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Resumo Fundamento: A Cardiomiopatia Chagásica Crônica (CCC) é causada por um processo inflamatório induzido pelo Trypanosoma cruzi, que leva à miocardite com fibrose reativa e reparativa. A CCC progride com alterações de perfusão miocárdica e eventos histopatológicos que afetam a Aptidão Cardiorrespiratória (ACR). Objetivos: Avaliamos os efeitos do Treinamento Físico Aeróbico (TFA) na perfusão miocárdica e nos comprometimentos morfológicos e funcionais relacionados à inflamação e fibrose em hamsters sírios com CCC. Como objetivo secundário, analisamos as áreas de secção transversa do músculo esquelético. Métodos: Hamsters com CCC e seus respectivos controles foram divididos em quatro grupos: CCC sedentário, CCC-TFA, controle sedentário e controle TFA. Sete meses após a infecção, os animais foram submetidos à ecocardiografia, à cintilografia de perfusão miocárdica e ao teste de esforço cardiopulmonar. TFA de intensidade moderada foi realizado durante cinquenta minutos, cinco vezes por semana, por oito semanas. Posteriormente, os animais foram reavaliados. A análise histopatológica foi realizada após os procedimentos acima mencionados. O nível de significância foi estabelecido em 5% em todas as análises (p<0,05). Resultados: Animais com CCC sedentários apresentaram piores Defeitos de Perfusão Miocárdica (DPM) ao longo do tempo, Fração de Ejeção do Ventrículo Esquerdo (FEVE) reduzida, e apresentaram mais inflamação e fibrose quando comparados aos demais grupos (análise ANOVA mista). Por outro lado, o TFA foi capaz de mitigar a progressão do DPM, atenuar a inflamação e a fibrose e melhorar a eficiência da ACR em animais CCC-TFA. Conclusão: Nosso estudo demonstrou que o TFA melhorou a disfunção cardíaca, DPM e reduziu a inflamação e a fibrose em modelos de hamster com CCC. Além disso, os animais CCC-SED apresentaram atrofia do músculo esquelético, enquanto os animais CCC-TFA apresentaram a AST do músculo esquelético preservada. Compreender os efeitos da TFA nas dimensões fisiopatológicas da CCC é crucial para futuras pesquisas e intervenções terapêuticas. Fundamento (CCC cruzi reparativa ACR. . (ACR) Objetivos (TFA secundário Métodos CCCTFA, CCCTFA TFA, infecção ecocardiografia cardiopulmonar minutos semana semanas Posteriormente reavaliados mencionados 5 p<0,05. p005 p p<0,05 0 05 (p<0,05) Resultados (DPM tempo FEVE (FEVE reduzida mista. mista mista) lado CCCTFA. Conclusão cardíaca disso CCCSED SED preservada terapêuticas (ACR p00 p<0,0 (p<0,05 p0 p<0, (p<0,0 p<0 (p<0, p< (p<0 (p< (p

Abstract Background: Chronic Chagas cardiomyopathy (CCC) is caused by an inflammatory process induced by Trypanosoma cruzi, which leads to myocarditis with reactive and reparative fibrosis. CCC progresses with myocardial perfusion abnormalities and histopathological events that affect cardiorespiratory fitness (CRF). Objectives: We evaluated the effects of aerobic physical training (APT) on myocardial perfusion and on morphological and functional impairments related with inflammation and fibrosis in Syrian hamsters with CCC. As a secondary objective, we analyzed the cross-sectional areas of the skeletal muscle. Methods: Hamsters with CCC and their respective controls were divided into four groups: CCC sedentary, CCC-APT, sedentary control and APT control. Seven months after infection, the animals underwent echocardiography, myocardial perfusion scintigraphy and cardiopulmonary exercise testing. Moderate-intensity APT was performed for fifty minutes, five times a week, for eight weeks. Subsequently, the animals were reassessed. Histopathological analysis was conducted after the above-mentioned procedures. The level of significance was set at 5% in all analyses (p<0.05). Results: CCC sedentary animals presented worse myocardial perfusion defects (MPD) over time, reduced left ventricle ejection fraction (LVEF) and showed more inflammation and fibrosis when compared to other groups (mixed ANOVA analysis). Conversely, APT was able to mitigate the progression of MPD, ameliorate inflammation and fibrosis and improve CRF efficiency in CCC-APT animals. Conclusions: Our study demonstrated that APT ameliorated cardiac dysfunction, MPD, and reduced inflammation and fibrosis in CCC hamster models. Additionally, CCC-SED animals presented skeletal muscle atrophy while CCC-APT animals showed preserved skeletal muscle CSA. Understanding APT's effects on CCC's pathophysiological dimensions is crucial for future research and therapeutic interventions. Background (CCC cruzi CRF. . (CRF) Objectives (APT objective crosssectional cross sectional Methods CCCAPT, CCCAPT APT, infection echocardiography testing Moderateintensity Moderate intensity minutes week weeks Subsequently reassessed abovementioned above mentioned procedures 5 p<0.05. p005 p p<0.05 0 05 (p<0.05) Results MPD (MPD time LVEF (LVEF mixed analysis. analysis) Conversely Conclusions dysfunction models Additionally CCCSED SED CSA APTs s CCCs interventions (CRF p00 p<0.0 (p<0.05 p0 p<0. (p<0.0 p<0 (p<0. p< (p<0 (p< (p

https://doi.org/10.36660/abc.20230707

Immunization against covid-19 and mortality in hospitalized patients: a retrospective cohort
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Figueiredo, Alexandre Medeiros de

; Massuda, Adriano

; Fernandez, Michelle

; Medeiros Neto, Agostinho Hermes de

; Carvalho, Marcus

Revista de Saúde Pública

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2024, Volume 58 elocation 07

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

https://doi.org/10.11606/s1518-8787.2024058005476

Design, Synthesis, and Molecular Docking Studies of New Quinoline-Thiazole Hybrids, Potential Leads in the Development of Novel Antileukemic Agents Design Synthesis QuinolineThiazole Quinoline Thiazole Hybrids
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Facchinetti, Victor

; Gomes, Claudia Regina B.

; Aboud, Karoline C. L.

; Fiorot, Rodolfo G.

; Carvalho, Guilherme G. C. de

; Paier, Carlos Roberto K.

; Pessoa, Claudia do Ó

; Gomes, Anne Caroline C.

; Souza, Marcus Vinícius N. de

; Vasconcelos, Thatyana R. A.

Journal of the Brazilian Chemical Society

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2024, Volume 35 N. 2 elocation e-20230139

Abstract: En | Text: En | PDF: En

This work describes the multigram-scale synthesis of the building-block N1 (7 chloroquinolin-4-yl)ethane-1,2-diamine via sonochemistry and its use in the synthesis of seven new quinoline-thiazole hybrids endowed with interesting anticancer activity. Target compounds were planned based on the drugs chloroquine and primaquine and the desired thiazoles were obtained through the Hantzsch thiazole synthesis, without the use of catalysts, by reacting key intermediate 1-(2-((7-chloroquinolin-4-yl)amino)ethyl)thiourea, obtained in two-steps from N1 (7-chloroquinolin-4-yl)ethane-1,2-diamine, with different 2-bromoacetophenones. The novel molecules were assessed against four different leukemia cell lines (HL60, K562, KASUMI-1, and KG-1) plus normal fibroblasts (L929), using the 3-(4,5-dimethyl-2-thiazol)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and showed, overall, a high cytotoxic profile, but with interesting selectivity index, especially against K562 cells (1.89 to 5.50), when compared to standard doxorubicin (3.51). Docking studies suggest that all tested derivatives are able to interact with BCR-ABL1 tyrosine kinase enzyme, and, therefore, these molecules may be promising leads against chronic myeloid leukemia. multigramscale multigram scale buildingblock building block N 7 ( chloroquinolin4ylethane1,2diamine chloroquinolin4ylethane12diamine chloroquinolinylethanediamine chloroquinolin 4 yl ethane 1,2 diamine 1 2 quinolinethiazole quinoline activity catalysts 127chloroquinolin4ylaminoethylthiourea, 127chloroquinolin4ylaminoethylthiourea chloroquinolinylaminoethylthiourea amino ethyl thiourea, thiourea 1-(2-((7-chloroquinolin-4-yl)amino)ethyl)thiourea twosteps two steps 7chloroquinolin4ylethane1,2diamine, 7chloroquinolin4ylethane12diamine diamine, (7-chloroquinolin-4-yl)ethane-1,2-diamine 2bromoacetophenones. 2bromoacetophenones bromoacetophenones bromoacetophenones. 2-bromoacetophenones HL60, HL60 HL (HL60 K KASUMI1, KASUMI1 KASUMI 1, KASUMI-1 KG1 KG KG-1 L929, L929 L , (L929) 34,5dimethyl2thiazol2,5diphenyl2Htetrazolium 345dimethyl2thiazol25diphenyl2Htetrazolium dimethylthiazoldiphenylHtetrazolium 3 4,5 dimethyl thiazol 2,5 diphenyl 2H tetrazolium 5 H MTT (MTT assay showed overall profile index K56 1.89 189 89 (1.8 5.50, 550 5.50 50 5.50) 3.51. 351 3.51 . 51 (3.51) BCRABL1 BCRABL BCR ABL1 ABL BCR-ABL enzyme therefore chloroquinolin4ylethane1 2diamine ylethane 12 ylaminoethylthiourea 7chloroquinolin4ylethane1 7chloroquinolin4ylethane1,2diamine HL6 (HL6 KASUMI- KG- L92 (L929 34 5dimethyl2thiazol2 5diphenyl2Htetrazolium Htetrazolium 45 4, 25 2, K5 1.8 18 8 (1. 55 5.5 35 3.5 (3.51 chloroquinolinylethane chloroquinolin4ylethane 7chloroquinolin4ylethane (HL L9 (L92 dimethylthiazol 5dimethyl2thiazol diphenylHtetrazolium 1. (1 5. 3. (3.5 (L9 (3. (L (3

https://doi.org/10.21577/0103-5053.20230139

Students’ perception of the impact of a Geotechnical Engineering field activity on their competences development Students
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França, Fagner Alexandre Nunes de

; Lyra, Marcus Vinicius Melo de

; Carvalho, Matheus Gomes de

; Opolski, Wagner José

Soils and Rocks

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2024, Volume 47 N. 2 elocation e2024006423

Abstract: En | Text: En | PDF: En

Abstract The need to develop several students’ competencies is one of the leading challenges for Engineering instructors in undergraduate courses. It has been quite exhausting in many cases, mainly due to the lack of professors’ expertise in engineering education. Case studies may provide examples and help develop professors’ ability to design effective learning experiences. In this context, this paper presents a case study of implementing an in-class/ex-class activity conducted in the Soil Mechanics-I course at the Federal University of Rio Grande do Norte. Additionally, it aims to discuss students’ perception regarding development of the proposed activity and competences. The activity comprised three phases: selection of Geotechnical Engineering problems on university campus, documentation and analysis of each situation, and presentation of solutions considering technical, environmental, and social aspects. Students' perceptions were assessed using an anonymous online survey (18 Likert and open-ended questions), divided into three categories: general impressions, competencies development, and open statements. General impressions and competencies development were mostly positive, with deadlines reported as the most challenging aspect. Open questions responses provided positive feedback, emphasizing the main developed competencies, according to students’ perspective (e.g. leadership, interpersonal relationship, and analytical view of the problem). The need of dealing with real problems and work in groups appears to be a successful approach for teaching Geotechnical Engineering courses and developing competences in Engineering undergraduate courses. This case study can support innovation in teaching any engineering course and help students face future professional challenges. cases professors education experiences context inclass/exclass inclassexclass class/ex class ex MechanicsI Mechanics I Norte Additionally phases campus situation technical environmental aspects Students 18 (1 openended ended questions, , questions) categories statements aspect feedback e.g. eg e g (e.g leadership relationship problem. problem . problem) inclass exclass classex 1 ( e.g

https://doi.org/10.28927/sr.2024.006423

Immunization against covid-19 and mortality in hospitalized patients: a retrospective cohort covid19 covid 19 covid-1 patients covid1 1 covid-
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Figueiredo, Alexandre Medeiros de

; Massuda, Adriano

; Fernandez, Michelle

; Medeiros Neto, Agostinho Hermes de

; Carvalho, Marcus

Revista de Saúde Pública

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2024, Volume 58 elocation 07

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO Avaliar a efetividade das vacinas desenvolvidas contra a covid-19 na redução da mortalidade em pessoas internadas com síndrome respiratória aguda grave (SRAG) causada pelo SARS-CoV-2. MÉTODOS Trata-se de uma coorte retrospectiva que avaliou fatores de riscos e a efetividade do esquema vacinal com duas doses na redução da mortalidade de pessoas internadas por covid-19 no estado da Paraíba entre fevereiro e novembro de 2021. As variáveis explicativas foram situação vacinal, presença de comorbidades, características socioeconômicas e demográficas. Foram realizadas análises descritivas e regressão logística bivariada e multivariável. RESULTADOS A maior parte das internações e óbitos ocorreram até maio de 2021. O percentual de pacientes com esquema vacinal completo foi similar entre pacientes internados em hospitais públicos e privados e superior em residentes de municípios com menor desenvolvimento. A análise multivariável demonstrou que mulheres (OR = 0,896; IC95% 0,830–0,967) e pessoas internadas em hospitais privados (OR = 0,756; IC95% 0,679–0,842) apresentaram menor chance de morte. A presença de alguma comorbidade (OR = 1,627; IC95% 1,500–1,765) e idade ≥ 80 anos (OR = 7,426; IC95% 6,309–8,741) foram fatores de risco de óbito. Pacientes com esquema vacinal completo no momento da internação apresentaram uma chance 41,7% menor de morte (OR = 0,583; IC95% 0,501–0,679) por covid-19 na análise ajustada, quando comparados com pacientes não vacinados. CONCLUSÕES O estudo revela que a imunização foi efetiva na redução da chance de óbito por covid-19. Os resultados sugerem que uma maior cobertura vacinal no primeiro semestre de 2021 evitaria milhares de mortes no país. covid19 covid 19 covid-1 SRAG (SRAG SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. 2 SARS-CoV-2 Tratase Trata se comorbidades demográficas desenvolvimento OR 0,896 0896 0 896 IC95 IC 0,830–0,967 08300967 830 967 0,756 0756 756 0,679–0,842 06790842 679 842 1,627 1627 1 627 1,500–1,765 15001765 500 765 8 7,426 7426 7 426 6,309–8,741 63098741 6 309 741 417 41 41,7 0,583 0583 583 0,501–0,679 05010679 501 ajustada vacinados covid19. 19. 202 país covid1 covid- SARS-CoV- 0,89 089 89 IC9 0,830–0,96 0830096 83 96 0,75 075 75 0,679–0,84 0679084 67 84 1,62 162 62 1,500–1,76 1500176 50 76 7,42 742 42 6,309–8,74 6309874 30 74 4 41, 0,58 058 58 0,501–0,67 0501067 20 SARS-CoV 0,8 08 0,830–0,9 083009 9 0,7 07 0,679–0,8 067908 1,6 16 1,500–1,7 150017 5 7,4 6,309–8,7 630987 3 0,5 05 0,501–0,6 050106 0, 0,830–0, 08300 0,679–0, 06790 1, 1,500–1, 15001 7, 6,309–8, 63098 0,501–0, 05010 0,830–0 0830 0,679–0 0679 1,500–1 1500 6,309–8 6309 0,501–0 0501 0,830– 083 0,679– 067 1,500– 150 6,309– 630 0,501– 050 0,830 0,679 06 1,500 15 6,309 63 0,501 0,83 0,67 1,50 6,30 0,50 0,6 1,5 6,3 6,

ABSTRACT OBJECTIVE To evaluate the effectiveness of vaccines developed against covid-19 in reducing mortality in people hospitalized with severe acute respiratory syndrome (SARS) caused by SARS-CoV-2. METHODS This is a retrospective cohort that evaluated risk factors and the effectiveness of the two-dose vaccination schedule in reducing the mortality of people hospitalized for covid-19 in the state of Paraíba from February to November 2021. The explanatory variables were vaccination status, presence of comorbidities, socioeconomic and demographic characteristics. Descriptive analyses and bivariate and multivariable logistic regression were performed. RESULTS Most hospitalizations and deaths occurred until May 2021. The percentage of patients with a complete vaccination schedule was similar across patients admitted to public and private hospitals and higher in residents of less developed municipalities. Multivariable analysis demonstrated that women (OR = 0.896; 95%CI 0.830–0.967) and people admitted to private hospitals (OR = 0.756; 95%CI 0.679–0.842) were less likely to die. Presence of any comorbidity (OR = 1.627; 95%CI 1.500–1.765) and age ≥ 80 years (OR = 7.426; 95%CI 6.309–8.741) were risk factors for death. Patients with complete vaccination schedule at the time of admission were 41.7% less likely to die (OR = 0.583; 95% CI 0.501–0.679) from covid-19 in the adjusted analysis, as compared to unvaccinated patients. CONCLUSIONS The study reveals that immunization was effective in reducing the likelihood of death from covid-19. The results suggest that greater vaccination coverage in the first half of 2021 would prevent thousands of deaths in the country. covid19 covid 19 covid-1 SARS (SARS SARSCoV2. SARSCoV2 SARSCoV CoV 2. 2 SARS-CoV-2 twodose two dose status comorbidities characteristics performed municipalities OR 0.896 0896 0 896 95CI 95 0.830–0.967 08300967 830 967 0.756 0756 756 0.679–0.842 06790842 679 842 1.627 1627 1 627 1.500–1.765 15001765 500 765 8 7.426 7426 7 426 6.309–8.741 63098741 6 309 741 417 41 41.7 0.583 0583 583 0.501–0.679 05010679 501 covid19. 19. 202 country covid1 covid- SARS-CoV- 0.89 089 89 9 0.830–0.96 0830096 83 96 0.75 075 75 0.679–0.84 0679084 67 84 1.62 162 62 1.500–1.76 1500176 50 76 7.42 742 42 6.309–8.74 6309874 30 74 4 41. 0.58 058 58 0.501–0.67 0501067 20 SARS-CoV 0.8 08 0.830–0.9 083009 0.7 07 0.679–0.8 067908 1.6 16 1.500–1.7 150017 5 7.4 6.309–8.7 630987 3 0.5 05 0.501–0.6 050106 0. 0.830–0. 08300 0.679–0. 06790 1. 1.500–1. 15001 7. 6.309–8. 63098 0.501–0. 05010 0.830–0 0830 0.679–0 0679 1.500–1 1500 6.309–8 6309 0.501–0 0501 0.830– 083 0.679– 067 1.500– 150 6.309– 630 0.501– 050 0.830 0.679 06 1.500 15 6.309 63 0.501 0.83 0.67 1.50 6.30 0.50 0.6 1.5 6.3 6.

https://doi.org/10.11606/s1518-8787.2024058005476

From "dose erythema" to FLASH radiotherapy: impacts on clinical practice dose erythema radiotherapy
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Carvalho, Heloisa de Andrade

; Mauro, Geovanne Pedro

; Castilho, Marcus Simões

Revista da Associação Médica Brasileira

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2024, Volume 70 Suppl. 1 elocation e2024S130

Abstract: En | Text: En | PDF: En

https://doi.org/10.1590/1806-9282.2024s130

A importância do pré e pós-natal odontológico para o incentivo e apoio ao aleitamento materno
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Baum, Luciana Reis

; Schaidhauer, Flavia Gheller

; Brockveld, Lucimeire

; Carvalho, Marcus Renato de

; Ercolin, Ludmila Tavares Costa

Physis: Revista de Saúde Coletiva

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2024, Volume 34 elocation e34089

Abstract: En Pt | Text: En Pt | PDF: En | PDF: Pt

Abstract Breastfeeding (BF) is rarely covered in technical and undergraduate Dentistry courses. This review aimed to research dental issues regarding breastfeeding to promote BF from pre- to post-natal dental care. The method adopted was the PICO strategy with the descriptors: “breastfeeding” and “dentistry”, and the search was carried out over the last 10 years until October 2023 in five databases and included studies. Of 209 articles, 101 were selected under inclusion and exclusion criteria according to the type of study and subject covered. The results show the promotion of public policies in BF; its importance and benefits for oral and general health; food; breathing; sleep disorders; pre- and post-natal dental care; use of medications and drugs during breastfeeding; maternal counseling; adequate breastfeeding management and technique; multidisciplinary work; professional training; sociodemographic factors, risk of caries and malocclusion; craniofacial development; oral functions; oral microbiota; special cases: ankyloglossia; cleft palate; neonatal teeth, hypo-mineralization, autism, vertical transmission; harmful habits and non-nutritive sucking. We conclude that there is evidence from a dental perspective to guide mothers and families about BF. This content should be part of training courses in the health area.

Resumo O tema do Aleitamento Materno (AM) é pouco abordado nos cursos técnicos e de graduação em Odontologia. O objetivo desta revisão foi pesquisar conteúdos odontológicos relacionados à amamentação para promoção do AM desde o pré ao pós-natal. O método adotado foi a estratégia PICO, com os descritores: “amamentação” e “odontologia”. A busca foi realizada dos últimos 10 anos até outubro de 2023 em cinco bases de dados e outros estudos incluídos. Dos 209 artigos, 101 foram selecionados sob critérios de inclusão e exclusão de acordo com o tipo de estudo e conteúdo abordado. Os resultados obtidos foram: promoção de políticas públicas em AM; sua importância e benefícios para a saúde oral e geral; alimentação; respiração; distúrbios do sono; atendimento odontológico pré e pós-natal; uso de medicamentos e drogas durante a amamentação; aconselhamento materno; manejo e técnica adequada de amamentação; trabalho multidisciplinar; treinamento profissional; fatores sociodemográficos, risco de cárie e má oclusão; desenvolvimento craniofacial; funções orais; microbiota oral; casos especiais: anquiloglossia; fenda palatina; dentes neonatais, hipomineralização, autismo, transmissão vertical; hábitos prejudiciais e sucção não nutritiva. Conclui-se que existem evidências na perspectiva odontológica para orientar mães e familiares sobre o Aleitamento Materno. Esse conteúdo deverá fazer parte de cursos de formação na área da saúde.

https://doi.org/10.1590/s0103-7331202434089pt

Use of transient elastography for hepatic steatosis and fibrosis evaluation in patients with subclinical hypothyroidism
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Santos, Milena Tauil Auad Noronha

; Villela-Nogueira, Cristiane Alves

; Leite, Nathalie Carvalho

; Teixeira, Patrícia de Fátima dos Santos

; de Souza, Marcus Vinicius Leitão

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e230477

Abstract: En | Text: En | PDF: En

ABSTRACT Objective: To evaluate the association between subclinical hypothyroidism and hepatic steatosis and fibrosis using the noninvasive diagnostic methods transient hepatic elastography (TE) and controlled attenuation parameter (CAP) in patients with subclinical hypothyroidism. Subjects and methods: This was a cross-sectional study including women with confirmed spontaneous subclinical hypothyroidism and an age- and body mass index (BMI)-matched control group without thyroid disease or circulating antithyroperoxidase (anti-TPO) antibodies. Exclusion criteria were age > 65 years, thyroid-stimulating hormone (TSH) > 10.0 mIUI/L, BMI ≥ 35 kg/m2, diabetes, or other chronic liver diseases. Liver stiffness was classified according to TE values (in kPa) and ranged from absence of fibrosis (F0) to advanced fibrosis (F3). Hepatic steatosis was classified according to CAP values (in dB/m) and ranged from low-grade (S1) to advanced (S3) steatosis. Results: Of 68 women enrolled, 27 were included in the subclinical hypothyroidism group and 41 in the control group. Advanced steatosis (S3) was more frequent in the subclinical hypothyroidism group (25.9% versus 7.3%, respectively, p = 0.034). Circulating anti-TPO was an independent factor associated with advanced steatosis (odds ratio 9.5, 95% confidence interval 1.3–68.3). In multiple linear regression analysis, TE values (which evaluated fibrosis) correlated negatively with free thyroxine levels. Conclusion: The results of this study strengthen the hypothesis that hepatic steatosis is associated with autoimmune (positive anti-TPO) subclinical hypothyroidism, independently from BMI. However, subclinical hypothyroidism alone does not appear to be associated with a significantly increased risk of hepatic fibrosis. Objective (TE (CAP crosssectional cross sectional BMImatched matched antiTPO anti TPO (anti-TPO antibodies 6 years thyroidstimulating stimulating TSH (TSH 100 10 0 10. mIUIL mIUI L mIUI/L 3 kgm2 kgm kg m2 m kg/m2 diabetes diseases kPa F0 F (F0 F3. F3 . (F3) dB/m dBm dB lowgrade low grade S1 S (S1 S3 (S3 Results enrolled 2 4 25.9% 259 25 9 (25.9 73 7 7.3% respectively 0.034. 0034 0.034 034 0.034) odds 95 5 9.5 1.3–68.3. 13683 1.3–68.3 1 1.3–68.3) analysis which levels Conclusion positive However kg/m (F (F3 (S 25.9 (25. 7.3 003 0.03 03 9. 1368 1.3–68. 25. (25 7. 00 0.0 136 1.3–68 (2 0. 13 1.3–6 ( 1.3– 1.3 1.

https://doi.org/10.20945/2359-4292-2023-0477

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 N. 7 elocation s00441788586

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

10.

Contextual inequalities in specialized dental public health care in Brazil
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PIRES, Ana Luiza Cardoso

; COSTA, Francine dos Santos

; D’ÁVILA, Otávio Pereira

; CARVALHO, Rodrigo Varella de

; CONDE, Marcus Cristian Muniz

; CORREA, Marcos Britto

; DEMARCO, Flávio Fernando

; CHISINI, Luiz Alexandre

Brazilian Oral Research

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2024, Volume 38 elocation e023

Abstract: En | Text: En | PDF: En

Abstract The present study aimed to investigate the contextual inequalities of specialized public dental care (SPDC) in Brazil. The outcome was the trajectory of dental specialized production in municipalities with SPDC (from 2015 to 2017) obtained by group-based trajectory modeling. A Poisson regression model was used to analyze the factors associated with the high trajectory of SPDC production. The inequality indicators for SPDC production were the slope index and the concentration index according to contextual factors. The study included 954 SPDC units distributed across 893 municipalities. Among the municipalities evaluated, 62.9% had a low trajectory of SPDC. Large-sized municipalities had the highest production (IRR = 2.84, 95%CI: 1.94–4.14) and the southern region had the lowest production (IRR = 0.73, 95%CI: 0.58–0.92). Municipalities presenting a very high human development index (HDI) showed the greatest SPDC production (IRR = 3.34, 95%CI: 1.09–10.24), as well as municipalities with the highest tertile of schooling rate (IRR = 1.23, 95%CI: 1.00–1.50). The absolute inequality was 52.1 percentage points for the average monthly wage (p < 0.001), 61.0 percentage points for the HDI (p < 0.001), -22.1 for infant mortality rate (p <0.001), and 14.8 for the schooling rate (p = 0.012). Thus, there are contextual inequalities in the Brazilian SPDC. Higher scores for social indicators were associated with better SPDC performance. (SPDC Brazil from 201 2017 groupbased group based modeling 95 89 evaluated 629 62 9 62.9 Largesized Large sized IRR 284 2 84 2.84 95%CI 95CI CI 1.94–4.14 194414 1 94 4 14 073 0 73 0.73 0.58–0.92. 058092 0.58–0.92 . 58 92 0.58–0.92) (HDI 334 3 34 3.34 1.09–10.24, 1091024 1.09–10.24 , 09 10 24 1.09–10.24) 123 23 1.23 1.00–1.50. 100150 1.00–1.50 00 50 1.00–1.50) 521 52 52. p 0.001, 0001 0.001 001 0.001) 610 61 61. 22.1 221 22 -22. <0.001, <0.001 <0.001) 148 8 14. 0.012. 0012 0.012 012 0.012) Thus performance 20 6 62. 28 2.8 1.94–4.1 19441 07 7 0.7 05809 0.58–0.9 5 33 3.3 109102 1.09–10.2 12 1.2 10015 1.00–1.5 000 0.00 22. -22 <0.00 0.01 01 2. 1.94–4. 1944 0. 0580 0.58–0. 3. 10910 1.09–10. 1. 1001 1.00–1. 0.0 -2 <0.0 1.94–4 194 058 0.58–0 1091 1.09–10 100 1.00–1 - <0. 1.94– 19 05 0.58– 109 1.09–1 1.00– <0 1.94 0.58 1.09– 1.00 1.9 0.5 1.09 1.0

https://doi.org/10.1590/1807-3107bor-2024.vol38.0023

11.

Human venous blood derivatives as fetal bovine serum substitute for fibroblast culture cells in a fibrin construct
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Chisini, Luiz Alexandre

; Conde, Marcus Cristian Muniz

; Karam, Sarah Arangurem

; Carvalho, Rodrigo Varella de

; Tarquinio, Sandra Beatriz Chaves

; Demarco, Flávio Fernando

Brazilian Journal of Oral Sciences

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2024, Volume 23 elocation e240327

Abstract: En | Text: En | PDF: En

Aim Venous blood derivatives (VBDs) have been suggested as substitutes for Fetal Bovine Serum (FBS) to improve the clinical transition of cell-based therapies. The literature is not clear about which is the best VBDs substitute. The present study aimed to evaluate the influence of VBDs on cell viability and describe a new method to seed these cells in a 3D Platelet-Rich Fibrin (PRF). Methods Blood was processed to obtain Platelet-Poor Plasma from PRF (P-PRF), Human Serum (HS), Platelet-Poor Plasma from PRP (P-PRP), activated-PRP (a-PRP), and Platelet lysate (PL). Cells were supplemented with each VBD at 10% and FBS at 10% was the control. Cell viability (fibroblast 3T3/NIH) test was evaluated with MTT assay in two ways: i) cell-seeded and expanded with VBD; ii) cell-seed with FBS and expanded with VBD. To seed the Fibrin construct, cells were suspended in PBS and dropped into the blood sample before performing Choukroun’s protocol for PRF. Constructs were cultured for 7 days in VBD supplements and FBS. Histological and Immunohistochemical analysis with vimentin was performed. Cell viability was analyzed by one-way ANOVA. Results VBD’s production time was very heterogeneous. Cells expanded in HS and a-PRP has grown faster. VBD-supplemented culture media provided cell culture highly sensible to trypsin/EDTA 0.25%. Cells seeded and expanded with VBD presented viability comparable to FBS in HS, a-PRP, and P-PRP (p>0.05) and lower in P-PRF and PL groups (p<0.05). The viability of cell seed with FBS and expanded with VBD was similar between P-PRF, a-PRP, PL, and FBS (p>0.05) and lower in HS and P-PRP (p<0.005). PRF-seeded cells showed a positive expression of vimentin and were able to maintain all cells supplemented with VBD. Conclusion VBD supplements were able to maintain fibroblast cells in 2D and 3D cultures. The new method of the fibrin-cell construct was efficient to insert the cells into the fibrin network. (VBDs (FBS cellbased based therapies substitute D PlateletRich Rich . (PRF) PlateletPoor Poor PPRF, PPRF P , (P-PRF) (HS) PPRP, PPRP (P-PRP) activatedPRP activated aPRP, aPRP (a-PRP) PL. (PL) 10 control 3T3/NIH 3T3NIH TNIH 3T3 NIH T ways i cellseeded ii cellseed Choukrouns Choukroun s performed oneway one way ANOVA heterogeneous faster VBDsupplemented trypsinEDTA trypsin EDTA 025 0 25 0.25% PRP, p>0.05 p005 p 05 (p>0.05 p<0.05. p<0.05 (p<0.05) PRF, p<0.005. p0005 p<0.005 005 (p<0.005) PRFseeded cultures fibrincell network (PRF (P-PRF (HS (P-PRP (a-PRP (PL 1 3T 02 2 0.25 p>0.0 p00 (p>0.0 p<0.0 (p<0.05 p000 p<0.00 00 (p<0.005 0.2 p>0. p0 (p>0. p<0. (p<0.0 (p<0.00 0. p>0 (p>0 p<0 (p<0. p> (p> p< (p<0 (p (p<

https://doi.org/10.20396/bjos.v23i00.8670327

12.

Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.

; Valim, Michel P.

; Zaher, Hussam

; Rafael, José A.

; Forzza, Rafaela C.

; Percequillo, Alexandre R.

; Serejo, Cristiana S.

; Garraffoni, André R.S.

; Santos, Adalberto J.

; Slipinski, Adam

; Linzmeier, Adelita M.

; Calor, Adolfo R.

; Garda, Adrian A.

; Kury, Adriano B.

; Fernandes, Agatha C.S.

; Agudo-Padrón, Aisur I.

; Akama, Alberto

; Silva Neto, Alberto M. da

; Burbano, Alejandro L.

; Menezes, Aleksandra

; Pereira-Colavite, Alessandre

; Anichtchenko, Alexander

; Lees, Alexander C.

; Bezerra, Alexandra M.R.

; Domahovski, Alexandre C.

; Pimenta, Alexandre D.

; Aleixo, Alexandre L.P.

; Marceniuk, Alexandre P.

; Paula, Alexandre S. de

; Somavilla, Alexandre

; Specht, Alexandre

; Camargo, Alexssandro

; Newton, Alfred F.

; Silva, Aline A.S. da

; Santos, Aline B. dos

; Tassi, Aline D.

; Aragão, Allan C.

; Santos, Allan P.M.

; Migotto, Alvaro E.

; Mendes, Amanda C.

; Cunha, Amanda

; Chagas Júnior, Amazonas

; Sousa, Ana A.T. de

; Pavan, Ana C.

; Almeida, Ana C.S.

; Peronti, Ana L.B.G.

; Henriques-Oliveira, Ana L.

; Prudente, Ana L.

; Tourinho, Ana L.

; Pes, Ana M.O.

; Carmignotto, Ana P.

; Wengrat, Ana P.G. da Silva

; Dornellas, Ana P.S.

; Molin, Anamaria Dal

; Puker, Anderson

; Morandini, André C.

; Ferreira, André da S.

; Martins, André L.

; Esteves, André M.

; Fernandes, André S.

; Roza, André S.

; Köhler, Andreas

; Paladini, Andressa

; Andrade, Andrey J. de

; Pinto, Ângelo P.

; Salles, Anna C. de A.

; Gondim, Anne I.

; Amaral, Antonia C.Z.

; Rondón, Antonio A.A.

; Brescovit, Antonio

; Lofego, Antônio C.

; Marques, Antonio C.

; Macedo, Antonio

; Andriolo, Artur

; Henriques, Augusto L.

; Ferreira Júnior, Augusto L.

; Lima, Aurino F. de

; Barros, Ávyla R. de A.

; Brito, Ayrton do R.

; Romera, Bárbara L.V.

; Vasconcelos, Beatriz M.C. de

; Frable, Benjamin W.

; Santos, Bernardo F.

; Ferraz, Bernardo R.

; Rosa, Brunno B.

; Sampaio, Brunno H.L.

; Bellini, Bruno C.

; Clarkson, Bruno

; Oliveira, Bruno G. de

; Corrêa, Caio C.D.

; Martins, Caleb C.

; Castro-Guedes, Camila F. de

; Souto, Camilla

; Bicho, Carla de L.

; Cunha, Carlo M.

; Barboza, Carlos A. de M.

; Lucena, Carlos A.S. de

; Barreto, Carlos

; Santana, Carlos D.C.M. de

; Agne, Carlos E.Q.

; Mielke, Carlos G.C.

; Caetano, Carlos H.S.

; Flechtmann, Carlos H.W.

; Lamas, Carlos J.E.

; Rocha, Carlos

; Mascarenhas, Carolina S.

; Margaría, Cecilia B.

; Waichert, Cecilia

; Digiani, Celina

; Haddad, Célio F.B.

; Azevedo, Celso O.

; Benetti, Cesar J.

; Santos, Charles M.D. dos

; Bartlett, Charles R.

; Bonvicino, Cibele

; Ribeiro-Costa, Cibele S.

; Santos, Cinthya S.G.

; Justino, Cíntia E.L.

; Canedo, Clarissa

; Bonecker, Claudia C.

; Santos, Cláudia P.

; Carvalho, Claudio J.B. de

; Gonçalves, Clayton C.

; Galvão, Cleber

; Costa, Cleide

; Oliveira, Cléo D.C. de

; Schwertner, Cristiano F.

; Andrade, Cristiano L.

; Pereira, Cristiano M.

; Sampaio, Cristiano

; Dias, Cristina de O.

; Lucena, Daercio A. de A.

; Manfio, Daiara

; Amorim, Dalton de S.

; Queiroz, Dalva L. de

; Colpani, Daniara

; Abbate, Daniel

; Aquino, Daniel A.

; Burckhardt, Daniel

; Cavallari, Daniel C.

; Prado, Daniel de C. Schelesky

; Praciano, Daniel L.

; Basílio, Daniel S.

; Bená, Daniela de C.

; Toledo, Daniela G.P. de

; Takiya, Daniela M.

; Fernandes, Daniell R.R.

; Ament, Danilo C.

; Cordeiro, Danilo P.

; Silva, Darliane E.

; Pollock, Darren A.

; Muniz, David B.

; Gibson, David I.

; Nogueira, David S.

; Marques, Dayse W.A.

; Lucatelli, Débora

; Garcia, Deivys M.A.

; Baêta, Délio

; Ferreira, Denise N.M.

; Rueda-Ramírez, Diana

; Fachin, Diego A.

; Souza, Diego de S.

; Rodrigues, Diego F.

; Pádua, Diego G. de

; Barbosa, Diego N.

; Dolibaina, Diego R.

; Amaral, Diogo C.

; Chandler, Donald S.

; Maccagnan, Douglas H.B.

; Caron, Edilson

; Carvalho, Edrielly

; Adriano, Edson A.

; Abreu Júnior, Edson F. de

; Pereira, Edson H.L.

; Viegas, Eduarda F.G.

; Carneiro, Eduardo

; Colley, Eduardo

; Eizirik, Eduardo

; Santos, Eduardo F. dos

; Shimbori, Eduardo M.

; Suárez-Morales, Eduardo

; Arruda, Eliane P. de

; Chiquito, Elisandra A.

; Lima, Élison F.B.

; Castro, Elizeu B. de

; Orlandin, Elton

; Nascimento, Elynton A. do

; Razzolini, Emanuel

; Gama, Emanuel R.R.

; Araujo, Enilma M. de

; Nishiyama, Eric Y.

; Spiessberger, Erich L.

; Santos, Érika C.L. dos

; Contreras, Eugenia F.

; Galati, Eunice A.B.

; Oliveira Junior, Evaldo C. de

; Gallardo, Fabiana

; Hernandes, Fabio A.

; Lansac-Tôha, Fábio A.

; Pitombo, Fabio B.

; Dario, Fabio Di

; Santos, Fábio L. dos

; Mauro, Fabio

; Nascimento, Fabio O. do

; Olmos, Fabio

; Amaral, Fabio R.

; Schunck, Fabio

; Godoi, Fábio S. P. de

; Machado, Fabrizio M.

; Barbo, Fausto E.

; Agrain, Federico A.

; Ribeiro, Felipe B.

; Moreira, Felipe F.F.

; Barbosa, Felipe F.

; Silva, Fenanda S.

; Cavalcanti, Fernanda F.

; Straube, Fernando C.

; Carbayo, Fernando

; Carvalho Filho, Fernando

; Zanella, Fernando C.V.

; Jacinavicius, Fernando de C.

; Farache, Fernando H.A.

; Leivas, Fernando

; Dias, Fernando M.S.

; Mantellato, Fernando

; Vaz-de-Mello, Fernando Z.

; Gudin, Filipe M.

; Albuquerque, Flávio

; Molina, Flavio B.

; Passos, Flávio D.

; Shockley, Floyd W.

; Pinheiro, Francielly F.

; Mello, Francisco de A.G. de

; Nascimento, Francisco E. de L.

; Franco, Francisco L.

; Oliveira, Francisco L. de

; Melo, Francisco T. de V.

; Quijano, Freddy R.B.

; Salles, Frederico F.

; Biffi, Gabriel

; Queiroz, Gabriel C.

; Bizarro, Gabriel L.

; Hrycyna, Gabriela

; Leviski, Gabriela

; Powell, Gareth S.

; Santos, Geane B. dos

; Morse, Geoffrey E.

; Brown, George

; Mattox, George M.T.

; Zimbrão, Geraldo

; Carvalho, Gervásio S.

; Miranda, Gil F.G.

; Moraes, Gilberto J. de

; Lourido, Gilcélia M.

; Neves, Gilmar P.

; Moreira, Gilson R.P.

; Montingelli, Giovanna G.

; Maurício, Giovanni N.

; Marconato, Gláucia

; Lopez, Guilherme E.L.

; Silva, Guilherme L. da

; Muricy, Guilherme

; Brito, Guilherme R.R.

; Garbino, Guilherme S.T.

; Flores, Gustavo E.

; Graciolli, Gustavo

; Libardi, Gustavo S.

; Proctor, Heather C.

; Gil-Santana, Helcio R.

; Varella, Henrique R.

; Escalona, Hermes E.

; Schmitz, Hermes J.

; Rodrigues, Higor D.D.

; Galvão Filho, Hilton de C.

; Quintino, Hingrid Y.S.

; Pinto, Hudson A.

; Rainho, Hugo L.

; Miyahira, Igor C.

; Gonçalves, Igor de S.

; Martins, Inês X.

; Cardoso, Irene A.

; Oliveira, Ismael B. de

; Franz, Ismael

; Fernandes, Itanna O.

; Golfetti, Ivan F.

; S. Campos-Filho, Ivanklin

; Oliveira, Ivo de S.

; Delabie, Jacques H.C.

; Oliveira, Jader de

; Prando, Jadila S.

; Patton, James L.

; Bitencourt, Jamille de A.

; Silva, Janaina M.

; Santos, Jandir C.

; Arruda, Janine O.

; Valderrama, Jefferson S.

; Dalapicolla, Jeronymo

; Oliveira, Jéssica P.

; Hájek, Jiri

; Morselli, João P.

; Narita, João P.

; Martin, João P.I.

; Grazia, Jocélia

; McHugh, Joe

; Cherem, Jorge J.

; Farias Júnior, José A.S.

; Fernandes, Jose A.M.

; Pacheco, José F.

; Birindelli, José L.O.

; Rezende, José M.

; Avendaño, Jose M.

; Duarte, José M. Barbanti

; Ribeiro, José R. Inácio

; Mermudes, José R.M.

; Pujol-Luz, José R.

; Santos, Josenilson R. dos

; Câmara, Josenir T.

; Teixeira, Joyce A.

; Prado, Joyce R. do

; Botero, Juan P.

; Almeida, Julia C.

; Kohler, Julia

; Gonçalves, Julia P.

; Beneti, Julia S.

; Donahue, Julian P.

; Alvim, Juliana

; Almeida, Juliana C.

; Segadilha, Juliana L.

; Wingert, Juliana M.

; Barbosa, Julianna F.

; Ferrer, Juliano

; Santos, Juliano F. dos

; Kuabara, Kamila M.D.

; Nascimento, Karine B.

; Schoeninger, Karine

; Campião, Karla M.

; Soares, Karla

; Zilch, Kássia

; Barão, Kim R.

; Teixeira, Larissa

; Sousa, Laura D. do N.M. de

; Dumas, Leandro L.

; Vieira, Leandro M.

; Azevedo, Leonardo H.G.

; Carvalho, Leonardo S.

; Souza, Leonardo S. de

; Rocha, Leonardo S.G.

; Bernardi, Leopoldo F.O.

; Vieira, Letícia M.

; Johann, Liana

; Salvatierra, Lidianne

; Oliveira, Livia de M.

; Loureiro, Lourdes M.A. El-moor

; Barreto, Luana B.

; Barros, Luana M.

; Lecci, Lucas

; Camargos, Lucas M. de

; Lima, Lucas R.C.

; Almeida, Lucia M.

; Martins, Luciana R.

; Marinoni, Luciane

; Moura, Luciano de A.

; Lima, Luciano

; Naka, Luciano N.

; Miranda, Lucília S.

; Salik, Lucy M.

; Bezerra, Luis E.A.

; Silveira, Luis F.

; Campos, Luiz A.

; Castro, Luiz A.S. de

; Pinho, Luiz C.

; Silveira, Luiz F.L.

; Iniesta, Luiz F.M.

; Tencatt, Luiz F.C.

; Simone, Luiz R.L.

; Malabarba, Luiz R.

; Cruz, Luiza S. da

; Sekerka, Lukas

; Barros, Lurdiana D.

; Santos, Luziany Q.

; Skoracki, Maciej

; Correia, Maira A.

; Uchoa, Manoel A.

; Andrade, Manuella F.G.

; Hermes, Marcel G.

; Miranda, Marcel S.

; Araújo, Marcel S. de

; Monné, Marcela L.

; Labruna, Marcelo B.

; Santis, Marcelo D. de

; Duarte, Marcelo

; Knoff, Marcelo

; Nogueira, Marcelo

; Britto, Marcelo R. de

; Melo, Marcelo R.S. de

; Carvalho, Marcelo R. de

; Tavares, Marcelo T.

; Kitahara, Marcelo V.

; Justo, Marcia C.N.

; Botelho, Marcia J.C.

; Couri, Márcia S.

; Borges-Martins, Márcio

; Felix, Márcio

; Oliveira, Marcio L. de

; Bologna, Marco A.

; Gottschalk, Marco S.

; Tavares, Marcos D.S.

; Lhano, Marcos G.

; Bevilaqua, Marcus

; Santos, Marcus T.T.

; Domingues, Marcus V.

; Sallum, Maria A.M.

; Digiani, María C.

; Santarém, Maria C.A.

; Nascimento, Maria C. do

; Becerril, María de los A.M.

; Santos, Maria E.A. dos

; Passos, Maria I. da S. dos

; Felippe-Bauer, Maria L.

; Cherman, Mariana A.

; Terossi, Mariana

; Bartz, Marie L.C.

; Barbosa, Marina F. de C.

; Loeb, Marina V.

; Cohn-Haft, Mario

; Cupello, Mario

; Martins, Marlúcia B.

; Christofersen, Martin L.

; Bento, Matheus

; Rocha, Matheus dos S.

; Martins, Maurício L.

; Segura, Melissa O.

; Cardenas, Melissa Q.

; Duarte, Mércia E.

; Ivie, Michael A.

; Mincarone, Michael M.

; Borges, Michela

; Monné, Miguel A.

; Casagrande, Mirna M.

; Fernandez, Monica A.

; Piovesan, Mônica

; Menezes, Naércio A.

; Benaim, Natalia P.

; Reategui, Natália S.

; Pedro, Natan C.

; Pecly, Nathalia H.

; Ferreira Júnior, Nelson

; Silva Júnior, Nelson J. da

; Perioto, Nelson W.

; Hamada, Neusa

; Degallier, Nicolas

; Chao, Ning L.

; Ferla, Noeli J.

; Mielke, Olaf H.H.

; Evangelista, Olivia

; Shibatta, Oscar A.

; Oliveira, Otto M.P.

; Albornoz, Pablo C.L.

; Dellapé, Pablo M.

; Gonçalves, Pablo R.

; Shimabukuro, Paloma H.F.

; Grossi, Paschoal

; Rodrigues, Patrícia E. da S.

; Lima, Patricia O.V.

; Velazco, Paul

; Santos, Paula B. dos

; Araújo, Paula B.

; Silva, Paula K.R.

; Riccardi, Paula R.

; Garcia, Paulo C. de A.

; Passos, Paulo G.H.

; Corgosinho, Paulo H.C.

; Lucinda, Paulo

; Costa, Paulo M.S.

; Alves, Paulo P.

; Roth, Paulo R. de O.

; Coelho, Paulo R.S.

; Duarte, Paulo R.M.

; Carvalho, Pedro F. de

; Gnaspini, Pedro

; Souza-Dias, Pedro G.B.

; Linardi, Pedro M.

; Bartholomay, Pedro R.

; Demite, Peterson R.

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; Boll, Piter K.

; Pereira, Rachel M.M.

; Silva, Rafael A.P.F.

; Moura, Rafael B. de

; Boldrini, Rafael

; Silva, Rafaela A. da

; Falaschi, Rafaela L.

; Cordeiro, Ralf T.S.

; Mello, Ramon J.C.L.

; Singer, Randal A.

; Querino, Ranyse B.

; Heleodoro, Raphael A.

; Castilho, Raphael de C.

; Constantino, Reginaldo

; Guedes, Reinaldo C.

; Carrenho, Renan

; Gomes, Renata S.

; Gregorin, Renato

; Machado, Renato J.P.

; Bérnils, Renato S.

; Capellari, Renato S.

; Silva, Ricardo B.

; Kawada, Ricardo

; Dias, Ricardo M.

; Siewert, Ricardo

; Brugnera, Ricaro

; Leschen, Richard A.B.

; Constantin, Robert

; Robbins, Robert

; Pinto, Roberta R.

; Reis, Roberto E. dos

; Ramos, Robson T. da C.

; Cavichioli, Rodney R.

; Barros, Rodolfo C. de

; Caires, Rodrigo A.

; Salvador, Rodrigo B.

; Marques, Rodrigo C.

; Araújo, Rodrigo C.

; Araujo, Rodrigo de O.

; Dios, Rodrigo de V.P.

; Johnsson, Rodrigo

; Feitosa, Rodrigo M.

; Hutchings, Roger W.

; Lara, Rogéria I.R.

; Rossi, Rogério V.

; Gerstmeier, Roland

; Ochoa, Ronald

; Hutchings, Rosa S.G.

; Ale-Rocha, Rosaly

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; Tidon, Rosana

; Brito, Rosangela

; Pellens, Roseli

; Santos, Sabrina R. dos

; Santos, Sandra D. dos

; Paiva, Sandra V.

; Santos, Sandro

; Oliveira, Sarah S. de

; Costa, Sávio C.

; Gardner, Scott L.

; Leal, Sebastián A. Muñoz

; Aloquio, Sergio

; Bonecker, Sergio L.C.

; Bueno, Sergio L. de S.

; Almeida, Sérgio M. de

; Stampar, Sérgio N.

; Andena, Sérgio R.

; Posso, Sergio R.

; Lima, Sheila P.

; Gadelha, Sian de S.

; Thiengo, Silvana C.

; Cohen, Simone C.

; Brandão, Simone N.

; Rosa, Simone P.

; Ribeiro, Síria L.B.

; Letana, Sócrates D.

; Santos, Sonia B. dos

; Andrade, Sonia C.S.

; Dávila, Stephane

; Vaz, Stéphanie

; Peck, Stewart B.

; Christo, Susete W.

; Cunha, Suzan B.Z.

; Gomes, Suzete R.

; Duarte, Tácio

; Madeira-Ott, Taís

; Marques, Taísa

; Roell, Talita

; Lima, Tarcilla C. de

; Sepulveda, Tatiana A.

; Maria, Tatiana F.

; Ruschel, Tatiana P.

; Rodrigues, Thaiana

; Marinho, Thais A.

; Almeida, Thaís M. de

; Miranda, Thaís P.

; Freitas, Thales R.O.

; Pereira, Thalles P.L.

; Zacca, Thamara

; Pacheco, Thaynara L.

; Martins, Thiago F.

; Alvarenga, Thiago M.

; Carvalho, Thiago R. de

; Polizei, Thiago T.S.

; McElrath, Thomas C.

; Henry, Thomas

; Pikart, Tiago G.

; Porto, Tiago J.

; Krolow, Tiago K.

; Carvalho, Tiago P.

; Lotufo, Tito M. da C.

; Caramaschi, Ulisses

; Pinheiro, Ulisses dos S.

; Pardiñas, Ulyses F.J.

; Maia, Valéria C.

; Tavares, Valeria

; Costa, Valmir A.

; Amaral, Vanessa S. do

; Silva, Vera C.

; Wolff, Vera R. dos S.

; Slobodian, Verônica

; Silva, Vinícius B. da

; Espíndola, Vinicius C.

; Costa-Silva, Vinicius da

; Bertaco, Vinicius de A.

; Padula, Vinícius

; Ferreira, Vinicius S.

; Silva, Vitor C.P. da

; Piacentini, Vítor de Q.

; Sandoval-Gómez, Vivian E.

; Trevine, Vivian

; Sousa, Viviane R.

; Sant’Anna, Vivianne B. de

; Mathis, Wayne N.

; Souza, Wesley de O.

; Colombo, Wesley D.

; Tomaszewska, Wioletta

; Wosiacki, Wolmar B.

; Ovando, Ximena M.C.

; Leite, Yuri L.R.

Zoologia (Curitiba)

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2024, Volume 41 elocation e24005

Abstract: En | Text: En | PDF: En

ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7

https://doi.org/10.1590/s1984-4689.v41.e24005

13.

Evaluation of the effects of an emulsifier and two lipid sources on growth performance and intestinal morphology of broiler chickens
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Oliveira, Marcus Vinícius Garcia de

; Silva, Júlia Marixara Sousa da

; Batista, João Marcos Monteiro

; Café, Marcos Barcellos

; Mello, Heloisa Helena de Carvalho

; Oliveira, Helder Freitas de

; Pires, Marília Ferreira

; Leandro, Nadja Susana Mogyca

; Jacob, David Vanni

Revista Brasileira de Zootecnia

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2024, Volume 53 elocation e20230087

Abstract: En | Text: En | PDF: En

ABSTRACT This study aimed to evaluate the effect of including an emulsifier (soybean lecithin) and two lipid sources (soybean oil and chicken fat) on the performance and intestinal morphology of broiler chickens. A total of 576 one-day-old Cobb® 500 male chicks were housed in a completely randomized design, with treatments divided in a 2 × 2 factorial arrangement (with and without emulsifier and two lipid sources – soybean oil or chicken fat), totaling four treatments with eight replications and 18 chicks per plot. The experimental diets were formulated to be isoenergetic and isoproteic. The use of chicken fat improved the live weight at the starter rearing stage. However, the use of the emulsifier improved the live weight at the grower and finisher phases. No interaction effect was observed between treatments for performance. The intestinal morphology showed an increase in duodenal villus height with the use of chicken fat and emulsifier. The ileum had an increase in villus height in chickens fed the diet with soybean oil and emulsifier. Supplementation of the emulsifier resulted in positive results in the live weight of chickens at 35 and 42 days of age, in addition to increasing the villus height in the small intestine. lecithin 57 onedayold one day old Cobb 50 design fat, , 1 plot isoproteic stage However phases 3 4 age intestine 5

https://doi.org/10.37496/rbz5320230087

14.

Infarto Agudo do Miocárdio com Supradesnível de ST e Terapia de Reperfusão no Brasil: Dados do Registro ACCEPT Brasil
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Ritt, Luiz Eduardo Fonteles

; Silva, Pedro Gabriel Melo de Barros e

; Darzé, Eduardo Sahade

; Santos, Renato Hideo Nakagawa

; de Oliveira, Queila Borges

; Berwanger, Otavio

; Mattos, Luiz Alberto Piva e

; dos Santos, Elizabete Silva

; Souza, Antonio Carlos Sobral

; Cavalcante, Margaret Assad

; de Andrade, Pedro Beraldo

; Neuenschwander, Fernando Carvalho

; Vargas Filho, Hugo

; Guimarães, Jorge Ilha

; de Andrade, Jadelson Pinheiro

; de Paola, Angelo Amato Vincenzo

; Malachias, Marcus Vinícius Bolívar

; Précoma, Dalton Bertolim

; Bacal, Fernando

; Dutra, Oscar Pereira

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 11 elocation e20230863

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO Fundamento: Há carência de informações nacionais em relação a terapias utilizadas e evolução nos pacientes com síndrome coronária aguda com elevação de ST (SCACEST). Objetivos: Avaliar as terapias baseadas em evidência, a ocorrência de desfechos, uso de reperfusão e preditores para não receber reperfusão nos pacientes com SCACEST em um registro nacional multicêntrico. Métodos: Pacientes com SCACEST do Registro ACCEPT com até 12 horas de sintomas foram seguidos por 1 ano para ocorrência de eventos cardiovasculares maiores. Um p < 0,05 foi aplicado para todas análises. Resultados: Na análise de 1.553 pacientes, a taxa de reperfusão foi de 76,8%, variando de 47,5% na região Norte a até 80,5% na região Sudeste. A taxa de eventos cardiovasculares maiores foi de 12,5% em 1 ano. A prescrição de terapias baseadas em evidência na admissão hospitalar foi de 65,6%. A presença de hipertensão (odds ratio [OR] 1,47; intervalo de confiança [IC] 95% 1,11 a 1,96; p < 0,01), infarto agudo do miocárdio prévio (OR 1,81; IC 95% 1,32 a 2,48; p < 0,001) e as regiões Norte (OR 4,65; IC 95% 2,87 a 7,52; p < 0,001), Centro-Oeste (OR 4,02 IC 95% 1,26 a 12,7; p < 0,05) e Nordeste (OR 1,70; IC 95% 1,17 a 2,46; p < 0,01) foram preditores independentes de não utilização de terapia de reperfusão. Conclusões: No seguimento de 1 ano do Registro ACCEPT podemos verificar uma ampla variação dentre as regiões no que tange a aderência às melhores práticas de cuidado. Ser atendido nas regiões Norte, Centro-Oeste ou Nordeste, ter hipertensão arterial sistêmica ou infarto prévio foram preditores independentes de não utilização de terapia de reperfusão. Fundamento SCACEST. . (SCACEST) Objetivos desfechos multicêntrico Métodos 005 0 05 0,0 análises Resultados 1553 553 1.55 768 76 8 76,8% 475 47 5 47,5 805 80 80,5 Sudeste 125 12,5 656 65 6 65,6% odds OR [OR 1,47 147 [IC 95 111 11 1,1 1,96 196 96 0,01, 001 0,01 , 01 1,81 181 81 132 32 1,3 2,48 248 2 48 0,001 0001 4,65 465 4 287 87 2,8 7,52 752 7 52 0,001, CentroOeste Centro Oeste 402 02 4,0 126 26 1,2 12,7 127 1,70 170 70 117 17 2,46 246 46 Conclusões cuidado (SCACEST 00 0, 155 55 1.5 76,8 47, 80, 12, 65,6 1,4 14 9 1, 1,9 19 1,8 18 13 3 2,4 24 0,00 000 4,6 28 2, 7,5 75 40 4, 1,7 15 1. 76, 65, 7,

ABSTRACT Background: There is a lack of information from Brazil regarding therapies used and outcomes in patients with acute coronary syndrome with ST elevation (STEMI). Objectives: To evaluate evidence-based therapies, occurrence of outcomes, reperfusion use, and predictors of not receiving reperfusion in patients with STEMI in a national multicenter registry. Methods: Patients with STEMI from the ACCEPT registry, with up to 12 hours of symptoms, were followed for 1 year for the occurrence of major adverse cardiovascular events. A significance level of p < 0.05 was applied for all analyses. Results: In the analysis of 1553 patients, the reperfusion rate was 76.8%, ranging from 47.5% in the North Region to 80.5% in the Southeast Region. The rate of major adverse cardiovascular events was 12.5% at 1 year. The prescription of evidence-based therapies at hospital admission was 65.6%. The presence of hypertension (odds ratio [OR] 1.47; 95% confidence interval [CI] 1.11 to 1.96; p < 0.01); prior acute myocardial infarction (OR 1.81; 95% CI 1.32 to 2.48; p < 0.001); and the North (OR 4.65; 95% CI 2.87 to 7.52; p < 0.001), Central-West (OR 4.02; 95% CI 1.26 to 12.7; p < 0.05), and Northeast Regions (OR 1.70; 95% CI 1.17 to 2.46; p < 0.01) were independent predictors of not receiving reperfusion therapy. Conclusion: In the 1-year follow-up of the ACCEPT Registry, we were able to verify a wide variation within Brazilian geographical regions regarding adherence to best care practices. The following were independent predictors of not receiving reperfusion therapy: being treated in the North, Central-West, and Northeast Regions; having systemic arterial hypertension; and prior infarction. Background STEMI. . (STEMI) Objectives evidencebased evidence based use registry Methods symptoms 005 0 05 0.0 analyses Results 155 768 76 8 76.8% 475 47 5 47.5 805 80 80.5 125 12.5 656 65 6 65.6% odds OR [OR 1.47 147 95 [CI 111 11 1.1 1.96 196 96 0.01 001 01 1.81 181 81 132 32 1.3 2.48 248 2 48 0.001 0001 0.001) 4.65 465 4 287 87 2.8 7.52 752 7 52 0.001, , CentralWest Central West 4.02 402 02 126 26 1.2 12.7 127 0.05, 0.05) 1.70 170 70 117 17 2.46 246 46 therapy Conclusion 1year followup follow Registry practices CentralWest, West, (STEMI 00 0. 15 76.8 47. 80. 12. 65.6 1.4 14 9 1. 1.9 19 1.8 18 13 3 2.4 24 0.00 000 4.6 28 2. 7.5 75 4.0 40 1.7 76. 65. 4. 7.

https://doi.org/10.36660/abc.20230863

15.

Risco de Desfechos Adversos à Saúde em Pacientes com Baixa Adesão ao Tratamento Medicamentoso Cardiovascular: Uma Revisão Sistemática Cardiovascular
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Malachias, Marcus Vinícius Bolívar

; Kaiser, Sergio Emanuel

; Albuquerque, Denilson Campos de

; Brandão, Andrea Araújo

; Sposito, Andrei Carvalho

; Moura, Lidia Zytysnky

; Magalhães, Lucélia Batista Neves Cunha

; Mota-Gomes, Marco Antonio

; Clausell, Nadine

; Jardim, Paulo César Veiga

; Nadruz, Wilson

; Barros, Bruno Monteiro

; Luna, Leonardo Castro

; Barroso, Weimar Kunz Sebba

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 N. 10 elocation e20240469

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Fundamento As doenças cardiovasculares (DCV) são a principal causa de mortes no mundo. A adesão ao tratamento medicamentoso é um fator importante no manejo de DCV crônicas, influenciando diretamente a ocorrência de desfechos e custos da saúde. Objetivos Esta revisão sistemática, apoiada pela Sociedade Brasileira de Cardiologia, tem como objetivo avaliar o impacto da baixa adesão aos medicamentos para DCV sobre desfechos clínicos críticos como morte e eventos cardiovasculares. Métodos Foi realizada uma busca abrangente em quatro bases de dados: Medline, Embase, Lilacs e Cochrane. Foram incluídas revisões sistemáticas e metanálises que avaliaram estimativas de risco para adesão aos medicamentos cardiovasculares. Quatro revisões sistemáticas, cada uma incorporando estudos observacionais, foram selecionadas. Resultados O aumento na adesão aos medicamentos reduz significativamente o risco de eventos cardiovasculares, acidente vascular cerebral (AVC) e morte por todas as causas. Uma melhoria de 20% na adesão a medicamentos anti-hipertensivos, hipolipemiantes e outros medicamentos cardiovasculares foi correlacionada com reduções nos eventos cardiovasculares em 7%, 10% e 9%, respectivamente; AVC em 17%, 13% e 18%; e morte em 12%, 9% e 10%. A certeza das evidências foi moderada, sugerindo que esses efeitos provavelmente estão presentes. Esses achados enfatizam a necessidade de aumentar a adesão aos tratamentos para melhorar os desfechos clínicos no manejo das DCV. Conclusões Evidências demonstraram reduções em morte e desfechos críticos, tanto na prevenção primária quanto na secundária, por meio do controle de condições como hipertensão e colesterol LDL elevado, assim como benefícios da terapia antiplaquetária na doença aterosclerótica. Mais estudos são necessários para melhor elucidar a relação entre a adesão aos medicamentos cardiovasculares e a melhora de desfechos clínicos críticos. (DCV mundo crônicas saúde sistemática Cardiologia dados Medline Embase Cochrane observacionais selecionadas (AVC causas 20 antihipertensivos, antihipertensivos anti hipertensivos, hipertensivos anti-hipertensivos 7 7% 10 9 respectivamente 17 17% 13 18% 18 12 12% moderada presentes secundária elevado aterosclerótica 2 1

Abstract Background Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. Medication adherence is an important issue in managing chronic CVD, directly influencing outcomes and healthcare costs. Objectives This systematic review, supported by the Brazilian Society of Cardiology, evaluates the impact of poor adherence to cardiovascular medications on critical clinical outcomes such as death and cardiovascular events. Methods A comprehensive search was conducted across four databases, including Medline, Embase, Lilacs, and the Cochrane Library. The review included systematic reviews with meta-analyses that reported risk estimates for adherence to cardiovascular medications. Four systematic reviews, each incorporating observational studies, were selected. Results An increase in adherence to medications significantly reduces the risk of cardiovascular events, stroke, and all-cause death. Specifically, a 20% improvement in adherence to antihypertensive, lipid-lowering, and other cardiovascular medications correlated with reductions in cardiovascular events by 7%, 10%, and 9%, respectively; stroke by 17%, 13%, and 18%; and death by 12%, 9%, and 10%. The certainty of the evidence was moderate, suggesting that these effects are likely present. These findings emphasize the importance of enhancing medication adherence to improve clinical outcomes in CVD management. Conclusions Evidence has demonstrated reductions in hard endpoints in both primary and secondary prevention through the control of conditions such as hypertension and elevated LDL cholesterol concentrations, as well as the benefits of antiplatelet therapy in atherosclerotic disease. However, additional studies are needed to better elucidate the relationship between adherence to cardiovascular medications and the improvement of critical clinical outcomes. (CVD worldwide costs Cardiology databases Medline Embase Lilacs Library metaanalyses meta analyses selected allcause all Specifically 20 antihypertensive lipidlowering, lipidlowering lipid lowering, lowering lipid-lowering 7 7% 10 10% 9 9% respectively 17 17% 13 13% 18% 18 12 12% moderate present management concentrations disease However 2 1

https://doi.org/10.36660/abc.20240469

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