Abstract Endometriosis is a chronic disease, characterized by the presence of endometrium outside the uterine cavity, which affects around 10% of women of reproductive age. Symptoms vary widely and can be absent or severe, debilitating and highly restrictive of quality of life. Pain, in different forms, intensities and associations, is the most striking symptom. The endometriosis is often associated with infertility and other comorbidities that represent additional risks for patients. Diagnosing is a major challenge. It is often delayed, for reasons rooted in the unspecific nosology of the disease, which is confused with common conditions. Another major challenge is treatment, since it is a chronic, multifaceted disease, sometimes with systemic repercussions, for which it is essential to find a personalized response. This review highlights the most recent aspects of pathogenesis and treatment options, particularly the new pharmacological options with GnRH antagonists, reserving surgery for specific situations. New molecular agents are being developed for the diagnosis and potential treatment of this disease. The configuration of clinical guidelines for optimizing the fertility potential of these patients remains to be defined.

Resumo A endometriose é uma doença crónica, caracterizada pela presença de endométrio fora da cavidade uterina, que afeta cerca de 10% das mulheres em idade reprodutiva. A sua expressão sintomática é muito variada, pode estar ausente ou ser grave, debilitante e altamente condicionante da qualidade de vida. A dor, com matizes e associações diversas, é o sintoma mais marcante. Associa-se com frequência a infertilidade e outras comorbilidades que representam riscos adicionais para as doentes. O diagnóstico da endometriose é um grande desafio. O atraso é frequente, por razões que radicam na nosologia pouco especifica da doença, que se confunde com situações comuns. Outro grande desafio é o tratamento, uma vez que é uma doença crónica, multifacetada, por vezes com repercussão sistémica, para a qual é indispensável encontrar uma resposta personalizada. Esta revisão destaca os aspetos mais recentes da patogénese e opções do tratamento, nomeadamente as novas opções farmacológicas com antagonistas da GnRH, reservando a cirurgia para situações específicas. Estão em desenvolvimento novos agentes moleculares para o diagnóstico e potencial tratamento desta doença. A configuração de orientações clínicas para a otimização do potencial de fertilidade dessas doentes continua por definir.

RESUMEN El apoyo social es una dimensión esencial para romper las dificultades de participación social de los estudiantes con discapacidad. El objetivo del presente estudio fue conocer la perspectiva de estudiantes con incapacidad auditiva, visual, física o motora y dificultades específicas de aprendizaje sobre lo que consideran suporte social. Con este fin, se desenrolló un estudio cualitativo con 15 estudiantes de 3.º a 12.º grado (8 a 18 años de edad). Las entrevistas semiestructuradas fueron analizadas a partir de categorías previamente definidas; de los datos surgieron subcategorías. Los estudiantes valoraron la disponibilidad de sus compañeros y maestros para apoyarlos e involucrarlos en las actividades de clase y la expresión de empatía y cuidado. También se refirieron a situaciones de rechazo y exclusión. El artículo discute condiciones que favorecen el conocimiento del otro y una cultura de suporte social recíproco, esencial para facilitar la participación social.

ABSTRACT Social support is essential for overcoming the difficulties that students with special educational needs face in interacting with peers. The goal of the study was to explore the perspective of students presenting with hearing, visual and physical or motor deficiencies and specific learning difficulties about what they consider to be social support. To this end, we developed a qualitative study. Semi-structured interviews were conducted with 15 students (3rd to the 12th grade; 8 to 18 years old). Answers were analyzed from previously defined categories, subcategories emerged from the data. Students valued the availability of their classmates and teachers to support and involve them in class activities, as well as expressions of empathy, care and attention. Students mentioned situations of rejection and exclusion. The paper discusses conditions that favor mutual knowledge and a culture of reciprocal social support, both of which are essential to facilitate students’ social participation.

RESUMO O suporte social permite quebrar dificuldades de participação social de alunos com necessidades educativas específicas. O objetivo do estudo foi conhecer a perspetiva de alunos com deficiência auditiva, visual, físico-motora e dificuldades específicas de aprendizagem sobre o que consideram ser suporte social. Para tal, foi desenvolvido um estudo de natureza qualitativa. Foram realizadas entrevistas semiestruturadas a 15 alunos com estas condições (do 3.º ao 12.º, com idades entre os 8 e 18 anos). As respostas foram analisadas a partir de categorias previamente definidas, tendo emergido um conjunto de subcategorias a partir dos dados. Os alunos valorizaram a disponibilidade dos seus colegas e professores para os apoiar e os envolver nas atividades da turma e a expressão de empatia e cuidado. Referiram também situações de rejeição e exclusão. No artigo são discutidas condições que favorecem o conhecimento do outro e uma cultura de suporte social recíproco, essenciais para a participação social.

Abstract Medical communication skills are treated as innate abilities, without the need for training and evaluation. However, they play a very important role in the doctor-patient relationship. Communication deficits are a cause of dissatisfaction and litigation. Quality communication is associated with greater adherence to proposed procedures and increases patient satisfaction and safety. Effective communication is particularly important in Gynecology-Obstetrics and justifies specific training. Formal teaching of communication skills should be included at all levels of medical education, just like technical-scientific skills.

Resumo As capacidades comunicacionais dos médicos são tratadas como habilidades inatas, sem a necessidade de treino e avaliação. Desempenham, no entanto, um papel da maior importância na relação médico-doente. Os déficits de comunicação são causa de descontentamento e motivo de litigância. A comunicação de qualidade está associada a maior adesão aos procedimentos propostos, aumenta a satisfação e segurança do doente. A comunicação eficaz assume particular acutilância em Ginecologia-Obstetrícia e justifica que seja objeto de treino específico. O ensino formal da competência em comunicação deve ser incluído em todos os níveis da educação médica, à semelhança das competências técnico-científicas.

RESUMO Este trabalho de natureza reflexiva tem o propósito de realizar uma abordagem do estatuto epistemológico da Administração Educacional baseada nos principais contributos para a sua afirmação como disciplina autônoma, identificando alguns aspetos que dificultam e alavancam o seu entendimento como ciência. Realizamos uma abordagem a alguns aspetos explicativos para a recente biografia da designação de Administração Educacional, não deixando de identificar o modo como o conceito se estabelece em contexto português, e fazemos referência às suas dimensões técnica e política, dando conta da relação de dependência que entre elas se estabelece, muito embora existam perspetivas que enfatizam cada uma das dimensões em prejuízo da outra. autônoma ciência português política outra

ABSTRACT This reflective work addresses the epistemological status of Educational Administration from the main contributions to its affirmation as an autonomous discipline, identifying some aspects that hinder and leverage its understanding as a science. We approach some explanatory aspects for the recent biography of the designation of Educational Administration, while identifying the way in which the concept is established in the Portuguese context and referring to its technical and political dimensions, giving an account of the relationship of dependence that holds between them, although there are perspectives that emphasize each dimension to the detriment of the other. discipline science dimensions them other

RESUMEN Este trabajo reflexivo pretende reflexionar sobre el estatus epistemológico de la Administración Educativa a partir de los principales aportes a su afirmación como disciplina autónoma, identificando algunos aspectos que dificultan y apalancan su comprensión como ciencia. Abordamos algunos aspectos explicativos de la biografía reciente de la designación de Administración Educativa, identificando la forma en que el concepto se establece en el contexto portugués y haciendo referencia a sus dimensiones técnicas y políticas, dando cuenta de la relación de dependencia que entre establecidas, aunque hay perspectivas que enfatizan cada dimensión en detrimento de la otra. autónoma ciencia políticas establecidas otra

RESUMO Objetivo: construir e validar o conteúdo de um Bundle para transição alimentar para prematuros internados na Unidade de Cuidados Intermediários Canguru baseada na Teoria Interativa de Amamentação. Método: Pesquisa do tipo método múltiplos realizada em cinco etapas: Revisão Sistemática; Diagnóstico Situacional; Entrevista com Enfermeiras da Unidade Canguru; Etapa Metodológica - (Construção do Bundle com aplicação da Teoria Interativa de Amamentação, Pré-teste) e por última, a validação de conteúdo com juízes expertises e enfermeiras assistenciais. A etapa metodológica, foi realizada de janeiro a julho de 2022, com enfermeiras da Unidade Canguru, de uma Maternidade pública de Fortaleza-CE, já os expertises foram convidados por e-mail, pelo método de bola de neve. A validação ocorreu mediante Índice de Validade de Conteúdo >0,80. Resultados: A construção do Bundle ocorreu partindo de 13 itens, distribuídos e organizados em grupos de idade corrigida: idade corrigida de ≤32 semanas; entre 32 a 34 semanas e ≥ 34 semanas. Na etapa de validação, os juízes, três expertises e sete enfermeiras assistenciais, julgaram adequado o Bundle, apresentando Índice de Validade de Conteúdo de 1,0. Conclusão: diante da inexistência de padronização para transição alimentar na prática clínica, existe uma dificuldade para o reconhecimento do momento ideal em realizar a transição da alimentação da sonda orogástrica para o peito materno. O Bundle de Transição Alimentar, ancorado pela Teoria Interativa de Amamentação, possibilita que o enfermeiro avalie o binômio mãe-filho, suas particularidades, tempo de ambos, protagonismo materno, envolvendo os sistemas organizacionais de proteção, promoção e apoio a amamentação. Registro Brasileiro de Ensaios Clínicos (REBEC) sob número UTN: U1111-1285-3181. Objetivo Amamentação Método etapas Sistemática Situacional Construção Préteste Pré teste Pré-teste última assistenciais metodológica 2022 FortalezaCE, FortalezaCE Fortaleza CE, CE Fortaleza-CE email, email mail, mail e-mail neve 080 0 80 >0,80 Resultados 1 itens ≤3 3 10 1,0 Conclusão clínica materno Alimentar mãefilho, mãefilho mãe filho, filho mãe-filho particularidades ambos proteção amamentação REBEC (REBEC UTN U111112853181. U111112853181 U U1111 1285 3181. 3181 U1111-1285-3181 202 08 8 >0,8 ≤ 1, U11111285318 U111 128 318 U1111-1285-318 20 >0, U1111128531 U11 12 31 U1111-1285-31 2 >0 U111112853 U1 U1111-1285-3 > U11111285 U1111-1285- U1111128 U1111-1285 U111112 U1111-128 U11111 U1111-12 U1111-1 U1111-

ABSTRACT Objective: to construct and validate the content of a bundle for nutrition transition for premature newborns admitted to a Kangaroo Intermediate Care Unit based on Interactive Theory of Breastfeeding. Method: this is a multiple method research, carried out in five steps: systematic review; situational diagnosis; interview with Kangaroo Unit nurses; methodological step - (bundle construction with Interactive Theory of Breastfeeding application, pre-test); and content validity with expert judges and clinical nurses. The methodological step was carried out from January to July 2022 with Kangaroo Unit nurses of a public maternity hospital in Fortaleza-CE. Experts were invited by email using the snowball method. Validity occurred using a Content Validity Index >0.80. Results: the bundle was constructed using 13 items, distributed and organized into corrected age groups: corrected age of ≤32 weeks; from 32 to 34 weeks; and ≥ 34 weeks. In the validity step, the judges, three experts and seven clinical nurses, judged the bundle to be adequate, presenting a Content Validity Index of 1.0. Conclusion: given the lack of standardization for feeding transition in clinical practice, there is difficulty in recognizing the ideal moment to transition from orogastric tube feeding to mothers’ breast. The food transition bundle, anchored by the Interactive Theory of Breastfeeding, allows nurses to assess the mother-child dyad, their particularities, time for both, maternal role, involving organizational systems to protect, promote and support breastfeeding. Brazilian Clinical Trials Registry (REBEC) under UTN number: U1111-1285-3181. Objective Method research steps review diagnosis application pretest pre test pre-test) 202 FortalezaCE. FortalezaCE Fortaleza CE. CE Fortaleza-CE 080 0 80 >0.80 Results 1 items groups ≤3 weeks 3 adequate 10 1.0 Conclusion practice mothers breast motherchild mother child dyad particularities both role protect breastfeeding REBEC (REBEC number U111112853181. U111112853181 U U1111 1285 3181. 3181 U1111-1285-3181 pre-test 20 08 8 >0.8 ≤ 1. U11111285318 U111 128 318 U1111-1285-318 2 >0. U1111128531 U11 12 31 U1111-1285-31 >0 U111112853 U1 U1111-1285-3 > U11111285 U1111-1285- U1111128 U1111-1285 U111112 U1111-128 U11111 U1111-12 U1111-1 U1111-

RESUMEN Objetivo: construir y validar el contenido de un bundle de transición dietética para bebés prematuros admitidos en la Unidad de Cuidados Intermedios Canguro basado en la Teoría de la Lactancia Materna Interactiva. Métodos: se trata de una investigación de métodos múltiples realizada en cinco steps: revisión sistemática; diagnóstico situacional; entrevista con enfermeras de la Unidad Canguro; etapa metodológica - (construcción de bundle con aplicación de la Teoría de Lactancia Interactiva, pretest); y validez de contenido con jueces expertos y enfermeras clínicas. La etapa metodológica se realizó de enero a julio de 2022 con enfermeras de la Unidad Canguro de una maternidad pública de Fortaleza-CE. Se invitó a los expertos por correo electrónico utilizando el método de bola de nieve. La validación se produjo mediante el índice de validez de contenido >0,80. Resultados: el bundle se construyó utilizando 13 ítems, distribuidos y organizados en grupos de edad corregidos: edad corregida de ≤32 weeks; entre 32 a 34 semanas y ≥ 34 semanas. En la etapa de validez, los jueces, tres expertos y siete enfermeras clínicas, juzgaron adecuado el bundle, presentando un Índice de Validez de Contenido de 1,0. Conclusión: dada la falta de estandarización para la transición alimentaria en la práctica clínica, existe dificultad en reconocer el momento ideal para la transición de la alimentación por sonda orogástrica al pecho materno. El bundle de transición alimentaria, anclado en la Teoría Interactiva de la Lactancia Materna, permite a las enfermeras evaluar el binomio madre-hijo, sus particularidades, el tiempo de ambos, el rol materno, involucrando los sistemas organizacionales de protección, promoción y apoyo a la lactancia materna. Registro Brasileño de Ensayos Clínicos (REBEC) con el número UTN: U1111-1285-3181. Objetivo Métodos steps sistemática situacional construcción pretest pretest) clínicas 202 FortalezaCE. FortalezaCE Fortaleza CE. CE Fortaleza-CE nieve 080 0 80 >0,80 Resultados 1 ítems corregidos ≤3 weeks 3 10 1,0 Conclusión clínica materno madrehijo, madrehijo madre hijo, hijo madre-hijo particularidades ambos protección materna REBEC (REBEC UTN U111112853181. U111112853181 U U1111 1285 3181. 3181 U1111-1285-3181 20 08 8 >0,8 ≤ 1, U11111285318 U111 128 318 U1111-1285-318 2 >0, U1111128531 U11 12 31 U1111-1285-31 >0 U111112853 U1 U1111-1285-3 > U11111285 U1111-1285- U1111128 U1111-1285 U111112 U1111-128 U11111 U1111-12 U1111-1 U1111-

ABSTRACT Objective: To analyze the number of hospitalizations, the length of hospital stay, and mortality due to asthma, as well as the costs to the Unified Health Care System in Brazil between 2008 and 2021. Methods: This was a cross-sectional epidemiological study using data from the Information Technology Department of the Brazilian Unified Health Care System. Proportional hospitalization and death rates were estimated per 100,000 population by age, microregion, and year. Results: The number of hospitalizations and deaths due to asthma decreased from 2008 to 2021 (205,392 vs. 55,009 and 822 vs. 327, respectively). In addition, a between-sex difference was observed in asthma-related hospitalizations in 2008, and more men were hospitalized in 2021 (51.8%). Asthma mortality rates were similar for both sexes (50.0% each) in 2008, and a slight increase was observed in women’s deaths in 2021 (52.9%). Even so, approximately one death/day and more than 55,000 hospitalizations were observed yearly, with a mean length of hospital stay of three days. Additionally, the Southeast region allocated more financial resources to asthma-related hospitalizations. Conclusions: Our results showed that the number of deaths and hospitalizations due to asthma substantially declined during the study period. Objective 200 Methods crosssectional cross sectional 100000 100 000 100,00 age microregion year Results 202 205,392 205392 205 392 (205,39 vs 55009 55 009 55,00 82 327 respectively. respectively . respectively) addition betweensex sex asthmarelated related 51.8%. 518 51.8% 51 8 (51.8%) 50.0% 500 50 0 (50.0 each womens women s 52.9%. 529 52.9% 52 9 (52.9%) so deathday day 55000 yearly days Additionally Conclusions period 20 10000 10 00 100,0 205,39 20539 39 (205,3 5500 5 55,0 32 51.8 (51.8% 50.0 (50. 52.9 (52.9% 2 1000 1 100, 205,3 2053 3 (205, 550 55, 51. (51.8 50. (50 52. (52.9 205, (205 (51. (5 (52. (20 (51 ( (52 (2

The aim of this work was to extract and characterize pectin from lyophilized noni pulp (Morinda citrifolia Linn.) at three different pHs using different extractor agents and to evaluate anti-viral activity. The extraction of high yield (acid extraction) was subjected to sulfation procedure. Fourier transform infrared spectroscopy and proton nuclear magneticresonance analysis were used to calculate the degree of methylation of pectin from acid extraction and its sulfated derivative. The data obtained for the degree of methylation of noni pectin and sulfated pectin were 30.3 and 30.7, respectively. Pectin was subjected to acute oral toxicity testing in mice. The results showed that pectin had a pro-inflammatory effect, and sulfated pectin had an anti-inflammatory effect. Both pectins were also evaluated for herpes simplex virus activity in vitro, and although they successfully inhibited virus replication, the sulfated pectins were cytotoxic. Morinda Linn. Linn antiviral anti viral procedure derivative 303 30 3 30. 307 7 30.7 respectively mice proinflammatory pro inflammatory effect antiinflammatory vitro replication cytotoxic

Abstract Myeloid neoplasms result from molecular alterations in hematopoietic stem cells, with acute myeloid leukemia (AML) being one of the most aggressive and with a poor prognosis. Hematopoietic cell kinase (HCK) is a proto-oncogene that encodes a protein-tyrosine kinase of the Scr family, and it is highly expressed in AML. The present study investigated HCK expression in normal hematopoietic cells across myeloid differentiation stages and myeloid neoplasm patients. Within the AML cohort, we explored the impact of HCK expression on clinical outcomes and its correlation with clinical, genetic, and laboratory characteristics. Furthermore, we evaluated the association between HCK expression and the response to antineoplastic agents using ex vivo assay data from AML patients. HCK expression is higher in differentiated subpopulations of myeloid cells. High HCK expression was observed in patients with chronic myelomonocytic leukemia, chronic myeloid leukemia, and AML. In patients with AML, high levels of HCK negatively impacted overall and disease-free survival. High HCK expression was also associated with worse molecular risk groups and white blood cell count; however, it was not an independent prognostic factor. In functional genomic analyses, high HCK expression was associated with several biological and molecular processes relevant to leukemogenesis. HCK expression was also associated with sensitivity and resistance to several drugs currently used in the clinic. In conclusion, our analysis confirmed the differential expression of HCK in myeloid neoplasms and its potential association with unfavorable molecular risks in AML. We also provide new insights into HCK biological functions, prognosis, and response to antineoplastic agents. (AML prognosis (HCK protooncogene proto oncogene proteintyrosine protein tyrosine family cohort genetic characteristics Furthermore diseasefree disease free survival count however factor analyses leukemogenesis clinic conclusion functions

RESUMO: A crescente demanda por água de coco tem ocasionado a expansão do cultivo de coqueiro-anão-verde irrigado, no entanto, o uso ineficiente da água tem contribuído com a degradação e desperdício dos recursos hídricos, tornando fundamental estudos que visem otimizar o uso da água. Objetivou-se determinar a produtividade física e a produtividade da água do coqueiro-anão-verde, nas condições climáticas de Santa Izabel do Pará, leste da Amazônia, Brasil. O experimento foi realizado no período de 2020 a 2021, em um plantio de coqueiro-anão-verde em espaçamento 7,5 m x 7,5 m em triângulo, na Fazenda Reunidas Sococo, apresentando uma área de aproximadamente 7 ha. A produtividade da água (PA) foi determinada tanto em termos de produção de frutos (PAf) como de produção de água de coco (PAac), através da relação da produtividade de frutos (biomassa do fruto e volume de água) com a evapotranspiração acumulada. O coqueiro-anão apresentou uma produção total de 105 e de 186 frutos planta-1 e de 37 e de 62 L planta-1 de água de coco nos anos de 2020 e 2021. A evapotranspiração total foi de 56,2 m³ (2020) e 53,2 m-3 (2021). A PAf foi de 1,87 frutos m-3 (2020) e 2,94 frutos m-3 (2021) e a PAac de 0,66 L m-3 (2020) e 0,98 L m-3 (2021). RESUMO coqueiroanãoverde coqueiro anão verde irrigado entanto hídricos Objetivouse Objetivou se coqueiroanãoverde, verde, Pará Amazônia Brasil 202 2021 75 5 7, triângulo Sococo ha PA (PA (PAf PAac, , (PAac) biomassa acumulada coqueiroanão 10 18 planta1 planta 1 planta- 3 6 562 56 2 56, (2020 532 53 53, m3 m- . 187 87 1,8 294 94 2,9 (2021 066 0 66 0,6 098 98 0,9 20 (PAac (202 8 1, 29 9 2, 06 0, 09 (20 (2 (

ABSTRACT: The growing demand for coconut water has led to the expansion of irrigated green dwarf coconut cultivation; however, the inefficient use of water has contributed to the degradation and waste of water resources, making fundamental studies aiming to optimize the use of water. The objective of this study was to determine the physical productivity and water productivity of green dwarf coconut palms under the climatic conditions of Santa Izabel do Pará, eastern Amazonia, Brazil. The experiment was carried out from 2020 to 2021, in a green dwarf coconut plantation spaced 7.5 m x 7.5 m in a triangle, at Fazenda Reunidas Sococo, with an area of approximately 7 ha. Water productivity (WP) was determined both in terms of fruit production (WPf) and coconut water production (WPca), through the relationship of fruit productivity (fruit biomass and water volume) with accumulated evapotranspiration. The dwarf coconut tree presented a total production of 105 and 186 fruits plant-1 and 37 and 62 L plant-1 of coconut water in the years 2020 and 2021. The largest volumes of water and the highest weights occurred during the wettest season. WPf was of 1.87 fruits m-3 (2020) and 2.94 fruits m-3 (2021) and WPca 0.66 L m-3 (2020) and 0.98 L m-3 (2021). ABSTRACT cultivation however resources Pará Amazonia Brazil 202 2021 75 5 7. triangle Sococo ha WP (WP (WPf WPca, , (WPca) volume evapotranspiration 10 18 plant1 plant 1 plant- 3 6 season 187 87 1.8 m3 m- (2020 294 2 94 2.9 (2021 066 0 66 0.6 098 98 0.9 . 20 (WPca 8 1. (202 29 9 2. 06 0. 09 (20 (2 (

ABSTRACT Objective: To analyse pharmacological overlap in patients with autism spectrum disorder (ASD) under conscious sedation in a dental office environment, identifying any potential risks and complications. Material and Methods: A critical review was conducted by selecting articles from online databases (Pubmed and Lilacs), using a search algorithm and eligibility criteria. The Medscape® platform was used to verify interactions between drugs commonly used by patients with ASD and medications used for sedation in paediatric dentistry. Results: Due to their polydrug use, children with ASD are at risk of complications, namely Serotonin Syndrome (SS), Neuroleptic Malignant Syndrome (NMS), increase or decrease of the QT interval (QTi) and Torsade de Pointes (TdP), due to pre-existence of metabolic syndrome, deepening the sedation level or even leading to a decrease in the sedative capacity of the drugs used. Conclusion: It is essential to assess better drug interaction in ASD patients submitted to sedation. The severity of the disorder and the need for sedation for dental treatment are directly proportional. However, increases in sedative doses tend to increase risks and complications in children with ASD. Objective (ASD environment Methods Pubmed Lilacs, Lilacs , Lilacs) criteria Medscape dentistry Results use SS, SS (SS) NMS, NMS (NMS) QTi (QTi TdP, TdP (TdP) preexistence pre existence syndrome Conclusion proportional However (SS (NMS (TdP

Abstract There is growing interest in using cannabinoids across various clinical scenarios, including pain medicine, leading to the disregard of regulatory protocols in some countries. Legislation has been implemented in Brazil, specifically in the state of São Paulo, permitting the distribution of cannabinoid products by health authorities for clinical purposes, free of charge for patients, upon professional prescription. Thus, it is imperative to assess the existing evidence regarding the efficacy and safety of these products in pain management. In light of this, the São Paulo State Society of Anesthesiology (SAESP) established a task force to conduct a narrative review on the topic using the Delphi method, requiring a minimum agreement of 60% among panelists. The study concluded that cannabinoid products could potentially serve as adjuncts in pain management but stressed the importance of judicious prescription. Nevertheless, this review advises against their use for acute pain and cancer-related pain. In other clinical scenarios, established treatments should take precedence, particularly when clinical protocols are available, such as in neuropathic pain. Only patients exhibiting poor therapeutic responses to established protocols or demonstrating intolerance to recommended management may be considered as potential candidates for cannabinoids, which should be prescribed by physicians experienced in handling these substances. Special attention should be given to individual patient characteristics and the likelihood of drug interactions. scenarios medicine countries Brazil purposes prescription Thus SAESP (SAESP method 60 panelists Nevertheless cancerrelated cancer related precedence available substances interactions 6

Abstract Objective: Cancer genomics and transcriptomics studies have provided a large volume of data that enables to test of hypotheses based on real data from cancer patients. Ezrin (encoded by the EZR gene) is a highly expressed protein in cancer that contributes to linking the actin cytoskeleton to the cell membrane and signal transduction pathways involved in oncogenesis and disease progression. NSC305787 is a pharmacological ezrin inhibitor with potential antineoplastic effects. In the present study, the authors prospected EZR mRNA levels in a pan-cancer analysis and identified potential cancers that could benefit from anti-EZR therapies. Methods: This study analyzed TCGA data for 32 cancer types, emphasizing cervical squamous cell carcinoma and stomach adenocarcinoma. It investigated the impact of EZR transcript levels on clinical outcomes and identified differentially expressed genes. Cell lines were treated with NSC305787, and its effects were assessed through various cellular and molecular assays. Results: EZR mRNA levels are highly expressed, and their expression is associated with biologically relevant molecular processes in cervical squamous carcinoma and stomach adenocarcinoma. In cellular models of cervical and gastric cancer, NSC305787 reduces cell viability and clonal growth (p < 0.05). Molecular analyses indicate that the pharmacological inhibition of EZR induces molecular markers of cell death and DNA damage, in addition, to promoting the expression of genes associated with apoptosis and inhibiting the expression of genes related to survival and proliferation. Conclusion: The present findings provide promising evidence that ezrin may be a molecular target in the treatment of cervical and gastric carcinoma. Objective patients encoded gene progression NSC NSC30578 pancancer pan antiEZR anti therapies Methods 3 types adenocarcinoma assays Results p 0.05. 005 0.05 . 0 05 0.05) damage addition proliferation Conclusion NSC3057 00 0.0 NSC305 0. NSC30 NSC3

ABSTRACT BACKGROUND: Acute kidney failure is a serious consequence of coronavirus disease 2019 (COVID-19). OBJECTIVES: To identify the prevalence of COVID-19, kidney failure, frequency of death, and associated factors in patients receiving intensive care. DESIGN AND SETTING: Analytical cross-sectional study conducted in the intensive care unit (ICU) of a medium-sized philanthropic general hospital in center-west Minas Gerais. METHODS: Adults and older individuals who underwent real-time polymerase chain reaction testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were evaluated by the nephrology team. RESULTS: Among the 176 patients, the prevalence of COVID-19 and acute kidney injury (AKI) were 103 (58.5%) and 132 (75%), respectively, and 44 (25%) had chronic kidney disease (CKD) and 16 (15,5%) were positive for SARS-CoV-2. In the Charlson index classification, which estimates the risk of death, a statistically significant difference was identified in the percentages of groups with and without COVID-19 for indices 0, 1, and 2. There was a significant association between kidney disease and ICU mortality (P < 0.05). Patients with CKD had fewer fatal outcomes (13/97, 13.4%) than those with AKI (85/97, 87.6%). CONCLUSIONS: COVID-19 rates remained high long after diagnosis and prevention of SARS-CoV-2 infection. In addition, a higher death rate among patients who developed AKI, whose prevalence was also greater than that in the national literature, regardless of the presence of COVID-19, revealed a worrying scenario and corroborated the need for early and judicious approaches to preserve the lives of patients with AKI admitted to intensive care units. BACKGROUND 201 COVID19. COVID19 COVID 19 . (COVID-19) OBJECTIVES COVID19, 19, SETTING crosssectional cross sectional (ICU mediumsized medium sized centerwest center west Gerais METHODS realtime real time SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 team RESULTS 17 COVID-1 (AKI 10 58.5% 585 58 5 (58.5% 13 75%, 75 75% , (75%) respectively 4 25% 25 (25% (CKD 1 15,5% 155 15 (15,5% SARSCoV2. classification 0 P 0.05. 005 0.05 05 0.05) 13/97, 1397 97 (13/97 13.4% 134 85/97, 8597 85 (85/97 87.6%. 876 87.6% 87 6 87.6%) CONCLUSIONS SARS-CoV- infection addition literature units 20 COVID1 (COVID-19 (SARS-CoV- COVID- 58.5 (58.5 7 (75% (25 15,5 (15,5 00 0.0 13/97 139 9 (13/9 13.4 85/97 859 8 (85/9 87.6 SARS-CoV (COVID-1 (SARS-CoV 58. (58. (75 (2 15, (15, 0. 13/9 (13/ 13. 85/9 (85/ 87. (COVID- (58 (7 ( (15 13/ (13 85/ (85 (COVID (5 (1 (8