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Abstract Ovine Enzootic Abortion (OEA) is caused by Chlamydia abortus and has recently been recognized as endemic in Mexico. Due to the impact of OEA on intensive lamb production, it is necessary to establish a sanitary control plan based on an efficient diagnosis. The loop-mediated isothermal amplification technique (LAMP) is a molecular test that can specifically identify C. abortus. The aim of this study was to standardize the LAMP technique for the specific detection of C. abortus in ovine vaginal exudates. Primers were identified and modified from an electronic database. The effective conditions of the technique were determined using synthetic DNA and positive biological samples by PCR as references. The assay detection limit was 1 × 10-5 of genetic material, equivalent to 8.5 copies. The standardized LAMP test is proposed as a novel molecular tool for the rapid and specific diagnosis of C. abortus infection from ovine vaginal exudate samples in Mexico.

Resumen El Aborto Enzoótico Ovino (AEO) es causado por Chlamydia abortus y ha sido reconocido recientemente como endémico en México. Debido al impacto del AEO en la producción intensiva de corderos, es necesario establecer un plan de control sanitario basado en un diagnóstico eficiente. La técnica de amplificación isotérmica mediada por bucle (LAMP) es una prueba molecular que puede identificar específicamente a C. abortus. El objetivo de este estudio fue estandarizar la técnica de LAMP para la detección específica de C. abortus a partir de exudado vaginal ovino. Los cebadores fueron identificados y modificados a partir de una base de datos electrónica. Las condiciones efectivas de la técnica se determinaron con ADN sintético y de muestras biológicas positivas por PCR como referencia. El límite de detección de la prueba fue de 1 × 10-5 de material genético, equivalente a 8.5 copias. Se propone el test de LAMP estandarizado como una nueva herramienta molecular para el diagnóstico rápido y específico de la infección por C. abortus a partir de muestras de exudado vaginal ovino en México.

https://doi.org/10.18633/biotecnia.v26i1.2109

[SciELO Preprints] - Risk of Adverse Health Outcomes in Patients with Poor Adherence to Cardiovascular Medication Treatment: a Systematic Review
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Malachias, Marcus Vinícius Bolívar Kaiser, Sergio Emanuel Albuquerque, Denilson Campos de Brandão, Andréa Araujo Sposito, Andrei C. Moura, Lidia Zytynski Magalhães, Lucélia Batista Neves Cunha Mota-Gomes, Marco Antonio Clausell, Nadine Jardim, Paulo César Veiga Nadruz, Wilson Barros, Bruno Monteiro Luna , Leonardo Castro Barroso, Weimar Kunz Sebba

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Publication date: 2024-09-16

Abstract: Pt En

Introdução: As doenças cardiovasculares (DCV) continuam a ser a principal causa de mortalidade em todo o mundo. A adesão ao tratamento medicamentoso é uma questão importante no manejo das DCV crônicas, influenciando diretamente os resultados e os custos com saúde. Objetivos: Esta revisão sistemática, apoiada pela Sociedade Brasileira de Cardiologia, avalia o impacto da baixa adesão aos medicamentos cardiovasculares em desfechos clínicos críticos, como morte e eventos cardiovasculares. Métodos: Foi realizada uma busca abrangente em quatro bases de dados, incluindo Medline, Embase, Lilacs e Cochrane Library. A revisão incluiu revisões sistemáticas com meta-análises que relataram estimativas de risco para a adesão aos medicamentos cardiovasculares. Foram selecionadas quatro revisões sistemáticas, cada uma incorporando estudos observacionais. Resultados: Os principais achados indicam que um aumento na adesão aos medicamentos reduz significativamente o risco de eventos cardiovasculares, acidente vascular cerebral (AVC) e morte por todas as causas. Especificamente, uma melhoria de 20% na adesão a medicamentos antihipertensivos, hipolipemiantes e outros medicamentos cardiovasculares correlacionou-se com reduções nos eventos cardiovasculares de 7%, 10% e 9%, respectivamente; AVC de 17%, 13% e 18%; e morte de 12%, 9% e 10%. A certeza das evidências foi moderada, sugerindo que esses efeitos provavelmente estão presentes. Esses achados enfatizam a importância de melhorar a adesão ao tratamento medicamentoso para aprimorar os resultados clínicos no manejo das DCV. Conclusões: As evidências demonstraram reduções em desfechos duros tanto na prevenção primária quanto secundária através do controle de condições como hipertensão e concentrações elevadas de colesterol LDL, bem como os benefícios da terapia antiplaquetária em doenças ateroscleróticas. No entanto, são necessários estudos adicionais para elucidar melhor a relação entre a adesão aos medicamentos cardiovasculares e a melhoria dos desfechos clínicos críticos.

Background: Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. Medication adherence is an important issue in managing chronic CVD, directly influencing outcomes and healthcare costs. Objectives: This systematic review, supported by the Brazilian Society of Cardiology, evaluates the impact of poor adherence to cardiovascular medications on critical clinical outcomes such as death and cardiovascular events. Methods: A comprehensive search was conducted across four databases, including Medline, Embase, Lilacs, and the Cochrane Library. The review included systematic reviews with meta-analyses that reported risk estimates for adherence to cardiovascular medications. Four systematic reviews, each incorporating observational studies, were selected. Results: The principal findings indicate that an increase in adherence to medications significantly reduces the risk of cardiovascular events, stroke, and all-cause death. Specifically, a 20% improvement in adherence to antihypertensive, lipid-lowering, and other cardiovascular medications correlated with reductions in cardiovascular events by 7%, 10%, and 9%, respectively; stroke by 17%, 13%, and 18%; and death by 12%, 9%, and 10%. The certainty of the evidence was moderate, suggesting that these effects are likely present. These findings emphasize the importance of enhancing medication adherence to improve clinical outcomes in CVD management. Conclusions: Evidence has demonstrated reductions in hard endpoints in both primary and secondary prevention through the control of conditions such as hypertension and elevated LDL cholesterol concentrations, as well as the benefits of antiplatelet therapy in atherosclerotic disease. However, additional studies are needed to better elucidate the relationship between adherence to cardiovascular medications and the improvement of critical clinical outcomes.

https://doi.org/10.1590/SciELOPreprints.9997

Doença Hepática Esteatótica Associada a Disfunção Metabólica: Uma Atualização do Rastreio e Opções Terapêuticas
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Fernandes, Luís Neto

; Castro, Sofia Osório de

; Santos, Sara S.

; Ferreira, Sérgio Gomes

; Andrade, Luís

; Henriques, Cátia

Medicina Interna

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sep 2024, Volume 31 N. 3 Pages 51 - 58

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common forms of chronic liver disease, particularly associated with obesity and type 2 diabetes mellitus. The prevalence has been increasing in recent years, currently affecting around 25% of the world's population. The hallmark of its pathophysiology lies in insulin resistance and the accumulation of fat inside hepatocytes. Several clinical scores allow cost-effective screening, such as FIB-4 and NFS. Although it is considered the gold standard, liver biopsy can often be avoided by using hepatic elastography. Numerous drugs used in diabetes have therapeutic potential in metabolic dysfunction-associated steatotic liver disease, with the most studied class being GLP-1 receptor agonists. The bidirectional pathophysiological as-sociation between metabolic dysfunction-associated steatotic liver disease and diabetes will enable the development of this field and the emergence of new therapies.

Resumo A doença hepática esteatótica associada a disfunção metabólica, em inglês metabolic dysfunction-associated steatotic liver disease (MASLD), previamente conhecida como fígado gordo não alcoólico, é das formas mais comuns de doença hepática crónica, estando particularmente associada com a obesidade e diabetes mellitus tipo 2. A sua prevalência tem aumentado nos últimos anos, afetando, neste momento, cerca de 25% da população mundial. A génese da sua fisiopatologia reside na insulinorresistência e acumulação de gordura no interior dos hepatócitos. Existem vários scores clínicos que permitem o seu rastreio de forma custo-efetiva, como o FIB-4 e NFS. Apesar de ser considerada como gold-standard, a biópsia hepática pode ser dispensada na maioria das vezes através do uso da elastografia hepática. Inúmeros fármacos utilizados na diabetes têm potencialidade terapêutica na doença hepática esteatótica associada a disfunção metabólica, sendo a classe mais estudada os agonistas do recetor GLP-1. A associação fisiopatológica bidirecional entre a doença hepática esteatótica associada a disfunção metabólica e a diabetes irá permitir o desenvolvimento desta área e o surgimento de novas terapêuticas.

https://doi.org/10.24950/rspmi.2522

La comunidad como apoyo en la socialización de los niños con trastorno del espectro autista
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Castro Gell, Yadira

; Aragonés Lafita, Lisbet

; Ramírez Gell, Sergio

Varona. Revista Científico Metodológica

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aug 2024, N. 80 elocation e2607

Abstract: Es En | Text: Es En | PDF: Es | PDF: En

RESUMEN El desarrollo que alcance un infante con repercusión en el resto de su vida adulta, será resultado tanto, de la interacción de sus características biológicas y psicológicas, como de las experiencias que le ofrezca su medio social. De ahí que se afirme el carácter biopsicosocial de los seres humanos y que se valore la socialización desde las primeras edades, por lo positivo y estimulante en su desarrollo. Sin embargo, en ocasiones, esa interacción es limitada por disímiles factores, que pueden partir desde el propio individuo, poseedor de determinadas características que condicionan su interacción con el medio y la particularizan; de la familia como ente propiciador o represor de la misma; de la propia sociedad o comunidad que la favorezca, promueva o estimule. Tal es el caso de los niños con necesidades educativas especiales, neurodivergentes y en situación de discapacidad. En coherencia, se diseñó un proyecto comunitario contentivo de acciones que contribuyen a la socialización y la estimulación del desarrollo de niños neurodivergentes, con énfasis en aquellos diagnosticados con trastorno del espectro autista (TEA). Prevalecen en el estudio los métodos: revisión bibliográfica, análisis-síntesis, entrevistas y observación. Los resultados proyectan la satisfacción de necesidades educativas básicas para la inclusión socioeducativa.

ABSTRACT The development that an infant achieves with repercussions on the rest of his or her adult life will be the result of both the interaction of her biological and psychological characteristics and the experiences that her social environment offers her. Hence, the biopsychosocial character of human beings is affirmed and socialization is valued from the earliest ages, due to its positive and stimulating development. However, sometimes, this interaction is limited by dissimilar factors, which can come from the individual himself, who possesses certain characteristics that condition his interaction with the environment and make it particular; of the family as an entity that promotes or represses it; of the society or community itself that favors, promotes or stimulates it. This is the case of children with special educational needs, neurodivergents and those with disabilities. In coherence, a community project was designed containing actions that contribute to the socialization and stimulation of the development of neurodivergent children, with emphasis on those diagnosed with autism spectrum disorder (ASD). The methods prevail in the study: bibliographic review, analysis- synthesis, interviews and observation. The results project the satisfaction of basic educational needs for socio-educational inclusion.

Alert for the high prevalence of vitamin D deficiency in adolescents in a large Brazilian sample
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Radonsky, Vanessa

; Lazaretti-Castro, Marise

; Chiamolera, Maria Izabel

; Biscolla, Rosa Paula Mello

; Lima Junior, José Viana

; Vieira, José Gilberto Henriques

; Brandão, Cynthia Maria Alvares

; Ramalho, Rodrigo Fernandes

; Maeda, Sergio Setsuo

; Cavichio, Marcia Wehba Esteves

Jornal de Pediatria

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aug 2024, Volume 100 N. 4 Pages 360 - 366

Abstract: En | Text: En | PDF: En

Abstract Objective: To estimate the prevalence of vitamin D deficiency and severe deficiency in children and adolescents, in a large Brazilian sample. Methodology: Results of 413,988 25(OH)D measurements in children and adolescents aged 0 to 18 years collected between 01/2014 and 10/2018 were obtained from the database of a Clinical Laboratory. In this population, 25 hydroxyvitamin D concentrations below 20 ng/mL are considered deficient, and below 12 ng/mL as severe deficiency. All measurements were performed by immunoassay and the results were distributed by gender, age group, seasonality, and latitude. Results: The mean of 25(OH)D levels was 29.2 ng/mL with a standard deviation of 9.2 ng/mL. Of the total samples, 0.8% had a concentration < 12 ng/mL, and 12.5% of the samples had a concentration < 20 ng/mL, with a higher prevalence in females. Children under 2 years of age had the lowest prevalence. The effects of latitude and seasonality were quite evident. In samples of female adolescents from the southern region in winter, 36% of vitamin D deficiency and 5% of severe deficiency were found. Conclusion: In this large number of measurements of 25(OH)D in children and adolescents, 12.5% had a deficiency and 0.8% had severe deficiency. A greater deficiency was observed among adolescents, especially females, which raises questions about the need for supplementation during this period of life. Objective sample Methodology 413988 413 988 413,98 25OHD OHD OH 1 012014 01 2014 01/201 102018 10 2018 10/201 Laboratory population ngmL ng mL deficient gender group 292 29 29. 92 9 9. 08 8 0.8 125 5 12.5 females evident winter 36 found Conclusion life 41398 41 98 413,9 01201 201 01/20 10201 10/20 0. 12. 3 4139 4 413, 0120 01/2 1020 10/2 012 01/ 102 10/

https://doi.org/10.1016/jped.2024.01.003

Efecto de la fertilización sobre el crecimiento temprano de clones de Gmelina arborea Roxb. ex Sm. en el Pacífico Norte y Sur de Costa Rica
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Carvajal Arroyo, David Antonio

; Murillo Cruz, Rafael

; Alvarado Hernández, Alfredo

; Ávila Arias, Carlos

; González Rojas, Mariela

; Hernández Castro, William

; Molina-Murillo, Sergio

Revista de Ciencias Ambientales

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jun 2024, Volume 58 N. 1 elocation 18118

Abstract: En Es | Text: En Es | PDF: En | PDF: Es

Abstract (Introduction): The productive capacity of a forest plantation depends mainly on the physicochemical characteristics of the soil, as well as the necessary silvicultural management for optimal tree development. (Objective): The objective of this research was the evaluation of the effect of fertilization on clonal forest plantations of Gmelina arborea Roxb. ex Sm. 3 years old, in the North and South Pacific of Costa Rica. (Methodology): The study was carried out in 2 experimental trials of the Forestry Research and Services Institute located in La Esperanza, Cóbano (trial 1) and in Rancho Quemado, Drake Bay (trial 2). Five complete blocks were established at random with four fertilization treatments with the fertilizer 19-4-19-2-0.1(B)-1.8(S)-.1(Zn). An analysis of variance and comparison of means of the mean annual increments of DBH, height and total volume of the trees was carried out, using the Tukey test. (Results): The results show that the site with the highest natural fertility presents a greater growth of the trees, however, there are no statistically significant differences between all the treatments applied. The site with the lowest natural fertility is located in Bahía Drake and it did present statistically significant differences in some treatments in terms of total volume. (Conclusions): Continuous fertilization have a positive impact on the dasometric growth in G. arborea plantations that present low calcium contents (< 4.5 cmol L-1), low values of effective cation exchange capacity (<7.8 cmol L-1) and high acidity saturation (> 19.4 %).

Resumen (Introducción): La capacidad productiva de una plantación forestal depende principalmente de las características fisicoquímicas del suelo, así como del manejo silvicultural necesario para un óptimo desarrollo de los árboles. (Objetivo): El objetivo de esta investigación fue la evaluación del efecto de la fertilización sobre plantaciones forestales clonales de Gmelina arborea Roxb. ex Sm., de tres años, en el Pacífico Norte y Sur de Costa Rica. (Metodología): El estudio se realizó en 2 ensayos experimentales del Instituto de Investigación y Servicios Forestales ubicados en La Esperanza, Cóbano (ensayo 1) y en Rancho Quemado, Bahía Drake (ensayo 2). Se establecieron 5 bloques completos, al azar, con 4 tratamientos de fertilización con el abono 19-4-19-2-0,1(B)-1,8(S)-,1(Zn). Se realizó un análisis de varianza y comparación de medias de los incrementos medios anuales del DAP, la altura y el volumen total de los árboles utilizando la prueba de Tukey. (Resultados): Los resultados muestran que el sitio con mayor fertilidad natural presenta aumento en el crecimiento de los árboles; sin embargo, no existen diferencias estadísticamente significativas entre todos los tratamientos aplicados. El sitio de menor fertilidad natural se ubica en Bahía Drake y presentó diferencias estadísticamente significativas en algunos tratamientos en términos de volumen total. (Conclusiones): La fertilización continua tienen un impacto positivo en el crecimiento dasométrico en plantaciones de G. arborea que presenten bajos contenidos de calcio (< 4.5 cmol L-1), valores bajos en capacidad de intercambio catiónico efectiva (< 7.8 cmol L-1) y alta saturación de acidez (> 19.4 %).

https://doi.org/10.15359/rca.58-1.3

Visual assessment of leaf area index in coffee (Coffea arabica L.) fields Coffea L. L
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Castro-Pacheco, Sergio A.

; González-Lutz, María I.

; Araya-Alfaro, José M.

; Vargas-Chinchilla, Mariano

; Gutiérrez-Soto, Marco V.

Revista Brasileira de Engenharia Agrícola e Ambiental

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mar 2024, Volume 28 N. 3 elocation e274355

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO A aplicação do índice de área foliar (IAF) na gestão da cultura do cafeeiro depende da disponibilidade de metodologias para sua estimativa correta. É proposta aqui uma metodologia para a avaliação visual do IAF em plantas de café, por tanto se estabelece um protocolo para o treinamento dos avaliadores. Foram feitas quatro rodadas de medições do IAF utilizando estimativas visuais, dois instrumentos (LAI 2200-C e AccuPAR LP-80), e desfolhações de sebes de café na Costa Rica. A cada rodada, cinco trabalhadores estimaram visualmente os valores do IAF em duas ocasiões e separados por 15 dias. Ao final de cada rodada, foi dada uma retroalimentação a cada trabalhador. A avaliação visual mostrou alta repetibilidade e reprodutibilidade, e as estimativas foram ajustadas para o modelo de regressão linear na maioria dos casos. Os avaliadores melhoraram sua capacidade de avaliar visualmente o IAF ao longo das rodadas, e o valor de R2 aumentou consistentemente para a maioria dos trabalhadores, com valores tão altos quanto 0,87. A avaliação do IAF por instrumentos produziu valores de R2 de 0,5-0,6, com significativa tendência de subestimação, e não se ajustou ao modelo de regressão linear. O desempenho dos diferentes métodos é discutido no contexto de coberturas com amplo espaço. A metodologia visual proposta constitui uma determinação sólida, rápida, simples e confiável do IAF na lavoura do café e considera-se uma ajuda na tomada de decisões para a gestão da safra. (IAF correta visuais LAI 2200C C 2200 LP80, LP80 LP 80 , LP-80) Rica rodada 1 dias trabalhador reprodutibilidade casos R 087 0 87 0,87 0,50,6, 0506 0,5 0,6, 5 6 0,5-0,6 subestimação espaço sólida rápida considerase considera safra 220 LP8 8 LP-80 08 0,8 50 0,50,6 050 05 0, 06 0,6 0,5-0, 22 LP-8 0,50, 0,5-0 2 LP- 0,50 0,5-

ABSTRACT The application of leaf area index (LAI) in coffee crop management depends on the availability of methodologies for proper estimation. The objective of this study was to develop a methodology for the visual assessment of LAI in coffee fields and to establish a protocol for training, evaluation, and feedback for evaluators. Four rounds of LAI measurements were conducted using visual estimates, two instruments (LAI 2200-C and AccuPAR LP-80), and defoliation of coffee hedgerows in Poás, Costa Rica. In each round, five workers visually estimated the LAI values on two occasions separated by 15 days, and feedback reinforcement was provided to each worker at the end of each round. Visual assessments showed high repeatability and reproducibility and the estimates were adjusted to the linear regression model in most cases. Evaluators improved their capacity to visually assess the LAI throughout the rounds, as the value of R2increased consistently for most workers, with values as high as 0.87. Instrumentation evaluation of LAI produced R2values of 0.5-0.6, with significant underestimation bias. The performance of the different methods is discussed in the context of widely spaced hedgerows. The proposed visual methodology constitutes a statistically sound, rapid, simple, and reliable method for determining the LAI of coffee fields to aid in decision-making for crop management. estimation training evaluators 2200C C 2200 LP80, LP80 LP 80 , LP-80) Poás Rica round 1 days cases Rincreased R increased 087 0 87 0.87 Rvalues 0.50.6, 0506 0.5 0.6, 5 6 0.5-0.6 bias sound rapid simple decisionmaking decision making 220 LP8 8 LP-80 08 0.8 50 0.50.6 050 05 0. 06 0.6 0.5-0. 22 LP-8 0.50. 0.5-0 2 LP- 0.50 0.5-

https://doi.org/10.1590/1807-1929/agriambi.v28n3e274355

Serological evidence of Leptospiraspp. infection in livestock from indigenous villages in the Caatinga biome, Brazil Leptospiraspp biome
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Oliveira, Matheus Carvalho Freire de

; Santos, José Felipe Napoleão

; Medeiros, Avana Maria Lucena Alencar de

; Castro, Vanessa

; Bezerra, Camila de Sousa

; Alves, Clebert José

; Azevedo, Sérgio Santos de

; Santos, Carolina de Sousa Américo Batista

Ciência Rural

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2024, Volume 54 N. 5 elocation e20230191

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A leptospirose causa perdas econômicas na pecuária e é um problema de saúde pública, sendo possível que existam peculiaridades na epidemiologia dessa doença em aldeias indígenas, principalmente naquelas de áreas de clima semiárido, como o bioma Caatinga no Nordeste do Brasil, onde o ambiente é frequentemente adverso à sobrevivência de leptospiras. Assim, o objetivo deste estudo foi realizar o diagnóstico sorológico em rebanhos de aldeias indígenas no bioma Caatinga. A pesquisa foi realizada nas aldeias indígenas Mãe Maria e Santa Helena, tribo Xukuru de Cimbres, município de Pesqueira, estado de Pernambuco, Brasil, dentro do bioma Caatinga. Amostras de sangue foram colhidas de bovinos (n = 42), caprinos (n = 41) e ovinos (n = 19). No geral, das 102 amostras testadas 73 (71,6%; IC 95% = 62,8% - 80,3%) foram sororreativas (ponto de corte ≥ 100). Para bovinos, caprinos e ovinos as taxas de soropositividade foram de 54,8%, 80,5% e 89,5%, respectivamente. Houve diferença estatística na proporção de animais soropositivos entre bovinos e caprinos e bovinos e ovinos (P < 0,05). Icterohaemorrhagiae foi o sorogrupo mais provável em todas as espécies animais. O estudo mostra que animais de produção de aldeias indígenas são comumente expostos a leptospiras no bioma Caatinga, o que constitui uma preocupação do ponto de vista de Saúde Única e demonstra a importância de estudos amplos em que coexistem grandes números de humanos e animais na investigação de infecções zoonóticas e no planejamento e implementação de medidas de controle da leptospirose associada a animais de produção. RESUMO pública semiárido Brasil Assim Helena Cimbres Pesqueira Pernambuco n 42, 42 , 42) 41 19. 19 . 19) geral 10 7 71,6% 716 71 6 (71,6% 95 628 62 8 62,8 80,3% 803 80 3 100. 100 100) 548 54 54,8% 805 5 80,5 895 89 89,5% respectivamente P 0,05. 005 0,05 0 05 0,05) 4 1 71,6 (71,6 9 62, 80,3 54,8 80, 89,5 00 0,0 71, (71, 54, 89, 0, (71 (7 (

ABSTRACT: Leptospirosis, a disease of significant economic impact on livestock and public health concern, may exhibit unique epidemiological characteristics in indigenous villages, particularly those located within semiarid climates such as the Caatinga biome in Brazil. This environment often presents conditions unfavorable for leptospire survival. This study conducted serological diagnoses of livestock in indigenous villages within the Caatinga biome, Northeastern Brazil. The survey was carried out in the Mãe Maria and Santa Helena indigenous villages, home to the Xukuru de Cimbres tribe, in the county of Pesqueira, Pernambuco State, Brazil, within the Caatinga biome. Blood samples were collected from cattle (n = 42), goats (n = 41), and sheep (n = 19). Out of the 102 samples tested, 73 (71.6%; 95% CI = 62.8% - 80.3%) were seroreactive (cut-off ≥ 100). The seropositivity rates for cattle, goats, and sheep were 54.8%, 80.5%, and 89.5%, respectively. A statistically significant difference was observed in the proportion of seropositive animals between cattle and goats and cattle and sheep (P < 0.05). Icterohaemorrhagiae was identified as the most probable serogroup across all animal species. The study revealed that livestock in indigenous villages within the Caatinga biome are frequently exposed to leptospires. This finding underscores the importance of a One Health approach, emphasizing the need for comprehensive studies in areas where large human and animal populations coexist. Such studies are crucial for investigating zoonotic infections and for planning and implementing control measures against livestock-associated leptospirosis. ABSTRACT Leptospirosis concern Brazil survival tribe Pesqueira State n 42, 42 , 42) 41, 41 41) 19. 19 . 19) 10 tested 7 71.6% 716 71 6 (71.6% 95 628 62 8 62.8 80.3% 803 80 3 cutoff cut off 100. 100 100) 548 54 54.8% 805 5 80.5% 895 89 89.5% respectively P 0.05. 005 0.05 0 05 0.05) species leptospires approach coexist livestockassociated associated leptospirosis 4 1 71.6 (71.6 9 62. 80.3 54.8 80.5 89.5 00 0.0 71. (71. 80. 54. 89. 0. (71 (7 (

https://doi.org/10.1590/0103-8478cr20230191

Comparison between continuous and pulsed low-intensity laser on the healing of skin grafts applied to recently created wounds in rabbits (Oryctolagus cuniculus) lowintensity low intensity Oryctolagus cuniculus
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Reis Filho, Nazilton de Paula

; Ferreira, Marília Gabriele Prado Albuquerque

; Pascoli, Ana Lucia de Carvalho Rosa

; Pazzini, Josiane Morais

; Paiva, Felipe Noleto de

; Ferrari, Bruno Santos

; Floriano, Beatriz Peres

; Moraes, Paola Castro

; Ferraudo, Antonio Sergio

; Nardi, Andrigo Barboza de

Ciência Rural

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2024, Volume 54 N. 4 elocation e20220649

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: A enxertia cutânea é uma técnica cirúrgica simples e bastante útil para o reparo de feridas, principalmente, quando há dificuldade em realizar a síntese direta ou outras técnicas reconstrutivas. O laser de baixa intensidade (LBI) já foi utilizado com sucesso em casos em que o enxerto foi aplicado em feridas logo após a sua criação. No entanto, a LBI ainda carece de padronizações, mediante estudos conflitantes sobre seus resultados. Desta forma, este trabalho objetivou comparar a eficácia da LBI de onda contínua com onda pulsada na estimulação da cicatrização de enxertos cutâneos, aplicados em feridas recém-criadas em coelhos. Para tanto, foram utilizados 31 coelhos distribuídos em: grupo controle (GC, n = 10), grupo laser onda contínua (GLC; n = 10) e grupo laser onda pulsada (GLP; n = 11). O manejo pós operatório foi semelhante entre todos os grupos, com exceção da aplicação do laser, conforme o grupo indicado. Os grupos GLC e GLP apresentaram evolução semelhante, com processo cicatricial satisfatório do enxerto, ao contrário do grupo GC. Tais resultados se mantiveram na avaliação microscópica, pois os grupos tratados com laser apresentaram menor inflamação, melhor integração à área receptora, maior reepitelização e colagenização. Não houve diferença na densidade vascular entre os grupos de tratamento na análise imuno-histoquímica. A ferida recém-criada não é capaz de fornecer nutrição para o enxerto cutâneo nos coelhos, mas a LBI é uma terapia adjuvante eficiente em estimular a cicatrização entre a área receptora e o enxerto, promovendo integração total. Entretanto, embora não houve diferença estatística na forma de emissão de luz, pulsada ou contínua, os pacientes que receberam LBI em onda contínua apresentam evolução microscópica superior. RESUMO principalmente reconstrutivas (LBI criação entanto padronizações cutâneos recémcriadas recém criadas tanto 3 GC, GC (GC 10, 10 , (GLC (GLP 11. 11 . 11) indicado inflamação colagenização imunohistoquímica. imunohistoquímica imuno histoquímica. histoquímica imuno-histoquímica recémcriada criada total Entretanto luz superior 1

ABSTRACT: Skin grafting is a simple and very useful surgical technique for wound repair, especially where there is difficulty in performing direct synthesis or other reconstructive techniques. low-intensity laser (LIL) has already been used successfully in cases where the graft was applied to wounds shortly after its creation. However, LIL still lacks standardization due to conflicting studies on its results. Thus, this study compared the effectiveness of continuous wave LIL with pulsed wave LIL in stimulating the healing of skin grafts, applied to newly created wounds in rabbits. For this purpose, 31 rabbits were distributed into: control group (CG, n = 10), continuous wave laser group (GLC; n = 10) and pulsed wave laser group (GLP; n = 11). Postoperative management was similar between all groups, with the exception of laser application, as indicated by the group. The GLC and GLP groups showed similar evolution, with a satisfactory healing process of the graft, unlike the GC group. These results were maintained in the microscopic evaluation, as the groups treated with laser showed less inflammation, better integration with the receptor area, greater re-epithelialization and collagenization. There was no difference in vascular density between the treatment groups on immunohistochemical analysis. The newly created wound was not able to provide nutrition for the skin graft in rabbits, but LIL is an efficient adjuvant therapy in stimulating healing between the recipient area and the graft, promoting full integration. However; although, statistically there was no difference in the form of light emission, pulsed or continuous, patients who received continuous wave LIL showed superior microscopic evolution. ABSTRACT repair techniques lowintensity low intensity (LIL creation However Thus grafts purpose 3 into CG, CG (CG 10, 10 , (GLC (GLP 11. 11 . 11) application evolution evaluation inflammation reepithelialization re epithelialization collagenization analysis although emission 1

https://doi.org/10.1590/0103-8478cr20220649

10.

Prevalence and factors associated with dyslipidemia in children aged 6 to 42 months in a Brazilian capital
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Abreu, Vanessa Roriz Ferreira de

; Lobo, Lina Monteiro de Castro

; Schincaglia, Raquel Machado

; Costa, Paulo Sérgio Sucasas da

; Braudes-Silva, Lana Angélica

; Hadler, Maria Claret Costa Monteiro

Cadernos de Saúde Pública

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2024, Volume 40 N. 9 elocation e00202123

Abstract: Es En Pt | Text: Es En Pt | PDF: Es | PDF: En | PDF: Pt

El objetivo de este estudio fue evaluar la prevalencia y los factores asociados con las anomalías del perfil lipídico en niños de 6 a 42 meses de edad en una ciudad del Centro-Oeste de Brasil. Este estudio transversal utilizó datos de referencia de un ensayo clínico aleatorizado por grupos realizado en paralelo. Se evaluó el perfil lipídico, la ingesta habitual de nutrientes (pesaje directo de alimentos y recordatorio de alimentación de 24 horas), los parámetros antropométricos y los aspectos socioeconómicos de 169 niños de centros de educación infantil. Se realizó una regresión de Poisson con un análisis robusto de la varianza. Se reveló que el 85% de los participantes tenían dislipidemia; el 72% presentaron niveles de lipoproteínas de alta densidad (HDL-c) por debajo del rango esperado; el 49% tenía aumento de triglicéridos (TG); el 17% de lipoproteínas de baja densidad (LDL-c) elevadas y el 15% tenía colesterol total (CT) elevado. Un aumento en el índice de masa corporal (IMC) para la puntuación z de la edad se asoció con una mayor tendencia a aumento de TG (RP = 1,22; IC95%: 1,05-1,41; p = 0,009). La edad más avanzada de los niños se asoció con una mayor prevalencia de LDL-c alta (RP = 1,037; IC95%: 1,01-1,07; p = 0,022) y CT (RP = 1,036; IC95%: 1,00-1,07; p = 0,037), pero fue un factor de protección contra HDL-c baja (RP = 0,991; IC95%: 0,98-1,00; p = 0,042). La ingesta alta de energía se asoció con HDL-c baja (RP = 1,001; IC95%: 1,00-1,00; p = 0,023). Se encontraron que la mayor tendencia a aumento de LDL-c (RP = 1,005; IC95%: 1,00-1,01; p = 0,006) y disminución de HDL-c (RP = 1,002; IC95%: 1,00-1,00; p < 0,001) estuvieron asociadas con la ingesta de colesterol en la dieta. La mayoría de los niños tuvieron al menos un cambio en los lípidos séricos. Las anomalías del perfil lipídico se asociaron con un mayor IMC, mayor edad y mayor consumo de calorías y colesterol.

This study aimed to assess the prevalence and factors associated with lipid profile abnormalities of children aged 6 to 42 months in a Central-West Brazilian capital city. This cross-sectional study used data from the baseline of a cluster-randomized clinical trial conducted in parallel. It evaluated the lipid profile, usual nutrients intake (direct food-weighing method and 24-hour dietary recall), anthropometric parameters, and socioeconomic aspects of 169 children from early childhood education centers. Poisson regression with robust variance analysis was conducted. Of the total sample, 85% had dyslipidemia, 72% had high-density lipoproteins (HDL-c) levels below the desired range, 49% had increased triglycerides (TG), 17% exhibited elevated low-density lipoproteins (LDL-c), and 15% showed high total cholesterol (TC). An increase in the body mass index (BMI) for age z-score was associated with a higher prevalence of increased TG (PR = 1.22; 95%CI: 1.05-1.41; p = 0.009). Higher age in children was associated with an increased prevalence of high LDL-c (PR = 1.037; 95%CI: 1.01-1.07; p = 0.022) and TC (PR = 1.036; 95%CI: 1.00-1.07; p = 0.037), however it was a protective factor against low HDL-c (PR = 0.991; 95%CI: 0.98-1.00; p = 0.042). High energy intake was associated with low HDL-c (PR = 1.001; 95%CI: 1.00-1.00; p = 0.023). A higher prevalence of increased LDL-c (PR = 1.005; 95%CI: 1.00-1.01; p = 0.006) and decreased HDL-c (PR = 1.002; 95%CI: 1.00-1.00; p < 0.001) were associated with dietary cholesterol intake. Most of the children presented at least one alteration in serum lipids. Lipid profile abnormalities were associated with higher BMI, older age, and increased caloric and cholesterol intake.

O objetivo deste estudo foi avaliar a prevalência e os fatores associados às anormalidades do perfil lipídico de crianças de 6 a 42 meses de idade em uma capital do Centro-oeste do Brasil. Este estudo transversal utilizou dados da linha de base de um ensaio clínico randomizado por conglomerados realizado em paralelo. Avaliou-se o perfil lipídico, a ingestão habitual de nutrientes (método de pesagem direta de alimentos e recordatório alimentar de 24 horas), parâmetros antropométricos e aspectos socioeconômicos de 169 crianças de centros de educação infantil. Foi realizada uma regressão de Poisson com análise de variância robusta. Da amostra total, 85% apresentavam dislipidemia, 72% tinham níveis de lipoproteínas de alta densidade (HDL-c) abaixo da faixa desejada, 49% tinham triglicerídeos (TG) aumentados, 17% apresentavam lipoproteínas de baixa densidade (LDL-c) elevadas e 15% apresentavam colesterol total (CT) elevado. Um aumento no índice de massa corporal (IMC) para o escore z da idade foi associado a uma maior prevalência de aumento de TG (RP = 1,22; IC95%: 1,05-1,41; p = 0,009). A idade mais avançada das crianças foi associada a uma maior prevalência de LDL-c alto (RP = 1,037; IC95%: 1,01-1,07; p = 0,022) e CT (RP = 1,036; IC95%: 1,00-1,07; p = 0,037), mas foi um fator de proteção contra HDL-c baixo (RP = 0,991; IC95%: 0,98-1,00; p = 0,042). A alta ingestão de energia foi associada ao baixo HDL-c (RP = 1,001; IC95%: 1,00-1,00; p = 0,023). Uma maior prevalência de aumento de LDL-c (RP = 1,005; IC95%: 1,00-1,01; p = 0,006) e diminuição de HDL-c (RP = 1,002; IC95%: 1,00-1,00; p < 0,001) foi associada à ingestão de colesterol na dieta. A maioria das crianças apresentou pelo menos uma alteração nos lipídios séricos. As anormalidades do perfil lipídico foram associadas ao IMC mais alto, à idade mais avançada e ao aumento da ingestão calórica e de colesterol.

https://doi.org/10.1590/0102-311xen202123

11.

Hand tumors
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Neder Filho, Antonio Tufi

; Costa, Antonio Carlos da

; Barros, Rui Sérgio Monteiro de

; Nakachima, Luis Renato

; Rodrigues, Mauricio Pinto

; Souza, Sandro Castro Adeodato de

; Oliveira, Ricardo Kaempf de

; Gama, Sérgio Augusto Machado da

; Sabongi, Rodrigo Guerra

; Hirakawa, Celso Kiyoshi

Revista da Associação Médica Brasileira

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2024, Volume 70 Suppl. 1 elocation e2024S108

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2024s108

12.

Diretrizes da Sociedade Brasileira de Angiologia e de Cirurgia Vascular sobre o pé diabético 2023 202 20 2
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Duarte Junior, Eliud Garcia

; Lopes, Cicero Fidelis

; Gaio, Danilo Roberto Fadel

; Mariúba, Jamil Victor de Oliveira

; Cerqueira, Lorena de Oliveira

; Manhanelli Filho, Marcos Antonio Bonacorso

; Navarro, Tulio Pinho

; Castro, Aldemar Araújo

; Araujo, Walter Jr. Boim de

; Pedrosa, Hermelinda

; Galli Filho, Júnio

; Luccia, Nelson de

; Paula, Clayton de

; Reis Neto, Fernando

; Bohatch Júnior, Milton Sérgio

; Oliveira, Tércio Ferreira de

; Silva, Amanda Fernandes Vidal da

; Oliveira, Júlio Cesar Peclat de

; Joviliano, Edwaldo Édner

Jornal Vascular Brasileiro

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2024, Volume 23 elocation e20230087

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo O pé diabético corresponde a uma interação entre fatores anatômicos, vasculares e neurológicos que representam um desafio na prática clínica. O objetivo deste trabalho foi compilar as principais evidências científicas com base em uma revisão das principais diretrizes, além de artigos publicados nas plataformas Embase, Lilacs e PubMed. O sistema da Sociedade Européia de Cardiologia foi utilizado para desenvolver classes de recomendação e níveis de evidência. Os temas foram divididos em seis capítulos (Capítulo 1-Prevenção de úlceras nos pés de pessoas com diabetes; Capítulo 2-Alívio da pressão de úlceras nos pés de pessoas com diabetes; Capítulo 3-Classificações das úlceras do pé diabético; Capítulo 4-Pé diabético e a doença arterial periférica; Capítulo 5-Infecção e o pé diabético; Capítulo 6-Neuroartropatia de Charcot). A versão atual das Diretrizes sobre pé diabético apresenta importantes recomendações para prevenção, diagnóstico, tratamento e seguimento dos pacientes com pé diabético, oferecendo um guia objetivo para prática médica. anatômicos clínica diretrizes Embase PubMed evidência 1Prevenção Prevenção 1 diabetes 2Alívio Alívio 2 3Classificações Classificações 3 4Pé Pé 4 periférica 5Infecção Infecção 5 6Neuroartropatia Neuroartropatia 6 Charcot. Charcot . Charcot) prevenção diagnóstico médica

Abstract The diabetic foot interacts with anatomical, vascular, and neurological factors that challenge clinical practice. This study aimed to compile the primary scientific evidence based on a review of the main guidelines, in addition to articles published on the Embase, Lilacs, and PubMed platforms. The European Society of Cardiology system was used to develop recommendation classes and levels of evidence. The themes were divided into six chapters (Chapter 1 - Prevention of foot ulcers in people with diabetes; Chapter 2 - Pressure relief from foot ulcers in people with diabetes; Chapter 3 -Classifications of diabetic foot ulcers; Chapter 4 - Foot and peripheral artery disease; Chapter 5 - Infection and the diabetic foot; Chapter 6 - Charcot's neuroarthropathy). This version of the Diabetic Foot Guidelines presents essential recommendations for the prevention, diagnosis, treatment, and follow-up of patients with diabetic foot, offering an objective guide for medical practice. anatomical vascular practice guidelines Embase Lilacs platforms diabetes Classifications disease Charcots Charcot s neuroarthropathy. neuroarthropathy . neuroarthropathy) prevention diagnosis treatment followup follow up

https://doi.org/10.1590/1677-5449.202300871

13.

Coleoptera of Brazil: what we knew then and what we know now. Insights from the Catálogo Taxonômico da Fauna do Brasil Brazil now
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Caron, Edilson

; Monné, Marcela L.

; Ferreira, Vinicius S.

; Costa, Cleide

; Cupello, Mario

; Aloquio, Sergio

; Linzmeier, Adelita M.

; Vaz-de-Mello, Fernando Z.

; Leivas, Fernando W.T.

; Souza-Gonçalves, Igor

; Mermudes, José R.M.

; Almeida, Lúcia M.

; Moura, Luciano de A.

; Ferreira Júnior, Nelson

; Grossi, Paschoal C.

; Vanin, Sergio A.

; Ślipiński, Adam

; Anichtchenko, Alexander

; Newton, Alfred F.

; Sampaio, Aline

; Carelli, Allan

; Puker, Anderson

; Ferreira, André da S.

; Fernandes, André S.

; Roza, André S.

; Cline, Andrew

; Sampaio, Brunno H.L.

; Clarkson, Bruno

; Castro, Camila F. de

; Bicho, Carla de L.

; Benetti, César J.

; Ribeiro-Costa, Cibele S.

; Lopes-Andrade, Cristiano

; Manfio, Daiara

; Colpani, Daniara

; Basílio, Daniel S.

; Bená, Daniela de C.

; Pollock, Darren A.

; Souza, Diego de S.

; Rodrigues, Diego F.

; Chandler, Donald S.

; Nascimento, Elynton A. do

; Spiessberger, Erich L.

; Agrain, Federico A.

; Barbosa, Felipe F.

; Shockley, Floyd

; Nascimento, Francisco E. de L.

; Biffi, Gabriel

; Powell, Gareth S.

; Morse, Geoffrey E.

; Flores, Gustavo E.

; Escalona, Hermes

; Quintino, Hingrid Y.S.

; Rainho, Hugo L.

; Maddalena, Italo S.C.P.

; Hájek, Jiří

; McHugh, Joseph V.

; Botero, Juan P.

; Fuhrmann, Juares

; Churata-Salcedo, Julissa M.

; Vieira, Letícia M.

; Silveira, Luiz F.L. da

; Cruz, Luiza S. da

; Sekerka, Lukás

; Bologna, Marco A.

; Bevilaqua, Marcus V.O.

; Passos, Maria I.

; Chamorro, Maria L.

; Cherman, Mariana A.

; Bento, Matheus

; Gimmel, Matthew

; Segura, Melissa O.

; Ivie, Michael A.

; Thomas, Michael C.

; Monné, Miguel A.

; Lord, Nathan

; Hamada, Neusa

; Degallier, Nicolas

; Santos, Paula B. dos

; Duarte, Paulo R.M.

; Gnaspini, Pedro

; Bulirsch, Petr

; Regalin, Renato

; Leschen, Richard A.B.

; Constantin, Robert

; Corrêa, Rodrigo C.

; Gerstmeier, Roland

; Rosa, Simone P.

; Campos, Stéphanie V.N.

; Peck, Stewart B.

; Pacheco, Thaynara L.

; Polizei, Thiago T.S.

; McElrath, Thomas C.

; Grzymala, Traci L.

; Smith, Trevor R.

; Costa-Silva, Vinicius da

; Sandoval-Gómez, Vivian E.

; Sousa, Wesley O. de

; Tomaszewska, Wioletta

Zoologia (Curitiba)

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2024, Volume 41 elocation e23072

Abstract: En | Text: En | PDF: En

ABSTRACT In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, including representatives of all extant suborders and superfamilies. Our data show that the Brazilian beetle fauna is the richest on the planet, concentrating 9% of the world species diversity, with some estimates accounting to up to 15% of the global total. The most diverse family in numbers of genera is Cerambycidae (1,056 genera), while in number of species it is Chrysomelidae (6,079 species). Conotrachelus Dejean, 1835 (Curculionidae) is the most species-rich genus, with 570 species. The French entomologist Maurice Pic is the author who has contributed the most to the naming of species recorded from Brazil, with 1,794 valid names in 36 families, whereas the Brazilians Ubirajara R. Martins and Maria Helena M. Galileo are the only ones among the top-ten authors to have named species in the 21st century. Currently, approximately 144 new species of Brazilian beetles are described each year, and this average is projected to increase in the next decade to 180 species per year, or about one new Brazilian beetle every two days. 2000 ra Twentyfour Twenty four later CTFB Brasil 10 globe Costas s Brazil 35699 35 699 35,69 4958 4 958 4,95 11 country superfamilies planet 9 diversity 15 total 1,056 1056 1 056 (1,05 genera, , genera) 6,079 6079 6 079 (6,07 . species) Dejean 183 Curculionidae (Curculionidae speciesrich rich genus 57 1794 794 1,79 3 R M topten top ten st century Currently 14 year 18 days 200 3569 69 35,6 495 95 4,9 1,05 105 05 (1,0 6,07 607 07 (6,0 5 179 79 1,7 20 356 35, 49 4, 1,0 0 (1, 6,0 60 (6, 17 7 1, 2 (1 6, (6 (

https://doi.org/10.1590/s1984-4689.v41.e23072

14.

Modeling and optimization of enzymatic and fermentation reactions in the production process of a symbiotic fermented milk beverage
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Téllez, Sergio

; Amaya, Yury

; Castro, Germán

; Noriega, Mario

; Serrato, Juan C.

Brazilian Journal of Food Technology

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2024, Volume 27 elocation e2023129

Abstract: En | Text: En | PDF: En

Abstract Symbiotic fermented kinds of milk are products with probiotic microorganisms and a simultaneous prebiotic effect. The presence of fibers or oligosaccharides causes it. This work aimed to evaluate and model fermented milk beverage production with probiotic microorganisms and in situ Galactooligosaccharides (GOS) synthesis. GOS enzymatic production was maximized through the mathematical model, and finally, the mathematical prediction was experimentally validated. For this purpose, the enzymatic kinetics of GOS production from Aspergillus oryzae β-galactosidase enzyme was experimentally evaluated for different initial lactose concentrations (30%, 35%, and 40% w/v) and enzyme/lactose ratio (R: 0.2%, 0.4%, and 0.6%). In addition, the fermentative kinetics of lactic acid and biomass production were evaluated using the probiotic strain Lactobacillus acidophilus. The parameters correlation for both models was then performed. A unified model determined the process conditions that maximize GOS concentration in the fermented milk beverage. According to the model, the operating values that maximized the GOS production were 40% of initial lactose, R: 0.15%, 20 min of enzymatic reaction, and 17 h of fermentative reaction. The final fermented milk drink showed a GOS content of 2.9 g/portion of 200 g, guaranteeing the recommended daily values of the prebiotic with the consumption of two servings. effect it (GOS synthesis finally validated purpose βgalactosidase β galactosidase 30%, 30 (30% 35 35% 40 w/v wv w v enzymelactose R (R 02 0 2 0.2% 04 4 0.4% 0.6%. 06 0.6% . 6 0.6%) addition acidophilus performed 015 15 0.15% reaction 1 29 9 2. gportion g portion servings 30% 3 (30 0.2 0.4 0.6 01 0.15 (3 0. 0.1 (

https://doi.org/10.1590/1981-6723.12923

15.

Three-Dimensional Volumetric Investigation of Onodi Cells: A Multi-Slice Computed Tomography Study ThreeDimensional Three Dimensional Cells MultiSlice Multi Slice
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Dieguez, Flavia Limberg

; Rosa, Catharina Simioni De

; Braz-Silva, Paulo Henrique

; Lopes, Sergio Lucio Pereira de Castro

; Costa, Andre Luiz Ferreira

International Archives of Otorhinolaryngology

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2024, Volume 28 N. 2 Pages 196 - 202

Abstract: En | Text: En | PDF: En

Abstract Introduction Onodi cells (OCs) are posterior ethmoid cells that are located above the sphenoid sinus, close to or even surrounding the carotid artery and optic nerve. Objective To investigate and evaluate the volumetric variation of OCs through multi-slice computed tomography (MSCT) scans. Methods We performed a retrospective review of MSCT scans of 79 subjects, 40 male and 39 female patients, Whose age ranged from 18 to 83 (mean: 39.6) years. The volumes of the OCs on the right and left sides were measured using the ITK-SNAP software (open-source) with semiautomatic segmentation. The possible relationships involving age, gender, contact with the optic nerve, extension of the pneumatization of the posterior ethmoid cells into the clinoid processes, mucous thickening in the anterior and posterior ethmoid cells, and obliteration of the sphenoethmoidal complex were analyzed with the Pearson correlation and Chi-squared tests according to the type of data compared and logistic regression models (p < 0.05). Results We observed that an increase of one unit in the volume of OCs also increases the chance of extension of pneumatization into the clinoid processes by 0.15% (p = 0.001). No significant correlations were identified regarding age, gender, and volume of the OCs. Conclusion The volume of the OCs has effects on the extension of pneumatization into the clinoid processes. (OCs sinus nerve multislice multi slice (MSCT 7 subjects 4 3 patients 1 8 mean (mean 39.6 396 6 years ITKSNAP ITK SNAP opensource open source (open-source segmentation gender Chisquared Chi squared p 0.05. 005 0.05 . 0 05 0.05) 015 15 0.15 0.001. 0001 0.001 001 0.001) 39. 00 0.0 01 0.1 000 0.00 0.

https://doi.org/10.1055/s-0043-1773762

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