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RESUMO: Com a finalidade de estabelecer protocolos que possam contribuir na propagação de plantas medicinais, objetivamos, com este estudo, avaliar o efeito do hidrocondicionamento e substratos na emergência e produção de mudas de Calendula officinalis L. As sementes foram submetidas ou não ao hidrocondicionamento durante 24 horas, e posterior semeadura em quatro substratos: S1) 100% Latossolo Vermelho Distroférrico - LVD, S2) LVD + areia grossa (1:1, v/v), S3) LVD + substrato comercial Tropstrato® (1:1, v/v) e S4) 100% Tropstrato®, e mantidas em viveiro com 50% de sombreamento. Observamos maior percentagem de emergência nos substratos com presença de LVD. O hidrocondicionamento das sementes prejudicou a emergência das plântulas, mas contribuiu no crescimento de raiz, produção de biomassa e qualidade das mudas. O substrato 100% Tropstrato® favoreceu maior produção de massa seca e qualidade das mudas. Observamos correlação linear positiva (≥ 0,70) entre as características de crescimento da parte aérea e raiz com produção de biomassa e o índice de qualidade de Dickson. A análise de componentes principais explicou 78,95% da variância experimental, excluindo a primeira contagem e a relação parte aérea/raiz com baixa representatividade. Na análise de agrupamento das distâncias Euclidianas, as mudas com maior similaridade foram aquelas produzidas no 100% LVD e LVD + Tropstrato® com e sem hidrocondicionamento, respectivamente. Recomenda-se o Latossolo Vermelho Distroférrico puro ou combinado com Tropstrato® para a produção de mudas de C. officinalis L., e o hidrocondicionamento prejudicou as características de emergência das plântulas. RESUMO medicinais objetivamos estudo L 2 horas S1 S 100 S2 11, 11 1 1, (1:1 v/v, vv v/v , v S3 Tropstrato S4 50 sombreamento plântulas ≥ ( 0,70 070 0 70 Dickson 7895 78 95 78,95 experimental aérearaiz representatividade Euclidianas respectivamente Recomendase Recomenda se C 10 (1: 5 0,7 07 7 789 9 78,9 (1 0, 78,

ABSTRACT: In order to establish protocols that can contribute to the propagation of medicinal plants, this study evaluated the effect of hydropriming and substrates on the emergence and production of Calendula officinalis L. seedlings. Seeds were submitted or not to hydropriming for 24 hours, and subsequent sowing in four substrates: S1) 100% Dystroferric Red Latosol - DRL, S2) DRL + coarse sand (1:1 v/v), S3) DRL + Tropstrato® commercial substrate (1:1 v/v) and S4) 100% Tropstrato®, and kept in greenhouse with 50% shading. Higher emergence percentage in substrates with the presence of DRL was observed. Seed hydropriming impaired seedling emergence, but contributed to root growth, biomass production and seedling quality. The 100% Tropstrato® substrate favored higher dry mass production and seedling quality. Positive linear correlation (≥ 0.70) was observed between shoot and root growth characteristics with biomass production and Dickson’s quality index. Principal component analysis explained 78.95% of the experimental variance, excluding the first count and the shoot/root ratio with low representativeness. In the cluster analysis of Euclidean distances, seedlings with the greatest similarity were those produced with 100% DRL and DRL + Tropstrato® with and without hydropriming, respectively. Dystroferric Red Latosol is recommended pure or combined with Tropstrato® for the production of C. officinalis L seedlings, and the hydropriming impaired seedling emergence characteristics. ABSTRACT plants 2 hours S1 S 100 S2 11 1 (1: v/v, vv v/v , v S3 Tropstrato S4 50 shading ≥ ( 0.70 070 0 70 Dicksons Dickson s index 7895 78 95 78.95 variance shootroot representativeness distances respectively C 10 (1 5 0.7 07 7 789 9 78.9 0. 78.

https://doi.org/10.1590/0103-8478cr20230166

Pharmacologic Treatment of Obesity in adults and its impact on comorbidities: 2024 Update and Position Statement of Specialists from the Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso) and the Brazilian Society of Endocrinology and Metabolism (SBEM) comorbidities 202 Abeso (Abeso SBEM (SBEM 20 2
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Moreira, Rodrigo O.

; Valerio, Cynthia M.

; Hohl, Alexandre

; Moulin, Cristiane

; Moura, Fábio

; Trujilho, Fábio R.

; Gerchman, Fernando

; Correa, Livia L.

; Mancini, Marcio C.

; Melo, Maria Edna

; Lamounier, Rodrigo N.

; van de Sande-Lee, Simone

; Trujilho, Thaísa D. G.

; Miranda, Paulo A. C.

; Halpern, Bruno

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e240422

Abstract: En | Text: En | PDF: En

ABSTRACT Pharmacological treatment of obesity is passing through many changes in the last decades; different agents have been approved, and newer options are leaning towards higher efficacy and a more favourable safety profile; however, medications approved for a longer time are still available and useful for many patients. This document is an 2024 Update Position Statement of Specialists from the Brazilian Association for the Study of Obesity and Metabolic Syndrome (Abeso) and the Brazilian Society of Endocrinology and Metabolism (SBEM), with the aim of reviewing all the approved medications for the management of obesity in Brazil (sibutramine, orlistat, liraglutide, semaglutide and bupropion/naltrexone fixed dose), with the addition of tirzepatide, that is approved in other countries and likely approved soon in Brazil. The review is focused on efficacy, safety profile and the impact of drugs (based on existing studies) on different comorbidities. decades however patients 202 Abeso (Abeso SBEM, SBEM , (SBEM) sibutramine, sibutramine (sibutramine orlistat liraglutide bupropionnaltrexone bupropion naltrexone dose, dose dose) tirzepatide based studies comorbidities 20 (SBEM 2

https://doi.org/10.20945/2359-4292-2024-0422

Evaluation of the potential for greenhouse gas (CO2, CH4) emissions in the southern São Paulo coastal region, Cananéia-Iguape system CO2, CO2 CO (CO2 CH4 CH region CananéiaIguape Cananéia Iguape (CO
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Araujo, Elaine C.

; Correa, Thais

; Andrade, Izabel da S.

; Macedo, Fernanda de M.

; Marques, Marcia T.

; Andrade, Thais

; Souto-Oliveira, Carlos Eduardo

; Braga, Elisabete S.

; Andrade, Maria de F.

; Landulfo, Eduardo

Ocean and Coastal Research

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2024, Volume 72 elocation e24036

Abstract: En | Text: En | PDF: En

ABSTRACT The emissions of CH4 and CO2, the primary greenhouse gases, have a significant impact on radiative forcing. This study investigated these gases along the Cananéia-Iguape estuarine system on the southern coast of the State of São Paulo, Brazil, which is a mangrove region characterized by low anthropogenic impact and a sparse population. As such, this area provides an ideal location for identifying natural emissions and background concentrations. The data for this study were collected using a portable gas analyzer (LGR-ICOSTM GLA131), known for its high sensitivity and precision in detecting gases, mounted on a research boat. The results obtained were promising for both gases. A small variability in CH4 concentrations was observed along the route, ranging from 1.84 ppm to 1.95 ppm, while CO2, showed greater variation in values obtained during routes, ranging from approximately 411 ppm to 575 ppm. This study underscores the importance of investigating areas with minimal environmental impact. Together with future analyses, this research should help improve Greenhouse Gas (GHG) inventories in Brazil by providing valuable baseline data for comparisons with more impacted areas. CH CO2 CO forcing CananéiaIguape Cananéia Iguape Paulo population such LGRICOSTM LGR ICOSTM GLA131, GLA131 GLA , GLA131) boat route 184 1 84 1.8 195 95 1.9 routes 41 57 analyses GHG (GHG GLA13 18 8 1. 19 9 4 5 GLA1

https://doi.org/10.1590/2675-2824072.22121

Thyroid hormone profile is related to prognosis in acute decompensation of cirrhosis
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Nardin, Giovana De

; Colombo, Bruno da Silveira

; Ronsoni, Marcelo Fernando

; Silva, Pedro Eduardo Soares e

; Fayad, Leonardo

; Wildner, Letícia Muraro

; Bazzo, Maria Luiza

; Dantas-Correa, Esther Buzaglo

; Narciso-Schiavon, Janaína Luz

; Schiavon, Leonardo de Lucca

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230249

Abstract: En | Text: En | PDF: En

ABSTRACT Objective To investigate the prognostic significance of thyroid hormone profile in patients hospitalized for decompensated cirrhosis. Subjects and methods Prospective cohort study that included 119 subjects. All subjects were evaluated at admission and followed for 90 days. TSH, fT3, fT4 were measured within 24 hours of hospitalization. Results Higher fT4 and lower fT3 levels were observed among Child-Pugh C patients as compared to Child-Pugh A and B, and in those with acute-on-chronic liver failure (ACLF). Lower fT3/fT4 ratio was observed in those with ascites, infections, ACLF, and in Child-Pugh C. Ninety-day mortality was 26.9% and it was independently associated with higher Model for End-stage Liver Disease (MELD) and TSH, and lower fT3/fT4 ratio in multivariate analysis. A new prognostic model including MELD, TSH and fT3/fT4 ratio was devised. The areas under the receiver operating characteristic curves for MELD, fT3/fT4 ratio, TSH (μIU/mL), and the new model for predicting 90-day mortality were 0.847 ± 0.041, 0.841 ± 0.039, 0.658 ± 0.062, and 0.899 ± 0.031, respectively. The 90-day survival was 31.6% in patients with values of the predictive model ≥ -0.77 and 93.5% for values < -0.77 (P < 0.001). Conclusions Thyroid hormone profile was strongly associated with worse outcomes in patients with cirrhosis and might represent promising prognostic tools that can be incorporated in clinical practice. 11 9 days fT 2 hospitalization ChildPugh Child Pugh B acuteonchronic acute on chronic ACLF. ACLF . (ACLF) fT3fT4 fTfT fT3/fT ascites infections Ninetyday Ninety day 269 26 26.9 Endstage End stage MELD (MELD analysis devised μIU/mL, μIUmL μIU/mL , μIU mL (μIU/mL) 90day 0847 0 847 0.84 0041 041 0.041 0841 841 0039 039 0.039 0658 658 0.65 0062 062 0.062 0899 899 0.89 0031 031 0.031 respectively 316 31 6 31.6 0.77 077 77 -0.7 935 93 5 93.5 P 0.001. 0001 0.001 001 0.001) practice 1 (ACLF fT3fT 26. (μIU/mL 084 84 0.8 004 04 0.04 003 03 0.03 065 65 0.6 006 06 0.06 089 89 3 31. 0.7 07 7 -0. 93. 000 0.00 00 08 8 0. 0.0 -0 -

https://doi.org/10.20945/2359-4292-2023-0249

Comparing the fibrosis inhibition effect of bevacizumab, 5-fluorouracil, and mitomycin C in trabeculectomy in dogs with glaucoma: A series of six cases
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Acevedo, Sandra Patricia

; Correa Valencia, Nathalia María

Revista Colombiana de Ciencias Pecuarias

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jul 2023, Volume 36 N. 3 Pages 109 - 120

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Anamnesis: A descriptive series of six cases of dogs with glaucoma are presented comparing the fibrosis inhibition effect of three drugs used during trabeculectomy (TEC). Clinical findings: The patients were diagnosed with primary chronic closed-angle glaucoma refractory to topical medical treatment with no pupillary light reflex and negative eyeblink response to threat and ocular pain. Therapeutic approach: Two patients received an intraoperative application of bevacizumab; two received 5-fluorouracil; and two, mitomycin C. Intraocular pressure (IOP) and filtering ampoule were observed on days 1, 7, 30, 60, and 90 post-surgery. Results and conclusion: Bevacizumab regulated IOP under 25 mmHg, constituting the drug of choice for dogs with primary closed-angle glaucoma without previous positive response to topical therapy and subjected to TEC, when compared with 5-fluorouracil and MMC regarding the inhibitory effect of fibrosis.

Resumen Anamnesis: Se presenta una serie descriptiva de seis casos de perros con glaucoma, con el objetivo de comparar el efecto de inhibición de la fibrosis tres principios farmacológicos aplicados durante la trabeculectomía (TEC). Hallazgos clínicos: Los pacientes obtuvieron un diagnóstico de glaucoma primario crónico de ángulo cerrado refractario al tratamiento médico tópico, sin reflejo pupilar a la luz y respuesta negativa de parpadeo ante amenaza y dolor ocular. Aproximación terapéutica: Dos pacientes recibieron aplicación intraoperatoria de bevacizumab, dos recibieron 5-fluorouracilo y dos, mitomicina C. La presión intraocular (PIO) y la ampolla filtrante se observaron los días 1, 7, 30, 60 y 90 de evolución posquirúrgica. Resultados y conclusión: El bevacizumab reguló la PIO por debajo de 25 mmHg, constituyéndose en el fármaco de elección para perros con glaucoma primario de ángulo cerrado sin respuesta positiva previa a la terapia tópica y sometidos a TEC, en comparación con 5-fluorouracilo y mitomicina C en cuanto a los efectos de inhibición de la fibrosis.

Resumo Anamnese: Apresenta-se uma série descritiva de seis casos de cães com glaucoma, com o objetivo de comparar o efeito da inibição da fibrose de três princípios farmacológicos aplicados durante a trabeculectomia (TEC). Achados clínicos: Os pacientes foram diagnosticados com glaucoma primário crônico de ângulo fechado, refratário ao tratamento medicamentoso tópico, sem reflexo pupilar à luz, piscamento negativo à ameaça e dor ocular. Abordagem terapêutica: Dois pacientes receberam aplicação intraoperatória de bevacizumabe, dois receberam 5-fluorouracil e dois mitomicina C. A pressão intraocular (PIO) e a bolha vazante foram observadas nos dias 1, 7, 30, 60 e 90 de pós-operatório. Resultados y conclusão: De acordo com nossos resultados, o bevacizumabe consegue regular a PIO abaixo de 25 mmHg e é a droga de escolha potencial em cães com glaucoma primário de ângulo fechado, sem resposta positiva prévia à terapia tópica e submetidos à TEC, quando comparado com 5-fluorouracil e mitomicina C em termos de efeitos de inibição de fibrose.

https://doi.org/10.17533/udea.rccp.v36n2a6

COMPARISON OF TWO MORPHOTYPES OF ZUCCAGNIA PUNCTATA (FABACEAE) FROM VALLES CALCHAQUÍES IN ARGENTINA
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Álvarez, María A.

; Uriburu, Florencia M. Correa

; Barrera, María C.

; Enrico, Roxana J.

; Andrada, Aldo R.

; Usandivaras, Gabriela M. Silenzi

; Páez, Valeria A.

; Caro, María S.

; Zampini, Iris C.

; Isla, María I.

Darwiniana, nueva serie

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jun 2023, Volume 11 N. 1 Pages 187 - 210

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Álvarez, M. A; F. M. Correa Uriburu, M. C. Barrera, R. J. Enrico, A. R. Andrada, G. M. Silenzi Usandivaras, V. A. Páez, M. S. Caro, I. C. Zampini & M. I. Isla. 2023. Comparison of two morphotypes of Zuccagnia punctata (Fabaceae) from Valles Calchaquíes in Argentina. Darwiniana, nueva serie 11(1): 139-154. Zuccagnia punctata Cav. (Fabaceae) is a medicinal aromatic shrub, a monotypic species with a wide distribution in Argentina. Two morphotypes were found in Valles Calchaquíes, one with yellow fruits (YF) and other with red-brown fruits (RBF). The color of fruits varies between individuals within a population, with some plants producing red-brown fruits and other yellow fruits. The cytogenetic differentiation was determined using root tips. Leaves and fruits were used to analyze chemical composition by HPLC-DAD and HPLC/MS/MS. The number of chromosome (2n = 24) was reported for the first time for the genus. The yellow fruits and red-brown fruits morphotypes showed different karyotypes. The compounds common to both morphotypes were identified in leaves and fruits as chalcones, compounds with biological activity and biomarkers used for quality control of Z. punctata products. Two chemotypes related to the color of the fruits, were detected. An anthocyanin, cyanidin 3-glucoside was found in red-brown fruits (4.75 mg.g-1 fruits) but not in yellow fruits. These is the first report on yellow fruits morphotype of Z. punctata and on presence of anthocyanins in Z. punctata red-brown fruits morphotype. This work contributes to the knowledge of Z. punctata, a native plant from Argentina with high economic potential to promote the regional economy.

Resumen Álvarez, M. A; F. M. Correa Uriburu, M. C. Barrera, R. J. Enrico, A. R. Andrada, G. M. Silenzi Usandivaras, V. A. Páez, M. S. Caro, I. C. Zampini & M. I. Isla. 2023. Comparación de dos morfotipos de Zuccagnia punctata (Fabaceae) en los Valles Calchaquíes en Argentina. Darwiniana, nueva serie 11(1): 139-154. Zuccagnia punctata Cav. (Fabaceae) es un arbusto aromático medicinal monotípico con amplia distribución en Argentina. En los Valles Calchaquíes se encontraron dos morfotipos, uno con frutos amarillos y otro con frutos marrón rojizo. El color de los frutos varía entre individuos de una misma población, observándose plantas que tienen frutos de color marrón rojizo y otras con frutos de color amarillo. La diferenciación citogenética fue determinada usando puntas de raíces mientras que las hojas y frutos se usaron para analizar la composición química por HPLC-DAD y HPLC/MS/MS. Se informó por primera vez el número cromosómico (2n = 24) para el género Zuccagnia. Ambos morfotipos mostraron diferentes cariotipos. Se identificaron chalconas como compuestos comunes en las hojas y frutos de ambos morfotipos. Las chalconas son consideradas biomarcadores en el control de calidad de productos a base de Z. punctata. Se detectaron dos quimiotipos relacionados al color de los frutos. La antocianina, cianidin 3-glucosido se encontró en frutos marrón rojizos (4.75 mg.g-1 fruto) pero no en frutos amarillos. Este es el primer informe sobre un morfotipo de Z. punctata con frutos amarillos y sobre la presencia de antocianinas en el morfotipo de frutos rojos. Este trabajo contribuye al conocimiento de Z. punctata, una planta nativa de Argentina con alto potencial económico para promover el desarrollo regional.

https://doi.org/10.14522/darwiniana.2023.111.1083

Hepatozoon Miller, 1908 parasites in the Colubridae snakes Clelia clelia (Daudin, 1803) and Drymarchon corais (Boie, 1827) from the Eastern Amazonia Miller 190 Daudin, Daudin (Daudin 1803 Boie, Boie (Boie 1827 19 180 182 1 18
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PICELLI, AMANDA MARIA

; SILVA, MARIA REGINA L.

; CORREA, JAMILLE KARINA C.

; PAIVA, GLEICIERLE R.

; PAULA, FABIANE R.

; HERNÁNDEZ-RUZ, EMIL JOSÉ

; OLIVEIRA, ELCIOMAR A.

; VIANA, LÚCIO ANDRÉ

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Suppl. 1 elocation e20220115

Abstract: En | Text: En | PDF: En

Abstract Based on the genetic, morphological, and morphometric data of blood gamonts, we identified Hepatozoon parasites in colubrid snakes sampled in the Eastern Amazon region. Hepatozoon trigeminum was detected in the mussurana snake Clelia clelia and exhibited wide and elongated gamonts (mean dimensions: 14.25±0.65 × 4.31±0.43 μm) with an evident parasitophorous vacuole. Hepatozoon odwyerae sp. nov. was described in the indigo snake Drymarchon corais, whose gamonts have elongated and thin bodies (mean dimensions: 13.41±0.79 × 3.72±0.35 μm) with one end more tapered than the other. Phylogenetic analyses, based on the amplification of a 441 bp fragment of the 18S rRNA gene, revealed that the novel sequences of Hepatozoon spp. from our study were closely related to hemogregarine lineages found in lizards and snakes from Brazil, forming a well-supported monophyletic clade with them. The present study provides the first species description of Hepatoozon in D. corais and a new record of a host species for C. clelia using the integrated taxonomic data. We also highlight the importance of further investigations into the diversity of Hepatozoon in snakes, a rich but underestimated group of parasites, especially in the Amazonian biome. genetic morphological region mean dimensions 1425065 14 25 0 65 14.25±0.6 431043 4 31 43 4.31±0.4 μm vacuole sp nov 1341079 13 41 79 13.41±0.7 372035 3 72 35 3.72±0.3 other analyses 44 S gene spp Brazil wellsupported well supported them D C biome 142506 1 2 6 14.25±0. 43104 4.31±0. 134107 7 13.41±0. 37203 3.72±0. 14250 14.25±0 4310 4.31±0 13410 13.41±0 3720 3.72±0 1425 14.25± 431 4.31± 1341 13.41± 372 3.72± 142 14.25 4.31 134 13.41 37 3.72 14.2 4.3 13.4 3.7 14. 4. 13. 3.

https://doi.org/10.1590/0001-3765202320220115

Evaluation of pediatric diabetes mellitus after SARS-CoV-2 infection: A long-term prospective case series SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- infection longterm long term SARS-CoV
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Fink, Thais T.

; Canton, Ana P.M.

; Pereira, Maria Fernanda B.

; Bain, Vera

; Matsuo, Olívia

; Astley, Camilla

; Marques, Heloisa H.S.

; Correa-Silva, Simone

; Montenegro, Marilia M.

; Palmeira, Patricia

; Garanito, Marlene P.

; Duarte, Alberto J.S.

; Carneiro-Sampaio, Magda

; Latronico, Ana C.

; Silva, Clovis A.

Clinics

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2023, Volume 78 elocation 100299

Abstract: En | Text: En | PDF: En

https://doi.org/10.1016/j.clinsp.2023.100299

Primer registro de nematodos zoonóticos de transmisión alimentaria (Nematoda: Anisakidae) en músculo de Cynoscion guatucupa (pescadilla de calada) y Macrodon ancylodon (pescadilla de red) comercializado en Uruguay
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Crosi Martínez, Gonzalo

; García, Federico

; Viera, Gerardo

; Correa, Ivette

; Martínez, Valentina

; Pizzorno, Pablo

; Vidal, Gustavo

; Galli, Carina

; Trujillo, Lucía

; Díaz, Santiago

; Friss de Kereki, Cristina

; Dragonetti, José Pedro

; Armúa Fernánde, María Teresa

Revista FAVE. Sección Ciencias veterinarias

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jun 2022, Volume 21 N. 1 Pages 9 - 9

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract In the last 4 years, Uruguay has experienced a growing demand of raw fish-based foods, such as sushi, sahimi and ceviche. This scenario generated the need to assess the presence and concentration of zoonotic parasites (Nematodoes: Anisakidae) in edible parts of fish species traded in the local market. 233 fish specimens of 3 species commercialized in Uruguay were analyzed: Macrodon ancylodon, Micropogonias furnieri and Cynoscion guatucupa. The nematodes were quantified and identified at genus level, from coelomic cavity and muscle of the fishes, to finally stablish the ecological descriptors for each genus founded and for each fish species evaluated. Two of the three species of fish were parasitized with anisakids in both location (coelomic cavity and muscle), M. ancylodon and C. guatucupa. C. guatucupa was the most parasitized with a prevalence of 46%, while, the anisakid genus most prevalente was Contracaecum (prevalence of 35,1% in C. guatucupa and 32,4% in M. ancylodon). The finding of anisakids in M. ancylodon represents a report of a new host in Uruguay. Moreover, the finding for the first time in the country of these zoonotic parasites in edible parts of fish (muscle) is highlighted.

Resumen En los últimos 4 años, Uruguay ha experimentado una creciente demanda por el consumo de alimentos a base de pescado crudo, tales como sushi, sashimi y ceviche. Este escenario generó la necesidad de evaluar la presencia y concentración de parásitos zoonóticos (Nematoda: Anisakidae) en porciones comestibles de especies de pescado comercializadas en el mercado local. Se analizaron 233 ejemplares de tres especies de pescado comercializadas en Uruguay: Macrodon ancylodon, Micropogonias furnieri y Cynoscion guatucupa. Se cuantificaron e identificaron, a nivel de género, nematodos en cavidad celómica y músculo, estableciendo finalmente los descriptores ecológicos para cada género encontrado y para cada especie de pescado evaluada. Dos de las especies evaluadas se encontraban parasitadas a nivel de cavidad celómica y tejido muscular, M. ancylodon y C. guatucupa. Cynoscion guatucupa resultó la especie mayormente parasitada con una prevalencia de 46%, mientras que el género de anisákido más prevalente fue Contracaecum (prevalencia de 35,1% en C. guatucupa y 32,4% en M. ancylodon). El hallazgo de anisákidos en la especie M. ancylodon representa un nuevo registro de hospedador en Uruguay. Por otra parte, se reporta por primera vez en el país la presencia de estos parásitos zoonóticos en porciones comestibles (músculo).

https://doi.org/10.14409/favecv.2022.0.e0009

10.

Leaf extract of Coffea arabica L. reduces lipid peroxidation and has anti-platelet effect in a rat dyslipidemia model
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Simões, Mario Henrique Souza

; Salles, Bruno Cesar Correa

; Duarte, Stella Maris da Silveira

; Silva, Marcelo Aparecido da

; Viana, André Luiz Machado

; Moraes, Gabriel de Oliveira Isaac de

; Figueiredo, Sonia Aparecida

; Ferreira, Eric Batista

; Rodrigues, Maria Rita

; Paula, Fernanda Borges de Araújo

Brazilian Journal of Pharmaceutical Sciences

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2022, Volume 58 elocation e19562

Abstract: En | Text: En | PDF: En

Abstract This study aimed to evaluate the antioxidant potential of the Coffea arabica Lineu (L.) leaf extract and its effects on platelet aggregation of dyslipidemic rats. The extract was obtained by the percolation of C. arabica L. leaves in hydroethanolic solution 70% (v/v). The mass spectrometry FIA-ESI-MS² suggested the presence of chlorogenic acid, rutin acid, and quinic acid. The DPPH• radicals scavenging capacity was demonstrated (IC50 = 0.06 mg/mL). The extract was administered to rats by gavage (300 mg/kg/day) for 56 days. Dyslipidemia was induced by administering Triton WR-1339 (300 mg/kg body weight) on the 54th day. On day 56, blood was collected by puncturing the abdominal aorta artery and the aortic artery was removed. Lipid profile, markers of renal and hepatic injury, lipid peroxidation, and platelet aggregation tests were carried out. The ingestion of extract reduced the lipid peroxidation (aorta and plasma) and platelet aggregation in dyslipidemic rats. The extract did not affect markers of renal and hepatic function as analyzed in this study, suggesting neither impaired liver nor kidney function in these animals. Therefore, our results demonstrate that the extract of leaves of C. arabica L. show antioxidant potential in vitro and in vivo as well as anti-platelet aggregation in dyslipidemic animals.

https://doi.org/10.1590/s2175-97902022e19562

11.

Fatores associados ao desenvolvimento infantil em crianças brasileiras: linha de base da avaliação do impacto do Programa Criança Feliz
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Munhoz, Tiago N.

; Santos, Iná S.

; Blumenberg, Cauane

; Barcelos, Raquel Siqueira

; Bortolotto, Caroline C.

; Matijasevich, Alicia

; Santos Júnior, Hernane G.

; Santos, Letícia Marques dos

; Correa, Luciano L.

; Souza, Marta Rovery de

; Lira, Pedro I. C.

; Altafim, Elisa Rachel Pisani

; Macana, Esmeralda Correa

; Victora, Cesar G.

Cadernos de Saúde Pública

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2022, Volume 38 N. 2 elocation e00316920

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: O objetivo deste artigo foi avaliar os fatores socioeconômicos, familiares e individuais associados ao desenvolvimento infantil no primeiro ano de vida, entre famílias em vulnerabilidade social. Trata-se de uma análise transversal, com dados da linha de base de um ensaio randomizado. O estudo incluiu 3.242 crianças < 12 meses de idade, residentes em 30 municípios de cinco regiões do Brasil. A escolha de estados e municípios foi intencional, tendo como base a implementação do Programa Criança Feliz. A amostra foi selecionada a partir de crianças elegíveis para o Programa Criança Feliz, cujo objetivo é promover a estimulação e o desenvolvimento infantil. O Ages and Stages Questionnaire (ASQ) foi utilizado para avaliação do desenvolvimento infantil. Um modelo de análise multinível em três níveis (estado, município e indivíduos), usando teste de Wald para heterogeneidade e tendência linear, estimou a média do ASQ-3 e intervalo de 95% de confiança (IC95%). Análises foram ajustadas para potenciais confundidores. Foram analisadas informações de 3.061 (94,4%) crianças com dados disponíveis para ASQ-3. Escores de desenvolvimento infantil (total e em todos os domínios) foram cerca de 12% menores em crianças nascidas pré-termo e com restrição do crescimento intrauterino (pequenas para idade gestacional). Observou-se menores escores em filhos de mães com baixa escolaridade, com sintomas de depressão, com duas ou mais crianças menores de sete anos residindo no domicílio e que não relataram autopercepção de apoio/ajuda durante a gestação. Conclui-se que características potencialmente modificáveis (escolaridade, depressão materna e prematuridade/restrição do crescimento intrauterino) apresentaram maior impacto na redução do escore de desenvolvimento em todos os domínios avaliados.

Abstract: The study aimed to assess socioeconomic, family, and individual factors associated with infant development (i.e., in the first year of life) among families with social vulnerability. This was a cross-sectional analysis of baseline data from a randomized trial. The study included 3,242 children < 12 months of age living in 30 municipalities from five regions of Brazil. The choice of states and municipalities was intentional, based on the implementation of the Brazilian Happy Child Program. The sample was selected among eligible children for the Brazilian Happy Child Program, and the objective was the promotion of infant development. The Ages and Stages Questionnaire (ASQ) was used to assess infant development. A three-level analytical model (state, municipality, and individuals), using the Wald test for heterogeneity and linear trend, estimated the mean ASQ-3 and 95% confidence interval (95%CI). The analyses were adjusted for potential confounders. Information was analyzed for 3,061 (94.4%) children with available data for ASQ-3. Infant development scores (total and in all the domains) were some 12% lower in preterm children and those with intrauterine growth restriction (small for gestational age). Lower scores were seen in children of mothers with low schooling, depressive symptoms, two or more children under seven years of age living in the household, and who did not report self-perceived support or help during the pregnancy. In conclusion, potentially modifiable characteristics (schooling, maternal depression, and prematurity/intrauterine growth restriction) showed greater impact on reducing the infant development score in all the target domains.

Resumen: El objetivo fue evaluar los factores socioeconómicos, familiares e individuales, asociados al desarrollo infantil en el primer año de vida, entre familias con vulnerabilidad social. Se trata de un análisis transversal, con datos de la base de referencia de un ensayo aleatorio. El estudio incluyó a 3.242 niños < 12 meses de edad, residentes en 30 municipios de cinco regiones de Brasil. La elección de estados y municipios fue intencional, considerando como base la implementación del Programa Niño Feliz. La muestra se seleccionó a partir de niños elegibles para el Programa Niño Feliz, cuyo objetivo es promover la estimulación y el desarrollo infantil. Se utilizó el Ages and Stages Questionnaire (ASQ) para la evaluación del desarrollo infantil. Un modelo de análisis multinivel en tres niveles (estado, municipio e individuos), usando el test de Wald para la heterogeneidad y tendencia lineal, estimó la media del ASQ-3 y el intervalo de 95% de confianza (IC95%). Los análisis se ajustaron para potenciales factores de confusión. Se analizó información de 3.061 (94,4%) niños con datos disponibles para ASQ-3. Las puntuaciones de desarrollo infantil (total y en todos los dominios) fueron cerca de un 12% menores en niños nacidos pretérmino y con restricción del crecimiento intrauterino (pequeños para la edad gestacional). Se observaron menores puntuaciones en hijos de madres con baja escolaridad, con síntomas de depresión, con dos o más niños menores de siete años residiendo en el domicilio y que no informaron autopercepción de apoyo/ayuda durante la gestación. Se concluye que las características potencialmente modificables (escolaridad, depresión materna y prematuridad/restricción del crecimiento intrauterino) presentaron un mayor impacto en la reducción de la puntuación de desarrollo en todos los dominios evaluados.

https://doi.org/10.1590/0102-311x00316920

12.

Fatores associados ao desenvolvimento infantil em crianças brasileiras: linha de base da avaliação do impacto do Programa Criança Feliz
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Munhoz, Tiago N.

; Santos, Iná S.

; Blumenberg, Cauane

; Barcelos, Raquel Siqueira

; Bortolotto, Caroline C.

; Matijasevich, Alicia

; Santos Júnior, Hernane G.

; Santos, Letícia Marques dos

; Correa, Luciano L.

; Souza, Marta Rovery de

; Lira, Pedro I. C.

; Altafim, Elisa Rachel Pisani

; Macana, Esmeralda Correa

; Victora, Cesar G.

Cadernos de Saúde Pública

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2022, Volume 38 N. 2 elocation e00316920

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00316920

13.

Susceptibility of goats to poisoning by Tephrosia cinérea
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Brito Junior, João R.C.

; Soares, Yanca G.S.

; Nascimento, Maria Jussara R.

; Ferreira, Jefferson S.

; Alves, Rodrigo C.

; Dantas, Antônio F.M.

; Riet-Correa, Franklin

; Galiza, Glauco J.N.

Pesquisa Veterinária Brasileira

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2022, Volume 42 elocation e07047

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A intoxicação espontânea e experimental por Tephrosia cinerea no semiárido nordestino só foi descrita em ovinos. Patologicamente, tal intoxicação leva a ascite e fibrose hepática centrolobular. No entanto, esses efeitos requerem um estudo experimental em caprinos. Este estudo teve como objetivo determinar a suscetibilidade de caprinos à ingestão de T. cinerea e a dose tóxica mínima, descrevendo os principais achados clínicos e anatomopatológicos. A intoxicação foi reproduzida experimentalmente em um ovino que recebeu 10g/kg da planta moída e em dois caprinos, o primeiro recebendo a dose de 5g/kg e o segundo recebendo 10g/kg da planta moída. O ovino apresentou distensão abdominal 34 dias após o início da ingestão da planta, desenvolvendo decúbito esternal, dificuldade respiratória, opistótono, trismo mandibular, salivação, disfagia, vocalização e movimentos de pedalada no 50º dia do experimento. Foi observado acúmulo de líquido na cavidade abdominal e fígado via necropsia, com superfície capsular irregular e levemente esbranquiçada. Histologicamente, as principais lesões observadas no fígado foram fibrose moderada, distensão sinusoidal acentuada, acompanhada de hemorragia acentuada, por vezes formando pontes entre as regiões centrolobulares, associada à dissociação dos cordões de hepatócitos. Havia discretos astrócitos de Alzheimer tipo II na substância cinzenta na região do córtex occipital no sistema nervoso. A cabra 2 apresentou apatia, sonolência e perda de peso; no 62º dia, decúbito lateral evoluiu para decúbito esternal, com rotação do pescoço em direção ao flanco. Na necropsia, observou-se edema acentuado na face e barbela, e leve acúmulo de líquido; foi observado material levemente amarelado na cavidade abdominal. Havia áreas enegrecidas discretas na superfície capsular no fígado. Histologicamente, o fígado apresentava leve fibrose centrolobular associada à discreta dissociação dos cordões de hepatócitos e leve degeneração vacuolar do citoplasma dos hepatócitos. A cabra 1 não apresentou sinais clínicos; na necropsia, discretas áreas multifocais foram observadas no fígado na superfície capsular. Histologicamente, foi detectada degeneração vacuolar intracitoplasmática difusa dos hepatócitos. O quadro clínico e os achados anatomopatológicos diferem entre as espécies, comprovando a menor suscetibilidade dos caprinos à ingestão de Tephrosia cinerea (em relação aos ovinos), com diferenças na patogênese e aspectos epidemiológicos da intoxicação.

ABSTRACT: Spontaneous and experimental poisoning by Tephrosia cinerea in the northeastern semiarid region of Brazil has only been described in sheep. Pathologically, such poisoning leads to ascites and centrilobular liver fibrosis. However, these effects require an experimental study in goats. This study aimed to determine the goats’ susceptibility to the ingestion of T. cinerea and the minimum toxic dose, describing the main clinical and anatomopathological findings. Poisoning was reproduced experimentally in one sheep that received 10g/kg of the ground plant and in two goats, the first receiving a dose of 5g/kg and the second receiving 10g/kg of the ground plant. The sheep presented abdominal distension 34 days after beginning the ingestion of the plant, developing sternal decubitus, breathing difficulty, opisthotonos, mandibular trismus, salivation, dysphagia, vocalization, and pedaling movements on the 50th day of the experiment. Fluid accumulation was observed in the abdominal cavity and liver via necropsy, with an irregular, slightly whitish capsular surface. Histologically, the main lesions observed in the liver were moderate fibrosis, marked sinusoidal distension, accompanied by marked hemorrhage, sometimes forming bridges between the centrilobular regions, associated with a dissociation of hepatocyte cords. There were discrete Alzheimer’s type II astrocytes in the gray matter in the region of the occipital cortex in the nervous system. Goat 2 showed apathy, drowsiness, and weight loss; on the 62th day, lateral decubitus evolved to sternal decubitus, with a rotation of the neck towards the flank. At necropsy, marked edema was observed on the face and dewlap, and a slight accumulation of liquid; slightly yellowish material was observed in the abdominal cavity. There were discrete blackened areas on the capsular surface in the liver. Histologically, the liver showed mild centrilobular fibrosis associated with mild dissociation of hepatocyte cords and mild vacuolar degeneration of the hepatocyte cytoplasm. Goat 1 showed no clinical signs; at necropsy, discrete multifocal areas were observed in the liver on the capsular surface. Histologically, diffuse intracytoplasmic vacuolar degeneration of hepatocytes was detected. The clinical picture and anatomopathological findings differ between the species, proving the lower susceptibility of goats to Tephrosia cinerea ingestion (compared to sheep), with differences in the pathogenesis and epidemiological aspects of poisoning.

https://doi.org/10.1590/1678-5150-pvb-7047

14.

Salud vascular y pandemia: percepción del paciente en la consulta vascular ambulatoria durante COVID-19
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López-Uribe, Federico

; Luna, Hernán C.

; Contreras-Correa, Laura María

; Correa-Posada, Martha O.

; García-Vélez, John F.

Revista mexicana de angiología

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dec 2021, Volume 49 N. 4 Pages 107 - 112

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract Background: COVID-19 shifted the attention of the non-urgent disease, increasing the perception of deterioration in health, complaints for delays in patient care and dissatisfaction of the virtual consultation. Objective: To determine the patient's perception of the vascular health deterioration, and the fact of being subjected to telemedicine. Material and methods: Survey on 142 outpatient vascular surgery consultants between April and June 2021. Results: The majority had venous diseases (VD), the others were arterial diseases (AD and lymphatic diseases (LD). AD patients worsened symptoms during the pandemic; most of VD and LD patients remained the same; less than half of them were afraid of seeking in-person attention because of a possible COVID-19 infection, but they were rescheduled in a timely manner and were satisfied with the virtual consultation without changes in the overall perception of their vascular health. Conclusion: An increase in symptoms and a decrease on the opportunity for care were found, there was no significant impact on vascular health or complications.

Resumen Antecedentes: El COVID-19 desplazó la atención de las enfermedades no urgentes, aumentando la percepción del deterioro en salud, las quejas por demoras en la atención e insatisfacción con la consulta virtual. Objetivo: Determinar la percepción del paciente en la salud vascular y el uso de telemedicina durante la pandemia. Material y métodos: Encuesta en 142 pacientes de consulta de cirugía vascular entre abril y junio de 2021. Resultados: La mayoría tenía enfermedad venosa (EV) seguida de arterial (EA) y linfática (EL). Los pacientes con EA empeoraron los síntomas, mientras que los de EV o EL permanecieron igual. Menos de la mitad tuvo miedo a la atención médica presencial o la suspendieron voluntariamente por temor al contagio de COVID-19. Hubo reprogramación oportuna y satisfacción con la consulta virtual en la mayoría, sin repercusión en la percepción final del estado de salud vascular. Conclusión: Se encontró un aumento de síntomas y disminución en la oportunidad de atención, sin impacto significativo en la salud vascular o complicaciones.

https://doi.org/10.24875/rma.21000039 22 downloads

15.

Diretrizes da Sociedade Brasileira de Cardiologia sobre Angina Instável e Infarto Agudo do Miocárdio sem Supradesnível do Segmento ST – 2021
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Nicolau, José Carlos

; Feitosa Filho, Gilson Soares

; Petriz, João Luiz

; Furtado, Remo Holanda de Mendonça

; Précoma, Dalton Bertolim

; Lemke, Walmor

; Lopes, Renato Delascio

; Timerman, Ari

; Marin Neto, José A.

; Bezerra Neto, Luiz

; Gomes, Bruno Ferraz de Oliveira

; Santos, Eduardo Cavalcanti Lapa

; Piegas, Leopoldo Soares

; Soeiro, Alexandre de Matos

; Negri, Alexandre Jorge de Andrade

; Franci, Andre

; Markman Filho, Brivaldo

; Baccaro, Bruno Mendonça

; Montenegro, Carlos Eduardo Lucena

; Rochitte, Carlos Eduardo

; Barbosa, Carlos José Dornas Gonçalves

; Virgens, Cláudio Marcelo Bittencourt das

; Stefanini, Edson

; Manenti, Euler Roberto Fernandes

; Lima, Felipe Gallego

; Monteiro Júnior, Francisco das Chagas

; Correa Filho, Harry

; Pena, Henrique Patrus Mundim

; Pinto, Ibraim Masciarelli Francisco

; Falcão, João Luiz de Alencar Araripe

; Sena, Joberto Pinheiro

; Peixoto, José Maria

; Souza, Juliana Ascenção de

; Silva, Leonardo Sara da

; Maia, Lilia Nigro

; Ohe, Louis Nakayama

; Baracioli, Luciano Moreira

; Dallan, Luís Alberto de Oliveira

; Dallan, Luis Augusto Palma

; Mattos, Luiz Alberto Piva e

; Bodanese, Luiz Carlos

; Ritt, Luiz Eduardo Fonteles

; Canesin, Manoel Fernandes

; Rivas, Marcelo Bueno da Silva

; Franken, Marcelo

; Magalhães, Marcos José Gomes

; Oliveira Júnior, Múcio Tavares de

; Filgueiras Filho, Nivaldo Menezes

; Dutra, Oscar Pereira

; Coelho, Otávio Rizzi

; Leães, Paulo Ernesto

; Rossi, Paulo Roberto Ferreira

; Soares, Paulo Rogério

; Lemos Neto, Pedro Alves

; Farsky, Pedro Silvio

; Cavalcanti, Rafael Rebêlo C.

; Alves, Renato Jorge

; Kalil, Renato Abdala Karam

; Esporcatte, Roberto

; Marino, Roberto Luiz

; Giraldez, Roberto Rocha Corrêa Veiga

; Meneghelo, Romeu Sérgio

; Lima, Ronaldo de Souza Leão

; Ramos, Rui Fernando

; Falcão, Sandra Nivea dos Reis Saraiva

; Dalçóquio, Talia Falcão

; Lemke, Viviana de Mello Guzzo

; Chalela, William Azem

; Mathias Júnior, Wilson

Arquivos Brasileiros de Cardiologia

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jul 2021, Volume 117 N. 1 Pages 181 - 264

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20210180 3052 downloads

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