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1.
Fenofibrate attenuates renal lipotoxicity in uninephrectomized mice with high-fat diet-induced obesity highfat high fat dietinduced diet induced
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Castro, Barbara Bruna Abreu
; Reno, Petrus Ferreira
; Pereira, Bianca Fatima
; Arriel, Kaique
; Bonato, Fabiana Bastos
; Colugnati, Fernando Antonio Basile
; Cenedeze, Marcos Antonio
; Saraiva-Camara, Niels Olsen
; Sanders-Pinheiro, Helady
.
Resumo Introdução: O objetivo deste estudo foi investigar o papel do fenofibrato, um agonista do receptor ativado por proliferadores de peroxissoma-α, na lesão renal induzida por obesidade (lipotoxicidade) em camundongos submetidos à uninefrectomia. Métodos: Camundongos C57BL/6 foram submetidos a uninefrectomia e cirurgias simuladas (sham) e alimentados com dietas normocalóricas ou rica em gordura. Após 10 semanas, os camundongos obesos receberam fenofibrato a 0,02% por 10 semanas. Avaliamos função e morfologia renal, bem como níveis de mediadores inflamatórios e fibróticos e marcadores do metabolismo lipídico. Resultados: Camundongos alimentados com dieta rica em gordura desenvolveram obesidade e hiperlipidemia características, com subsequente acúmulo de lipídios e danos renais, incluindo expansão mesangial, fibrose intersticial, inflamação e proteinúria. Essas alterações foram maiores em camundongos obesos uninefrectomizados do que em camundongos obesos sham. O tratamento com fenofibrato preveniu hiperlipidemia e lesões glomerulares, reduziu o acúmulo de lipídios, melhorou a disfunção renal e atenuou a inflamação e fibrose renal. Além disso, o tratamento com fenofibrato reduziu a expressão no tecido renal do inibidor do ativador do plasminogênio-1, da proteína quimiotática de monócitos-1 e a expressão local do fator de crescimento de fibroblastos-21. Conclusão: A ativação do receptor ativado por proliferadores de peroxissoma-α pelo fenofibrato, com subsequente lipólise, atenuou lesões glomerulares e tubulointersticiais induzidas por lipotoxicidade renal, protegendo, assim, os rins de camundongos uninefrectomizados contra lesões induzidas por obesidade. Os achados do estudo sugerem uma via na ação farmacológica do fenofibrato, fornecendo insights sobre os mecanismos envolvidos no dano renal causado pela obesidade em doadores renais. Introdução peroxissomaα, peroxissomaα peroxissoma α, α (lipotoxicidade Métodos C57BL6 CBL C57BL 6 C BL C57BL/ sham (sham 1 semanas 002 0 02 0,02 lipídico Resultados características renais mesangial intersticial proteinúria disso plasminogênio1, plasminogênio1 plasminogênio 1, plasminogênio-1 monócitos1 monócitos monócitos- fibroblastos21. fibroblastos21 fibroblastos 21. 21 fibroblastos-21 Conclusão lipólise protegendo assim 00 0,0 plasminogênio- fibroblastos2 2 fibroblastos-2 0, fibroblastos-
Abstract Introduction: The objective of this study was to investigate the role of fenofibrate, a peroxisome proliferator-activated receptor-α agonist, in obesity-induced kidney damage (lipotoxicity) in mice with uninephrectomy. Methods: C57BL/6 mice underwent uninephrectomy and sham surgeries and were fed normocaloric or high-fat diets. After 10 weeks, obese mice were administered 0.02% fenofibrate for 10 weeks. Kidney function and morphology were evaluated, as well as levels of inflammatory and fibrotic mediators and lipid metabolism markers. Results: High-fat diet-fed mice developed characteristic obesity and hyperlipidemia, with subsequent renal lipid accumulation and damage, including mesangial expansion, interstitial fibrosis, inflammation, and proteinuria. These changes were greater in obese uninephrectomy mice than in obese sham mice. Fenofibrate treatment prevented hyperlipidemia and glomerular lesions, lowered lipid accumulation, ameliorated renal dysfunction, and attenuated inflammation and renal fibrosis. Furthermore, fenofibrate treatment downregulated renal tissue expression of plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, and local expression of fibroblast growth factor-21. Conclusion: Peroxisome proliferator-activated receptor-α activation by fenofibrate, with subsequent lipolysis, attenuated glomerular and tubulointerstitial lesions induced by renal lipotoxicity, thus protecting the kidneys of uninephrectomy mice from obesity-induced lesions. The study findings suggest a pathway in the pharmacological action of fenofibrate, providing insight into the mechanisms involved in kidney damage caused by obesity in kidney donors. Introduction proliferatoractivated proliferator activated receptorα receptor α agonist obesityinduced lipotoxicity (lipotoxicity Methods C57BL6 CBL C57BL 6 C BL C57BL/ highfat high fat diets 1 weeks 002 0 02 0.02 evaluated markers Results Highfat High dietfed diet expansion fibrosis proteinuria dysfunction Furthermore inhibitor1, inhibitor1 inhibitor 1, inhibitor-1 protein1, protein1 protein protein-1 factor21. factor21 factor 21. 21 factor-21 Conclusion lipolysis donors 00 0.0 inhibitor- protein- factor2 2 factor-2 0. factor-
2.
O trabalho em domicílio no Brasil pré-pandemia: mudanças no setor de atividade e no perfil das/os trabalhadoras/es prépandemia pré pandemia pré-pandemia dasos das os trabalhadorases trabalhadoras es
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Resumo O trabalho remoto atingiu 11% da população ocupada do Brasil no contexto da pandemia da COVID-19: uma maioria de mulheres, pessoas brancas, com nível superior de escolaridade, e atuantes no setor de educação e serviços. Esse perfil é distinto do padrão predominante de trabalhadores em domicílio: mulheres negras com baixo nível de escolaridade e atuantes na indústria de transformação. Mas, ao revisar os dados da PNAD entre 1992 e 2019, encontramos algumas transformações nos setores da economia e atividades ocupacionais realizados em domicílio, bem como uma mudança no perfil do trabalhador em domicílio: crescimento na participação de homens com maior nível de escolaridade e remuneração e atuantes no setor de serviços e de comunicação. Defendemos, neste artigo, que essas mudanças no trabalho em domicílio observadas na pré-pandemia contribuem para compreender o espaço que o trabalho remoto ganhou durante e após a pandemia para se fortalecer enquanto modalidade de trabalho e se justificar enquanto alternativa de organização de espaço de trabalho. 11 COVID19 COVID 19 COVID-19 brancas transformação Mas 199 2019 comunicação Defendemos artigo prépandemia pré 1 COVID1 COVID-1 201 COVID- 20 2
Resumé Le télétravail à domicile a atteint 11% de la population occupée du pays dans le contexte de la pandémie de COVID-19. Il s'agissait en majorité de femmes, de personnes blanches, diplômées de l'enseignement supérieur, et travaillant dans les secteurs des services et de la communication. La réalité des télétravailleurs à domicile est différente de celle de la plupart des travailleurs à domicile d'avant la pandémie: femmes noires, peu scolarisées et travaillant dans l'industrie manufacturière. Cependant, en examinant les données du PNAD entre 1992 et 2019, on peut observer la croissance, dans ce type de travail, de la participation des hommes ayant une formation et une rémunération supérieures et travaillant dans les secteurs des services et de la communication. En ce sens, bien que le travail à domicile ait peu varié dans le période, certaines tendances d'évolution de ce type de travail se dégagent des données, réalisées à domicile et sur le profil du travailleur à domicile. Nous comprenons que ces changements observés dans la pré pandémie contribuent à comprendre l'espace que le télétravail à domicile a gagné dans la pandémie, à se renforcer comme modalité de travail et à se justifier comme alternative pour organiser l'espace de travail. 11 COVID19. COVID19 COVID 19. 19 COVID-19 sagissait s agissait blanches lenseignement l enseignement supérieur communication davant d avant noires lindustrie industrie manufacturière Cependant 199 2019 croissance sens période dévolution évolution lespace espace 1 COVID1 COVID-1 201 COVID- 20 2
Abstract Remote work reached 11% of Brazil's employed population in the context of the COVID-19 pandemic: the majority being women, white individuals with higher education levels, and working in the education and services sectors. This profile is distinct from the predominant pattern of home-based workers: black women with lower education levels and working in the manufacturing industry. However, upon reviewing PNAD data from 1992 to 2019, we found some transformations in home-based economic sectors and occupational activities. Additionally, there has been a shift in the profile of home-based workers: an increase in the participation of men with higher education and income levels, working in the services and communication sectors. In this article, we argue that these pre-pandemic changes in home-based work contribute to understanding the space that remote work has gained during and after the pandemic to strengthen itself as a work modality and justify itself as an alternative for organizing workspaces. 11 Brazils Brazil s COVID19 COVID 19 COVID-1 homebased home based workers industry However 199 2019 activities Additionally article prepandemic pre workspaces 1 COVID1 COVID- 201 20 2
3.
Parturientes adolescentes em Cruzeiro do Sul, Acre, Brasil: características socioeconômicas e obstétricas
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Damasceno, Ana Alice de Araújo
; Cardoso, Marly Augusto
; Cardoso, Marly Augusto
; Matijasevich, Alicia
; Lourenço, Bárbara Hatzlhoffer
; Abanto, Jenny
; Malta, Maíra Barreto
; Ferreira, Marcelo Urbano
; Neves, Paulo Augusto Ribeiro
; Damasceno, Ana Alice
; Silva, Bruno Pereira da
; Souza, Rodrigo Medeiros de
; Ladeia-Andrade, Simone
; Castro, Márcia Caldas de
.
Abstract The present study aimed to investigate the socioeconomic and obstetric characteristics of adolescent mothers and the complications they cause to maternal and neonatal health. This baseline data analysis of the MINA-Brazil birth cohort was conducted in the municipality of Cruzeiro do Sul, state of Acre, Brazil. The chi-square test was used to compare characteristics of adolescent and adult postpartum women, and multiple Poisson regression models with robust variance were used to assess associated factors. Among the postpartum women, 26.2% (95%CI: 24.0-28.4) were adolescents. Factors associated with childbirth in adolescence included: nine years or less of schooling (adjPR:1.36; 95%CI: 1.14-1.61), belongs to the lowest quartiles of the wealth index (1st quartile: adjPR:1.40; 95%CI: 1.08-1.80) (2nd quartile: adjPR:1.37; 95%CI: 1.08-1.74), primigravidae (adjPR:3.69; 95%CI: 2.98-4.57), low pre-pregnancy BMI (adjPR:1.28; CI95%: 1.04-1.57), urinary tract infection during pregnancy (adjPR:1.25; CI95%: 1.07-1.46) and less than six prenatal consultations (adjPR:1.42; 95%CI: 1.21-1.66). Poverty, little schooling, primigravidae, low pre-pregnancy BMI, urinary tract infection during pregnancy and few prenatal consultations were associated with childbirth during adolescence in a municipality in the Northern region of Brazil.
Resumo O objetivo do estudo foi investigar as características socioeconômicas e obstétricas de parturientes adolescentes e suas complicações sobre a saúde materna e neonatal. Trata-se de uma análise de dados da linha de base da coorte de nascimentos MINA-Brasil conduzida no município de Cruzeiro do Sul, estado do Acre. Utilizou-se teste qui-quadrado para comparar características das puérperas adolescentes com as adultas e modelos múltiplos de regressão de Poisson com variância robusta para avaliar fatores associados. Entre as puérperas estudadas, 26,2% (IC95%: 24,0-28,4) eram adolescentes. Os fatores associados ao parto na adolescência foram ter nove anos ou menos de estudo (RPaj:1,36; IC95%: 1,14-1,61), pertencer aos menores quartis do índice de riqueza (1° quartil: RPaj:1,40; IC95%: 1,08-1,80) (2° quartil: RPaj:1,37; IC95%: 1,08-1,74), ser primigesta (RPaj:3,69; IC95%: 2,98-4,57), baixo IMC pré-gestacional (RPaj:1,28; IC95%: 1,04-1,57), infecção urinária na gravidez (RPaj:1,25; IC95%: 1,07-1,46) e menos de seis consultas de pré-natal (RPaj:1,42; IC95%: 1,21-1,66). Pobreza, baixa escolaridade, primigestação, baixo IMC pré-gestacional, infecção urinária na gestação e menor número de consultas de pré-natal foram associados ao parto na adolescência em município da região Norte do Brasil.
4.
Vaccine coverage by social strata in state capitals in the Brazilian Midwest region: a household survey of children born in 2017 and 2018
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Lima, Jaqueline Costa
; Garcia, Érica Marvila
; Oliveira, Sandra Maria do Valle Leone de
; Araújo, Wildo Navegantes de
; Lopes, Emmanuela Maria de Freitas
; Teles, Sheila Araújo
; Caetano, Karlla Antonieta Amorim
; Teixeira, Ana Izabel Passarela
; Alves, Bárbara Manuella Cardoso Sodré
; França, Ana Paula
; Moraes, José Cássio de
; Domingues, Carla Magda Allan Santos
; Silva, Adriana Ilha da
; Ramos Jr., Alberto Novaes
; França, Ana Paula
; Oliveira, Andrea de Nazaré Marvão
; Boing, Antonio Fernando
; Domingues, Carla Magda Allan Santos
; Oliveira, Consuelo Silva de
; Maciel, Ethel Leonor Noia
; Guibu, Ione Aquemi
; Mirabal, Isabelle Ribeiro Barbosa
; Barbosa, Jaqueline Caracas
; Lima, Jaqueline Costa
; Moraes, José Cássio de
; Luhm, Karin Regina
; Caetano, Karlla Antonieta Amorim
; Lima, Luisa Helena de Oliveira
; Antunes, Maria Bernadete de Cerqueira
; Teixeira, Maria da Gloria
; Teixeira, Maria Denise de Castro
; Borges, Maria Fernanda de Sousa Oliveira
; Queiroz, Rejane Christine de Sousa
; Gurgel, Ricardo Queiroz
; Barata, Rita Barradas
; Azevedo, Roberta Nogueira Calandrini de
; Oliveira, Sandra Maria do Valle Leone de
; Teles, Sheila Araújo
; Gama, Silvana Granado Nogueira da
; Mengue, Sotero Serrate
; Simões, Taynãna César
; Nascimento, Valdir
; Araújo, Wildo Navegantes de
.
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ABSTRACT Objective To analyze full vaccination coverage in live births in 2017 and 2018 in the capitals of the Midwest region of Brazil, according to social strata. Methods Population-based household survey with cluster sampling. Full coverage in children at 12 and 24 months of age and sociodemographic factors were analyzed. Results 5,715 children were analyzed. Full coverage at 12 months of age was 67.9% (95%CI 65.4;70.4), while at 24 months it was 48.2% (95%CI 45.3;51.1). Pneumococcal vaccine had the highest vaccination coverage (91.3%), while the second dose of rotavirus vaccine had the lowest (74.2%). In Campo Grande, no vaccine reached coverage above 90%, with BCG (82.9%) and hepatitis B (82.1%) standing out. Campo Grande and Brasília had the worst vaccination coverage in the high social stratum (24 months of age). Conclusion Vaccination coverage in the Midwest was below 80%, falling short of the recommended target and associated with socioeconomic factors.
RESUMO Objetivo Analisar a cobertura vacinal completa em nascidos vivos em 2017 e 2018, nas capitais da região Centro-Oeste do Brasil, segundo estratos sociais. Métodos Inquérito domiciliar de base populacional com amostragem por conglomerados. Analisou-se a cobertura vacinal completa em crianças aos 12 e 24 meses de idade e os fatores sociodemográficos. Resultados Foram analisadas 5.715 crianças. A cobertura completa aos 12 meses de idade foi 67,9% (IC95% 65,4;70,4) e aos 24 meses de idade foi 48,2% (IC95% 45,3;51,1). A maior cobertura foi da vacina pneumococo (91,3%) e a pior da segunda dose da vacina rotavírus (74,2%). Em Campo Grande, nenhuma vacina alcançou cobertura acima de 90%, destacando-se as vacinas BCG (82,9%) e hepatite B (82,1%). Campo Grande e Brasília tiveram piores coberturas vacinais no estrato social alto (24 meses de idade). Conclusão A cobertura vacinal na região Centro-Oeste foi inferior a 80%, abaixo da meta preconizada e associada com fatores socioeconômicos.
5.
PERFIL VOLÁTIL DO Coffea arabica E Coffea canephora var. conilon POR SHS-GC-MS E QUIMIOMETRIA var SHSGCMS SHS GC MS
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Lyrio, Marcos Valério Vieira
; Cunha, Pedro Henrique Pereira da
; Debona, Danieli Grancieri
; Agnoletti, Bárbara Zani
; Frinhani, Roberta Quintino
; Oliveira, Emanuele Catarina da Silva
; Filgueiras, Paulo Roberto
; Pereira, Lucas Louzada
; Castro, Eustáquio Vinicius Ribeiro de
.
The volatile composition of coffee exerts a substantial influence on its quality, as it defines the characteristics of the beverage. However, these compounds are influenced by factors within the coffee production chain, such as botanical origin, geography, processing methods, and roasting. Consequently, the identification of such compounds becomes a vital tool for characterizing coffees to these factors. In this context, gas chromatography with headspace extraction is widely used for aroma analysis, providing a composition closer to consumer perception. Headspace extraction offers speed, simplicity, minimal sample preparation, and no need for solvents. In this study, static headspace extraction (SHS) coupled with gas chromatography-mass spectrometry (SHS-GC-MS) was employed to establish the chemical profile of volatile compounds in Coffea arabica and Coffea canephora var. conilon and determine discriminants between the species. A total of 97 compounds, belonging to 17 chemical classes, were identified. The chemometric analysis highlighted furans, phenols, and carboxylic acids as key differentiating classes. Notably, furfuryl alcohol, acetic acid, 4-vinylguaiacol, N-acetyl-4(H)-pyridine, and N-furfurylpyrrole emerged as crucial volatile compounds. The variable selection using Fisher weight applied directly in the chromatograms, produced models consistent with relative area data, with furfuryl alcohol and 4-vinylguaiacol regions being particularly influential in differentiation. quality beverage However chain origin geography methods roasting Consequently context perception speed simplicity preparation solvents study SHS (SHS chromatographymass mass SHSGCMS GC MS (SHS-GC-MS var species 9 1 classes identified furans phenols Notably acid 4vinylguaiacol, 4vinylguaiacol vinylguaiacol 4 vinylguaiacol, Nacetyl4Hpyridine, Nacetyl4Hpyridine NacetylHpyridine N acetyl H pyridine, pyridine N-acetyl-4(H)-pyridine Nfurfurylpyrrole furfurylpyrrole chromatograms data differentiation Nacetyl Hpyridine
6.
Parturientes adolescentes em Cruzeiro do Sul, Acre, Brasil: características socioeconômicas e obstétricas Sul Acre Brasil
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Damasceno, Ana Alice de Araújo
; Cardoso, Marly Augusto
; Cardoso, Marly Augusto
; Matijasevich, Alicia
; Lourenço, Bárbara Hatzlhoffer
; Abanto, Jenny
; Malta, Maíra Barreto
; Ferreira, Marcelo Urbano
; Neves, Paulo Augusto Ribeiro
; Damasceno, Ana Alice
; Silva, Bruno Pereira da
; Souza, Rodrigo Medeiros de
; Ladeia-Andrade, Simone
; Castro, Márcia Caldas de
.
Resumo O objetivo do estudo foi investigar as características socioeconômicas e obstétricas de parturientes adolescentes e suas complicações sobre a saúde materna e neonatal. Trata-se de uma análise de dados da linha de base da coorte de nascimentos MINA-Brasil conduzida no município de Cruzeiro do Sul, estado do Acre. Utilizou-se teste qui-quadrado para comparar características das puérperas adolescentes com as adultas e modelos múltiplos de regressão de Poisson com variância robusta para avaliar fatores associados. Entre as puérperas estudadas, 26,2% (IC95%: 24,0-28,4) eram adolescentes. Os fatores associados ao parto na adolescência foram ter nove anos ou menos de estudo (RPaj:1,36; IC95%: 1,14-1,61), pertencer aos menores quartis do índice de riqueza (1° quartil: RPaj:1,40; IC95%: 1,08-1,80) (2° quartil: RPaj:1,37; IC95%: 1,08-1,74), ser primigesta (RPaj:3,69; IC95%: 2,98-4,57), baixo IMC pré-gestacional (RPaj:1,28; IC95%: 1,04-1,57), infecção urinária na gravidez (RPaj:1,25; IC95%: 1,07-1,46) e menos de seis consultas de pré-natal (RPaj:1,42; IC95%: 1,21-1,66). Pobreza, baixa escolaridade, primigestação, baixo IMC pré-gestacional, infecção urinária na gestação e menor número de consultas de pré-natal foram associados ao parto na adolescência em município da região Norte do Brasil. neonatal Tratase Trata se MINABrasil MINA Brasil Sul Acre Utilizouse Utilizou quiquadrado qui quadrado estudadas 262 26 2 26,2 IC95% IC95 IC (IC95% 24,028,4 240284 24,0 28,4 24 0 28 4 24,0-28,4 RPaj1,36 RPaj136 RPaj 1,36 1 36 (RPaj:1,36 1,141,61, 114161 1,14 1,61 , 14 61 1,14-1,61) 1° (1 quartil RPaj1,40 RPaj140 1,40 40 RPaj:1,40 1,081,80 108180 1,08 1,80 08 80 1,08-1,80 2° (2 RPaj1,37 RPaj137 1,37 37 RPaj:1,37 1,081,74, 108174 1,74 74 1,08-1,74) RPaj3,69 RPaj369 3,69 3 69 (RPaj:3,69 2,984,57, 298457 2,98 4,57 98 57 2,98-4,57) prégestacional pré gestacional RPaj1,28 RPaj128 1,28 (RPaj:1,28 1,041,57, 104157 1,04 1,57 04 1,04-1,57) RPaj1,25 RPaj125 1,25 25 (RPaj:1,25 1,071,46 107146 1,07 1,46 07 46 1,07-1,46 prénatal natal RPaj1,42 RPaj142 1,42 42 (RPaj:1,42 1,211,66. 121166 1,21 1,66 . 21 66 1,21-1,66) Pobreza escolaridade primigestação prégestacional, gestacional, 26, IC9 (IC95 028 24,028, 24028 240 24, 284 28, 24,0-28, RPaj1 RPaj1,3 RPaj13 136 1,3 (RPaj:1,3 141 1,141,61 11416 114 1,1 161 1,6 6 1,14-1,61 ( RPaj1,4 RPaj14 140 1,4 RPaj:1,4 081 1,081,8 10818 108 1,0 180 1,8 8 1,08-1,8 137 RPaj:1,3 1,081,74 10817 174 1,7 7 1,08-1,74 RPaj3 RPaj3,6 RPaj36 369 3,6 (RPaj:3,6 984 2,984,57 29845 298 2,9 457 4,5 9 5 2,98-4,57 RPaj1,2 RPaj12 128 1,2 (RPaj:1,2 041 1,041,57 10415 104 157 1,5 1,04-1,57 125 071 1,071,4 10714 107 146 1,07-1,4 142 (RPaj:1,4 211 1,211,66 12116 121 166 1,21-1,66 (IC9 02 24,028 2402 24,0-28 RPaj1, 13 1, (RPaj:1, 1,141,6 1141 11 16 1,14-1,6 RPaj:1, 1,081, 1081 10 18 1,08-1, 1,081,7 17 1,08-1,7 RPaj3, 3, (RPaj:3, 2,984,5 2984 29 2, 45 4, 2,98-4,5 12 1,041,5 1041 15 1,04-1,5 1,071, 1071 1,07-1, 1,211,6 1211 1,21-1,6 (IC 24,02 24,0-2 (RPaj:1 1,141, 1,14-1, RPaj:1 1,081 1,08-1 (RPaj:3 2,984, 2,98-4, 1,041, 1,04-1, 1,071 1,07-1 1,211, 1,21-1, 24,0- (RPaj: 1,141 1,14-1 RPaj: 1,08- 2,984 2,98-4 1,041 1,04-1 1,07- 1,211 1,21-1 (RPaj 1,14- 2,98- 1,04- 1,21-
Abstract The present study aimed to investigate the socioeconomic and obstetric characteristics of adolescent mothers and the complications they cause to maternal and neonatal health. This baseline data analysis of the MINA-Brazil birth cohort was conducted in the municipality of Cruzeiro do Sul, state of Acre, Brazil. The chi-square test was used to compare characteristics of adolescent and adult postpartum women, and multiple Poisson regression models with robust variance were used to assess associated factors. Among the postpartum women, 26.2% (95%CI: 24.0-28.4) were adolescents. Factors associated with childbirth in adolescence included: nine years or less of schooling (adjPR:1.36; 95%CI: 1.14-1.61), belongs to the lowest quartiles of the wealth index (1st quartile: adjPR:1.40; 95%CI: 1.08-1.80) (2nd quartile: adjPR:1.37; 95%CI: 1.08-1.74), primigravidae (adjPR:3.69; 95%CI: 2.98-4.57), low pre-pregnancy BMI (adjPR:1.28; CI95%: 1.04-1.57), urinary tract infection during pregnancy (adjPR:1.25; CI95%: 1.07-1.46) and less than six prenatal consultations (adjPR:1.42; 95%CI: 1.21-1.66). Poverty, little schooling, primigravidae, low pre-pregnancy BMI, urinary tract infection during pregnancy and few prenatal consultations were associated with childbirth during adolescence in a municipality in the Northern region of Brazil. health MINABrazil MINA Brazil Sul Acre chisquare chi square women factors 262 26 2 26.2 95%CI 95CI CI 95 (95%CI 24.028.4 240284 24.0 28.4 24 0 28 4 24.0-28.4 adolescents included adjPR1.36 adjPR136 adjPR 1.36 1 36 (adjPR:1.36 1.141.61, 114161 1.14 1.61 , 14 61 1.14-1.61) 1st st quartile adjPR1.40 adjPR140 1.40 40 adjPR:1.40 1.081.80 108180 1.08 1.80 08 80 1.08-1.80 2nd nd adjPR1.37 adjPR137 1.37 37 adjPR:1.37 1.081.74, 108174 1.74 74 1.08-1.74) adjPR3.69 adjPR369 3.69 3 69 (adjPR:3.69 2.984.57, 298457 2.98 4.57 98 57 2.98-4.57) prepregnancy pre adjPR1.28 adjPR128 1.28 (adjPR:1.28 CI95% CI95 1.041.57, 104157 1.04 1.57 04 1.04-1.57) adjPR1.25 adjPR125 1.25 25 (adjPR:1.25 1.071.46 107146 1.07 1.46 07 46 1.07-1.46 adjPR1.42 adjPR142 1.42 42 (adjPR:1.42 1.211.66. 121166 1.21 1.66 . 21 66 1.21-1.66) Poverty 26. 9 028 24.028. 24028 240 24. 284 28. 24.0-28. adjPR1 adjPR1.3 adjPR13 136 1.3 (adjPR:1.3 141 1.141.61 11416 114 1.1 161 1.6 6 1.14-1.61 adjPR1.4 adjPR14 140 1.4 adjPR:1.4 081 1.081.8 10818 108 1.0 180 1.8 8 1.08-1.8 137 adjPR:1.3 1.081.74 10817 174 1.7 7 1.08-1.74 adjPR3 adjPR3.6 adjPR36 369 3.6 (adjPR:3.6 984 2.984.57 29845 298 2.9 457 4.5 5 2.98-4.57 adjPR1.2 adjPR12 128 1.2 (adjPR:1.2 CI9 041 1.041.57 10415 104 157 1.5 1.04-1.57 125 071 1.071.4 10714 107 146 1.07-1.4 142 (adjPR:1.4 211 1.211.66 12116 121 166 1.21-1.66 02 24.028 2402 24.0-28 adjPR1. 13 1. (adjPR:1. 1.141.6 1141 11 16 1.14-1.6 adjPR:1. 1.081. 1081 10 18 1.08-1. 1.081.7 17 1.08-1.7 adjPR3. 3. (adjPR:3. 2.984.5 2984 29 2. 45 4. 2.98-4.5 12 1.041.5 1041 15 1.04-1.5 1.071. 1071 1.07-1. 1.211.6 1211 1.21-1.6 24.02 24.0-2 (adjPR:1 1.141. 1.14-1. adjPR:1 1.081 1.08-1 (adjPR:3 2.984. 2.98-4. 1.041. 1.04-1. 1.071 1.07-1 1.211. 1.21-1. 24.0- (adjPR: 1.141 1.14-1 adjPR: 1.08- 2.984 2.98-4 1.041 1.04-1 1.07- 1.211 1.21-1 (adjPR 1.14- 2.98- 1.04- 1.21-
7.
Assessing proteases and enzymes of the trypanothione system in subpopulations of Leishmania (Viannia) braziliensis Thor strain during macrophage infection Viannia (Viannia
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Albuquerque-Melo, Barbara Cristina de
; Pereira, Bernardo Acácio Santini
; Ennes-Vidal, Vítor
; Gonçalves, Maria Eduarda Pinto
; Côrtes, Luzia Monteiro de Castro
; Cysne-Finkelstein, Léa
; Guedes, Herbert Leonel de Matos
; Dias-Lopes, Geovane
; Alves, Carlos Roberto
.
BACKGROUND Leishmania (Viannia) braziliensis Thor strain exhibits a heterogeneous composition comprised of subpopulations with varying levels of infectivity. Clonal subpopulations were previously obtained from the strain Thor by sorting single-parasites and proceeding cultivation. The subpopulations used in this study are named Thor03, Thor 10 and Thor22. OBJECTIVES Phenotypic characteristics of the parasite, specially focusing on virulence factors and resistance to the antimicrobial mechanisms of macrophages, were investigate in these subpopulations. METHODS Cellular and molecular biology, as well as biochemistry approaches were applied to obtain the data analysed in this study. FINDINGS Relative quantification of gene expression was measured for calpain, cysteine protease B (CPB), and subtilisin proteases but no significant differences in these genes’ expression among subpopulations was observed. However, subtilisin and CPB proteins were assessed as more abundant in Thor03 by fluorescence-labelled flow cytometry technique. Western Blotting assays, as semi-quantitative analysis in gel, showed higher concentrations of subtilisin (110 to 50 kDa) and CPB (40 to 18 kDa) in extract of intracellular amastigotes from subpopulations Thor03 and Thor10 and calpain (60 to 25 kDa) showed no significant differences among subpopulations. Complementary, higher trypanothione reductase activity was observed in Thor10 intracellular amastigotes and assays of susceptibility to hydrogen peroxide-inducing agents and nitric oxide donors conducted with promastigotes revealed greater resistance to in vitro oxidative stress induction for Thor10, followed by Thor03. MAIN CONCLUSIONS The data obtained for the virulence factors explored here suggest how multiple coexisting phenotypic-distinct subpopulations may contribute in adaptability of a single L. (V.) braziliensis strain during infection in the host cells. Viannia (Viannia infectivity singleparasites parasites cultivation 1 Thor22 parasite macrophages biology CPB, , (CPB) genes However Thor0 fluorescencelabelled fluorescence labelled technique semiquantitative semi quantitative gel 110 (11 5 kDa 40 (4 Thor1 60 (6 2 Complementary peroxideinducing peroxide inducing phenotypicdistinct phenotypic distinct L V. V (V. cells Thor2 (CPB 11 (1 4 ( 6 (V
8.
Patient Blood Management Program Implementation: Comprehensive Recommendations and Practical Strategies Implementation
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Céspedes, Isabel Cristina
; Figueiredo, Maria Stella
; Hossne Junior, Nelson Americo
; Suriano, Ítalo Capraro
; Rodrigues, Rita de Cássia
; Barros, Melca Maria Oliveira
; Paiva Neto, Manoel Antonio de
; Atallah, Fernanda Chohfi
; Benini, Bárbara Burza
; Gonzalez, Adriano Miziara
; Sparapani, Fábio Veiga de Castro
; Barros Júnior, Newton de
; Carneiro, Ieda Aparecida
; Sarto, Celina Mayumi Morita
; Motoyama, Caio Sussumu de Macedo
; Sacchi, Leonardo
; Piovezan, Victor
; Almeida, Simone Luna de
; Pereira-Rufino, Laís da Silva
; Guizilini, Solange
; Rocco, Isadora Salvador
; Mansur, Nacime Salomão
; Arakaki, Jaquelina Sonoe Ota
; Santos, Antonio Alceu dos
; Panfilio, Carlos Eduardo
.
Brazilian Journal of Cardiovascular Surgery
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ABSTRACT Introduction: Blood transfusion is one of the most common medical practices worldwide. However, current scientific literature has shown that the immunomodulatory effects of blood transfusion are associated with an increased likelihood of infection, prolonged hospitalization, and morbimortality. Also, it means high costs for healthcare systems. Methods: In this context, acknowledging that blood transfusions are essentially heterologous cell transplantations, the use of therapeutic options has gained strength and is collectively known as the patient blood management (PBM) program. PBM is an approach based on three main pillars: (1) treating anemias and coagulopathies in an optimized manner, especially in the preoperative period; (2) optimizing perioperative hemostasis and the use of blood recovery systems to avoid the loss of the patient's blood; (3) anemia tolerance, with improved oxygen delivery and reduced oxygen demand, particularly in the postoperative period. Results: Current scientific evidence supports the effectiveness of PBM by reducing the need for blood transfusions, decreasing associated complications, and promoting more efficient and safer blood management. Thus, PBM not only improves clinical outcomes for patients but also contributes to the economic sustainability of healthcare systems. Conclusion: The aim of this review was to summarize PBM strategies in a comprehensive, evidence-based approach through a systematic and structured model for PBM implementation in tertiary hospitals. The recommendations proposed herein are from researchers and experts of a high-complexity university hospital in the network of the Sistema Único de Saúde, presenting itself as a strategy that can be followed as a guideline for PBM implementation in other settings. Introduction worldwide However infection hospitalization morbimortality Also Methods context transplantations (PBM program pillars 1 (1 manner period 2 (2 s 3 (3 tolerance demand Results complications Thus Conclusion comprehensive evidencebased hospitals highcomplexity complexity Saúde settings (
9.
Social Representations Theory and the STAM: Acceptance of the Internet among Older Adults STAM
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Castro, Amanda
; Vitali, Marieli Mezari
; Bousfield, Andréa Barbará da Silva
; Camargo, Brigido Vizeu
.
Resumo A presente pesquisa teve por objetivo compreender as representações sociais e aceitação da internet pelo modelo STAM para idosos. Participaram 18 idosos divididos em 3 grupos, por nível de inclusão (baixo, médio/alto e baixo/médio). Antes e após o grupo foi aplicado um questionário de atitudes frente à internet. Os itens do questionário foram submetidos a análises descritivas e relacionais, e os dados do grupo focal à análise de conteúdo. Percebeu-se que no primeiro grupo houve a possibilidade de rejeição da tecnologia associada à perda de tempo e não percepção de utilidade. Para o segundo e terceiro grupo a internet surge como algo que aproxima a família e exige paciência, o que favorece a alta intenção de uso e experimentação. Foi possível identificar que o pensamento do idoso sobre a internet, suas atitudes e representações sociais, não apenas sobre a rede, mas também sobre envelhecimento, influenciam na intenção de uso da internet e utilidade percebida. 1 grupos baixo, baixo (baixo médioalto médio alto baixo/médio. baixomédio baixo/médio . baixo/médio) relacionais conteúdo Percebeuse Percebeu se paciência experimentação rede envelhecimento percebida
Abstract This study aimed to understand the social representations and acceptance of the Internet among older adults through the STAM. The participants consisted of 18 older adults divided into three groups based on their level of inclusion (low, medium/high, and low/medium). Before and after the group sessions, an attitude questionnaire was administered online. The questionnaire items underwent descriptive and relational analysis, while the data from the focus group were subjected to content analysis. We observed that the first group displayed a potential rejection of the technology due to concerns about time loss and a lack of perceived usefulness. In contrast, the second and third groups viewed the Internet as a tool that brings families together and requires patience, leading to a greater intention to use it and experimentation. The study identified that the older adults’ thoughts, attitudes, and social representations, not only about the Internet but also about aging, significantly influenced their intention to use the Internet and their perception of its usefulness. STAM 1 low, low (low mediumhigh medium high medium/high low/medium. lowmedium low/medium . low/medium) sessions online analysis usefulness contrast patience experimentation thoughts attitudes aging
10.
Negative affectivity in university students and its relationship with academic performance and professional outlook after COVID-19 COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Alves, Bruna de Oliveira
; Lourenço, Bárbara Guimarães
; Araújo, Bianca Bacelar Assis
; Toledo, Luana Vieira
; Chaves, Rafael Lopes
; Chaves, Érika de Cássia Lopes
; Chianca, Tânia Couto Machado
; Moura, Caroline de Castro
.
RESUMO Objetivos: avaliar a prevalência de afetividades negativas em estudantes universitários no contexto pós-pandemia da COVID-19 e sua relação com o desempenho acadêmico e a perspectiva de futuro profissional. Métodos: estudo transversal realizado com estudantes de graduação de uma universidade pública mineira entre setembro de 2022 e setembro de 2023. Os dados foram coletados a partir do questionário de caracterização sociodemográfica e psicossocial e da Depression, Anxiety and Stress Scale 21. As relações entre as afetividades negativas, o rendimento escolar e a perspectiva de futuro profissional foram verificadas por meio do teste de Kruskal-Wallis, com 5% de significância. Resultados: participaram do estudo 585 estudantes. Verificou-se alta prevalência de depressão, ansiedade e estresse entre os estudantes universitários no contexto pós-pandemia da COVID-19, com destaque para a ansiedade em nível severo. Foi detectada associação negativa entre as afetividades negativas investigadas, o desempenho acadêmico e a perspectiva de futuro profissional. Conclusões: os resultados apontam para uma vulnerabilidade emocional dos estudantes universitários, com existência de relação entre afetividades negativas e piora do desempenho acadêmico e perspectiva de futuro profissional. Objetivos póspandemia pós pandemia COVID19 COVID 19 COVID-1 Métodos 202 2023 Depression 21 KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis 5 significância Resultados 58 Verificouse Verificou se depressão COVID19, 19, severo investigadas Conclusões COVID1 1 COVID- 20 2
ABSTRACT Objectives: to evaluate the prevalence of negative affectivity in university students in the post-COVID-19 pandemic context and its relationship with academic performance and professional outlook. Methods: a cross-sectional study was conducted with undergraduate students from a public university in Minas Gerais between September 2022 and September 2023. Data were collected using a sociodemographic and psychosocial characterization questionnaire and the Depression, Anxiety, and Stress Scale 21. The relationships between negative affectivity, academic performance, and professional outlook were verified using the Kruskal-Wallis test, with a significance level of 5%. Results: a total of 585 students participated in the study. A high prevalence of depression, anxiety, and stress was found among university students in the post-COVID-19 context, with a notable severity of anxiety. A negative association was detected between the investigated negative affectivity, academic performance, and professional outlook. Conclusions: the results indicate an emotional vulnerability in university students, with a relationship between negative affectivity and a decline in academic performance and professional outlook. Objectives postCOVID19 postCOVID post COVID 19 post-COVID-1 Methods crosssectional cross sectional 202 2023 Depression Anxiety 21 KruskalWallis Kruskal Wallis test 5 5% Results 58 depression anxiety Conclusions postCOVID1 1 post-COVID- 20 2 post-COVID
RESUMEN Objetivos: evaluar la prevalencia de afectividades negativas en estudiantes universitarios en el contexto post-pandemia de COVID-19 y su relación con el rendimiento académico y la perspectiva de futuro profesional. Métodos: estudio transversal realizado con estudiantes de pregrado de una universidad pública de Minas Gerais entre septiembre de 2022 y septiembre de 2023. Los datos fueron recolectados a partir de un cuestionario de caracterización sociodemográfica y psicosocial y de la Depression, Anxiety and Stress Scale 21. Las relaciones entre las afectividades negativas, el rendimiento escolar y la perspectiva de futuro profesional fueron verificadas mediante la prueba de Kruskal-Wallis, con un nivel de significancia del 5%. Resultados: participaron en el estudio 585 estudiantes. Se verificó una alta prevalencia de depresión, ansiedad y estrés entre los estudiantes universitarios en el contexto post-pandemia de COVID-19, destacándose la ansiedad en un nivel severo. Se detectó una asociación negativa entre las afectividades negativas investigadas, el rendimiento académico y la perspectiva de futuro profesional. Conclusiones: los resultados indican una vulnerabilidad emocional en los estudiantes universitarios, con la existencia de una relación entre las afectividades negativas y un deterioro del rendimiento académico y de la perspectiva de futuro profesional. Objetivos postpandemia post pandemia COVID19 COVID 19 COVID-1 Métodos 202 2023 Depression 21 KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis 5 5% Resultados 58 depresión COVID19, 19, severo investigadas Conclusiones COVID1 1 COVID- 20 2
11.
Perianal Tuberculosis in an Immunocompetent Patient: Exploring the Uncommon Manifestation Patient
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Ferreira, Ana Rita
; Pereira, Hugo
; Castro, Bárbara
; Ferreira, Joana
; Esteves, Joana
; Pereira, Bela
; Vale, Sílvio
; Oliveira, Manuel
.
Abstract As it is an infrequent etiology, the diagnosis of perianal tuberculosis is challenging, especially in the absence of a pulmonary focus. TB should be considered in the differential diagnosis of perianal ulcers, fistulas, abscesses, mainly in non-healing and recurrent anal lesions. Treatment with anti-TB agents can provide complete recovery. Furthermore, these lesions are often diagnosed later after complete histopathological and mycobacterial results, where the benefit of avoiding morbid multiple surgeries by effective anti-TB treatment is lost. We reported a rare case of an immuno-competent patient with perianal TB, which was the first manifestation of the disease. A fit-and-well man in his 20s presented a large perianal abscess. Unexpectedly, his chest X-ray showed a rounded hyper-transparency in the left lung. The abscess was drained. Posterior investigation with culture analysis from pus swabs and sputum revealed the presence of Mycobacterium tuberculosis complex infection. After completing the 6 months of oral administration of anti-TB drugs, the patient was asymptomatic. By highlighting this unusual manifestation, we aim to improve clinicians' awareness of perianal TB, facilitating early recognition and appropriate management. etiology challenging focus ulcers fistulas abscesses nonhealing non healing antiTB anti recovery Furthermore results lost immunocompetent immuno competent disease fitandwell fit well s Unexpectedly Xray X ray hypertransparency hyper transparency lung drained infection drugs asymptomatic clinicians management
12.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
13.
Impacto da pandemia da COVID-19 na doação de córnea e atuação do Banco de Olhos na Região da Zona da Mata Mineira COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Merola, Rafael Vidal
; Dias, Anna Marcella Neves
; Franco, Danielle Cristina Zimmermann
; Mendes, Nathália Barbosa do E. Santo
; Dias, Bárbara Carvalho
; Rocha, Erika Soares
; Candido, Giselle Moraes
; Oliveira, Jade Barbiéri de
; Almeida, Johann Dias Botelho de
; Castro, Nathália Carvalho
; Guimarães, Pedro Henrique Coelho
; Alves, Tarcísio Avancini
.
RESUMO Objetivo: Avaliar o impacto da pandemia da COVID-19 nas doações de córnea e na atuação de um banco de olhos na região da Zona da Mata Mineira. Métodos: Análise retrospectiva de prontuários de todas as doações obtidas pelo Banco de Olhos Hospital Regional Dr. João Penido, de Juiz de Fora (MG), entre 2017 e 2022, comparando-se os períodos pré (janeiro de 2017 a 11 de março de 2020) e pós-pandemia (12 de março de 2020 a dezembro de 2022). Resultados: Verificou-se uma redução nas doações de córnea e no número de tecidos corneanos liberados para transplantes no período pós pandemia, 68,2 e 67,3% respectivamente. Não houve diferença estatística no sexo, idade média, causa básica de óbito dos doadores, nos números de globos oculares não preservados e de córneas não preservadas entre os períodos pré e pós-pandemia. As taxas de liberação de córneas preservadas e aproveitamento das doações foram maiores no período pós-pandemia: 86,5 versus 79,0% e 68,1 versus 63,0%, respectivamente. O número de tecidos corneanos liberados para transplantes óptico e tectônico foram estatisticamente maiores no período pré-pandemia (p<0,001). Conclusão: A pandemia da COVID-19 impactou negativamente nas doações de córnea e na atuação do banco de olhos na região da Zona da Mata Mineira. Objetivo COVID19 COVID 19 COVID-1 Mineira Métodos Dr Penido MG, MG , (MG) 201 2022 comparandose comparando se janeiro 1 póspandemia 12 (1 202 2022. . 2022) Resultados Verificouse Verificou 682 68 2 68, 673 67 3 67,3 respectivamente sexo média doadores póspandemia. pandemia. 865 86 5 86, 790 79 0 79,0 681 630 63 63,0% prépandemia p<0,001. p0001 p p<0,001 001 (p<0,001) Conclusão COVID1 COVID- (MG 20 ( 6 67, 8 7 79, 63,0 p000 p<0,00 00 (p<0,001 63, p00 p<0,0 (p<0,00 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p
ABSTRACT Objective: To assess the impact of the COVID-19 pandemic on corneal donations and the operation of the eye bank in the Zona da Mata Mineira Region. Methods: Retrospective analysis of medical records of all donations obtained by the Banco de Olhos Hospital Regional Dr. João Penido/FHEMIG, Juiz de Fora - MG between 2017 and 2022, comparing pre (January/2017 – March 11/2020) and post-pandemic (12/March/2020 – December/2022) periods. Results: There was a reduction in cornea donations and the number of corneal tissues released for transplants in the post-pandemic period, 68.2% and 67.3%, respectively. There was no statistical difference in gender, average age, basic cause of death of donors, in the number of non-preserved eyeballs and non-preserved corneas between the pre- and post-pandemic periods. The rates of release of preserved corneas and use of donations were higher in the post-pandemic period, 86.5% vs 79.0%, and 68.1% vs 63.0%, respectively. The number of corneal tissues released for optical and tectonic transplants were statistically higher in the pre-pandemic period (P<0.001). Conclusion: The COVID-19 pandemic had a negative impact on cornea donations and the eye bank's operations in the Zona da Mata Mineira region. Objective COVID19 COVID 19 COVID-1 Region Methods Dr PenidoFHEMIG Penido FHEMIG Penido/FHEMIG 201 2022 January/2017 January2017 January (January/201 11/2020 112020 11 2020 postpandemic post 12/March/2020 12March2020 12 (12/March/202 December/2022 December2022 December periods Results 682 68 2 68.2 673 67 3 67.3% respectively gender age donors nonpreserved non 865 86 5 86.5 790 79 0 79.0% 681 1 68.1 630 63 63.0% prepandemic P<0.001. P0001 P P<0.001 . 001 (P<0.001) Conclusion banks s region COVID1 COVID- 20 202 January/201 January201 (January/20 11/202 11202 12/March/202 12March202 (12/March/20 December/202 December202 6 68. 67.3 8 86. 7 79.0 63.0 P000 P<0.00 00 (P<0.001 January/20 January20 (January/2 11/20 1120 12/March/20 12March20 (12/March/2 December/20 December20 67. 79. 63. P00 P<0.0 (P<0.00 January/2 January2 (January/ 11/2 112 12/March/2 12March2 (12/March/ December/2 December2 P0 P<0. (P<0.0 January/ (January 11/ 12/March/ 12March (12/March December/ P<0 (P<0. 12/March P< (P<0 (P< (P
14.
Development time and morphological characterization of immature stages of Nasonia vitripennis (Walker, 1836) (Hymenoptera: Pteromalidae) in host pupae of Chrysomya putoria (Wiedemann, 1830) (Diptera: Calliphoridae) Walker, Walker (Walker 1836 Hymenoptera (Hymenoptera Pteromalidae Wiedemann, Wiedemann (Wiedemann 1830 Diptera (Diptera Calliphoridae 183 18 1
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Proença, Barbara
; Ribeiro, Antonia de Castro
; Maia, Valéria Cid
; Couri, Márcia Souto
; Aguiar, Valéria Magalhães
.
ABSTRACT Nasonia vitripennis (Walker, 1836) (Hymenoptera: Pteromalidae) is a parasitoid involved in the biological control of several insects, including blow flies (Diptera, Calliphoridae) of economic importance. The aim of this study was to describe the morphological aspects of the immature stages of N. vitripennis and to record the postembryonic development time, using pupae of Chrysomya putoria (Wiedeman, 1830) as host. The experiment was conducted in a climatic chamber at 27°C/ day and 25°C/ night, with 60 ± 10% relative humidity and 14h photophase. Three experiment were conducted, each one with different host-parasitoid exposure times, of 12 hours, 16 hours and 24 hours respectively. In each experiment, the host:parasitoid relation applied was three host pupae of C. putoria to one parasitoid female. The experiment lasted 17 days, and it was used nine pupae per day totalizing 153 host pupae. The parasitoidism rate was 16.3% (12h), 40.5% (16h) and 94.1% (24h), respectively. The immature development duration of N. vitripennis with 16 and 24 hours of exposure, was as follows: egg stage (1st day), larvae (2nd to 6th day), prepupae (7th day), pupae (from 8th to 13th day) and pharate adult (14th day). The emergence of the adult parasitoids occurred on the 16th and 15th day with the exposure times of 16 and 24 hours, respectively. The exposure period of 24 hours was the ideal to observe the development time and to characterize the immature of N. vitripennis when compared to the 16 and 12 hours. Walker, Walker (Walker 1836 Hymenoptera (Hymenoptera Pteromalidae insects Diptera, Diptera (Diptera Calliphoridae importance N Wiedeman, Wiedeman (Wiedeman 1830 27C C 27 27°C 25C 25 25°C night 6 10 h photophase hostparasitoid 1 2 respectively female days 15 163 3 16.3 12h, 12h , (12h) 405 40 5 40.5 16h (16h 941 94 94.1 24h, 24h (24h) follows 1st st day, 2nd nd th 7th from 14th day. . 183 16. (12h 4 40. 9 94. (24h 18
15.
Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves
; Guimarães, Camila
; Rêgo, Jozelia
; Machado, Ketty Lysie Libardi Lira
; Miyamoto, Samira Tatiyama
; Burian, Ana Paula Neves
; Dias, Laiza Hombre
; Pretti, Flavia Zon
; Batista, Danielle Cristina Filgueira Alves
; Mill, José Geraldo
; Oliveira, Yasmin Gurtler Pinheiro de
; Gadelha, Carolina Strauss Estevez
; Gouveia, Maria da Penha Gomes
; Moulin, Anna Carolina Simões
; Souza, Bárbara Oliveira
; Aguiar, Laura Gonçalves Rodrigues
; Vieira, Gabriel Smith Sobral
; Grillo, Luiza Lorenzoni
; Lima, Marina Deorce de
; Pasti, Laís Pizzol
; Surlo, Heitor Filipe
; Faé, Filipe
; Moulaz, Isac Ribeiro
; Macabú, Mariana de Oliveira
; Ribeiro, Priscila Dias Cardoso
; Magalhães, Vanessa de Oliveira
; Aguiar, Mariana Freitas de
; Biegelmeyer, Erika
; Peixoto;, Flávia Maria Matos Melo Campos
; Kayser, Cristiane
; Souza, Alexandre Wagner Silva de
; Castro, Charlles Heldan de Moura
; Ribeiro, Sandra Lúcia Euzébio
; Telles, Camila Maria Paiva França
; Bühring, Juliana
; Lima, Raquel Lima de
; Santos, Sérgio Henrique Oliveira Dos
; Dias, Samuel Elias Basualto
; Melo, Natália Seixas de
; Sanches, Rosely Holanda da Silva
; Boechat, Antonio Luiz
; Sartori, Natália Sarzi
; Hax, Vanessa
; Dória, Lucas Denardi
; Rezende, Rodrigo Poubel Vieira de
; Baptista, Katia Lino
; Fortes, Natália Rodrigues Querido
; Melo, Ana Karla Guedes de
; Melo, Tâmara Santos
; Vieira, Rejane Maria Rodrigues de Abreu
; Vieira, Adah Sophia Rodrigues
; Kakehasi, Adriana Maria
; Tavares, Anna Carolina Faria Moreira Gomes
; Landa, Aline Teixeira de
; Costa, Pollyana Vitoria Thomaz da
; Azevedo, Valderilio Feijó
; Martins-Filho, Olindo Assis
; Peruhype-Magalhães, Vanessa
; Pinheiro, Marcelo de Medeiros
; Monticielo, Odirlei André
; Reis-neto, Edgard Torres Dos
; Ferreira, Gilda Aparecida
; Souza, Viviane Angelina de
; Teixeira-Carvalho, Andréa
; Xavier, Ricardo Machado
; Sato, Emilia Inoue
; Valim, Valeria
; Pileggi, Gecilmara Salviato
; Silva, Nilzio Antonio da
.
Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26
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