Resumo Fundamento Não existem estudos randomizados comparando a manutenção do ritmo sinusal após ablação por cateter (AC) em relação ao tratamento com fármacos antiarrítmicos (AA) em pacientes idosos portadores fibrilação atrial (FA) paroxística. Objetivos Comparar os resultados clínicos do isolamento das veias pulmonares (VPs) com o cateter PVAC Gold de segunda geração com o uso de AA em idosos com FA paroxística sintomática, recorrente, apesar do uso de fármacos AA. Métodos Sessenta pacientes com FA paroxística ≥ 65 anos e sem cardiopatias estruturais foram randomizados para duas formas de tratamento: grupo 1: AC e grupo 2: AA. O desfecho primário foi a taxa livre de recorrência de FA após pelo menos um ano de seguimento. Os desfechos secundários foram: progressão para formas persistentes de FA, impacto na qualidade de vida (QVFA) e complicações. O nível de significância adotado na análise estatística foi de 5% (p<0,05). Resultados A taxa livre de recorrência de FA foi de 80% (10% com amiodarona) no grupo AC, após 1,3 procedimentos por paciente e de 65% no grupo AA (60% com amiodarona), (p = 0,119) num seguimento médio de 719 dias (Q1: 566; Q3: 730). A taxa livre de FA persistente foi de 83,4% no grupo AC e de 67,7% no grupo AA (p = 0,073). Ambas as estratégias apresentaram melhora no escore de QVFA durante o seguimento (p < 0,001), sem diferença entre os grupos. Embora sem repercussão clínica ou impacto no teste de avaliação intelectual, 25% dos pacientes do grupo PVAC apresentou sinais de embolização cerebral na RNM cerebral. Conclusões Ambas as estratégias para manutenção do ritmo sinusal promoveram melhora na qualidade de vida de pacientes idosos com FA sintomática, sem diferença estatística nos desfechos clínicos preconizados. Estudos adicionais usando tecnologias com melhor perfil de segurança são necessários para avaliar os benefícios da AC em pacientes idosos com FA. (AC (AA (FA VPs (VPs sintomática recorrente 6 1 2 (QVFA complicações 5 p<0,05. p005 p p<0,05 . 0 05 (p<0,05) 80 10% 10 (10 amiodarona 13 3 1, 60% 60 (60 amiodarona, , 0,119 0119 119 71 Q1 Q (Q1 566 Q3 730. 730 730) 834 83 4 83,4 677 67 7 67,7 0,073. 0073 0,073 073 0,073) 0,001, 0001 0,001 001 0,001) grupos intelectual 25 preconizados p00 p<0,0 (p<0,05 8 (1 (6 0,11 011 11 (Q 56 73 83, 67, 007 0,07 07 000 0,00 00 p0 p<0, (p<0,0 ( 0,1 01 0,0 p<0 (p<0, 0, p< (p<0 (p<

Abstract Background There are no randomized studies comparing the maintenance of sinus rhythm after catheter ablation (CA) concerning treatment with antiarrhythmic drugs (AA) in elderly patients with paroxysmal atrial fibrillation (AF). Objectives To compare the clinical results of pulmonary vein (PV) isolation with the second-generation PVAC Gold catheter against AA treatment in elderly people with recurrent symptomatic paroxysmal AF, refractory to at least one AA, and without structural heart disease. Methods Sixty patients with paroxysmal AF ≥ 65 years old were randomized to two forms of treatment: group 1: CA and group 2: AA drugs. The primary outcome was the AF recurrence-free rate after at least one year of follow-up. Secondary outcomes were: progression to persistent forms of AF, impact on quality of life (QOLF), and complications. The significance level adopted in the statistical analysis was 5% (p<0.05). Results The AF recurrence-free rate was 80% (10% with amiodarone) in the CA group, after 1.3 procedures per patient and 65% in the AA group (60% with amiodarone), (p = 0.119) in an average follow-up of 719 days (Q1: 566; Q3: 730). The persistent AF free rate was 83.4% in the AC group and 67.7% in the AA group (p = 0.073) Both strategies showed an improvement in the AFQoL score during follow-up (p < 0.001), with no difference between the groups. Although without clinical repercussions or impact on the intellectual assessment test, 25% of patients in the CA group showed signs of cerebral embolization on brain MRI. Conclusions Both strategies for maintaining sinus rhythm promoted an improvement in the quality of life of elderly patients with symptomatic AF, with no statistical difference in the clinical outcomes. Additional studies using technologies with a better safety profile are needed to evaluate the benefits of CA in elderly patients with AF. (CA (AA . (AF) PV (PV secondgeneration second generation disease 6 1 2 recurrencefree recurrence followup. followup follow up. up QOLF, QOLF , (QOLF) complications 5 p<0.05. p005 p p<0.05 0 05 (p<0.05) 80 10% 10 (10 amiodarone 13 3 1. 60% 60 (60 amiodarone, 0.119 0119 119 71 Q1 Q (Q1 566 Q3 730. 730 730) 834 83 4 83.4 677 67 7 67.7 0.073 0073 073 0.001, 0001 0.001 001 0.001) groups test 25 MRI (AF (QOLF p00 p<0.0 (p<0.05 8 (1 (6 0.11 011 11 (Q 56 73 83. 67. 0.07 007 07 000 0.00 00 p0 p<0. (p<0.0 ( 0.1 01 0.0 p<0 (p<0. 0. p< (p<0 (p<

RESUMO Conhecer a distribuição e o padrão espacial de espécies dentro de uma comunidade vegetal é imprescindível para o planejamento de estratégias de conservação e estabelecer medidas de manejo sustentável em formações florestais, sobretudo em áreas de Caatinga. Nesse sentido, o objetivo do estudo foi analisar a estrutura e a distribuição espacial de Pilosocereus pachycladus F. Ritter subsp. pernambucoensis (F. Ritter) em populações naturais em áreas de Caatinga e de Brejo no Semiárido Paraibano, nos municípios de Bananeiras e Arara, respectivamente. Nas áreas de estudo, foram demarcadas 25 parcelas de 20 m x 20 m, totalizando uma área amostral de 10.000m2 (1 ha). Dentro das parcelas, todos os indivíduos foram etiquetados e a altura total e a circunferência foram auferidas ao nível da base do caule com auxílio de uma fita métrica. A estrutura espacial das populações foi obtida pela coleta da coordenada geográfica de cada indivíduo em cada área e expressa por meio de mapas de distribuição espacial. Foram amostrados 61 espécimes na Caatinga do município de Bananeiras, apresentando densidade absoluta de 61 ind.ha-1 e frequência absoluta (FA) de 52%. Foram amostrados 64 espécimes no bioma do município de Arara, apresentando densidade absoluta de 64 ind.ha-1 e frequência absoluta (FA) de 56%. As duas populações estavam dispostas em padrão de agrupamento (Pi = 3,74 e 3,47, respectivamente). Os indivíduos de P. pachycladus subsp. pernambucoensis das duas áreas possuem hábito de crescimento agregado e estrutura populacional com poucos indivíduos regenerantes. As ações regionais de conservação das espécies de Cactaceae em seu habitat precisam levar em consideração essas descobertas para garantir a sobrevivência dessas espécies. florestais sentido F subsp (F Paraibano Arara respectivamente 2 10000m2 10 000m2 10.000m 1 ( ha. ha . ha) métrica 6 ind.ha1 indha1 indha ind.ha ind ind.ha- FA (FA 52 52% 56 56% Pi 374 3 74 3,7 347 47 3,47 respectivamente) P regenerantes 10000m 000m ha1 5 37 7 3, 34 4 3,4

ABSTRACT Knowing the distribution and spatial pattern of species within a plant community is essential for planning conservation strategies and establishing sustainable management measures in forest formations, especially in Caatinga areas. In this sense, the aim of the study was to analyze the structure and spatial distribution of Pilosocereus pachycladus F. Ritter subsp. pernambucoensis (F. Ritter) in natural populations in areas of Caatinga and Brejo vegetation in the semi-arid region of Paraíba, in the municipalities of Bananeiras and Arara, respectively. In the study areas, 25 plots of 20 m x 20 m were demarcated, totaling a sample area of 10,000 m2 (1 ha). Within the plots, all individuals were labeled and the total height and circumference were measured at the base of the stem using a measuring tape. The spatial structure of the populations was obtained by collecting the geographic coordinate of each individual in each area and expressed through maps of spatial distribution. 61 specimens were sampled in the Caatinga of Bananeiras, with an absolute density of 61 ind.ha-1 and absolute frequency (FA) of 52%. 64 specimens were sampled in the Caatinga of Arara, with an absolute density of 64 ind.ha-1 and absolute frequency (FA) of 56%. The two populations were arranged in a cluster pattern (Pi = 3.74 and 3.47, respectively). P. pachycladus subsp. pernambucoensis of the two areas have a habit of aggregate growth and population structure with few regenerating individuals. Regional conservation actions for Cactaceae species in their habitat need to take these findings into account to ensure the survival of these species. formations sense F subsp (F semiarid semi arid Paraíba Arara respectively 2 demarcated 10000 10 000 10,00 1 ( ha. ha . ha) tape 6 ind.ha1 indha1 indha ind.ha ind ind.ha- FA (FA 52 52% 56 56% Pi 374 3 74 3.7 347 47 3.47 respectively) P 1000 00 10,0 ha1 5 37 7 3. 34 4 3.4 100 0 10,

The composition of human milk (HM) includes changes under the influence of factors such as genetics, stage of lactation, time of day, and even breastfeeding time. However, the authors are not aware of studies that evaluated the influence of breastfeeding time on fatty acid composition and cytokine. Thus, the objective of this study was to evaluate the influence of breastfeeding time (previous, intermediate, posterior milk) on kilocalorie concentration, fatty acid (FA) composition, and concentration of the cytokines interleukin-10 (IL-10), interferon factors for necrotic tumor (TNF-α) in HM colostrum. The results showed that the concentration of kilocalories was higher in posterior milk than in the previous, the composition of the main fatty acids found in the samples was influenced by the breastfeeding time, and the concentration of IL-10 and TNF-α was influenced in all samples with exception to mother 2. The principal component analysis explained 71% of the variances in the results. Thus, we concluded that the breastfeeding time is a factor that influences the concentration of kilocalories, and if it is necessary to use a more caloric milk, it is recommended to use the posterior milk; the FAs composition and the evaluated cytokines were also influenced by the breastfeeding time. (HM genetics lactation day However cytokine Thus previous (previous intermediate FA (FA interleukin10 interleukin 10 interleukin-1 IL10, IL10 IL , (IL-10) TNFα TNF α (TNF-α colostrum IL-1 2 71 interleukin1 1 interleukin- IL1 (IL-10 IL- 7 (IL-1 (IL- (IL

SUMMARY Friedreich Ataxia (FA) is an autosomal recessive neurodegenerative disease with multisystemic involvement. This update of epidemiological, pathophysiological, and clinico-therapeutic aspects of FA, includes a systematic review of cases in Latin America. The estimated FA prevalence in Caucasian populations is between 2 to 5 cases per 100 000. In Latin America, 1481 cases have been published in 35 articles from six different countries. Caused by an abnormally repeated expansion of GAA trinucleotide inside the FXN gene, FA’s etiopathogenesis is associated with reduced levels of the frataxin protein, which disturb the energy metabolism and result in mitochondrial iron accumulation. The classic phenotype usually shows symptoms before the age of 25, although there are others with a later onset. The main symptoms of AF are progressive ataxia, sensory disturbances, areflexia, dysarthria, and oculomotor alterations, in addition to cardiac, endocrine, and musculoskeletal compromise. Diagnostic workup requires a detailed neurological examination, neuroconduction studies, neuroimaging, and biochemical tests. The definitive diagnosis is provided by genetic testing showing biallelic variants within the FXN gene. The management is multidisciplinary, aimed at reducing symptoms, preventing complications, and providing an appropriate genetic counseling. Recently, the first pharmacological treatment for AF has been approved, with several others in clinical assessment trials.

RESUMEN La Ataxia de Friedreich (AF) es una enfermedad neurodegenerativa autosómica recesiva con compromiso multisistémico. En esta revisión, se actualizan aspectos epidemiológicos, fisiopatológicos y clínico-terapéuticos y se conduce una búsqueda sistemática de casos de AF reportados en Latinoamérica. La prevalencia de AF en poblaciones caucásicas es estimada entre 2 y 5 casos por 100 000 habitantes. En Latinoamérica se han publicado 35 estudios que reúnen 1481 casos en 6 países. Causada por la expansión anormal de repeticiones GAA en el gen FXN, la etiopatogenia está asociada a una reducción en los niveles de la proteína frataxina (que altera el metabolismo energético) y el acúmulo de hierro mitocondrial. El fenotipo clásico de AF suele comenzar antes de los 25 años, aunque hay otros de inicio tardío y retención de reflejos. La sintomatología se caracteriza por ataxia progresiva, alteración sensitiva, arreflexia, disartria, y alteraciones oculomotoras, además de compromiso cardiaco, endocrino y musculoesquelético. El diagnóstico requiere evaluación neurológica detallada, estudios neurofisiológicos, neuroimágenes y pruebas bioquímicas pero el enfoque determinante es el estudio genético que demuestre variantes genéticas bialélicas en el gen FXN. El manejo es multidisciplinario, orientado a aminorar los síntomas, prevenir complicaciones y brindar asesoramiento genético apropiado. Recientemente se ha aprobado el primer tratamiento farmacológico para AF con varios más en fases de experimentación.

RESUMO: Os objetivos foram analisar as informações genealógicas de bovinos Gir (GY) e Nelore (NL) da Costa Rica. Foram considerados: integridade do pedigree (GY, 13272; NL, 18153); número de gerações completas, máximas traçadas e equivalentes completas; endogamia (FI); intervalo de geração (GI) por meio de quatro rotas de seleção; razão genética aditiva média (AGR); número efetivo de fundadores (fe); número efetivo de ancestrais (fa); tamanho efetivo da população (Ne). A análise foi realizada com o software ENDOG. A proporção máxima de pais, avós e bisavós desconhecidos foi de 18,6%, 39,9% e 59,3%, respectivamente. O FI médio para NL foi de 8,87% e 2,85% no GY. A média da população consanguínea (%) e FI foi de 53,9 e 16,5% em NL, 28,9 e 9,9% em GY. Os valores médios e máximos de AGR para NL foram 3,5 e 12,8, 1,4 e 5,6 no GY. Os fe e fa para NL foram 65,0 e 38,0, no GY 145,7 e 59,0. O Ne indicou aumentos de FI na faixa de 1 a 2% no GY, para NL superiores a 2%, com status de cuidado para acompanhar a evolução de F e AGR e suas possíveis implicações no melhoramento genético. O IG variou de 6,3 a 7,9 anos com média geral de 6,9 anos. Esses resultados mostram um resumo do manejo genético e reprodutivo realizado por esses criadores. RESUMO (GY (NL Rica considerados 13272 18153 18153) completas (FI) GI (GI seleção (AGR) (fe) (fa) Ne. . (Ne) ENDOG pais 186 18 6 18,6% 399 39 9 39,9 593 59 3 59,3% respectivamente 887 8 87 8,87 285 2 85 2,85 % (% 539 53 53, 165 16 5 16,5 289 28 28, 99 9,9 35 3, 128 12 12,8 14 4 1, 56 5, 650 65 0 65, 380 38 38,0 1457 145 7 145, 590 59,0 63 6, 79 7, 69 criadores 1327 1815 (FI (AGR (fe (fa (Ne 18,6 39, 59,3 88 8,8 2,8 ( 16, 9, 12, 38, 59, 132 181 18, 8, 2, 13

ABSTRACT: The objectives were to analyze the genealogical information of Gyr (GY) and Nelore (NL) cattle from Costa Rica. Analyzed: pedigree integrity (GY, 13272; NL, 18153); number of complete, maximum traced and equivalent complete generations; inbreeding (FI); generation interval (GI) through four selection routes; average additive genetic ratio (AGR); effective number of founders (fe); effective number of ancestors (fa); effective population size (Ne). The analysis was performed with the ENDOG software. The maximum proportion of unknown parents, grandparents, and great-grandparents was 18.6%, 39.9%, and 59.3%, respectively. The average FI for NL was 8.87% and 2.85% in GY. The average consanguineous population (%) and FI was 53.9 and 16.5% in NL, 28.9 and 9.9% in GY. The average and maximum values of AGR for NL were 3.5 and 12.8, 1.4 and 5.6 in GY. The fe and fa for NL were 65.0 and 38.0, in GY 145.7 and 59.0. The Ne indicated increases in FI in the range of 1 to 2% in GY, for NL greater than 2%, with a status of care to monitor the evolution of F and AGR and their possible implications in genetic improvement. The GI ranged from 6.3 to 7.9 years with a general average of 6.9 years. These results show a summary of the genetic and reproductive management those breeders have carried out. ABSTRACT (GY (NL Rica Analyzed 13272 18153 18153) generations (FI) (GI routes (AGR) (fe) (fa) Ne. . (Ne) software parents grandparents greatgrandparents great 186 18 6 18.6% 399 39 9 39.9% 593 59 3 59.3% respectively 887 8 87 8.87 285 2 85 2.85 % (% 539 53 53. 165 16 5 16.5 289 28 28. 99 9.9 35 3. 128 12 12.8 14 4 1. 56 5. 650 65 0 65. 380 38 38.0 1457 145 7 145. 590 59.0 improvement 63 6. 79 7. 69 out 1327 1815 (FI (AGR (fe (fa (Ne 18.6 39.9 59.3 88 8.8 2.8 ( 16. 9. 12. 38. 59. 132 181 18. 39. 8. 2. 13

ABSTRACT Objective: The aim of this study was compared and correlate kinematics and physiological parameters in four maximal swimming tests of two groups of young swimmers. Methods: Twelve swimmers, separated in two groups by age (percentile > 50th (n = 6): 15.4 ± 1.11 years old as group 1, and < 50th (n = 6): 12.1 ± 0.83 as group 2) performed four tests during two different sessions. They performed front crawl trials at maximum intensity: 50 and 200 meters on first day and 100 and 400 m meters on second day. Anthropometric characteristics were measured. Stroke rate, stroke length, stroke index, swimming speed and critical speed were obtained by video analysis. Moreover, were measured the blood lactate concentration, heart rate and rate of perceived exertion. Results: There are no differences at anthropometric characteristics. We found difference between group 1 and group 2. Better results for performance, swimming speed, stroke length and stroke index in group 1. Swimming speed and stroke index show strong correlation in all tests for group 1 and in 50 and 100 meters for group 2. To measure the swimmer profile is essential to verify the benefits that the training program is or is not providing. Conclusion: The parameters evaluated seem related to age and capacities of the swimmers.

RESUMO Objetivo: fístula anastomótica (FA) após colectomia para câncer colorretal (CCR) é complicação grave. Esta revisão sistemática e meta-análise avaliou os fatores de risco pré-operatórios para FA em pacientes submetidos à colectomia. Métodos: a pesquisa bibliográfica abrangeu 15 anos e 9 meses (1 de janeiro de 2005 - 19 de outubro de 2020), sendo utilizadas as plataformas PubMed, Cochrane Library, Scopus, Biblioteca Virtual em Saúde, Europe PMC e Web of Science. O critério de inclusão foram estudos transversais, coorte e caso-controle em fatores de risco pré-operatórios para FA (desfecho). A escala Newcastle-Ottawa foi usada para avaliação de viés dos estudos. A metanálise envolveu o cálculo dos efeitos de tratamento para cada estudo individualmente incluindo odds ratio (OR), risco relativo (RR) e intervalo de confiança de 95% (IC95%) com construção de modelo de efeitos aleatórios, para avaliar o impacto de cada variável (p<0,05). Resultados: foram selecionados 39 estudos transversais, 21 coortes e quatro casos-controle. A metanálise identificou 14 fatores de risco para FA em pacientes com CCR após colectomia, que são sexo masculino (RR=1,56; IC 95%=1,40-1,75), tabagismo (RR=1,48; IC 95%=1,30-1,69), alcoolismo (RR=1,35; IC 95%=1,21-1,52), diabetes mellitus (RR=1,97; IC 95%=1,44-2,70), doenças pulmonares (RR=2,14; IC 95%=1,21-3,78), doença pulmonar obstrutiva crônica (RR=1,10; IC 95%=1,04-1,16), doença coronariana (RR=1,61; IC 95%=1,07-2,41), doença renal crônica (RR=1,34; IC 95%=1,22-1,47), altas notas na escala ASA (RR=1,70; IC 95%=1,37-2,09), cirurgia abdominal prévia (RR=1,30; IC 95%=1,04-1,64), cirurgia de emergência (RR=1,61; IC 95%=1,26-2,07), quimioterapia neoadjuvante (RR=2,16; IC 95%=1,17-4,02), radioterapia (RR=2,36; IC 95%=1,33-4,19) e quimiorradioterapia (RR=1,58; IC 95%=1,06-2,35). Conclusões: importantes fatores de risco pré-operatórios para FA colorretais em pacientes com CCR foram identificados com base nas melhores pesquisas baseadas em evidências e esse conhecimento deve influenciar decisões relacionadas ao tratamento.

ABSTRACT Introduction: anastomotic leak (AL) after colectomy for colorectal cancer (CRC) is a life-threatening complication. This systematic review and meta-analysis aimed to evaluate the preoperative risk factors for AL in patients submitted to colectomy. Methods: the bibliographic search covered 15 years and 9 months, from 1st January 2005 to 19th October 2020 and was performed using PubMed, Cochrane Library, Scopus, Biblioteca Virtual em Saúde, Europe PMC and Web of Science databases. The inclusion criteria were cross-sectional, cohort and case-control studies on preoperative risk factors for AL (outcome). The Newcastle-Ottawa scale was used for bias assessment within studies. Meta-analysis involved the calculation of treatment effects for each individual study including odds ratio (OR), relative risk (RR) and 95% confidence intervals (95% CI) with construction of a random-effects model to evaluate the impact of each variable on the outcome. Statistical significance was set at p<0.05. Results: cross-sectional studies were represented by 39 articles, cohort studies by 21 articles and case-control by 4 articles. Meta-analysis identified 14 main risk factors for AL in CRC patients after colectomy, namely male sex (RR=1.56; 95% CI=1.40-1.75), smoking (RR=1.48; 95% CI=1.30-1.69), alcohol consumption (RR=1.35; 95% CI=1.21-1.52), diabetes mellitus (RR=1.97; 95% CI=1.44-2.70), lung diseases (RR=2.14; 95% CI=1.21-3.78), chronic obstructive pulmonary disease (RR=1.10; 95% IC=1.04-1.16), coronary artery disease (RR=1.61; 95% CI=1.07-2.41), chronic kidney disease (RR=1.34; 95% CI=1.22-1.47), high ASA grades (RR=1.70; 95% CI=1.37-2.09), previous abdominal surgery (RR=1.30; 95% CI=1.04-1.64), CRC-related emergency surgery (RR=1.61; 95% CI=1.26-2.07), neoadjuvant chemotherapy (RR=2.16; 95% CI=1.17-4.02), radiotherapy (RR=2.36; 95% CI=1.33-4.19) and chemoradiotherapy (RR=1.58; 95% CI=1.06-2.35). Conclusions: important preoperative risk factors for colorectal AL in CRC patients have been identified based on best evidence-based research, and such knowledge should influence decisions regarding treatment.

Resumen Introducción El uso de terapia anticoagulante en pacientes con miocardiopatía dilatada es controvertido. El riesgo hemorrágico hace que habitualmente no se use en pacientes en ritmo sinusal. Objetivo Analizar los factores predictores de fibrilación auricular (FA) en pacientes con miocardiopatía dilatada y fracción de eyección del ventrículo izquierdo (FEVI) < 40. Método: Se estudiaron los pacientes incluidos en el registro multicéntrico UMBRELLA a quienes se había implantado un desfibrilador (DAI) bicameral o tricameral y que presentaban miocardiopatía dilatada isquémica o no isquémica y FEVI < 40%. Se definió FA como cualquier episodio > 30 segundos de duración y una frecuencia auricular > 175 latidos por minuto. Resultados Se incluyeron 684 enfermos. La mediana de edad fue de 70 años (rango intercuartílico [RIQ]: 62-77). El 79.1% eran varones. La FEVI fue < 30% en el 76.3%. El 87.3% presentaban insuficiencia cardiaca (ICC) clínica. Se implantó un DAI resincronizador en el 59.5%. El 51.2% tenían bloqueo de rama izquierda del haz de His y el 7.1% de rama derecha (BRDHH). Se documentó FA en el 49% de los enfermos con una mediana de seguimiento de 29.93 meses (RIQ: 14.78-45.63). Las variables que se relacionaron con la aparición de FA fueron la presencia de ICC (hazard ratio [HR]: 2; intervalo de confianza del 95% [IC 95%]: 1.31-3.04; p = 0.001), el BRDHH (HR: 1.48; IC 95%: 1-2-18; p = 0.045), el ictus previo (HR: 2.11; IC 95%: 1.4-3.19; p < 0.001) y la edad > 75 años (HR: 1.21; IC 95%: 1.05-1.40; p = 0.008). Conclusiones La edad > 75 años, el BRDHH, la ICC y el ictus previo predicen la aparición de FA en la población con miocardiopatía dilatada y FEVI < 40%.

Abstract Introduction Anticoagulant treatment in patients with dilated cardiomyopathy and sinus rhythm is controversial due to haemorrhage risk. Objective To analyze the factors predicting atrial fibrillation (AF) in patients with dilated cardiomyopathy and ejection fraction (LVEF) < 40%. Method All patients included in UMBRELLA multicentre registry without AF, who had a dual or three-chamber implantable cardiac defibrillator (ICD), dilated cardiomyopathy and LVEF < 40% were included. AF was defined as any episode > 30 seconds of duration and atrial frequency > 175 bpm. Results 684 patients were included. Median age was 70 years (IQR 62-77); 79.1% were male. LVEF was < 30% in 76.3% of cases; 87.3% presented clinical heart failure (CHF). A CRT-D was implanted in 59.5%; 51.2% of patients presented Left Bundle Branch Block (LBBB) and 7.1% presented Right Bundle Branch Block (RBBB). AF was documented in 49% of patients, with a median follow-up of 29.93 months (IQR: 14.78-45.63). The presence of CHF (HR: 2; 95% CI: 1.31-3.04; p = 0.001), RBBB (HR: 1.48; 95% CI: 1-2-18; p = 0.045), previous stroke (HR: 2.11; 95% CI: 1.4-3.19; p < 0.001) and age > 75 years (HR: 1.21; 95% CI: 1.05-1.40; p = 0.008) were associated with diagnosis of AF. Conclusions Age > 75 years, RBBB, CHF and previous stroke are predictors of AF development in the population with dilated cardiomyopathy and LVEF < 40%.

The present work intends to obtain and characterize a milk by-product: the human whey (HW), in order to avoid the excessive disposal of human milk (HM). The characterization was performed through analyzes of the chemical composition and fatty acids (FAs) and the triacylglycerol (TAG) lipid profile. The results indicated that the chemical composition altered significantly after the HW obtained, except for the percentage of ash and carbohydrates. About the FA composition, it was observed that strictly essential FA, essential FA and other FAs found in HM remained present in HW. For the nutritional lipids quality, the atherogenicity and the thrombogenicity indices presented desirable values, and the TAGs lipid profile revealed a variation in the analyzed samples. Therefore, it can be concluded that the characterized HW has potential for application in isolated form or to be used as an ingredient in other foods.

ABSTRACT The objective of this study was to evaluate the population of Brahman cattle from Costa Rica. Pedigree analysis of 98,749 animals was used to estimate the following parameters: pedigree integrity, as a proportion of known ancestors; the number of complete generations, maximum generations traced, and equivalent complete generations; inbreeding coefficient (F); generation interval (GI) across four selection paths; additive genetic relationship (AGR); effective number of founders (fe) and ancestors (fa); and effective population size (Ne). The analysis was carried out using the ENDOG software. The maximum proportions of unknown parents, grandparents, and great-grandparents were 14.1%, 38.9%, and 61.2%, respectively. Average F for the whole population was 0.86, while 27.4% of the population was inbred, with an average F of 3.1%. The inbred population increased through the time, while F decreased. The average AGR was 0.64, with maximum values of 4.1 and positive trends. The fe and fa were 617.8 and 172.0, respectively. The Ne indicated increases of F, with values lower than 1%. The GI fluctuated from 6.4 to 7.4, with an average of 6.85 years. These results summarize previous breeding practices and represent useful information for designing breeding programs by anticipating the relationship between the selection response and increases of inbreeding.

Resumen El propósito del presente estudio fue examinar la efectividad del feedback aumentado (FA) en el desempeño y aprendizaje de destrezas motrices. La búsqueda de los estudios se realizó en bases de datos digitales, revisando referencias y consultando a personal experto del área. La selección de los estudios y la extracción de los datos fue realizada por las tres autoras de forma independiente. La calidad de los estudios se evaluó utilizando una modificación de la escala TESTEX. Con el modelo de efectos aleatorios se calculó el tamaño de efecto (TE) de la diferencia de medias estandarizada. Se examinó la heterogeneidad con la Q estadística y la consistencia con I 2 . Veinte estudios cumplieron los criterios de inclusión. Un total de 95 TE fueron calculados, lo cual representa a 949 participantes. El uso de FA durante la práctica física aumentó el desempeño significativamente entre el pretest y la adquisición (TE = 0.87; IC95% = 0.65, 1.10; n = 47; Q = 183.6, I 2 = 74.41%; p < 0.01); mientras que el desempeño disminuyó significativamente entre la prueba de adquisición y la retención, después de que el FA fue suspendido (TE = -0.74, IC95% = -1.04, -0.44; n = 45; Q = 377.45, I 2 . = 88.34%; p < 0.01). Se analizaron la edad y el nivel de habilidad de los sujetos participantes, el tipo de destreza y las características de la práctica y el tipo de FA como posibles variables moderadoras. Los resultados sugieren que el desempeño mejora en la adquisición al recibir FA durante la práctica física, y disminuye en la retención, una vez que no está disponible; no obstante, el uso de FA promueve significativamente el aprendizaje de destrezas motrices.

Resumo O objetivo do presente estudo foi examinar a eficácia do aumento do feedback (AF) sobre o desempenho e a aprendizagem das habilidades motoras. Foram pesquisados estudos em bancos de dados digitais, verificando referências e consultando especialistas na área. A seleção do estudo e a extração de dados foi feita pelos três autores independentemente. A qualidade dos estudos foi avaliada utilizando uma modificação da escala TESTEX. Sob o modelo de efeitos aleatórios, foi calculado o tamanho do efeito (TE) da diferença média padronizada. A heterogeneidade foi examinada usando o Q estatístico e a consistência usando o I2. Vinte estudos preencheram os critérios de inclusão. Um total de 95 TE's foi calculado, representando 949 participantes. O uso de AF durante a prática física aumentou significativamente o desempenho entre o pré-teste e a aquisição (ET = 0,87; CI95% = 0,65, 1,10; n = 47; Q = 183,6, I2 = 74,41%; p < 0. 01); enquanto o desempenho diminuiu significativamente entre o teste de aquisição e a retenção, depois que o AF foi suspenso (SD = -0,74, 95% CI = -1,04, -0,44; n = 45; Q = 377,45, I2. = 88,34%; p < 0,01). A idade e o nível de habilidade dos participantes, tipo de habilidade e características de prática, e tipo de AF foram analisados como possíveis variáveis moderadoras. Os resultados sugerem que o desempenho melhora na aquisição ao receber AF durante a prática física, e diminui na retenção, uma vez que ela não está disponível; entretanto, o uso de AF promove significativamente o aprendizado das habilidades motoras.

Abstract The purpose of this study was to use the meta-analytic approach to assess the effectiveness of augmented feedback (AF) on performance and learning of motor skills. Studies were retrieved by searching electronic databases, cross refereeing, and expert criteria. Studies were selected and data was extracted by the three authors independently. The quality of the studies was measured by a modify TEXTEX scale. Random effects models using the standardized mean difference effect size (ES) were used to pool results. Risk of bias, heterogeneity, and inconsistency was examined. Twenty studies met the inclusion criteria. A total of 95 ESs were calculated, representing 949 participants. During physical practice, performance increases from pretest to acquisition when receiving AF (ES = 0.87; 95%CI = 0.65, 1.10; n = 47; I 2 . = 74.41; Q= 183,6; p < 0.01); while performance significantly decrease between the acquisition and retention phase after AF was removed (ES = -0.74; 95%CI = -1.04, -0.44; n = 45; I 2 . = 88.34; Q = 377.45; p < 0.01). Age and skill level ability of the participants, type of task, and practice characteristics, and type of feedback were analyzed as potentially moderator variables. Results suggest that AF increases performance in motor skills during physical practice, but performance decreases after removing AF in retention; all due, AF enhances learning of motor skills.

Considering the increasing number of low cost vegetable oil product adulterations, it is necessary to assess the authenticity of the lipid sources used in the dog food manufacture, consequently different brands and classifications of feed were analyzed to verify the product authenticity by gas chromatography (GC) with flame ionization detector (FID) and by electrospray ionization mass spectrometry (ESI-MS). Fatty acid (FA) composition analysis was performed to compare the FAs amount in samples with the respective guarantee levels stated by the manufacturers on its product label. Gas chromatography with flame ionization detector (GC-FID) results for omega-3 and 6 percentages are within the limits presented by each manufacturer, while the timnodonic + cervonic acids amount information presented on feed sample labels is not in accordance with GC-FID results. Consequently, the samples were analyzed by ESI-MS, the results exposed the chicken oil presence in the feed and eicosapentaenoic (EPA) + docosahexaenoic (DHA) acids absence, since no lipid profiles similar to fish oils or triacylglycerols (TAGs) containing these two FAs were found. Thus, the information presented on labels are in disagreement with the results obtained both by GC-FID FA composition analysis and by ESI-MS lipid profile analysis. Principal component analysis (PCA) confirmed that the main contribution was from FAs found by GC-FID.

ABSTRACT This investigation was carried out to determine the effect of Essential Fatty Acids proportion (EFAs [n-6, n-3]) in feed through the mixture of soy, olive, canola or chia oil on EFA profile in eggs as well as productive and reproductive performance of Japanese quail. We used 120 quail from 7 to 22 weeks of age, in 15 cages in groups of 6 females and 2 males assigned according to the completely randomized design to 3 treatments with 5 replicates. The treatments were n-6:n-3 proportions 10:1 (control), 4:1 and 1:1. FA profile in yolk, feed intake, laying rate, egg weight, fertility, hatchability, and embryonic mortality were measured. In the egg yolk, n-6 content was similar in the proportions (p>0.05), while n-3 content increased (p<0.01) as n-6:n-3 ratio decreased in the feed. Feed consumption per quail was similar between treatments (p>0.05). In 4:1 and 1:1 proportion laying percentage was greater, but egg weight was lower (p<0.01). Fertility and hatchability were similar between proportions n-6, n-3 (p>0.68). Early and total embryonic mortality was lower in 10:1 and 4:1 proportion (p<0.01); while intermediate and late mortality was similar (p>0.30). The results of the experiment indicate that the mixture of soy, olive, canola or chia oil, to obtain n-6:n-3 proportion of 1:1, 4:1 and 10:1 does not modify feed consumption, laying rate, egg weight, fertility, and hatchability; but, 4:1 and 10:1 proportions favor a lower embryonic mortality.

Resumo Introdução Para melhorar a compreensão da interface entre dependência de smartphone (DS) e a dependência de Facebook (DF), avaliamos a hipótese de que a ocorrência simultânea de ambas as dependências corelaciona-se com o número de consequências negativas por elas produzidas. Além disso, avaliamos se a DS está associada a níveis mais baixos de satisfação com o suporte social. Método Recrutamos uma amostra de conveniência de estudantes de graduação da Universidade Federal de Minas Gerais, na faixa de 18 e 35 anos. Todos os sujeitos preencheram o questionário avaliando dados sociodemográficos e contendo a versão brasileira do Smartphone Addiction Inventory, a Escala de Bergen para DF, a Escala de Impulsividade de Barrat 11 (BIS-11), a Escala de Satisfação com o Suporte Social (SSSS) e a Escala Breve de Busca de Sensações (BSSS-8). Após o preenchimento do questionário, os entrevistadores realizaram a Mini-International Neuropsychiatric Interview. Resultados Na análise univariada, a DS associou-se ao sexo feminino, pessoas na faixa de idade entre 18 e 25 anos, rastreio para DF, transtornos por uso de substâncias, transtorno depressivo maior, transtornos de ansiedade, baixos escores na SSSS, altos escores na BSSS-8 e altos escores na BIS. O grupo rastreado positivamente para DS e DF apresentou maior prevalência de transtornos por uso de substâncias, depressão e transtornos de ansiedade quando comparado ao grupo rastreado apenas para DS. Conclusão Na amostra avaliada, a comorbidade de DS e DF se correlacionou a níveis mais altos de consequências negativas e níveis mais baixos de satisfação com o suporte social. Esses resultados sugerem que DS e DF compartilham fatores de vulnerabilidade. Estudos adicionais são necessários para esclarecer a direção dessas associações.

Abstract Introduction To improve the comprehension of the interface between smartphone addiction (SA) and Facebook addiction (FA), we hypothesize that the occurrence of both technological addictions correlate, with higher levels of negative consequences. Moreover, we hypothesize that SA is associated with lower levels of social support satisfaction. Methods We recruited a convenience sample of undergraduate students from Universidade Federal de Minas Gerais, with age ranging between 18 and 35 years. All subjects completed a self-fulfilled questionnaire comprising sociodemographic data, the Brazilian Smartphone Addiction Inventory (SPAI-BR), the Bergen Scale for Facebook Addiction, the Barrat Impulsivity Scale 11 (BIS-11), the Social Support Satisfaction Scale (SSSS), and the Brief Sensation Seeking Scale (BSSS-8). After completing the questionnaire, the interviewer conducted a Mini-International Neuropsychiatric Interview (MINI). Results In the univariate analysis, SA associated with female gender, with ages 18 to 25 years, FA, substance abuse disorders, major depressive disorder, anxiety disorders, low scores in SSSS, high scores in BSSS-8, and high scores in BIS. The group with SA and FA presented a higher prevalence of substance abuse disorders, depression, and anxiety disorders when compared to the group with SA only. Conclusion In our sample, co-occurrence of SA and FA correlated with higher levels of negative consequences and lower levels of social support satisfaction. These results strongly suggest that SA and FA share some elements of vulnerability. Further studies are warranted to clarify the directions of these associations.

Abstracts: Classic renin-angiotensis pathway (RAP) is activated in patients with pulmonary artery hypertension (PAH). We have previously shown that in patients with post myocardial infarction systolic dysfunction the activation of RAP mediated by angiotensin converting enzyme (ACE) and angiotensin II (Ang II) is inversely correlated with the parallel RAP axis mediated by homologous ACE (ACE2) and by the vasoactive and cardioprotective peptide Ang-(1-9). Pre clinical studies show that administration of Ang-(1-9) leads to a favorable ventricular remodelling. At present there is no information regarding levels of Ang-(1-9) in PAH patients compared to healthy subjects. Methods: 16 PAH patients (WHO group 1), with mean PA pressure > 25mmHg being treated with furosemide (40%), Bosentan/Ambrisentan (27%), Sildenafil (80%), iloprost (7%) were compared with healthy subjects (n=14). mPAP, pro BNP, pulmonary vascular resistance (Wu), pulmonary capillary pressure (PCP mmHg), cardiac output (L/min), functional capacity (6 min walking test) (6mWT), and changes in right ventricular fractional area (RV FA), were measured in all subjects. Results: In HAP subjects, the eiotology of PAH was unknown in 87%, or HIV (13%). Functional class was I (6.2 %), II (68.3%) or III (25%). Mean PAP was 51.3±1.9. Compared to healthy subjects, PAH patients had significantly lower RV FA, ACE2 and Ang-(19) levels. Also they had greater ACE plasma activity and AngII circulating levels. Significant correlations were found between Ang-(1-9) and mPAP (-0.701, p < 0,001) and between Ang-(1-9) and RV FA (r = 0.549, p < 0,01). Conclusion: group I PAH subjects, circulating levels of Ang-(1-9) are significantly lower than in healthy subjects and are inversely related to PAP, severity of ventricular remodeling and right ventricular dysfunction. The use of Ang-(1-9) as a vasodilator and cardioprotector agent could be clinically useful in PAH subjects.

Resumen: Introducción: La vía clásica del sistema renina-angiotensina (SRA) está activado en pacientes con hipertensión arterial pulmonar (HAP). Previamente, hemos encontrado que en la disfunción ventricular post infarto al miocardio experimental la activación del eje clásico del SRA, dado por la enzima convertidora de angiotensina I (ECA) y angiotensina (Ang ) II se correlaciona negativamente con el eje paralelo del SRA dado por la ECA homóloga (ECA2) y el péptido vasoactivo y cardioprotector Ang-(1-9). Resultados preclínicos muestran la eficacia de la administración de Ang-(1-9) en el tratamiento del remodelamiento cardiovascular patológico. Hasta la fecha no existen antecedentes de los niveles circulantes de Ang-(1-9) en pacientes con hipertensión arterial pulmonar comparados con sujetos sanos. Objetivo: Determinar los niveles circulantes del péptido vasoactivo y cardiprotector Ang-(1-9) en pacientes con HAP y compararlos con sujetos sanos pareados por edad y sexo. Métodos: Estudio comparativo transversal en pacientes con HAP (grupo I, OMS) con presión de arteria pulmonar media (mPAP) ≥25 mmHg bajo tratamiento con furosemida (40%), espironolactona (53%), Acenocumarol/Warfarina (47%), Bosentan/Ambrisentan (27%), Sildenafil (80%), iloprost (7%) y digoxina (13%). Los sujetos controles correspondieron a sujetos asintomáticos sanos sin enfermedad cardiovascular, cardiopatía estructural ni pulmonar (n=14). En todos los pacientes se determinó mPAP, proBNP, resistencia vascular pulmonar (RVP, WU), presión capilar pulmonar (PCP, mmHg), gasto cardíaco (L/min), capacidad funcional por test de caminata 6 minutos (TC6M), cambio del área fraccional del ventrículo derecho VD (FAC, %). Se utilizó prueba t de Student y programa estadístico SPSS10.0. Un valor de p < 0,05 fue considerado como estadísticamente significativo. Resultados: Los pacientes ingresados al estudio mostraron: etiología de la HAP, idiopática (86,7%), VIH (13,3%), capacidad funcional I (6,2%), II (68,3) y III (25%) y promedio mPAP 51,3±1,9. Pacientes con HAP (grupo I, OMS) versus sujetos sanos mostraron disminución significativa de FAC, actividad plasmática de la ECA2 y niveles circulantes de Ang-(1-9). En la vía clásica del RAAS pacientes con HAP mostraron mayor actividad plasmática de ECA y niveles circulantes e Ag II. Correlaciones significativas se encontraron entre niveles de Ang-(1-9) y mPAP (r = -0.701, p < 0,001) y Ang-(1-9) vs FAC (r = 0.549, p < 0,01). Conclusiones: En pacientes con HAP (grupo I, OMS), los niveles circulantes de Ang-(1-9) están significativamente disminuidos y se asocian inversamente con la PAP, severidad del remodelamiento y disfunción del ventrículo derecho. El uso terapéutico de Ang-(1-9) como agente vasodilatador y cardioprotector podría ser relevante y potencialmente útil, desde una perspectiva clínica, en la HAP. Ang-(1-9) podría reducir la PAP y mejorar el remodelamiento vascular y del ventrículo derecho en la HAP. Por lo tanto, este péptido podría ser útil como blanco terapéutico en la HAP.