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au:Carvalho, Joaquim F. de

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Risk factors for eating disorders: an umbrella review of published meta-analyses
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Solmi, Marco

; Radua, Joaquim

; Stubbs, Brendon

; Ricca, Valdo

; Moretti, Davide

; Busatta, Daniele

; Carvalho, Andre F.

; Dragioti, Elena

; Favaro, Angela

; Monteleone, Alessio Maria

; Shin, Jae Il

; Fusar-Poli, Paolo

; Castellini, Giovanni

Brazilian Journal of Psychiatry

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jun 2021, Volume 43 N. 3 Pages 314 - 323

Abstract: En | Text: En | PDF: En

Objective: To grade the evidence about risk factors for eating disorders (anorexia nervosa, bulimia nervosa, and binge eating disorder) with an umbrella review approach. Methods: This was a systematic review of observational studies on risk factors for eating disorders published in PubMed/PsycInfo/Embase until December 11th, 2019. We recalculated random-effect meta-analyses, heterogeneity, small-study effect, excess significance bias and 95% prediction intervals, grading significant evidence (p < 0.05) from convincing to weak according to established criteria. Quality was assessed with the Assessment of Multiple Systematic Reviews 2 (AMSTAR-2) tool. Results: Of 2,197 meta-analyses, nine were included, providing evidence on 50 risk factors, 29,272 subjects with eating disorders, and 1,679,385 controls. Although no association was supported by convincing evidence, highly suggestive evidence supported the association between childhood sexual abuse and bulimia nervosa (k = 29, 1,103 cases with eating disorders, 8,496 controls, OR, 2.73, 95%CI 1.96-3.79, p = 2.1 x 10-9, AMSTAR-2 moderate quality) and between appearance-related teasing victimization and any eating disorder (k = 10, 1,341 cases with eating disorders, 3,295 controls, OR 2.91, 95%CI 2.05-4.12, p = 1.8x10-9, AMSTAR-2 moderate quality). Suggestive, weak, or no evidence supported 11, 29, and 8 associations, respectively. Conclusions: The most credible evidence indicates that early traumatic and stressful events are risk factors for eating disorders. Larger collaborative prospective cohort studies are needed to identify risk factors for eating disorders, particularly anorexia nervosa.

https://doi.org/10.1590/1516-4446-2020-1099 1001 downloads

Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital
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Fink, Thais T.

; Marques, Heloisa H.S.

; Gualano, Bruno

; Lindoso, Livia

; Bain, Vera

; Astley, Camilla

; Martins, Fernanda

; Matheus, Denise

; Matsuo, Olivia M.

; Suguita, Priscila

; Trindade, Vitor

; Paula, Camila S.Y.

; Farhat, Sylvia C.L.

; Palmeira, Patricia

; Leal, Gabriela N.

; Suzuki, Lisa

; Odone Filho, Vicente

; Carneiro-Sampaio, Magda

; Duarte, Alberto José S.

; Antonangelo, Leila

; Batisttella, Linamara R.

; Polanczyk, Guilherme V.

; Pereira, Rosa Maria R.

; Carvalho, Carlos Roberto R.

; Buchpiguel, Carlos A.

; Latronico, Ana Claudia

; Seelaender, Marilia

; Silva, Clovis Artur

; Pereira, Maria Fernanda B.

; Sallum, Adriana M. E.

; Brentani, Alexandra V. M.

; Neto, Álvaro José S.

; Ihara, Amanda

; Santos, Andrea R.

; Canton, Ana Pinheiro M.

; Watanabe, Andreia

; Santos, Angélica C. dos

; Pastorino, Antonio C.

; Franco, Bernadette D. G. M.

; Caruzo, Bruna

; Ceneviva, Carina

; Martins, Carolina C. M. F.

; Prado, Danilo

; Abellan, Deipara M.

; Benatti, Fabiana B.

; Smaria, Fabiana

; Gonçalves, Fernanda T.

; Penteado, Fernando D.

; Castro, Gabriela S. F. de

; Gonçalves, Guilherme S.

; Roschel, Hamilton

; Disi, Ilana R.

; Marques, Isabela G.

; Castro, Inar A.

; Buscatti, Izabel M.

; Faiad, Jaline Z.

; Fiamoncini, Jarlei

; Rodrigues, Joaquim C.

; Carneiro, Jorge D. A.

; Paz, Jose A.

; Ferreira, Juliana C.

; Ferreira, Juliana C. O.

; Silva, Katia R.

; Bastos, Karina L. M.

; Kozu, Katia

; Cristofani, Lilian M.

; Souza, Lucas V. B.

; Campos, Lucia M. A.

; Silva Filho, Luiz Vicente R. F.

; Sapienza, Marcelo T.

; Lima, Marcos S.

; Garanito, Marlene P.

; Santos, Márcia F. A.

; Dorna, Mayra B.

; Aikawa, Nadia E.

; Litvinov, Nadia

; Sakita, Neusa K.

; Gaiolla, Paula V. V.

; Pasqualucci, Paula

; Toma, Ricardo K.

; Correa-Silva, Simone

; Sieczkowska, Sofia M.

; Imamura, Marta

; Forsait, Silvana

; Santos, Vera A.

; Zheng, Yingying

Clinics

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2021, Volume 76 elocation e3511

Abstract: En | Text: En | PDF: En

OBJECTIVES: To prospectively evaluate demographic, anthropometric and health-related quality of life (HRQoL) in pediatric patients with laboratory-confirmed coronavirus disease 2019 (COVID-19) METHODS: This was a longitudinal observational study of surviving pediatric post-COVID-19 patients (n=53) and pediatric subjects without laboratory-confirmed COVID-19 included as controls (n=52) was performed. RESULTS: The median duration between COVID-19 diagnosis (n=53) and follow-up was 4.4 months (0.8-10.7). Twenty-three of 53 (43%) patients reported at least one persistent symptom at the longitudinal follow-up visit and 12/53 (23%) had long COVID-19, with at least one symptom lasting for >12 weeks. The most frequently reported symptoms at the longitudinal follow-up visit were headache (19%), severe recurrent headache (9%), tiredness (9%), dyspnea (8%), and concentration difficulty (4%). At the longitudinal follow-up visit, the frequencies of anemia (11% versus 0%, p=0.030), lymphopenia (42% versus 18%, p=0.020), C-reactive protein level of >30 mg/L (35% versus 0%, p=0.0001), and D-dimer level of >1000 ng/mL (43% versus 6%, p=0.0004) significantly reduced compared with baseline values. Chest X-ray abnormalities (11% versus 2%, p=0.178) and cardiac alterations on echocardiogram (33% versus 22%, p=0.462) were similar at both visits. Comparison of characteristic data between patients with COVID-19 at the longitudinal follow-up visit and controls showed similar age (p=0.962), proportion of male sex (p=0.907), ethnicity (p=0.566), family minimum monthly wage (p=0.664), body mass index (p=0.601), and pediatric pre-existing chronic conditions (p=1.000). The Pediatric Quality of Live Inventory 4.0 scores, median physical score (69 [0-100] versus 81 [34-100], p=0.012), and school score (60 [15-100] versus 70 [15-95], p=0.028) were significantly lower in pediatric patients with COVID-19 at the longitudinal follow-up visit than in controls. CONCLUSIONS: Pediatric patients with COVID-19 showed a longitudinal impact on HRQoL parameters, particularly in physical/school domains, reinforcing the need for a prospective multidisciplinary approach for these patients. These data highlight the importance of closer monitoring of children and adolescents by the clinical team after COVID-19.

https://doi.org/10.6061/clinics/2021/e3511

BRS FP403: high-yielding black-seeded common bean cultivar with superior grain quality and moderate resistance to fusarium wilt
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Souza, Thiago Lívio Pessoa Oliveira de

; Pereira, Helton Santos

; Peloso, Maria José Del

; Faria, Luís Cláudio de

; Costa, Joaquim Geraldo Cáprio da

; Wendland, Adriane

; Díaz, José Luis Cabrera

; Magaldi, Mariana Cruzick de Souza

; Aguiar, Marcelo Sfeir

; Carvalho, Hélio Wilson Lemos de

; Souza Filho, Benedito Fernandes de

; Melo, Carlos Lásaro Pereira de

; Costa, Antônio Félix da

; Almeida, Válter Martins de

; Posse, Sheila Cristina Prucoli

; Melo, Leonardo Cunha

Crop Breeding and Applied Biotechnology

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jul 2019, Volume 19 N. 2 Pages 240 - 244

Abstract: En | Text: En | PDF: En

Abstract BRS FP403 is a common bean cultivar from the black bean market class with high grain yield and yield potential, high commercial and cooking quality, and moderate resistance to fusarium wilt (Fusarium oxysporum f. sp. phaseoli) and root rot diseases (Fusarium solani f. sp. phaseoli and Rhizoctonia solani).

https://doi.org/10.1590/1984-70332019v19n2c34 672 downloads

Immunomodulatory and toxicological evaluation of the fruit seeds from Platonia insignis, a native species from Brazilian Amazon Rainforest
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Lustosa, Ana Karina M.F.

; Arcanjo, Daniel D.R.

; Ribeiro, Rayra G.

; Rodrigues, Klinger Antonio F.

; Passos, Flávia Franceli B.

; Piauilino, Celyane A.

; Silva-Filho, José Couras

; Araújo, Bruno Q.

; Lima-Neto, José S.

; Costa-Júnior, Joaquim S.

; Carvalho, Fernando Aécio A.

; Citó, Antônia Maria das Graças L.

Revista Brasileira de Farmacognosia

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feb 2016, Volume 26 N. 1 Pages 77 - 82

Abstract: En | Text: En | PDF: En

Abstract The “bacuri” (Platonia insignis Mart., Clusiaceae) is a native tropical fruit from the Brazilian Amazon and Northeast Regions. Its seeds are used to treat inflammatory diseases, diarrhea and skin problems in traditional medical practices. Regarding its widespread medicinal uses, it is important to evaluate the biological and toxicological potential of this species. This way, the aim of this study was to investigate the in vitro cytotoxic and immunomodulatory effects of the hexanic extract of P. insignis seeds, as well as its in vivo acute oral toxicity. The biological evaluation was performed by the determination of cytotoxic (MTT and hemolysis assay) and immunomodulatory (phagocytic capacity, lysosomal volume and nitrite production) activities of EHSB in murine peritoneal macrophages. In addition, the oral acute toxicity was evaluated using female Wistar rats treated with EHSB (2.0 g/kg), in accordance with the OECD 423 Guideline. The EHSB showed low toxicity for macrophages in the MTT test (CC50 value: 90.03 µg/ml), as well as for erythrocytes, which caused only 2.5% hemolysis at the highest concentration. A strong immunomodulatory activity was observed by a markedly increase of the NO production, phagocytic ability and lysosomal volume. On the other hand, it was not observed deaths or changes in the clinical and behavioral parameters in the toxicological evaluation. This manner, the present study contributes to the knowledge about the immunomodulatory and toxicological properties of the P. insignis. This may provide perspectives for the evaluation and development of effective and safe phytomedicines created from the Brazilian local biodiversity.

https://doi.org/10.1016/j.bjp.2015.05.014 1430 downloads

Um sistema interligado hidroeólico para o Brasil
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Carvalho, Joaquim F. de

; Sauer, Ildo L.

Estudos Avançados

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2013, Volume 27 N. 77 Pages 117 - 124

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Discute-se neste artigo a possibilidade que se abre ao Brasil, de - graças a seus imensos potenciais hídrico e eólico - produzir, de forma renovável e sustentável, toda a energia elétrica que consome atualmente e consumirá a partir de 2050, quando, segundo o IBGE, a população estará estabilizada em 215 milhões de habitantes.

This paper deals with the possibility that Brazil has - thanks to its immense hydroelectric and wind potentials - to produce in a sustainable way all the electrical energy it consumes nowadays and will consume from 2050 on, when, according to the IBGE, the population will be stabilized at 215 million people.

5395 downloads

Tumor estromal gástrico cístico C-kit negativo
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Barchi, Leandro C.

; Gama-Rodrigues, Joaquim

; Carvalho, Fábio Apm

; Barchi, Marcelo C.

; Oliveira, Olivia C. Grimaldi

; Carneiro, Marcelo F.

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

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dec 2012, Volume 25 N. 4 Pages 300 - 302

Abstract: Pt | Text: Pt | PDF: Pt

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Manejo de irrigação para o feijão-de-metro, nas fases vegetativa e produtiva, em ambiente protegido
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Silva, Wellington G. da

; Carvalho, Jacinto de A.

; Oliveira, Eduardo C.

; Rezende, Fátima C.

; Lima Junior, Joaquim A. de

; Rios, Gervásio F. A.

Revista Brasileira de Engenharia Agrícola e Ambiental

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sep 2012, Volume 16 N. 9 Pages 978 - 984

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

O manejo adequado da irrigação é uma prática agrícola que requer informações para cada cultura explorada, em particular nas fases fenológicas do ciclo produtivo pois muitas espécies possuem períodos críticos durante os quais o estresse hídrico causa sérias reduções na produção. Este trabalho teve, como objetivo, avaliar o efeito de cinco níveis de potencial matricial de água no solo sobre o crescimento e produção do feijão-de-metro. O experimento foi conduzido em casa de vegetação, na área experimental pertencente ao Departamento de Engenharia da Universidade Federal de Lavras, Lavras, MG. O delineamento experimental foi o de blocos casualizados, em esquema fatorial 5 x 2, com quatro repetições. Os tratamentos foram constituídos de cinco potenciais matriciais de água no solo como indicativos do momento de irrigar (-15, -35, -55, -75 e -95 kPa), em duas fases fenológicas (vegetativa e produtiva), monitorados por sensores instalados a 0,15 m de profundidade. Os resultados permitiram concluir que a fase mais sensível ao déficit hídrico foi a produtiva e que a irrigação realizada no potencial matricial em torno de -15 kPa induziu a melhor resposta da cultura quanto ao desenvolvimento, produção e qualidade das vagens.

Proper irrigation water management requires knowledge on each exploited crop; particularly regarding vegetative and productive phases since many species have critical periods during which water stress causes serious yield reductions. This study was undertaken so as to assess the effect of five matric potential levels on asparagus bean growth and yield. The experiment was conducted under greenhouse conditions at the experimental area of Department of Engineering, Federal University of Lavras, Lavras, MG. The experimental design was randomized blocks in factorial 5 x 2. The treatments consisted of five matric potentials as indicative of the irrigation scheduling -15 -35 -55 -75 -95 kPa and at two phenological stages (vegetative and reproductive) as monitored by sensors installed at 0.15 m depth. The results allowed to conclude that the most sensitive phase to water deficit was the productive, and that irrigation held at matric potential around -15 kPa led to better crop response in the development, production and quality of pods.

2880 downloads

Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys
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Motta, Lucimar B.

; Furlan, Cláudia M.

; Santos, Deborah Y. A. C.

; Salatino, Maria L. F.

; Duarte-Almeida, Joaquim M.

; Negri, Giuseppina

; Carvalho, João E. de

; Ruiz, Ana Lúcia T. G.

; Cordeiro, Inês

; Salatino, Antonio

Revista Brasileira de Farmacognosia

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dec 2011, Volume 21 N. 6 Pages 972 - 977

Abstract: En | Text: En | PDF: En

Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.

3903 downloads

Larvicidal activity of the water extract of Moringa oleifera seeds against Aedes aegypti and its toxicity upon laboratory animals
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Ferreira, Paulo M.P.

; Carvalho, Ana F.U.

; Farias, Davi F.

; Cariolano, Nara G.

; Melo, Vânia M.M.

; Queiroz, Maria G.R.

; Martins, Alice M.C.

; Machado-Neto, Joaquim G.

Anais da Academia Brasileira de Ciências

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jun 2009, Volume 81 N. 2 Pages 207 - 216

Abstract: Pt En | Text: Pt En | PDF: Pt | PDF: En

Neste trabalho, o extrato aquoso das sementes de Moringaoleifera (EASMO) foi avaliado quanto aos seus efeitos biológicos sobre ovos e larvas de Aedes aegypti no 3ºestágio de desenvolvimento e sua toxicidade sobre animais de laboratório(Daphnia magna, camundongos e ratos). O EASMO bruto revelou uma CL50 de 1.260 µg/mL, causando 99, 2 ± 2, 9% de mortalidade em 24 h na concentração de 5.200 µg/mL, embora o mesmo não tenha sido capaz de impedir a eclosão dos ovos. A atividade larvicida extinguiu-se após aquecimento do extrato a 80ºC/10 min. Diálises sucessivas do EASMO bruto resultaram em duas frações solúveis em água (Fração dializável, FD; Fração nãodializável, FND), dentre as quais apenas a FD mostrou ação larvicida. Testes de toxicidade aguda realizadosem dáfnias (CE50 de 188, 7 µg/mL) e camundongos (DL50 de446,5 mg/kg de peso corpóreo) evidenciaram baixa toxicidade. Apesar da hipertrofia tímica, o EASMO mostrou ser atóxicoapós tratamento subagudo via oral em ratos. Conclui-se, portanto, que o EASMO apresenta substâncias com capacida de larvicida contra Ae. aegypti, as quais possuem massa molecular aparente menor que 12 kDa e potencial tóxico moderado.

In this work, biological effects of the water extract of Moringa oleifera seeds (WEMOS) were assessed on eggs and 3rd instar larvae of Aedes aegypti and on its toxicity upon laboratory animals (Daphnia magna, mice and rats). Crude WEMOS showed a LC50 value of 1260µg/mL, causing 99.2 ± 2.9% larvae mortality within 24 h at 5200µg/mL, though this larvicidal activity has been lost completely at 80ºC/10 min. WEMOS did not demonstrate capacity to prevent egg hatching. After extensive dialyses of the crude WEMOS into watersoluble dialyzable (DF) and nondyalizable (NDF) fractions, only DF maintained its efficacy to kill larvae. Acute toxicity evaluations on daphnids (EC50 of 188.7µg/mL) and mice (LD50 of 446.5 mg/kg body weight) pointed out to low toxicity. Despite the thymus hypertrophy, WEMOS revealed to be harmless in orally and subacutelytreated rats. In conclusion, WEMOS has thermostable bioactive compounds against Ae. aegypti larvae with apparent molecular mass lower than 12 kDa and moderately toxic potential.

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Cutinase structure, function and biocatalytic applications
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Carvalho, Cristina M. L.

; Aires-Barros, Maria Raquel

; Cabral, Joaquim M. S.

Electronic Journal of Biotechnology

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dec 1998, Volume 1 N. 3 Pages 28 - 29

Abstract: En | Text: En | PDF: En

This review analyses the role of cutinases in nature and their potential biotechnological applications. The cloning and expression of a fungal cutinase from Fusarium solani f. pisi, in Escherichia coli and Saccharomyces cerevisiae hosts are described. The three dimensional structure of this cutinase is also analysed and its function as a lipase discussed and compared with other lipases. The biocatalytic applications of cutinase are described taking into account the preparation of different cutinase forms and the media where the different types of enzymatic reactions have been performed, namely hydrolysis, esterification, transesterification and resolution of racemic mixtures. The stability of cutinase preparations is discussed, particularly in anionic reversed micelles considering the role of hexanol as substrate, co-surfactant and stabilizer. Process development based on the operation of cutinase reactors is also reviewed.

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