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RESUMO Objetivo: Analisar as prevalências de acidentes de trabalho, segundo variáveis sociodemográficas e ocupacionais, em 2013 e 2019. Métodos: Estudo transversal utilizando dados da Pesquisa Nacional de Saúde (PNS) 2013 e 2019. Avaliou-se os acidentes de trabalho típico (AT), de descolamento (AD) e de trabalho totais (ATT). As prevalências e os intervalos de confiança de 95% (IC95%) de ATT em 2013 e 2019 foram estimadas segundo as variáveis explicativas, unidades da Federação e capitais. Em 2019, foram calculadas as prevalências e IC95% segundo variáveis explicativas e razões de prevalência (RP) bruta e ajustada por sexo e faixa etária. Resultados: A prevalência de ATT passou de 4,96% (IC95% 4,55–5,38) em 2013 para 4,13% (IC95% 3,80–4,46) em 2019. Em 2013, o Pará liderou em prevalência de ATT e, em 2019, a maior prevalência foi em Mato Grosso. As prevalências de AT e AD em 2019 foram, respectivamente, 2,64% (IC95% 2,37–2,91) e 1,60% (IC95% 1,40–1,80). Em 2019, as prevalências para ATT foram mais elevadas para homens (RP: 1,92; IC95% 1,62–2,27); faixa etária de 18 a 29 anos (RP: 2,71; IC95% 1,99–3,68); pessoas com ensino fundamental completo/médio incompleto (RP: 2,09; IC95% 1,57–2,78); e pessoas de cor preta (RP: 1,43; IC95% 1,12–1, 84), e menor em pessoas sem carteira de trabalho (RP: 0,77; IC95% 0,66–0,90). AT foi maior na zona rural (RP: 1,32; IC95% 1,09–1,60). Conclusão: Houve redução dos ATT entre 2013 e 2019. Homens, jovens, pretos e indivíduos com menor escolaridade, trabalhadores da zona rural, apresentaram maiores prevalências de AT em 2019, demonstrando uma relação dos processos saúde-doença-acidente. Objetivo ocupacionais 201 Métodos PNS (PNS Avaliouse Avaliou se AT, , (AT) (AD ATT. . (ATT) 95 IC95 IC capitais RP (RP Resultados 496 4 96 4,96 (IC95 4,55–5,38 455538 55 5 38 413 13 4,13 3,80–4,46 380446 3 80 46 Grosso respectivamente 264 2 64 2,64 2,37–2,91 237291 37 91 160 1 60 1,60 1,40–1,80. 140180 1,40–1,80 40 1,40–1,80) 1,92 192 92 1,62–2,27 162227 62 27 1,62–2,27) 2,71 271 71 1,99–3,68 199368 99 68 1,99–3,68) completomédio completo médio 2,09 209 09 1,57–2,78 157278 57 78 1,57–2,78) 1,43 143 43 1121 12 1,12–1 84, 84 84) 0,77 077 0 77 0,66–0,90. 066090 0,66–0,90 66 90 0,66–0,90) 1,32 132 32 1,09–1,60. 109160 1,09–1,60 1,09–1,60) Conclusão Homens jovens escolaridade saúdedoençaacidente. saúdedoençaacidente saúde doença acidente. acidente saúde-doença-acidente 20 (AT (ATT 9 IC9 49 4,9 (IC9 4,55–5,3 45553 41 4,1 3,80–4,4 38044 8 26 6 2,6 2,37–2,9 23729 16 1,6 14018 1,40–1,8 1,9 19 1,62–2,2 16222 2,7 7 1,99–3,6 19936 2,0 1,57–2,7 15727 1,4 14 112 1,12– 0,7 07 06609 0,66–0,9 1,3 10916 1,09–1,6 4, (IC 4,55–5, 4555 3,80–4, 3804 2, 2,37–2, 2372 1, 1401 1,40–1, 1,62–2, 1622 1,99–3, 1993 1,57–2, 1572 11 1,12 0, 0660 0,66–0, 1091 1,09–1, 4,55–5 455 3,80–4 380 2,37–2 237 140 1,40–1 1,62–2 162 1,99–3 199 1,57–2 157 1,1 066 0,66–0 109 1,09–1 4,55– 45 3,80– 2,37– 23 1,40– 1,62– 1,99– 1,57– 15 06 0,66– 10 1,09– 4,55 3,80 2,37 1,40 1,62 1,99 1,57 0,66 1,09 4,5 3,8 2,3 1,5 0,6 1,0 3,

ABSTRACT Objective: To analyze the prevalence of work-related accidents, according to sociodemographic and occupational variables, in 2013 and 2019. Methods: Cross-sectional study using data from the National Survey of Health (PNS) 2013 and 2019. Typical work accidents (WA), commuting accidents (CA), and Total Work Accidents (TWA) were evaluated. Prevalence values and 95% confidence intervals (95%CI) of TWA in 2013 and 2019 were estimated according to the explanatory variables and for Federative Units and capitals. In 2019, the prevalence and 95%CI according to explanatory variables were estimated using prevalence ratios (PR), both crude and adjusted for sex and age group. Results: TWA prevalence decreased from 4.96% (95%CI 4.55–5.38) in 2013 to 4.13% (95%CI 3.80–4.46) in 2019. In 2013, the state of Pará prevailed in TWA, and the state of Mato Grosso in 2019. The prevalence of WA and CA in 2019 were: 2.64% (95%CI 2.37–2.91) and 1.60% (95%CI 1.40–1.80). In 2019, the prevalence for TWA were higher for men (PR: 1.92; 95%CI 1.62–2.27); in the 18-29 age group (PR: 2.71; 95%CI 1.99–3.68); people with elementary school and some high school (PR: 2.09; 95%CI 1.57–2.78); and Black individuals (PR: 1.43; 95%CI 1.12–1.84). People without formal employment contract had a lower prevalence of TWA (PR: 0.77; 95%CI 0.66–0.90). WA was higher in rural areas (PR: 1.32; 95%CI 1.09–1.60). Conclusion: There was a reduction in TWA between 2013 and 2019. Men, young people, Black people, and individuals with lower level of education, residents in rural areas had higher prevalence of WA in 2019, demonstrating a relationship between health-disease-accident processes. Objective workrelated related 201 Methods Crosssectional Cross sectional PNS (PNS WA, , (WA) CA, (CA) (TWA evaluated 95 95CI CI capitals PR, PR (PR) Results 496 4 96 4.96 4.55–5.38 455538 55 5 38 413 13 4.13 3.80–4.46 380446 3 80 46 264 2 64 2.64 2.37–2.91 237291 37 91 160 1 60 1.60 1.40–1.80. 140180 1.40–1.80 . 40 1.40–1.80) (PR 1.92 192 92 1.62–2.27 162227 62 27 1.62–2.27) 1829 18 29 18-2 2.71 271 71 1.99–3.68 199368 99 68 1.99–3.68) 2.09 209 09 1.57–2.78 157278 57 78 1.57–2.78) 1.43 143 43 1.12–1.84. 112184 1.12–1.84 12 84 1.12–1.84) 0.77 077 0 77 0.66–0.90. 066090 0.66–0.90 66 90 0.66–0.90) 1.32 132 32 1.09–1.60. 109160 1.09–1.60 1.09–1.60) Conclusion Men education healthdiseaseaccident health disease accident processes 20 (WA (CA 9 49 4.9 4.55–5.3 45553 41 4.1 3.80–4.4 38044 8 26 6 2.6 2.37–2.9 23729 16 1.6 14018 1.40–1.8 1.9 19 1.62–2.2 16222 182 18- 2.7 7 1.99–3.6 19936 2.0 1.57–2.7 15727 1.4 14 11218 1.12–1.8 0.7 07 06609 0.66–0.9 1.3 10916 1.09–1.6 4. 4.55–5. 4555 3.80–4. 3804 2. 2.37–2. 2372 1. 1401 1.40–1. 1.62–2. 1622 1.99–3. 1993 1.57–2. 1572 1121 1.12–1. 0. 0660 0.66–0. 1091 1.09–1. 4.55–5 455 3.80–4 380 2.37–2 237 140 1.40–1 1.62–2 162 1.99–3 199 1.57–2 157 112 1.12–1 066 0.66–0 109 1.09–1 4.55– 45 3.80– 2.37– 23 1.40– 1.62– 1.99– 1.57– 15 11 1.12– 06 0.66– 10 1.09– 4.55 3.80 2.37 1.40 1.62 1.99 1.57 1.12 0.66 1.09 4.5 3.8 2.3 1.5 1.1 0.6 1.0 3.

https://doi.org/10.1590/1980-549720230006.supl.1

[SciELO Preprints] - Commuting and work accidents among occupied Brazilians, National Health Survey 2013 and 2019
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Malta, Deborah Carvalho Bernal, Regina Tomie Ivata Vasconcelos, Nádia Machado de Ribeiro, Adalgisa Peixoto Vasconcelos, Lêda Lúcia Couto de Machado, Elaine Leandro

Journal Metrics
- Sobre o periódico
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Publication date: 2022-12-15

Abstract: En Pt

Objective: To analyze the prevalence of accidents at work, according to sociodemographic and occupational variables, in 2013 and 2019. Methods: Cross-sectional study using data from the National Health Survey (PNS) 2013 and 2019. Typical work accidents (WA), detachment (DA) and Total Work Accidents (WAT) were evaluated.  The prevalence and 95% confidence intervals (95%CI) of WAT in 2013 and 2019 were estimated according the explanatory variables and for Federation Units and capitals. In 2019, the prevalence and 95%CI according to the explanatory variables were calculated using crude and adjusted for sex and age group prevalence ratios (PR). Results: WAT prevalence increased from 4.96% (95%CI: 4.55-5.38) in 2013 to 4.13% (95%CI: 3.80-4.46) in 2019. In 2013, Para led in prevalence of WAT, and Mato Grosso in 2019. The prevalence of WA and AD in 2019 were: 2.64% (95%CI: 2.37-2.91) and 1.60% (95%CI: 1.40-1.80). In 2019, the prevalence for WAT were higher for men (PR: 1.92; 95%CI 1.62-2.27); in 18-29 age group (PR: 2.71; 95%CI 1.99-3.68); people with complete elementary school and incomplete high school (PR: 2.09; 95%CI 1.57-2.78); and black (RP: 1.43; 95%CI 1.12-1.84). People without a formal contract had a lower prevalence of RTA (PR: 0.77; 95%CI 0.66-0.90). AT was higher in rural areas (PR: 1.32 (1.09-1.60). Conclusion: There was a reduction in WAT between 2013 and 2019. Men, young people, black people and individuals with less education, residents in rural area had higher prevalence of WA in 2019, demonstrating a relationship between health-disease-accident processes.

Objetivo: Analisar as prevalências de acidentes de trabalho, segundo variáveis sociodemográficas e ocupacionais, em 2013 e 2019. Métodos: Estudo transversal utilizando dados da Pesquisa Nacional de Saúde (PNS) 2013 e 2019. Avaliou-se os acidentes de trabalho típico (AT), descolamento (AD) e Acidentes de Trabalho Totais (ATT). As prevalências e intervalos de confiança de 95% (IC95%) de ATT em 2013 e 2019 foram estimadas segundo as variáveis explicativas, Unidades da Federação e capitais. Em 2019, foram calculadas as prevalências e IC95% segundo variáveis explicativas e razões de prevalência (RP) bruta e ajustada por sexo e faixa etária. Resultados: A prevalência de ATT passou de 4,96% (IC95%: 4,55-5,38) em 2013 para 4,13% (IC95%: 3,80-4,46) em 2019. Em 2013, o Pará liderou em prevalência de ATT e em 2019 a maior prevalência foi no Mato Grosso. As prevalências de AT e AD em 2019 foram, respectivamente 2,64% (IC95%: 2,37-2,91) e 1,60% (IC95%: 1,40-1,80). Em 2019, as prevalências para ATT foram mais elevadas para  homens (RP:1,92; IC95% 1,62-2,27); na faixa etária de 18 a 29 anos (RP: 2,71; IC95% 1,99-3,68); pessoas com ensino fundamental completo/médio incompleto (RP: 2,09; IC95% 1,57-2,78); de cor preta (RP: 1,43; IC95% 1,12-1, 84), e menor em pessoas sem carteira de trabalho (RP: 0,77; IC95% 0,66-0,90).  AT foi maior na zona rural (RP: 1,32 (1,09-1,60). Conclusão: Houve redução dos ATT entre 2013 e 2019. Homens, jovens, pretos e indivíduos com menor escolaridade, trabalhadores da zona rural, apresentaram maiores prevalências de AT em 2019, demonstrando uma relação dos processos saúde-doença-acidente.

https://doi.org/10.1590/1980-549720230006.supl.1.1

Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: part II SBCe (SBCe migraine
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Santos, Paulo Sergio Faro

; Melhado, Eliana Meire

; Kaup, Alexandre Ottoni

; Costa, Aline Turbino Neves Martins da

; Roesler, Célia Aparecida de Paula

; Piovesan, Élcio Juliato

; Sarmento, Elder Machado

; Theotonio, Giselle Oliveira Martins

; Campos, Henrique Carneiro de

; Fortini, Ida

; Souza, Jano Alves de

; Maciel Júnior, Jayme Antunes

; Segundo, João Batista Alves

; Carvalho, João José Freitas de

; Speziali, José Geraldo

; Calia, Leandro Cortoni

; Barea, Liselotte Menke

; Queiroz, Luiz Paulo

; Souza, Marcio Nattan Portes

; Figueiredo, Marcos Ravi Cerqueira Ferreira

; Costa, Maria Eduarda Nobre de Magalhães

; Peres, Mário Fernando Prieto

; Jurno, Mauro Eduardo

; Peixoto, Patrícia Machado

; Kowacs, Pedro André

; Rocha Filho, Pedro Augusto Sampaio

; Moreira Filho, Pedro Ferreira

; Silva Neto, Raimundo Pereira

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

Journal Metrics
- Sobre o periódico
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sep 2022, Volume 80 N. 9 Pages 953 - 969

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Migrânea afeta um bilhão de pessoas em todo o mundo e mais de 30 milhões de brasileiros; além disso, é um distúrbio subdiagnosticado e subtratado. Objetivo Sabe-se sobre a necessidade de difundir o conhecimento sobre o tratamento profilático da migrânea; por isso, a Sociedade Brasileira de Cefaleias (SBCe) nomeou um comitê de autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da migrânea episódica com base em artigos da literatura mundial, assim como da experiência pessoal. Métodos As reuniões foram realizadas inteiramente online, com a participação de 12 grupos que revisaram e escreveram sobre as categorias farmacológicas dos medicamentos e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de medicamentos estudadas na parte II deste Consenso foram: anti-hipertensivos, inibidores seletivos de recaptação de serotonina, inibidores de recaptação de serotonina e noradrenalina, bloqueadores dos canais de cálcio, outros medicamentos e politerapia racional. Resultados Desta lista de medicamentos, apenas o candesartan foi estabelecido como eficaz no controle da migrânea episódica. Flunarizina, venlafaxina, duloxetina e pizotifeno foram definidos como provavelmente eficazes, enquanto lisinopril, enalapril, escitalopram, fluvoxamina, quetiapina, atorvastatina, sinvastatina, ciproheptadina e melatonina foram possivelmente eficazes na profilaxia da doença. Conclusões Apesar do esforço da comunidade científica em encontrarmedicamentos realmente eficazes no tratamento da migrânea, dado o grande número de medicamentos testados para este fim, ainda dispomos de poucas opções terapêuticas. 3 brasileiros disso subtratado Sabese Sabe se isso SBCe (SBCe mundial pessoal online 1 final reuniramse reuniram documento antihipertensivos, antihipertensivos anti hipertensivos, hipertensivos anti-hipertensivos noradrenalina cálcio racional Flunarizina venlafaxina lisinopril enalapril escitalopram fluvoxamina quetiapina atorvastatina sinvastatina doença fim terapêuticas

Abstract Background Migraine affects 1 billion people worldwide and > 30 million Brazilians; besides, it is an underdiagnosed and undertreated disorder. Objective The need to disseminate knowledge about the prophylactic treatment of migraine is known, so the Brazilian Headache Society (SBCe, in the Portuguese acronym) appointed a committee of authors with the objective of establishing a consensus with recommendations on the prophylactic treatment of episodic migraine based on articles from the world literature as well as from personal experience. Methods Meetings were held entirely online, with the participation of 12 groups that reviewed and wrote about the pharmacological categories of drugs and, at the end, met to read and finish the document. The drug classes studied in part II of this Consensus were: antihypertensives, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, calcium channel blockers, other drugs, and rational polytherapy. Results From this list of drugs, only candesartan has been established as effective in controlling episodic migraine. Flunarizine, venlafaxine, duloxetine, and pizotifen were defined as likely to be effective, while lisinopril, enalapril, escitalopram, fluvoxamine, quetiapine, atorvastatin, simvastatin, cyproheptadine, and melatonin were possibly effective in prophylaxis of the disease. Conclusions Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options. 3 Brazilians besides disorder known SBCe, SBCe (SBCe acronym experience online end document antihypertensives inhibitors blockers polytherapy Flunarizine venlafaxine duloxetine lisinopril enalapril escitalopram fluvoxamine quetiapine atorvastatin simvastatin cyproheptadine disease purpose options

https://doi.org/10.1055/s-0042-1755320

Consensus of the Brazilian Headache Society (SBCe) for the Prophylactic Treatment of Episodic Migraine: part I SBCe (SBCe Migraine
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Melhado, Eliana Meire

; Santos, Paulo Sergio Faro

; Kaup, Alexandre Ottoni

; Costa, Aline Turbino Neves Martins da

; Roesler, Célia Aparecida de Paula

; Piovesan, Élcio Juliato

; Sarmento, Elder Machado

; Theotonio, Giselle Oliveira Martins

; Campos, Henrique Carneiro de

; Fortini, Ida

; Souza, Jano Alves de

; Maciel Júnior, Jayme Antunes

; Segundo, João Batista Alves

; Carvalho, João José Freitas de

; Speziali, José Geraldo

; Calia, Leandro Cortoni

; Barea, Liselotte Menke

; Queiroz, Luiz Paulo

; Souza, Marcio Nattan Portes

; Figueiredo, Marcos Ravi Cerqueira Ferreira

; Costa, Maria Eduarda Nobre de Magalhães

; Peres, Mário Fernando Prieto

; Jurno, Mauro Eduardo

; Peixoto, Patrícia Machado

; Kowacs, Pedro André

; Rocha-Filho, Pedro Augusto Sampaio

; Moreira Filho, Pedro Ferreira

; Silva-Neto, Raimundo Pereira

; Fragoso, Yara Dadalti

Arquivos de Neuro-Psiquiatria

Journal Metrics
- Sobre o periódico
- SciELO Analytics

aug 2022, Volume 80 N. 8 Pages 845 - 861

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo A Sociedade Brasileira de Cefaleia (SBCe) nomeou um Comitê de Autores com o objetivo de estabelecer um consenso com recomendações sobre o tratamento profilático da enxaqueca episódica com base em artigos da literatura mundial e da experiência pessoal. A enxaqueca é um distúrbio subdiagnosticado e subtratado que acomete um bilhão de pessoas no mundo e mais de 30 milhões de brasileiros. É conhecido na comunidade médica de neurologistas e, sobretudo, dos especialistas em cefaleia, a necessidade de se divulgar o conhecimento sobre o tratamento profilático da enxaqueca. Com esta finalidade, aliada às necessidades de atualizações de drogas e de se aumentar o conhecimento sobre a doença em si (frequência, intensidade, duração, impacto e talvez a progressão da enxaqueca), foi elaborado este Consenso, com metodologia totalmente on-line, por 12 grupos que revisaram e escreveram sobre as categorias farmacológicas das drogas e, ao final, reuniram-se para a leitura e conclusão do documento. As classes de drogas estudadas para este Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais do antipeptídeo relacionado ao gene da calcitonina (peptídeo relacionado ao gene da calcitonina — anti-CGRP), betabloqueadores, anti-hipertensivos, inibidores dos canais de cálcio, outros antidepressivos (inibidores seletivos de recaptação de serotonina, ISRSs, e antidepressivos de ação dual), outras drogas, e politerapia. O tratamento hormonal, bem como anti-inflamatórios e triptanas em esquema de profilaxia mínima (miniprofilaxia), será abordado em um capítulo próprio. As classes de drogas estudadas na parte I do Consenso foram: anticonvulsivantes, antidepressivos tricíclicos, anticorpos monoclonais anti-CGRP, e betabloqueadores. SBCe (SBCe pessoal 3 brasileiros sobretudo cefaleia finalidade frequência, frequência (frequência intensidade duração enxaqueca, , enxaqueca) online, online on line, line on-line 1 final reuniramse reuniram documento foram anticonvulsivantes tricíclicos peptídeo antiCGRP, antiCGRP anti CGRP anti-CGRP) betabloqueadores antihipertensivos, antihipertensivos hipertensivos, hipertensivos anti-hipertensivos cálcio serotonina ISRSs dual, dual dual) politerapia hormonal antiinflamatórios inflamatórios miniprofilaxia, miniprofilaxia (miniprofilaxia) próprio CGRP, anti-CGRP (miniprofilaxia

Abstract The Brazilian Headache Society (Sociedade Brasileira de Cefaleia, SBCe, in Portuguese) nominated a Committee of Authors with the aim of establishing a consensus with recommendations regarding prophylactic treatment for episodic migraine based on articles published in the worldwide literature, as well as personal experience. Migraine affects 1 billion people around the world and more than 30 million Brazilians. In addition, it is an underdiagnosed and undertreated disorder. It is well known within the medical community of neurologists, and especially among headache specialists, that there is a need to disseminate knowledge about prophylactic treatment for migraine. For this purpose, together with the need for drug updates and to expand knowledge of the disease itself (frequency, intensity, duration, impact and perhaps the progression of migraine), this Consensus was developed, following a full online methodology, by 12 groups who reviewed and wrote about the pharmacological categories of the drugs used and, at the end of the process, met to read and establish conclusions for this document. The drug classes studied were: anticonvulsants, tricyclic antidepressants, monoclonal anti-calcitonin gene-related peptide (anti-CGRP) antibodies, beta-blockers, antihypertensives, calcium channel inhibitors, other antidepressants (selective serotonin reuptake inhibitors, SSRIs, and dual-action antidepressants), other drugs, and polytherapy. Hormonal treatment and anti-inflammatories and triptans in minimum prophylaxis schemes (miniprophylaxis) will be covered in a specific chapter. The drug classes studied for part I of the Consensus were: anticonvulsants, tricyclic antidepressants, monoclonal anti-CGRP antibodies, and beta-blockers. Sociedade Cefaleia SBCe Portuguese literature experience 3 Brazilians addition disorder neurologists specialists purpose frequency, frequency (frequency intensity duration migraine, , migraine) developed methodology process document were anticonvulsants anticalcitonin anti calcitonin generelated gene related antiCGRP CGRP (anti-CGRP antibodies betablockers, betablockers beta blockers, blockers beta-blockers antihypertensives inhibitors selective SSRIs dualaction dual action antidepressants) polytherapy antiinflammatories inflammatories miniprophylaxis (miniprophylaxis chapter betablockers. blockers.

https://doi.org/10.1055/s-0042-1756441

Correlations between Web Searches and COVID-19 Epidemiological Indicators in Brazil
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Locatelli, Marcelo Sartori

; Cunha, Evandro L. T. P

; Guiginski, Janaína

; Franco, Ramon A. S

; Bernardes, Tereza

; Alzamora, Pedro Loures

; Silva, Daniel Victor F. da

; Ganem, Marcelo Augusto S

; Santos, Thiago H. M

; Carvalho, Anne I. R

; Souza, Leandro M. V

; Paixão, Gabriela P. F

; Chaves, Elisa França

; Santos, Guilherme Bezerra dos

; Santos, Rafael Vinícius dos

; Freitas, Amanda Cupertino de

; Flores, Matheus G

; Biezuner, Rachel F

; Cardoso, Rodolfo Lins

; Fonseca, Rodrigo Machado

; Silva, Ana Paula Couto da

; Meira Jr, Wagner

Brazilian Archives of Biology and Technology

Journal Metrics
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2022, Volume 65 elocation e22210648

Abstract: En | Text: En | PDF: En

Abstract: COVID-19 rapidly spread across the world in an unprecedented outbreak with a massive number of infected and fatalities. The pandemic was heavily discussed and searched on the internet, which generated big amounts of data related to it. This led to the possibility of attempting to forecast coronavirus indicators using the internet data. For this study, Google Trends statistics for 124 selected search terms related to pandemic were used in an attempt to find which keywords had the best Spearman correlations with a lag, as well as a forecasting model. It was found that keywords related to coronavirus testing among some others, such as “I have contracted covid”, had high correlations (≥0.7) with few weeks of lag (≤4 weeks). Besides that, the ARIMAX model using those keywords had promising results in predicting the increase or decrease of epidemiological indicators, although it was not able to predict their exact values. Thus, we found that Google Trends data may be useful for predicting outbreaks of coronavirus a few weeks before they happen, and may be used as an auxiliary tool in monitoring and forecasting the disease in Brazil.

https://doi.org/10.1590/1678-4324-2022210648

Determination of phenolic and triterpenic compounds in Jatropha gossypiifolia L by Ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS)
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Silveira, Rudinei da Silva

; Leal, Gabriela Camera

; Molin, Thais Ramos Dal

; Faccin, Henrique

; Gobo, Luciana Assis

; Silveira, Géssica Domingos da

; Souza, Mariana Tatsch da Silva

; Lameira, Osmar Alves

; Carvalho, Leandro Machado de

; Viana, Carine

Brazilian Journal of Pharmaceutical Sciences

Journal Metrics
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2020, Volume 56 elocation e17262

Abstract: En | Text: En | PDF: En

This work describes the chemical characterization of extracts of Jatropha gossypiifolia (from Amazonia region) concerning the presence of phenolic and triterpenic compounds using Ultra High Perfomance Liquid chromatography coupled to Mass Spectrometry in Tandem (UHPLC-MS/MS) methods. The studied compounds belong to the most frequently found classes in medicinal plants (triterpenes, flavonoids, flavones, hydroxycinnamic acids, coumarins, catechins and stilbenes), which have been analyzed as chemical and bioactive markers in hydroethanolic and aqueous extracts. Several polyphenolic compounds identified herein are unprecedented in the scientific literature for this species. The chemical markers identified and quantified in the studied extracts of J. gossypiifolia were gallic acid, chlorogenic acid, catechin, caffeic acid, vanillic acid, p-coumaric acid, ferullic acid, rutin, quercitrin, 3-acetylcoumarin, trans-cinnamic acid, quercetin, luteolin, apigenin, kaempferol, chrysin. α-amyrin, β-amyrin and lupeol. As the majority compounds, (+)-catechin, p-coumaric acid, ferulic acid, luteolin, α-amyrin and β-amyrin were found to be present at mg kg-1 levels. J. gossypiifolia extracts presented a high in vitro activity against different reactive oxygen species (hydroxyl, peroxyl, and superoxide anion radicals). Several polyphenolic compound data presented herein are unprecedented in the scientific literature for this plant species. As a result, this plant can be a new source of bioactive molecules for therapeutic purposes.

https://doi.org/10.1590/s2175-97902019000417262 1426 downloads

Characteristics and outcomes of patients with COVID-19 admitted to the ICU in a university hospital in São Paulo, Brazil - study protocol
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Ferreira, Juliana C.

; Ho, Yeh-Li

; Besen, Bruno A.M.P.

; Malbuisson, Luiz M.S.

; Taniguchi, Leandro U.

; Mendes, Pedro V.

; Costa, Eduardo L.V.

; Park, Marcelo

; Daltro-Oliveira, Renato

; Roepke, Roberta M.L.

; Silva Jr, João M.

; Carmona, Maria José C.

; Carvalho, Carlos Roberto Ribeiro

; Hirota, Adriana

; Kanasiro, Alberto Kendy

; Crescenzi, Alessandra

; Fernandes, Amanda Coelho

; Miethke-Morais, Anna

; Bellintani, Arthur Petrillo

; Canasiro, Artur Ribeiro

; Carneiro, Bárbara Vieira

; Zanbon, Beatriz Keiko

; Batista, Bernardo Pinheiro De Senna Nogueira

; Nicolao, Bianca Ruiz

; Besen, Bruno Adler Maccagnan Pinheiro

; Biselli, Bruno

; Macedo, Bruno Rocha De

; Toledo, Caio Machado Gomes De

; Pompilio, Carlos Eduardo

; Carvalho, Carlos Roberto Ribeiro De

; Mol, Caroline Gomes

; Stipanich, Cassio

; Bueno, Caue Gasparotto

; Garzillo, Cibele

; Tanaka, Clarice

; Forte, Daniel Neves

; Joelsons, Daniel

; Robira, Daniele

; Costa, Eduardo Leite Vieira

; Silva Júnior, Elson Mendes Da

; Regalio, Fabiane Aliotti

; Segura, Gabriela Cardoso

; Marcelino, Gustavo Brasil

; Louro, Giulia Sefrin

; Ho, Yeh-Li

; Ferreira, Isabela Argollo

; Gois, Jeison de Oliveira

; Silva Junior, Joao Manoel Da

; Reusing Junior, Jose Otto

; Ribeiro, Julia Fray

; Ferreira, Juliana Carvalho

; Galleti, Karine Vusberg

; Silva, Katia Regina

; Isensee, Larissa Padrao

; Oliveira, Larissa dos Santos

; Taniguchi, Leandro Utino

; Letaif, Leila Suemi

; Lima, Lígia Trombetta

; Park, Lucas Yongsoo

; Chaves Netto, Lucas

; Nobrega, Luciana Cassimiro

; Haddad, Luciana

; Hajjar, Ludhmila

; Malbouisson, Luiz Marcelo

; Pandolfi, Manuela Cristina Adsuara

; Park, Marcelo

; Carmona, Maria José Carvalho

; Andrade, Maria Castilho Prandini H De

; Santos, Mariana Moreira

; Bateloche, Matheus Pereira

; Suiama, Mayra Akimi

; Oliveira, Mayron Faria de

; Sousa, Mayson Laercio

; Louvaes, Michelle

; Huemer, Natassja

; Mendes, Pedro

; Lins, Paulo Ricardo Gessolo

; Santos, Pedro Gaspar Dos

; Moreira, Pedro Ferreira Paiva

; Guazzelli, Renata Mello

; Reis, Renato Batista Dos

; Oliveira, Renato Daltro De

; Roepke, Roberta Muriel Longo

; Pedro, Rodolpho Augusto De Moura

; Kondo, Rodrigo

; Rached, Samia Zahi

; Fonseca, Sergio Roberto Silveira Da

; Borges, Thais Sousa

; Ferreira, Thalissa

; Cobello Junior, Vilson

; Sales, Vivian Vieira Tenório

; Ferreira, Willaby Serafim Cassa

Clinics

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2020, Volume 75 elocation e2294

Abstract: En | Text: En | PDF: En

OBJECTIVES: We designed a cohort study to describe characteristics and outcomes of patients with coronavirus disease (COVID-19) admitted to the intensive care unit (ICU) in the largest public hospital in Sao Paulo, Brazil, as Latin America becomes the epicenter of the pandemic. METHODS: This is the protocol for a study being conducted at an academic hospital in Brazil with 300 adult ICU beds dedicated to COVID-19 patients. We will include adult patients admitted to the ICU with suspected or confirmed COVID-19 during the study period. The main outcome is ICU survival at 28 days. Data will be collected prospectively and retrospectively by trained investigators from the hospital’s electronic medical records, using an electronic data capture tool. We will collect data on demographics, comorbidities, severity of disease, and laboratorial test results at admission. Information on the need for advanced life support and ventilator parameters will be collected during ICU stay. Patients will be followed up for 28 days in the ICU and 60 days in the hospital. We will plot Kaplan-Meier curves to estimate ICU and hospital survival and perform survival analysis using the Cox proportional hazards model to identify the main risk factors for mortality. ClinicalTrials.gov: NCT04378582. RESULTS: We expect to include a large sample of patients with COVID-19 admitted to the ICU and to be able to provide data on admission characteristics, use of advanced life support, ICU survival at 28 days, and hospital survival at 60 days. CONCLUSIONS: This study will provide epidemiological data about critically ill patients with COVID-19 in Brazil, which could inform health policy and resource allocation in low- and middle-income countries.

https://doi.org/10.6061/clinics/2020/e2294 1957 downloads

Regulatory framework for dietary supplements and the public health challenge
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Molin, Thaís Ramos Dal

; Leal, Gabriela Camera

; Müller, Larissa Sabo

; Muratt, Diana Tomazzi

; Marcon, Gabriela Zanella

; Carvalho, Leandro Machado de

; Viana, Carine

Revista de Saúde Pública

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2019, Volume 53 elocation 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

RESUMO OBJETIVO O novo marco regulatório para os suplementos alimentares no Brasil instigou a presente análise do panorama atual desses produtos e os desafios impostos pelas novas diretrizes. MÉTODOS Foi realizado um estudo qualitativo, observacional e descritivo dos suplementos alimentares comercializados em lojas virtuais brasileiras, com o auxílio da ferramenta de busca Google®. Os ingredientes declarados nos rótulos, bem como os efeitos atribuídos a esses produtos e as alegações comerciais utilizadas como forma de promovê-los foram levados em consideração a fim de avaliarmos as mudanças necessárias para o enquadramento legal nas novas diretrizes. Por fim, com o auxílio de base de dados, foram comparados os efeitos declarados pelos fabricantes e atribuídos a determinados ingredientes com as evidências científicas descritas na literatura. RESULTADOS No total, foram adquiridos 44 suplementos alimentares provenientes de lojas virtuais brasileiras (n = 7). Das amostras estudadas, 34,2% não poderiam ser enquadradas na categoria Suplementos Alimentares, conforme preconiza a nova regulação da Agência Nacional de Vigilância Sanitária, em decorrência de presença de substâncias não permitidas; 16% dos produtos deveriam ser comercializados como medicamentos. Quanto aos apelos comerciais, 97,7% apresentavam expressões não permitidas. Inúmeras alegações de efeitos atribuídos a determinados produtos, por não possuírem comprovação científica, foram caracterizadas como fraude contra o consumidor. CONCLUSÕES Dada a extensa gama de suplementos alimentares e pontos de comercialização, as mudanças necessárias representam um grande desafio regulatório e de produção, esforço este que visa a proteger a saúde dos consumidores. Algumas lacunas previamente existentes ao marco regulatório ainda não foram totalmente solucionadas.

ABSTRACT OBJECTIVE The new regulatory framework for dietary supplements in Brazil prompted this analysis of the current outlook of these products and the challenges posed by the new guidelines. METHODS We conducted a qualitative, observational and descriptive study of dietary supplements commercialized in Brazilian online stores with the help of the Google® search tool. We considered the ingredients on the labels, the effects attributed to these products and the commercial claims used as a means of promoting them to assess the necessary changes for the legal framework in the new guidelines. Finally, with the help of a database, we compared the effects declared by the manufacturers and attributed to certain ingredients with the scientific evidence described in literature. RESULTS In total, we purchased 44 dietary supplements from Brazilian online stores (n = 7). Of the samples studied, 34.2% could not be classified in the category Dietary Supplements, as recommended by the new regulation of the Brazilian Health Regulatory Agency due to the presence of prohibited substances; 16% of products should be commercialized as medicines. Regarding the commercial appeals, 97.7% had banned expressions. Numerous claims of effects attributed to certain products were characterized as consumer fraud because they have no scientific evidence. CONCLUSIONS The necessary changes represent a major regulatory and production challenge due to the wide range of dietary supplements and markets, an effort that aims to protect the consumers’ health. Some previous gaps in the regulatory framework were not fully solved.

https://doi.org/10.11606/s1518-8787.2019053001263

10.

Regulatory framework for dietary supplements and the public health challenge
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Molin, Thaís Ramos Dal

; Leal, Gabriela Camera

; Müller, Larissa Sabo

; Muratt, Diana Tomazzi

; Marcon, Gabriela Zanella

; Carvalho, Leandro Machado de

; Viana, Carine

Revista de Saúde Pública

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2019, Volume 53 elocation 90

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

https://doi.org/10.11606/s1518-8787.2019053001263 7429 downloads

11.

Avaliação ambiental de BTEX (benzeno, tolueno, etilbenzeno, xilenos) e biomarcadores de genotoxicidade em trabalhadores de postos de combustíveis
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Amaral, Isabele Campos Costa

; Carvalho, Leandro Vargas Barreto de

; Pimentel, Joyce Neri da Silva

; Pereira, Angélica Cardoso

; Vieira, Jucilene Aparecida

; Castro, Vinicio Soares de

; Borges, Renato Marçullo

; Alves, Sérgio Rabello

; Nogueira, Simone Mitri

; Tabalipa, Marianne de Medeiros

; Otero, Ubirani Barros

; Oliveira, Katia Maria Pinto Guedes de

; Corrêa, Sérgio Machado

; Fonseca, Antônio Sérgio Almeida

; Moreira, Josino Costa

; Peres, Frederico

; Teixeira, Liliane Reis

; Menezes, Marco Antônio Carneiro

; Mattos, Rita de Cássia Oliveira da Costa

; Sarcinelli, Paula de Novaes

; Larentis, Ariane Leites

Revista Brasileira de Saúde Ocupacional

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2017, Volume 42 Suppl. 1 elocation e8s

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Resumo Introdução: trabalhadores de postos de combustíveis estão expostos às diversas substâncias químicas presentes no ambiente de trabalho, destacando-se entre elas o benzeno, devido às suas propriedades carcinogênicas. Objetivo: avaliar os danos genotóxicos relacionados à exposição ocupacional ao BTEX (benzeno, tolueno, etilbenzeno, xilenos) em trabalhadores de cinco postos de combustíveis do município do Rio de Janeiro, RJ. Metodologia: foram analisadas concentrações de BTEX no ar; atividades das enzimas catalase e glutationa S-transferase; e ensaio cometa em amostras de sangue total de 97 trabalhadores. Resultados: as concentrações de BTEX estavam dentro dos valores preconizados pela NR 15, incluindo Anexo 13-A. Entretanto, uma oscilação nos resultados de ensaio cometa foi observada entre os trabalhadores dos diferentes postos de combustíveis, principalmente em trabalhadores de postos com menores concentrações de benzeno. Discussão: esse resultado está de acordo com a literatura científica atual, que indica uma curva dose-resposta supralinear para o benzeno, observando-se em baixas concentrações um aumento não linear do risco de leucemia, provavelmente relacionado à maior metabolização do benzeno e à maior produção de seus metabólitos tóxicos nessas concentrações. Conclusão: os resultados deste estudo sugerem que a exposição ao BTEX, mesmo em baixas concentrações, contribui para o risco genotóxico à saúde humana.

Abstract Introduction: gas station workers are exposed to several chemicals in their workplace, highlighting benzene, due to its carcinogenic properties. Objective: to assess the genotoxic damage related to occupational exposure to BTEX (benzene, toluene, ethylbenzene, xylenes) in workers of five gas stations in Rio de Janeiro, RJ. Methods: analysis of BTEX concentrations in the air were carried out; as well as activities of catalase and glutathione S-transferase; and comet assay in whole blood samples of 97 workers. Results: BTEX levels were within the Brazilian threshold levels recommended by the NR 15, including Annex 13-A. However, an oscillation of the comet assay results was observed among workers of different gas stations, mainly in workers from gas stations with lower concentrations of benzene. Discussion: this result is in accordance with the current international scientific literature that indicates a supralinear exposure-response curve for benzene. In lower concentrations we could observe a high non-linear risk of leukemia, probably due to a greater benzene metabolism and a higher production of its toxic metabolites. Conclusion: the results of this study suggest that exposure to BTEX, even in low concentrations, contributes to genotoxic risk to human health.

https://doi.org/10.1590/2317-6369000124515 15501 downloads

12.

Serum concentrations and renal expressions of IL-1 and TNF-a early after hemorrhage in rats under the effect of glibenclamide
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Marques, Christiane D'Oliveira

; Diego, Luis Antonio dos Santos

; Marcondes-Machado, Jussara

; Amorim, Renée Lauffer

; Carvalho, Lídia Raquel

; Módolo, Norma Sueli Pinheiro

; Braz, Leandro Gobbo

; Castiglia, Yara Marcondes Machado

Acta Cirúrgica Brasileira

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jul 2016, Volume 31 N. 7 Pages 434 - 441

Abstract: En | Text: En | PDF: En

ABSTRACT PURPOSE: To investigate changes in the serum concentration and renal expression of IL-1 and TNF-α cytokines in rats that received sevoflurane and glibenclamide prior to hemorrhage. METHODS: Two groups of sevoflurane-anesthetized Wistar rats (n=10): G1 (control) and G2 (glibenclamide, 1 µg/g i.v.); hemorrhage of 30% blood volume (10% every 10 min), with replacement using Ringer solution, 5 ml/kg/h. Serum concentrations of IL-1 and TNF-α were studied in the first hemorrhage (T1) and 50 min later (T2), renal expression, at T2. RESULTS: In serum, G1 TNF-α (pg/mL) was T1=178.6±33.5, T2=509.2±118.8 (p<0.05); IL-1 (pg/mL) was T1=148.8±31.3, T2=322.6±115.4 (p<0.05); in G2, TNF-α was T1=486.2±83.6, T2=261.8±79.5 (p<0.05); IL-1 was T1=347.0±72.0, T2= 327.3±90.9 (p>0.05). The expression of TNF-α and IL-1 in the glomerular and tubular cells was significantly higher in the G2 group. CONCLUSIONS: Hemorrhage and glibenclamide elevated TNF-α and IL-1 concentrations in serum and kidneys. High levels of TNF-α already present before the hemorrhage in the glibenclamide group may have attenuated the damages found in the kidneys after the ischemia event.

https://doi.org/10.1590/S0102-865020160070000002 1977 downloads

13.

Beef heifers performance in natural grassland under continuous and rotational grazing in the autumn-winter
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Soares, Émerson Mendes

; Quadros, Fernando Luiz Ferreira de

; Carvalho, Régis Maximiliano Roos de

; Oliveira, Leandro Bittencourt de

; Jochims, Felipe

; Dutra, Gabriela Machado

; Fernandes, Augusto Miranda

; Trindade, José Pedro Pereira

; Ilha, Gustavo Freitas

Ciência Rural

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oct 2015, Volume 45 N. 10 Pages 1859 - 1864

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O objetivo foi avaliar o desempenho de novilhas de corte em pastagem natural sob pastoreio contínuo e rotativo no outono-inverno. Os tratamentos foram distribuídos em um delineamento inteiramente casualizado, conduzidos utilizando a massa de forragem acima de oito cm e 50% da massa de lâminas foliares das touceiras. Os animais foram novilhas Brangus com peso médio inicial de 258kg. As variáveis avaliadas foram massa de forragem disponibilizada (MFd), massa de lâminas foliares das touceiras (MLFt) oferta de forragem disponibilizada (OFd), altura do estrato inferior (Hinf), proteína bruta (PB), fibra em detergente neutro (FDN), digestibilidade da matéria orgânica (DISMO), nutrientes digestíveis totais (NDT), ganho médio diário (GMD), escore de condição corporal (CC), escore do trato reprodutivo (ETR) e taxa de lotação (TL). MFd, Hinf, DISMO e NDT foram decrescentes e OFd, PB e FDN semelhantes ao longo do período experimental. O GMD foi positivo apenas no terceiro período, enquanto que CC, ETR e TL decresceram. O manejo da pastagem natural sob pastoreio contínuo ou rotativo, no outono-inverno, utilizando a massa de forragem acima de oito cm e 50% da massa de lâminas foliares das touceiras, não possibilita o desenvolvimento corporal adequado para acasalamento de novilhas de corte aos 24 meses.

The aim of this study was to evaluate the performance of beef heifers in natural grassland under continuous and rotational grazing during the autumn-winter period. The treatments were distributed in a completely randomized design and conducted using the forage mass above eight cm and 50% of the leaf blades mass of tussocks. The animals were Brangus beef heifers with initial body weight of 258kg. The variables evaluated were available forage mass (FMa), leaf blades mass of tussocks (LBMt), real forage allowance (FAr), sward height of the lower stratum (HLS), crude protein (CP), neutral detergent fiber (NDF), organic matter digestibility (OMD), total digestible nutrients (TDN), average daily gain (ADG), body condition score (BCS), reproductive tract score (RTS) and stocking rate (SR). FMa, HLS, OMD and TDN decreased while FAr, CP and NDF were similar during the experimental period. The ADG was positive only at third experimental period while BCS, RTS and SR decreased over time. The natural grassland management under continuous and rotational grazing during the autumn-winter period, using the forage mass above 8cm and 50% of the leaf blades mass of tussocks, does not allow the adequate corporal development for breeding the beef heifers at 24 months old.

https://doi.org/10.1590/0103-8478cr20141529 1632 downloads

14.

Antifungal activity of extracts from Piper aduncum leaves prepared by different solvents and extraction techniques against dermatophytes Trichophyton rubrum and Trichophyton interdigitale
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Santos, Maximillan Leite

; Magalhães, Chaiana Froés

; Rosa, Marcelo Barcellos da

; Santos, Daniel de Assis

; Brasileiro, Beatriz Gonçalves

; Carvalho, Leandro Machado de

; Silva, Marcelo Barreto da

; Zani, Carlos Leomar

; Siqueira, Ezequias Pessoa de

; Peres, Rodrigo Loreto

; Andrade, Anderson Assunção

Brazilian Journal of Microbiology

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dec 2013, Volume 44 N. 4 Pages 1275 - 1278

Abstract: En | Text: En | PDF: En

The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis.

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15.

Parâmetros climáticos e variação de compostos fenólicos em cevada
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Bezerra, Aline Sobreira

; Nörnberg, José Laerte

; Lima, Fernanda Oliveira

; Rosa, Marcelo Barcellos da

; Carvalho, Leandro Machado de

Ciência Rural

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sep 2013, Volume 43 N. 9 Pages 1546 - 1552

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Objetivou-se quantificar os compostos fenólicos em extrato hidroetanólico de grãos das cultivares de cevada ('BRS Lagoa' e 'MN 743') em dois anos consecutivos de cultivo (2005 e 2006), avaliando a influência dos fatores climáticos nesse conteúdo. Os compostos fenólicos totais foram quantificados pelo método de Folin-Ciocalteau e os teores de rutina e ácidos cafeico e ferúlico por CLAE em fase reversa. O conteúdo de compostos fenólicos totais variou de 0,97 a 1,59 mg AG g-1 de cevada e os fatores climáticos durante o período de plantio e colheita influenciaram no conteúdo. Foram identificados e quantificados nessas cultivares rutina, ácido cafeico e ácido ferúlico. A avaliação dos fatores climáticos no conteúdo de compostos fenólicos em cevada é de grande interesse, visando a sua importância nutricional e recomendação de cultivares com conteúdos expressivos de compostos bioativos.

This study aimed to quantify the phenolic compounds in hydroethanolic extract of cultivar seeds ('BRS Lagoa' and 'MN 743') in two consecutive years of cultivation (2005 and 2006) evaluating the influence of climatic factors in such content. The total phenolic compounds were quantified by Folin-Ciocalteau's method and the levels of rutin and caffeic and ferulic acids by HPLC in the reversed-phase. The concentration of total phenolic compounds ranged from 0.97 to 1.59 mg GA g-1 of barley and the climatic factors during the planting and harvesting influenced the barley content. Caffeic, rutin and ferulic acid were identified and quantified in these cultivars. Assessment of climatic factors on the content of phenolic compounds in barley is of great interest aiming for their nutritional importance and recommendations of cultivars with significant content of bioactive compounds.

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