correa Borges

; Costa, Tereza Gabriela

Ciência Animal Brasileira

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2019, Volume 20 elocation e-51187

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A desmama precoce (DP) vem sendo adotada nas fazendas de cria do Pantanal como alternativa para o aumento dos índices de concepção das vacas. A principal receita dessas propriedades são os bezerros (as), sendo o seu valor dependente dos seus respectivos pesos. Assim é necessário que os bezerros submetidos à DP, apresentem pesos semelhantes ou acima dos bezerros desmamados convencionalmente. Desta forma o estudo teve como objetivo, acompanhar o desempenho de bezerros nascidos no Pantanal, submetidos à DP ou a desmama convencional (DC), puros (Nelore) ou Cruzados (Nelore/Angus). Após a DP os animais receberam suplemento específico para bezerros, na quantidade fixa de 1 kg/animal/dia (baixa energia) ou ao nível de 1% do Peso Vivo (alta energia). Os pesos ajustados aos 300 dias de idade foram maiores para os bezerros de DP sob alta energia (P<0,01), em ambos os grupos genéticos. Os pesos dos animais de DP de baixa energia e de DC, não se diferiram (P>0,01), sendo de 241,17 e 236,27 kg para o grupo de bezerros Cruzados e de 184,44 e 189,78 para o grupo de bezerros Nelore respectivamente. A DP adotada no modelo experimental não prejudicou o desempenho dos bezerros nascidos no Pantanal.

Abstract Early weaning (EW) has been adopted in cattle breeding farms in Pantanal as a strategy to increase the rate of pregnancy in cows. The primary income of these properties is the production of beef calves, and the price of these animals depends on their weight. Therefore, the calves subjected to EW should present weight similar to or higher than those of calves subjected to conventional weaning (CW). This study aimed to evaluate the productive performance of pure (Nellore) calves and crossbred (Nellore/Angus) calves reared in the Pantanal and subjected to either EW or CW. After EW, the calves were supplemented with concentrate at 1 kg/animal/day (low-energy diet) or 1% of live weight (high-energy diet). The weights adjusted to 300 days of age were higher for EW calves fed the high-energy diet (p<0.01) in both genetic groups. No significant differences were observed in the weight of EW animals fed the low-energy diet and CW animals (p>0.01), and animal weight was 241.17 and 236.27 kg in crossbred calves and 184.44 and 189.78 in Nellore calves, respectively. The EW adopted in this experimental model did not affect the productive performance of calves raised in the Pantanal.

https://doi.org/10.1590/1809-6891v20e-51187 1315 downloads

12.

Qualidade de vida pós-unidades de terapia intensiva: protocolo de estudo de coorte multicêntrico para avaliação de desfechos em longo prazo em sobreviventes de internação em unidades de terapia intensiva brasileiras
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Robinson, Caroline Cabral

; Rosa, Regis Goulart

; Kochhann, Renata

; Schneider, Daniel

; Sganzerla, Daniel

; Dietrich, Camila

; Sanchez, Évelin Carneiro

; Dutra, Francine Hoffmann

; Oliveira, Maicon Quadro de

; Anzolin, Luisa Barbosa

; Menezes, Suelen Fardim de

; Jeffman, Rodrigo

; Souza, Denise de

; Silva, Sâmia Faria da

; Cruz, Luciane Nascimento

; Boldo, Rodrigo

; Cardoso, Juliana Rezende

; Birriel, Daniella Cunha

; Gamboa, Mariana Nunes

; Machado, André Sant'Ana

; Andrade, Juliana Mara Stormosvski de

; Alencar, Cesar

; Teixeira, Michelle Carneiro

; Vieira, Silvia Regina Rios

; Moreira, Fernanda Caleffe

; Amaral, Alexandre

; Silveira, Ana Paula Menezes

; Teles, José Mario Meira

; Oliveira, Daniela Cunha de

; Oliveira Júnior, Lúcio Couto de

; Castro, Lívia Correa e

; Silva, Marli Sarmento da

; Neves, Rafael Trevizoli

; Gomes, Renata de Andrade

; Ribeiro, Cinthia Mucci

; Cavalcanti, Alexandre Biasi

; Oliveira, Roselaine Pinheiro de

; Maccari, Juçara Gasparetto

; Berto, Paula Pinheiro

; Martins, Lucieda Araújo

; Santos, Rui Leandro da Silva

; Ue, Luciana Yumi

; Hammes, Luciano Serpa

; Sharshar, Tarek

; Bozza, Fernando

; Falavigna, Maicon

; Teixeira, Cassiano

Revista Brasileira de Terapia Intensiva

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dec 2018, Volume 30 N. 4 Pages 405 - 413

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar a prevalência de incapacidades físicas, cognitivas e psiquiátricas, fatores associados e sua relação com qualidade de vida em pacientes sobreviventes de internação em unidades de terapia intensiva brasileiras. Métodos: Um estudo de coorte prospectivo multicêntrico está sendo conduzido em dez unidades de terapia intensiva adulto clínico-cirúrgicas representativas das cinco regiões geopolíticas do Brasil. Pacientes com idade ≥ 18 anos que receberam alta das unidades de terapia intensiva participantes e permaneceram internados na unidade de terapia intensiva por 72 horas ou mais, nos casos de internação clínica ou cirúrgica de urgência, e por 120 horas ou mais, nos casos de internação cirúrgica eletiva, serão incluídos de forma consecutiva. Estes pacientes serão seguidos por 1 ano, por meio de entrevistas telefônicas estruturadas 3, 6 e 12 meses pós-alta da unidade de terapia intensiva. Dependência funcional, disfunção cognitiva, sintomas de ansiedade e depressão, sintomas de estresse pós-traumático, qualidade de vida relacionada à saúde, re-hospitalizações e mortalidade em longo prazo serão avaliados como desfechos. Discussão: O presente estudo tem o potencial de contribuir para o conhecimento a respeito da prevalência e dos fatores associados à síndrome pós-cuidados intensivos na população de pacientes adultos sobreviventes de internação em unidades de terapia intensiva brasileiras. Ademais, a associação entre síndrome pós-cuidados intensivos e qualidade de vida relacionada à saúde poderá ser estabelecida.

ABSTRACT Objective: To establish the prevalence of physical, cognitive and psychiatric disabilities, associated factors and their relationship with the qualities of life of intensive care survivors in Brazil. Methods: A prospective multicenter cohort study is currently being conducted at 10 adult medical-surgical intensive care units representative of the 5 Brazilian geopolitical regions. Patients aged ≥ 18 years who are discharged from the participating intensive care units and stay 72 hours or more in the intensive care unit for medical or emergency surgery admissions or 120 hours or more for elective surgery admissions are consecutively included. Patients are followed up for a period of one year by means of structured telephone interviews conducted at 3, 6 and 12 months after discharge from the intensive care unit. The outcomes are functional dependence, cognitive dysfunction, anxiety and depression symptoms, posttraumatic stress symptoms, health-related quality of life, rehospitalization and long-term mortality. Discussion: The present study has the potential to contribute to current knowledge of the prevalence and factors associated with postintensive care syndrome among adult intensive care survivors in Brazil. In addition, an association might be established between postintensive care syndrome and health-related quality of life.

https://doi.org/10.5935/0103-507x.20180063 7824 downloads

13.

Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts
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Carvalho, Ana Paula Mendes

; Coelho, Angélica da Conceição Oliveira

; Correa-Oliveira, Rodrigo

; Lana, Francisco Carlos Félix

Memórias do Instituto Oswaldo Cruz

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sep 2017, Volume 112 N. 9 Pages 609 - 616

Abstract: En | Text: En | PDF: En

BACKGROUND There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals. OBJECTIVE The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disaccharide linked to human serum albumin via an octyl (NDOHSA), a semisynthetic phenolic glycolipid-I (PGL-I); Leprosy Infectious Disease Research Institute Diagnostic-1 (LID-1) and natural disaccharide octyl - Leprosy Infectious Disease Research Institute Diagnostic-1 (NDOLID). METHODS The study population consisted of 130 leprosy cases diagnosed between 2010 and 2015 and 277 household contacts. An enzyme-linked immunosorbent assay (ELISA) was used to analyse the reactivity of antibodies against NDOHSA, LID-1 and NDOLID. The samples and controls were tested in duplicate, and the antibody titer was expressed as an ELISA index. Data collection was made by home visits with application of questionnaire and dermatological evaluation of all household contacts to identify signs and symptoms of leprosy. FINDINGS Significant differences in the median ELISA results were observed among leprosy cases in treatment, leprosy cases that had completed treatment and household contacts. Higher proportions of seropositivity were observed in leprosy cases in treatment. Seropositivity was also higher in multibacillary in relation to paucibacillary, with the difference reaching statistical significance. Lower titers were observed among cases with a longer treatment time or discharge. For household contacts, the differences according to the clinical characteristics of the leprosy index case were less pronounced than expected. Other factors, such as the endemicity of leprosy, exposure outside the residence and genetic characteristics, appeared to have a greater influence on the seropositivity. MAIN CONCLUSIONS Serologic tests could be used as auxiliary tools for determining the operational classification, in addition to identifying infected individuals and as a strategy for surveillance of household contacts.

https://doi.org/10.1590/0074-02760160505 1329 downloads

14.

Brazilian guidelines for the diagnosis and treatment of cystic fibrosis
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Athanazio, Rodrigo Abensur

; Silva Filho, Luiz Vicente Ribeiro Ferreira da

; Vergara, Alberto Andrade

; Ribeiro, Antônio Fernando

; Riedi, Carlos Antônio

; Procianoy, Elenara da Fonseca Andrade

; Adde, Fabíola Villac

; Reis, Francisco José Caldeira

; Ribeiro, José Dirceu

; Torres, Lídia Alice

; Fuccio, Marcelo Bicalho de

; Epifanio, Matias

; Firmida, Mônica de Cássia

; Damaceno, Neiva

; Ludwig-Neto, Norberto

; Maróstica, Paulo José Cauduro

; Rached, Samia Zahi

; Melo, Suzana Fonseca de Oliveira

; Pinto, Leonardo Araújo

; Monte, Luciana Freitas Velloso

; Higa, Laurinda Yoko Shinzato

; Folescu, Tania Wrobel

; Marson, Fernando Augusto de Lima

; Sad, Isabela

; Servidoni, Maria de Fátima Correa Pimenta

; Kussek, Paulo

; Raskin, Salmo

; Zuana, Adriana Della

; Augustin, Albin

; Hoffmann, Anneliese

; Barbisan, Beatriz

; Hochhegger, Bruno

; Levy, Carlos Emilio

; Veiga, Claudine Sarmento da

; Ricachinevsky, Claudio

; Esposito, Concetta

; Escuissato, Dante

; Brandemburgo, Diego

; Marques, Elisabeth

; Aquino, Evanirso de

; Fischer, Gilberto Bueno

; Rodrigues, Joaquim Carlos

; Machado, Leticia

; Muramato, Lucia

; Costa, Lusmaia Damasceno Camargo

; Donadio, Marcio

; Castro, Marcos César Santos de

; Ribeiro, Maria Angela

; Santana, Maria Angélica

; Canan, Mariane

; Almeida, Marina Buarque de

; Britto, Murilo

; Dalcin, Paulo Roth Tarso

; Ramos, Regina Terse Trindade

; Chiba, Sonia

; Martins, Valéria de Carvalho

; Lacerda, Claudine

; Barbosa, Eliana

; Guimarães, Elizabet Vilar

; Hessel, Gabriel

; Gurmini, Jocemara

; Neri, Lenycia

; Nogueira, Marcelo Coelho

; Wayhs, Mônica Chang

; Simon, Miriam Isabel Santos

; Fernandes, Arlene Gonçalves dos Santos

; Silva, Claudia de Castro de

; Albuquerque, Cristiano Túlio Maciel

; Souza, Edna Lúcia

; Silva, Fernando Antonio de Abreu e

; Dalcin, Paulo de Tarso

; Noronha, Renata Maria de

; Teixeira, Ricardo

; Machado, Sandra Helena

; Camargo, Spencer Marcantonio

; Rozov, Tatiana

; Rodrigues, Ticiana da Costa

Jornal Brasileiro de Pneumologia

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jun 2017, Volume 43 N. 3 Pages 219 - 245

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A fibrose cística (FC) é uma doença genética autossômica recessiva caracterizada pela disfunção do gene CFTR. Trata-se de uma doença multissistêmica que ocorre mais frequentemente em populações descendentes de caucasianos. Nas últimas décadas, diversos avanços no diagnóstico e tratamento da FC mudaram drasticamente o cenário dessa doença, com aumento expressivo da sobrevida e qualidade de vida. Atualmente, o Brasil dispõe de um programa de ampla cobertura para a triagem neonatal de FC e centros de referência distribuídos na maior parte desses estados para seguimento dos indivíduos. Antigamente confinada à faixa etária pediátrica, tem-se observado um aumento de pacientes adultos com FC tanto pelo maior número de diagnósticos de formas atípicas, de expressão fenotípica mais leve, assim como pelo aumento da expectativa de vida com os novos tratamentos. Entretanto, ainda se observa uma grande heterogeneidade no acesso aos métodos diagnósticos e terapêuticos para FC entre as diferentes regiões brasileiras. O objetivo dessas diretrizes foi reunir as principais evidências científicas que norteiam o manejo desses pacientes. Um grupo de 18 especialistas em FC elaborou 82 perguntas clínicas relevantes que foram divididas em cinco categorias: características de um centro de referência; diagnóstico; tratamento da doença respiratória; tratamento gastrointestinal e nutricional; e outros aspectos. Diversos profissionais brasileiros atuantes na área da FC foram convidados a responder as perguntas formuladas pelos coordenadores. A literatura disponível foi pesquisada na base de dados PubMed com palavras-chave, buscando-se as melhores respostas às perguntas dos autores.

ABSTRACT Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by dysfunction of the CFTR gene. It is a multisystem disease that most often affects White individuals. In recent decades, various advances in the diagnosis and treatment of CF have drastically changed the scenario, resulting in a significant increase in survival and quality of life. In Brazil, the current neonatal screening program for CF has broad coverage, and most of the Brazilian states have referral centers for the follow-up of individuals with the disease. Previously, CF was limited to the pediatric age group. However, an increase in the number of adult CF patients has been observed, because of the greater number of individuals being diagnosed with atypical forms (with milder phenotypic expression) and because of the increase in life expectancy provided by the new treatments. However, there is still great heterogeneity among the different regions of Brazil in terms of the access of CF patients to diagnostic and therapeutic methods. The objective of these guidelines was to aggregate the main scientific evidence to guide the management of these patients. A group of 18 CF specialists devised 82 relevant clinical questions, divided into five categories: characteristics of a referral center; diagnosis; treatment of respiratory disease; gastrointestinal and nutritional treatment; and other aspects. Various professionals working in the area of CF in Brazil were invited to answer the questions devised by the coordinators. We used the PubMed database to search the available literature based on keywords, in order to find the best answers to these questions.

https://doi.org/10.1590/s1806-37562017000000065 75529 downloads

15.

Mesenchymal stem cell therapy promotes the improvement and recovery of renal function in a preclinical model
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Urt-Filho, Antônio

; Oliveira, Rodrigo Juliano

; Hermeto, Larissa Correa

; Pesarini, João Renato

; David, Natan de

; Cantero, Wilson de Barros

; Falcão, Gustavo

; Marks, Guido

; Antoniolli-Silva, Andréia Conceição Milan Brochado

Genetics and Molecular Biology

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jun 2016, Volume 39 N. 2 Pages 290 - 299

Abstract: En | Text: En | PDF: En

Abstract Acute renal failure (ARF) is an extremely important public health issue in need of novel therapies. The present study aimed to evaluate the capacity of mesenchymal stem cell (MSC) therapy to promote the improvement and recovery of renal function in a preclinical model. Wistar rats were used as the experimental model, and our results show that cisplatin (5mg/kg) can efficiently induce ARF, as measured by changes in biochemical (urea and creatinine) and histological parameters. MSC therapy performed 24h after the administration of chemotherapy resulted in normalized plasma urea and creatinine levels 30 and 45d after the onset of kidney disease. Furthermore, MSC therapy significantly reduced histological changes (intratubular cast formation in protein overload nephropathy and tubular hydropic degeneration) in this ARF model. Thus, considering that current therapies for ARF are merely palliative and that MSC therapy can promote the improvement and recovery of renal function in this model system, we suggest that innovative/alternative therapies involving MSCs should be considered for clinical studies in humans to treat ARF.

https://doi.org/10.1590/1678-4685-gmb-2015-0178 2075 downloads

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