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ABSTRACT Objective Determining the etiology of hyperprolactinemia is fundamental for selecting the most appropriate treatment strategy. The aim of this study was to evaluate the usefulness and accuracy of prolactin levels in predicting the etiology of nonphysiological hyperprolactinemia. Subjects and methods In this retrospective study, we reviewed medical records of patients with nonphysiological hyperprolactinemia seen at two neuroendocrine reference centers located in Recife, Brazil, from January 2000 to December 2019. Results The study included 770 patients aged 12-73 years (65% female). The three most frequent etiologies of hyperprolactinemia were prolactinomas (n = 263; 34.2%), drug-induced hyperprolactinemia (n = 160; 20.8%), and macroprolactinemia (n = 120; 15.6%). The highest mean prolactin levels were observed in cases of prolactinomas and idiopathic hyperprolactinemia. Most patients with hyperprolactinemia due to other etiologies had prolactin levels < 100 ng/mL, but these levels were also found in 16.5% of patients with microproplactinomas and in 20% of those with idiopathic hyperprolactinemia. Likewise, prolactin levels largely overlapped among patients with microprolactinomas, macroprolactinemia, and drug-induced hyperprolactinemia. Notably, prolactin levels > 250 ng/mL enabled a clear distinction between the etiologies of macroprolactinoma and nonfunctioning pituitary adenoma. Moreover, prolactin levels > 500 ng/mL were highly suggestive of macroprolactinomas, although they were also found in very few patients (<2%) with microprolactinomas or drug-induced hyperprolactinemia. Conclusion Despite considerable overlap in prolactin levels among the different etiologies of hyperprolactinemia, values > 250 ng/mL allowed a clear distinction between macroprolactinomas and nonfunctioning pituitary adenomas. Furthermore, prolactin levels > 500 ng/mL were almost exclusively found in patients with prolactinomas. strategy Recife Brazil 200 2019 77 1273 12 73 12-7 65% 65 (65 female. female . female) n 263 34.2%, 342 34.2% , 34 2 34.2%) druginduced drug induced 160 20.8%, 208 20.8% 20 8 20.8%) 120 15.6%. 156 15.6% 15 6 15.6%) 10 ngmL ng mL 165 16 5 16.5 Likewise Notably 25 adenoma Moreover 50 <2% (<2% adenomas Furthermore 201 7 127 1 12- (6 26 34.2 3 20.8 15.6 16. <2 (<2 ( 34. 20. 15. (<

https://doi.org/10.20945/2359-4292-2023-0391

Identifying necessary conditions to deep-tech entrepreneurship deeptech deep tech
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Dionisio, Eduardo Avancci

; Inacio Junior, Edmundo

; Morini, Cristiano

; Carvalho, Ruy de Quadros

RAUSP Management Journal

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jun 2023, Volume 58 N. 2 Pages 162 - 185

Abstract: En | Text: En | PDF: En

Abstract Purpose This paper aims to address which resources provided by an entrepreneurial ecosystem (EE) are necessary for deep technology entrepreneurship. Design/methodology/approach The authors used a novel approach known as necessary condition analysis (NCA) to data on EEs and deep-tech startups from 132 countries, collected in a global innovation index and Crunchbase data sets. The NCA makes it possible to identify whether an EEs resource is a necessary condition that enables entrepreneurship. Findings Necessary conditions are related to political and business environment; education, research and development; general infrastructure; credit; trade; diversification and market size; and knowledge absorption capacity. Research limitations/implications The results show that business and political environments are the most necessary conditions to drive deep-tech entrepreneurship. Practical implications Policymakers could prioritize conditions that maximize entrepreneurial output levels rather than focusing on less necessary elements. Social implications Some resources require less performance than others. So, policymakers should consider allocating policy efforts to strengthen resources that maximize output levels. Originality/value Studies on deep-tech entrepreneurship are scarce. This study provides a bottleneck analysis that can guide the formulation of policies to support deep-tech entrepreneurship, as it allows to identify priority areas for resource allocation. EE (EE Designmethodologyapproach Design methodology (NCA deeptech tech 13 countries sets environment education development infrastructure credit trade size capacity limitationsimplications limitations elements others So Originalityvalue Originality value scarce allocation 1

https://doi.org/10.1108/rausp-09-2022-0203

Treatment of experimentally induced partial-thickness burns in rats with different silver-impregnated dressings
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Carvalho, Carolyna de Sousa

; Bernardes, Milton Junio Cândido

; Gonçalves, Randys Caldeira

; Vilela, Marielle Sousa

; Silva, Marcus Vinicius Meneses da

; Oliveira, Vinicius da Silva

; Rocha, Marcelo Ribeiro da

; Vinaud, Marina Clare

; Galdino Junio, Hélio

; Lino Junior, Ruy de Souza

Acta Cirúrgica Brasileira

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2022, Volume 37 N. 8 elocation e370801

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To evaluate the morphometric, macroscopic and microscopic aspects of experimentally induced partial-thickness burns in rats treated with different silver-based dressings. Methods: Wistar rats were used, divided into six treatments: saline (NaCl 0.9%); silver sulfadiazine 1%; Silvercel; Mepilex Ag; Aquacel Ag and Acticoat. The animals were monitored daily and euthanized at 7, 14 and 30 days after injury induction (DAI). Results: At 7 DAI, necrosis/crust was greater in control, silver sulfadiazine and Mepilex Ag treatments, granulation tissue was induced by Aquacel Ag, polymorphonuclear infiltrate (PMN) infiltration was intensified by Mepilex Ag; mononuclear infiltrate (MN) infiltration and angiogenesis were increased by Silvercel. At 14 DAI, hemorrhage was decreased by Silvercel and Mepilex Ag, PMN infiltration increased by Acticoat. At 30 DAI, angiogenesis was greater in the Acticoat treatment and fibroblasts were increased by Acticoat and Mepilex Ag. Collagen was induced at 14 DAI by silver sulfadiazine and Aquacel Ag and, at 30 DAI, by silver sulfadiazine and Silvercel treatments. Conclusions: Silvercel and Acticoat presented better results than the other products. However, all the dressings were better than the control at some point during the process, and may contribute to the healing of partial thickness burns. Silvercel and Aquacel Ag treatments induced better cosmetic outcomes regarding wound closure and scarring.

https://doi.org/10.1590/acb370801

Effective temperature for overcoming dormancy of ‘Fuyu’ persimmon tree buds
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Pereira, Gabriely Pinto

; Francisco, Felipe

; Biasi, Luiz Antonio

; Carvalho, Ruy Inácio Neiva de

; Zanette, Flávio

Arquivos do Instituto Biológico

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2022, Volume 89 elocation e00012021

Abstract: En | Text: En | PDF: En

ABSTRACT The objective of this study was to evaluate the effective temperature for overcoming the dormancy of ‘Fuyu’ persimmon tree buds. Stem samples were collected three times between 2013 and 2014. Stems were maintained in a climate incubator chamber at 3, 6, 9, and 12 °C. For each temperature, five numbers of additional chilling hours (CH) (0, 240, 384, 528, and 672 CH) were studied. The experimental design was completely randomized in a 5 × 4 factorial design (chilling hours × temperatures) with four replications with 10 cuttings. The maintenance of branches at cold temperatures from 3 to 12 °C intensified endodormancy of the buds when the plants were at the beginning of endodormancy. The most effective temperatures for overcome dormancy when the buds were in transition from paradormancy to endodormancy were from 3 to 6 °C. When the buds were already in endodormancy, temperatures of 3, 6, 9, and 12 °C were effective for the accumulation of cold and overcoming dormancy. The increase in the number of chilling hours from 3 to 12 °C induced budburst and the temperature of 12 °C was able to slowly induce and overcome bud dormancy.

https://doi.org/10.1590/1808-1657000012021

Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats
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Bernardes, Milton Junior Cândido

; Gonçalves, Randys Caldeira

; Carvalho, Carolyna de Sousa

; Rosa, Luciana Martins

; Ferreira, Amanda Peixoto

; Vilela, Marielle Sousa

; Vinaud, Marina Clare

; Galdino Junior, Hélio

; Lino Junior, Ruy de Souza

Acta Cirúrgica Brasileira

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2022, Volume 37 N. 4 elocation e370401

Abstract: En | Text: En | PDF: En

ABSTRACT Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats. Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. The animals were followed during seven, 14 and 30 days after the injury induction. Morphometric, macroscopic and microscopic evaluations were performed. Results: The treatment with Dersani™ induced better results during the inflammatory and proliferative phases of the healing process (p<0.05). The animals treated with Safgel™ presented better scaring in the remodeling phase (p<0.05), and the treatment with Dersani™ and Solosite™ induced greater wound closure (p<0.05). Conclusions: The hydrogel-based dressings presented beneficial outcomes in the healing of burn wounds experimentally induced in rats due to their ability in maintain the humidity of the wound, in removing the exudate, in promoting cell migration and collagen production during the different phases of the healing process.

https://doi.org/10.1590/acb370401

Physiological and biochemical changes in ‘Fuyu’ persimmon buds during dormancy
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Pereira, Gabriely Pinto

; Francisco, Felipe

; Maia, Aline José

; Botelho, Renato Vasconcelos

; Biasi, Luiz Antonio

; Carvalho, Ruy Inacio Neiva de

; Zanette, Flávio

Ciência Rural

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2022, Volume 52 N. 1 elocation e20200955

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO: O objetivo deste trabalho foi identificar alterações fisiológicas e bioquímicas em gemas de caquizeiro ‘Fuyu’ durante a dormência. Ramos foram coletados entre março e agosto de 2015. A dormência foi avaliada pelo teste biológico de estacas de nós isolados, a 25 °C e fotoperíodo de 16 h. As variáveis analisadas foram umidade ponderal, teor de açúcares solúveis, atividade respiratória, atividade das enzimas superóxido dismutase (SOD), catalase (CAT), ascorbato peroxidase (APX), guaiacol peroxidase (POD) e polifenoloxidase (PPO), teor de peróxido de hidrogênio (H2O2) e peroxidação lipídica. No final de março de 2015 as plantas já estavam dormentes, as folhas e frutos presentes indicam efeito de paradormência. A indução da endodormência pode ter ocorrido em junho de 2015, quando iniciou acúmulo de horas de frio (HF) abaixo de 7,2 °C e maiores HF abaixo de 12 °C, que coincidiu com o período que houve diminuição da umidade e da atividade respiratória, aumento dos açúcares redutores, diminuição da atividade da SOD, CAT, APX e PPO e aumento de H2O2. Após acúmulo de 553 HF abaixo de 12 °C, a capacidade de brotação aumentou e as gemas apresentaram aumento da umidade, diminuição do teor de açúcares redutores, aumento da atividade respiratória, baixa atividade da SOD, CAT, APX e POD e elevados teores de H2O2.

ABSTRACT: This study identified physiological and biochemical changes in ‘Fuyu’ persimmon buds during dormancy. Branches were collected between March and August 2015. Dormancy was evaluated by biological testing of isolated node cuttings at 25 °C and a photoperiod of 16 h. The variables analyzed were water content; reducing sugar content; respiratory activity; activity of superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APX), guaiacol peroxidase (POD) and polyphenol oxidase (PPO) enzymes; hydrogen peroxide content (H2O2) and lipid peroxidation. At the end of March 2015, the plants were already dormant, and the leaves and fruits present indicated a paradormancy effect. Induction of endodormancy may have occurred in June 2015, when chilling hours (CH) below 7.2 °C and higher CH below 12 °C began to accumulate, which coincided with the period in which there was a decrease in water content and respiratory activity, an increase in reducing sugars, a decrease in SOD, CAT, APX and PPO and an increase in H2O2. After an accumulation of 553 CH below 12 °C, the budburst capacity increased, and the buds presented increased water content, decreased reducing sugars content, increased respiratory activity, low activity in SOD, CAT, APX and POD and high levels of H2O2.

https://doi.org/10.1590/0103-8478cr20200955 273 downloads

Implications for Clinical Practice from a Multicenter Survey of Heart Failure Management Centers
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Bocchi, Edimar Alcides

; Moreira, Henrique Turin

; Nakamuta, Juliana Sanajotti

; Simões, Marcus Vinicius

; Casas, Alberto de Almeida Las

; Costa, Altamiro Reis da

; Assis, Amberson Vieira de

; Durães, André Rodrigues

; Pereira-Barretto, Antonio Carlos

; Ravessa, Antonio Delduque de Araujo

; Macedo, Ariane Vieira Scarlatelli

; Biselli, Bruno

; Pinto, Carolina Maria Nogueira

; Filho, Conrado Roberto Hoffmann

; Costantini, Costantino Roberto

; Almeida, Dirceu Rodrigues

; Santos Jr, Edval Gomes dos

; Soliva Junior, Erwin

; Figueiredo, Estevão Lanna

; Albuquerque, Felipe Neves de

; Paulitsch, Felipe

; Neuenschwander, Fernando Carvalho

; Figueiredo Neto, José Albuquerque de

; Brito, Flavio de Souza

; Lopes, Heno Ferreira

; Villacorta, Humberto

; Souza Neto, João David de

; Sepulveda, João Mariano

; Ayoub, José Carlos Aidar

; Vilela-Martin, José F.

; Cardoso, Juliano Novaes

; Uemura, Laercio

; Moura, Lidia Zytynski

; Maia, Lilia Nigro

; Oliveira, Lucia Brandão de

; Maia, Lucimir

; Silva, Luís Beck da

; Gowdak, Luís Henrique Wolff

; Danzmann, Luiz Claudio

; Andrade, Marcus

; Braile-Sternieri, Maria Christiane Valeria Braga

; Moreira, Maria da Consolação Vieira

; França Neto, Olimpio R

; Filho, Otavio Rizzi Coelho

; Esteves, Paulo Frederico

; Raupp-da-Rosa, Priscila

; Silva, Ricardo Jorge de Queiroz e

; Mourilhe-Rocha, Ricardo

; Viégas, Ruy Felipe Melo

; Rassi, Salvador

; Mangili, Sandrigo

; Kaiser, Sergio Emanuel

; Martins, Silvia Marinho

; Kawabata, Vitor Sergio

Clinics

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2021, Volume 76 elocation e1991

Abstract: En | Text: En | PDF: En

OBJECTIVES: This observational, cross-sectional study based aimed to test whether heart failure (HF)-disease management program (DMP) components are influencing care and clinical decision-making in Brazil. METHODS: The survey respondents were cardiologists recommended by experts in the field and invited to participate in the survey via printed form or email. The survey consisted of 29 questions addressing site demographics, public versus private infrastructure, HF baseline data of patients, clinical management of HF, performance indicators, and perceptions about HF treatment. RESULTS: Data were obtained from 98 centers (58% public and 42% private practice) distributed across Brazil. Public HF-DMPs compared to private HF-DMP were associated with a higher percentage of HF-DMP-dedicated services (79% vs 24%; OR: 12, 95% CI: 94-34), multidisciplinary HF (MHF)-DMP [84% vs 65%; OR: 3; 95% CI: 1-8), HF educational programs (49% vs 18%; OR: 4; 95% CI: 1-2), written instructions before hospital discharge (83% vs 76%; OR: 1; 95% CI: 0-5), rehabilitation (69% vs 39%; OR: 3; 95% CI: 1-9), monitoring (44% vs 29%; OR: 2; 95% CI: 1-5), guideline-directed medical therapy-HF use (94% vs 85%; OR: 3; 95% CI: 0-15), and less B-type natriuretic peptide (BNP) dosage (73% vs 88%; OR: 3; 95% CI: 1-9), and key performance indicators (37% vs 60%; OR: 3; 95% CI: 1-7). In comparison to non- MHF-DMP, MHF-DMP was associated with more educational initiatives (42% vs 6%; OR: 12; 95% CI: 1-97), written instructions (83% vs 68%; OR: 2: 95% CI: 1-7), rehabilitation (69% vs 17%; OR: 11; 95% CI: 3-44), monitoring (47% vs 6%; OR: 14; 95% CI: 2-115), GDMT-HF (92% vs 83%; OR: 3; 95% CI: 0-15). In addition, there were less use of BNP as a biomarker (70% vs 84%; OR: 2; 95% CI: 1-8) and key performance indicators (35% vs 51%; OR: 2; 95% CI: 91,6) in the non-MHF group. Physicians considered changing or introducing new medications mostly when patients were hospitalized or when observing worsening disease and/or symptoms. Adherence to drug treatment and non-drug treatment factors were the greatest medical problems associated with HF treatment. CONCLUSION: HF-DMPs are highly heterogeneous. New strategies for HF care should consider the present study highlights and clinical decision-making processes to improve HF patient care.

https://doi.org/10.6061/clinics/2021/e1991 870 downloads

Canine visceral leishmaniasis: perception, prevalence, and spatial distribution in municipality of Nossa Senhora do Livramento, Mato Grosso, Brazil
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Carvalho, Matheus Roberto

; Dias, Álvaro Felipe de Lima Ruy

; Almeida, Arleana do Bom Parto Ferreira de

; Alves, Mário Ribeiro

; Paes, Adilson Santos

; Sousa, Valéria Régia Franco

Revista Brasileira de Parasitologia Veterinária

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2020, Volume 29 N. 2 elocation e021019

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo No Brasil, a região Centro-Oeste tem apresentado aumento no número de casos de leishmaniose visceral humana (LVH) e canina (LVC). Com isso, o objetivo deste estudo foi avaliar a percepção da população em relação à doença, aos fatores associados a LVC, à distribuição espacial e à prevalência de anticorpos anti-Leishmania spp. em 385 cães, a partir do teste rápido imunocromatográfico e ensaio imunoenzimático (ELISA). Das 385 amostras, 54 foram reagentes para LVC e confirmadas no ELISA, correspondendo a prevalência de 14%. O conhecimento dos sinais da LVC pelos tutores (p = 0,038), a ocorrência prévia da LVC na vizinhança (p = 0,022), o cão sintomático (p = 0,014), esplenomegalia (p = 0,055) e apresentar úlcera em ponta de orelha (p = 0,059) foram significativamente associados à LVC. Os resultados demonstram expressiva prevalência de LVC, distribuídas espacialmente no contexto rural e urbano, e a associação de variáveis relacionadas ao ambiente e à percepção com a ocorrência da LVC ressaltam a importância da implementação de estratégias de controle e prevenção, focadas principalmente no manejo ambiental e em atividades de educação em saúde.

Abstract The midwest region of Brazil has witnessed an increase in the number of cases of human (HVL) and canine visceral leishmaniasis (CVL). The aim of the present study was to evaluate the population’s perception of these diseases, factors associated with CVL, its spatial distribution, and the prevalence of anti-Leishmania spp. in 385 dogs, determined using a commercially available immunochromatographic rapid test and confirmed using enzyme-linked immunosorbent assay (ELISA). Of the 385 samples, 54 were positive for CVL and confirmed by ELISA, corresponding to a prevalence of 14%. Knowledge of signs of CVL by tutors (p = 0.038); previous occurrence of CVL in the vicinity (p = 0.022); symptomatic dog(s) (p = 0.014), splenomegaly (p = 0.055), and ear ulcer(s) (p = 0.059) were significantly associated with CVL. The results revealed a significant prevalence of CVL spatially distributed in rural and urban contexts. The association between environmentally related variables and perception and the occurrence of CVL underscores the importance of implementing control and prevention strategies primarily focused on environmental management and health education activities.

https://doi.org/10.1590/s1984-29612020017 1046 downloads

Maturation, processing and seed storage of Elephantopus mollis Kunth
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Francisco, Felipe

; Pereira, Gabriely Pinto

; Carvalho, Ruy Inacio Neiva de

; Negrelle, Raquel Rejane Bonato

Acta Scientiarum. Agronomy

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2019, Volume 41 elocation e42628

Abstract: En | Text: En | PDF: En

ABSTRACT. Elephantopus mollis Kunth (Asteraceae) is an aromatic medicinal species native to South and Central America with hepatoprotective, anti-inflammatory, antitumor and leishmanicidal properties. We evaluated its maturation, ideal harvest moment, processing and seed storage, aiming to contribute to the production of this medicinal plant. We collected flower capitula between 7 and 56 days after anthesis for determination of seed moisture content, seed dry matter accumulation and germination, and correlated these factors with the morphological characters of the capitula. Capitulum processing was conducted with sieves and a seed blower to evaluate the purity, 1,000 seed weight, germination and cultural value of the seeds. The germination potential of seeds stored for 18 months refrigerated and at room temperature and the correlation of these results with those of an accelerated aging test were determined. The ideal harvest moment occurs at 49 days after anthesis and can be identified in the field by the brown coloration of the interfloral bracts. Seeds with cultural value above 80% can be obtained with the use of a 0.59 mm sieve and seed blower. The seeds can be stored cold for 12 months, and the accelerated aging test allows estimation of the viability of the seeds during storage for 18 months.

https://doi.org/10.4025/actasciagron.v41i1.42628 693 downloads

10.

Yield characteristics of cherry tomato cultivated with and without shading screen at different irrigation levels
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Santiago, Edgo Jackson Pinto

; Oliveira, Gertrudes Macário de

; Leitão, Mário de Miranda Vilas Boas Ramos

; Rocha, Ruy de Carvalho

; Pereira, Allan Victor Araújo

Pesquisa Agropecuária Tropical

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oct 2018, Volume 48 N. 4 Pages 374 - 381

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO O uso de tela de sombreamento no cultivo de hortaliças sensíveis ao excesso de radiação, associado ao uso eficiente de água via irrigação, possibilita ganhos de produtividade. Objetivou-se avaliar características de rendimento de tomate cereja cultivado com e sem o uso de tela de sombreamento e diferentes lâminas de irrigação. Utilizou-se delineamento em blocos casualizados, em esquema fatorial 4 x 2, com quatro lâminas de irrigação (140 %, 160 %, 180 % e 200 % da evapotranspiração de referência - ETo) e dois híbridos de tomate cereja (Wanda e Dolcetto). A lâmina de irrigação correspondente a 200 % da ETo proporcionou maiores valores para número de flores e cachos formados, número de frutos por planta e diâmetro de fruto. O híbrido Wanda foi mais frutífero, com maior emissão de cachos, enquanto o Dolcetto mostrou-se mais florífero. O uso de tela de sombreamento no cultivo de tomate cereja proporciona incremento nas características de rendimento, se comparado ao cultivo em áreas abertas.

ABSTRACT The use of shading screen in vegetable crops sensitive to the radiation excess, associated with the effective water use via irrigation, allows for yield gains. This study aimed to evaluate the yield characteristics of cherry tomato cultivated with and without shading screen and different irrigation levels. A randomized block design was used, in a 4 x 2 factorial arrangement, with four irrigation levels (140 %, 160 %, 180 % and 200 % of the reference evapotranspiration - ETo) and two cherry tomato hybrids (Wanda and Dolcetto). The irrigation level corresponding to 200 % of the ETo provided the highest values for number of flowers and clusters formed, number of fruits per plant and fruit diameter. The Wanda hybrid was more fruitful, with a higher emission of clusters, while Dolcetto was more floriferous. The use of shade screen for cultivating cherry tomato provides an increase in the yield characteristics, if compared to the cultivation in open areas.

https://doi.org/10.1590/1983-40632018v4853064 837 downloads

11.

Potencial of different hydroxyapatites as biomaterials in the bone remodeling
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Cassino, Pedro Carvalho

; Rosseti, Larissa Schimidt

; Ayala, Osmar Ignácio

; Martines, Marco Antônio Utrera

; Portugual, Luciane Candeloro

; Oliveira, Claudio Goncalves de

; Silva, Iandara Schettert

; Caldas, Ruy de Araujo

Acta Cirúrgica Brasileira

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sep 2018, Volume 33 N. 9 Pages 816 - 823

Abstract: En | Text: En | PDF: En

Abstract Purpose: To analyze the therapeutic potentials of different hydroxyapatites used for the correction of bone defects in rats. Methods: Forty rats, male, albino wistar, were distributed in 4 groups. They were submitted to a 3.5 mm defect in tibia. They received low purity hydroxyapatite, Strontium hydroxyapatite and hydroxyapatite doped with gallium, having a seven day evaluation time. Histopathology slides were stained with hematoxylin-eosin, for morphological evaluation. Were analyzed inflammatory processes, necrosis, presence of osteoclasts and osteoblasts, presence of the material, presence of white cells, neovascularization and bone neoformation. Results: It was observed that the groups HAPSr and HAPGa, presented better results of trabecular bone, hyaline cartilage and bone marrow more organized. Conclusion: There was improvement in the repair of the bone defect produced, showing that these hydroxyapatites are effective osteoinductive, osteoconductive, osteintegrant agents and have biocompatibility, and may be indicated for use in defect repairs.

https://doi.org/10.1590/s0102-865020180090000010 1048 downloads

12.

Colorectal adenocarcinoma staging of patients in a public tertiary hospital in the state of Grande do Sul
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Berg, Elias de Mattos

; Ruszczyk, Juliana Vasconcelos de Abreu

; Moschetti, Laura

; Carvalho, Luciano Pinto de

; Koshimizu, Ruy Takashi

; Koppe, Daniela Cerqueira

Journal of Coloproctology (Rio de Janeiro)

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sep 2018, Volume 38 N. 3 Pages 221 - 226

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Introdução: O câncer colorretal tem a segunda maior prevalência e a terceira maior incidência no mundo. A mortalidade está diretamente relacionada ao estágio da doença. Objetivo: Avaliar o estadiamento de pacientes com adenocarcinoma colorretal atendidos pelo Serviço de Coloproctologia do Hospital Nossa Senhora da Conceição (HNSC) entre os anos de 2010 e 2015. Método: Estudo de prevalência. A coleta de dados foi realizada de forma retrospectiva através de pesquisa no sistema eletrônico do Grupo Hospitalar Conceição buscando todos os pacientes com CID 10 C18, C19 e C20 atendidos pelo serviço de Coloproctologia entre os anos de 2010 e 2015. Resultados: Foram elegíveis para o estudo 420 pacientes. A média de idade foi de 65,6 anos (±12,8). Quanto ao estadiamento, observamos a seguinte distribuição: 7,9% estágio I; 23,6% estágio II; 37,6% estágio III e 30,2% estágio IV. O percentual de pacientes com adenocarcinoma colorretal avançado (estágio III + estágio IV) é de 67,8%. Em relação à origem, 51% dos pacientes foram atendidos através da emergência. Conclusão: A maioria dos pacientes atendidos neste hospital apresenta doença avançada (67%) e são oriundos do serviço de emergência (51%).

ABSTRACT Introduction: Colorectal cancer has the second highest prevalence and the third highest incidence in the world. Mortality is directly related to the stage of the disease. Objective: To evaluate the staging of patients with colorectal adenocarcinoma treated at the Coloproctology Department of the Hospital Nossa Senhora da Conceição between 2010 and 2015. Method: Prevalence study. Data collection was performed retrospectively through a survey in the electronic system of the Hospital Group Conceição, seeking all patients with ICD 10 C18, C19 and C20 who were attended at the Coloproctology Department between 2010 and 2015. Results: Four hundred and twenty patients were eligible for the study. The mean age was 65.6 years (±12.8). Regarding staging, we observed the following distribution: 7.9%, stage I; 23.6%, stage II; 37.6%, stage III; and 30.2%, stage IV. The percentage of patients with advanced colorectal adenocarcinoma (stage III + stage IV) is 67.8%. Regarding the origin, 51% of the patients were attended at the emergency department. Conclusion: Most patients treated at this hospital have advanced disease (67%) and come from the emergency department (51%).

https://doi.org/10.1016/j.jcol.2018.05.003 607 downloads

13.

Model for Multiple Imputation to Estimate Daily Rainfall Data and Filling of Faults
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de Carvalho, José Ruy Porto

; Almeida Monteiro, José Eduardo Boffinho

; Nakai, Alan Massaru

; Assad, Eduardo Delgado

Revista Brasileira de Meteorologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

dec 2017, Volume 32 N. 4 Pages 575 - 583

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A modelagem por imputação múltipla com cadeias encadeadas é uma área de importância crescente cujos modelos e métodos têm sido muitas vezes desenvolvidos para lidar com aplicações específicas. No presente estudo, o modelo de imputação múltipla foi utilizado para estimar os dados de precipitação diária. Foram utilizados registros de precipitação de várias estações meteorológicas, obtidos a partir do sistema Agritempo para duas zonas climaticamente homogéneas. Os valores de precipitação obtidos para duas datas fixas (02 de Maio de 2005 e 20 de Janeiro de 2005) usando o modelo de imputação múltipla foram comparados com as técnicas geoestatisticas de krigagem ordinária e cokrigagem ordinária com a altitude como variável auxiliar. O modelo de imputação múltipla foi mais de 16% melhor para a primeira Zona e mais de 23% melhor para a segunda zona, comparadas com as estimativas de precipitação obtidas pelas técnicas geoestatísticas. O modelo provou ser uma técnica versátil, com resultados coerentes com as condições de diferentes zonas e épocas.

Abstract Modeling by multiple enchained imputation is an area of growing importance. However, its models and methods are frequently developed for specific applications. In this study the model for multiple imputation was used to estimate daily rainfall data. Daily precipitation records from several meteorological stations were used, obtained from system AGRITEMPO for two homogenous climatic zones. The precipitation values obtained for two dates (Jan. 20th 2005 and May 2nd 2005) using the multiple imputation model were compared with geo-statistics techniques ordinary Kriging and Co-kriging with the altitude as an auxiliary variable. The multiple imputation model was 16% better for the first zone and over 23% for the second one, compared to the rainfall estimation obtained by geo-statistical techniques. The model proved to be a versatile technique, presenting coherent results with the conditions of different zones and times.

https://doi.org/10.1590/0102-7786324006 1957 downloads

14.

Effects that passive cycling exercise have on muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients: a randomized clinical trial
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Machado, Aline dos Santos

; Pires-Neto, Ruy Camargo

; Carvalho, Maurício Tatsch Ximenes

; Soares, Janice Cristina

; Cardoso, Dannuey Machado

; Albuquerque, Isabella Martins de

Jornal Brasileiro de Pneumologia

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- Sobre o periódico
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apr 2017, Volume 43 N. 2 Pages 134 - 139

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Avaliar os efeitos da realização de exercícios passivos com um cicloergômetro, associada à fisioterapia convencional, na força muscular periférica, no tempo de ventilação mecânica e no tempo de internação hospitalar em pacientes críticos internados em UTI de um hospital universitário terciário. Métodos: Ensaio clínico randomizado envolvendo 38 pacientes (idade > 18 anos) em ventilação mecânica e divididos aleatoriamente em grupo controle (n = 16), que realizou fisioterapia convencional, e grupo intervenção (n = 22) submetidos a fisioterapia convencional e exercícios passivos em cicloergômetro cinco vezes por semana. A média de idade dos pacientes foi de 46,42 ± 16,25 anos, e 23 eram homens. Os desfechos analisados foram força muscular periférica, mensurada pela escala Medical Research Council, tempo de ventilação mecânica e tempo de internação hospitalar. Resultados: Houve um aumento significativo da força muscular periférica (basal vs. final) tanto no grupo controle (40,81 ± 7,68 vs. 45,00 ± 6,89; p < 0,001) quanto no grupo intervenção (38,73 ± 11,11 vs. 47,18 ± 8,75; p < 0,001). Entretanto, a variação do aumento da força foi maior no grupo intervenção que no controle (8,45 ± 5,20 vs. 4,18 ± 2,63; p = 0,005). Não foram observadas diferenças significativas entre os grupos quanto ao tempo de ventilação mecânica e tempo de internação hospitalar. Conclusões: Os resultados sugerem que a realização de mobilização passiva contínua de forma cíclica auxilia na recuperação da força muscular periférica de pacientes internados em UTI. (ClinicalTrials.gov Identifier: NCT01769846 [http://www.clinicaltrials.gov/])

ABSTRACT Objective: To evaluate the effects that passive cycling exercise, in combination with conventional physical therapy, have on peripheral muscle strength, duration of mechanical ventilation, and length of hospital stay in critically ill patients admitted to the ICU of a tertiary care university hospital. Methods: This was a randomized clinical trial involving 38 patients (≥ 18 years of age) on mechanical ventilation who were randomly divided into two groups: control (n = 16), receiving conventional physical therapy; and intervention (n = 22), receiving conventional physical therapy and engaging in passive cycling exercise five days per week. The mean age of the patients was 46.42 ± 16.25 years, and 23 were male. The outcomes studied were peripheral muscle strength, as measured by the Medical Research Council scale, duration of mechanical ventilation, and length of hospital stay. Results: There was a significant increase in peripheral muscle strength (baseline vs. final) in both groups (control: 40.81 ± 7.68 vs. 45.00 ± 6.89; and intervention: 38.73 ± 11.11 vs. 47.18 ± 8.75; p < 0.001 for both). However, the range of increase in strength was higher in the intervention group than in the control group (8.45 ± 5.20 vs. 4.18 ± 2.63; p = 0.005). There were no significant differences between the groups in terms of duration of mechanical ventilation or length of hospital stay. Conclusions: The results suggest that the performance of continuous passive mobilization on a cyclical basis helps to recover peripheral muscle strength in ICU patients. (ClinicalTrials.gov Identifier: NCT01769846 [http://www.clinicaltrials.gov/])

https://doi.org/10.1590/s1806-37562016000000170 18638 downloads

15.

Spatio-Temporal Modeling of Data Imputation for Daily Rainfall Series in Homogeneous Zones
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Carvalho, José Ruy Porto De

; Nakai, Alan Massaru

; Monteiro, José Eduardo B.A.

Revista Brasileira de Meteorologia

Journal Metrics
- Sobre o periódico
- SciELO Analytics

jun 2016, Volume 31 N. 2 Pages 196 - 201

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A modelagem espaço-temporal é uma área de importância crescente em que modelos e métodos têm sido desenvolvidos para aplicações específicas. Neste estudo, o modelo espaço-temporal foi utilizado na estimativa de dados de precipitação diários. Foram utilizados dados provenientes dos registros pluviométricos de diversas estações meteorológicas, obtidos junto Sistema Agritempo para duas zonas climaticamente homogêneas. Valores de chuva para duas datas fixas (01 de janeiro de 2012 e 01 de maio de 2012) estimados pelo modelo espaço-temporal foram comparados com as técnicas geoestatísticas de krigagem e cokrigagem ordinária, com altitude como variável auxiliar. O modelo espaço-temporal foi superior em mais de 17% em relação às técnicas geoestatísticas de krigagem e cokrigagem para produzir estimativas da precipitação diária para a primeira zona homogênea e mais de 18% para a segunda zona homogênea. O modelo espaço-temporal provou ser uma técnica versátil, adaptando-se nas diferentes épocas e datas estudadas.

Abstract Spatio-temporal modelling is an area of increasing importance in which models and methods have often been developed to deal with specific applications. In this study, a spatio-temporal model was used to estimate daily rainfall data. Rainfall records from several weather stations, obtained from the Agritempo system for two climatic homogeneous zones, were used. Rainfall values obtained for two fixed dates (January 1 and May 1, 2012) using the spatio-temporal model were compared with the geostatisticals techniques of ordinary kriging and ordinary cokriging with altitude as auxiliary variable. The spatio-temporal model was more than 17% better at producing estimates of daily precipitation compared to kriging and cokriging in the first zone and more than 18% in the second zone. The spatio-temporal model proved to be a versatile technique, adapting to different seasons and dates.

https://doi.org/10.1590/0102-778631220150025 1868 downloads

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