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RESUMO: O estudo foi realizado em um ovino, fêmea, de três anos de idade, da raça santa inês, procedente de uma propriedade localizada do município de Santo Antônio de Tauá, oeste do Pará. O animal acometido tinha histórico de exoftalmia no olho esquerdo, secreção nasal e dificuldade respiratória há mais de três meses. Ao exame físico o animal apresentava baixo escore corporal, apatia, assimetria facial unilateral, moderada exoftalmia unilateral esquerda, dispneia mista e exsudação nasal serossanguinolenta profusa unilateral. À necropsia, foi observada grande massa nasal, predominantemente branco-amarelada com áreas vermelho enegrecidas, de superfície irregular, finamente granular, úmida e friável. A massa invadia desde a junção mucocutânea do nariz esquerdo até as coanas, se infiltrava pelos seios nasais frontais, placa cribiforme e alcançava as meninges e a porção frontal do cérebro. À microscopia da superfície do epitélio nasal notou-se severa destruição dos cornetos e dos epitélios, evidenciada por extensas áreas de necrose com muitos debris celulares, ulceração e infecção bacteriana secundária. No sistema nervoso central (SNC) havia meningite piogranulomatosa com acentuada congestão de vasos, focos de necrose e inflamação granulomatosa. O diagnóstico de rinite granulomatosa de origem micótica associada ao fungo Conidiobolus lamprauges foi baseado nos achados da imuno-histoquímica. RESUMO ovino fêmea idade inês Tauá Pará meses corporal apatia esquerda necropsia brancoamarelada branco amarelada enegrecidas irregular granular friável coanas frontais cérebro notouse notou epitélios celulares secundária SNC (SNC vasos imunohistoquímica. imunohistoquímica imuno histoquímica. histoquímica imuno-histoquímica

ABSTRACT: The study was conducted on a 3-year-old female Santa Inês sheep from a property located in the municipality of Santo Antônio de Tauá, west of Pará. The affected animal had a history of exophthalmos in the left eye, nasal discharge, and breathing difficulty for more than three months. On physical examination, the animal had a low body score, apathy, unilateral facial asymmetry, moderate unilateral left exophthalmos, mixed dyspnea and unilateral profuse serosanguinous nasal discharge. At necropsy, a large nasal mass was observed, predominantly yellowish-white with blackish-red areas, with an irregular, finely granular, moist, and friable surface. The mass invaded from the mucocutaneous junction of the left nostril to the choanae, infiltrated the frontal sinuses, the cribiform plate, and reached the meninges and the frontal portion of the brain. Microscopy of the surface of the nasal epithelium showed severe destruction of the turbinates and epithelia, evidenced by extensive areas of necrosis with a large amount of cellular debris, ulceration, and secondary bacterial infection. In the central nervous system there was pyogranulomatous meningitis with marked vessel congestion, as well as foci of necrosis and granulomatous inflammation. Immunohistochemistry showed intense staining of numerous intralesional hyphae for antibodies against Conidiobolus lamprauges. The diagnosis of granulomatous rhinitis of mycotic origin associated with the Conidiobolus lamprauges was based on epidemiological, clinical-pathological, and immunohistochemical data. ABSTRACT 3yearold yearold 3 year old Tauá Pará eye discharge months examination score apathy asymmetry necropsy observed yellowishwhite yellowish white blackishred blackish red irregular granular moist choanae sinuses plate brain epithelia debris ulceration infection congestion inflammation epidemiological clinicalpathological, clinicalpathological clinical pathological, pathological clinical-pathological data

https://doi.org/10.1590/0103-8478cr20240016

Prevalence of lesions and oral mucosal normal variations in an elderly population in Costa Rica
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Fernández-Chaves, José Manuel

; Boza-Oreamuno, Yadira V.

; Masís-Monestel, Carlos

; Lau-Sánchez, Norma

Odovtos International Journal of Dental Sciences

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aug 2024, Volume 26 N. 2 Pages 113 - 127

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Establecer la prevalencia de lesiones de la mucosa oral y variaciones de lo normal en una población de adultos mayores. Estudio observacional en 156 participantes de Los Guido (San José, Costa Rica) del 2015 a 2016. Se evaluaron y analizaron de forma descriptiva y cualitativa información sociodemográfica, factores de riesgo, comorbilidad y exploración clínica. Los hallazgos en mucosa oral afectaron preferentemente a las mujeres (n=111; 71%), el rango de edad entre 60 y 69 años (n=65; 42%) y con el tabaco como factor de riesgo (n=67; 43%) e hipertensión arterial (n=101; 65%). Los hallazgos intraorales se presentaron preferentemente de forma conjunta variaciones de lo normal y patologías (n=71; 46%), predominantemente una variación de lo normal (n=67; 33%) y una patología (n=51; 43%). Las variaciones de lo normal más prevalentes fueron lengua saburral, várices linguales y amígdalas criptodónticas. Las enfermedades infecciosas (n=33; 21%), los desórdenes potencialmente malignos (n=30; 19 %) e injurias físicas y químicas (n=18; 12%) fueron los grupos más prevalentes. Las cuatro lesiones más predominantes fueron estomatitis protésica, queilitis actínica, queratosis friccional y glositis atrófica. No hubo diferencia estadísticamente significativa (p=0.392) al comparar la proporción de frecuencia por sexo. Las variaciones de la anatomía normal predominaron; siendo en forma individual la lengua saburral la más frecuente; de las patologías destacaron las enfermedades infecciosas principalmente la estomatitis protésica. Existe poca información en esta área en Costa Rica, es importante generar más estudios que permitan contribuir con la salud oral de la población adulta mayor.

Abstract To establish the prevalence of oral mucosal lesions and normal variations in a population of older adults. This observational study was conducted from 2015 to 2016 and involved 156 participants from Los Guido (San José, Costa Rica). The participants’ sociodemographic information, risk factors, comorbidity, and clinical examination were evaluated and analyzed descriptively and qualitatively. Findings in oral mucosa were found to preferentially affect women (n=111; 71%) and individuals between the ages of 60 and 69 years (n=65; 42%), having smoking as a risk factor (n=67; 43%), and suffering from arterial hypertension (n=101; 65%). Intraoral findings were mainly presented together with variations from normal and pathology (n=71; 46%), predominantly one variation from normal (n=67; 33%) and one pathology (n=51; 43%). The most prevalent normal variations were the saburral tongue, lingual varicose veins, and cryptic tonsils. Infectious diseases (n=33; 21%), potentially malignant disorders (n=30; 19%), and physical and chemical injuries (n=18; 12%) were the most prevalent groups. The four most predominant lesions were prosthetic stomatitis, actinic cheilitis, frictional keratosis, and atrophic glossitis. The differences in pathological groups were not statistically significant (p=0.392) when comparing the frequency ratio by sex. Variations of the normal anatomy are the predominant ones, the saburral tongue being the most prevalent individually; among the pathologies, the most remarkable group was the infectious diseases, and prosthetic stomatitis was the most frequent. The information about this subject in Costa Rica is limited. So it is important to conduct more studies that contribute to the oral health of the elderly population in this area.

https://doi.org/10.15517/ijds.2023.57081

Interactive Profile between 1,4-Naphthoquinone Derivatives and Human Serum Albumin 1,4Naphthoquinone 14Naphthoquinone Naphthoquinone 1,4 1 4 4Naphthoquinone 14 1,
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Ferreira, Romulo C.

; Chaves, Otávio Augusto

; Oliveira, Cosme Henrique C. S. de

; Ferreira, Vitor Francisco

; Ferreira, Sabrina B.

; Serpa, Carlos

; Cesarin-Sobrinho, Dari

; Netto-Ferreira, José Carlos

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 10 elocation e-20240043

Abstract: En | Text: En | PDF: En

The interactive profile between four 1,4-naphthoquinone derivatives (1-4) and human serum albumin (HSA) was studied by spectroscopic techniques and in silico calculations. The bimolecular quenching rate constant (kq ca. 1012 L mol-1 s-1) and the time-resolved fluorescence decays indicated a static fluorescence quenching mechanism. Thus, there is a spontaneous ground-state association, and based on both Stern-Volmer, modified Stern-Volmer, and van’t Hoff approaches, the association is moderate mainly driven by hydrophobic forces. The circular dichroism (CD) analysis indicated that until the proportion albumin:compound of 1:8 there is a weak perturbation on the structural content of albumin, while molecular docking results suggested subdomain IIA (site I), a positive electrostatic pocket, as the main binding site. Overall, even though the hydrogen atom replacement by methyl, fluorine, or chlorine atoms in the para position of the aromatic ring in the benzo[g]chromene-5,10-dione moiety changes the lipophilicity, it does not change the binding profile to HSA. 1,4naphthoquinone 14naphthoquinone naphthoquinone 1,4 1 4 14 (1-4 HSA (HSA calculations kq ca 101 mol1 mol mol- s1 s s-1 timeresolved time resolved mechanism Thus groundstate ground state SternVolmer, SternVolmer Stern Volmer, Volmer Stern-Volmer vant van t approaches forces CD (CD albumincompound compound 18 8 1: site I, I , I) pocket Overall methyl fluorine benzogchromene5,10dione benzogchromene510dione benzogchromenedione benzo g chromene 5,10 dione 5 10 lipophilicity 4naphthoquinone 1, (1- s- benzogchromene5 10dione benzogchromene 510 5,1 (1 51 5, (

https://doi.org/10.21577/0103-5053.20240043

Effect of Fiberglass Post Technique Removal on the Root Dentin Loss, the Root Canal Alignment and the Root Perforation Occurrence Loss
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Gomes, Marcio Alex Barros

; Moura, Camilla Christian Gomes

; Capeletti, Lucas Raineri

; Chaves, Gustavo Silva

; Decurcio, Daniel de Almeida

; Rodrigues, Monise de Paula

; Soares, Carlos José

Brazilian Dental Journal

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2024, Volume 35 elocation e23-5851

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O retratamento do canal radicular e a fratura de pinos de fibra de vidro (FGP) podem exigir a remoção de FGPs. O objetivo deste estudo foi avaliar a influência das técnicas de remoção de FGP no tempo de remoção de FGP (min), no volume de dentina radicular removida (mm3), na alteração do ângulo do alinhamento do canal radicular (o) e na ocorrência de perfuração radicular usando análise de tomografia computadorizada de feixe cônico (CBCT). Trinta molares superiores extraídos foram divididos aleatoriamente em 3 grupos: Mic-Ult, FGP removido usando insertos ultrassônicos sob ampliação microscópica; Mic-DiB, FGP removido usando pontas de diamante sob ampliação microscópica, e Endo-G, FGP removido usando guia prototipado. Os CBCTs foram feitos após a abertura do acesso e após a remoção do FGP. O volume de dentina radicular, o alinhamento do canal radicular e a perfuração radicular foram realizados com os softwares InVesalius e Mimics. A alteração do ângulo do canal radicular após a remoção do FGP foi realizada usando o software ImageJ. O tempo para remoção do FGP foi calculado em min. Os dados foram analisados por análise de variância unidirecional seguida pelo teste Tukey HSD (α = 0,05). Endo-G resultou em significativamente menor remoção de dentina radicular (p< 0,001) e significativamente menor tempo para o procedimento do que Mic-Ult e Mic-DiB (p< 0,001). Mic-DiB resultou em 1 e Mic-Ult em 2 perfurações de dentina radicular. A remoção do pino FGP usando Mic-Ult e Mic-DiB exibiu alteração significativamente maior no alinhamento do canal radicular do que usando Endo-G (p<0,001). A remoção de FGP usando Endo-G resultou em maior preservação do alinhamento do canal original, preservou a estrutura da dentina radicular e exigiu menor tempo em comparação com a remoção de FGP usando Mic-DiB ou Mic-Ult sob ampliação microscópica. (FGP FGPs min, min , (min) mm3, mm3 mm (mm3) (o CBCT. CBCT . (CBCT) grupos MicUlt, MicUlt Mic Ult, Ult microscópica MicDiB, MicDiB DiB, DiB EndoG, EndoG Endo G, G prototipado Mimics ImageJ α 0,05. 005 0,05 0 05 0,05) p< p (p 0,001 0001 001 0,001. p<0,001. p0001 p<0,001 (p<0,001) original (min (mm3 (CBCT 00 0,0 0,00 000 p000 p<0,00 (p<0,001 (mm 0, p00 p<0,0 (p<0,00 p0 p<0, (p<0,0 p<0 (p<0, (p<0

Abstract Root canal retreatment and fracture of fiberglass posts (FGP) can require the FGP removal. The aim of this study was to evaluate the effect of the FGP removal protocol on the time for FGP removal (min), the root dentin removed (mm3), the angle alteration of the root canal alignment (o), and the root perforation occurrence using cone-beam computed tomography (CBCT) analysis. Thirty extracted maxillary molars were randomly assigned to 3 groups (n = 10): Mic-Ult, FGP removed using ultrasonic inserts under microscopic magnification; Mic-DiB, FGP removed using diamond burs under microscopic magnification, and Endo-G, FGP removed using Endo-G. CBCTs were made after access opening and after FGP removal. The volume of root dentin, the root canal alignment and root perforation were performed using InVesalius and Mimics softwares. Root canal angle alteration after FGP removal was performed using ImageJ software. The time for FGP removal was calculated in min. Data were analysed by one-way analysis of variance was followed by Tukey HSD test (α = 0.05). Endo-G resulted in significantly lower root dentin removal (p< .001), and significantly less time than Mic-Ult and Mic-DiB (p< .001). Mic-DiB had 1 and Mic-Ult had 2 root dentin perforations. FGP post removal using Mic-Ult and Mic-DiB exhibited significantly greater alteration in the root canal alignment than that using Endo-G (p< .001). FGP removal using Endo-G exhibited better preservation of the original canal alignment, saved root dentin structure, and also required less time compared to FGP post removal using Mic-DiB or Mic-Ult under microscopic magnification. (FGP min, min , (min) mm3, mm3 mm (mm3) o, o (o) conebeam cone beam CBCT (CBCT n 10 10) MicUlt, MicUlt Mic Ult, Ult magnification MicDiB, MicDiB DiB, DiB EndoG, EndoG Endo G, G EndoG. G. softwares software oneway one way α 0.05. 005 0.05 . 0 05 0.05) p< p (p .001, 001 .001 .001) .001. perforations structure (min (mm3 (o 00 0.0 .00 (mm 0. .0

https://doi.org/10.1590/0103-644020235851

INTERVERTEBRAL FORAMEN ANATOMY OF THE LUMBAR SPINE: AN OVERVIEW SPINE
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BERGAMASCHI, JOãO PAULO MACHADO

; CHAVES, BERNARDO JOSé MOREIRA

; CAMPOS, CARLOS ANDRé ROCHA

; FONSECA, MARCELO GIACOMIN DA

; MORALE, VICTOR

; TIRAPELLI, LUíS FERNANDO

; WIRTH, FERNANDA

Coluna/Columna

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2024, Volume 23 N. 4 elocation e291413

Abstract: En Es Pt | Text: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT In recent decades, minimally invasive endoscopic spine surgeries have advanced significantly, enabling effective interventions with reduced patient trauma. The lumbar transforaminal approach, which utilizes Kambin’s triangle as an anatomical reference, stands out for its clinical relevance. This article reviews the anatomy of the lumbar intervertebral foramen, emphasizing crucial anatomical variations for the safety and efficacy of the transforaminal approach in endoscopic spine surgeries. Detailed knowledge of foraminal anatomy and adjacent structures is essential for surgical planning, allowing safe access and minimizing neurological complications. Level of Evidence IV; Case Report. decades significantly trauma Kambins Kambin s reference relevance foramen planning complications IV Report

RESUMEN En las últimas décadas, las cirugías endoscópicas mínimamente invasivas de la columna vertebral han avanzado significativamente, permitiendo intervenciones efectivas con menor trauma al paciente. El abordaje transforaminal lumbar, que utiliza el triángulo de Kambin como referencia anatómica, se destaca por su relevancia clínica. Este artículo revisa la anatomía del foramen intervertebral lumbar, enfatizando variaciones anatómicas cruciales para la seguridad y eficacia del abordaje transforaminal en cirugías endoscópicas de la columna vertebral. El conocimiento detallado de la anatomía foraminal y de las estructuras adyacentes es esencial para la planificación quirúrgica, permitiendo un acceso seguro y minimizando complicaciones neurológicas. Nivel de Evidencia IV; Reporte de Caso. décadas significativamente paciente lumbar anatómica clínica quirúrgica neurológicas IV Caso

RESUMO Nas últimas décadas, as cirurgias endoscópicas minimamente invasivas da coluna vertebral avançaram significativamente, permitindo intervenções eficazes com menor trauma ao paciente. A abordagem transforaminal lombar, que utiliza o triângulo de Kambin como referência anatômica, destaca-se pela sua relevância clínica. Este artigo revisa a anatomia do forame intervertebral lombar, enfatizando variações anatômicas cruciais para a segurança e eficácia da abordagem transforaminal em cirurgias endoscópicas da coluna. O conhecimento detalhado da anatomia foraminal e das estruturas adjacentes é essencial para o planejamento cirúrgico, permitindo acesso seguro e minimizando complicações neurológicas. Nível de Evidência IV; Relato de Caso. décadas significativamente paciente lombar anatômica destacase destaca se clínica cirúrgico neurológicas IV Caso

https://doi.org/10.1590/s1808-185120242304291413

Fluoride-modified implant surfaces improves osseointegration in the tibias of rats with induced diabetes Fluoridemodified Fluoride modified
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Oliveira, Guilherme José Pimentel Lopes de

; Fontanari, Lucas Amaral

; Souza, João Antônio Chaves de

; Spin-Neto, Rubens

; Elias, Carlos Nelson

; Marcantonio Junior, Elcio

; Orrico, Silvana Regina Perez

Brazilian Dental Journal

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oct 2023, Volume 34 N. 5 Pages 43 - 52

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Este estudo avaliou a influência de uma superfície de titânio modificada com flúor na osseointegração em ratos com diabetes induzida. Cento e oitenta ratos foram distribuídos aleatoriamente em 3 grupos com 60 animais cada: Grupo controle (C): Animais sem diabetes; Grupo Diabetes (D): Animais com diabetes induzida descompensada; Grupo Diabetes Controlado (CD): Animais com diabetes induzido controlado pela administração de insulina. O diabetes foi induzido por injeção de estreptozotocina. Cada animal recebeu 2 implantes na metáfise proximal da tíbia, um com superfície usinada (M) e outro com superfície de titânio modificado com flúor (F), após 4 semanas de indução do diabetes. Os animais foram submetidos à eutanásia 2, 4 e 6 semanas após a colocação do implante (n = 20 animais/grupo). A osseointegração foi avaliada pelo teste de torque de remoção do implante e pela análise histométrica dos cortes histológicos não descalcificados: 1) Contato osso-implante (%BIC); 2) Área de tecido ósseo entre as roscas do implante (%BBT). Os implantes com superfície F apresentaram maior torque de remoção do que os implantes com superfície M em todos os grupos. Não houve diferença no %BIC entre os grupos independente da superfície utilizada. A superfície F mostrou tendência a apresentar maiores valores de %BBT para os 3 períodos de avaliação no grupo D. As superfícies de implantes modificadas com flúor não influenciaram nos dados de %BIC e %BBT. Entretanto, essas superfícies aumentaram o travamento dos implantes no tecido ósseo. A hiperglicemia foi associada a menores torques de remoção dos implantes independentemente do tipo de superfície de implante utilizada. cada C (C) D (D) descompensada CD (CD) insulina estreptozotocina tíbia (M F, , (F) n animais/grupo. animaisgrupo animais/grupo . animais/grupo) descalcificados 1 ossoimplante osso BIC (%BIC) BBT (%BBT) utilizada Entretanto (C (D (CD (F (%BIC (%BBT

Abstract This study evaluated the influence of a fluoride-modified titanium surface on osseointegration in rats with induced diabetes. One hundred and eighty rats were randomly allocated into 3 groups with 60 animals each: Control group (C): Animals without diabetes; Diabetes Group (D): Animals with uncontrolled induced diabetes; Controlled Diabetes Group (CD): Animals with diabetes induced controlled by the insulin administration. Diabetes was induced by streptozotocin injection. Each animal received 2 implants in the proximal tibial metaphysis, one with the machined surface (M) and the other one with a fluoride-modified titanium surface (F), after 4 weeks of induction of diabetes. The animals were submitted to euthanasia 2, 4, and 6 weeks after the implant placement (n = 20 animals/group). The osseointegration was evaluated by the implant removal torque test and the histometric analysis of the non-decalcified histological sections: 1) Contact bone/implant (%BIC); 2) Bone tissue area between implant threads (%BBT). Implants with F surface showed a higher removal torque than implants with surface M in all groups. There was no difference in %BIC between the groups regardless of the surface used. The F surface showed a tendency to present higher %BBT values for the 3 evaluation periods in the D group. The fluoride-modified implant surface has no impact on the %BIC and %BBT. However, the fluoride-modified implant surface increases the locking of the implants with the bone. The hyperglycemia was associated with lower removal torque values despite the surfaces of the implant used. fluoridemodified fluoride modified each C (C) (D) CD (CD) administration injection metaphysis (M F, , (F) n animals/group. animalsgroup animals/group . animals/group) nondecalcified non decalcified sections 1 boneimplant bone BIC (%BIC) BBT (%BBT) used However (C (D (CD (F (%BIC (%BBT

https://doi.org/10.1590/0103-6440202305439

Análise de particularidades da participação lusófona em uma Rede de Conhecimentos em Enfermagem
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Zanchetta, Margareth Santos

; Medeiros, Marcelo

; Carvalho, José Carlos Marques de

; Baixinho, Cristina Rosa Soares Lavareda

; Primo, Cândida Caniçali

; Chaves, Manuel Carlos Rodrigues Fernandes

; Gouveia, Márcia Teles de Oliveira

; Girardon-Perlini, Nara Marilene Oliveira

; Rocha, Cristianne Maria Famer

; Costa, Edwaldo

; Santos, Walterlânia Silva

; Pessoa, Vera Lúcia Mendes de Paula

Escola Anna Nery

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2023, Volume 27 elocation e20220194

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo Objetivo Descrever o exercício conceitual de reflexão sobre as possibilidades e particularidades da participação das Escolas de Enfermagem e Faculdades de Enfermagem lusófonas na Rede de Conhecimentos em Enfermagem. Método Análise das informações obtidas em um levantamento de recursos institucionais de acordo com o marco conceitual proposto por Prug e Prusak sobre rede de conhecimentos. A ponderação de aspectos positivos e negativos - analisando o aprendizado com as informações - levou em consideração as possíveis soluções para um plano de ação. Resultados Tanto nas ações institucionais para suportar a pesquisa em Enfermagem como nos benefícios almejados com a participação na Rede existe o interesse na internacionalização da pesquisa e no trabalho colaborativo. Com a ampliação dos horizontes da ciência da Enfermagem lusófona, este trabalho visa aumentar o impacto da pesquisa e agilizar a divulgação e a utilização dos resultados, tanto na educação como na clínica. Conclusão e Implicações para a prática A participação das referidas instituições oferece inúmeras possibilidades de demonstrar originalidade, criatividade e perícia de sua prática docente e de pesquisa, favorecendo o compartilhamento de ideias e práticas. A prática de produção científica, por docentes e discentes, pode ser aprimorada pelo refinamento de modos de pensar, criar, produzir e disseminar. conhecimentos ação colaborativo lusófona resultados clínica originalidade práticas científica discentes pensar criar disseminar

Abstract Objective To describe the conceptual exercise of reflecting on the possibilities and particularities of the participation of Lusophone schools of nursing in the Nursing Knowledge Network. Method An analysis was conducted using information obtained from an environmental scan of institutional resources following the conceptual framework by Prug and Prusak on the knowledge networks. The learnings reported in the analysis are based on the collected information and reflections on the positive and negative aspects of participation, while proposing possible solutions for an action plan. Results There is interest in the internationalization of research and collaborative work both as institutional actions to support nursing research and potential benefits due to participation in the Network. The collaborative work has potential to increase the impact of research, expedite dissemination and use of results both in education and in clinical practice, broadening the horizons of Lusophone nursing science. Conclusion and Implications for practice Participation of these institutions in the Network offers numerous possibilities to demonstrate the originality, creativity and expertise of their teaching and research practice, encouraging the sharing of ideas and practices. The practice of scientific production in all its scenarios by educators and students can be improved through refined ways of thinking, creating, producing, and disseminating knowledge. networks plan science originality practices thinking creating producing

Resumen Objetivo Describir el ejercicio conceptual de reflexión de las posibilidades y particularidades de la participación de facultades de Enfermería de lengua portuguesa en la Red de Conocimientos de Enfermería. Método Análisis de datos obtenidos de un sondeo de recursos institucionales bajo el marco conceptual de Prug y Prusak sobre la red de conocimiento. El planteamiento de aspectos positivos y negativos del aprendizaje abarcó soluciones para elaborar un plan de acción. Resultados En las acciones institucionales de apoyo a la investigación en Enfermería y los beneficios aspirados con la participación en la Red, existe un interés por la internacionalización de la investigación y el trabajo colaborativo –que tiene como objetivo aumentar el impacto de la investigación, estimular la divulgación y el aprovechamiento de los resultados en la enseñanza y la clínica, con la ampliación de los horizontes de la Enfermería de instituciones de habla portuguesa. Conclusión e Implicaciones en la práctica La Red ofrece numerosas posibilidades para las instituciones participantes respecto a la demostración de originalidad, creatividad y experiencia en la práctica docente y de investigación, fomentando el intercambio de ideas y prácticas. La práctica de la producción científica por profesores y estudiantes puede verse mejorada por la reflexión, creación, producción y difusión de conocimientos. conocimiento acción que clínica originalidad prácticas creación conocimientos

https://doi.org/10.1590/2177-9465-ean-2022-0194pt

Profilaxis para sangrado gastrointestinal en pacientes del servicio de medicina interna de un hospital universitario
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Diaztagle-Fernández, Juan José

; Sprockel-Díaz, John Jaime

; Mojica-Corzo, Ezequiel Masdeeiner

; Vásquez-Hoyos, Leonidas

; Cruz-Buitrago, Roberto Hernando

; Eslava-Orozco, David Felipe

; Hernández-Aguirre, Andrés Camilo

; Navarro-Noguera, Juan Carlos

; Chaves-Santiago, Walter Gabriel

Universidad y Salud

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dec 2022, Volume 24 N. 3 Pages 273 - 278

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen Introducción: Los medicamentos antiulcerosos son utilizados frecuentemente en pacientes hospitalizados, sin embargo, a menudo este uso no está indicado. Objetivo: Describir la frecuencia de prescripción e indicación de medicamentos para prevenir el sangrado gastrointestinal en pacientes hospitalizados. Materiales y métodos: Estudio de corte trasversal, descriptivo, prospectivo del servicio de Medicina Interna de la Sociedad de Cirugía de Bogotá- Hospital de San José de Bogotá, Colombia. Se excluyeron pacientes con diagnóstico de sangrado gastrointestinal o antecedente de alergia a los medicamentos antiulcerosos. Se recolectaron datos demográficos, así como fármacos prescritos. Se determinó si la indicación del fármaco era adecuada y se identificó el tipo de error de prescripción. Resultados: Se incluyeron 179 pacientes, 102 (57%) mujeres. Promedio de edad de 61,3 años (±20,2). El principal diagnóstico de ingreso fue enfermedad infecciosa 76 (42,4%). Del total de pacientes, 165 (92,17%) recibieron medicamento para prevención del sangrado gastrointestinal. La indicación fue adecuada en 75 pacientes (41,89%). El error más frecuente fue el uso en pacientes de bajo riesgo de sangrado, 101 (97,1%). Conclusión: Un alto porcentaje de los pacientes recibió medicación para la prevención del sangrado gastrointestinal. En aproximadamente la mitad de estos no estaba indicada.

Abstract Introduction: Anti-ulcer medications are frequently used in hospitalized patients, yet their use is not usually indicated. Objective: To describe the frequency of prescription and indication of medications to prevent gastrointestinal bleeding in hospitalized patients. Materials and methods: A cross-sectional, descriptive, prospective study was carried out in the Internal Medicine service of the Surgery Society of Bogota-San Jose Hospital of Bogota (Colombia). Excluded patients were those with either a gastrointestinal bleeding diagnosis or a history of allergy to anti-ulcer medications. Demographic data and information regarding prescribed medications were collected. It was determined whether the medicine indication was adequate and the type of prescription error was identified. Results: 179 patients were included in the study, 57% (102) of which were women. The average age was 61.3 (±20.2) years old. Infectious disease was the main admission diagnosis (76; 42.4%). A 92.17% (165) of the total number of patients received medications to prevent gastrointestinal bleeding. This indication was adequate for 75 (41.89%) patients. The most frequent error was their use in bleeding low-risk patients (101; 97.1%). Conclusion: A high percentage of patients received medication to prevent gastrointestinal bleeding. However, in about half of these patients it was not indicated.

https://doi.org/10.22267/rus.222403.282 69 downloads

Recomendaciones en el abordaje del hematoma intracerebral espontáneo durante la internación
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Pigretti, Santiago G.

; Mirofsky, Matías

; García, Darío E.

; Issac, Cristian

; Valdez, Pascual

; Persi, Gabriel G.

; Mamani, Carlos E.

; Guyon, Jorgelina

; Álvarez, Héctor

; Montes, Mariana

; Daza Aramayo, José M.

; Iturrieta, Pablo

; Chaves, Hernán

; Sarmiento, Verónica

; Tumino, Leandro

; Domeniconi, Gustavo

; Castagna, Rosa

; Sabio, Rodrigo

; Videtta, Walter

; Ciarrocchi, Nicolás

; Lerman, Damián

; Dossi, Daiana E.

; Balian, Natalia R.

; Velasquez, Mariela A.

; Rufino Saravia, Gonzalo

; Alet, Matías J.

; Rodríguez Lucci, Federico

; Ciardi, Celina

; Pujol Lereis, Virginia

; Claverie, Santiago

; Casanova, Matías

; González, Leonardo

; Mónaco, Juan Manuel

; Cárdenas, Rolando E.

; Cirio, Juan José

; Arturi, Jessica

; Requejo, Flavio

; Plou, Pedro L.

; Orzuza, Gabriela

; Bonardo, Pablo

; Díaz, María Fernanda

; Payaslian, Silvio

; Andrade, María Gabriela

; Gomez Schneider, Maia M.

; Romano, Marina

; Colla Machado, Pedro

; Arroyo, José

; Arcondo, María Florencia

; Svampa, Silvana

; Armenteros, Cristhian

; Tejada Jacob, Virginia

; Zurrú, María Cristina

Medicina (Buenos Aires)

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nov 2022, Volume 82 Suppl. 4 Pages 1 - 56

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen El accidente cerebrovascular (ACV) constituye la principal causa de discapacidad de origen neuro- lógico en los adultos mayores a 40 años y la cuarta causa de muerte en Argentina. En los últimos diez años las publicaciones indexadas relacionadas al tratamiento del ACV isquémico fueron más numerosas que las de ACV hemorrágico. El objetivo de este material es proporcionar recomendaciones locales y actualiza- das del abordaje de pacientes con hematoma intraparenquimatoso espontáneo durante la internación. Para la redacción de este manuscrito se convocó a especialistas en esta enfermedad que conformaron grupos de trabajo. Se plantearon 10 tópicos centrales expresados como epidemiologia, atención inicial, imágenes, tratamiento de la presión arterial, reversión de antitrombóticos, indicación de cirugía, profilaxis anticonvulsivante, pronóstico, prevención de complicaciones y reinicio de antitrombóticos. De cada tópico se plantearon mediante preguntas PICO los interrogantes más frecuentes de la práctica diaria. Luego de una revisión sistemática de la literatura, se generaron recomendaciones evaluadas mediante sistema GRADE y consensuadas entre autores y pacientes.

Abstract Stroke is the leading cause of neurological disability in people over 40 years of age and the fourth leading cause of death in Argentina. In the last ten years, the indexed publications related to the treatment of ischemic stroke were more numerous than those of hemorrhagic stroke. The objective of this material is to provide local and updated recommendations for the management of patients with spontaneous intracere- bral hemorrhage during hospitalization. For the writing of this manuscript, diferent specialists were convened to form working groups. Ten central topics expressed as epidemiology, initial care, imaging, blood pressure treatment, reversal of antithrombotics, indication for surgery, seizure prophylaxis, prognosis, prevention of complications and resumption of antithrombotics were raised. For each topic, the most frequent questions of daily practice were raised through PICO questions. After a systematic review of the literature, recommendations were generated, evaluated using the GRADE system and agreed between authors and patients.

10.

Guía de práctica clínica para el manejo de la neumonía adquirida en la comunidad
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Cortés, Jorge Alberto

; Cuervo-Maldonado, Sonia Isabel

; Nocua-Báez, Laura Cristina

; Valderrama, Martha Carolina

; Sánchez, Edgar Alberto

; Saavedra, Alfredo

; Torres, July Vianneth

; Forero, Diana Paola

; Álvarez-Moreno, Carlos Arturo

; Leal, Aura Lucía

; Pérez, Jairo Enrique

; Rodríguez, Iván Arturo

; Guevara, Fredy Orlando

; Saavedra, Carlos Humberto

; Vergara, Erika Paola

; Montúfar, Franco Eduardo

; Espinosa, Tatiana

; Chaves, Walter

; Carrizosa, Jorge Armando

; Meléndez, Sugeich Del Mar

; Espinosa, Carmelo José

; García, Felipe

; Guzmán, Ingrid Jany

; Cortés, Sergio Leonardo

; Díaz, Jorge Augusto

; González, Nathaly

Revista de la Facultad de Medicina

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jun 2022, Volume 70 N. 2 elocation e93814

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

Resumen La neumonía sigue siendo una de las principales causas de consulta y de hospitalización a la que, además de su un alto impacto en términos de morbilidad y mortalidad, se suma la actual problemática de resistencia a los antimicrobianos, por lo que establecer directrices que permitan su adecuado diagnóstico y tratamiento es de gran importancia para obtener mejores desenlaces clínicos y promover un uso racional de antibióticos en estos pacientes. La presente guía de práctica clínica (GPC) contiene recomendaciones basadas en la evidencia para el diagnóstico y tratamiento de la neumonía adquirida en la comunidad en adultos, las cuales fueron realizadas mediante el proceso de adaptación de GPC basadas en la evidencia para el contexto colombiano.

Abstract Pneumonia continues to be one of the main causes of consultation and hospitalization to which, besides its high impact on morbidity and mortality, the current problem of antimicrobial resistance is added; thus, establishing guidelines that allow its adequate diagnosis and treatment is of great importance to obtain better clinical outcomes and promote a rational use of antibiotics in these patients. This clinical practice guideline (CPG) contains evidence-based recommendations for the diagnosis and treatment of community-acquired pneumonia in adult population; these recommendations were made by means of the process of adaptation of evidence-based CPGs for the Colombian context.

https://doi.org/10.15446/revfacmed.v70n2.93814.

11.

Biochemical profile of castrated and uncastrated male goats supplemented with vitamin E or not
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Pereira, Anderson Lopes

; Brito, Danilo Rodrigues Barros

; Cutrim Júnior, José Antônio Alves

; Castro, Lucimeire Amorim

; Silva, Igor Cassiano Saraiva

; Chaves, Daniel Praseres

; Silva Neto, Carlos Nunes da

Revista Brasileira de Saúde e Produção Animal

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2022, Volume 23 elocation e21472022

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivou-se avaliar os parâmetros bioquímicos de caprinos submetidos ou não a castração e recebendo ou não suplementação com vitamina E. Um total de 24 caprinos, machos não castrados (12 unidades experimentais) e machos castrados (12 unidades experimentais), com peso corporal médio de 17,6 kg ± 2,67 kg, foram distribuídos em delineamento inteiramente casualizado em arranjo fatorial 2 x 2, sendo duas condições animais (macho castrado e não castrado) e suplementação com vitamina E (com e sem suplementação), com seis repetições. Houve efeito dos tratamentos (P<0,05) ao longo do tempo para todas as variáveis estudadas. Houve efeito da suplementação vitamínica (P<0,05) para fósforo, ferro, proteína, glicose, aspartato aminotransferase (AST), alanina aminotransferase (ALP) e gama-glutamiltransferase (GGT). A suplementação vitamínica elevou os níveis de glicose, creatinina e GTT ao longo do tempo, e reduziu os níveis de fósforo, ferro, proteína, albumina, AST e ALP. Concluímos que a vitamina E influenciou nos parâmetros bioquímicos estudados, porém a castração não alterou o perfil bioquímico de caprinos, independentemente de estarem suplementados ou não com a vitamina E.

ABSTRACT The objective of this study was to evaluate the biochemical parameters of goats submitted to castration or not and receiving supplementation with vitamin E or not. A total of 24 goats, uncastrated (12 experimental units) and castrated males (12 experimental units), with average body weight weighing 17.6 kg ± 2.67 kg, were distributed in a completely randomized design in a 2 x 2 factorial arrangement, with two animal conditions (castrated and uncastrated male) and vitamin E supplementation (with and without supplementation), with six replications. There was an effect of treatments (P<0.05) over time for all studied variables. There was an effect of vitamin supplementation (P<0.05) for phosphorus, iron, protein, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALP) and gamma-glutamyltransferase (GGT). Vitamin supplementation increased glucose, creatinine and GTT levels over time, and reduced levels of phosphorus, iron, protein, albumin, AST and ALP. We conclude that vitamin E influenced the biochemical parameters studied, but castration did not change the biochemical profile of goats, regardless of whether they were supplemented with vitamin E or not.

https://doi.org/10.1590/s1519-994021472022

12.

Brazilian guidelines for the treatment of outpatients with suspected or confirmed COVID-19. A joint guideline of the Brazilian Association of Emergency Medicine (ABRAMEDE), Brazilian Medical Association (AMB), Brazilian Society of Angiology and Vascular Surgery (SBACV), Brazilian Society of Geriatrics and Gerontology (SBGG), Brazilian Society of Infectious Diseases (SBI), Brazilian Society of Family and Community Medicine (SBFMC), and Brazilian Thoracic Society (SBPT)
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Falavigna, Maicon

; Belli, Karlyse Claudino

; Barbosa, Alexandre Naime

; Zavascki, Alexandre Prehn

; Nastri, Ana Catharina de Seixas Santos

; Santana, Christiane Machado

; Stein, Cinara

; Gräf, Débora Dalmas

; Cadegiani, Flavio Adsuara

; Guimarães, Hélio Penna

; Monteiro, José Tadeu

; Ferreira, Juliana Carvalho

; de Azevedo, Luciano Cesar Pontes

; Magri, Marcelo Mihailenko Chaves

; Sobreira, Marcone Lima

; Dias, Maria Beatriz Gandra de Souza

; de Oliveira, Maura Salaroli

; Corradi, Mirian de Freitas Dal Ben

; Rosa, Regis

; Heinzelmann, Ricardo Souza

; da Silva, Rosemeri Maurici

; Belfort Junior, Rubens

; Cimerman, Sergio

; Colpani, Verônica

; Veiga, Viviane Cordeiro

; de Carvalho, Carlos Roberto Ribeiro

Brazilian Journal of Infectious Diseases

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2022, Volume 26 N. 2 elocation 102347

Abstract: En | Text: En | PDF: En

ABSTRACT Background Several therapies have been used or proposed for the treatment of COVID-19, although their effectiveness and safety have not been properly evaluated. The purpose of this document is to provide recommendations to support decisions about the drug treatment of outpatients with COVID-19 in Brazil. Methods A panel consisting of experts from different clinical fields, representatives of the Brazilian Ministry of Health, and methodologists (37 members in total) was responsible for preparing these guidelines. A rapid guideline development method was used, based on the adoption and/or adaptation of recommendations from existing international guidelines combined with additional structured searches for primary studies and new recommendations whenever necessary (GRADE-ADOLOPMENT). The rating of quality of evidence and the drafting of recommendations followed the GRADE method. Results Ten technologies were evaluated, and 10 recommendations were prepared. Recommendations were made against the use of anticoagulants, azithromycin, budesonide, colchicine, corticosteroids, hydroxychloroquine/chloroquine alone or combined with azithromycin, ivermectin, nitazoxanide, and convalescent plasma. It was not possible to make a recommendation regarding the use of monoclonal antibodies in outpatients, as their benefit is uncertain and their cost is high, with limitations of availability and implementation. Conclusion To date, few therapies have demonstrated effectiveness in the treatment of outpatients with COVID-19. Recommendations are restricted to what should not be used, in order to provide the best treatment according to the principles of evidence-based medicine and to promote resource savings by aboiding ineffective treatments.

https://doi.org/10.1016/j.bjid.2022.102347

13.

Brazilian Thoracic Association Consensus on Sleep-disordered Breathing
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Duarte, Ricardo Luiz de Menezes

; Togeiro, Sonia Maria Guimarães Pereira

; Palombini, Luciana de Oliveira

; Rizzatti, Fabíola Paula Galhardo

; Fagondes, Simone Chaves

; Magalhães-da-Silveira, Flavio José

; Cabral, Marília Montenegro

; Genta, Pedro Rodrigues

; Lorenzi-Filho, Geraldo

; Clímaco, Danielle Cristina Silva

; Drager, Luciano Ferreira

; Codeço, Vitor Martins

; Viegas, Carlos Alberto de Assis

; Rabahi, Marcelo Fouad

Jornal Brasileiro de Pneumologia

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2022, Volume 48 N. 4 elocation e20220106

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O sono é essencial para o adequado funcionamento de todos os indivíduos. Os distúrbios respiratórios do sono ocorrem em todas as faixas etárias, constituindo motivo frequente de consulta médica. O objetivo deste consenso foi atualizar os conhecimentos sobre os principais distúrbios respiratórios do sono tanto na população adulta quanto na pediátrica, com ênfase na apneia obstrutiva do sono. A apneia obstrutiva do sono é uma doença extremamente prevalente, porém frequentemente subdiagnosticada. Associa-se frequentemente a uma série de comorbidades, notadamente cardiovasculares, metabólicas e neurocognitivas, que impactam significativamente na qualidade de vida e na mortalidade. Por conta disso, o Departamento de Distúrbios Respiratórios do Sono da Sociedade Brasileira de Pneumologia e Tisiologia reuniu 14 especialistas com reconhecida e comprovada experiência em distúrbios respiratórios do sono para a elaboração deste documento.

ABSTRACT Sleep is essential for the proper functioning of all individuals. Sleep-disordered breathing can occur at any age and is a common reason for medical visits. The objective of this consensus is to update knowledge about the main causes of sleep-disordered breathing in adult and pediatric populations, with an emphasis on obstructive sleep apnea. Obstructive sleep apnea is an extremely prevalent but often underdiagnosed disease. It is often accompanied by comorbidities, notably cardiovascular, metabolic, and neurocognitive disorders, which have a significant impact on quality of life and mortality rates. Therefore, to create this consensus, the Sleep-Disordered Breathing Department of the Brazilian Thoracic Association brought together 14 experts with recognized, proven experience in sleep-disordered breathing.

https://doi.org/10.36416/1806-3756/e20220106

14.

Aura de amor sobrenatural (de Apolonio de Tiana a Carlos Fuentes)
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Chaves, José Ricardo

Acta poética

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dec 2021, Volume 42 N. 2 Pages 107 - 127

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract: In this essay the comparative follow-up of the motive of the dis / encounter of lovers belonging to different ontological fields (life / death, wakefulness / sleep), expressed in fantastic figures such as empusas, ghosts and vampires is carried out. The starting point is a story of Apollonius of Tiana according to the text of Philostratus, which was recovered by Goethe in The Bride of Corinth, taken up by 19th Century authors such as Théophile Gautier and Amado Nervo, and reworked by Carlos Fuentes in the 20th Century, in his novel Aura, with the addition of an 18th Century Japanese author, Ueda Akinari, who wrote stories along these lines.

Resumen: En este ensayo se hace el seguimiento comparatista del motivo del des/encuentro de los amantes pertenecientes a ámbitos ontológicos distintos (vida/muerte, vigilia/sueño), expresado en figuras fantásticas como empusas, fantasmas y vampiras. El punto de partida es una historia de Apolonio de Tiana según el texto de Filóstrato, que fue recuperada por Goethe en La novia de Corinto, retomada por autores del siglo XIX como Théophile Gautier y Amado Nervo, y reelaborada por Carlos Fuentes en el siglo XX, en su novela Aura, con el añadido de un autor japonés del siglo XVIII, Ueda Akinari, que escribió historias en esa línea.

https://doi.org/10.19130/iifl.ap.2021.2.18125 301 downloads

15.

Primary health care nurses: attitudes towards the person with mental disorder
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Nóbrega, Maria do Perpétuo Socorro de Sousa

; Fernandes, Carla Sílvia Neves da Nova

; Zerbetto, Sonia Regina

; Sampaio, Francisco Miguel Correia

; Carvalho, José Carlos

; Chaves, Suellen Cristina da Silva

Revista Gaúcha de Enfermagem

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2021, Volume 42 elocation e20200088

Abstract: Pt En Es | Text: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo Identificar as atitudes dos enfermeiros que atuam na Atenção Primária à Saúde frente à pessoa com transtorno mental e as variáveis relacionados aos cuidados de saúde prestados. Metodologia Estudo descritivo, correlacional, com 250 enfermeiros de 69 Unidades Básica de Saúde do município de São Paulo. A coleta de dados ocorreu entre abril e agosto de 2019 por meio da escala “Opiniões acerca da Doença Mental”. Os dados foram analisados por meio do teste de KrusKal-Wallis, com nível de confiança de 95% e significância estatística de p<0,05. Resultados A média global da escala foi 197, que demonstra atitudes negativas especialmente nas dimensões de Autoritarismo (44,6), Restrição Social (42,0), e positiva na dimensão Benevolência (51,7). Conclusão Os enfermeiros apresentam, tendencialmente, perfil atitudinal estigmatizante. É necessária intervenção formativa e permanente para que seja possível reduzir o estigma e melhorar o cuidado de base comunitária preconizado nas diretrizes da Rede de Atenção Psicossocial.

ABSTRACT Objective To identify the attitudes of nurses working in Primary Health Care towards the person with mental disorder and the variables related to health care provided. Methodology Descriptive, correlational study with 250 nurses from 69 Basic Health Units in the city of São Paulo. Data collection took place between April and August 2019 using the “Opinions about Mental Illness” scale. The data were analyzed using the KrusKal-Wallis test, with a 95% confidence level and statistical significance of p <0.05. Results The global mean of the scale was 197, which shows negative attitudes especially in the dimensions of Authoritarianism (44.6), Social Restriction (42.0), and positive in the dimension of Benevolence (51.7). Conclusion Nurses tend to have a stigmatizing attitudinal profile. It is necessary formative and permanent intervention so that it is possible to reduce stigma and improve community-based care recommended in the guidelines of the Psychosocial Care Network.

RESUMEN Objetivo Identificar las actitudes de los enfermeros que trabajan en Atención Primaria de Salud frente a la persona con trastorno mental y las variables relacionadas con la atención médica brindada. Metodología Estudio descriptivo, correlacional con 250 enfermeras de 69 Unidades Básicas de Salud en la ciudad de São Paulo. La recopilación de datos tuvo lugar entre abril y agosto de 2019 utilizando la escala "Opiniones sobre enfermedades mentales". Los datos se analizaron mediante la prueba de KrusKal-Wallis, con un nivel de confianza del 95% y una significación estadística de p <0,05. Resultados El promedio global de la escala fue 197, lo que muestra actitudes negativas especialmente en las dimensiones de Autoritarismo (44.6), Restricción social (42.0), y positivas en la dimensión de Benevolencia (51.7). Conclusión Las enfermeras tienden a tener un perfil de actitud estigmatizante. La intervención formativa y permanente es necesaria para que sea posible reducir el estigma y mejorar la atención comunitaria recomendada en las pautas de la Red de Atención Psicosocial.

https://doi.org/10.1590/1983-1447.2021.20200088 300 downloads

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