Resumo Introdução Pressão arterial (PA) elevada em crianças e adolescentes pode levar à hipertensão na vida adulta. O baixo peso ao nascer (PN) é fator de risco para PA elevada no ciclo da vida. Objetivo Investigar a associação entre peso ao nascer (PN), proxy da nutrição intrauterina, e pressão arterial (PA), enfatizando o papel do estado de peso (EP), de estudantes (6-14 anos), Niterói/RJ. Método Estudo do ciclo da vida, fundamentado na hipótese da programação fetal (HPF): desnutrição intrauterina leva ao aumento da PA. A partir de um estudo seccional, foram aferidas massa corporal, estatura e PA. Os dados foram obtidos de questionários e do Sistema de Informações sobre Nascidos Vivos (1996-2004). Modelos de regressão linear foram analisados com e sem EP. Resultados Em 675 escolares (6-14 anos), 12,4% apresentaram PA elevada, 30,9%, excesso de peso e 5,8% nasceram com baixo peso e, para cada aumento de 100g no PN, a PAS aumentou 0,08mmHg (IC95%:-0,09;0,24) e a PAD 0,02mmHg (IC95%:-0,14;0,18). Nos adolescentes, o aumento de 100g no PN esteve associado a um aumento de 0,14mmHg da PAS (IC95%:-0,08;0,37) e de 0,02mmHg da PAD (IC95%:-0,13;0,17), com ajuste múltiplo (incluindo EP). Conclusão PN e PA estiveram positivamente associados, não corroborando com a HPF. Nos escolares com excesso de peso, a PA foi mais alta entre aqueles que nasceram com baixo peso, sugerindo a necessidade de prevenir a inadequação do peso desde a fase intrauterina. (PA adulta (PN , PA, EP, EP (EP) 614 6 14 (6-1 anos, anos anos) NiteróiRJ Niterói RJ Niterói/RJ HPF (HPF) seccional corporal 19962004. 19962004 1996 2004 . (1996-2004) 67 124 12 4 12,4 309 30 9 30,9% 58 5 8 5,8 g 008mmHg mmHg 0 08mmHg IC95%0,090,24 IC95009024 IC IC95% 0,09 0,24 IC95 09 24 (IC95%:-0,09;0,24 002mmHg 02mmHg IC95%0,140,18. IC95014018 0,14 0,18 18 (IC95%:-0,14;0,18) 014mmHg 14mmHg IC95%0,080,37 IC95008037 0,08 0,37 08 37 (IC95%:-0,08;0,37 IC95%0,130,17, IC95013017 0,13 0,17 13 17 (IC95%:-0,13;0,17) incluindo EP) associados (EP 61 1 (6- (HPF 1996200 199 200 (1996-2004 12, 3 30,9 5, 090 IC95%0,090,2 IC9500902 009 0,0 024 0,2 IC9 2 (IC95%:-0,09;0,2 140 IC95%0,140,18 IC9501401 014 0,1 018 (IC95%:-0,14;0,18 080 IC95%0,080,3 IC9500803 008 037 0,3 (IC95%:-0,08;0,3 130 IC95%0,130,17 IC9501301 013 017 (IC95%:-0,13;0,17 (6 199620 19 20 (1996-200 30, IC95%0,090, IC950090 00 0, 02 (IC95%:-0,09;0, IC95%0,140,1 IC950140 01 (IC95%:-0,14;0,1 IC95%0,080, IC950080 03 (IC95%:-0,08;0, IC95%0,130,1 IC950130 (IC95%:-0,13;0,1 ( 19962 (1996-20 IC95%0,090 IC95009 (IC95%:-0,09;0 IC95%0,140, IC95014 (IC95%:-0,14;0, IC95%0,080 IC95008 (IC95%:-0,08;0 IC95%0,130, IC95013 (IC95%:-0,13;0, (1996-2 IC95%0,09 IC9500 (IC95%:-0,09; IC95%0,140 IC9501 (IC95%:-0,14;0 IC95%0,08 (IC95%:-0,08; IC95%0,130 (IC95%:-0,13;0 (1996- IC95%0,0 IC950 (IC95%:-0,09 IC95%0,14 (IC95%:-0,14; (IC95%:-0,08 IC95%0,13 (IC95%:-0,13; (1996 IC95%0, (IC95%:-0,0 IC95%0,1 (IC95%:-0,14 (IC95%:-0,13 (199 IC95%0 (IC95%:-0, (IC95%:-0,1 (19 (IC95%:-0 (1 (IC95%:- (IC95%: (IC95% (IC95 (IC9 (IC
Abstract Background High blood pressure (BP) in children and adolescents can lead to hypertension in adulthood. Low birth weight (BW) is a risk factor for high BP throughout the life cycle. Objective To investigate the association between birth weight (BW) as an intrauterine nutrition proxy and blood pressure (BP), emphasizing the role of weight state (WS), in 6-14-year-old students from Niterói/RJ. Method Life course study based on the fetal programming hypothesis (FPH): intrauterine malnutrition leads to increased blood pressure. From a sectional survey, in which body mass, height, and BP were measured. Questionnaires and the Live Birth Information System were sources of information (1994-2004). Multiple linear regression models were analyzed with and without WS. Results In 675 students (aged 6-14), 12.4% had high blood pressure, and 30.9%, were overweight. Low birth weight was identified in and 5.8%, and for each 100g increase in the BW, the SBP increased 0.07 mmHg (95% CI -0.09 –0.24); and the DBP 0.02 mmHg (95% CI: -0.14; 0.18). In teenager students, a BW increase of 100 g was related to an increase of 0.14mmHg of SBP (95% CI: -0.08;0.37) and 0.02mmHg of DBP (95% CI: -0.15–0.17), with multiple adjustments (including WS). Conclusion BW and BP were positively associated, thus not correlating to the FPH. In overweight students, BP was higher among those born with low weight, suggesting the need to prevent inadequate weight in the intrauterine phase. (BP adulthood (BW cycle BP, , WS, WS (WS) 614yearold yearold 6 14 year old NiteróiRJ Niterói RJ Niterói/RJ FPH (FPH) survey mass height measured 19942004. 19942004 1994 2004 . (1994-2004) 67 aged 614, 614 6-14) 124 12 4 12.4 309 30 9 30.9% 58 5 8 5.8% 007 0 07 0.0 95% 95 (95 0.09 009 09 -0.0 –0.24 024 24 –0.24) 002 02 0.14 014 -0.14 0.18. 018 0.18 18 0.18) 10 014mmHg 14mmHg 0.080.37 008037 0.08 0.37 08 37 -0.08;0.37 002mmHg 02mmHg 0.15–0.17, 015017 0.15–0.17 15 17 -0.15–0.17) including WS) associated phase (WS 1 (FPH 1994200 199 200 (1994-2004 61 6-14 12. 3 30.9 5.8 00 0. (9 -0. –0.2 2 0.1 01 -0.1 080 0.080.3 00803 008 037 0.3 -0.08;0.3 01501 0.15–0.1 -0.15–0.17 199420 19 20 (1994-200 6-1 30. 5. ( -0 –0. 0.080. 0080 03 -0.08;0. 0150 0.15–0. -0.15–0.1 19942 (1994-20 6- - –0 0.080 -0.08;0 015 0.15–0 -0.15–0. (1994-2 – -0.08; 0.15– -0.15–0 (1994- -0.08 0.15 -0.15– (1994 -0.15 (199 (19 (1